smi35A_Dmel MLDRCEMPIQL---------------------------DN---EK---------------
Dyrk3_Dmel MINQNLTHTGIA-------------Q----N-------NT--------------------
DYRK4_Mmus MQLLRLPALTRT-------------E--TSM-------DT---NK----AR---------
DYRK3_Mmus MGGAARDRGRKD-------------A-A--L-------PG---A-----GL---------
DYRK2_Mmus MLTRKPSAAAPA-------------A----Y-------PT---GR----GG---------
mbk-2_Cele MAALASFTRNSR-------------S-YGQQ-------PIDVTQQ----GQ---------
C36B7.2_Cele MADIQRHFSNLV-------------I------------GA----S----P----------
C36B7.1_Cele MSLLIKSVQIVK-------------L------------HA----F---------------
DYRK4_Hsap MQLLPPPIRTGT-------------K--TQM-------DA---KK----PR---------
DYRK3_Hsap MGGTARGPGRKD-------------A-G--P-------PG---A-----GL---------
DYRK2_Hsap MLTRKPSAAAPA-------------A----Y-------PT---GR----GG---------
Dyrk2_Ddis MTSLHKQIIESH-------------NND--I-------TK----------L---------
5306_Tthe MYIFNTFIQFCSQTKEAEKVQSTRNS----F-------AI---DQKNKDSI---------
5356_Tthe MQFYNPNSSSSA-------------S----K-------NS---NI----KV---------
5655_Tthe MHNNSSANN----------------S----F-------NN---EQ----AL---------
DYRK2_Spur MVDSMVDAIAR-------------------K-------PN---LQ----AS---------
DYRK4_Spur MPACLHGVASMG-------------K------------------R----P----------
CC1G_13957_Ccin MSASPDPPQQYK-------------A----------------------------------
AqueK112_Aque MERGTGSTKERS-------------F--SYS-------KA----T----PL---------
AqueK113_Aque MLAMYNSQSLTS-------------A------------NT--------------------
DYRK2_b_Smoe MAQTDRSAYADV-------------A----------------------------------
DYRK2_a_Smoe MAQTDRSAYADV-------------A----------------------------------
GK034_Glam MFAPGNSARAQR-------------Q-V--I-------PG---DHF---GL---------
GK033_Glam MDTITLIAGFLR-------------Q-HGENELAENVENC---ES----LR---------
GK032_Glam MIQPEALHQLIY----------------DHV-------YV---KY----GHQLAFTIRAL
*
smi35A_Dmel -----------------------------------------LRR----------------
Dyrk3_Dmel -E------------------------K--------------ANR----------------
DYRK4_Mmus ------------------------------------------KR----------------
DYRK3_Mmus -P------------------------P--------------QQR----------------
DYRK2_Mmus -D------------------------T--------------AVR----------------
mbk-2_Cele RD-RSVMSLD----------------A--------------QGR----------------
C36B7.2_Cele ------------------------------------------LT----------------
C36B7.1_Cele ------------------------------------------------------------
DYRK4_Hsap ------------------------------------------KC----------------
DYRK3_Hsap -P------------------------P--------------QQR----------------
DYRK2_Hsap -D------------------------S--------------AVR----------------
Dyrk2_Ddis -K--SSMSTR----------------AA-------------ARRSVCLSSMSYTLG----
5306_Tthe -L-Q----SN--------------------------------------------------
5356_Tthe -Q-QN-------------------------------------------------------
5655_Tthe -L-ST---VD--------------------------------------------------
DYRK2_Spur -----------------------------------------RTR----------------
DYRK4_Spur ------------------------------------------------------------
CC1G_13957_Ccin ---------R----------------PA-------------ALAIHDDEGTQPSDGDDQI
AqueK112_Aque -L------------------------PSLTSPRGSENGGSHFDR----------------
AqueK113_Aque -K------------------------T--------------FNR----------------
DYRK2_b_Smoe ------------------------------------------------------------
DYRK2_a_Smoe ------------------------------------------------------------
GK034_Glam -V--I-TSG-----------------------------------------RSVSKG----
GK033_Glam -RETRI-TTDLEFLLNISRGCVTVETL--------------ANR----------------
GK032_Glam LN------------------------A--------------KER----------------
smi35A_Dmel ---------D------------------------------------------V-------
Dyrk3_Dmel ---------H------------------------------------------Q-------
DYRK4_Mmus ---------S------------------------------------------L-------
DYRK3_Mmus ---------R------------------------------------------L-------
DYRK2_Mmus ---------Q------------------------------------------L-------
mbk-2_Cele ---------S-------VSHECPTSTTLVR---------------------QL-------
C36B7.2_Cele ---------K------------------------------------------L-------
C36B7.1_Cele ------------------------------------------------------------
DYRK4_Hsap ---------D------------------------------------------L-------
DYRK3_Hsap ---------R------------------------------------------L-------
DYRK2_Hsap ---------Q------------------------------------------L-------
Dyrk2_Ddis --------AD------------------------------------------D-------
5306_Tthe -----------------IS---------QPESTKNHFGYQNQLAHQQIQQQQL----QQQ
5356_Tthe -----------------L------------------------------------------
5655_Tthe -----------------LA---------SQ---------------------DI----SA-
DYRK2_Spur ---------S------------------------------------------L-------
DYRK4_Spur ------------------------------------------------------------
CC1G_13957_Ccin DNCQHQHLL---------------------------------------------------
AqueK112_Aque ---------S------------------------------------------FMRKGI--
AqueK113_Aque ---------T------------------------------------------L-------
DYRK2_b_Smoe ------------------------------------------------------------
DYRK2_a_Smoe ------------------------------------------------------------
GK034_Glam --------RD------------------------------------------Q-------
GK033_Glam ---------SAMIKEHNM------------------------------------------
GK032_Glam ---------C------------------------------------------M-------
smi35A_Dmel ------------------------------------------------------------
Dyrk3_Dmel ------------------Y----R------------------------------------
DYRK4_Mmus ------------------T----T--------------------------FP-ILKARKK
DYRK3_Mmus ------------------G-----------------------------------------
DYRK2_Mmus ------------------Q----A------------------------------------
mbk-2_Cele ------------------Y----L------------------------------------
C36B7.2_Cele ------------------W----A------------------------------------
C36B7.1_Cele ------------------------------------------------------------
DYRK4_Hsap ------------------T----P--------------------------FL-VLKARKK
DYRK3_Hsap ------------------G-----------------------------------------
DYRK2_Hsap ------------------Q----A------------------------------------
Dyrk2_Ddis ------------------V----TPITSNTTPSNNNNNNNTTTTITTTTTTP-TISPL-K
5306_Tthe QQSLQQMQQQQQQMTLQQS-----------------------------------------
5356_Tthe ------------------N-----------------------------------------
5655_Tthe ------------------Q-----------------------------------------
DYRK2_Spur ------------------T----Q------------------------------------
DYRK4_Spur ---------------------------------------------------------REK
CC1G_13957_Ccin -----------------------QPLTINVSHQDNDDSNHSRSTSVTSSLDP-YYFGL-A
AqueK112_Aque ------------------S----S--------------------------LSLSERESKK
AqueK113_Aque ------------------V----Y------------------------------------
DYRK2_b_Smoe ------------------------------------------------------------
DYRK2_a_Smoe ------------------------------------------------------------
GK034_Glam ------------------A----S------------------------------------
GK033_Glam ------------------ASTIDK-----------------------FVIHP-VFFGR-R
GK032_Glam ------------------SKLVAS------------------------------------
smi35A_Dmel -R------------------------------------------------LS--------
Dyrk3_Dmel -----------------------------------------------------D------
DYRK4_Mmus QS------------------------------------------------FT-S------
DYRK3_Mmus ------------------------------------------------------------
DYRK2_Mmus -----------------------------------------------------S------
mbk-2_Cele --------------------------------------------------PQ-I------
C36B7.2_Cele -----------------------------------------------------D------
C36B7.1_Cele ------------------------------------------------------------
DYRK4_Hsap QK------------------------------------------------FT-S------
DYRK3_Hsap ------------------------------------------------------------
DYRK2_Hsap -----------------------------------------------------S------
Dyrk2_Ddis QS------------------------------------------------TT-G------
5306_Tthe -----------------------------------------------------Q------
5356_Tthe -----------------------------------------------------N------
5655_Tthe -----------------------------------------------------N------
DYRK2_Spur --------------------------------------------------G--D------
DYRK4_Spur NH------------------------------------------------IS-N------
CC1G_13957_Ccin ES------------------------------------------------PE-H------
AqueK112_Aque SH------------------------------------------------FT-H------
AqueK113_Aque --------------------------------------------------P--S------
DYRK2_b_Smoe ------------------------------------------------------------
DYRK2_a_Smoe ------------------------------------------------------------
GK034_Glam -----------------------------------------------------D------
GK033_Glam RALENEFLLEMFRDIDTKVDYLGLVPVTSKRYRMSVCHKQPYQHLYLKRIFPADQKLKGL
GK032_Glam -----------------------------------------------------ES-----
smi35A_Dmel ------------------------------------------------------------
Dyrk3_Dmel ---S--------------------------------------------------------
DYRK4_Mmus -VKV--------------------------------------------------------
DYRK3_Mmus ------------------------------------------------------------
DYRK2_Mmus ---P--------------------------------------------------------
mbk-2_Cele ---P--------------------------------------------------------
C36B7.2_Cele ---H--------------------------------------------------------
C36B7.1_Cele ---F--------------------------------------------------------
DYRK4_Hsap -AKV--------------------------------------------------------
DYRK3_Hsap ------------------------------------------------------------
DYRK2_Hsap ---P--------------------------------------------------------
Dyrk2_Ddis ---S--------------------------------------------------------
5306_Tthe ---N--------------------------------------------------------
5356_Tthe ---S--------------------------------------------------------
5655_Tthe ---S--------------------------------------------------------
DYRK2_Spur ---T--------------------------------------------------------
DYRK4_Spur ---G--------------------------------------------------------
CC1G_13957_Ccin ---NPNQLSITPDHPPPNEPVTPARNPASIDRRGLVGVGELATPRWTRDPSPDPHLDDDV
AqueK112_Aque -SLG--------------------------------------------------------
AqueK113_Aque ---S--------------------------------------------------------
DYRK2_b_Smoe ------------------------------------------------------------
DYRK2_a_Smoe ------------------------------------------------------------
GK034_Glam ---A--------------------------------------------------------
GK033_Glam APD---------------------------------------------------------
GK032_Glam ------------------------------------------------------------
smi35A_Dmel ------------------------------------------------------------
Dyrk3_Dmel ----------------------------------------------------G----L--
DYRK4_Mmus ----------------------------------------------------ESKPLGH-
DYRK3_Mmus ------------------------------------------------------------
DYRK2_Mmus ----------------------------------------------------G----I--
mbk-2_Cele ----------------------------------------------------Q----SA-
C36B7.2_Cele ----------------------------------------------------G----T--
C36B7.1_Cele ----------------------------------------------------Q----L--
DYRK4_Hsap ----------------------------------------------------GSKLSVQ-
DYRK3_Hsap ------------------------------------------------------------
DYRK2_Hsap ----------------------------------------------------G----L--
Dyrk2_Ddis ----------------------------------------------------I-------
5306_Tthe ----------------------------------------------------Q----LNQ
5356_Tthe ----------------------------------------------------Q----L--
5655_Tthe ----------------------------------------------------R----F--
DYRK2_Spur ----------------------------------------------------A----T--
DYRK4_Spur ----------------------------------------------------A----VK-
CC1G_13957_Ccin PPLPDRPEDDAPDSPWTIEAIDGELSDSDEVSAPAPFPASNNVLIFLKVKIPE-------
AqueK112_Aque ----------------------------------------------------G----VH-
AqueK113_Aque ----------------------------------------------------E----V--
DYRK2_b_Smoe ------------------------------------------------------------
DYRK2_a_Smoe ------------------------------------------------------------
GK034_Glam ----------------------------------------------------P-------
GK033_Glam ------------------------------------------------------------
GK032_Glam ------------------------------------------------------------
smi35A_Dmel ------------------------------------------------------------
Dyrk3_Dmel ------------------------------------------------------------
DYRK4_Mmus ------------------------------------------------------------
DYRK3_Mmus ------------------------------------------------------------
DYRK2_Mmus ------------------------------------------------------------
mbk-2_Cele -----------------SFAAAPTS-----------------------------FS----
C36B7.2_Cele ------------------------------------------------------------
C36B7.1_Cele ------------------------------------------------------------
DYRK4_Hsap ------------------------------------------------------------
DYRK3_Hsap ------------------------------------------------------------
DYRK2_Hsap ------------------------------------------------------------
Dyrk2_Ddis ---------------------IPKS-----------------------------IL----
5306_Tthe QHQQQLIMMIQQQQQQQHGQQLPNQ-----------------------------------
5356_Tthe -----------------NNALSPKK-----------------------------NISLDL
5655_Tthe -----------------SSGPSPKS-----------------------------KNFVPI
DYRK2_Spur ------------------------------------------------------------
DYRK4_Spur ------------------------------------------------------------
CC1G_13957_Ccin ---------------------LPPP-----------------------------ARPL--
AqueK112_Aque ------------------------------------------------------------
AqueK113_Aque ------------------------------------------------------------
DYRK2_b_Smoe ---------------------IPQT-----------------------------V-----
DYRK2_a_Smoe ---------------------IPQT-----------------------------V-----
GK034_Glam ---------------------PPPP-----------------------------AR----
GK033_Glam ---------------------SPPAMGYARLSNPYMDYYKGETGFARQIILGHKI-----
GK032_Glam ---------------------EPSAL----------------------------E-----
smi35A_Dmel ------------------------------------------------------------
Dyrk3_Dmel ------------------------------------------------------------
DYRK4_Mmus ------------------------------------------------------------
DYRK3_Mmus ------------------------------------------------------------
DYRK2_Mmus ------------------------------------------------------------
mbk-2_Cele GASSSSSNHH-----------------------HP--V----------------------
C36B7.2_Cele ------------------------------------------------------------
C36B7.1_Cele ------------------------------------------------------------
DYRK4_Hsap ------------------------------------------------------------
DYRK3_Hsap ------------------------------------------------------------
DYRK2_Hsap ------------------------------------------------------------
Dyrk2_Ddis -------------------------------------------------VT---------
5306_Tthe ----------------TSSKKSNQQ-----QQMQQNQI----------------------
5356_Tthe GS-RKI----------------SPLDNSLRKR---IEY----------------------
5655_Tthe TA-KNASNQQAIVMNAIKSKIQNIFQQQQQQRQQPQQL----------------------
DYRK2_Spur ------------------------------------------------------------
DYRK4_Spur ------------------------------------------------------------
CC1G_13957_Ccin -----------------------------RT-----RPSIADESGGEEILYPRNVIQSVP
AqueK112_Aque ------------------------------------------------------------
AqueK113_Aque ------------------------------------------------------------
DYRK2_b_Smoe ------------------------------------------------------------
DYRK2_a_Smoe ------------------------------------------------------------
GK034_Glam ------------------------------------------------------------
GK033_Glam ------------------------------------------------------------
GK032_Glam ------------------------------------------------------------
smi35A_Dmel ------------------------------------------------------------
Dyrk3_Dmel ------------------------------------------------------------
DYRK4_Mmus ------------------------------------------------------------
DYRK3_Mmus ------------------------------------------------------------
DYRK2_Mmus ------------------------------------------------------------
mbk-2_Cele ------------------------------------------------------------
C36B7.2_Cele ------------------------------------------------------------
C36B7.1_Cele ------------------------------------------------------------
DYRK4_Hsap ------------------------------------------------------------
DYRK3_Hsap ------------------------------------------------------------
DYRK2_Hsap ------------------------------------------------------------
Dyrk2_Ddis -------------------KSGSKEEPIV-------------------------------
5306_Tthe ------------------------------------------------------------
5356_Tthe ------------------------------------------------------------
5655_Tthe ------------------------------------------------------------
DYRK2_Spur ------------------------------------------------------------
DYRK4_Spur ------------------------------------------------------------
CC1G_13957_Ccin DHPPPTVVPPLDDHIPKQPRTPASADPPISSPPSAFSSSTRKARKRTSDEFELDQTGALV
AqueK112_Aque ------------------------------------------------------------
AqueK113_Aque ------------------------------------------------------------
DYRK2_b_Smoe ------------------------------------------------------------
DYRK2_a_Smoe ------------------------------------------------------------
GK034_Glam --------------------SAAVAR----------------------------------
GK033_Glam ------------------------------------------------------------
GK032_Glam ------------------------------------------------------------
smi35A_Dmel ------------------------------------------------------------
Dyrk3_Dmel ------------------------------------------------------------
DYRK4_Mmus ------------------------------------------------------------
DYRK3_Mmus ------------------------------------------------------------
DYRK2_Mmus ------------------------------------------------------------
mbk-2_Cele -Y------------HSQ-------------------------------------------
C36B7.2_Cele ------------------------------------------------------------
C36B7.1_Cele ------------------------------------------------------------
DYRK4_Hsap ------------------------------------------------------------
DYRK3_Hsap ------------------------------------------------------------
DYRK2_Hsap ------------------------------------------------------------
Dyrk2_Ddis ---------------------------------------------------------SSS
5306_Tthe -QQ---------SQYSN-------------------------------------------
5356_Tthe -QR---------DSKQS-------------------------------------------
5655_Tthe -QQ---------S---T-------------------------------------------
DYRK2_Spur ------------------------------------------------------------
DYRK4_Spur ------------------------------------------------------------
CC1G_13957_Ccin SKRGSLKEKSRDDARASIRKHRSLNVSTSSSTSPRDSKTRERKRESIGLGLAISSSVVSP
AqueK112_Aque ------------------------------------------------------------
AqueK113_Aque ------------------------------------------------------------
DYRK2_b_Smoe ------------------------------------------------------------
DYRK2_a_Smoe ------------------------------------------------------------
GK034_Glam ------------------------------------------------------------
GK033_Glam ------------------------------------------------------------
GK032_Glam ------------------------------------------------------------
smi35A_Dmel ------------------------------------------------------------
Dyrk3_Dmel ------------------------------------------------------------
DYRK4_Mmus ------------------------------------------------------------
DYRK3_Mmus ------------------------------------------------------------
DYRK2_Mmus ------------------------------------------------------------
mbk-2_Cele ------------------------------------------------------------
C36B7.2_Cele ------------------------------------------------------------
C36B7.1_Cele ------------------------------------------------------------
DYRK4_Hsap ------------------------------------------------------------
DYRK3_Hsap ------------------------------------------------------------
DYRK2_Hsap ------------------------------------------------------------
Dyrk2_Ddis KSS-------SNSSSINNNFNNLYSASTFSSSTKKV------------------------
5306_Tthe ------------------------------------------------------------
5356_Tthe ------------------------------------------------------------
5655_Tthe ------------------------------------------------------------
DYRK2_Spur ------------------------------------------------------------
DYRK4_Spur ------------------------------------------------------------
CC1G_13957_Ccin RLAERHSRQAS------------------SS---SVSSPSSEPAPARRVHTTDFSHLPPS
AqueK112_Aque ------------------------------------------------------------
AqueK113_Aque ------------------------------------------------------------
DYRK2_b_Smoe ------------------------------------------------------------
DYRK2_a_Smoe ------------------------------------------------------------
GK034_Glam ------------------------------------------------------------
GK033_Glam ------------------------------------------------------------
GK032_Glam ------------------------------------------------------------
smi35A_Dmel ------------------------------------------------------------
Dyrk3_Dmel ------------------------------------------------------------
DYRK4_Mmus ------------------------------------------------------------
DYRK3_Mmus ------------------------------------------------------------
DYRK2_Mmus ------------------------------------------------------------
mbk-2_Cele ------------------------------------------------------------
C36B7.2_Cele ------------------------------------------------------------
C36B7.1_Cele ------------------------------------------------------------
DYRK4_Hsap ------------------------------------------------------------
DYRK3_Hsap ------------------------------------------------------------
DYRK2_Hsap ------------------------------------------------------------
Dyrk2_Ddis -----------HERPSINPG----------------------------------------
5306_Tthe ------------------------------------------------------------
5356_Tthe ------------------------------------------------------------
5655_Tthe ------------------------------------------------------------
DYRK2_Spur ------------------------------------------------------------
DYRK4_Spur ------------------------------------------------------------
CC1G_13957_Ccin PSSSSIQQFLRQTIPKEPPSLHSPPNVAHSLLRGTQEGWSGLDDEATAEALRKLDGLTGK
AqueK112_Aque ------------------------------------------------------------
AqueK113_Aque ------------------------------------------------------------
DYRK2_b_Smoe ------------------------------------------------------------
DYRK2_a_Smoe ------------------------------------------------------------
GK034_Glam ------------------------------------------------------------
GK033_Glam ------------------------------------------------------------
GK032_Glam ------------------------------------------------------------
smi35A_Dmel ------------------------------------------------------------
Dyrk3_Dmel ------------------------------------------------------------
DYRK4_Mmus ------------------------------------------------------------
DYRK3_Mmus ------------------------------------------------------------
DYRK2_Mmus ------------------------------------------------------------
mbk-2_Cele ------------------------------------------------------------
C36B7.2_Cele ------------------------------------------------------------
C36B7.1_Cele ------------------------------------------------------------
DYRK4_Hsap ------------------------------------------------------------
DYRK3_Hsap ------------------------------------------------------------
DYRK2_Hsap ------------------------------------------------------------
Dyrk2_Ddis ---------------------------------------------------FRKPREALL
5306_Tthe ------------------------------------------------------------
5356_Tthe ------------------------------------------------------------
5655_Tthe ------------------------------------------------------------
DYRK2_Spur ------------------------------------------------------------
DYRK4_Spur ------------------------------------------------------------
CC1G_13957_Ccin TARSRASMTSLGRGSSASRPGTPAKSSQQWEGISGSESVRSKRISTFIREGGKEPRSTPN
AqueK112_Aque ------------------------------------------------------------
AqueK113_Aque ------------------------------------------------------------
DYRK2_b_Smoe ------------------------------------------------------------
DYRK2_a_Smoe ------------------------------------------------------------
GK034_Glam ---------------------------------------------------ARRPYKIGP
GK033_Glam ------------------------------------------------------------
GK032_Glam ------------------------------------------------------------
smi35A_Dmel ------------------------------------------------------------
Dyrk3_Dmel ------------------------------------------------------------
DYRK4_Mmus ------------------------------------------------------------
DYRK3_Mmus ------------------------------------------------------------
DYRK2_Mmus ------------------------------------------------------------
mbk-2_Cele ------------------------------------------------------------
C36B7.2_Cele ------------------------------------------------------------
C36B7.1_Cele ------------------------------------------------------------
DYRK4_Hsap ------------------------------------------------------------
DYRK3_Hsap ------------------------------------------------------------
DYRK2_Hsap ------------------------------------------------------------
Dyrk2_Ddis S--------------GNSDSGIIKKPSS---SSTSSSSS---------------------
5306_Tthe ------------------------------------------------------------
5356_Tthe ------------------------------------------------------------
5655_Tthe ------------------------------------------------------------
DYRK2_Spur ------------------------------------------------------------
DYRK4_Spur ------------------------------------------------------------
CC1G_13957_Ccin PSEGALDSDYVAVSVSGAISSDEPHIIQDKTPKKQSRLSFTPKRGSTSSTTYGSTPTTSS
AqueK112_Aque ------------------------------------------------------------
AqueK113_Aque ------------------------------------------------------------
DYRK2_b_Smoe ------------------------------------------------------------
DYRK2_a_Smoe ------------------------------------------------------------
GK034_Glam T--------------GTSGTNLIFAPAS---SI---------------------------
GK033_Glam ------------------------------------------------------------
GK032_Glam ------------------------------------------------------------
smi35A_Dmel ------------------------------------------------------------
Dyrk3_Dmel ------------------------------------------------------------
DYRK4_Mmus ------------------------------------------------------------
DYRK3_Mmus ------------------------------------------------------------
DYRK2_Mmus ------------------------------------------------------------
mbk-2_Cele ------------------------------------------------------------
C36B7.2_Cele ------------------------------------------------------------
C36B7.1_Cele ------------------------------------------------------------
DYRK4_Hsap ------------------------------------------------------------
DYRK3_Hsap ------------------------------------------------------------
DYRK2_Hsap ------------------------------------------------------------
Dyrk2_Ddis ------------------------------------------------------------
5306_Tthe ------------------------------------------------------------
5356_Tthe ------------------------------------------------------------
5655_Tthe ------------------------------------------------------------
DYRK2_Spur ------------------------------------------------------------
DYRK4_Spur ------------------------------------------------------------
CC1G_13957_Ccin RDSAGTATTNATSVSATSGGRVSSTKARRNSAGSDVSSVHSNDLTLLKDRAAHLAATGEL
AqueK112_Aque ------------------------------------------------------------
AqueK113_Aque ------------------------------------------------------------
DYRK2_b_Smoe ------------------------------------------------------------
DYRK2_a_Smoe ------------------------------------------------------------
GK034_Glam ------------------------------------------------------------
GK033_Glam ------------------------------------------------------------
GK032_Glam ------------------------------------------------------------
smi35A_Dmel ------------------------------------------------------------
Dyrk3_Dmel ------------------------------------------------------------
DYRK4_Mmus ------------------------------------------------------------
DYRK3_Mmus ------------------------------------------------------------
DYRK2_Mmus ------------------------------------------------------------
mbk-2_Cele ------------------------------------------------------------
C36B7.2_Cele ------------------------------------------------------------
C36B7.1_Cele ------------------------------------------------------------
DYRK4_Hsap ------------------------------------------------------------
DYRK3_Hsap ------------------------------------------------------------
DYRK2_Hsap ------------------------------------------------------------
Dyrk2_Ddis ------------------------------------------------------------
5306_Tthe ------------------------------------------------------------
5356_Tthe ------------------------------------------------------------
5655_Tthe ------------------------------------------------------------
DYRK2_Spur ------------------------------------------------------------
DYRK4_Spur ------------------------------------------------------------
CC1G_13957_Ccin IDDAHVPPVPPLPKDLSSYRSPPTTSSTQTFRSIPSVEDPDIRISQDSDIERAFSSDVSA
AqueK112_Aque ------------------------------------------------------------
AqueK113_Aque ------------------------------------------------------------
DYRK2_b_Smoe ------------------------------------------------------------
DYRK2_a_Smoe ------------------------------------------------------------
GK034_Glam ------------------------------------------------------------
GK033_Glam ------------------------------------------------------------
GK032_Glam ------------------------------------------------------------
smi35A_Dmel ------------------------------------------------------------
Dyrk3_Dmel -----------------Q------------------------------------------
DYRK4_Mmus ----------L------QKPSS--------------KN----------------------
DYRK3_Mmus ------------------------------------------------------------
DYRK2_Mmus -----------------G------------------------------------------
mbk-2_Cele ----------N------SLPPNLLGSSQNSASSNSLV-----------------------
C36B7.2_Cele -----------------K------------------------------------------
C36B7.1_Cele -----------------R------------------------------------------
DYRK4_Hsap ----------I------QKPPS--------------NI----------------------
DYRK3_Hsap ------------------------------------------------------------
DYRK2_Hsap -----------------G------------------------------------------
Dyrk2_Ddis ---SSSTTSNI------KAPIQ--------------I-----------------------
5306_Tthe ----------V------LNLLM-----------------------------QQQPTQPPQ
5356_Tthe ----------I------KQPKL--------------TLNTSSHNNTCNLSNNQSFAQST-
5655_Tthe ----------V------LQPSI--------------D--------------IQQYKQPNQ
DYRK2_Spur -----------------T------------------------------------------
DYRK4_Spur ----------A-------SQPI--------------QI----------------------
CC1G_13957_Ccin GKGPRVGSS-A------TRQSQ--------------A-----------------------
AqueK112_Aque ----------Y------NAPPL--------------SI----------------------
AqueK113_Aque -----------------KDPIV--------------D-----------------------
DYRK2_b_Smoe ----------V------QTPSK--------------D--------------WET------
DYRK2_a_Smoe ----------V------QTPSK--------------D--------------WET------
GK034_Glam ------VHKAV------SVPKQ--------------Y-----------------------
GK033_Glam ----------E------KIQSR--------------D--------------FEPHN----
GK032_Glam ----------LLVTYGFT------------------------------------------
smi35A_Dmel ------------------------------------------------------------
Dyrk3_Dmel --------------------------------Y-----------LT------R------C
DYRK4_Mmus --------------------------------KKL--------RVN------R-------
DYRK3_Mmus --------------------------------D-----G--VY-DT------F------M
DYRK2_Mmus --------------------------------A-----G--AP-RS------G------V
mbk-2_Cele ------------------QGHRNPAL-----GS-----G--NT-LT------R------S
C36B7.2_Cele --------------------------------G-----G--V------------------
C36B7.1_Cele ------------------------------------------------------------
DYRK4_Hsap --------------------------------KNS--------RMT------Q-------
DYRK3_Hsap --------------------------------D-----G--VY-DT------F------M
DYRK2_Hsap --------------------------------A-----G--AT-RS------G------V
Dyrk2_Ddis ----------------------SH----------SSNSG--SS-SSGGNNNNS-------
5306_Tthe QHQQIYQNLNNSQQYTTMQQ----SSG--QNY----------------------------
5356_Tthe KHYQGNSSIHISGEKTLTQPNVNPSG-----G----------------------------
5655_Tthe KKRDLVLTLKKSTEN----------LADSFI-----------------------------
DYRK2_Spur --------------------------------A-----L--YP-----------------
DYRK4_Spur --------------------------------NGV---LG-RR--T------NG-----L
CC1G_13957_Ccin ----------------------NP----------NTSEA---------------------
AqueK112_Aque --------------------------------NSV----G-RSKVT------MG-----M
AqueK113_Aque ---------------------FDP--------E-----G--IP-KT------T------T
DYRK2_b_Smoe ------------------------------------------------------------
DYRK2_a_Smoe ------------------------------------------------------------
GK034_Glam ------------------------------------------------------------
GK033_Glam ------------------------------------------------------------
GK032_Glam --------------------------------E-----GDSVHIKT------FTQCNDAL
smi35A_Dmel ------------------------------------------------------------
Dyrk3_Dmel ------------------------------------------------------------
DYRK4_Mmus ------------------------------------------------------------
DYRK3_Mmus MIDETK------------------------------------------------------
DYRK2_Mmus ------------------------------------------------------------
mbk-2_Cele -----YHQPSSTNSST------------NNLY----------------------------
C36B7.2_Cele ------------------------------------------------------------
C36B7.1_Cele ------------------------------------------------------------
DYRK4_Hsap ------------------------------------------------------------
DYRK3_Hsap MIDETK------------------------------------------------------
DYRK2_Hsap ------------------------------------------------------------
Dyrk2_Ddis --------------------------------------------------------DDNS
5306_Tthe ---------------SNQ-SFTTNRQNSNANYL-----YHQLNPPQSTKAADSNRRQNNP
5356_Tthe ---------------INT-NTASNVNNSNSLII-----NHILDSTKSQGGTININANNIS
5655_Tthe -----------------NSCNITQNGSTKSSYVRNNKITQENIAPQQAQNNEP------S
DYRK2_Spur ------------------------------------------------------------
DYRK4_Spur ------------------------------------------------------------
CC1G_13957_Ccin ------------------------------------------------------------
AqueK112_Aque ------------------------------------------------------------
AqueK113_Aque ------------------------------------------------------------
DYRK2_b_Smoe ------------------------------------------------------------
DYRK2_a_Smoe ------------------------------------------------------------
GK034_Glam ------------------------------------------------------------
GK033_Glam IP-EKK------------------------------------------------------
GK032_Glam LVTGSS------------------------------------------------------
smi35A_Dmel ------------------------------------------------------------
Dyrk3_Dmel -----------------------------------------------------------F
DYRK4_Mmus ------------------------------------------------------------
DYRK3_Mmus -----------------------------------------------------------G
DYRK2_Mmus ------------------------------------------------------------
mbk-2_Cele -----------GPLG-------------------------------TISRDLKQSIRDIS
C36B7.2_Cele ------------------------------------------------------------
C36B7.1_Cele ------------------------------------------------------------
DYRK4_Hsap ------------------------------------------------------------
DYRK3_Hsap -----------------------------------------------------------C
DYRK2_Hsap ------------------------------------------------------------
Dyrk2_Ddis --GSSTIKH---------------------------------------------------
5306_Tthe FSGTYSTKNTSAPQQLLKDILSKINKEQVQQQLPYQQNQQVLRSSHMM----NNS---QN
5356_Tthe FHNQYNITNL----------------------------------VSQM----NRK---RQ
5655_Tthe YDEEYI--------------------------SDAK-------FISQI----NRT---KK
DYRK2_Spur ------------------------------------------------------------
DYRK4_Spur ------------------------------------------------------------
CC1G_13957_Ccin ------------------------------------------------------------
AqueK112_Aque ------------------------------------------------------------
AqueK113_Aque -----------------------------------------------------------M
DYRK2_b_Smoe ------------------------------------------------------------
DYRK2_a_Smoe ------------------------------------------------------------
GK034_Glam ------------------------------------------------------------
GK033_Glam -----------------------------------------------------------G
GK032_Glam -----------------------------------------------------------I
smi35A_Dmel ------------------------------------------------------------
Dyrk3_Dmel ------------------------------------------------------EPLA--
DYRK4_Mmus ------------------------------------------------------------
DYRK3_Mmus ------------------------------------------------------PPYS--
DYRK2_Mmus ------------------------------------------------------------
mbk-2_Cele ------------------------------------------------------PPVINS
C36B7.2_Cele ------------------------------------------------------------
C36B7.1_Cele ------------------------------------------------------------
DYRK4_Hsap ------------------------------------------------------------
DYRK3_Hsap ------------------------------------------------------PPCS--
DYRK2_Hsap ------------------------------------------------------------
Dyrk2_Ddis ------------------------------------------------------------
5306_Tthe NSNSNVVILNN---NTQNANNQNIYSSNYVNTNPDLSNIYNPNNLAA-M-----NPQPSS
5356_Tthe PIGGNVIVNNSVGQNTMISNNINQLSANVQN----LNNILNYQNSGASTATNSNAPRSIQ
5655_Tthe ------------------------------------------------------PPQPKK
DYRK2_Spur ------------------------------------------------------------
DYRK4_Spur ------------------------------------------------------------
CC1G_13957_Ccin ------------------------------------------------------------
AqueK112_Aque ------------------------------------------------------------
AqueK113_Aque ------------------------------------------------------TPAQE-
DYRK2_b_Smoe ------------------------------------------------------------
DYRK2_a_Smoe ------------------------------------------------------------
GK034_Glam ------------------------------------------------------------
GK033_Glam L-----------------------------------------------------------
GK032_Glam ------------------------------------------------------EPTV--
smi35A_Dmel ------------------------------------------------------------
Dyrk3_Dmel ------------------------------------------------------------
DYRK4_Mmus ------------------------------------------------------------
DYRK3_Mmus ------------------------------------------------------------
DYRK2_Mmus ------------------------------------------------------------
mbk-2_Cele S--------ANPHL----------------------V-----------------------
C36B7.2_Cele ------------------------------------------------------------
C36B7.1_Cele ------------------------------------------------------------
DYRK4_Hsap ------------------------------------------------------------
DYRK3_Hsap ------------------------------------------------------------
DYRK2_Hsap ------------------------------------------------------------
Dyrk2_Ddis ------------------------------------------------------------
5306_Tthe TKSNRIHSHYFPATTKNKSNRNPSLDKLNDSSFLRLKNVQSPKQRTIRTIMPGSNRDNSV
5356_Tthe -----FHQYGAPNST---------------------------------------------
5655_Tthe G------------------ATVPTNQSI--------NNLQSAQQ----ELQLNYN-NNNI
DYRK2_Spur ------------------------------------------------------------
DYRK4_Spur ------------------------------------------------------------
CC1G_13957_Ccin ------------------------------------------------------------
AqueK112_Aque ------------------------------------------------------------
AqueK113_Aque ------------------------------------------------------------
DYRK2_b_Smoe ------------------------------------------------------------
DYRK2_a_Smoe ------------------------------------------------------------
GK034_Glam ------------------------------------------------------------
GK033_Glam ------------------------------------------------------------
GK032_Glam ------------------------------------------------------------
smi35A_Dmel ------------------------------------------------------------
Dyrk3_Dmel ------------------------------------------------------------
DYRK4_Mmus ------------------------------------------------------------
DYRK3_Mmus ------------------------------------------------------------
DYRK2_Mmus ------------------------------------------------------------
mbk-2_Cele ------------------------------------------------------------
C36B7.2_Cele ------------------------------------------------------------
C36B7.1_Cele ------------------------------------------------------------
DYRK4_Hsap ------------------------------------------------------------
DYRK3_Hsap ------------------------------------------------------------
DYRK2_Hsap ------------------------------------------------------------
Dyrk2_Ddis ------------------------------------------------------------
5306_Tthe GNNSSINRNGYFQREYSESGVDASNQYILPASLLQQK----TKRSGNSITGGVNNVIANN
5356_Tthe ------------------------------------------------------------
5655_Tthe KNGKKI----------------------------SRYGEEYSKRQSFQMNGGKQMYCHNE
DYRK2_Spur ------------------------------------------------------------
DYRK4_Spur ------------------------------------------------------------
CC1G_13957_Ccin ------------------------------------------------------------
AqueK112_Aque ------------------------------------------------------------
AqueK113_Aque ------------------------------------------------------------
DYRK2_b_Smoe ------------------------------------------------------------
DYRK2_a_Smoe ------------------------------------------------------------
GK034_Glam ------------------------------------------------------------
GK033_Glam ------------------------------------------------------------
GK032_Glam ------------------------------------------------------------
smi35A_Dmel ------------------------------------------------------------
Dyrk3_Dmel ------------------------------------------------------------
DYRK4_Mmus ------------------------------------------------------------
DYRK3_Mmus ------------------------------------------------------------
DYRK2_Mmus ------------------------------------------------------------
mbk-2_Cele ----------------------------------------------------NYVQTSSF
C36B7.2_Cele ------------------------------------------------------------
C36B7.1_Cele ------------------------------------------------------------
DYRK4_Hsap ------------------------------------------------------------
DYRK3_Hsap ------------------------------------------------------------
DYRK2_Hsap ------------------------------------------------------------
Dyrk2_Ddis ------------------------------------------------------------
5306_Tthe NNSYNNGSYSKIQPHLPQNQTRQNGTPYVKKDLTIKTGNSIETLKDILSPTNN-------
5356_Tthe ----------------------------------------------------N-------
5655_Tthe QLQIDKCETINIPSHIYSK-------------------------------STN-------
DYRK2_Spur ------------------------------------------------------------
DYRK4_Spur ------------------------------------------------------------
CC1G_13957_Ccin ------------------------------------------------------------
AqueK112_Aque ------------------------------------------------------------
AqueK113_Aque ------------------------------------------------------------
DYRK2_b_Smoe ------------------------------------------------------------
DYRK2_a_Smoe ------------------------------------------------------------
GK034_Glam ------------------------------------------------------------
GK033_Glam ------------------------------------------------------------
GK032_Glam ------------------------------------------------------------
smi35A_Dmel ------------------------------------------------------------
Dyrk3_Dmel ----------------------------M--------------LN---------------
DYRK4_Mmus ------------------------------------------------------------
DYRK3_Mmus ----------------------------D--------------TF---------------
DYRK2_Mmus ---------------G------------T--------------GP---------------
mbk-2_Cele DNGSYEFPSGQAQQQR------------R--------------LG---------------
C36B7.2_Cele ------------------------------------------------------------
C36B7.1_Cele ------------------------------------------------------------
DYRK4_Hsap ------------------------------------------------------------
DYRK3_Hsap ----------------------------N--------------VL---------------
DYRK2_Hsap ---------------G------------T--------------GP---------------
Dyrk2_Ddis ----------------------------TAASLSKMKLSPSHTISDSPRSSTMKSRSVSI
5306_Tthe ------------------------------------------------------------
5356_Tthe ------------------------------------------------------------
5655_Tthe ------------------------------------------------------------
DYRK2_Spur ---------------H------------H--------------GH---------------
DYRK4_Spur ---------------Q------------S---------------E---------------
CC1G_13957_Ccin ------------------------------------------------------------
AqueK112_Aque ---------------S------------S---------------T---------------
AqueK113_Aque ---------------T------------K--------------MF---------------
DYRK2_b_Smoe ------------------------------------------------------------
DYRK2_a_Smoe ------------------------------------------------------------
GK034_Glam ----------------------------------------KHYA----------------
GK033_Glam ---------------GLATRGTIAAAEAA--------------DP---------------
GK032_Glam ----------------------------D--------------VL---------------
smi35A_Dmel -------------------------GS----------RLD-----------L--PQL-C-
Dyrk3_Dmel -------------------------DS----------KED-----------F--PTQ-P-
DYRK4_Mmus ---------------------------------------------------C--PQK-I-
DYRK3_Mmus -------------------------SN----------PSE-----------A--PVS-R-
DYRK2_Mmus -------------------------PS----------PIA-----------L--PPL-R-
mbk-2_Cele -------------------------GS----------QQH-----------L--APL-Q-
C36B7.2_Cele ---------------------------------------ATNGKQHHEWQRV--MTM-R-
C36B7.1_Cele --------------------------------------------------MI--VPA-R-
DYRK4_Hsap ---------------------------------------------------V--FHK-N-
DYRK3_Hsap -------------------------CN----------PSE-----------P--PPP-R-
DYRK2_Hsap -------------------------PS----------PIA-----------L--PPL-R-
Dyrk2_Ddis SNGSLFSPTNTSVNNSNNNTSSNIKTPTKS-SISENLDQN-----------TP-PPPSSS
5306_Tthe ------------------------------------------------------------
5356_Tthe ------------------------------------------------------------
5655_Tthe ------------------------------------------------------------
DYRK2_Spur -------------------------GS----------HVE-----------L--PPI-K-
DYRK4_Spur -------------------------KL----------SNS-----------L--PPA-S-
CC1G_13957_Ccin --------------------VPIVKTPSKKWSFSSALNLK-----------LASSPSSSS
AqueK112_Aque -------------------------GV----------SMA-----------T--RPS---
AqueK113_Aque -------------------------SG----------AVT-----------L--PPL-L-
DYRK2_b_Smoe ------------------------------------------------------------
DYRK2_a_Smoe ------------------------------------------------------------
GK034_Glam ------------------------RDP----------DDK-----------I--EPF-SA
GK033_Glam -------------------------YP----------KVP-----------V--PTM-S-
GK032_Glam -------------------------QT----------HQD-----------P--PLP-Q-
smi35A_Dmel ---------NGSR-----------------------------------------------
Dyrk3_Dmel ---------SN-------------------------------------------------
DYRK4_Mmus ---------PSNT-----------------------------------------------
DYRK3_Mmus ---------RLNI-----------------------------------------------
DYRK2_Mmus ---------ASNA-----------------------------------------------
mbk-2_Cele ---------QTAS-----------------------------------------------
C36B7.2_Cele ----------LDR-----------------------------------------------
C36B7.1_Cele ----------V-S-----------------------------------------------
DYRK4_Hsap ---------TSVT-----------------------------------------------
DYRK3_Hsap ---------RLNM-----------------------------------------------
DYRK2_Hsap ---------ASNA-----------------------------------------------
Dyrk2_Ddis STTKTPTATTTTT-----------------------------------------------
5306_Tthe ---------NANP-----------------------------------------------
5356_Tthe ---------KVNS-----------------------------------------------
5655_Tthe ---------HSA------------------------------------------------
DYRK2_Spur ---------SH-------------------------------------------------
DYRK4_Spur ---------SGQT-----------------------------------------------
CC1G_13957_Ccin TKSSFPL-----------------------------------------------------
AqueK112_Aque ------------------------------------------------------------
AqueK113_Aque ---------KSSS-----------------------------------------------
DYRK2_b_Smoe ------------------------------------------------------------
DYRK2_a_Smoe ------------------------------------------------------------
GK034_Glam AASKDTTSKGSSV-----------------------------------------------
GK033_Glam ---------ASEKQVLSRKITPRALKEFIELKRRIIRLLTQRVAPEADVTVKLLDVLGSF
GK032_Glam ---------EINI-----------------------------------------------
smi35A_Dmel ------------------------------------------------------------
Dyrk3_Dmel ------------------------------------------------------------
DYRK4_Mmus ------------------------------------------------------------
DYRK3_Mmus ------------------------------------------------------------
DYRK2_Mmus ------------------------------------------------------------
mbk-2_Cele ------------------------------------------------------------
C36B7.2_Cele ------------------------------------------------------------
C36B7.1_Cele ------------------------------------------------------------
DYRK4_Hsap ------------------------------------------------------------
DYRK3_Hsap ------------------------------------------------------------
DYRK2_Hsap ------------------------------------------------------------
Dyrk2_Ddis ------------------------------------------------------------
5306_Tthe ------------------------------------------------------------
5356_Tthe ------------------------------------------------------------
5655_Tthe ------------------------------------------------------------
DYRK2_Spur ------------------------------------------------------------
DYRK4_Spur ------------------------------------------------------------
CC1G_13957_Ccin ------------------------------------------------------------
AqueK112_Aque ------------------------------------------------------------
AqueK113_Aque ------------------------------------------------------------
DYRK2_b_Smoe ------------------------------------------------------------
DYRK2_a_Smoe ------------------------------------------------------------
GK034_Glam ------------------------------------------------------------
GK033_Glam KGLVESVPTDDGVPLWTFDWGSAVYFSEHNIGSAASDLNARYIRPQSKAISKRAGSRIIT
GK032_Glam ------------------------------------------------------------
smi35A_Dmel ----------------------------------------------------------R-
Dyrk3_Dmel ------------------------------------------------------------
DYRK4_Mmus ----------------------------------------------------------A-
DYRK3_Mmus ----------------------------------------------------------T-
DYRK2_Mmus ----------------------------------------------------------T-
mbk-2_Cele ----------------------------------------------------------S-
C36B7.2_Cele ----------------------------------------------------------F-
C36B7.1_Cele ----------------------------------------------------------Y-
DYRK4_Hsap ----------------------------------------------------------S-
DYRK3_Hsap ----------------------------------------------------------T-
DYRK2_Hsap ----------------------------------------------------------A-
Dyrk2_Ddis ----------------------------------------------------------T-
5306_Tthe ----------------------------------------------------------K-
5356_Tthe ----------------------------------------------------------S-
5655_Tthe ------------------------------------------------------------
DYRK2_Spur ------------------------------------------------------------
DYRK4_Spur ----------------------------------------------------------T-
CC1G_13957_Ccin ----------------------------------------------------------S-
AqueK112_Aque ----------------------------------------------------------R-
AqueK113_Aque ----------------------------------------------------------N-
DYRK2_b_Smoe ------------------------------------------------------------
DYRK2_a_Smoe ------------------------------------------------------------
GK034_Glam ----------------------------------------------------------T-
GK033_Glam MRAQPSAESPDPGPEQQYVVERSSHYPNVFFMRKSRAYSQAFQALVPSAAPVTLLQSAL-
GK032_Glam ----------------------------------------------------------TQ
smi35A_Dmel -----------------------------------------------------LD-----
Dyrk3_Dmel ------------------------------------------------------------
DYRK4_Mmus -----------------------------------------------------FPF----
DYRK3_Mmus -----------------------------------------------------TEP----
DYRK2_Mmus -----------------------------------------------------TTA----
mbk-2_Cele -----------------------------------------------------LYSNPQS
C36B7.2_Cele -----------------------------------------------------FPV----
C36B7.1_Cele -----------------------------------------------------FPS----
DYRK4_Hsap -----------------------------------------------------LPF----
DYRK3_Hsap -----------------------------------------------------TEQ----
DYRK2_Hsap -----------------------------------------------------AAA----
Dyrk2_Ddis -----------------------------------------------------TTT----
5306_Tthe -----------------------------------------------------TTT----
5356_Tthe -----------------------------------------------------FNQ----
5655_Tthe ------------------------------------------------------------
DYRK2_Spur ------------------------------------------------------------
DYRK4_Spur -----------------------------------------------------FPQ----
CC1G_13957_Ccin -------PRSVGFGHGLRKSSSKEQTSSASSSKAPWSPEQPDAMASAGS----LAS----
AqueK112_Aque -----------------------------------------------------HPT----
AqueK113_Aque -----------------------------------------------------KTV----
DYRK2_b_Smoe ------------------------------------------------------------
DYRK2_a_Smoe ------------------------------------------------------------
GK034_Glam -----------------------------------------------------TQP----
GK033_Glam -----------------------------------------------------NAS----
GK032_Glam NIMGDQAISMVVEGKKQLRDTCMTCDAGDFDRCLSSSKHHPSADVAVSSTAKVVPS----
smi35A_Dmel ---------------------------------------------------G------HN
Dyrk3_Dmel -----------------------------------------------N-I-A--------
DYRK4_Mmus --V--------------------------------------------D--------TKGK
DYRK3_Mmus --L--------------------------------------------T-R-G------HT
DYRK2_Mmus --H--------------------------------------------T-I-G------GS
mbk-2_Cele SSS--------------------------------------------QLL-G------QQ
C36B7.2_Cele --Y--------------------------------------------D--------HRAR
C36B7.1_Cele --F--------------------------------------------R--------AWNR
DYRK4_Hsap --V--------------------------------------------D--------TKGK
DYRK3_Hsap --F--------------------------------------------T-G-D------HT
DYRK2_Hsap --H--------------------------------------------T-I-G------GS
Dyrk2_Ddis -------------------------------------------------S------SSSS
5306_Tthe --A--------------------------------------------T-K-D------SK
5356_Tthe --F--------------------------------------------N-QGG------QT
5655_Tthe ------------------------------------------------------------
DYRK2_Spur -----------------------------------------------T-I-G------AV
DYRK4_Spur --L--------------------------------------------S-L-G-----HNK
CC1G_13957_Ccin -------------------------------------------------L------SSLG
AqueK112_Aque --S--------------------------------------------S-V-E----TRDR
AqueK113_Aque --K---------------------------------------------------------
DYRK2_b_Smoe ------------------------------------------------------------
DYRK2_a_Smoe ------------------------------------------------------------
GK034_Glam --M--------------------------------------------S-S------QRSK
GK033_Glam --K--------------------------------------------R-I-GPLEEDT-S
GK032_Glam --VNATELVLMSDTAQAQSPTEEFYPIPATTIPCEFKPLNAVYLAYHD-I-V------AT
smi35A_Dmel N-----HVAA------------------------------------------------NE
Dyrk3_Dmel --------------------------------------------------------NYP-
DYRK4_Mmus R-----NTV-----------------------------------------NF----PQI-
DYRK3_Mmus Q-----HFVN------------------------------------------------G-
DYRK2_Mmus K-----HTMND---------------------------------------HLHLN--SH-
mbk-2_Cele QAVRPNYAYQQ---------------------------------------SLPRQQHIN-
C36B7.2_Cele R-----EPLHL---------------------------------------SL----PMT-
C36B7.1_Cele K-----EA----------------------------------------------------
DYRK4_Hsap K-----NTV-----------------------------------------SF----PHI-
DYRK3_Hsap Q-----HFLD------------------------------------------------G-
DYRK2_Hsap K-----HTMND---------------------------------------HLHVGSHAH-
Dyrk2_Ddis T-----STN-----------------------------------------TT----PS--
5306_Tthe K-----HLNS----------------------------------------NTL-PIQSY-
5356_Tthe N-----NFMN---------------------------------------------LSSV-
5655_Tthe --------SK----------------------------------------GTKSP-----
DYRK2_Spur K-----KT-NE---------------------------------------------NVP-
DYRK4_Spur S-----NTMGE---------------------------------------SL----PQL-
CC1G_13957_Ccin S-----V-----------------------------------------------------
AqueK112_Aque S-----GT-VP---------------------------------------SL----PQV-
AqueK113_Aque D-----TTFAE---------------------------------------AL----PRL-
DYRK2_b_Smoe ------------------------------------------------------------
DYRK2_a_Smoe ------------------------------------------------------------
GK034_Glam T-----TSV-----------------------------------------RQ----PK--
GK033_Glam D-----TTTLN------------------------------------SLAAI----PTA-
GK032_Glam E-----NVLQNGKLGPTPFSYFYDRTLKVDSNCERVGYTMYPACSDYWVKHRHSGNDAL-
smi35A_Dmel N--------------------------------TVT---TTSLNGN--------G-----
Dyrk3_Dmel G--------------------------------DIQ---ILPIFD---------C-----
DYRK4_Mmus GN-----------------------------KVPSK------------------------
DYRK3_Mmus S--------------------------------EMK---VEQLFQ---------E-----
DYRK2_Mmus G--------------------------------QIQ---VQQLFE---------D-----
mbk-2_Cele S--------------------------------H-Q---TQAFFG---------TVRGPT
C36B7.2_Cele ----------------------------------LSN-----------------------
C36B7.1_Cele ------------------------------------------------------------
DYRK4_Hsap SK-----------------------------KVLLK------------------------
DYRK3_Hsap G--------------------------------EMK---VEQLFQ---------E-----
DYRK2_Hsap G--------------------------------QIQ---VQQLFE---------D-----
Dyrk2_Ddis ---------------------------------KSS---VDDVFA---------R-----
5306_Tthe T--------------------------------TTH---AQQIHQQKRLLQKRDD---QK
5356_Tthe S--------------------------------------TSQNAQ-VNNSQHINN---NN
5655_Tthe ------------------------------------------------------------
DYRK2_Spur T--------------------------------GLQ---VTQLFE---------T-----
DYRK4_Spur TN-----------------------------VQG--------------------------
CC1G_13957_Ccin ------------------------------------------------------------
AqueK112_Aque GN-----------------------------VKDGKS--RDQTWD---------I-----
AqueK113_Aque S--------------------------------GVQ---VQPMFR---------D-----
DYRK2_b_Smoe ------------------------------------------------------------
DYRK2_a_Smoe ------------------------------------------------------------
GK034_Glam ----------------------------------AV---TQTLYQ---------Q-----
GK033_Glam ---------------------------------------ASSLQT---------T-----
GK032_Glam GNESTDEYSQPDDPGRIVYTYDYDNDNILNSTFEIELHSFAQVMQ---------E-----
smi35A_Dmel ------------------------------------------------------------
Dyrk3_Dmel ------------------------------------------------------------
DYRK4_Mmus ------------------------------------------------------------
DYRK3_Mmus ------------------------------------------------------------
DYRK2_Mmus ------------------------------------------------------------
mbk-2_Cele NST------------------N----------------------------------IVTP
C36B7.2_Cele ------------------------------------------------------------
C36B7.1_Cele ------------------------------------------------------------
DYRK4_Hsap ------------------------------------------------------------
DYRK3_Hsap ------------------------------------------------------------
DYRK2_Hsap ------------------------------------------------------------
Dyrk2_Ddis ------------------------------------------------------------
5306_Tthe NKS------------------NFINSSFQ--------------------------YIMAS
5356_Tthe NGSNPIRRSKYKINTETINTQN------DYSLTIDHSGGSIPRYPQTETHKTGTKEIIIP
5655_Tthe ------------------------------------------------------------
DYRK2_Spur ------------------------------------------------------------
DYRK4_Spur ------------------------------------------------------------
CC1G_13957_Ccin ------------------------------------------------------------
AqueK112_Aque ------------------------------------------------------------
AqueK113_Aque ------------------------------------------------------------
DYRK2_b_Smoe ------------------------------------------------------------
DYRK2_a_Smoe ------------------------------------------------------------
GK034_Glam ------------------------------------------------------------
GK033_Glam ------------------------------------------------------------
GK032_Glam ------------------------------------------------------------
smi35A_Dmel ------------------------------------------------------------
Dyrk3_Dmel ------------------------------------------------------------
DYRK4_Mmus ------------------------------------------------------------
DYRK3_Mmus ------------------------------------------------------------
DYRK2_Mmus ------------------------------------------------------------
mbk-2_Cele --LRASKTMIDV------------------------------------------------
C36B7.2_Cele ------------------------------------------------------------
C36B7.1_Cele ------------------------------------------------------------
DYRK4_Hsap ------------------------------------------------------------
DYRK3_Hsap ------------------------------------------------------------
DYRK2_Hsap ------------------------------------------------------------
Dyrk2_Ddis ------------------------------------------------------------
5306_Tthe ENNS-----VENTNRFSYNVMNNMVANNQGQKLLKNKNNSMENQQFKNLSFTQPLN----
5356_Tthe QSNK-----IEQI--------------------SN-RY--------NLTSTNKPNSRMHL
5655_Tthe ------------------------------------------------------------
DYRK2_Spur ------------------------------------------------------------
DYRK4_Spur ------------------------------------------------------------
CC1G_13957_Ccin ------------------------------------------------------------
AqueK112_Aque ------------------------------------------------------------
AqueK113_Aque ------------------------------------------------------------
DYRK2_b_Smoe ------------------------------------------------------------
DYRK2_a_Smoe ------------------------------------------------------------
GK034_Glam ------------------------------------------------------------
GK033_Glam ------------------------------------------------------------
GK032_Glam ------------------------------------------------------------
smi35A_Dmel ------------------NGNGN--SN---------------------------------
Dyrk3_Dmel ------------------CEISE-SI----------------------------------
DYRK4_Mmus ------------------------------------------------------------
DYRK3_Mmus ------------------FGNRR-------------------------------------
DYRK2_Mmus ------------------NSNKR-TVL---------------------------------
mbk-2_Cele ------------------LAPVR-DTV---------------------------------
C36B7.2_Cele ------------------------------------------------------------
C36B7.1_Cele ------------------------------------------------------------
DYRK4_Hsap ------------------------------------------------------------
DYRK3_Hsap ------------------FGNRK-------------------------------------
DYRK2_Hsap ------------------NSNKR-TVL---------------------------------
Dyrk2_Ddis ------------------LANVSKPAIKSRSL----------------------------
5306_Tthe ----------------DQF-----------------------------------------
5356_Tthe MIGTENDQSQNQMGGLKDF-----------------------------------------
5655_Tthe ------------------------------------------------------------
DYRK2_Spur ------------------DDNHN-FKR---------------------------------
DYRK4_Spur ------------------------------------------------------------
CC1G_13957_Ccin ---------------------------RNHSLHPDTSKTPDKNRPGTGSSVSTAGLSAPS
AqueK112_Aque ------------------YGDTE-QLL---------------------------------
AqueK113_Aque ------------------QVPLN-DLQ---------------------------------
DYRK2_b_Smoe ------------------F-----------------------------------------
DYRK2_a_Smoe ------------------F-----------------------------------------
GK034_Glam ------------------QQE--ASLL---------------------------------
GK033_Glam ------------------MGQQL-------------------------------------
GK032_Glam ------------------MG----------------------------------------
smi35A_Dmel -------------------------------------SN---------------------
Dyrk3_Dmel ------------------------------------------------------------
DYRK4_Mmus --------------------------------------G---------------------
DYRK3_Mmus ------------------------------------------------------------
DYRK2_Mmus -------------------------------------TT---------------------
mbk-2_Cele -------------------------------------A----------------------
C36B7.2_Cele ------------------------------------------------------------
C36B7.1_Cele ------------------------------------------------------------
DYRK4_Hsap --------------------------------------S---------------------
DYRK3_Hsap ------------------------------------------------------------
DYRK2_Hsap -------------------------------------TT---------------------
Dyrk2_Ddis ---SVSASLAR----------VEQSPPTKDKGDKESSSSSSSS--------------SSS
5306_Tthe --------------------------------------K---------------------
5356_Tthe --------------------------------------L---------------------
5655_Tthe ------------------------------------------------------------
DYRK2_Spur -------------------------------------QV---------------------
DYRK4_Spur -----------------------------------HLVA---------------------
CC1G_13957_Ccin GPLSPSASIKRAQSKRLTPSSI----PFFR---RSS------SQSMQVPSSSGSGHPSSP
AqueK112_Aque -------------LSPYSSRPRPSPSLIPRLKPSGSCRR---------------------
AqueK113_Aque -------------------------------------QR---------------------
DYRK2_b_Smoe --------------------------------------M---------------------
DYRK2_a_Smoe --------------------------------------M---------------------
GK034_Glam ------------------------------HGNKL----------------------GAN
GK033_Glam ------------------------------------------------------------
GK032_Glam ------------------------------------------------------------
smi35A_Dmel -----N--N-------------NNIG-S--P-V---------------------------
Dyrk3_Dmel -----Q--A-------------I-S--L--P-N---------------------------
DYRK4_Mmus -----PM---------------Q-Y--Q--E-----------------------------
DYRK3_Mmus ------S-N-------------T-L--Q--S-D---------------------------
DYRK2_Mmus -----Q------------------------P-N---------------------------
mbk-2_Cele ------------------------A--Q--A-T---------------------------
C36B7.2_Cele ----------------------S-YRYQLTA-R---------------------------
C36B7.1_Cele -----------------------------SM-N---------------------------
DYRK4_Hsap -----SL---------------L-Y--Q--E-----------------------------
DYRK3_Hsap ------S-N-------------T-I--Q--S-D---------------------------
DYRK2_Hsap -----Q------------------------P-N---------------------------
Dyrk2_Ddis FSSKFTKILRSSSKTPTPTSSNTTV--Q--PSTTSLSASKISSRKDTKSL-SSFSTTT--
5306_Tthe -----Q------------------------------------------------------
5356_Tthe -----S------------------------P-Q---------------------------
5655_Tthe ------------------------------------------------------------
DYRK2_Spur -----Q--N-------------K-V--I--A-N---------------------------
DYRK4_Spur -----SG---------------I-H--Q--TTI---------------------------
CC1G_13957_Ccin PPSMPTKASRSKASTPPHD----------------ISMTSVST-PGKKASVLSLGLPSLL
AqueK112_Aque -----SP---------------S-K--Q--TTA---------------------------
AqueK113_Aque -----RP-R-------------Q-S--T--A-D---------------------------
DYRK2_b_Smoe -----T------------------------P-E---------------------------
DYRK2_a_Smoe -----T------------------------P-E---------------------------
GK034_Glam YAGKNQPIVYIKSKPPSTTNSRT-T--T--PKR---------------------------
GK033_Glam -----S--S-------------T-L--QE-S-Q---------------------------
GK032_Glam ------S-N-------------P-L--G--T-D---------------------------
smi35A_Dmel ------------------------------------------------------------
Dyrk3_Dmel ------------------------------------------------------------
DYRK4_Mmus ------------------------------------------------------------
DYRK3_Mmus ------------------------------------------------------------
DYRK2_Mmus ------------------------------------------------------------
mbk-2_Cele ------------------------------------------------------------
C36B7.2_Cele ------------------------------------------------------------
C36B7.1_Cele ------------------------------------------------------------
DYRK4_Hsap ------------------------------------------------------------
DYRK3_Hsap ------------------------------------------------------------
DYRK2_Hsap ------------------------------------------------------------
Dyrk2_Ddis ------------------------------------------------------------
5306_Tthe ------------------------------------------------------------
5356_Tthe ------------------------------------------------------------
5655_Tthe ------------------------------------------------------------
DYRK2_Spur ------------------------------------------------------------
DYRK4_Spur ------------------------------------------------------------
CC1G_13957_Ccin KSSSRRSLHSDAKEAAKELQKAKEAARESDREKAKAEKAEKERQKKEDKDRSESRISVLI
AqueK112_Aque ------------------------------------------------------------
AqueK113_Aque ------------------------------------------------------------
DYRK2_b_Smoe ------------------------------------------------------------
DYRK2_a_Smoe ------------------------------------------------------------
GK034_Glam ------------------------------------------------------------
GK033_Glam ------------------------------------------------------------
GK032_Glam ------------------------------------------------------------
smi35A_Dmel --------------------------------------------------------S---
Dyrk3_Dmel --------------------------------------------------------V---
DYRK4_Mmus ------------------------------------------------------------
DYRK3_Mmus --------------------------------------------------------GI--
DYRK2_Mmus --------------------------------------------------------GL--
mbk-2_Cele --------------------------------------------------------GL--
C36B7.2_Cele --------------------------------------------------------NM--
C36B7.1_Cele --------------------------------------------------------HL--
DYRK4_Hsap ------------------------------------------------------------
DYRK3_Hsap --------------------------------------------------------GI--
DYRK2_Hsap --------------------------------------------------------GL--
Dyrk2_Ddis ------------------------------------------------TTTTLKSSSS--
5306_Tthe ----------------------------------------------------------TK
5356_Tthe --------------------------------------------------------GAAF
5655_Tthe ----------------------------------------------------------FQ
DYRK2_Spur --------------------------------------------------------GH--
DYRK4_Spur --------------------------------------------------------GE--
CC1G_13957_Ccin SRKRGKTLSATDPRKPKSPVTLPPMQISAIEPVTAQRVAKLKSSSSQSTTSSINSRTSS-
AqueK112_Aque --------------------------------------------------------GA--
AqueK113_Aque ------------------------------------------------------------
DYRK2_b_Smoe --------------------------------------------------------GK--
DYRK2_a_Smoe --------------------------------------------------------GK--
GK034_Glam --------------------------------------------------------GA--
GK033_Glam --------------------------------------------------------GI--
GK032_Glam --------------------------------------------------------DL--
smi35A_Dmel ------SS-----T----------T-----------------------------------
Dyrk3_Dmel ----T-SP-----S----------KT----------------------------------
DYRK4_Mmus ------NQ-----I----------H-----------------------------------
DYRK3_Mmus ----S-NS-----E----------K-----------------------------------
DYRK2_Mmus ----T-TV-----G----------K-----------------------------------
mbk-2_Cele ----P-NV-----G----------TSSSNGSSNSSSGVGSGGSGSLMTQSIGGPNKHLSA
C36B7.2_Cele ----S-CS-----M----------T-----------------------------------
C36B7.1_Cele -------T-----L----------S-----------------------------------
DYRK4_Hsap ------NQ-----A----------H-----------------------------------
DYRK3_Hsap ----S-DS-----E----------K-----------------------------------
DYRK2_Hsap ----T-TV-----G----------K-----------------------------------
Dyrk2_Ddis ----S-SSSSSSSS----------K-----------------------------------
5306_Tthe ENNNT-QN-----S----------------------------------------------
5356_Tthe ---IK-SN-----V----------------------------------------------
5655_Tthe INPTP-TN-----S----------------------------------------------
DYRK2_Spur ----L-SH-----D----------A-----------------------------------
DYRK4_Spur ----HIK------A----------H-----------------------------------
CC1G_13957_Ccin ----S-SSRVTSQT----------A-----------------------------------
AqueK112_Aque ----SVPD-----P----------H-----------------------------------
AqueK113_Aque ------------------------------------------------------------
DYRK2_b_Smoe ------------------------------------------------------------
DYRK2_a_Smoe ------------------------------------------------------------
GK034_Glam ----S-TS-----T----------R-----------------------------------
GK033_Glam ----F-GL-----S----------S-----------------------------------
GK032_Glam ----L-PV-----EKPAVALGDQYT-----------------------------------
smi35A_Dmel -----------------------------N---S--------------------------
Dyrk3_Dmel -----------------------------K---D--------------------------
DYRK4_Mmus -----------------------------N---Q--------------------------
DYRK3_Mmus ---------------------------------S--------------------------
DYRK2_Mmus -----------------------------T---G--------------------------
mbk-2_Cele SHSTLNTASTHDMMH--------------S---K--------------------------
C36B7.2_Cele -----------------------------A---R--------------------------
C36B7.1_Cele -----------------------------R---W--------------------------
DYRK4_Hsap -----------------------------N---Q--------------------------
DYRK3_Hsap ---------------------------------C--------------------------
DYRK2_Hsap -----------------------------T---G--------------------------
Dyrk2_Ddis -----------------------------S---NIASSSSSSSNNLTNLLTQSQS-----
5306_Tthe --------------N--------------N---K--------------------------
5356_Tthe --------------SSKSTQRNYSNKNRYL---G--------------------------
5655_Tthe --------------N--------------N---N--------------------------
DYRK2_Spur -----------------------------N---A--------------------------
DYRK4_Spur -----------------------------R------------------------------
CC1G_13957_Ccin -----------------------------S---SMQKISDSSLRSRTQLPTI-AGSPSVG
AqueK112_Aque -----------------------------S-RGR--------------------------
AqueK113_Aque ---------------------------------T--------------------------
DYRK2_b_Smoe ------------------------------------------------------------
DYRK2_a_Smoe ------------------------------------------------------------
GK034_Glam -----------------------------S---ERTASTS--------------------
GK033_Glam -----------------------------TNPLQ--------------------------
GK032_Glam -----------------------------T---V--------------------------
smi35A_Dmel ------------------------------------SNG--G------------------
Dyrk3_Dmel ------------------------------------VPG--L------------------
DYRK4_Mmus ------------------------------------VLS--S------------------
DYRK3_Mmus ------------------------------------SPA---------------------
DYRK2_Mmus ------------------------------------LPG--V------------------
mbk-2_Cele ------------------------------------IPK--S------------------
C36B7.2_Cele ------------------------------------EPA--DL-----------------
C36B7.1_Cele ------------------------------------------------------------
DYRK4_Hsap ------------------------------------MPA--S------------------
DYRK3_Hsap ------------------------------------SPT--V------------------
DYRK2_Hsap ------------------------------------LPV--V------------------
Dyrk2_Ddis ------------------ISSTSTSTTTTPTS---TSPT--LAS----------------
5306_Tthe ------------------------------------ILT--V------------------
5356_Tthe ------------------------------------LNK--I------------------
5655_Tthe ------------------------------------NSK--K------------------
DYRK2_Spur ------------------------------------LPD--V------------------
DYRK4_Spur ------------------------------------------------------------
CC1G_13957_Ccin TNGTNSTQNTIREKDHSSLLSSSI--SGLPKETPTKIPR--ISSRTSAAPSPSGKSTSTF
AqueK112_Aque -----------------------------------LYRS--T------------------
AqueK113_Aque ------------------------------------LPN--L------------------
DYRK2_b_Smoe ------------------------------------------------------------
DYRK2_a_Smoe ------------------------------------------------------------
GK034_Glam -----------------------------------VSPR--AVA----------------
GK033_Glam ------------------------------------VPSQVQ------------------
GK032_Glam ------------------------------------TPT--S------------------
smi35A_Dmel ---------------------------------------------------------N--
Dyrk3_Dmel ---------------------------------------------------------F--
DYRK4_Mmus ---------------------------------------------------------E--
DYRK3_Mmus ------------------------------------------------------------
DYRK2_Mmus ---------------------------------------------------------P--
mbk-2_Cele ---------------------------------------------------------P--
C36B7.2_Cele ---------------------------------------------------------R--
C36B7.1_Cele ------------------------------------------------------------
DYRK4_Hsap ---------------------------------------------------------E--
DYRK3_Hsap ------------------------------------------------------------
DYRK2_Hsap ---------------------------------------------------------P--
Dyrk2_Ddis -------------------------------------------SMSVLSS-------P--
5306_Tthe ---------------------------------------------------KQQQ--Q--
5356_Tthe ---------------------------------------------------QAQQQNS--
5655_Tthe ---------------------------------------------------------P--
DYRK2_Spur ------------------------------------------------------------
DYRK4_Spur ------------------------------------------------------------
CC1G_13957_Ccin ASRRTSMNPAASSSTNPSPISLSTNEFGVIDNEDGATPRNLARQSSIRASPSTSASRP--
AqueK112_Aque ---------------------------------------------------------S--
AqueK113_Aque ---------------------------------------------------------H--
DYRK2_b_Smoe ------------------------------------------------------------
DYRK2_a_Smoe ------------------------------------------------------------
GK034_Glam -------------------------------------------TKLSQRT-------P--
GK033_Glam ---------------------------------------------------------PKM
GK032_Glam ---------------------------------------------------------P--
smi35A_Dmel -------E-------------------------------------RGS-------S--T-
Dyrk3_Dmel -------L-------------------------RTISENSKSKSEP---------E--C-
DYRK4_Mmus -------L-------------------------------------K-T------SE--I-
DYRK3_Mmus ------------------------------------------------------------
DYRK2_Mmus -------E-------------------------------------R---------Q--L-
mbk-2_Cele -------S-------------------------------------N--------------
C36B7.2_Cele -------E-------------------------------------D---------S--F-
C36B7.1_Cele ------------------------------------------------------------
DYRK4_Hsap -------L-------------------------------------K-A------SE--I-
DYRK3_Hsap ------------------------------------------------------------
DYRK2_Hsap -------E-------------------------------------R---------Q--L-
Dyrk2_Ddis -------T-------------------------------------S---------T----
5306_Tthe -------K--------------------QQ--LQFIQKG-LGQ-----------------
5356_Tthe -------S--------------------QSRVRSNIKQMSKDK-----------------
5655_Tthe -------K--------------------LS--LNSVHLNNRAS-----------------
DYRK2_Spur ------------------------------------------------------------
DYRK4_Spur ------------------------------------------------------------
CC1G_13957_Ccin -------ARQSSANTSSTSSSALRKSTRES--VSFIGLR-KASTSS---------V----
AqueK112_Aque -------L-------------------------------------R-SDSDLDGDS--L-
AqueK113_Aque -------H-------------------------------------N---------R--P-
DYRK2_b_Smoe ------------------------------------------------------------
DYRK2_a_Smoe ------------------------------------------------------------
GK034_Glam -------S-------------------------------------S---------K--G-
GK033_Glam GVLASKIR-------------------------------------N---------QHSL-
GK032_Glam -------Q-------------------------------------A---------H--GD
smi35A_Dmel K--SN-S-SSGS------------------------------------------------
Dyrk3_Dmel E--SL-I-S-VKE------SSVMENHTFLFH-----------------------------
DYRK4_Mmus P--F----N-IN------------------------------------------------
DYRK3_Mmus ---SQ-G-K-SS------------------------------------------------
DYRK2_Mmus E--SI-H-R-RQ------------------------------------------------
mbk-2_Cele E--SL-S-R-SH------------------------------------------------
C36B7.2_Cele K--RI-V-R-KR------------------------------------------------
C36B7.1_Cele ------------------------------------------------------------
DYRK4_Hsap P--F----H-PS------------------------------------------------
DYRK3_Hsap ---SQ-G-K-SS------------------------------------------------
DYRK2_Hsap D--SI-H-R-RQ------------------------------------------------
Dyrk2_Ddis ----------TT------------------------------------------------
5306_Tthe ---NS-------SKQN---QS------SIQTS------EGNENKSESNYESQGQNLDNFD
5356_Tthe ---AL-------SV--DKTSN------YINRRDSTQNQNGNYI-----------------
5655_Tthe ---SF-------SVEDENQVK------FMKNV------ESFTNQQQTKLKSLRQILNDTT
DYRK2_Spur -----------K------------------------------------------------
DYRK4_Spur --------Q-PN------------------------------------------------
CC1G_13957_Ccin ----------NS------------------------------------------------
AqueK112_Aque PIPGIGG-V-PA------------------------------------------------
AqueK113_Aque L--TS-A-Q-P-------------------------------------------------
DYRK2_b_Smoe ---TI-------------------------------------------------------
DYRK2_a_Smoe ---TI-------------------------------------------------------
GK034_Glam R--GV-V-A-AT------------------------------------------------
GK033_Glam S--AE-ESR-MQ------------------------------------------------
GK032_Glam N--TI-A-E-VE------------------------------------------------
smi35A_Dmel -------------------------------------------------------GSSG-
Dyrk3_Dmel -----------------------------------------------------EQIIMS-
DYRK4_Mmus -------------------------------------------------------TKAQ-
DYRK3_Mmus -------------------------------------------------------ESLS-
DYRK2_Mmus -------------------------------------------------------GSST-
mbk-2_Cele -------------------------------------------------------TSSSG
C36B7.2_Cele ---------------------------------------------------------AQ-
C36B7.1_Cele ----------------------------------------------------------Q-
DYRK4_Hsap -------------------------------------------------------IKTQ-
DYRK3_Hsap -------------------------------------------------------DCLN-
DYRK2_Hsap -------------------------------------------------------GSST-
Dyrk2_Ddis -------------------------------------------------------TSTS-
5306_Tthe QHKIDLSTASQTPFRNGNS------------------TNEKKTLD-----DNNTRNTERD
5356_Tthe QDKSSLLQTLQPPASQSYDQGGDNAYYKHNTLQDEQLGSTYYTIDNQNLQQPTIQSSGSS
5655_Tthe ---------------------------------------------------DQRQNT-HA
DYRK2_Spur -------------------------------------------------------RP-A-
DYRK4_Spur -------------------------------------------------------KFEE-
CC1G_13957_Ccin -------------------------------------------------------TSTP-
AqueK112_Aque -------------------------------------------------------AVPS-
AqueK113_Aque -------------------------------------------------------QSMT-
DYRK2_b_Smoe ------------------------------------------------------------
DYRK2_a_Smoe ------------------------------------------------------------
GK034_Glam -------------------------------------------------------TTPA-
GK033_Glam -------------------------------------------------------ASTK-
GK032_Glam -------------------------------------------------------FTAD-
smi35A_Dmel N-SA--SS---------------------------------TGSG---------------
Dyrk3_Dmel G-QQ--KC---------------------------------ELHE---------------
DYRK4_Mmus D-TK--PH---------------------------------PELQ---------------
DYRK3_Mmus A-VK--CN---------------------------------LSSR---------------
DYRK2_Mmus S-LK--SM---------------------------------EGMG---------------
mbk-2_Cele G-SQ--GG---------------------------------HNSN---------------
C36B7.2_Cele N-HC--VD---------------------------------QTVY---------------
C36B7.1_Cele ---V--AG---------------------------------VSQQ---------------
DYRK4_Hsap D-PK--AE---------------------------------EKSP---------------
DYRK3_Hsap T-VK--SN---------------------------------SSSK---------------
DYRK2_Hsap S-LK--SM---------------------------------EGMG---------------
Dyrk2_Ddis T-TS--TT---------------------------------TTPT---------------
5306_Tthe E-KK--EE---------------------------------PLDW---------------
5356_Tthe K-LE--EK---------------------------------HLTW---------------
5655_Tthe S-VI--ST---------------------------------NNDQ---------------
DYRK2_Spur S-DG--SK---------------------------------NGSA---------------
DYRK4_Spur I-KR--SS---------------------------------KNEG---------------
CC1G_13957_Ccin GTSGTTSE---------------------------------SSGSHRFSALSPSKGLKLL
AqueK112_Aque T-SR--SR---------------------------------RNPQ---------------
AqueK113_Aque D-DA--SS---------------------------------DQSQ---------------
DYRK2_b_Smoe ------------------------------------------VYY---------------
DYRK2_a_Smoe ------------------------------------------VYY---------------
GK034_Glam D-QN--RS---------------------------------QLKG---------------
GK033_Glam E-NK-DSM---------------------------------KFRV---------------
GK032_Glam D-EG--AMDNSTDEQAPGYVPVGDNMDPGLIDQQVLHNAEAPGLN---------------
smi35A_Dmel ------------------------------------------------------------
Dyrk3_Dmel ------------------------------------------------------------
DYRK4_Mmus ------------------------------------------------------------
DYRK3_Mmus ------------------------------------------------------------
DYRK2_Mmus ------------------------------------------------------------
mbk-2_Cele ------------------------------------------------------------
C36B7.2_Cele ------------------------------------------------------------
C36B7.1_Cele ------------------------------------------------------------
DYRK4_Hsap ------------------------------------------------------------
DYRK3_Hsap ------------------------------------------------------------
DYRK2_Hsap ------------------------------------------------------------
Dyrk2_Ddis ------------------------------------------------------------
5306_Tthe ------------------------------------------------------------
5356_Tthe ------------------------------------------------------------
5655_Tthe ------------------------------------------------------------
DYRK2_Spur ------------------------------------------------------------
DYRK4_Spur ------------------------------------------------------------
CC1G_13957_Ccin GPKSSRSAASSSQNLRQNMSSPSSSRQSLSTPSPVPSTVDEDELLGDEEMMNYIRRQQAK
AqueK112_Aque ------------------------------------------------------------
AqueK113_Aque ------------------------------------------------------------
DYRK2_b_Smoe ------------------------------------------------------------
DYRK2_a_Smoe ------------------------------------------------------------
GK034_Glam ------------------------------------------------------------
GK033_Glam ------------------------------------------------------------
GK032_Glam ------------------------------------------------------------
smi35A_Dmel ----------------E---LKCNTP------------------MTPSELVK-KF-RN-Y
Dyrk3_Dmel --------------------KPKVLV------------------VSPQQVMI-LY-MN-K
DYRK4_Mmus --------------------KKHKVP------------------LTVAEALK-FF-KN-Q
DYRK3_Mmus --------------------PSKVLP------------------LTPEQALK-QY-KH-H
DYRK2_Mmus --------------------KVKASP------------------MTPEQAMK-QY-MQ-K
mbk-2_Cele --------------------SGSNSG------------------FRPEDAVQ-TF-GA-K
C36B7.2_Cele --------------------PNENPG------------------LSPSSIFN-GY-SH-L
C36B7.1_Cele --------------------DEACSG------------------LIPQQASL-VY-LH-Q
DYRK4_Hsap --------------------KKQKVT------------------LTAAEALK-LF-KN-Q
DYRK3_Hsap --------------------APKVVP------------------LTPEQALK-QY-KH-H
DYRK2_Hsap --------------------KVKATP------------------MTPEQAMK-QY-MQ-K
Dyrk2_Ddis --------------------KSSCTI------------------ITPSIALK-LY-IN-D
5306_Tthe --------------------EKVKVP------------------ITPLEVLA-KY-QK-Y
5356_Tthe --------------------EDLKLP------------------VGPDDVLN-KY-GHEF
5655_Tthe --------------------LILN-T------------------ENTNNILT-QS-KE-N
DYRK2_Spur --------------------KGRALP------------------MTPEESMK-LY-MH-K
DYRK4_Spur --------------------KDSRGH------------------MKPNEAMM-YY-RD-K
CC1G_13957_Ccin KKAAGATQEELEEMLKFPEPTPPVPP------------------ASPHHVLK-SSQAQ-Y
AqueK112_Aque --------------------QSIRLP------------------MTPSQAIK-EY-GH-R
AqueK113_Aque --------------------SQKQRY------------------LTPDQAIK-LY-GS-K
DYRK2_b_Smoe --------------------STWLNC------------------FVRSAVLK-QY-PS-S
DYRK2_a_Smoe --------------------STWLNC------------------FVRSAVLK-QY-PS-S
GK034_Glam --------------------SAFPRE------------------ITAAEVLS-SH-KS-D
GK033_Glam --------------------VQNATPSTTKVESVNYRDLIMEHLSSPQATIEAKL-Q-SA
GK032_Glam --------------------REKAPE------------------HMPEAAFK-S-HIA-K
smi35A_Dmel LTDLEFEE---------------LKVYK-EV---WYFGQ------HASKNYNKP------
Dyrk3_Dmel LTPYERTE---------------ILTYP-QI---YFIGA------NAKKRPG--------
DYRK4_Mmus LSPYEQSE---------------ILGYS-EL---WFLGL------EAKKLNV--------
DYRK3_Mmus LTAYEKLE---------------IVSYP-EI---YFVGP------NAKKRQG--------
DYRK2_Mmus LTAFEHHE---------------IFSYP-EI---YFLGP------NAKKRQG--------
mbk-2_Cele LVPFEKNE---------------IYNYT-RV---FFVGS------HAKKQAG--------
C36B7.2_Cele LSPFEKIE---------------VKKYG-KI---YALSM------NPETLKA--------
C36B7.1_Cele LTSYEKRE---------------IEDYP-IV---YTVGD------YGSKNQT--------
DYRK4_Hsap LSPYEQSE---------------ILGYA-EL---WFLGL------EAKKLDT--------
DYRK3_Hsap LTAYEKLE---------------IINYP-EI---YFVGP------NAKKRHG--------
DYRK2_Hsap LTAFEHHE---------------IFSYP-EI---YFLGL------NAKKRQG--------
Dyrk2_Ddis LTSAEQSE---------------ILDYP-QI---YFTGN------TNKKTKF--------
5306_Tthe LTPQEKAE---------------ILEFK-RI---YFIGH------NANKA----------
5356_Tthe LTDYEKKE---------------ILQYM-NI---YYVGH------KAKKPARSE------
5655_Tthe LNIDINSE---------------IKDWALVI---YFIGH------QCKKKFQ--------
DYRK2_Spur LTSYEHHE---------------IFNYP-HI---YFTGP------NAKKRQG--------
DYRK4_Spur LTVFEEAE---------------ILDYQ-EV---WFLGP------EAKKVEG--------
CC1G_13957_Ccin LSDYERKE---------------ILDYP-SV---YFIGA------KSRKKMA--------
AqueK112_Aque LTGYEKKE---------------ILEYP-DV---WFLGL------ESKKIEG--------
AqueK113_Aque LSEFEQQE---------------IQAFQ-QV---YFVGQ------HAKKRQG--------
DYRK2_b_Smoe LTDFEKQE---------------ILKYP-EI---YYIGL------PQKKIQV--------
DYRK2_a_Smoe LTDFEKQE---------------ILKYP-EI---YYIGL------PQKKIQV--------
GK034_Glam LTPFEQSE---------------IQRFA-KI---YYWGQ------QANKQY---------
GK033_Glam LTADERQKFDSTVRSFAEKLRAKELSY-SSILSNLFDGL------SAPSGSQVQ------
GK032_Glam K--IEETE---------------RAVTP------YVVRKQSAIRHRDKDRQYIVTGDTMR
:
smi35A_Dmel ------------------------------------------------------------
Dyrk3_Dmel ------------------------------------------------------------
DYRK4_Mmus ------------------------------------------------------------
DYRK3_Mmus ------------------------------------------------------------
DYRK2_Mmus ------------------------------------------------------------
mbk-2_Cele ------------------------------------------------------------
C36B7.2_Cele ------------------------------------------------------------
C36B7.1_Cele ------------------------------------------------------------
DYRK4_Hsap ------------------------------------------------------------
DYRK3_Hsap ------------------------------------------------------------
DYRK2_Hsap ------------------------------------------------------------
Dyrk2_Ddis ------------------------------------------------------------
5306_Tthe ------------------------------------------------------------
5356_Tthe ------------------------------------------------------------
5655_Tthe ------------------------------------------------------------
DYRK2_Spur ------------------------------------------------------------
DYRK4_Spur ------------------------------------------------------------
CC1G_13957_Ccin ------------------------------------------------------------
AqueK112_Aque ------------------------------------------------------------
AqueK113_Aque ------------------------------------------------------------
DYRK2_b_Smoe ------------------------------------------------------------
DYRK2_a_Smoe ------------------------------------------------------------
GK034_Glam ------------------------------------------------------------
GK033_Glam ------GSGRPGSNYGQSTSSLPTGIEQFSSRGDSDTRTDPSDHDFDSDMALSGNEEYED
GK032_Glam ADVLQQI-----------------------------------------------------
smi35A_Dmel ------------------------------------------------------------
Dyrk3_Dmel ------------------------------------------------------------
DYRK4_Mmus ------------------------------------------------------------
DYRK3_Mmus ------------------------------------------------------------
DYRK2_Mmus ------------------------------------------------------------
mbk-2_Cele ------------------------------------------------------------
C36B7.2_Cele ------------------------------------------------------------
C36B7.1_Cele ------------------------------------------------------------
DYRK4_Hsap ------------------------------------------------------------
DYRK3_Hsap ------------------------------------------------------------
DYRK2_Hsap ------------------------------------------------------------
Dyrk2_Ddis ------------------------------------------------------------
5306_Tthe ------------------------------------------------------------
5356_Tthe ------------------------------------------------------------
5655_Tthe ------------------------------------------------------------
DYRK2_Spur ------------------------------------------------------------
DYRK4_Spur ------------------------------------------------------------
CC1G_13957_Ccin ------------------------------------------------------------
AqueK112_Aque ------------------------------------------------------------
AqueK113_Aque ------------------------------------------------------------
DYRK2_b_Smoe ------------------------------------------------------------
DYRK2_a_Smoe ------------------------------------------------------------
GK034_Glam ------------------------------------------------------------
GK033_Glam INLGDEDQAQFAASAGQVSIGNSVSMDSMIRTTNEFIKATSASGLSEQIESSAQSLQSTG
GK032_Glam ------------------------------------------------------------
smi35A_Dmel ------------------------------------------------------------
Dyrk3_Dmel ------------------------------------------------------------
DYRK4_Mmus ------------------------------------------------------------
DYRK3_Mmus ------------------------------------------------------------
DYRK2_Mmus ------------------------------------------------------------
mbk-2_Cele ------------------------------------------------------------
C36B7.2_Cele ------------------------------------------------------------
C36B7.1_Cele ------------------------------------------------------------
DYRK4_Hsap ------------------------------------------------------------
DYRK3_Hsap ------------------------------------------------------------
DYRK2_Hsap ------------------------------------------------------------
Dyrk2_Ddis ------------------------------------------------------------
5306_Tthe ------------------------------------------------------------
5356_Tthe ------------------------------------------------------------
5655_Tthe ------------------------------------------------------------
DYRK2_Spur ------------------------------------------------------------
DYRK4_Spur ------------------------------------------------------------
CC1G_13957_Ccin ------------------------------------------------------------
AqueK112_Aque ------------------------------------------------------------
AqueK113_Aque ------------------------------------------------------------
DYRK2_b_Smoe ------------------------------------------------------------
DYRK2_a_Smoe ------------------------------------------------------------
GK034_Glam ------------------------------------------------------------
GK033_Glam SLHRSDVHSSSVGALGHVGAHHIRPQSSKAVSSISSAMNMATSLYSQTQLSTGAPTQTAS
GK032_Glam ------------------------------------------------------------
smi35A_Dmel ------------------------------------------------------------
Dyrk3_Dmel ------------------------------------------------------------
DYRK4_Mmus ------------------------------------------------------------
DYRK3_Mmus ------------------------------------------------------------
DYRK2_Mmus ------------------------------------------------------------
mbk-2_Cele ------------------------------------------------------------
C36B7.2_Cele ------------------------------------------------------------
C36B7.1_Cele ------------------------------------------------------------
DYRK4_Hsap ------------------------------------------------------------
DYRK3_Hsap ------------------------------------------------------------
DYRK2_Hsap ------------------------------------------------------------
Dyrk2_Ddis ------------------------------------------------------------
5306_Tthe ------------------------------------------------------------
5356_Tthe ------------------------------------------------------------
5655_Tthe ------------------------------------------------------------
DYRK2_Spur ------------------------------------------------------------
DYRK4_Spur ------------------------------------------------------------
CC1G_13957_Ccin ------------------------------------------------------------
AqueK112_Aque ------------------------------------------------------------
AqueK113_Aque ------------------------------------------------------------
DYRK2_b_Smoe ------------------------------------------------------------
DYRK2_a_Smoe ------------------------------------------------------------
GK034_Glam ------------------------------------------------------------
GK033_Glam KNGSSDAPAVVYTPVPPMADDITKSCLRLEISVTSMDVAEAGGTAMSGKDEKVFQSSVPL
GK032_Glam ------------------------------------------------------------
smi35A_Dmel -------------------AP---------------------------------------
Dyrk3_Dmel -------------------VY---------------------------------------
DYRK4_Mmus -------------------VP---------------------------------------
DYRK3_Mmus -------------------VI---------------------------------------
DYRK2_Mmus -------------------MT---------------------------------------
mbk-2_Cele -------------------VI---------------------------------------
C36B7.2_Cele -------------------PE---------------------------------------
C36B7.1_Cele -------------------NH---------------------------------------
DYRK4_Hsap -------------------AP---------------------------------------
DYRK3_Hsap -------------------VI---------------------------------------
DYRK2_Hsap -------------------MT---------------------------------------
Dyrk2_Ddis -------------------N----------------------------------------
5306_Tthe ------------------------------------------------------------
5356_Tthe -------------------IQ---------------------------------------
5655_Tthe -------------------KT---------------------------------------
DYRK2_Spur -------------------VI---------------------------------------
DYRK4_Spur -------------------VQ---------------------------------------
CC1G_13957_Ccin -------------------TP---------------------------------------
AqueK112_Aque -------------------VP---------------------------------------
AqueK113_Aque -------------------VI---------------------------------------
DYRK2_b_Smoe -------------------VG---------------------------------------
DYRK2_a_Smoe -------------------VG---------------------------------------
GK034_Glam ------------------------------------------------------------
GK033_Glam LPVTAYCDINAVIDTAVSGLDASDAKNSAKDKYKTILQVIRGQLDQTSLMNTTACSKLPI
GK032_Glam -------------------YK---------------------------------------
smi35A_Dmel ------TANTTNLGYDDD----------NGNYK------------------IIEHDHIAF
Dyrk3_Dmel --------GPNNSEYDNE----------QGAYI------------------HVPHDHVAY
DYRK4_Mmus ------E-KFSKTSFDDE----------HGSYM------------------KVLHDHIAY
DYRK3_Mmus ------G-GPNNGGYDDA----------DGAYI------------------HVPRDHLAY
DYRK2_Mmus ------G-GPNNGGYDDD----------QGSYV------------------QVPHDHVAY
mbk-2_Cele ------G-GANNGGYDDE----------NGSYQ------------------LVVHDHIAY
C36B7.2_Cele -------NA-IEKDFFEM----------GSIYK------------------MKKDEHIGY
C36B7.1_Cele ----------ELGIFTLP----------NGSYC------------------FKEGDHISY
DYRK4_Hsap ------E-KFSKTSFDDE----------HGFYL------------------KVLHDHIAY
DYRK3_Hsap ------G-GPNNGGYDDA----------DGAYI------------------HVPRDHLAY
DYRK2_Hsap ------G-GPNNGGYDDD----------QGSYV------------------QVPHDHVAY
Dyrk2_Ddis ------SQLP-NNGYDND----------IGEYK------------------VVERDHIAY
5306_Tthe --------AQENGNNDDT----------KGDYQ------------------YNVNDHIAY
5356_Tthe ------QANSYNFGYDDENLQKYYLIIKRGDYL------------------YTLNDHIAY
5655_Tthe --------SQFNNGFDDS----------RGEYQ------------------LNLLDHIAY
DYRK2_Spur ------G-GASNCGYDDD----------QGSYI------------------HVQHDHVAY
DYRK4_Spur ------G-ASQNNGYDDE----------NGSYI------------------KVIHDHLAY
CC1G_13957_Ccin ------DITTNNYSYDDE----------RGDYQ------------------VVLGDHLAY
AqueK112_Aque ------G-GSQNCGYDDE----------NGSYI------------------KVLHDHISY
AqueK113_Aque ------G-APQNSGYDDD----------AGTYL------------------IVAHDHVSY
DYRK2_b_Smoe ------GQGRYNYGFDTE----------KGDYN------------------AIMQDHIAY
DYRK2_a_Smoe ------GQGRYNYGFDTE----------KGDYN------------------AIMQDHIAY
GK034_Glam ------NGA-INHGYDDS----------RGDYI------------------GVINDHIMY
GK033_Glam YYNPLHTGAIEVTTPDD------------ADVP------------------FIEGETILN
GK032_Glam ------G-ETRNSKLLD----------LVGFYNIPLYYGLYSEFKGLHEMRFKKGAVLAG
. :
smi35A_Dmel RYEILEVIGK-GSFGQVIRALDHKTNTHVAIKIIRNKKRFLNQAVVELNILDELREKDAD
Dyrk3_Dmel RYEMLKIIGK-GSFGQVIKAYDHKTHEHVALKIVRNEKRFHRQAQEEIRILHHLRRHDKY
DYRK4_Mmus RYEVLEMIGK-GSFGQVAKCLDHKNNELVALKIIRNKKRFHHQALVELKILEALRRKDKD
DYRK3_Mmus RYEVLKIIGK-GSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKT
DYRK2_Mmus RYEVLKVIGK-GSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKD
mbk-2_Cele RYEVLKVIGK-GSFGQVIKAFDHKYQQYVALKLVRNEKRFHRQADEEIRILDHLRRQDSD
C36B7.2_Cele RYTIDKVIGQ-GCYGVVGEATDGKTKQKVAIRMVS---KLAPRIYRETEMIMYISSIDPD
C36B7.1_Cele RYSIDEVLSS-GYYAQVFRCTDKKTDKKVCIKLKN---RNLSTTYEETIILLRIHQLNRQ
DYRK4_Hsap RYEVLETIGK-GSFGQVAKCLDHKNNELVALKIIRNKKRFHQQALMELKILEALRKKDKD
DYRK3_Hsap RYEVLKIIGK-GSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKT
DYRK2_Hsap RYEVLKVIGK-GSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKD
Dyrk2_Ddis RFEIVSILGQ-GSFCQVVKGYDYKTGEMVALKILRNQKRFHNQALTEIKILEYLKTNDPN
5306_Tthe RYEIKEFLGK-GSFGQVLKVFDHKRKEYAALKVIRNKQKFHEQALIELNILHYIKEKDYD
5356_Tthe RYELIEALGK-GSFGQVIKVFDHKRKEYSALKIIRNKKNFYNQAIVELNILKYIKDNDPQ
5655_Tthe RYELLECLGK-GSFGSVVKVFDHKRKEFLALKVIRNKKKFHNQALIELNILSYIKEQDKD
DYRK2_Spur RYEVLKILGK-GSFGQVVKVYDHKTNQHIAVKMVRNEKRFHRQAQEEIRILEHLRKQDKD
DYRK4_Spur RYEILEVIGK-GSFGQVVKAFDHKLGEMIAIKIIRNKKRFHHQALIEVKILDALRRKDRD
CC1G_13957_Ccin RYEVVDTLGK-GSFGQVLNCRDHCTGESVAVKIIRNKKRFHHQALVEIKILDNLRKWDAD
AqueK112_Aque RYEIREIIGK-GSFGQVVKVFDHKTNQHIALKIIRNKKRFHHQALVEVKILDSLRKRDRD
AqueK113_Aque RYEVLKVLGK-GSFGQVLKAYDHKMQTHIALKVVRNEKRFHRQAQEEVKILEHLRRQDKD
DYRK2_b_Smoe RYEILGKLGR-GSFGQVLKCTDHKYKVPRAIKIIRNKKQFTQQAFIEINLLEFLRNKAAE
DYRK2_a_Smoe RYEILGKLGR-GSFGQVLKCTDHKYKVPRAIKIIRNKKQFTQQAFIEINLLEFLRNKAAE
GK034_Glam RYELVSKLGS-GSFGKVYKALDHKEQQFVALKIIKNRKRFQRQGLVEVKILELLRDNDPN
GK033_Glam RYKLLKMVGS-ATFSNVFSCLDLKDNVTYCLKIIKQEKEFFDQAIDEVHLLELLKDIDPN
GK032_Glam RYEIYKTIFEDSAFSVTLKARDLKEGKDVCLKVVNNEKDTLDQCLNEIRLLTYINKHDPT
*: : : . : . * .::: * :: :
smi35A_Dmel G--SHNVIHMLDYTYFRKHLCITFELMSLNLYELIKK-N-----------NYNGFSMSLI
Dyrk3_Dmel N--TMNIIHMFDYFTFRNHTCITFELLSINLYELIKK-N-----------GFKGFSLQLV
DYRK4_Mmus N--NHNVVHMKDFFYFRNHLCITFELLGINLYELMKN-N-----------SFHGFNLSIV
DYRK3_Mmus G--SMNVIHMLESFTFRNHVCMAFELLSIDLYELIKK-N-----------KFQGFSVQLV
DYRK2_Mmus N--TMNVIHMLENFTFRNHICMTFELLSMNLYELIKK-N-----------KFQGFSLPLV
mbk-2_Cele G--THNIIHMLDYFNFRNHKCITFELLSINLYELIKR-N-----------KFQGFSLMLV
C36B7.2_Cele H--TFDCVRMLDYNVFRGFHYVVTDLFDTSVKKYIKE-H-----------HPNGIALENV
C36B7.1_Cele N--NSNCVRMLDYDHFRGHHFIVLENYQTDLASYLCGRS-----------KLTP---REY
DYRK4_Hsap N--TYNVVHMKDFFYFRNHFCITFELLGINLYELMKN-N-----------NFQGFSLSIV
DYRK3_Hsap G--SMNVIHMLESFTFRNHVCMAFELLSIDLYELIKK-N-----------KFQGFSVQLV
DYRK2_Hsap N--TMNVIHMLENFTFRNHICMTFELLSMNLYELIKK-N-----------KFQGFSLPLV
Dyrk2_Ddis S--TASIVHLNNYFYFRNHLILTFELLSMNLYDFLKV-N-----------HFQGYNLNLV
5306_Tthe N--QTNIVKIRDFVIFRNHVCLVFELLSINLYDLLRN-N-----------KFQGLSLELI
5356_Tthe N--QTNIVKIKDFVIFRSHVGLL-------------------------------------
5655_Tthe E--ATNIVRIKDFVIFRKHV----------------------------------------
DYRK2_Spur N--NMNLIHMFESFSFRNHICITFELLSMNLYELIKK-N-----------KFQGFSLQLV
DYRK4_Spur N--SHNVVHMREYFYYRNHLCITFELLGMNLYELIKK-N-----------NFQGFSVALI
CC1G_13957_Ccin E--KHHVLKMTEHFYFRNHLCIATELLSINLYELIKA-N-----------GFVGFTTALI
AqueK112_Aque N--QYNIIHMFDYFYFRNHLCITFELMGMNLYELIKK-N-----------NFQGFSISLI
AqueK113_Aque N--AHNIIHMIDHFTFRNHVCITFELLSMNLYELIKK-N-----------KFQGFSLALV
DYRK2_b_Smoe EGVDYNIVTIYESFEFRGHLCLSFAVHDISLFDMLKK-N-----------HFEGFNLSLV
DYRK2_a_Smoe EGVDYNIVTIYESFEFRGHLCLSFAVHDISLFDMLKK-N-----------HFEGFNLSLV
GK034_Glam G--DQCCVKVLSSFYFRSHLCIAFELLSINLYELLTK-K-----------DLKGLSLSLV
GK033_Glam N--NINIIKIHDYFYFREHLLLKFTLLGEDLYTHFNR-REK-------KGQPNDYTIPVI
GK032_Glam G--K-HFVRMTDYFYYGHRLIIIFELLTSNLFSYYSA-REAALPRTLLNPLATIFTMPRL
: : . :
smi35A_Dmel RRFCNSIVKCLRLLYKENIIHCDLKPENILLKQR------GSSSIKVIDFGSSCYVDRK-
Dyrk3_Dmel RKFAHSLLQCLDALYKNDIIHCDMKPENVLLKQQ------GRSGIKVIDFGSSCFENQR-
DYRK4_Mmus RRFTFSILKCLHMLYVEKIIHCDLKPENIVLYQR------GQVTVKVIDFGSSCYEHQK-
DYRK3_Mmus RKFAQSILQSLDALHKNKIIHCDLKPENILLKHH------GRSATKVIDFGSSCFEYQK-
DYRK2_Mmus RKFAHSILQCLDALHKNRIIHCDLKPENILLKQQ------GRSSIKVIDFGSSCYEHQR-
mbk-2_Cele RKFAYSMLLCLDLLQKNRLIHCDLKPENVLLKQQ------GRSGIKVIDFGSSCFDDQR-
C36B7.2_Cele AAMGRKILKGLVFLHEHNIVHGDLKPENIMLNLA------NPNDVKLGDFGLSRFAKPYH
C36B7.1_Cele IPMIKSIVHGLKFLHQNKIIHGDLKPANVLLNEW------NRNNLKLTDFGLSTFVNQGP
DYRK4_Hsap RRFTLSVLKCLQMLSVEKIIHCDLKPENIVLYQK------GQASVKVIDFGSSCYEHQK-
DYRK3_Hsap RKFAQSILQSLDALHKNKIIHCDLKPENILLKHH------GRSSTKVIDFGSSCFEYQK-
DYRK2_Hsap RKFAHSILQCLDALHKNRIIHCDLKPENILLKQQ------GRSGIKVIDFGSSCYEHQR-
Dyrk2_Ddis RRFGAQILTSLRFLSKRNIIHADLKPENILLKSP------TKSGIKLIDFGSSCFENEQ-
5306_Tthe RRFAIQLLNAISFLKENRIIHCDLKPENVLLKQP------NKSGIKIADFGSSCFDDQV-
5356_Tthe ------------FLTKANIIHCDLKPENILLKQE------NKSGIKIVDFGSSCFENQR-
5655_Tthe ------ILNSINFLRKNRIIHCDLKPENILLKQA------NKSGVKLIDFGSSCFENER-
DYRK2_Spur RKFAHSLLQCLEGLHRNKIIHCDLKPENILLKQQ------GRSGIKVIDFGSSCYEHQR-
DYRK4_Spur RRFAFSLLQCLRMLHKERIIHCDLKPENILLRQK------GQSTIKVIDFGSSCYEHQR-
CC1G_13957_Ccin RRFTTQMLMSLSLMRHHRIVHCDLKPENVLLRHP------AKSAIKVIDFGSSCLEHEK-
AqueK112_Aque RRFAYSMLQCLKILYRERIIHCDLKPENILLRLR------GQSSIKVIDFGSSCYEHQR-
AqueK113_Aque RKFAHSILQCLDSLYRNRIIHCDLKPENILLKQP------GRSGIKVIDFGSSCYEYQR-
DYRK2_b_Smoe KCFARQVLVSLQFLHRARIIHGDLKPENILLQQP------ASPKIKLIDFGSSCFEHER-
DYRK2_a_Smoe KCFARQVLVSLQFLHRARIIHGDLKPENILLQQP------ASPKIKLIDFGSSCFEHER-
GK034_Glam RKFSLQLLIAFAYARKLRIIHADVKPENILLREP------DKSSIKVIDWGSGAMVSET-
GK033_Glam RDMARQVLKALDYIHRLGITHLDLKPENLLHGDKNFIGGVNEPSVTLVDFGSSSFIFDK-
GK032_Glam QHIARQILESLDFLHRLNILHLDLKHENLLLVNED----DDSFDIRLVDIGSSAFLYDE-
: * *:* *:: : * * .
smi35A_Dmel IYTYIQSRFYRSPEVILGLQYGTAIDMWSLGCILAELYTGFPLFPGENEVE--------Q
Dyrk3_Dmel IYTYIQSRFYRAPEVILGGKYGRAIDMWSLGCILAELLSGHALFPGENESD--------Q
DYRK4_Mmus VYTYIQSRFYRSPEVILGHPYNMAIDMWSLGCIMAELYTGYPLFPGENEVE--------Q
DYRK3_Mmus LYTYIQSRFYRAPEIILGCRYSTPIDIWSFGCILAELLTGQPLFPGEDEGD--------Q
DYRK2_Mmus VYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGD--------Q
mbk-2_Cele IYTYIQSRFYRAPEVILGTKYGMPIDMWSLGCILAELLTGYPLLPGEDEND--------Q
C36B7.2_Cele DHVQCQSMFYRAPEAFVRGRYNGATDMWSFGCTVAEMVSGKIFLAGDNCDD--------Q
C36B7.1_Cele FFRDYQTLYYKAPEVFCQGKVSVEIDIWSLGCVAAEIVRGTPLFVGDNYFD--------Q
DYRK4_Hsap VYTYIQSRFYRSPEVILGHPYDVAIDMWSLGCITAELYTGYPLFPGENEVE--------Q
DYRK3_Hsap LYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGD--------Q
DYRK2_Hsap VYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGD--------Q
Dyrk2_Ddis IFTYIQSRFYRSPEVILGTKYDKSIDIWSLGCILVEIFTGVPLFPGSDEPE--------Q
5306_Tthe MYTYIQSRYYRSPEVILGIPYGTEIDMWSFGCIIAELFLGYPIFPGEDENE--------Q
5356_Tthe VYTYIQSRFYRAPEIILGLPYGKAIDMWSFGCIMAELYIGYPLFPGENEAE--------Q
5655_Tthe LYTYIQSRYYRAPEVILGLPYDTSIDMWSFGCIMAELFIGYPIFPGEDEQE--------Q
DYRK2_Spur IYTYIQSRFYRAPEVILGGKYGMPIDMWSLGCILAELLTGYPLLPGEDEGD--------Q
DYRK4_Spur VYTYIQSRFYRSPEVILGLPYGLPIDMWSFGCILAELYTGYPLFPGENEVE--------Q
CC1G_13957_Ccin ----------------------------------TELYTGFPIFPGENEQE--------Q
AqueK112_Aque VYTYIQSRFYRSPEVILGLPYSMAIDMWSLGCILAELYTGYPLFPGENEVE--------Q
AqueK113_Aque VYTYIQSRFYRAPEVILGGKYGMSIDMWSFGCILAELLTGYPLFPGEDEGD--------Q
DYRK2_b_Smoe IYTYIQSRFYRAPEVILGLPYDMMIDVWSFACILAELFTGYPLFPGEDEVE--------Q
DYRK2_a_Smoe IYTYIQSRFYRAPEVILGLPYDMMIDVWSFACILAELFTGYPLFPGEDEVE--------Q
GK034_Glam IYSYIQSRFYRAPEVILGLPYGQEIDIWSIGCVLCELYTGLPIFPGDDERD--------Q
GK033_Glam MHSYIQSRSYRAPEVILATPYDSRADIWSFGCVVCELLTGRVLFPNYSVAT--------I
GK032_Glam CSTYVQSRSYRCPEVILGLPYDGRADVWSLGPILTELITGKVMFPIPQKADEDHKPYASM
*: * :: .
smi35A_Dmel LACIMEVLGLPPKVLISVARRRRLFFDS-RDAPRCITN----------------------
Dyrk3_Dmel LACIIEVLGMPNKNILASSKRSKSFFSP-KGYPRYCTV---RT-----------------
DYRK4_Mmus LACIMEVLGLPPAHFTQTASRRQVFFDS-KGLPKNINN----------------------
DYRK3_Mmus LACMIELLGMPPQKLLEQSKRAKYFINS-KGLPRYCSV---ST-----------------
DYRK2_Mmus LACMIELLGMPSQKLLDASKRAKNFVSS-KGYPRYCTV---TT-----------------
mbk-2_Cele LALIIELLGMPPPKSLETAKRARTFITS-KGYPRYCTA---TS-----------------
C36B7.2_Cele FYLMQEVINIPPPVFFDTFYTNYYFFSTLKEAPKHIVI---TDHG---------------
C36B7.1_Cele FALIQEFFGKPSRKLFNTWGGIHQFYTE-YFFPRHCFEWLNPFNG---------------
DYRK4_Hsap LACIMEVLGLPPAGFIQTASRRQTFFDS-KGFPKNITN----------------------
DYRK3_Hsap LACMMELLGMPPPKLLEQSKRAKYFINS-KGIPRYCSV---TT-----------------
DYRK2_Hsap LACMIELLGMPSQKLLDASKRAKNFVSS-KGYPRYCTV---TT-----------------
Dyrk2_Ddis LACIMEVLGAPPKSVIDNSTRKDIFFED-DGTPKPVKN---STTG---------------
5306_Tthe MGYIMELLGAPDSEFLKKCSRKKYFFDQ-NDQPLQIPN----------------------
5356_Tthe FQMFMEILGIPEEEFVENCPRRNVFFEN-NKTPKVVKN----------------------
5655_Tthe IGYIWEIIGAPSKDFLQNCTRRKYFFNE-DYTPKLIPN----------------------
DYRK2_Spur LACMIEVMGMPSQNLIDTSKRSKNFINS-KGQPRYCTV---TT-----------------
DYRK4_Spur LACIMEIFGLPPPHIIEEAQRRRLFFED-SSAPDVSKK----------------------
CC1G_13957_Ccin LSCIMEVLGVPDKEYINRSSRKKLFFDT-NGAPRPVVN---S-KG---------------
AqueK112_Aque LACIIEIFGLPDPALLAEAQRKKLFFDS-RGNPRCVTN----------------------
AqueK113_Aque LACMMEVLGLPSQKMIESTKRGRTFFSS-KGHPRYTTV---NI-----------------
DYRK2_b_Smoe LAYMMEVLGTPPLSLISQAKRKKMFFDS-DNKPRIVPN----------------------
DYRK2_a_Smoe LAYMMEVLGTPPLSLISQAKRKKMFFDS-DNKPRIVPN----------------------
GK034_Glam LGKICELLGMPPNDMIFKSPRKNDFFVN-IGTGMGVAG---VSEGGNPIFSGNLQQLSSV
GK033_Glam LSRICSLIGPIPRDMIMSGRMGQRVLTF-GLVPYEH------------------------
GK032_Glam LAKLIGIIGPIPRDMILAGRESHKLFTK-DLFL-F-------------------------
: : .:. .
smi35A_Dmel ---------------------TKGRKR-S-----------PGSKS------L--------
Dyrk3_Dmel --------MSDGMVVLIGGQSRRGKQRGP-----------PCSKS------L--------
DYRK4_Mmus ---------------------NRGGKR-Y-----------PDSKD------L--------
DYRK3_Mmus --------QTDGRVVLLGGRSRRGKKRGP-----------PGSKD------W--------
DYRK2_Mmus --------LSDGSVVLNGGRSRRGKLRGP-----------PESRE------W--------
mbk-2_Cele --------MPDGSVVLAGARSKRGKMRGP-----------PASRS------W--------
C36B7.2_Cele ----------P---IVSFIYTKAADHRKI-----------PGATP------I--------
C36B7.1_Cele ----------DRTMEIEPHYKLAHPSRKP-----------PLTSS------L--------
DYRK4_Hsap ---------------------NRGKKR-Y-----------PDSKD------L--------
DYRK3_Hsap --------QADGRVVLVGGRSRRGKKRGP-----------PGSKD------W--------
DYRK2_Hsap --------LSDGSVVLNGGRSRRGKLRGP-----------PESRE------W--------
Dyrk2_Ddis ------------------------ELY-T-----------IGTKS------F--------
5306_Tthe ---------------------SRGKIR-M-----------PNSKN------W--------
5356_Tthe ---------------------SRGKIR-T-----------PATKH------I--------
5655_Tthe ---------------------SKGKIR-V-----------PNSKI------L--------
DYRK2_Spur --------LPDGTTVLNGGRSRRGKVRGP-----------PGSKD------L--------
DYRK4_Spur ----------------------NGLRI-S-----------REKSN------L--------
CC1G_13957_Ccin ------------------------RRR-R-----------PGSKT------L--------
AqueK112_Aque ---------------------SKGKKR-R-----------PGSKD------L--------
AqueK113_Aque --------NPDGTASYTGGRSRRGKFRGP-----------PGTKD------M--------
DYRK2_b_Smoe ---------------------SSGTRH-F-----------PSTKD------L--------
DYRK2_a_Smoe ---------------------SSGTRH-F-----------PSTKD------L--------
GK034_Glam NEYLQATGRGAGGSEVPGIRLR--TTH-K-----------VNSKT------L--------
GK033_Glam ------------------DEKNRQHFYFT-----------PQQGL------LEYWLFGER
GK032_Glam ----------ETREAILGNRDKAEGLRHAEIKGEDYVYVLPKKTTIKAMLGW--------
smi35A_Dmel AHIL-HCQDRYFIDFLQRCLEWDPAERMTPDEAAHHEFLQPSASSRHRS--CRMSSS-SS
Dyrk3_Dmel SKALDGCKDPLFLNFIRGCLEWDADKRLTPSEALKHPWLRRRLPRPPSS--SS--G--CG
DYRK4_Mmus TMVVK-TYDSSFLDFLRRCLVWEPSLRMTPEQALKHAWIHEPRKFKPRPKPQILRKP-GA
DYRK3_Mmus ATALKGCGDYLFIEFLKRCLQWDPSARLTPAQALRHPWISKSTPKPLTM--DKVP---GK
DYRK2_Mmus GNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLRRRLPKPPTG--EKTA---VK
mbk-2_Cele STALKNMGDELFVDFLKRCLDWDPETRMTPAQALKHKWLRRRLPNPPRD--GLE-S--MG
C36B7.2_Cele GSFFTKTEQKPFNNFILKVFKWMPASRITAKQALDHPFFYSLSACFNQQ-----------
C36B7.1_Cele VSKLPGGNQKFLARFLMRCFEWDPTERIKSSFILNHPFFHESI-----------------
DYRK4_Hsap TMVLK-TYDTSFLDFLRRCLVWEPSLRMTPDQALKHAWIHQSRNLKPQPRPQTLRKS-NS
DYRK3_Hsap GTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTT-IDKVS---GK
DYRK2_Hsap GNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLRRRLPKPPTG--EKTS---VK
Dyrk2_Ddis KDSIR-SGDEDFDNFILDCLKWEPSQRITAEQGLKHDWIIKVIAPT--------------
5306_Tthe KSVI-GCTDDNFIDFIKKCLVWEPSQRLTPRDALLHPWILDGLPEDIRV--QHIKF--LK
5356_Tthe NYYL-RCPDENFIDFVSKCFTWKNHERMSPAEALVHDWILEGLPEEIRA--QHLQQ--MQ
5655_Tthe KAVL-QTESEDFTDFLTKCFVWEPQKRLKPSDALMHPWILEGLPPEIRI--QHIKY--IQ
DYRK2_Spur VKALKGCDDPLFLDFLKRCLEWDPSSRMTPSQALRHSWLRRRLPKPPAD--GHAN---TT
DYRK4_Spur ----N-AK----SDFVMPPIHLGINADLTAEKPVN-----K---VKPLLA---EDKAPSI
CC1G_13957_Ccin AQVLR-CNDEEFIDFIAKCLVWDPERRMKPQAAMRHPFVTAGKRKAQQQAAARATP--SS
AqueK112_Aque SSAIK-TSDLLFLDFIRRCLVWSASERMKPEEALQHAWIQEGFHSRPRATPRALHISPSS
AqueK113_Aque SRALKGCDDPQFLDFLRHCLEWDPAIRMTPPQALRHPWLRRRLPRAPII--SDGQS--LS
DYRK2_b_Smoe RMVV-GCSDKSFVNFLSCCLKWDKEQRMTPQQLLKHEWITQVLLFPRES-FGLIGF----
DYRK2_a_Smoe RMVV-GCSDKSFVNFLSCCLKWDKEQRMTPQQLLKHEWITQVLLFPRES-FGLIGF----
GK034_Glam SGVLN-APD-DFISFISLFLQWDPQRRCTPEVAMSHPWIQEGIRQINERN---ARP--SS
GK033_Glam CANL-TDEEVLFSDFCRQALIVDPIKRPTAAMLLEHPFIKGA------------------
GK032_Glam DSHPE-YCDDLFLDFIETIMRIDPRKRPTAAEALEHPWLKH-------------------
* : ..
smi35A_Dmel S-SG--LNSVSQKSSCYSFSEISPGTNGPVVASITST--TAVH-----------------
Dyrk3_Dmel ------------------------------------------------------------
DYRK4_Mmus ---S--IS---------------------------SE--ISTEKAEEQQASKGKK-----
DYRK3_Mmus R-VV--------------------------------------------------------
DYRK2_Mmus R-VT--------------------------------------------------------
mbk-2_Cele G-LA--------------------------------------------------------
C36B7.2_Cele ------------------------------------------------------------
C36B7.1_Cele ------------------------------------------------------------
DYRK4_Hsap ---F--FP---------------------------SE--TRKDKVQGCHHS-SRK-----
DYRK3_Hsap R-VV--------------------------------------------------------
DYRK2_Hsap R-IT--------------------------------------------------------
Dyrk2_Ddis ------------------------------------------------------------
5306_Tthe D-KS--FET--A-----------------------SE--KEFHKQSCLQ-AQ--------
5356_Tthe Q-TSPEIDM-TK-----------------------SQ---SSNKANTIEDQP--------
5655_Tthe S-QV-EIDRLTQ-----------------------EQ--QQYDKQ---------------
DYRK2_Spur S-AK--------------------------------------------------------
DYRK4_Spur E-V---------------------------------------------------------
CC1G_13957_Ccin S-S---LS---------------------------SHRSKHIT-----------------
AqueK112_Aque S-AG--TP---------------------------SS--SSHYHSQTLPSHQQKPNGRHG
AqueK113_Aque QGIP--PHL--P-----------------------SA--AAVHL----------------
DYRK2_b_Smoe ------------------------------------------------------------
DYRK2_a_Smoe ------------------------------------------------------------
GK034_Glam T-A---VR---------------------------AVDA---------------------
GK033_Glam ------------------------------------------------------------
GK032_Glam ------------------------------------------------------------
smi35A_Dmel ------------------NA-A----IATTTK-----------S----------------
Dyrk3_Dmel ------------------------------------------------------------
DYRK4_Mmus DE--ATKETT---DKLKDEA-E----KHLENS--G--------KQQSSVEHTADT-----
DYRK3_Mmus ------------------NP-T----NAFQGL--G--------S----------------
DYRK2_Mmus ------------------ES-T----GAITSI-----------S----------------
mbk-2_Cele ------------------------------------------------------------
C36B7.2_Cele ------------------------------------------------------------
C36B7.1_Cele ------------------------------------------------------------
DYRK4_Hsap DE--ITKETT---EKTKDSP-T----KHVQHS--G--------DQQDCLQHGADT-----
DYRK3_Hsap ------------------NP-A----SAFQGL--G--------S----------------
DYRK2_Hsap ------------------ES-T----GAITSI-----------S----------------
Dyrk2_Ddis ------------------------------------------------------------
5306_Tthe ------------------YN-A----DAQSAA-MA--------L-----------AL---
5356_Tthe ------------------QN-N----ENTSGVGQG--------R----------NSFKKA
5655_Tthe ------------------NN-N----SMTSSM-PS--------T-----------NLPES
DYRK2_Spur ------------------NK-R----HGSSAV-----------S----------------
DYRK4_Spur -------------IE-VEDS-E----KFLENL--E--------L----------------
CC1G_13957_Ccin ------------------ETPKKSMIGAPTPL--TARTPRSSHT----------------
AqueK112_Aque SSQPPSDI-SPGSVSYTDSS-R----RRLHPV--G--------S----------------
AqueK113_Aque ------------------SS-S----GAATNK-----------Q----------------
DYRK2_b_Smoe ------------------------------------------------------------
DYRK2_a_Smoe ------------------------------------------------------------
GK034_Glam ------------------------------------------------------------
GK033_Glam ------------------------------------------------------------
GK032_Glam ------------------------------------------------------------
smi35A_Dmel ------------------------------------------------------------
Dyrk3_Dmel ------------------------------------------------------------
DYRK4_Mmus ------------------------------------------------------------
DYRK3_Mmus ------------------------------------------------------------
DYRK2_Mmus ------------------------------------------------------------
mbk-2_Cele ------------------------------------------------------------
C36B7.2_Cele ------------------------------------------------------------
C36B7.1_Cele ------------------------------------------------------------
DYRK4_Hsap ------------------------------------------------------------
DYRK3_Hsap ------------------------------------------------------------
DYRK2_Hsap ------------------------------------------------------------
Dyrk2_Ddis ------------------------------------------------------------
5306_Tthe ------------------------------------------------------------
5356_Tthe EMNNSSSFGPSVVSVNTGLQERNKNIINSQSHQIQDV----------KINPQSQASNPSS
5655_Tthe KNTETSTIQSSQIGIKENM-----------------LKSDLKEFNQFGIPQNLNVQSSKN
DYRK2_Spur ------------------------------------------------------------
DYRK4_Spur ------------------------------------------------------------
CC1G_13957_Ccin ------------------------------------------------------------
AqueK112_Aque ------------------------------------------------------------
AqueK113_Aque ------------------------------------------------------------
DYRK2_b_Smoe ------------------------------------------------------------
DYRK2_a_Smoe ------------------------------------------------------------
GK034_Glam ------------------------------------------------------------
GK033_Glam ------------------------------------------------------------
GK032_Glam ------------------------------------------------------------
smi35A_Dmel -----------------------------------------------------RQQPPS-
Dyrk3_Dmel ------------------------------------------------------------
DYRK4_Mmus -----------------------------------------------------IQLPHL-
DYRK3_Mmus ------------------------------------------------------KLPPV-
DYRK2_Mmus ------------------------------------------------------KLPPP-
mbk-2_Cele ------------------------------------------------------------
C36B7.2_Cele ------------------------------------------------------------
C36B7.1_Cele ------------------------------------------------------------
DYRK4_Hsap -----------------------------------------------------VQLPQL-
DYRK3_Hsap ------------------------------------------------------KLPPV-
DYRK2_Hsap ------------------------------------------------------KLPPP-
Dyrk2_Ddis ------------------------------------------------------------
5306_Tthe --------------------------------------------------------QK--
5356_Tthe SSCQNAINKYGQKQNNAKNYVFKNQNPLNSVTNNQPLSQSKIEQAENPSSNNLSQIPLNQ
5655_Tthe ASEKN---------------------------------------------KNNMYIPSP-
DYRK2_Spur ------------------------------------------------------KLPPT-
DYRK4_Spur ------------------------------------------------------DEKNV-
CC1G_13957_Ccin -----------------------------------------------------SGVPNT-
AqueK112_Aque -----------------------------------------------------DSQPKV-
AqueK113_Aque -----------------------------------------------------RQLPEA-
DYRK2_b_Smoe ------------------------------------------------------------
DYRK2_a_Smoe ------------------------------------------------------------
GK034_Glam ----------------------------------------------------------R-
GK033_Glam ------------------------------------------------------------
GK032_Glam ------------------------------------------------------------
smi35A_Dmel --QSHGHAQSNGHLPDIKLSASDKYNSMQKVAVRSKITSSVSDLESVQQYSLHRIYGGVG
Dyrk3_Dmel ------------------------------------------------------------
DYRK4_Mmus --TE--------------------------------------------------------
DYRK3_Mmus --VG--------------------------------------------------------
DYRK2_Mmus --SS--------------------------------------------------------
mbk-2_Cele ------------------------------------------------------------
C36B7.2_Cele ------------------------------------------------------------
C36B7.1_Cele ------------------------------------------------------------
DYRK4_Hsap --VD--------------------------------------------------------
DYRK3_Hsap --VG--------------------------------------------------------
DYRK2_Hsap --SS--------------------------------------------------------
Dyrk2_Ddis ------------------------------------------------------------
5306_Tthe -IYK--------------------------------------------------------
5356_Tthe GISL--------------------------------------------------------
5655_Tthe -VNS--------------------------------------------------------
DYRK2_Spur ---G--------------------------------------------------------
DYRK4_Spur --ID--------------------------------------------------------
CC1G_13957_Ccin --PG--------------------------------------------------------
AqueK112_Aque --LE--------------------------------------------------------
AqueK113_Aque PISN--------------------------------------------------------
DYRK2_b_Smoe ------------------------------------------------------------
DYRK2_a_Smoe ------------------------------------------------------------
GK034_Glam --PD--------------------------------------------------------
GK033_Glam ------------------------------------------------------------
GK032_Glam ------------------------------------------------------------
smi35A_Dmel SGSTHHVSSAATRKHLPGTGSGI--------VGAMSSKYGSSTLAHNHHNVTHHNASTAT
Dyrk3_Dmel ---------------------------------GV-------------------------
DYRK4_Mmus ----------------------A--------SGKSETV----------------------
DYRK3_Mmus ----------------------I--------ASKLKAN----------------------
DYRK2_Mmus ----------------------S--------ASKLRTN----------------------
mbk-2_Cele --------------------------------DHEK------------------------
C36B7.2_Cele ------------------------------------------------------------
C36B7.1_Cele ------------------------------------------------------------
DYRK4_Hsap ----------------------A--------PKKSEAA----------------------
DYRK3_Hsap ----------------------I--------ANKLKAN----------------------
DYRK2_Hsap ----------------------S--------ASKLRTN----------------------
Dyrk2_Ddis ------------------------------------------------------------
5306_Tthe ----------------------Y--------NNKKRIL----------------------
5356_Tthe ----------------------Q--------NNKKKTD----------------------
5655_Tthe ----------------------S--------ANQQKIQ----------------------
DYRK2_Spur ----------------------A--------AGKD-------------------------
DYRK4_Spur ----------------------S--------QE---------------------------
CC1G_13957_Ccin ----------------------S--------SSHT-SS----------------------
AqueK112_Aque ----------------------P--------ATRRN-G---------------------Y
AqueK113_Aque ----------------------NATTAAPMTNGKLSNS----------------------
DYRK2_b_Smoe ------------------------------------------------------------
DYRK2_a_Smoe ------------------------------------------------------------
GK034_Glam ----------------------S--------RRV--------------------------
GK033_Glam ------------------------------------------------------------
GK032_Glam ------------------------------------------------------------
smi35A_Dmel ------------------------IATTTHHHHHHGGQQQQQSSSGASTMAMSH------
Dyrk3_Dmel --------------------------------------------------S-GL------
DYRK4_Mmus ------------------------AGSE---------------------MS-AE------
DYRK3_Mmus ------------------------L----------------------------M------
DYRK2_Mmus ------------------------L----------------------AQ----M------
mbk-2_Cele -----------------------------------------------KT-E-TL------
C36B7.2_Cele -----------------------------------------------------M------
C36B7.1_Cele ------------------------------------------------------------
DYRK4_Hsap ------------------------VGAEV------------------SMTS-PG------
DYRK3_Hsap ------------------------L----------------------------M------
DYRK2_Hsap ------------------------L----------------------AQ----M------
Dyrk2_Ddis ------------------------------------------------------------
5306_Tthe ------------------------E----------------------K-----K------
5356_Tthe ------------------------M----------------------I-----HLSDFNP
5655_Tthe ------------------------I----------------------K-----A------
DYRK2_Spur ------------------------------------------------------------
DYRK4_Spur --------------------------------------------------K---------
CC1G_13957_Ccin ------------------------FGS---------------------STR-SY------
AqueK112_Aque NKRNSLVIDSTGSVMRGGGAFPIATAGE---------------------TE---------
AqueK113_Aque ------------------------H----------------------SS-Q-TL------
DYRK2_b_Smoe ------------------------------------------------------------
DYRK2_a_Smoe ------------------------------------------------------------
GK034_Glam ------------------------------------------------------------
GK033_Glam ------------------------------------------------------------
GK032_Glam ------------------------------------------------------------
smi35A_Dmel -------------S-------------------------------------QS-------
Dyrk3_Dmel -------------C----------------------------------------------
DYRK4_Mmus -------------Q-------------------------------------QS-------
DYRK3_Mmus -------------S-------------------------------------ET-------
DYRK2_Mmus -------------T-------------------------------------DA-------
mbk-2_Cele -------------P----------------------------------------------
C36B7.2_Cele -------------S-------------------------------------LA-------
C36B7.1_Cele ------------------------------------------------------------
DYRK4_Hsap -------------Q-------------------------------------SK-------
DYRK3_Hsap -------------S-------------------------------------ET-------
DYRK2_Hsap -------------T-------------------------------------DA-------
Dyrk2_Ddis ------------------------------------------------------------
5306_Tthe -------------S-------------------------------------TT-------
5356_Tthe YESDQFSNTFSAATTTNAKKTQQQFGFVQNNTPQHQNLNGIKANNFLQQGNSQNQSIYPN
5655_Tthe -------------E-------------------------------------STKHSYDPN
DYRK2_Spur ------------------------------------------------------------
DYRK4_Spur -------------Y-------------------------------------AK-------
CC1G_13957_Ccin -------------R-------------------------------------TS-------
AqueK112_Aque -------------H-------------------------------------ND-------
AqueK113_Aque -------------L-------------------------------------QS-------
DYRK2_b_Smoe ------------------------------------------------------------
DYRK2_a_Smoe ------------------------------------------------------------
GK034_Glam ------------------------------------------------------------
GK033_Glam ------------------------------------------------------------
GK032_Glam ------------------------------------------------------------
smi35A_Dmel -------------------------T-----GDVSDRAI-------F-GRA
Dyrk3_Dmel -------------------------------SSRNESPV-----TGK-LDL
DYRK4_Mmus -------------------------T-----SSPKSTNI------LP-PIV
DYRK3_Mmus -------------------------S-----GSIPLCSV-----LPK-LIS
DYRK2_Mmus -------------------------N-----GNIQQRTV-----LPK-LVS
mbk-2_Cele -------------------------------NIDSNANI-----LMR-KKF
C36B7.2_Cele -------------------------D-----G--PLFA-----PKVK-RAA
C36B7.1_Cele ------------------------------------------------NIQ
DYRK4_Hsap -------------------------N-----FSLKNTNV------LP-PIV
DYRK3_Hsap -------------------------N-----GSIPLCSV-----LPK-LIS
DYRK2_Hsap -------------------------N-----GNIQQRTV-----LPK-LVS
Dyrk2_Ddis --------------------------------------------APS-TPS
5306_Tthe -------------------------Q-----GTVSEET------RNS-VVN
5356_Tthe QIKIRRPDSSKKNKIEQN-FVANEDL-----QKNSNLQ------IQS-GEN
5655_Tthe ----------QGNNIEKQLYFISQKR-----KQHQNNQ------QNI-KID
DYRK2_Spur -------------------------R-----QDVSQRTV-----LPK-IVT
DYRK4_Spur -------------------------K-----EQKQSGQF------LP-PIV
CC1G_13957_Ccin -------------------------QGHSLSSSVHSSRVMNGYSSTA-STK
AqueK112_Aque -------------------------P-----SCRSPSTS------SP-PPQ
AqueK113_Aque -------------------------D-----QLSSNRTV-----LPKIIDR
DYRK2_b_Smoe -----------------------------------YRS------SLS-TRS
DYRK2_a_Smoe -----------------------------------YRS------SLS-TRS
GK034_Glam -------------------------------ASASQRPL---LPALS-PKK
GK033_Glam ----------------------------------------------D-LLL
GK032_Glam -------------------------------------------------VY