TXK_Hsap MI----------------------------------------LSSYNTIQSVFCCC-CCC
TEC_Hsap MN----------------------------------------FNT------ILEEILIKR
ITK_Hsap MN----------------------------------------NFI------LLEEQLIKK
ITK_Mmus MN----------------------------------------NFI------LLEEQLIKK
BTK_Mmus MA----------------------------------------A-V------ILESIFLKR
BMX_Mmus MDDNM------------------------------------ESKS------ILEELLLKK
BMX_Hsap MD----------------------------------------TKS------ILEELLLKR
BTK_Hsap MA----------------------------------------A-V------ILESIFLKR
Btk29A_Dmel MMGTKHRNSHVNGSIKSSSSLRSSSKSFQAKMDLMSER---LYDV------VKSGSMVKR
TEC_Mmus MN----------------------------------------FNT------ILEEILIKR
TXK_Mmus MI----------------------------------------LSSYSSFQSVLCCCCCRC
TEC_Spur MSTSGYSTG----------------------------SFSTGSFS------LDSDHGFRL
AqueK442_Aque KG----------------------------------------------------------
AqueK443_Aque ------------------------------------------------------------
AqueK444_Aque ------------------------------------------------------------
AqueK445_Aque ML----------------------------------------------------------
AqueK446_Aque ------------------------------------------------------------
AqueK447_Aque MLVMEY-------------------------------------------------LPLSL
AqueK448_Aque MMPVNHQSG--------------------------------ADVE------LKVDYMVKR
TXK_Hsap SV--QKRQM-----------R---------------------------------------
TEC_Hsap SQ--QKKKTSPLNYKERLFVL---------------------------------------
ITK_Hsap SQ--QKRRTSPSNFKVRFFVL---------------------------------------
ITK_Mmus SQ--QKRRTSPSNFKVRFFVL---------------------------------------
BTK_Mmus SQ--QKKKTSPLNFKKRLFLL---------------------------------------
BMX_Mmus SQ--QKKKMSPNNYKERLFVL---------------------------------------
BMX_Hsap SQ--QKKKMSPNNYKERLFVL---------------------------------------
BTK_Hsap SQ--QKKKTSPLNFKKRLFLL---------------------------------------
Btk29A_Dmel AQ--NKKRFTPVNYKHRWFEL---------------------------------------
TEC_Mmus SQ--QKKKTSPLNYKERLFVL---------------------------------------
TXK_Mmus SV--QKRQV-----------R---------------------------------------
TEC_Spur SP--RRSKNPSGKKREKLKVLFDSGTESSEEGSLGLKYGGERFQLPDPVTSVPESSTPDS
AqueK442_Aque ------------------------------------------------------------
AqueK443_Aque ------------------------------------------------------------
AqueK444_Aque ------------------------------------------------------------
AqueK445_Aque ------------------------------------------------------------
AqueK446_Aque ------------------------------------------------------------
AqueK447_Aque TQCLEREE-LSLQMKYSLLLD---------------------------------------
AqueK448_Aque SQ--GKSALGATNFKKRVFVL---------------------------------------
TXK_Hsap ------------------------------------------------------------
TEC_Hsap ------------------------------------------------------------
ITK_Hsap ------------------------------------------------------------
ITK_Mmus ------------------------------------------------------------
BTK_Mmus ------------------------------------------------------------
BMX_Mmus ------------------------------------------------------------
BMX_Hsap ------------------------------------------------------------
BTK_Hsap ------------------------------------------------------------
Btk29A_Dmel ------------------------------------------------------------
TEC_Mmus ------------------------------------------------------------
TXK_Mmus ------------------------------------------------------------
TEC_Spur SIPEGFDPSIEGPNEIYDIADHGSVKRNFNDLYGGIRRSTYDSIISDSGNQQEPRRGSYP
AqueK442_Aque ------------------------------------------------------------
AqueK443_Aque ------------------------------------------------------------
AqueK444_Aque ------------------------------------------------------------
AqueK445_Aque ------------------------------------------------------------
AqueK446_Aque ------------------------------------------------------------
AqueK447_Aque ------------------------------------------------------------
AqueK448_Aque ------------------------------------------------------------
TXK_Hsap ------------------------------------------------------------
TEC_Hsap ------------------------------------------------------------
ITK_Hsap ------------------------------------------------------------
ITK_Mmus ------------------------------------------------------------
BTK_Mmus ------------------------------------------------------------
BMX_Mmus ------------------------------------------------------------
BMX_Hsap ------------------------------------------------------------
BTK_Hsap ------------------------------------------------------------
Btk29A_Dmel ------------------------------------------------------------
TEC_Mmus ------------------------------------------------------------
TXK_Mmus ------------------------------------------------------------
TEC_Spur RIFISHRDIPEPDYDDLPRDIPEQDYDELPRNYIPERDYDDLSQDIHVTQSRFHHATISS
AqueK442_Aque ------------------------------------------------------------
AqueK443_Aque ------------------------------------------------------------
AqueK444_Aque ------------------------------------------------------------
AqueK445_Aque ------------------------------------------------------------
AqueK446_Aque ------------------------------------------------------------
AqueK447_Aque ------------------------------------------------------------
AqueK448_Aque ------------------------------------------------------------
TXK_Hsap -------------------------------TQISLSTDEEL--P-EK------------
TEC_Hsap -------------------------------TKSMLTYYEGR--A-EKKYRKGFIDVSKI
ITK_Hsap -------------------------------TKASLAYFEDR--HGKKRTLKGSIELSRI
ITK_Mmus -------------------------------TKASLAYFEDR--HGKKRTLKGSIELSRI
BTK_Mmus -------------------------------TVHKLSYYEYDFERGRRGSKKGSIDVEKI
BMX_Mmus -------------------------------TKTSLSYYEYD--KMKRGSRKGSIEIKKI
BMX_Hsap -------------------------------TKTNLSYYEYD--KMKRGSRKGSIEIKKI
BTK_Hsap -------------------------------TVHKLSYYEYDFERGRRGSKKGSIDVEKI
Btk29A_Dmel -------------------------------TKRTFSYFDVE--NVERRRERGRIHLKGV
TEC_Mmus -------------------------------TKSVLSYYEGR--A-EKKYRKGVIDISKI
TXK_Mmus -------------------------------TQISLSREEEL--S-EK------------
TEC_Spur VVSKPMDTIVAKKSEARSLPIQAFLNGHLFLDVSRLPHV-----RNKRGKEKNRIDLNQI
AqueK442_Aque ------------------------------------------------------------
AqueK443_Aque ------------------------------------------------------------
AqueK444_Aque ------------------------------------------------------------
AqueK445_Aque ------------------------------------------------------------
AqueK446_Aque ------------------------------------------------------------
AqueK447_Aque -------------------------------VAKGLCYLHGK--RPP---L---------
AqueK448_Aque -------------------------------TNNKLSYYDGN--LEKRGGLKGQVDLNSV
TXK_Hsap ------------------------------------------------------------
TEC_Hsap KCVEIV--KNDDGVIPC-QN---------------------KYPFQ------VVHD----
ITK_Hsap KCVEIV--KSDI-SIPC-HY---------------------KYPFQ------VVHD----
ITK_Mmus KCVEIV--KSDI-SIPC-HY---------------------KYPFQTLVYLQVVHD----
BTK_Mmus TCVETV--IPEK-NPPP-ERQIPRRGEESSEMEQISIIERFPYPFQ------VVYD----
BMX_Mmus RCVEKV--NLEE-QTPV-ER---------------------QYPFQ------IVYK----
BMX_Hsap RCVEKV--NLEE-QTPV-ER---------------------QYPFQ------IVYK----
BTK_Hsap TCVETV--VPEK-NPPP-ERQIPRRGEESSEMEQISIIERFPYPFQ------VVYD----
Btk29A_Dmel RLVEEATVSGEG-GDPFAPD---------------------GYPFQ------VGYCEISA
TEC_Mmus KCVEIV--KNDDGVIPC-QN---------------------KFPFQ------VVHD----
TXK_Mmus ------------------------------------------------------------
TEC_Spur KVVEPV--ADG-A-----------------------------------------------
AqueK442_Aque ------------------------------------------------------------
AqueK443_Aque ------------------------------------------------------------
AqueK444_Aque ------------------------------------------------------------
AqueK445_Aque ------------------------------------------------------------
AqueK446_Aque ------------------------------------------------------------
AqueK447_Aque ----------------------------------------------------VHR-----
AqueK448_Aque KVIEKV--SDSAF------D---------------------KPSFQ------VVH-----
TXK_Hsap -----------------------------------------YTQRRRPWLSQLSNKKQS-
TEC_Hsap --------------------------------ANTLYIFAPSPQSRDLWVKKLKEEIKN-
ITK_Hsap --------------------------------NYLLYVFAPDRESRQRWVLALKEETRN-
ITK_Mmus --------------------------------NYLLYVFAPDCESRQRWVLTLKEETRN-
BTK_Mmus --------------------------------EGPLYVFSPTEELRKRWIHQLKNVIRY-
BMX_Mmus --------------------------------DGLLYVYASNEESRCQWLKALQKEIRG-
BMX_Hsap --------------------------------DGLLYVYASNEESRSQWLKALQKEIRG-
BTK_Hsap --------------------------------EGPLYVFSPTEELRKRWIHQLKNVIRY-
Btk29A_Dmel SANSHQLENGNGGGSGVGIEGQQSGRAVP---QYTLYVIANSEKERSEWIRAIRQVCEDS
TEC_Mmus --------------------------------ANTLYIFAPSPQSRDRWVKKLKEEIKN-
TXK_Mmus -----------------------------------------HSQRQRPWFAKLMGKTQS-
TEC_Spur ------------------------------------------LENRQNGI-QVTYMVQA-
AqueK442_Aque ------------------------------------------------------------
AqueK443_Aque ------------------------------------------------------------
AqueK444_Aque ------------------------------------------------------------
AqueK445_Aque ------------------------------------------------------------
AqueK446_Aque ------------------------------------------------------------
AqueK447_Aque ----------------------------DLTANNVLLTSSYSAKLSDLGVSRLADTFKK-
AqueK448_Aque ----------------------------G---DLTLYVIADDEAQRHDWLELLRQYCRS-
TXK_Hsap NTG--------RV--------------------------------Q--------------
TEC_Hsap NNN--------IMIKYHPKFWTDGSYQCCRQTEKLAPGCEKYNLFE--------------
ITK_Hsap NNS--------LVPKYHPNFWMDGKWRCCSQLEKLATGCAQYDPTK--------------
ITK_Mmus NNS--------LVSKYHPNFWMDGRWRCCSQLEKPAVGCAPYDPSK--------------
BTK_Mmus NSD--------LVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGS-L-K----P---
BMX_Mmus NPH--------LLIKYHSGFFVDGKFLCCQQSCKAAPGCTLWEAYAD--L-H----I---
BMX_Hsap NPH--------LLVKYHSGFFVDGKFLCCQQSCKAAPGCTLWEAYAN--L-H----T---
BTK_Hsap NSD--------LVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGS-L-K----P---
Btk29A_Dmel NTP--------KSYRYHPGLWSGKKWSCCKGLSRTTFGCRAAAHWREANN-N----P---
TEC_Mmus NNN--------IMIKYHPKFWADGSYQCCRQTEKLAPGCEKYNLFE--------------
TXK_Mmus NRG--------GV--------------------------------Q--------------
TEC_Spur NSN--------LSDRYHYGIWT-TKWTCCQKDYKGAPGCQNTFRQQPQ-P-Q----H---
AqueK442_Aque ------------------------------------------------------------
AqueK443_Aque ------------------------------------------------------------
AqueK444_Aque ------------------------------------------------------------
AqueK445_Aque ------------------------------------------------------------
AqueK446_Aque ------------------------------------------------------------
AqueK447_Aque DHLTTAPGNASVMP----PEALEDNPVYDHKLDVFSYGCLLLHVLTGQ-LP--------K
AqueK448_Aque NGK--------LQDFYHPGLFVNSKWSCCDHKSKHSTGCSPAFIKDEHQFSQGAASFGSS
TXK_Hsap ---------PSKRKPL--------------------------------------------
TEC_Hsap ---------SSIRKALPPA-----------------------------------------
ITK_Hsap ---------NASKKPLPPT-----------------------------------------
ITK_Mmus ---------NASKKPLPPT-----------------------------------------
BTK_Mmus -----GSSHRKTKKPLPPT-----------------------------------------
BMX_Mmus -----AISDEKHRA--PTF-----------------------------------------
BMX_Hsap -----AVNEEKHRV--PTF-----------------------------------------
BTK_Hsap -----GSSHRKTKKPLPPT-----------------------------------------
Btk29A_Dmel -SNGSSPAQNSTRSISPNSSTTNSQFSLQHNSSGSLGGGVGGGLGGGGSLGLGGGGGGGG
TEC_Mmus ---------SSIRKTLPPA-----------------------------------------
TXK_Mmus ---------PSKRKPL--------------------------------------------
TEC_Spur -----QHTDNGIRPPVPPT-----------------------------------------
AqueK442_Aque ------------------------------------------------------------
AqueK443_Aque ------------------------------------------------------------
AqueK444_Aque ------------------------------------------------------------
AqueK445_Aque ------------------------------------------------------------
AqueK446_Aque ------------------------------------------------------------
AqueK447_Aque PTKEY-APEPGKKKSFKKV-----------------------------------------
AqueK448_Aque PTR---GSGNIQHKALPPI-----------------------------------------
TXK_Hsap ------------------------------------------------------------
TEC_Hsap --------PETK------------------------------------------------
ITK_Hsap --------PEDN------------------------------------------------
ITK_Mmus --------PEDN------------------------------------------------
BTK_Mmus --------PEED------------------------------------------------
BMX_Mmus --------PE--------------------------------------------------
BMX_Hsap --------PD--------------------------------------------------
BTK_Hsap --------PEED------------------------------------------------
Btk29A_Dmel SCTPTSLQPQSS------------------------------------------------
TEC_Mmus --------PEIK------------------------------------------------
TXK_Mmus ------------------------------------------------------------
TEC_Spur --------PVPT------------------------------------------------
AqueK442_Aque ------------------------------------------------------------
AqueK443_Aque ------------------------------------------------------------
AqueK444_Aque ------------------------------------------------------------
AqueK445_Aque ------------------------------------------------------------
AqueK446_Aque ------------------------------------------------------------
AqueK447_Aque --------PEWERRSNYLK-----------------------------------------
AqueK448_Aque --------PPDAGG---FNGSGPGYGGQGYGGQGYGGQGYGGQGYGGQGYGGQGYGGGGH
TXK_Hsap ------------------------------------------------------------
TEC_Hsap ------------------------------------------------------------
ITK_Hsap ------------------------------------------------------------
ITK_Mmus ------------------------------------------------------------
BTK_Mmus ------------------------------------------------------------
BMX_Mmus ------------------------------------------------------------
BMX_Hsap ------------------------------------------------------------
BTK_Hsap ------------------------------------------------------------
Btk29A_Dmel --------------------------------------------------------LTTF
TEC_Mmus ------------------------------------------------------------
TXK_Mmus ------------------------------------------------------------
TEC_Spur -----------------------P--------------------------------N---
AqueK442_Aque ------------------------------------------------------------
AqueK443_Aque ------------------------------------------------------------
AqueK444_Aque ------------------------------------------------------------
AqueK445_Aque ------------------------------------------------------------
AqueK446_Aque ------------------------------------------------------------
AqueK447_Aque ---------------------------------------------------NLPKEN---
AqueK448_Aque NVHGPGPMASGPVYPASSGGGGGIYPHQPMAHANSGHVVVSNTHIQSGGHRTAPYQD---
TXK_Hsap ----------------------------PPLPPSEV--AEEK------------------
TEC_Hsap -----------------------KRRPPPPIPLEEE--DNSE------------------
ITK_Hsap -----------------------RRP-------LW---EPEE------------------
ITK_Mmus -----------------------RRS-------FQ---EPEE------------------
BTK_Mmus -----------------Q----ILKKPLPPEPTAAPISTTEL------------------
BMX_Mmus -----------------R----LLKIPR-AVPVLK-MDASSS------------------
BMX_Hsap -----------------R----VLKIPR-AVPVLK-MDAPSSSTTLAQYDNESKKNYGSQ
BTK_Hsap -----------------Q----ILKKPLPPEPAAAPVSTSEL------------------
Btk29A_Dmel KQSPTLLNGNGTLLDANM----PGGIPTPGTPNSKAKDNSHF------------------
TEC_Mmus -----------------------KRRPPPPIPPEE---ENTE------------------
TXK_Mmus ----------------------------PPLPQEPP---DER------------------
TEC_Spur -----------------P----TPRPPKPPIPNPPV-TDRPK------------------
AqueK442_Aque ------------------------------------------------------------
AqueK443_Aque ------------------------------------------------------------
AqueK444_Aque ------------------------------------------------------------
AqueK445_Aque ------------------------------------------------------------
AqueK446_Aque ------------------------------------------------------------
AqueK447_Aque -----------------ELLFLAK-RCLSDLPTGRPELVDSC------------------
AqueK448_Aque -----------------H----NL-APPPPVSKTRPSSTKPS------------------
TXK_Hsap ----I---QVKAL-----------------------------------------------
TEC_Hsap ----E---IVVAM-----------------------------------------------
ITK_Hsap ----T---VVIAL-----------------------------------------------
ITK_Mmus ----T---LVIAL-----------------------------------------------
BTK_Mmus ----K---KVVAL-----------------------------------------------
BMX_Mmus ----G---AILPQ-----------------------------------------------
BMX_Hsap PPSSS---TSLAQ-----------------------------------------------
BTK_Hsap ----K---KVVAL-----------------------------------------------
Btk29A_Dmel ---VK---LVVAL-----------------------------------------------
TEC_Mmus ----E---IVVAM-----------------------------------------------
TXK_Mmus ----I---QVKAL-----------------------------------------------
TEC_Spur ----M---IVIAK-----------------------------------------------
AqueK442_Aque ------------------------------------------------------------
AqueK443_Aque ------------------------------------------------------------
AqueK444_Aque ------------------------------------------------------------
AqueK445_Aque ------------------------------------------------------------
AqueK446_Aque ------------------------------------------------------------
AqueK447_Aque ----HFVEQVLSKYPKMQNVMQLLKEKEAAEKHLCELNAENEALRAEKVEIEKQLRADCE
AqueK448_Aque ----F---EVMAM-----------------------------------------------
TXK_Hsap -------------------YDFLPREPCNLALRRAEEYLILEKYNPHWWKAR--------
TEC_Hsap -------------------YDFQAAEGHDLRLERGQEYLILEKNDVHWWRAR--------
ITK_Hsap -------------------YDYQTNDPQELALRRNEEYCLLDSSEIHWWRVQ--------
ITK_Mmus -------------------YDYQTNDPQELALRCDEEYYLLDSSEIHWWRVQ--------
BTK_Mmus -------------------YDYMPMNANDLQLRKGEEYFILEESNLPWWRAR--------
BMX_Mmus -------------------YDSYSKKSCGSQPTSNIRYIPR-EDCPDWWQVR--------
BMX_Hsap -------------------YDSNSKKIYGSQPNFNMQYIPR-EDFPDWWQVR--------
BTK_Hsap -------------------YDYMPMNANDLQLRKGDEYFILEESNLPWWRAR--------
Btk29A_Dmel -------------------YPFKAIEGGDLSLEKNAEYEVIDDSQEHWWKVK--------
TEC_Mmus -------------------YDFQATEAHDLRLERGQEYIILEKNDLHWWRAR--------
TXK_Mmus -------------------YDFLPREPGNLALKRAEEYLILERCDPHWWKAR--------
TEC_Spur -------------------YDYDPLETIDIPLKRGKEYSVLNNSRDYWWKVR--------
AqueK442_Aque ------------------------------------------------------------
AqueK443_Aque ------------------------------------------------------------
AqueK444_Aque ------------------------------------------------------------
AqueK445_Aque ------------------------------------------------------------
AqueK446_Aque ------------------------------------------------------------
AqueK447_Aque RLTAKVAGLQNTLSSKENEFNYCTQVLKEIIRSRDEQLVKLQEDNVELLKKREADLKEEH
AqueK448_Aque -------------------YDYPGIEKGDLPLCKGQKVVIFDNSRDHWWRAR--------
TXK_Hsap ------------------------------------------------------------
TEC_Hsap ------------------------------------------------------------
ITK_Hsap ------------------------------------------------------------
ITK_Mmus ------------------------------------------------------------
BTK_Mmus ------------------------------------------------------------
BMX_Mmus ------------------------------------------------------------
BMX_Hsap ------------------------------------------------------------
BTK_Hsap ------------------------------------------------------------
Btk29A_Dmel ------------------------------------------------------------
TEC_Mmus ------------------------------------------------------------
TXK_Mmus ------------------------------------------------------------
TEC_Spur ------------------------------------------------------------
AqueK442_Aque ------------------------------------------------------------
AqueK443_Aque ------------------------------------------------------------
AqueK444_Aque ------------------------------------------------------------
AqueK445_Aque ------------------------------------------------------------
AqueK446_Aque ------------------------------------------------------------
AqueK447_Aque LTELAAMEEYEAKLLAATTEHKQQLCESHRESEVKVSEVLKEPVKSSQALKDTTAQQQST
AqueK448_Aque ------------------------------------------------------------
TXK_Hsap --DRLG---NEGLIPSNYV---------------------TENK--ITNLEIYEWYHRNI
TEC_Hsap --DKYG---NEGYIPSNYV---------------------TGKK--SNNLDQYEWYCRNM
ITK_Hsap --DRNG---HEGYVPSSYL---------------------VEKS--PNNLETYEWYNKSI
ITK_Mmus --DKNG---HEGYAPSSYL---------------------VEKS--PNNLETYEWYNKSI
BTK_Mmus --DKNG---QEGYIPSNYI---------------------TE-A--EDSIEMYEWYSKHM
BMX_Mmus --KLKS---EEDIACSNQLERNIASHSTSKMSWGFPESSSSE-E--EENLHAYDWFAGNI
BMX_Hsap --KLKSSSSSEDVASSNQKERNV-NHTTSKISWEFPESSSSE-E--EENLDDYDWFAGNI
BTK_Hsap --DKNG---QEGYIPSNYV---------------------TE-A--EDSIEMYEWYSKHM
Btk29A_Dmel --DALG---NVGYIPSNYV---------------------KPKA--LLGLERYEWYVGDM
TEC_Mmus --DKYG---SEGYIPSNYV---------------------TGKK--SNNLDQYGWYCRNT
TXK_Mmus --DRFG---NEGLIPSNYV---------------------TENR--LANLEIYEWYHKNI
TEC_Spur --DRHG---REGFIPSNYV---------------------EEKSKYSTGLERYDWFNGTW
AqueK442_Aque ------------------------------------------------------------
AqueK443_Aque ------------------------------------------------------------
AqueK444_Aque ------------------------------------------------------------
AqueK445_Aque ------------------------------------------------------------
AqueK446_Aque ------------------------------------------------------------
AqueK447_Aque PMAIDG---KEGLVASNIV---------------------K-----KVGLESEDWFFPTL
AqueK448_Aque --DDRG---NEGFVPSNYV---------------------K-----KVGLESEDWFFPTL
TXK_Hsap TRNQAEHLLRQESKEGAFIVRDSRHLGSYTISVFMGARR-STEAAIKHYQIKKN--DSGQ
TEC_Hsap NRSKAEQLLRSEDKEGGFMVRDSSQPGLYTVSLYTKFGG-EGSSGFRHYHIKETTTSPKK
ITK_Hsap SRDKAEKLLLDTGKEGAFMVRDSRTAGTYTVSVFTKAVVSENNPCIKHYHIKETNDNPKR
ITK_Mmus SRDKAEKLLLDTGKEGAFMVRDSRTPGTYTVSVFTKAII-SENPCIKHYHIKETNDSPKR
BTK_Mmus TRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTG-EPQGVIRHYVVCST--PQSQ
BMX_Mmus SRSQSEQLLRQKGKEGAFMVRNSSQMGMYTVSLFSKAVN-DKKGTVKHYHVHTN--AENK
BMX_Hsap SRSQSEQLLRQKGKEGAFMVRNSSQVGMYTVSLFSKAVN-DKKGTVKHYHVHTN--AENK
BTK_Hsap TRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTG-DPQGVIRHYVVCST--PQSQ
Btk29A_Dmel SRQRAESLLKQGDKEGCFVVRKSSTKGLYTLSLHTKV----PQSHVKHYHIKQN--ARCE
TEC_Mmus NRSKAEQLLRTEDKEGGFMVRDSSQPGLYTVSLYTKFGG-EGSSGFRHYHIKETATSPKK
TXK_Mmus TRNQTERLLRQEAKEGAFIVRDSRHLGSYTISVFTRARR-HTQSSIKHYQIKKN--DSGQ
TEC_Spur SRQRTELELKQESKEGCFTVRNSRTPGLCTLSVLAKEKGPSGEDVVRHYHIKQN--SIKE
AqueK442_Aque --------------------------------------------QAMHYLIRID--EEKK
AqueK443_Aque -----------------------------------------------HYHIKND--EEKK
AqueK444_Aque -----------------------------------------------HYHIKND--EEKK
AqueK445_Aque --------------------------------------------SVLQILM---------
AqueK446_Aque ------------------------------------------------------------
AqueK447_Aque SRVEAEAILKQENKDGTFVVRNSSQE-NYAISVFSQ------NGNVYHYPIKND--KEKK
AqueK448_Aque SRARAENILKQENKEGAFVVRNSSRDNMYTLSICH-------EGQVRHYHIKDD--EEKK
TXK_Hsap WYVAERHAFQSIPELIWYHQHNAAGLMTRLRYPVGLMGSCLPAT--AGFSYEKWEIDPSE
TEC_Hsap YYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPTT--AGFSYEKWEINPSE
ITK_Hsap YYVAEKYVFDSIPLLINYHQHNGGGLVTRLRYPVCFGRQKAPVT--AGLRYGKWVIDPSE
ITK_Mmus YYVAEKYVFDSIPLLIQYHQYNGGGLVTRLRYPVCSWRQKAPVT--AGLRYGKWVIQPSE
BTK_Mmus YYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSKQNKNAPST--AGLGYGSWEIDPKD
BMX_Mmus LYLAENYCFDSIPKLIHYHQHNSAGMITRLRHPVSTKANKVPVS--VALGSGIWELKREE
BMX_Hsap LYLAENYCFDSIPKLIHYHQHNSAGMITRLRHPVSTKANKVPDS--VSLGNGIWELKREE
BTK_Hsap YYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPST--AGLGYGSWEIDPKD
Btk29A_Dmel YYLSEKHCCETIPDLINYHRHNSGGLACRLKSSPC--DRPVPPT--AGLSHDKWEIHPME
TEC_Mmus YYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSTKGKNAPTT--AGFSYDKWEINPSE
TXK_Mmus WYITERHLFPSVPELIQYHQYNAAGLISRLRYPIGLLGSCLPAT--SGFSYEKWEIDPSE
TEC_Spur FYVAEKHCFRDMGKLVEYHQHNAGGLITRLRNPPGF---TLPTT--AGLGSTKWEINRSE
AqueK442_Aque YYIYNMHRFPTVTELIEYHKLNGGGLPTRLRQPPALLVPNQPALRVSSAFDDKWRIDKSE
AqueK443_Aque YFISERHRFPTIIELIDYHKLNGGGLATRLKRPPALLVPDQPVL--SSAFDDKWQIDKSE
AqueK444_Aque YFVSEKHRFPTITELIEYYKLNGGGLDTRLKRPPTLLAPDQPVL--SSAFDYKWQIDKSE
AqueK445_Aque ------------------------------------KTSDQ-----LFLSNDKWRIDKSE
AqueK446_Aque ------------------------------------------------------------
AqueK447_Aque YFVSEKHRFPTVIKLIEYYKLNGGGLVTRLKRLPALLVSNQPVL--SSAFDYKWQIDKTE
AqueK448_Aque YFISEKHRFPTITELIEYHKLNGGGLVTRLRRPPTQLVPNQPVL--SSAFDTKWQIDKSE
TXK_Hsap LAFIKEIGSGQFGVVHLGEWR-SHIQVAIKAINEGSMSEEDFIEEAKVMMKLSHSKLVQL
TEC_Hsap LTFMRELGSGLFGVVRLGKWR-AQYKVAIKAIREGAMCEEDFIEEAKVMMKLTHPKLVQL
ITK_Hsap LTFVQEIGSGQFGLVHLGYWL-NKDKVAIKTIREGAMSEEDFIEEAEVMMKLSHPKLVQL
ITK_Mmus LTFVQEIGSGQFGLVHLGYWL-NKDKVAIKTIQEGAMSEEDFIEEAEVMMKLSHPKLVQL
BTK_Mmus LTFLKELGTGQFGVVKYGKWR-GQYDVAIKMIREGSMSEDEFIEEAKVMMNLSHEKLVQL
BMX_Mmus ITLLKELGNGQFGVVQLGQWK-GQYDVAVKMIKEGAMSEDEFFQEAQTMMKLSHPKLVKF
BMX_Hsap ITLLKELGSGQFGVVQLGKWK-GQYDVAVKMIKEGSMSEDEFFQEAQTMMKLSHPKLVKF
BTK_Hsap LTFLKELGTGQFGVVKYGKWR-GQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQL
Btk29A_Dmel LMLMEELGSGQFGVVRRGKWR-GSIDTAVKMMKEGTMSEDDFIEEAKVMTKLQHPNLVQL
TEC_Mmus LTFMRELGSGLFGVVRLGKWR-AQYKVAIKAIREGAMCEEDFIEEAKVMMKLTHPKLVQL
TXK_Mmus LAFVKEIGSGQFGVVHLGEWR-AHIPVAIKAINEGSMSEEDFIEEAKVMMKLSHSRLVQL
TEC_Spur LKILQELGRGQFGIVHLAKLTHNNRFVAVKRMQEGSMSEEDFIDEAKVMKELQHENLVQL
AqueK442_Aque LSLGKELGSGQFKRVVAGQWR-NEVDVAIK-IMEGALNEDDLIKEAILMQKFQHDNLVKL
AqueK443_Aque LSLGDELSSGEFKRVVIGQWC-NKVDVAIKMIKEDAMNEDDFIEEAILMMKFQHDNLVKL
AqueK444_Aque LSFGKELGSGEFKRVVAGQWR-NKVDVAIKMIKEDVMNEDDFIEEAILMLKFQHDNLVKL
AqueK445_Aque LSLGKELGSGEFKKVVAGQWR-NEVDVAIK-IMEGALNEDDLIKEATLMEKFQHDNLVKL
AqueK446_Aque ------------------------------MIKEDAMNEDDFIEEAILMIKFQHDNLVKL
AqueK447_Aque LSFGKELGSGEFKRVVAGQWR-NKGDIAIKMIKEDTMNEEHLIEEAILMLKFQHDNLVKL
AqueK448_Aque LSLGKELGSGQFGRVVAGQWR-NKVDVAIKMMKEGAMNEDDFIEEAKVMQKFQHDNLVKL
: *. : *:.::.** * :: * .**::
TXK_Hsap YGVCIQRKPLYIVTEFMENGCLLNYLRENKGK-LR-KEMLLSVCQDICEGMEYLERNGYI
TEC_Hsap YGVCTQQKPIYIVTEFMERGCLLNFLRQRQGH-FS-RDVLLSMCQDVCEGMEYLERNSFI
ITK_Hsap YGVCLEQAPICLVFEFMEHGCLSDYLRTQRGL-FA-AETLLGMCLDVCEGMAYLEEACVI
ITK_Mmus YGVCLEQAPICLVFEFMEHGCLSDYLRSQRGL-FA-AETLLGMCLDVCEGMAYLEKACVI
BTK_Mmus YGVCTKQRPIFIITEYMANGCLLNYLREMRHR-FQ-TQQLLEMCKDVCEAMEYLESKQFL
BMX_Mmus YGVCSKKYPIYIVTEYITNGCLLNYLKSHGKG-LE-SCQLLEMCYDVCEGMAFLESHQFI
BMX_Hsap YGVCSKEYPIYIVTEYISNGCLLNYLRSHGKG-LE-PSQLLEMCYDVCEGMAFLESHQFI
BTK_Hsap YGVCTKQRPIFIITEYMANGCLLNYLREMRHR-FQ-TQQLLEMCKDVCEAMEYLESKQFL
Btk29A_Dmel YGVCSKHRPIYIVTEYMKHGSLLNYLRRHEKTLIGNMGLLLDMCIQVSKGMTYLERHNYI
TEC_Mmus YGVCTQQKPIYIVTEFMERGCLLNFLRQRQGH-FS-RDMLLSMCQDVCEGMEYLERNSFI
TXK_Mmus YGVCIQQKPLYIVTEFMENGCLLDYLRERKGQ-LQ-KALLLSMCQDICEGMAYLERSCYI
TEC_Spur YGVTSAQRPMCIVTEYMSKGCLLSYLRTHKFMLLENTAILIYMTQQVCFGMAYLESKGFI
AqueK442_Aque CGVCIRQRSVYIITELMVNGSLLQYLCNNQRL-VNKTDILLDMAIQICATMKFLEQSGFI
AqueK443_Aque YGVCIRQGPVYIITELMVNGSLLQYLRKNKHL-VDKTDIILDMALQICAAMKFFEQSGFI
AqueK444_Aque YGVCIRQGPVYIITELMANGCLLQYIRNNQHL-VKKTGIILDMAIQISDGMKFFEQSGLI
AqueK445_Aque YGVCIGQGPVYIITELNGNGSLLQYLCNNQHL-VNKTDILLDMAIQICAAMKFLEQSGFI
AqueK446_Aque YGVCIRQGPVYIITELMANGSLLQYLRNNQHL-VDNTDIILDMAIQICAAMKFFEQSGFI
AqueK447_Aque YGVCIGQGPVYIITELMANGCLLQYLRNNQHL-VKKTDIMLDMAIQICDAMKFFEQSGFI
AqueK448_Aque YGVCIKQGAVYIITELMVNGCLLQYLRNNKHL-VEKTDIILDMAIQICAAMKFLEQSGFI
** . .: :: * .*.* .:: . :: : ::. * ::* :
TXK_Hsap HRDL-----------------------------AARNCLVSSTCIVKISDFGMTRYVLDD
TEC_Hsap HRDL-----------------------------AARNCLVSEAGVVKVSDFGMARYVLDD
ITK_Hsap HRDL-----------------------------AARNCLVGENQVIKVSDFGMTRFVLDD
ITK_Mmus HRDL-----------------------------AARNCLVGENQVIKVSDFGMTRFVLDD
BTK_Mmus HRDL-----------------------------AARNCLVNDQGVVKVSDFGLSRYVLDD
BMX_Mmus HRDL-----------------------------AARNCLVDSDLSVKVSDFGMTRYVLDD
BMX_Hsap HRDL-----------------------------AARNCLVDRDLCVKVSDFGMTRYVLDD
BTK_Hsap HRDL-----------------------------AARNCLVNDQGVVKVSDFGLSRYVLDD
Btk29A_Dmel HRDL-----------------------------AARNCLVGSENVVKVADFGLARYVLDD
TEC_Mmus HRDL-----------------------------AARNCLVNEAGVVKVSDFGMARYVLDD
TXK_Mmus HRDL-----------------------------AARNCLVSSACVVKISDFGMARYVLDD
TEC_Spur HRDL-----------------------------AARNCLVGDKHIVKVADFGLTRYVMDD
AqueK442_Aque HRNL-----------------------------PARNCQVGYSNIVKVGGFSSARFVPDD
AqueK443_Aque HRNL-----------------------------AAINCLVGDRNIVKVGGFSSARFVPDD
AqueK444_Aque HRDLYMEQISNLKHKIKVTTKVAKKFQLVMINMAARNCLVGDRNIVKVGGFSLARFVPDD
AqueK445_Aque HRNL-----------------------------AARNCLVGDRNIVKVGSFSSARFVPDD
AqueK446_Aque HRNL-----------------------------AARNCLVGDRNIVKVAGFGSARYVPDN
AqueK447_Aque HRDL-----------------------------AARNCLVGYSNIVKVGGFSLARFVPDD
AqueK448_Aque HRDL-----------------------------AARNCLVGDRNIVKVGDFGLARFVTDD
**:* .* ** *. :*:..*. :*:* *:
TXK_Hsap EYVSSFGAKFPIKWSPPEVFLFNKYSSKSDVWSFGVLMWEVFT---EGKMPFENKSNLQV
TEC_Hsap QYTSSSGAKFPVKWCPPEVFNYSRFSSKSDVWSFGVLMWEVFT---EGRMPFEKYTNYEV
ITK_Hsap QYTSSTGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFS---EGKIPYENRSNSEV
ITK_Mmus QYTSSTGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFS---EGKIPYENRSNSEV
BTK_Mmus EYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYS---LGKMPYERFTNSET
BMX_Mmus QYVSSVGTKFPVKWSAPEVFHYFKYSSKSDVWAFGILMWEVFS---LGKQPYDLYDNSEV
BMX_Hsap QYVSSVGTKFPVKWSAPEVFHYFKYSSKSDVWAFGILMWEVFS---LGKQPYDLYDNSQV
BTK_Hsap EYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYS---LGKMPYERFTNSET
Btk29A_Dmel QYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFT---CGKMPYGRLKNTEV
TEC_Mmus QYTSSSGAKFPVKWCPPEVFNYSRFSSKSDVWSFGVLMWEIFT---EGRMPFEKNTNYEV
TXK_Mmus EYISSSGAKFPVKWCPPEVFHFNKYSSKSDVWSFGVLMWEVFT---EGKMPFENKSNLQV
TEC_Spur EYTSS-GTKFPIKWAPPEVLHYTRFSSKSDVWAFGILMWEVFS---GGLAPYPAMSNVEV
AqueK442_Aque EYEASVGVKYAVRWSPPEVITHARYSS---------------------------------
AqueK443_Aque EYTASEGAEFPARWSAPEVITHARYSSKSDIWSYGILLWELWT---GGKIPYPAFTTPEI
AqueK444_Aque EYTASVGAKYAVKWSPPEVITHARFSSKSDIWSYGILLWELWS---GGKTPYPAFTNPQA
AqueK445_Aque EYKASVGAKYAVRWSAPEVITHARFSSKSDIWSYD-LEWKIVGLRSQKETPFVVFGC---
AqueK446_Aque EYTASEGTEFAVKWIAPEVITHARYSSKSDVWSYGILLWELWT---GGKTPYPAFTNPQV
AqueK447_Aque QYTASEGAKYAVKWSPPEVITHGRFSSKSDVWSYGILLWELWS---SGKNPYLGISNPLV
AqueK448_Aque EYTASEGTKFPIKWAAPEVITHARFSSKSDVWSYGILLWELWS---GGKTPYPAFTNPQV
:* :* * ::. :* .***: . ::**
TXK_Hsap VEAISE-GFRLYRPHLAPMSIYEVMYSCWHEKP---------------------------
TEC_Hsap VTMVTR-GHRLYQPKLASNYVYEVMLRCWQEKP---------------------------
ITK_Hsap VEDIST-GFRLYKPRLASTHVYQIMNHCWKERP---------------------------
ITK_Mmus VEDIST-GFRLYKPRLASCHVYQIMNHCWKEKP---------------------------
BTK_Mmus AEHIAQ-GLRLYRPHLASERVYTIMYSCWHEKA---------------------------
BMX_Mmus VVKVSQ-GHRLYRPQLASDTIYQIMYSCWHELP---------------------------
BMX_Hsap VLKVSQ-GHRLYRPHLASDTIYQIMYSCWHELP---------------------------
BTK_Hsap AEHIAQ-GLRLYRPHLASEKVYTIMYSCWHEKA---------------------------
Btk29A_Dmel VERVQR-GIILEKPKSCAKEIYDVMKLCWSHGP---------------------------
TEC_Mmus VTMVTR-GHRLHRPKLASKYLYEVMLRCWQERP---------------------------
TXK_Mmus VEAISQ-GFRLYRPHLAPMTIYRVMYSCWHESP---------------------------
TEC_Spur VDQVTRHNYRMERPDHCPYQMYRIMKDCWRECA---------------------------
AqueK442_Aque ------------------------------------------------------------
AqueK443_Aque LDGVLK-GYRLEKPKLCPSNIYDLMTRSWEKNP---------------------------
AqueK444_Aque LDEVSK-GYRLEKPKLCPSKVYDLMKRSWQKGLCYLHGKHPPIVHRDLTANNVLLTSSYS
AqueK445_Aque ------------------------------------------------------------
AqueK446_Aque LDEVLR-GYRLEKPKLCPSKIYDLMKRSWQT-----------------------------
AqueK447_Aque LDKVLS-GYRLEKPKLCPSKVYDLMKRSWQVNP---------------------------
AqueK448_Aque LDEVLR-GYRLENPKLCPPEVYDLMKKSWQANP---------------------------
TXK_Hsap -----------------------------------EG----RPTFAELLR----------
TEC_Hsap -----------------------------------EG----RPSFEDLLR----------
ITK_Hsap -----------------------------------ED----RPAFSRLLR----------
ITK_Mmus -----------------------------------ED----RPPFSQLLS----------
BTK_Mmus -----------------------------------DE----RPSFKILLS----------
BMX_Mmus -----------------------------------EK----RPTFQQLLS----------
BMX_Hsap -----------------------------------EK----RPTFQQLLS----------
BTK_Hsap -----------------------------------DE----RPTFKILLS----------
Btk29A_Dmel -----------------------------------EE----RPAFRVLMD----------
TEC_Mmus -----------------------------------EG----RPSFEDLLR----------
TXK_Mmus -----------------------------------KG----RPTFAELLQ----------
TEC_Spur -----------------------------------KVYNSNGPSLQCPVA----------
AqueK442_Aque ------------------------------------------------------------
AqueK443_Aque -----------------------------------FK----RPSFAVLLD----------
AqueK444_Aque AKISDLGVSRLADMFKKHHLTTAPGNAMVMPPEALKD----NPVYDHKYLVDQKWLKKWK
AqueK445_Aque ------------------------------------------------------------
AqueK446_Aque ------------------------------------------------------------
AqueK447_Aque -----------------------------------SD----RPSFAVLLD----------
AqueK448_Aque -----------------------------------ED----RPSFAVLSD----------
TXK_Hsap ----------AVTEIAE-------------TW
TEC_Hsap ----------TIDELVECE--------ETFGR
ITK_Hsap ----------QLAEIAE------------SGL
ITK_Mmus ----------QLAEIAE------------AGL
BTK_Mmus ----------NILDVMD------------EES
BMX_Mmus ----------AIEPLREQ-----------DKP
BMX_Hsap ----------SIEPLREK-----------DKH
BTK_Hsap ----------NILDVMD------------EES
Btk29A_Dmel ----------QLALVAQT-----------LTD
TEC_Mmus ----------TIDELVECE--------ETFGR
TXK_Mmus ----------VLTEIAE-------------TW
TEC_Spur ----------SLM--WECDLSPVPSHFIAMEM
AqueK442_Aque -------------------------------K
AqueK443_Aque ----------YLKAMVG-------DDYSDAID
AqueK444_Aque KYTGFDSWDQATAEHAH--PGPIDTAILFKRM
AqueK445_Aque ---------------------------DKTYL
AqueK446_Aque -------------------------------V
AqueK447_Aque ----------SLKAMVG-------GDYSDPVD
AqueK448_Aque ----------SLKAMVG-------DDYSDAVD