PIM3_Hsap       YQVGAVLGSGGFGTVYAGSRIAD-GLPVAVKHVVKERVTEWGSL-GGATVPLEVVLLRKV
PIM2_Hsap       YRLGPLLGKGGFGTVFAGHRLTD-RLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKV
PIM1_Hsap       YQVGPLLGSGGFGSVYSGIRVSD-NLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKV
PIM3_Mmus       YQVGAVLGSGGFGTVYAGSRIAD-GLPVAVKHVVKERVTEWGSL-GGVAVPLEVVLLRKV
PIM2_Mmus       YRLGPLLGKGGFGTVFAGHRVTD-RRQVAIKVISRNRVLGWSTVSDSVTCPLEVALLWKV
PIM1_Mmus       YQVGPLLGSGGFGSVYSGIRVAD-NLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKV
prk-2_Cele      YKLKAELGRGGFGVVYRAVRTCD-NALVAVKFIERSNVKEWARI-NGEQVPMEICMLAKC
prk-1_Cele      YEVLDEIGRGGFGIVYEATTRQDGQQPVAVKFVQHKHVRSWTMT-CRQLIPSEVCHLETC
Pim_Spur        YSIGSLIGSGGFGTVYAGSRISD-NLPVAIKLVNKEKVNDWVQL-NGREVPLEVSLLKRV
                * :   :* **** *: .    *    **:* : :..:  *         * *:  *

PIM3_Hsap       GAAGGARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAA
PIM2_Hsap       GAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRCFFGQVVAA
PIM1_Hsap       SS--GFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEA
PIM3_Mmus       GAAGGARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAA
PIM2_Mmus       GEGNGHPGVIRLLDWFETPEGFMLVLERPMPAQDLFDYITEKGPLGESCSRSFFTQVVAA
PIM1_Mmus       SS--DFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEDLARGFFWQVLEA
prk-2_Cele      S---KVRGVIRLLDWYSIPEGFLIVMERPYPCIDMFDFIKGQGKISEDMARFLFRQIAVT
prk-1_Cele      E---DIPGVIKILDWFANSKGFLIVMERPANCMDLFDMVSVHGPLNEDMGKFIFKQVITT
Pim_Spur        SS---IHGCISMLDYFEQPDSFVIVMERPDPAKDLFDFITEQGPLPEELCRRFFKQMW--
                       * * :**::   ..*::::***    *:** :. :* : *   : :* *:

PIM3_Hsap       VRHCHS-CGVVHRDIKDENLLVDLRSGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWI
PIM2_Hsap       IQHCHS-RGVVHRDIKDENILIDLRRGCAKLIDFGSGALLHDEPYTDFDGTRVYSPPEWI
PIM1_Hsap       VRHCHN-CGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWI
PIM3_Mmus       VRHCHN-CGVVHRDIKDENLLVDLRSGELKLIDFGSGAVLKDTVYTDFDGTRVYSPPEWI
PIM2_Mmus       VQHCHA-RGVVHRDIKDENILIDLCRGSIKLIDFGSGALLHDEPYTDFDGTRVYSPPEWI
PIM1_Mmus       VRHCHN-CGVLHRDIKDENILIDLSRGEIKLIDFGSGALLKDTVYTDFDGTRVYSPPEWI
prk-2_Cele      VHECVQ-NRVLHRDLKDENIVIDLVTGSTKLIDFGAATVLRRSQYSDFQGTRLYCPPEWF
prk-1_Cele      VFNMYSKHGLLHRDIKDENLIVNMNTGEVKLVDFGATAYAEKATKKEFQGTRSYCPPEWF
Pim_Spur        --------------------------------KLQAAAMRLDTVYKDFDGTRVYSPPEWI
                                                .: : :       .:*:*** *.****:

PIM3_Hsap       RYHRYHGRSATVWSLGVLLYDMVCGDIPFEQDEEILRGR----LLFRRRVSPECQQLIRW
PIM2_Hsap       SRHQYHALPATVWSLGILLYDMVCGDIPFERDQEILEAE----LHFPAHVSPDCCALIRR
PIM1_Hsap       RYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQ----VFFRQRVSSECQHLIRW
PIM3_Mmus       RYHRYHGRSATVWSLGVLLYDMVCGDIPFEQDEEILRGR----LFFRRRVSPECQQLIEW
PIM2_Mmus       SRHQYHALPATVWSLGVLLYDMVCGDIPFERDQEILEAE----LHFPAHVSPDCCALIRR
PIM1_Mmus       RYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIKGQ----VFFRQTVSSECQHLIKW
prk-2_Cele      LHSLYLGREAAVWSLGVLLYNSLNGRLPFRNEKDICTAHLLGPLPFFVPVSAEVKDLISK
prk-1_Cele      RDQLYLPLEATSWSLGVLLFILLTGKLPFRNEIQICLGN----VKFPPDLSKEVCQLVKS
Pim_Spur        TSHRYHGRSATIWSLGILLFDMACGDIPFEKDDEICRAE----LYFRDGLSHSLKNLIQS
                    *    *: ****:**:    * :**..: :*  ..    : *   :* .   *:

PIM3_Hsap       CLSLRPSERPSLDQIAAHPWM
PIM2_Hsap       CLAPKPSSRPSLEEILLDPWM
PIM1_Hsap       CLALRPSDRPTFEEIQNHPWM
PIM3_Mmus       CLSLRPSERPSLDQIAAHPWM
PIM2_Mmus       CLAPKPCSRPSLEEILLDPWM
PIM1_Mmus       CLSLRPSDRPSFEEIRNHPWM
prk-2_Cele      CLTFDPFQRCSLEAILNHPWV
prk-1_Cele      CLTTSTSARASLAQIAAHPWM
Pim_Spur        MLQVKPQHRLKIEDILDHPWM
                 *   .  * .:  *  .**: