Gene PEK-S1_u (S.moellendorffii)

PEK-S1_u

Species: S.moellendorffii
Alias: PEK-S1_u
External Links:
Annotation:

Classification

Group: Other
Family: PEK
Subfamily: PEK-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
PEK-S1_u.AA Protein None 357 None Fasta, JSON
PEK-S1_u.NA RNA None 1074 None Fasta, JSON
PEK-S1_u.kin_dom Protein Kinase Domain None 251 None Fasta, JSON

Protein domain

Protein domains of PEK-S1_u.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Pkinase PEK-S1_u.AA Pkinase 103-251 30 5.8e-39 138.85 Pfam 1-160 (293) Show / Hide 
Range on Protein: 103-251
Range on HMM: 1-160/293
Sequence Identity: 30% (51 aa)

YEVLACVGQGASGKVYKCRSKEDEQIYAIKVIKVRTATKSRDQDVALVFKEGEMLQRCEHPNIVKYFDMWKEEGEPGKSKVYIVMEFCGR-----SLQ--
|... ..|.|..|.||||. | ...|.|.|.||.|.. .. ||  ..   | ....|. |||||...|.. .     |...|.|||.|.      .|   
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL-SEIQIMKRLNHPNIVRLYDWFED-----KDHIYMVMEYCEGGLYVMDLFDY

-----SVLL-GGESPPADAFRQLLQAVAHVHDNVGVHRDIAPHNIFVTDDGRI----KLGDFGLAK
     .  . . |    . ..|.|..... |..  .|||. | ||.. ..| |    |..||||||
ISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAK
S_TKc PEK-S1_u.AA S_TKc 103-353 24 1.1e-33 119.15 SMART 1-231 (231) Show / Hide 
Range on Protein: 103-353
Range on HMM: 1-231/231
Sequence Identity: 24% (68 aa)

YEVLACVGQGASGKVYKCRSKEDEQIYAIKVIKVRTATKSRDQDVALVFKEGEMLQRCEHPNIVKYFDMWKEEGEPGKSKVYIVMEFCGR---SLQSVLL
||.|  .|.|| ||||||| |.. .|.|||.||              . .| ..|..  ||||||..|.. .      ...|.|||.|.    .| ... 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------------EHIRREIQILKK-HHPNIVKLYDVFQD------DHLYMVMEYCDGDLGDLFDYIK

GGESPP---------ADAFRQLLQAVAHVHDNVGVHRDIAPHNIFVTDDGRIKLGDFGLAKNKESMLETENIKKGRAVYYSPQRRSNST-YTDMLALGVI
   ...         .  ..|...|... |..  .|||. | ||....  .||..|||||.         .   |   | .|   . ..   |. ..|.|
KRGRHGLRFPFPEHARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVLGYGKCKCDWWSCGCI

LFELHWRCPPDQERESVLIDVRDGVLPADWAYQHPSIAPK--VLELVAARRDQRPSARDILC-------DPAW
|.|.  ..|| .  . .....              |   |  .  .     ..||.| ..|        .|  
LYEMLCGYPPFP-QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase PEK-S1_u.AA CAMK 108-259 18 2.9e-33 104.01 In-house 1-278 (425) Show / Hide 
Range on Protein: 108-259
Range on HMM: 1-278/425
Sequence Identity: 18% (51 aa)

CVGQGASGKVYKCRSKEDE------------QIYAIKVIKVRTATKS-----------------------RDQDVALVFKEGEMLQRCE-------HPNI
  |.|. |||..|. |..             | .|||.|. . ....                       |..| . |..| |.....        ||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VKYFDMWKEEG------EPG---------KSKVYIVM---EFCGR-----SLQSVLLG----------------GESPPADA---FRQLLQAVAHVHDNV
.| ....  .       . .         ....|.||   |.|        | . .                  |  . ..|   |||...||.. |.. 
IKLYEVYEDPHYFKNTND-YETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

GVHRDIAPHNIFVTDD-----------------GRIKLGDFGLAKNKES--------------------------MLET
 ||||. | || ..|.                 . ||. |||.|. ...                          ...|
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKT
Kinase PEK-S1_u.AA CMGC 103-251 19 4e-32 102.13 In-house 1-252 (513) Show / Hide 
Range on Protein: 103-251
Range on HMM: 1-252/513
Sequence Identity: 19% (49 aa)

YEVLACVGQGASGKVYKCRS--------------KEDEQIYAIKVIKVRTATKSR-----DQDVAL--VFKEGEMLQRCE-----------------HPN
||..  .|.|. |.|||||               .|...|.||| || .   .         |.     . | ..|..                   |.|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IVKYFDMWKEEGEPGKS------------KVYIVMEFCGRSLQSVLLGGES--------PPADAF-----------------------RQLLQAVA--HV
||| .|. . ... |.             ..|.|.|... .|  ..             |  .                         .|.|....  . 
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HDNV--GVHRDIAPHNIFVTDD--------------------GRIKLGDFGLAK
| .    .|||. | || ....                    ||.|..|||||.
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLAR
Kinase PEK-S1_u.AA STE 103-252 24 4.9e-32 110.46 In-house 1-196 (359) Show / Hide 
Range on Protein: 103-252
Range on HMM: 1-196/359
Sequence Identity: 24% (49 aa)

YEVLACVGQGASGKVYKCRSKE---------------DEQIYAIKVIKVRTATKSRDQ-------------DVALVFKEGEMLQRCE--HPNIVKYFDMW
.| . ..|.||.|.|||.. ..                 .|.|||...... ...  .             ..  . || .....|   |||||||... 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKD-ENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCY

KEEGEP--GKSKVYIVMEFCG-RSLQSVLL---GG---------------ESPPADAFRQLLQA-VAHVHDNVGVHRDIAPHNIFVTDDGRIKLGDFGLA
  ||..   .....|.||...  || ...    |                ||  |   ||.|..  .. |..  .|||| | ||..     .|| |||..
FKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVC

KN
..
GQ
Kinase PEK-S1_u.AA WEE 103-252 25 7.3e-32 104.21 In-house 1-181 (297) Show / Hide 
Range on Protein: 103-252
Range on HMM: 1-181/297
Sequence Identity: 25% (48 aa)

YEVLACVGQGASGKVYKCRSKEDEQIYAIKVI-KVRTATKSRDQDVALVFKEGEMLQ---RCE-HPNIVKYFDMWKEEGEPGKSKVYIVMEFCGRS----
....  .|.| .|.|||||...| .|||||.. . .  ...|.. .  | .  . |     |. ||.||.|.  |.|     ... ||.||.| ..    
FQEVQKIGEGSFGEVYKCRCRIDGCIYAIKKSKQPFRGYSERKRALREV-YAHMVLGQIMDCDHHPHIVRYYSAWEE-----DDHMYIQMEYCNGGSNLL

--LQSVLLG-----GESPPADAFRQLLQAVAHVHDN-VGVHRDIAPHNIFVTDDG--------------------RIKLGDFGLAKN
  ...  .       |.   . .....|...|.|.|   || || | |||.. ..                    ..|.||||....
QFWIQQCHNWNHWLPEWMIWQILVDICQGLHHIHSNCGMVHMDIKPENIFISKKMNCNQIVNNDQQNNNDWWFNMMCKIGDFGHVTD
Kinase PEK-S1_u.AA CAMKL 103-259 25 7.7e-32 98.78 In-house 1-192 (297) Show / Hide 
Range on Protein: 103-259
Range on HMM: 1-192/297
Sequence Identity: 25% (50 aa)

YEVLACVGQGASGKVYKCRS-KEDEQIYAIKVIKVRTAT------------KSRDQDVALVFKEGEMLQRCE---HPNIVKYFDMWKEEGE--PGKSKVY
|...   |.|. |||  ..  .  .. .|||.|. . ..            |. ..|.  ...| . ...     ||||.| ....  .       .|.|
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKH-ESDM-RIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIET-KKIY

IVMEFCGRS---LQSVL--LGGES---PPADA---FRQLLQAVAHVHDNVGVHRDIAPHNIFVTDDG--RIKLGDFGLA-------KNKESMLET
.||| |.     |.  .   |.     |. .|   |||.. ||.. |..  ||||| | || ....|   ||. |||..       .... .|.|
LVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKT
Kinase PEK-S1_u.AA PEK 209-353 24 2.9e-28 95.0 In-house 433-655 (655) Show / Hide 
Range on Protein: 209-353
Range on HMM: 433-655/655
Sequence Identity: 24% (54 aa)

FRQLLQAVAHVHDNVGVHRDIAPHNIFVTDDGR-----IKLGDFGLAKNKE--------------SMLETENIKK-------------------------
|||.| .....| .  .|||. |.|||...||.     .| ||||||.| |              | .. .....                         
FRQILEGLNYIHSQGMIHRDLKPSNIFLDCDGQHHQMQVKIGDFGLATNHEMLSQSQKNYNQQDQSYWKYVANDNCQWWNTNQQNSPTGQDTHMWSNNYH

------------------GRAVYYSPQRRSNS-----TYT---DMLALGVILFELHWRCPPDQ-ERESVLIDVRD------GVLP-ADWAYQHPSIAPKV
                  |.. | ||.  |..      |.   || .||.|.||.. .    . ||  .| |.||      | .|  ...  .|  |  .
IQPTSMFYCEHCHHTGGVGTCLYMSPEQLSGQHYQKSHYNHKVDMYSLGIIFFEMWYPFFTTMMERVKTLTDLRDESIQFPGDFPPKWFDNKYPKQADFI

LELVAARRDQRPSARDILCDPAW
. ..    .||||| .||  .  
QWMLSHDPQQRPSAQQILQHEFF
Kinase PEK-S1_u.AA STE20 103-191 33 1.6e-24 86.72 In-house 1-91 (288) Show / Hide 
Range on Protein: 103-191
Range on HMM: 1-91/288
Sequence Identity: 33% (31 aa)

YEVLACVGQGASGKVYKCRSKEDEQI----YAIKVIKVRTATKSRDQDVALVFKEGEMLQRCEHPNIVKYFDMWKEEGEPGKSKVYIVMEFCG
|| | ..|||..|||||.. |.  ..    .|||.......   . ... ...||  ....| |||||||..    . ..  .. .||||.||
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQ-DEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTC-DDELWIVMEYCG
Kinase PEK-S1_u.AA NEK 103-190 35 2.3e-20 68.7 In-house 1-88 (286) Show / Hide 
Range on Protein: 103-190
Range on HMM: 1-88/286
Sequence Identity: 35% (34 aa)

YEVLACVGQGASGKVYKCRSKEDEQI-----YAIKVIKVRTATKSRDQD--VALVFKEGEMLQRCEHPNIVKYFDMWKEEGEPGKSKVYIVMEFC
||..  .|||. |||||.|.|.|...     |..| |..   .    |.       .|   |..  |||||||.| . ||.   ... .||||.|
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQN----NEVRILKQLKHPNIVKYYDSFIEEQ---NNCLCIVMEYC
Kinase PEK-S1_u.AA NEK1 103-190 36 3e-19 63.55 In-house 1-82 (276) Show / Hide 
Range on Protein: 103-190
Range on HMM: 1-82/276
Sequence Identity: 36% (32 aa)

YEVLACVGQGASGKVYKCRSKEDEQIYAIKVIKVRTATKSRDQDVALVFKEGEMLQRCEHPNIVKYFDMWKEEGEPGKSKVYIVMEFC
|...  .|.|. ||... ..||| | |.|| |.|   .|. ...   . .|.  |.. .|||||||..   |.|       |||||.|
YHYIKQIGEGSFGKAWLVKHKEDGQHYVIKEINV---MKMQEKEREESMNEVAILAKMKHPNIVKYKESFEENGC---GILYIVMEYC
Kinase PEK-S1_u.AA GCN2 183-263 33 3.5e-19 63.48 In-house 282-370 (511) Show / Hide 
Range on Protein: 183-263
Range on HMM: 282-370/511
Sequence Identity: 33% (30 aa)

VYIVMEFCG-RSLQSVLLGGESPPADA-----FRQLLQAVAHVHDNVGVHRDIAPHNIFVTDDGRIKLGDFGLAKN--KESMLETENIK
.||.||.|. ..| . .  .   ....     |||.| .....|..  .|||. | |||.. .|..| ||||||.|  .||  ..   |
LYIQMEYCEGKTLRQYIDNHGWCMDHDELWRYFRQILEGLNYIHSQGMIHRDLKPSNIFLDCCGNVKIGDFGLATNNKMESQINRKQQK
Kinase PEK-S1_u.AA PEK 103-179 32 6.8e-17 54.68 In-house 1-90 (655) Show / Hide 
Range on Protein: 103-179
Range on HMM: 1-90/655
Sequence Identity: 32% (29 aa)

YEVLACVGQGAS-GKVYKCRSKEDEQIYAIKVIKVRTATKS------------RDQDVALVFKEGEMLQRCEHPNIVKYFDMWKEEGEPG
.|...|.|.|.  | |||...| |.. |||| ||.  ....             .   . |..|   | |..||||| |. .| |. | .
FEEIQCLGKGGFGGQVYKVQNKLDGCYYAIKRIKLNWKQRKQPCITQECMIHKCKKHCEKVLREVKTLARLNHPNIVRYHNAWIEKPEEK
Kinase PEK-S1_u.AA NEK 211-251 38 4.9e-14 46.18 In-house 122-171 (286) Show / Hide 
Range on Protein: 211-251
Range on HMM: 122-171/286
Sequence Identity: 38% (19 aa)

QLLQAVAHVHDN-----VGVHRDIAPHNIFVTDDGR----IKLGDFGLAK
|.. |. ..||.       .|||| | ||| |....    .|.||||..|
QMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISK
Kinase PEK-S1_u.AA NEK1 209-251 36 4.8e-11 34.72 In-house 110-169 (276) Show / Hide 
Range on Protein: 209-251
Range on HMM: 110-169/276
Sequence Identity: 36% (22 aa)

FRQLLQAVAHVHDNVGVHRDIAPHNIFVT--DDG---------------RIKLGDFGLAK
| |.  |. |.||    |||| . ||| |  ..|                .|||||| |.
FCQICLALNHIHDRKILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGIAR
Kinase PEK-S1_u.AA TyrKc 103-351 18 5e-11 -44.36 SMART 1-280 (280) Show / Hide 
Range on Protein: 103-351
Range on HMM: 1-280/280
Sequence Identity: 18% (53 aa)

YEVLACVGQGASGKVYKCRSKEDEQIYAIKVIKVRTATKSRDQDVALVFKEGEMLQRC--EHPNIVKYFDMWKEEGEPGK---SKVYIVMEFC-GRSLQS
 . .   | || |.|||.. |   .  |.|..|  .        ..   .| ... .   .|||||. .    ..|.        ..||||.. . .|..
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN-FMYIEPLMIVMEYMPHGDLKD

VLLGGESPPADAFRQLLQAVAHV-------HDNVGVHRDIAPHNIFVTDDGRIKLGDFGLAKNKESM----LETENIKK-----GRAV----YYSP---Q
 |   .       ..||.    .       |..  .|||.|  |. |......| .||||... ..      ... ..|     |...     ..|   .
YLRKHRPK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECIN

RRSNSTYTDMLALGVILFELHWRCPPDQERE----SVLIDVRDGVLPADWAYQHPS--------IAPKVLELV----AARRDQRPSARDILCDP
 .  .| .|  . || ..|.  .. .  . .       ..|.  |   .   | |.          ... ..     ..  ..||. ..|  . 
YGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase PEK-S1_u.AA GCN2 103-169 27 5.5e-10 30.73 In-house 1-67 (511) Show / Hide 
Range on Protein: 103-169
Range on HMM: 1-67/511
Sequence Identity: 27% (19 aa)

YEVLACVGQGASGKVYK-CRSKEDEQIYAIKVIKVRTATKSRDQDVAL--VFKEGEMLQRCEHPNIVKYF
 |...|.|.|. |.|.|  |.. |...|||| .... . ..   .  .   ..| . | |. |...| |.
FEEICCLGKGGFGQVVKNVRNMHDGRYYAIKKWPINWKQRK---LPCKHKIMREVKLLCRLHHQHVVRYY
Kinase PEK-S1_u.AA STE20 210-250 46 1e-06 20.89 In-house 124-164 (288) Show / Hide 
Range on Protein: 210-250
Range on HMM: 124-164/288
Sequence Identity: 46% (19 aa)

RQLLQAVAHVHDNVGVHRDIAPHNIFVTDDGRIKLGDFGLA
|..||. .. | |  .||||   || .|.||..|| |||..
REVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVC
Kinase PEK-S1_u.AA Pkinase_Tyr 225-251 48 7e-06 20.52 Pfam 133-159 (270) Show / Hide 
Range on Protein: 225-251
Range on HMM: 133-159/270
Sequence Identity: 48% (13 aa)

VHRDIAPHNIFVTDDGRIKLGDFGLAK
.|||.|  |. ||... .| .|||||.
IHRDLAARNCLVTENNVVKICDFGLAR
Kinase PEK-S1_u.AA Pkinase_Tyr 103-190 26 2.7e-05 18.58 Pfam 1-89 (270) Show / Hide 
Range on Protein: 103-190
Range on HMM: 1-89/270
Sequence Identity: 26% (25 aa)

YEVLACVGQGASGKVYKCRSK----EDEQIYAIKVIKVRTATKSRDQD--VALVFKEGEMLQRC-EHPNIVKYFDMWKEEGEPGKSKVYIVMEFC
 . .   |.|| |.|||.. |    ....  |.|..|     .. ...   .  ..| ...     |||||..     ..|||.  ..|||||..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE----GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN--QIYIVMEYM
Kinase PEK-S1_u.AA GCN2 282-311 34 0.018447 3.93 In-house 434-465 (511) Show / Hide 
Range on Protein: 282-311
Range on HMM: 434-465/511
Sequence Identity: 34% (11 aa)

DMLAL-GVILFELHWR-CPPDQERESVLIDVR
|| .| |.|.||.  .  ..  || ..| . |
DMYSLGGIIFFEMWYPPFCTQMERVQILKQLR
Kinase PEK-S1_u.AA NEK 339-353 46 0.046358 3.52 In-house 272-286 (286) Show / Hide 
Range on Protein: 339-353
Range on HMM: 272-286/286
Sequence Identity: 46% (7 aa)

DQRPSARDILCDPAW
.||||...|| .|  
EQRPSCNQILEMPFI