Gene ERK-p1_b-2 (S.moellendorffii)

ERK-p1_b-2

Species: S.moellendorffii
Alias: ERK-p1_b-2
External Links:
Annotation:

Classification

Group: CMGC
Family: MAPK
Subfamily: ERK1

Sequence

Name Sequence Type Origin Length Description Download
ERK-p1_b-2.AA Protein None 369 None Fasta, JSON
ERK-p1_b-2.NA RNA None 1110 None Fasta, JSON
ERK-p1_b-2.kin_dom Protein Kinase Domain None 288 None Fasta, JSON

Protein domain

Protein domains of ERK-p1_b-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase ERK-p1_b-2.AA ERK 32-319 59 1.7e-205 688.96 In-house 1-307 (307) Show / Hide 
Range on Protein: 32-319
Range on HMM: 1-307/307
Sequence Identity: 59% (183 aa)

YAPIKPIGKGAYGVVCSATNSE-----SGEKVAIKKITNAFENTTDARRTLREIRLLRHLY-HENIIGIKDIMKPVGRSSFNDVYLVYELMDTDLHQIIR
|  ||.||.|||||||||.. |     .|.|||||||.|||... .. ||||||.||||.  |||||...|||.|. . ..||.|.| |||.|||||||.
YQIIKQIGHGAYGVVCSAIDKEYCFDETGQKVAIKKIENAFDHPIYCKRTLREIKLLRHFKGHENIICLFDIMMPNSPEQYNDIYCVEELMETDLHQIIN

SSQALTDDHCQYFIYQLLRGLKYVHSANVLHRDLKPSNLLLNASCDLKICDFGLAR---TGSDKG-----QFMTEYVVTRWYRAPELLLSCEEYTSAIDM
|.|.|.|||||||.||.|.||||.|||||.||||||||.|.|  ||||||||||||   ......     .||||||.||||||||..|| ..||.|.|.
SQQELSDDHCQYFMYQILCGLKYIHSANVIHRDLKPSNILVNSNCDLKICDFGLARCFDASYQENHECNQNFMTEYVATRWYRAPEIMLSWQKYTKAMDI

WSVGCIFAELLGRKPIFPGKDYIHQLKLIINTIGSP-EEDDLQFILSNKARSYIRSLPF--APKIPLERLYPRAN--PLALNLIDQMLVFDPKKRLTVTD
||.||||||.|||||.||||||.||. .|...||.|  |.||| | | .|. ||..||.   |..|.| ..|.||  |.|..|...||||||.||.|| .
WSCGCIFAEMLGRKPLFPGKDYVHQINRIFQIIGTPHSEEDLQYICSENAWKYIKNLPNPVRPPKPWENIFPNANCNPQAIDLLEKMLVFDPDKRITVEE

ALEHPYL
.|||||.
CLEHPYF
Kinase ERK-p1_b-2.AA MAPK 32-319 55 1e-196 659.81 In-house 1-328 (328) Show / Hide 
Range on Protein: 32-319
Range on HMM: 1-328/328
Sequence Identity: 55% (182 aa)

YAPIKPIGKGAYGVVCSATNSE------SGEKVAIKKITNAFENTTDARRTLREIRLLRHL-YHENIIGIKDIMKP------VGRSSFNDVYLVYELMDT
| ..||||.|||||||||.  .      .|.||||||| ..|.|.|...||.|||.||||.  |||||...||..|        ...|||.|.| |||.|
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

DLHQIIRSSQALTDDHCQYFIYQLLRG--LKYVHSANVLHRDLKPSNLLLNASCDLKICDFGLARTGSDK----GQ----------FMTEYVVTRWYRAP
||||||.| | |.|||.|||.||.|||  ||| |||||.||||||||.|.|  ||||||||||||.  ..    .|          .|||||.|||||||
DLHQIIKSQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAP

ELLLS--CEEYTSAIDMWSVGCIFAELLG-RKPIFPGKDYIHQLKLIINTIGSPEEDDLQFIL-SNKARSYIRSL---PFAPKIPLERLYPR----ANPL
|..|.    .|| |.|||||||||||.|. |||.|||||||.|..||....|.|.|...|.|  | .||.||.||   |  ||.|.| ..|     |||.
EIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANPQ

ALNLIDQMLVFDPKKRLTVTDALEHPYL
|..|...||||||.||.|| .||.|||.
AIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase ERK-p1_b-2.AA CMGC 32-319 28 8.10000000001e-150 496.08 In-house 1-513 (513) Show / Hide 
Range on Protein: 32-319
Range on HMM: 1-513/513
Sequence Identity: 28% (149 aa)

YAPIKPIGKGAYGVVCSATN--------------SESGEKVAIKKITNAFENTTDAR----------RTLREIRLLRHL-----------------YHEN
|  ||.||.|.||||.....               |..|.|||||| |.| ....|.          |.||||..|.||                  |.|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IIGIKDIMKPVG-RSS-----------FNDVYLVYELMDTDLHQIIRSSQ---------ALTDDH------------CQYFI------YQLLRGLK--YV
|....|| .. . ...           ||..||| |.||.||.|.|.. |          |.. |            ..||.      ||.|||||  | 
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HSAN--VLHRDLKPSNLLLNASCDL--------------------KICDFGLAR-TGSDKGQ--------------------FMTEYVVTRWYRAPELLL
||..  ..||||||.|.|.|  |.|                    ||||||||| ... ...                    ..|.|||||||||||.||
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILL

SCEEYT---------SAIDMWSVGCIFAELLGR--------KPIFP-----------GKDYIHQLKLIINTIGSP----------------EEDDLQF--
....||         ..||||||||||||.. .        ||.||           ||..|.||..|....|.|                ||.. ..  
GWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIK

------------------ILSNKARSYIRS---LPFAPKIPLERLYPR-----------------------------------ANPLALNLIDQMLVFDP
                  ..| .|| ||.|   .|  |..|...|.|.                                   ..|.|..|...||..||
LPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDP

KKRLTVTDALEHPYL
.||.|. .||.|||.
DKRITAEQALQHPYF
Kinase ERK-p1_b-2.AA p38 32-319 47 1.3e-148 500.03 In-house 1-289 (289) Show / Hide 
Range on Protein: 32-319
Range on HMM: 1-289/289
Sequence Identity: 47% (139 aa)

YAPIKPIGKGAYGVVCSATNSESGEK---VAIKKITNAFENTTDARRTLREIRLLRHLYHENIIGIKDIMKP--VGRSSFNDVYLVYELMDTDLHQIIRS
|  ..|.|.|||| ||.|  ...|.|   |||||.   |. . .|.|| ||.|||.|. |||.|.. |.  |    ...|.|||.| ..|..||..|.. 
YQNLQPVGSGAYGQVCKAEDRRTGQKRRYVAIKKLMRPFQSEIHAKRTYRELRLLKHMRHENVICLLDVFTPPAHSMNDFQDVYMVTHFMGADLNNIMK-

SQALTDDHCQYFIYQLLRGLKYVHSANVLHRDLKPSNLLLNASCDLKICDFGLARTGSDKGQFMTEYVVTRWYRAPELLLSCEEYTSAIDMWSVGCIFAE
.|.|.||| |. .||.||||||.|||.. ||||||||. .|  |.|.| ||||||    . . ||.||.|||||||| .|.  .|| ..|.|||||| ||
CQRLSDDHIQFLVYQILRGLKYIHSAGIIHRDLKPSNIAVNEDCELRILDFGLAR---HCDDEMTGYVATRWYRAPEIMLNWMHYTQTVDIWSVGCIMAE

LLGRKPIFPGKDYIHQLKLIINTIGSPEEDDLQFILSNKARSYIRSLPFAPKIPLERLYPRANPLALNLIDQMLVFDPKKRLTVTDALEHPYL
|. ... |||.|.|.||. |.. .|.|.|  .| | | .||.||.|.|  |.  .......|||.|..|.. ||. || ||.|. .|..|||.
LITGRTLFPGDDHIDQLQRIMKVCGTPDEEFWQKIQSEEARNYIQSYPQMPRRDFHHVFMGANPQAIDLLEKMLELDPDKRITAEEAMQHPYF
Kinase ERK-p1_b-2.AA ERK5 32-319 53 5.8e-145 487.88 In-house 1-295 (295) Show / Hide 
Range on Protein: 32-319
Range on HMM: 1-295/295
Sequence Identity: 53% (157 aa)

YAPIKPIGKGAYGVVCSATNSESGEKVAIKKITNAFENTTDARRTLREIRLLRHLYHENIIGIKDIMKP-VGRSSFNDVYLVYELMDTDLHQIIRSSQAL
| .|  || ||||||||| .   |..|||||| |||.  | |.||.||...|||  |.||| |.||..| |  | . ||| |..||. |||||| |.| .
YKIIEKIGNGAYGVVCSARRRKNGQQVAIKKIPNAFDVVTNAKRTFRELKILRHFRHDNIIAIRDILMPKVPYSEMKDVYVVFDLMESDLHQIIHSNQPF

TDDHCQYFIYQLLRGLKYVHSANVLHRDLKPSNLLLNASCDLKICDFGLARTGSD-----KGQFMTEYVVTRWYRAPELLLSCEEYTSAIDMWSVGCIFA
| .|  ||.||.||||||.|||.|.|||||||||| |  |.||| |||.||  .      .  |||||| |||||||||..| ..|| |||.||||||| 
TLEHIRYFLYQILRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTFSPDKHQMFMTEYVATRWYRAPELMFSSHDYTQAIDVWSVGCIFG

ELLGRKPIFPGKDYIHQLKLIINTIGSPEEDDLQFILSNKARSYIRS-LPFAPKIPLERLYPRANPLALNLIDQMLVFDPKKRLTVTDALEHPYL
|...|. .|||| |||||.||.  .| |    .| . ... . |. . .|     ..|..||.| . ||.|. .||.|.| .|.||  || ||.|
EMIARRQMFPGKNYIHQLQLIMMVLGMPPPHMIQAVSADHVYNYFQKNFPNRQPKDWEKVYPKADRQALDLLARMLRFEPSERITVNKALQHPFL
Kinase ERK-p1_b-2.AA ERK1 32-319 56 9.90000000001e-141 473.83 In-house 1-289 (289) Show / Hide 
Range on Protein: 32-319
Range on HMM: 1-289/289
Sequence Identity: 56% (165 aa)

YAPIKPIGKGAYGVVCSATNSESGEKVAIKKITNAFENTTDARRTLREIRLLRHLYHENIIGIKDIMKPVGRSSFNDVYLVYELMDTDLHQIIRSSQALT
|  .. ||.||||.||||     ...||||||   ||  |   ||||||..|    |||||.|.||..     .. |||.| .||.||| .... .| | 
YTNLQYIGEGAYGMVCSAYDTVHKQRVAIKKIS-PFEHQTYCQRTLREIKILTRFKHENIINIQDIIRADTIEQMRDVYIVQCLMETDLYKLLK-TQHLS

DDHCQYFIYQLLRGLKYVHSANVLHRDLKPSNLLLNASCDLKICDFGLART---GSDKGQFMTEYVVTRWYRAPELLLSCEEYTSAIDMWSVGCIFAELL
 ||  ||.||.||||||.||||||||||||||||||  ||||||||||||    . |   |.|||| ||||||||..|    || .||.|||||| ||.|
NDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEML

GRKPIFPGKDYIHQLKLIINTIGSPEEDDLQFILSNKARSYIRSLPFAPKIPLERLYPRANPLALNLIDQMLVFDPKKRLTVTDALEHPYL
  .|||||| |. || .|.  .||| .|||. |. .|||.|..|||. ||.|..||.|.| . || |.|.|| | |.||.|| .|| ||||
SNRPIFPGKHYLDQLNHILGVLGSPSQDDLNCIINEKARNYLQSLPHKPKVPWARLFPKADSKALDLLDKMLTFNPHKRITVEEALAHPYL
Kinase ERK-p1_b-2.AA ERK7 32-319 45 2.5e-127 429.29 In-house 1-292 (292) Show / Hide 
Range on Protein: 32-319
Range on HMM: 1-292/292
Sequence Identity: 45% (135 aa)

YAPIKPIGKGAYGVVCSATNSESGEKVAIKKITNAFENTTDARRTLREIRLLRHLY-HENIIGIKDIMKPVGRSSFNDVYLVYELMDTDLHQIIRSSQAL
|  .| .||||||.|  |.   ... ||.|||  || | ||| || ||| .|. .  |.||| . ....    .   |.|||.| |.|||| .||  . |
YEIRKRLGKGAYGIVWKAYDKRTKQVVALKKIFDAFRNQTDAQRTFREIMFLQEFHCHPNIIRLINVIR---ADNDRDIYLVFEFMETDLHAVIRKGNIL

TDDHCQYFIYQLLRGLKYVHSANVLHRDLKPSNLLLNASCDLKICDFGLARTGSDKG------QFMTEYVVTRWYRAPELLLSCEEYTSAIDMWSVGCIF
 | | || .||||| .||.||.||.||||||||.||.. | .|.|||||||. ...       . .|||| |||||||| ||. ..|| ..||||.||| 
KDIHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMWSIGCIL

AELLGRKPIFPGKDYIHQLKLIINTIGSPEEDDLQFILSNKARSYIRSLPFAPKIPLERLYPRANPLALNLIDQMLVFDPKKRLTVTDALEHPYL
.|.|  ||.|||   ..|. .|..||. | . |.. | |. | . . ...  .. .|. ..| . . |..|. ..||| ||||||...||.||| 
GEMLRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMPQCCDDAIDLLKRLLVFNPKKRLTAEQALQHPYV
Kinase ERK-p1_b-2.AA nmo 33-319 47 5e-120 370.97 In-house 2-292 (292) Show / Hide 
Range on Protein: 33-319
Range on HMM: 2-292/292
Sequence Identity: 47% (137 aa)

APIKPIGKGAYGVVCSATNSESGEKVAIKKITNAFENTTDARRTLREIRLLRHLYHENIIGIKDIMKPVGRSSFNDVYLVYELMDTDLHQIIRSSQALTD
 | .||| ||.||| | |   .| .||.||. | | |   ..|  ||...|    |.|..  .||..|   . |...| | |||  |||.|| | |.|. 
QPDRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDILQPPHKDFFQEIYVVTELMQSDLHKIIVSPQHLSS

DHCQYFIYQLLRGLKYVHSANVLHRDLKPSNLLLNASCDLKICDFGLART-GSDKGQFMTEYVVTRWYRAPELLLSCEEYTSAIDMWSVGCIFAELLGRK
|| . |.||.||||||.||||.||||.|| |||.|. | ||||||||||.   |. . ||. ||| .|||||.|.    ||||.|.|||||||||||||.
DHVKVFLYQILRGLKYLHSANILHRDIKPGNLLVNSNCVLKICDFGLARVWEQDQSKHMTQEVVTQYYRAPEILMGARHYTSAVDIWSVGCIFAELLGRR

PIFPGKDYIHQLKLIINTIGSPEEDDLQFILSNKARSYIRSLPFAPKIP-LERLYP--RANPLALNLIDQMLVFDPKKRLTVTDALEHPYL
 .|  .  |.||..|.. .| |  .|...         .|  . .|... | .|     |.  | .|. .||.||| ||. ..|||.||||
ILFQAQSPIQQLQMITDLLGTPSMEDMKYACEGAKAHMLRMPHKPPCLQVLYTLSSPDHATHEAVHLLCRMLHFDPDKRISCKDALAHPYL
Kinase ERK-p1_b-2.AA CDK 32-319 35 4e-111 356.8 In-house 1-284 (284) Show / Hide 
Range on Protein: 32-319
Range on HMM: 1-284/284
Sequence Identity: 35% (114 aa)

YAPIKPIGKGAYGVVCSATNSESG-----EKVAIKKITNAF-----ENTTDARRTLREIRLLRHLYHENIIGIKDIMKPV-------GRSSF-NDVYLVY
|  .. || |.||||  | . ..|     . ||.|||         | .     ..||| ||..| |.||. ..|.           ..  . | .|.| 
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDK--HENKLYMVF

ELMDTDLHQIIRSSQALTDDHCQYFIYQLLRGLKYVHSANVLHRDLKPSNLLLNASCD-----LKICDFGLARTGSD------KGQFMTEYVVTRWYRAP
| ||.|| ....         .. ...|||||| | || ...||||||.|.|.|         ||| ||||||  .       . . .|  |||.|||||
EYMDHDLKKYMD---------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAP

ELLLSCEEYT--SAIDMWSVGCIFAELLG---RKPIFPGKDYIHQLKLIINTIGSPEEDDLQFILSNKARSYIRSLPFAPKIPLERLYPRANPLALNLID
|||| ...|.   .||||||||||||..    |||.|||.  |.||..|....|.| ||.   . .                              .|..
ELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY--------------------------DLLN

QMLVFDPKKRLTVTDALEHPYL
.||..|||||.. ..||.|||.
KMLCYDPKKRISAEQALQHPYF
Kinase ERK-p1_b-2.AA S_TKc 32-319 29 2.5e-101 343.88 SMART 1-231 (231) Show / Hide 
Range on Protein: 32-319
Range on HMM: 1-231/231
Sequence Identity: 29% (90 aa)

YAPIKPIGKGAYGVVCSATNSESGEKVAIKKITNAFENTTDARRTLREIRLLRHLYHENIIGIKDIMKPVGRSSFNDVYLVYELMDT---DLHQIIRSSQ
|  ...|||||.|.|. ... ..|..||||.|          ....|||..|..  |.||. ..|..        ...|.| |..|.   ||...|.. .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD------DHLYMVMEYCDGDLGDLFDYIKKRG

A------LTDDHCQYFIYQLLRGLKYVHSANVLHRDLKPSNLLLNASCDLKICDFGLARTGSDKGQFMTEYVVTRWYRAPELLLSCEEYTS-AIDMWSVG
       ..  |.....||....|.| || ...||||||.|.||.    .|||||||||         | ...|.||.|||.|     |.  ..|.||.|
RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDWWSCG

CIFAELLGRKPIFPGKDYIHQLKLIINTIGSPEEDDLQFILSNKARSYIRSLPFAPKIPLERLYPRANPLALNLIDQMLVFDPKKRLTVTDALE------
||..|.| ..| ||      |...... ||                                      | |...|...|..||.||.|. .||.      
CILYEMLCGYPPFP------QMQMMFKKIG-------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIK

-HPYL
 ||..
CHPWF
Kinase ERK-p1_b-2.AA Pkinase 32-319 29 3.8e-100 343.82 Pfam 1-293 (293) Show / Hide 
Range on Protein: 32-319
Range on HMM: 1-293/293
Sequence Identity: 29% (92 aa)

YAPIKPIGKGAYGVVCSATNSESGEKVAIKKITNAFENTTDARRTLR--EIRLLRHLYHENIIGIKDIMKPVGRSSFNDVYLVYELMDT-----DLHQII
|  ...||.|..|.|. ...  .|..||.|.|    |.    .. .|  ||.....| |.||. ..|..        ...|.| |...      ||. .|
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-----KDHIYMVMEYCEGGLYVMDLFDYI

R--SSQAL--TDDHCQYFIYQLLRGLKYVHSANVLHRDLKPSNLLLNASCDL----KICDFGLARTG-SDKGQFMTEYVVTRWYRAPELLLSCEEYTSAI
.  .. ..  ....|. ..||.||||.| || ...||||||.|.|..  ...    ||||||||.     ... || ...|.||.|||.......|....
STWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKV

DMWSVGCIFAELLGRKPIFPGK----DYIHQLKLIINTIGSPEEDDLQFILSNKARSYIRSLPFAPKIPLERLYPRANPLALNLIDQMLVFDPKKRLTVT
||||.|||..|.| ..|.|||.    . . |...| .. | | . | .   |.  .. .|  . .  . .... ..... .. .|. .| .|||||.| .
DMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H--F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAE

DALEHPYL
..|.||..
QILQHPWF
Kinase ERK-p1_b-2.AA MAPK-Unclassified 32-181 52 5.1e-85 288.75 In-house 1-157 (575) Show / Hide 
Range on Protein: 32-181
Range on HMM: 1-157/575
Sequence Identity: 52% (83 aa)

YAPIKPIGKGAYGVVCSATNSES-GEKVAIKKITNAFENTTDARRTLREIRLLRHLYHENIIGIKDIMKPVGRSS--FNDVYLVYELMDT---DLHQIIR
| ..| || ||||.|| |. . . . .|||||.. .|.| ||..|.|||||.||.| |.||| |.||  . . .   | |.|.| ..| |   ||||||.
YEYQKNIGSGAYGQVCRAMDKKNQNQQVAIKKVNHIFHNHTDCKRVLREIRILRYLNHPNIIQIQDIFYNKELHNQEFDDIYIVMDYMQTSLFDLHQIIK

SSQ-ALTDDHCQYFIYQLLRGLKYVHSANVLHRDLKPSNLLLNASCDLKICDFGLAR
| |  . . | |||.||.|||||| |||...||||||||||.|  | ..|||||..|
SNQDHWCHQHIQYFFYQILRGLKYLHSACIIHRDLKPSNLLINQDCSVRICDFGMSR
Kinase ERK-p1_b-2.AA MAPK-Unclassified 190-319 35 8.6e-60 204.95 In-house 405-575 (575) Show / Hide 
Range on Protein: 190-319
Range on HMM: 405-575/575
Sequence Identity: 35% (60 aa)

MTEYVVTRWYRAPELLLSCEEYTSAIDMWSVGCIFAELLGR-----------KPIFPGKD--------------------YIHQLKLIINTIGSPEEDDL
||.|||||||||||..||  ||. ..|.||.||||||.. .           .|.|||.|                    .. |.|.|.   |.|.| |.
MTQYVVTRWYRAPEIMLSMHEYDTQVDIWSIGCIFAEMMQMYDRHNPTFSDHRPLFPGQDCFPITPDRNNDVDQGGFPHSHQDQIKMIFDYLGMPPEEDC

QFILSNKARSYIRSLPFAPKIPLERLYPRANP----------LALNLIDQMLVFDPKKRLTVTDALEHPYL
.|| . .|| ||.|.   . ..   |.. ..|          ........||.|.|.|| |  .|||||| 
NFITCDSARKYIQSFKCKTPVHFTDLMFCKAPGDDQIVRGNCECIDFVQKMLQFNPWKRITADQALEHPYF
Kinase ERK-p1_b-2.AA TyrKc 32-319 21 2.1e-14 10.14 SMART 1-280 (280) Show / Hide 
Range on Protein: 32-319
Range on HMM: 1-280/280
Sequence Identity: 21% (69 aa)

YAPIKPIGKGAYGVVCSATNSESGEKVAIKKIT-NAFENTTDARRTLREIRLLRHL--YHENIIGIKDIMKPVGRSSF---NDVYLVYELMDT-DLHQII
   .| .| ||.|.|. .| .   ..||.|..  .|       .  .||.|....|   |.||. .  .    ||  |     ...| |.|.  ||.. .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN-FMYIEPLMIVMEYMPHGDLKDYL

RSSQA-LTDDHCQYFIYQLLRGLKYVHSANVLHRDLKPSNLLLNASCDLKICDFGLARTGSDK-------GQFMT-----EY--VVTRWYRAPELLLSCE
|...  |. ..  .| .|  .|  | || |. ||||   | |...    ||.||||.| . |.          ..     .   .  ||. ||| .  . 
RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APECINYG-

EYTSAIDMWSVGCIFAEL--LGRKPIFP------GKDYIHQLKLIINTIGSPEE----DDLQFILSNKARSYIRSLPFAPKIPLERLYPRANPLALNLID
..|.. | || |    |.  .| .|           . ....    .    |..                                 .... .   ... 
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS----------------------------FVCCPDEMYQIMK

QMLVFDPKKRLTVTDALEHPYL
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QCWHEDPEDRPTFSEI--HECF
Kinase ERK-p1_b-2.AA Pkinase_Tyr 35-219 27 7.2e-12 40.82 Pfam 4-199 (270) Show / Hide 
Range on Protein: 35-219
Range on HMM: 4-199/270
Sequence Identity: 27% (57 aa)

IKPIGKGAYGVVCSATNS----ESGEKVAIKKITNAFENTTDA----RRTLREIRLLRHL-YHENIIGIKDIMKPVGRSSFNDVYLVYELMDT-DLHQII
.| .|.||.|.|. .|      . . .||.|..    |....     .  .||......| .|.||.    .  . |...   .|.| |.|   ||.   
GKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLK---EGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN--QIYIVMEYMPHGDLLDYL

RS----SQALTDDHCQYFIYQLLRGLKYVHSANVLHRDLKPSNLLLNASCDLKICDFGLARTGSDKGQFMTEY-VVT-------RWYRAPELLLSCEEYT
|.     |.||  .   . .|  .|. | .| |  ||||   | |.. .   |||||||||.     .   .| ...       .|. ||| .  .. .|
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI----YNDDYYYRKRGGGKLPIKWM-APECINYGK-FT

SAIDMWS
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TKSDVWS