Gene ERK-p1_a-2 (S.moellendorffii)

ERK-p1_a-2

Species: S.moellendorffii
Alias: ERK-p1_a-2
External Links:
Annotation:

Classification

Group: CMGC
Family: MAPK
Subfamily: ERK1

Sequence

Name Sequence Type Origin Length Description Download
ERK-p1_a-2.AA Protein None 231 None Fasta, JSON
ERK-p1_a-2.NA RNA None 696 None Fasta, JSON
ERK-p1_a-2.kin_dom Protein Kinase Domain None 176 None Fasta, JSON

Protein domain

Protein domains of ERK-p1_a-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase ERK-p1_a-2.AA ERK 1-176 57 5.9e-117 394.86 In-house 119-307 (307) Show / Hide 
Range on Protein: 1-176
Range on HMM: 119-307/307
Sequence Identity: 57% (108 aa)

RGLKYIHSANVLHRDLKPGNLLLNANCDLKIADFGLAR---TGREKG-----QFMTEYVVTRWYRAPELLLSCEDYTSAIDIWSVGCIFAELLGRKPIFP
.||||||||||.||||||.|.|.| ||||||.||||||   .. ...     .||||||.||||||||..|| ..||.|.||||.||||||.|||||.||
CGLKYIHSANVIHRDLKPSNILVNSNCDLKICDFGLARCFDASYQENHECNQNFMTEYVATRWYRAPEIMLSWQKYTKAMDIWSCGCIFAEMLGRKPLFP

GKNYINQLKLIIDVIGSP-KESQLGFISNHKARSYIRSLPP--TPRVPLSRLYPHAN--PQALQLIERMLAFDPKERITVSEALDHPYF
||.|..|. .|...||.|  | .|  | . .|. ||..||    | .|.. ..| ||  |||. |.|.||.|||..|||| |.| ||||
GKDYVHQINRIFQIIGTPHSEEDLQYICSENAWKYIKNLPNPVRPPKPWENIFPNANCNPQAIDLLEKMLVFDPDKRITVEECLEHPYF
Kinase ERK-p1_a-2.AA MAPK 1-176 54 5.6e-116 391.6 In-house 126-328 (328) Show / Hide 
Range on Protein: 1-176
Range on HMM: 126-328/328
Sequence Identity: 54% (111 aa)

RG--LKYIHSANVLHRDLKPGNLLLNANCDLKIADFGLARTGREK----GQ----------FMTEYVVTRWYRAPELLLS--CEDYTSAIDIWSVGCIFA
||  |||||||||.||||||.|.|.| ||||||.||||||.   .    .|          .|||||.||||||||..|.    .|| |.|.||||||||
RGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAPEIMLNWIWMHYTKAVDMWSVGCIFA

ELLG-RKPIFPGKNYINQLKLIIDVIGSPKESQLGFIS-NHKARSYIRSL---PPTPRVPLSRLYP----HANPQALQLIERMLAFDPKERITVSEALDH
|.|. |||.||||.||.|..||..|.|.|.|  . .|. ...||.||.||   |..|..|.. ..|    .|||||. |.|.||.|||..|||| ||| |
EMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANPQAIDLLEKMLVFDPDKRITVEEALQH

PYF
|||
PYF
Kinase ERK-p1_a-2.AA CMGC 1-176 29 1.5e-96 317.83 In-house 191-513 (513) Show / Hide 
Range on Protein: 1-176
Range on HMM: 191-513/513
Sequence Identity: 29% (96 aa)

RGLK--YIHSAN--VLHRDLKPGNLLLNANCDL--------------------KIADFGLAR-TGREKGQ--------------------FMTEYVVTRW
||||  |.||..  ..|||||| |.|.| ||.|                    ||.|||||| .. ....                    ..|.||||||
RGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRW

YRAPELLLSCEDYT---------SAIDIWSVGCIFAELLGR--------KPIFP-----------GKNYINQLKLIIDVIGSP----------------K
|||||.||....||         ..||.|||||||||.. .        ||.||           ||..|.||..|..|.|.|                .
YRAPEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHE

ESQLGFIS--------------------NHKARSYIRS---LPPTPRVPLSRLYPH-----------------------------------ANPQALQLI
|   ..|.                    ...|| ||.|   .|. |. |...|.|                                    ..|||. |.
EEWPNMIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLL

ERMLAFDPKERITVSEALDHPYF
..|| .||..|||...||.||||
KKMLQYDPDKRITAEQALQHPYF
Kinase ERK-p1_a-2.AA p38 1-176 52 1.8e-94 320.18 In-house 117-289 (289) Show / Hide 
Range on Protein: 1-176
Range on HMM: 117-289/289
Sequence Identity: 52% (92 aa)

RGLKYIHSANVLHRDLKPGNLLLNANCDLKIADFGLARTGREKGQFMTEYVVTRWYRAPELLLSCEDYTSAIDIWSVGCIFAELLGRKPIFPGKNYINQL
|||||||||.. ||||||.|. .| .|.|.| ||||||   .. . ||.||.|||||||| .|.  .|| ..|||||||| |||. ... |||...|.||
RGLKYIHSAGIIHRDLKPSNIAVNEDCELRILDFGLAR---HCDDEMTGYVATRWYRAPEIMLNWMHYTQTVDIWSVGCIMAELITGRTLFPGDDHIDQL

KLIIDVIGSPKESQLGFISNHKARSYIRSLPPTPRVPLSRLYPHANPQALQLIERMLAFDPKERITVSEALDHPYF
. |. |.|.|.|  .  |....||.||.|.|..||  ...... |||||. |.|.||  ||  |||..||. ||||
QRIMKVCGTPDEEFWQKIQSEEARNYIQSYPQMPRRDFHHVFMGANPQAIDLLEKMLELDPDKRITAEEAMQHPYF
Kinase ERK-p1_a-2.AA ERK1 1-176 61 1.9e-91 310.13 In-house 111-289 (289) Show / Hide 
Range on Protein: 1-176
Range on HMM: 111-289/289
Sequence Identity: 61% (110 aa)

RGLKYIHSANVLHRDLKPGNLLLNANCDLKIADFGLART---GREKGQFMTEYVVTRWYRAPELLLSCEDYTSAIDIWSVGCIFAELLGRKPIFPGKNYI
|||||||||||||||||| |||||  ||||| ||||||    . .   |.|||| ||||||||..|    || .||||||||| ||.|  .|||||| |.
RGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYL

NQLKLIIDVIGSPKESQLGFISNHKARSYIRSLPPTPRVPLSRLYPHANPQALQLIERMLAFDPKERITVSEALDHPYF
 || .|. |.||| .  |  | |.|||.|..|||  |.||. ||.|.| ..|| |...||.| |..|||| ||| ||| 
DQLNHILGVLGSPSQDDLNCIINEKARNYLQSLPHKPKVPWARLFPKADSKALDLLDKMLTFNPHKRITVEEALAHPYL
Kinase ERK-p1_a-2.AA ERK5 1-176 54 3.9e-89 302.44 In-house 114-295 (295) Show / Hide 
Range on Protein: 1-176
Range on HMM: 114-295/295
Sequence Identity: 54% (99 aa)

RGLKYIHSANVLHRDLKPGNLLLNANCDLKIADFGLAR---T--GREKGQFMTEYVVTRWYRAPELLLSCEDYTSAIDIWSVGCIFAELLGRKPIFPGKN
|||||.|||.|.|||||| ||| | ||.||| |||.||   |    ..  |||||| |||||||||..| .||| |||.||||||| |...|. .|||||
RGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTFSPDKHQMFMTEYVATRWYRAPELMFSSHDYTQAIDVWSVGCIFGEMIARRQMFPGKN

YINQLKLIIDVIGSPKESQLGFISNHKARSYIRS-LPPTPRVPLSRLYPHANPQALQLIERMLAFDPKERITVSEALDHPYF
||.||.||..|.| |    .  .|  . . |. . .|.   ......|| | .|||.|. ||| |.| ||||| .|| ||. 
YIHQLQLIMMVLGMPPPHMIQAVSADHVYNYFQKNFPNRQPKDWEKVYPKADRQALDLLARMLRFEPSERITVNKALQHPFL
Kinase ERK-p1_a-2.AA CDK 1-176 40 3.1e-78 249.86 In-house 119-284 (284) Show / Hide 
Range on Protein: 1-176
Range on HMM: 119-284/284
Sequence Identity: 40% (79 aa)

RGLKYIHSANVLHRDLKPGNLLLNANCD-----LKIADFGLARTGRE------KGQFMTEYVVTRWYRAPELLLSCEDYT--SAIDIWSVGCIFAELLG-
||| |.|| ...|||||| |.|.| |       ||||||||||          . . .|  |||.||||||||| ...|.   .||.|||||||||..  
RGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTD

--RKPIFPGKNYINQLKLIIDVIGSPKESQL-GFISNHKARSYIRSLPPTPRVPLSRLYPHANPQALQLIERMLAFDPKERITVSEALDHPYF
  |||.|||.. |.||..|....|.| |..  |. .                               .|...||..||| ||. ..||.||||
VTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY---------------------------DLLNKMLCYDPKKRISAEQALQHPYF
Kinase ERK-p1_a-2.AA ERK7 1-176 43 9.5e-77 261.29 In-house 111-292 (292) Show / Hide 
Range on Protein: 1-176
Range on HMM: 111-292/292
Sequence Identity: 43% (79 aa)

RGLKYIHSANVLHRDLKPGNLLLNANCDLKIADFGLAR--TGRE----KGQFMTEYVVTRWYRAPELLLSCEDYTSAIDIWSVGCIFAELLGRKPIFPGK
| .||.||.||.|||||| |.||...| .|..||||||  . .|    . . .|||| |||||||| ||. . || ..| ||.||| .|.|  ||.||| 
RAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMWSIGCILGEMLRGKPMFPGT

NYINQLKLIIDVIGSPKESQLGFISNHKARSYIRSLPPTPRVPLSRLYPHANPQALQLIERMLAFDPKERITVSEALDHPYF
  .||. .|...|. |..  .  |  | | . . ... ..| .|. ..|.. ..|. |. |.|.| ||.|.|. .|| ||| 
STMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMPQCCDDAIDLLKRLLVFNPKKRLTAEQALQHPYV
Kinase ERK-p1_a-2.AA nmo 1-176 50 3.8e-73 224.11 In-house 113-292 (292) Show / Hide 
Range on Protein: 1-176
Range on HMM: 113-292/292
Sequence Identity: 50% (90 aa)

RGLKYIHSANVLHRDLKPGNLLLNANCDLKIADFGLART-GREKGQFMTEYVVTRWYRAPELLLSCEDYTSAIDIWSVGCIFAELLGRKPIFPGKNYINQ
|||||.||||.||||.||||||.|.|| ||| ||||||.  ... . ||. ||| .|||||.|.    ||||.|||||||||||||||. .|  .. |.|
RGLKYLHSANILHRDIKPGNLLVNSNCVLKICDFGLARVWEQDQSKHMTQEVVTQYYRAPEILMGARHYTSAVDIWSVGCIFAELLGRRILFQAQSPIQQ

LKLIIDVIGSPKESQLGFISNHKARSYIRSLPPTPRVP-LSRLYP--HANPQALQLIERMLAFDPKERITVSEALDHPYF
|..|.|..| |   .. .  .      .|  .  | .. | .|    ||.  | .|. ||| |||  || . .|| ||| 
LQMITDLLGTPSMEDMKYACEGAKAHMLRMPHKPPCLQVLYTLSSPDHATHEAVHLLCRMLHFDPDKRISCKDALAHPYL
Kinase ERK-p1_a-2.AA Pkinase 1-176 32 3.2e-62 217.82 Pfam 119-293 (293) Show / Hide 
Range on Protein: 1-176
Range on HMM: 119-293/293
Sequence Identity: 32% (60 aa)

RGLKYIHSANVLHRDLKPGNLLLNANCDL----KIADFGLARTG-REKGQFMTEYVVTRWYRAPELLLSCEDYTSAIDIWSVGCIFAELLGRKPIFPGK-
|||.|.|| ...|||||| |.|.. |...    ||.|||||.     ... || ...|.||.|||.......|....|.||.|||..|.| ..|.|||. 
RGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHC

---NYINQLKLIIDVIGSPKESQLGFISNHKARSYIRSLPPTPRVPLSRLYPHANPQALQLIERMLAFDPKERITVSEALDHPYF
   | ..|...|  . | | ...    ..   .. .|  . .    .... . ... ....|...|..|||.|.|  ..| ||.|
WHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H--F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase ERK-p1_a-2.AA MAPK-Unclassified 47-176 35 8.6e-60 204.96 In-house 405-575 (575) Show / Hide 
Range on Protein: 47-176
Range on HMM: 405-575/575
Sequence Identity: 35% (60 aa)

MTEYVVTRWYRAPELLLSCEDYTSAIDIWSVGCIFAELLGR-----------KPIFPGKN--------------------YINQLKLIIDVIGSPKESQL
||.|||||||||||..||  .|. ..||||.||||||.. .           .|.|||..                    .. |.|.|.|. |.|.|  .
MTQYVVTRWYRAPEIMLSMHEYDTQVDIWSIGCIFAEMMQMYDRHNPTFSDHRPLFPGQDCFPITPDRNNDVDQGGFPHSHQDQIKMIFDYLGMPPEEDC

GFISNHKARSYIRSLPPTPRVPLSRLYPHANP----------QALQLIERMLAFDPKERITVSEALDHPYF
 || . .|| ||.|. . ..|. . |.. ..|          ... ..  ||.|.|. |||  .|| ||||
NFITCDSARKYIQSFKCKTPVHFTDLMFCKAPGDDQIVRGNCECIDFVQKMLQFNPWKRITADQALEHPYF
Kinase ERK-p1_a-2.AA MAPK-Unclassified 1-38 63 9.6e-22 75.02 In-house 120-157 (575) Show / Hide 
Range on Protein: 1-38
Range on HMM: 120-157/575
Sequence Identity: 63% (24 aa)

RGLKYIHSANVLHRDLKPGNLLLNANCDLKIADFGLAR
|||||.|||...|||||| |||.| .| ..|.|||..|
RGLKYLHSACIIHRDLKPSNLLINQDCSVRICDFGMSR
Kinase ERK-p1_a-2.AA S_TKc 1-176 21 6.5e-16 56.42 SMART 19-231 (231) Show / Hide 
Range on Protein: 1-176
Range on HMM: 19-231/231
Sequence Identity: 21% (59 aa)

RGLK--------------------------------------------------------------------------------------YIHSANVLHR
|  |                                                                                      |.|| ...||
RHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPEHARFYMYQICCALEYCHSHGIIHR

DLKPGNLLLNANCDLKIADFGLARTGREKGQFMTEYVVTRWYRAPELLLSCEDYTS-AIDIWSVGCIFAELLGRKPIFPGKNYINQLKLIIDVIGSPKES
|||| |.||.    .||.||||||         | ...|.||.|||.|     |.  ..|.||.|||..|.| ..| ||      |.......||     
DLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEMLCGYPPFP------QMQMMFKKIG-----

QLGFISNHKARSYIRSLPPTPRVPLSRLYPHANPQALQLIERMLAFDPKERITVSEALD-------HPYF
                                 |.|...|...| .||..|.|. |||        ||.|
--------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase ERK-p1_a-2.AA Pkinase_Tyr 1-76 33 2.4e-05 18.74 Pfam 122-199 (270) Show / Hide 
Range on Protein: 1-76
Range on HMM: 122-199/270
Sequence Identity: 33% (28 aa)

RGLKYIHSANVLHRDLKPGNLLLNANCDLKIADFGLARTGREKGQFMTEY-VVT-------RWYRAPELLLSCEDYTSAIDIWS
.|. | .| |  ||||   | |.. |   ||.||||||.     .   .| ...       .|. ||| .  .. .|.. |.||
KGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI----YNDDYYYRKRGGGKLPIKWM-APECINYGK-FTTKSDVWS