Gene ERK5_b (S.moellendorffii)

ERK5_b

Species: S.moellendorffii
Alias: ERK5_b
External Links:
Annotation:

Classification

Group: CMGC
Family: MAPK
Subfamily: ERK1

Sequence

Name Sequence Type Origin Length Description Download
ERK5_b.AA Protein None 508 None Fasta, JSON
ERK5_b.NA RNA None 1527 None Fasta, JSON
ERK5_b.kin_dom Protein Kinase Domain None 311 None Fasta, JSON

Protein domain

Protein domains of ERK5_b.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase ERK5_b.AA MAPK 17-301 46 1.3e-152 513.25 In-house 1-321 (328) Show / Hide 
Range on Protein: 17-301
Range on HMM: 1-321/328
Sequence Identity: 46% (150 aa)

YKVLEVIGKGSYGVVCSAIDTR------TNEKVAIKKINDIFEHVSDATRILREIKLLRLL-RHPDVVEIKHILLP------PSRREFKDIYVVFELMES
|. |. ||.|.|||||||||.|      ...||||||| . |... .. |..||||||| . .|. .. ...|. |      .|. ||.|||.|.||||.
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

DLHQVIKANDDLMPEHYQFFLYQLLRG--LKFIHTANVFHRDLKPKNVLANANCKLKICDFGLARVAFND------------APTAIFWTDYVATRWYRA
||||.|| .. |  .| |.|.||.|||  ||.|| ||| |||||| |.| | || ||||||||||.. ..            .  . . |.|||||||||
DLHQIIKSQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCF-QKMHMTEYVATRWYRA

PELCGSF-FSRYTPAIDIWSIGCIFAETIT-RKPLFPGKNVTHQLELITDLLGTPSQDVISRVR-NEKARRYLSTM---SKKSPVPFSEKFKN----IDP
||.  .    .|| |.|.||.|||||| .| ||||||||.  .|..||...|||||...|...  .|.|| |.. .    |. ..|... |.|     .|
PEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANP

LARNLLQKMLAFDPKDRPSATE
.|..||.|||.|||..| .. |
QAIDLLEKMLVFDPDKRITVEE
Kinase ERK5_b.AA ERK 17-296 48 5.9e-149 501.15 In-house 1-295 (307) Show / Hide 
Range on Protein: 17-296
Range on HMM: 1-295/307
Sequence Identity: 48% (145 aa)

YKVLEVIGKGSYGVVCSAIDTR-----TNEKVAIKKINDIFEHVSDATRILREIKLLRLLR-HPDVVEIKHILLPPSRREFKDIYVVFELMESDLHQVIK
|. .. ||.|.|||||||||.      |..||||||| ..|.|  ...|.||||||||... |. .. ...|..| |. ...|||.|.||||.||||.|.
YQIIKQIGHGAYGVVCSAIDKEYCFDETGQKVAIKKIENAFDHPIYCKRTLREIKLLRHFKGHENIICLFDIMMPNSPEQYNDIYCVEELMETDLHQIIN

ANDDLMPEHYQFFLYQLLRGLKFIHTANVFHRDLKPKNVLANANCKLKICDFGLAR---VAFNDAP--TAIFWTDYVATRWYRAPELCGSFFSRYTPAID
    | ..|.|.|.||.|.|||.|| |||.||||||.|.| | || ||||||||||   . ... .  .. | |.|||||||||||.  | .. || |.|
SQQELSDDHCQYFMYQILCGLKYIHSANVIHRDLKPSNILVNSNCDLKICDFGLARCFDASYQENHECNQNFMTEYVATRWYRAPEIMLS-WQKYTKAMD

IWSIGCIFAETITRKPLFPGKNVTHQLELITDLLGTP-SQDVISRVRNEKARRYLSTMSK--KSPVPFSEKFKN--IDPLARNLLQKMLAFDPKDR
|||.|||||| . ||||||||.  ||...|....||| |.. ...  .|.|. |.. ...  . |.|... |.|  . |.| .||.|||.|||..|
IWSCGCIFAEMLGRKPLFPGKDYVHQINRIFQIIGTPHSEEDLQYICSENAWKYIKNLPNPVRPPKPWENIFPNANCNPQAIDLLEKMLVFDPDKR
Kinase ERK5_b.AA ERK5 17-299 48 2.3e-119 402.88 In-house 1-286 (295) Show / Hide 
Range on Protein: 17-299
Range on HMM: 1-286/295
Sequence Identity: 48% (140 aa)

YKVLEVIGKGSYGVVCSAIDTRTNEKVAIKKINDIFEHVSDATRILREIKLLRLLRHPDVVEIKHILLPPS-RREFKDIYVVFELMESDLHQVIKANDDL
||..| || | |||||||.  .. ..||||||   |. |  | | .||.|.||  ||  .. |. || |     |.||.||||.||||||||.| .|  .
YKIIEKIGNGAYGVVCSARRRKNGQQVAIKKIPNAFDVVTNAKRTFRELKILRHFRHDNIIAIRDILMPKVPYSEMKDVYVVFDLMESDLHQIIHSNQPF

MPEHYQFFLYQLLRGLKFIHTANVFHRDLKPKNVLANANCKLKICDFGLAR--VAFNDAPTAIFWTDYVATRWYRAPELCGSFFSRYTPAIDIWSIGCIF
  ||  .||||.|||||..| |.| |||||| |.| | || ||| |||.||    |  .   .| |.||||||||||||  |    || |||.||.||||
TLEHIRYFLYQILRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTFSPDKHQMFMTEYVATRWYRAPELMFS-SHDYTQAIDVWSVGCIF

AETITRKPLFPGKNVTHQLELITDLLGTPSQDVISRVRNEKARRYLST-MSKKSPVPFSEKFKNIDPLARNLLQKMLAFDPKDRPSA
 | |.|. .|||||  |||.|| . ||.|.  .|  |  .. . |.   .. . |..... .   |. | .|| .|| |.| .| ..
GEMIARRQMFPGKNYIHQLQLIMMVLGMPPPHMIQAVSADHVYNYFQKNFPNRQPKDWEKVYPKADRQALDLLARMLRFEPSERITV
Kinase ERK5_b.AA CMGC 17-301 26 2.4e-119 394.07 In-house 1-506 (513) Show / Hide 
Range on Protein: 17-301
Range on HMM: 1-506/513
Sequence Identity: 26% (135 aa)

YKVLEVIGKGSYGVVCSAIDTRTN--------------EKVAIKKINDIFEHVSDAT----------RILREIKLLRLLR----------------HPD-
|.....||.|.||||....|.|||              |.||||||   | .  .|           |.|||||.|. |.                |.  
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

VVEIKHILLPP-SRRE-----------FKDIYVVFELMESDLHQVIKAND---------DLMPEH------------YQFFL------YQLLRGLK--FI
.| .. |. .. |...           |...| |||.|. ||.|.|| |           | . |             ..|.      ||.|||||  ..
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HTAN--VFHRDLKPKNVLANANCKL--------------------KICDFGLAR-VAFNDAPTAI-----------------FWTDYVATRWYRAPE-LC
| ..  ..|||||| |.| | ||.|                    ||||||||| .  .. ...                  . |.||.|||||||| |.
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILL

GS-------FFSRYTPAIDIWSIGCIFAETITR--------KPLFPGKNV-----------THQLELITDLLGTP----------------SQDVISRVR
|.       ..  ||..||.||.|||||| .|.        ||||||..             .||..| ..||||                ... .... 
GWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIK

--------------------NEKARRYLST---MSKKSPVPFSEKFKN-----------------------------------IDPLARNLLQKMLAFDP
                    .|.||.|..      .. | |....|..                                   .||.|..||.||| .||
LPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDP

KDRPSATE
..|..| .
DKRITAEQ
Kinase ERK5_b.AA p38 17-301 42 4.1e-110 372.11 In-house 1-282 (289) Show / Hide 
Range on Protein: 17-301
Range on HMM: 1-282/289
Sequence Identity: 42% (122 aa)

YKVLEVIGKGSYGVVCSAIDTRTNEK---VAIKKINDIFEHVSDATRILREIKLLRLLRHPDVVEIKHILLP--PSRREFKDIYVVFELMESDLHQVIKA
|. |. .|.|.|| ||.|.|.||..|   |||||..  |. . .| |. ||..||...||  |...  .  |   |...|.|.|.| ..|..||....| 
YQNLQPVGSGAYGQVCKAEDRRTGQKRRYVAIKKLMRPFQSEIHAKRTYRELRLLKHMRHENVICLLDVFTPPAHSMNDFQDVYMVTHFMGADLNNIMKC

NDDLMPEHYQFFLYQLLRGLKFIHTANVFHRDLKPKNVLANANCKLKICDFGLARVAFNDAPTAIFWTDYVATRWYRAPELCGSFFSRYTPAIDIWSIGC
   |  .| || .||.|||||.|| |.. |||||| |.  | .| |.| ||||||      ...   |.|||||||||||   .    || ..||||.||
QR-LSDDHIQFLVYQILRGLKYIHSAGIIHRDLKPSNIAVNEDCELRILDFGLAR------HCDDEMTGYVATRWYRAPEIMLNWMH-YTQTVDIWSVGC

IFAETITRKPLFPGKNVTHQLELITDLLGTPSQDVISRVRNEKARRYLSTMSKKSPVPFSEKFKNIDPLARNLLQKMLAFDPKDRPSATE
| || ||...||||..  .||. |. ..|||.. ..... .|.|| |.  ...     |.. |.. .|.| .|| |||  ||  | .| |
IMAELITGRTLFPGDDHIDQLQRIMKVCGTPDEEFWQKIQSEEARNYIQSYPQMPRRDFHHVFMGANPQAIDLLEKMLELDPDKRITAEE
Kinase ERK5_b.AA ERK1 17-296 49 2.1e-105 356.45 In-house 1-277 (289) Show / Hide 
Range on Protein: 17-296
Range on HMM: 1-277/289
Sequence Identity: 49% (139 aa)

YKVLEVIGKGSYGVVCSAIDTRTNEKVAIKKINDIFEHVSDATRILREIKLLRLLRHPDVVEIKHILLPPSRREFKDIYVVFELMESDLHQVIKANDDLM
|  |. ||.| ||.||||.||.....||||||   |||     | |||||.|   .|  ...|. |.  ..  ...|.|.| .||| || ...|.   | 
YTNLQYIGEGAYGMVCSAYDTVHKQRVAIKKIS-PFEHQTYCQRTLREIKILTRFKHENIINIQDIIRADTIEQMRDVYIVQCLMETDLYKLLKT-QHLS

PEHYQFFLYQLLRGLKFIHTANVFHRDLKPKNVLANANCKLKICDFGLARVAFNDAPTAIFWTDYVATRWYRAPELCGSFFSR-YTPAIDIWSIGCIFAE
 .|  .||||.|||||.|| ||| |||||| |.| |  | ||||||||||.|  .     | |.|||||||||||.     |. || .|||||.||| ||
NDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIM--LNSKGYTKSIDIWSVGCILAE

TITRKPLFPGKNVTHQLELITDLLGTPSQDVISRVRNEKARRYLSTMSKKSPVPFSEKFKNIDPLARNLLQKMLAFDPKDR
 .  .|.||||    || .|  .|| |||| .  . ||||| ||  .  |. ||. . | . |. |  ||.|||.| |. |
MLSNRPIFPGKHYLDQLNHILGVLGSPSQDDLNCIINEKARNYLQSLPHKPKVPWARLFPKADSKALDLLDKMLTFNPHKR
Kinase ERK5_b.AA ERK7 17-301 41 1.4e-95 323.83 In-house 1-285 (292) Show / Hide 
Range on Protein: 17-301
Range on HMM: 1-285/292
Sequence Identity: 41% (119 aa)

YKVLEVIGKGSYGVVCSAIDTRTNEKVAIKKINDIFEHVSDATRILREIKLLRLLR-HPDVVEIKHILLPPSRREFKDIYVVFELMESDLHQVIKANDDL
|.... .||| ||.|  |.| || . ||.||| | |    || |  ||| .|. .. || .. .  ..        .|||.||| ||.||| ||.  . |
YEIRKRLGKGAYGIVWKAYDKRTKQVVALKKIFDAFRNQTDAQRTFREIMFLQEFHCHPNIIRLINVI---RADNDRDIYLVFEFMETDLHAVIRKGNIL

MPEHYQFFLYQLLRGLKFIHTANVFHRDLKPKNVLANANCKLKICDFGLAR-VAFND--APTAIFWTDYVATRWYRAPE-LCGSFFSRYTPAIDIWSIGC
   | |. .||||| .|..| .|| |||||| |.| ...| .|.||||||| .|  .  ..     |.||||||||||| | ||   |||...| |||||
KDIHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGS--HRYTKGVDMWSIGC

IFAETITRKPLFPGKNVTHQLELITDLLGTPSQDVISRVRNEKARRYLSTMSKKSPVPFSEKFKNIDPLARNLLQKMLAFDPKDRPSATE
| .| .. ||.|||    .|.|.| .... |.|  |  .  . |   |. | .. . .... ...  . | .||...|.| || | .|..
ILGEMLRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMPQCCDDAIDLLKRLLVFNPKKRLTAEQ
Kinase ERK5_b.AA nmo 18-301 43 1.4e-92 285.02 In-house 2-285 (292) Show / Hide 
Range on Protein: 18-301
Range on HMM: 2-285/292
Sequence Identity: 43% (125 aa)

KVLEVIGKGSYGVVCSAIDTRTNEKVAIKKINDIFEHVSDATRILREIKLLRLLRHPDVVEIKHILLPPSRREFKDIYVVFELMESDLHQVIKANDDLMP
.    || | .||| |  | |   .||.||. ..|  .  . |. ||.|.|   .|  |.  . || ||    |..|||| ||| ||||..| .   | .
QPDRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDILQPPHKDFFQEIYVVTELMQSDLHKIIVSPQHLSS

EHYQFFLYQLLRGLKFIHTANVFHRDLKPKNVLANANCKLKICDFGLARVAFNDAPTAIFWTDYVATRWYRAPE-LCGSFFSRYTPAIDIWSIGCIFAET
.| . ||||.|||||..|.||. |||.|| |.| |.|| |||||||||||   .  ..   |  | | .||||| | |.   .|| |.||||.|||||| 
DHVKVFLYQILRGLKYLHSANILHRDIKPGNLLVNSNCVLKICDFGLARVW--EQDQSKHMTQEVVTQYYRAPEILMGA--RHYTSAVDIWSVGCIFAEL

ITRKPLFPGKNVTHQLELITDLLGTPSQDVISRVRNEKARRYLSTMSKKSPVPFSEKFKNID-----PLARNLLQKMLAFDPKDRPSATE
. |. ||  ..  .||..|||||||||.. . .   | |.  .  |..| |  ..  ..          | .||..|| |||  | |...
LGRRILFQAQSPIQQLQMITDLLGTPSMEDM-KYACEGAKAHMLRMPHKPPC-LQVLYTLSSPDHATHEAVHLLCRMLHFDPDKRISCKD
Kinase ERK5_b.AA S_TKc 17-311 26 2.8e-86 293.87 SMART 1-231 (231) Show / Hide 
Range on Protein: 17-311
Range on HMM: 1-231/231
Sequence Identity: 26% (82 aa)

YKVLEVIGKGSYGVVCSAIDTRTNEKVAIKKINDIFEHVSDATRILREIKLLRLLRHPDVVEIKHILLPPSRREFKDIYVVFELMES---DLHQVIKAND
|..|..||||..|.|. .....|...||||.|.          .|.|||..|.  .|| .| .. .         ...|.|.|...    ||...|| . 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD------DHLYMVMEYCDGDLGDLFDYIKKRG

D------LMPEHYQFFLYQLLRGLKFIHTANVFHRDLKPKNVLANANCKLKICDFGLARVAFNDAPTAIFWTDYVATRWYRAPELCGSFFSRYTP-AIDI
       . . | .|..||....|...|  .. |||||| |.| .    .|||||||||.           | .. |.||.|||..      |.. ..|.
RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMAPEVL-----GYGKCKCDW

WSIGCIFAETITRKPLFPGKNVTHQLELITDLLGTPSQDVISRVRNEKARRYLSTMSKKSPVPFSEKFKNIDPLARNLLQKMLAFDPKDRPSATEVKY--
||.|||..| ....|.||      |.... ...|                                     .| |.....|.| .||..||.| |.    
WSCGCILYEMLCGYPPFP------QMQMMFKKIG-------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDE

--SLTSEQV
      . .
WDIKCHPWF
Kinase ERK5_b.AA CDK 17-301 34 3.3e-86 275.8 In-house 1-277 (284) Show / Hide 
Range on Protein: 17-301
Range on HMM: 1-277/284
Sequence Identity: 34% (112 aa)

YKVLEVIGKGSYGVVCSAIDTRTN-----EKVAIKKINDIF---EHVSDATRI--LREIKLLRLLRHPDVVEIKHILLPP-----SRREF--KDIYVVFE
|. || || |.||||  |.|..|.     . ||.|||       |   .   |  .|||.||. | || .| .. . .         . .  . .| |||
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNN-KDKHENKLYMVFE

LMESDLHQVIKANDDLMPEHYQFFLYQLLRGLKFIHTANVFHRDLKPKNVLANANCK-----LKICDFGLARVAFNDA-----PTAIFWTDYVATRWYRA
 |. || ....          . ...|||||| ..|  .. |||||| | | | | .     ||| |||||| ||.       |.  . |  | |.||||
YMDHDLKKYMD---------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLAR-AFGIPHQMSEPNRTY-THEVVTLWYRA

PELCGSFF--SRYT--PAIDIWSIGCIFAETIT---RKPLFPGKNVTHQLELITDLLGTPSQDV---ISRVRNEKARRYLSTMSKKSPVPFSEKFKNIDP
|||    .  ..|.  ..||.||.|||||| .|   |||||||.. ..||..| ...|||. |.   ..   .                           
PEL---LLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY--------------------------

LARNLLQKMLAFDPKDRPSATE
   .||.|||..||| | ||..
---DLLNKMLCYDPKKRISAEQ
Kinase ERK5_b.AA MAPK-Unclassified 17-166 46 6.5e-75 255.19 In-house 1-157 (575) Show / Hide 
Range on Protein: 17-166
Range on HMM: 1-157/575
Sequence Identity: 46% (73 aa)

YKVLEVIGKGSYGVVCSAIDTRT-NEKVAIKKINDIFEHVSDATRILREIKLLRLLRHPDVVEIKHILLPPSRRE--FKDIYVVFELMES---DLHQVIK
| . ..|| |.||.|| |.|... | .|||||.| ||. ..|. |.|||| .|| | || .. |. |. . .     |.|||.| ..|..   ||||.||
YEYQKNIGSGAYGQVCRAMDKKNQNQQVAIKKVNHIFHNHTDCKRVLREIRILRYLNHPNIIQIQDIFYNKELHNQEFDDIYIVMDYMQTSLFDLHQIIK

AND-DLMPEHYQFFLYQLLRGLKFIHTANVFHRDLKPKNVLANANCKLKICDFGLAR
 |   .. .| | |.||.||||| .| |.. |||||| |.|.| .| ..|||||..|
SNQDHWCHQHIQYFFYQILRGLKYLHSACIIHRDLKPSNLLINQDCSVRICDFGMSR
Kinase ERK5_b.AA Pkinase 17-306 27 1.5e-74 258.78 Pfam 1-293 (293) Show / Hide 
Range on Protein: 17-306
Range on HMM: 1-293/293
Sequence Identity: 27% (86 aa)

YKVLEVIGKGSYGVVCSAIDTRTNEKVAIKKINDIFEHVSDATRILR--EIKLLRLLRHPDVVEIKHILLPPSRREFKDIYVVFELMES-----DLHQVI
|.....||.||.|.|. ...  |...||.|.|.   |. .   . .|  ||.... |.|| .|.....         ..||.|.|..|      ||. .|
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-----KDHIYMVMEYCEGGLYVMDLFDYI

K--ANDDL--MPEHYQFFLYQLLRGLKFIHTANVFHRDLKPKNVLANANCKL----KICDFGLARVAFNDAPTAIFWTDYVATRWYRAPELCGSFFSRYT
.  ..  .   ... .|..||.||||...|  .. |||||| |.| . |. .    ||||||||...          |... |.||.|||..  . . |.
STWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIR-GGQYYG

PAIDIWSIGCIFAETITRKPLFPGK----NVTHQLELITDLLGTPSQDVISRVRNEKARRYLSTMSKKSPVPFSEKFKNIDPLARNLLQKMLAFDPKDRP
|..|.||.|||..| ....|.|||.    |   |...|   .|.|    ..  ...  .  ...   .    .... .|... .. .. ..|..|||.||
PKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H--F-HWTF-HNWSEECKDFIKWCLCKDPKKRP

SATEVKYS--L
.|.... .  .
TAEQILQHPWF
Kinase ERK5_b.AA MAPK-Unclassified 179-299 31 2.4e-39 137.06 In-house 406-566 (575) Show / Hide 
Range on Protein: 179-299
Range on HMM: 406-566/575
Sequence Identity: 31% (51 aa)

TDYVATRWYRAPELCGSFFSRYTPAIDIWSIGCIFAETITR-----------KPLFPGKN--------------------VTHQLELITDLLGTPSQDVI
| ||.||||||||.  |  . |. ..||||||||||| . .           .|||||..                    .  |. .| | ||.| . ..
TQYVVTRWYRAPEIMLS-MHEYDTQVDIWSIGCIFAEMMQMYDRHNPTFSDHRPLFPGQDCFPITPDRNNDVDQGGFPHSHQDQIKMIFDYLGMPPEEDC

SRVRNEKARRYLSTMSKKSPVPFS-EKFKNID---------PLARNLLQKMLAFDPKDRPSA
..... .|| |...  .| ||.|.   | .           .......||||.|.|. | .|
NFITCDSARKYIQSFKCKTPVHFTDLMFCKAPGDDQIVRGNCECIDFVQKMLQFNPWKRITA
Kinase ERK5_b.AA TyrKc 17-306 20 2e-16 42.96 SMART 1-280 (280) Show / Hide 
Range on Protein: 17-306
Range on HMM: 1-280/280
Sequence Identity: 20% (65 aa)

YKVLEVIGKGSYGVVCSAIDTRTNEKVAIKKINDIFEHVSDATRILREIKLLRLL--RHPDVVEIKHILLPPSRREF---KDIYVVFELMES-DLHQVIK
 . ....| | .|.|. .. .   ..||.|....          ..||..... |  .|| .| .  . . ..|. |   . ...|.|.|.  ||.. ..
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN-FMYIEPLMIVMEYMPHGDLKDYLR

ANDD-LMPEHYQFFLYQLLRGLKFIHTANVFHRDLKPKNVLANANCKLKICDFGLARVAFND------APTAIF----WTDY-VATRWYRAPELCGSFFS
.. . | ...   | .|  .|  ..|  |. ||||   |.| ..|   ||.||||.|   .|        .        ... .  ||. |||    ...
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APECI--NYG

RYTPAIDIWSIGCIFAETITR-KPLFPG-----KNVTHQLELITDLLGTPSQDV---ISRVRNEKARRYLSTMSKKSPVPFSEKFKNIDPLARNLLQKML
..|.. |.|| |    |  |. ..  ||     .. .. .|.. .    |  .    .|                         |    .   .. ..  
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS-------------------------FVCCPDEMYQIMKQCW

AFDPKDRPSATEVKYSL
..||.|||. .|..  .
HEDPEDRPTFSEIHECF
Kinase ERK5_b.AA Pkinase_Tyr 17-171 26 1.1e-14 50.39 Pfam 1-164 (270) Show / Hide 
Range on Protein: 17-171
Range on HMM: 1-164/270
Sequence Identity: 26% (44 aa)

YKVLEVIGKGSYGVVCSAIDT----RTNEKVAIKKINDIFEHVSDA---TRILREIKLLRLL-RHPDVVEIKHILLPPSRREFKDIYVVFELMES-DLHQ
 . ....|.|..|.|. .. .     |. .||.|....   . ...      .||.|... | .|| .|    . .. ..     ||.|.|.|.  ||. 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE--GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN--QIYIVMEYMPHGDLLD

VIKA----NDDLMPEHYQFFLYQLLRGLKFIHTANVFHRDLKPKNVLANANCKLKICDFGLARVAFND
  ..    .. | ...   . .|  .|. . .  |  ||||  .|.| . | . |||||||||  .||
YLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYND
Kinase ERK5_b.AA CMGC 320-327 75 0.12204 0.11 In-house 506-513 (513) Show / Hide 
Range on Protein: 320-327
Range on HMM: 506-513/513
Sequence Identity: 75% (6 aa)

QALADPYF
|||. |||
QALQHPYF