Gene ERK-Un (S.moellendorffii)
ERK-Un
Species: S.moellendorffii
Alias: ERK-Un
External Links:
Annotation:
Sequence
Protein domains of ERK-Un.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| S_TKc | ERK-Un.AA | S_TKc | 93-367 | 26 | 4.3e-73 | 250.05 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 93-367
Range on HMM: 1-231/231
Sequence Identity: 26% (78 aa)
YLLHEHIGSGSYGDVCRATDCQASLTVALKRVGDVLCCPLLAKRVLREVCIMRRLSHRYVITLTDVFISMSMEVSGGIDLYIATEFADG--GDMYHLREP
| ....||.|..| |..... ||.|.. ....||. |... | ....| ||| . .||. .|..|| ||.... .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD--------DHLYMVMEYCDGDLGDLFDYIKK
---------LTPEHVKFLMWQLLTGMSYIHSCRVWHRDLKSENILLMADMSVKICDFGLSRSA-EEVVTPSYRAPEVIMSRGQYSS-SIDIWSLGCIFWV
... |..|.|.|.. .. |.|| .. ||||| ||||| .|||||||.| ..|| |.||||. .|. ..|.||.|||..
RGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQLTTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYE
SVS-----SNDITILNLDVIFNVIGTPGWSDIESVPSESWRSYLKHLPGRVRNLTEQLLGYVDQEALDLLFRMLAFNPGRRCTAEEALS-------HIYV
.. . .....|..|| ..||.|.. ..| ..| .| || ||| | ..
MLCGYPPFP------QMQMMFKKIG-------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Pkinase | ERK-Un.AA | Pkinase | 93-367 | 26 | 4.1e-68 | 237.38 | Pfam | 1-293 (293) | Show / Hide |
Range on Protein: 93-367
Range on HMM: 1-293/293
Sequence Identity: 26% (83 aa)
YLLHEHIGSGSYGDVCRATDCQASLTVALKRVGDVLCCPLLAKRVLR--EVCIMRRLSHRYVITLTDVFISMSMEVSGGIDLYIATEFADGG----DMY-
| ... |||||.| |..... . .||.|.. . . .. .| |..||.||.| ....| |.| . . ..|. .|...|| | .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-------KDHIYMVMEYCEGGLYVMDLFD
----HLREPL--TPEHVKFLMWQLLTGMSYIHSCRVWHRDLKSENILLMADMSV----KICDFGLSRSA-------EEVVTPSYRAPEVIMSRGQYSSSI
. . .. .....|| |.|.| |. |.||... |||||.||||. .. . |||||||.. . ..|| |.|||||... |....
YISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDYNNSMTTFCGTPWYMAPEVIRGGQYYGPKV
DIWSLGCIFWVSVS-----SND----ITILNLDVIFNVIGTPGWSDIESVPSESWRSYLKHLPGRVRNLTEQLLGYVDQEALDLLFRMLAFNPGRRCTAE
|.||.|||.. .. ... . . .|... |.| .|.. |.|... ..| . . .. . ....|..|.. ..|...| .|.|||
DMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H--F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAE
EALSHIYV
..| | ..
QILQHPWF
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| Kinase | ERK-Un.AA | CMGC | 93-277 | 22 | 2.2e-58 | 190.06 | In-house | 1-325 (513) | Show / Hide |
Range on Protein: 93-277 Range on HMM: 1-325/513 Sequence Identity: 22% (72 aa) YLLHEHIGSGSYGDVCRATD--------------CQASLTVALKRVGDVLCCPLLAK----------RVLREVCIMRRLS-----------------HRY | . ||.|.|| |....| .. ||.|.. . . || | |||. |...|. | . YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN VITLTDVFISMSMEVSGGI----------DLYIATEFADGGDMYHLRE-----------PLTPEH------------VKFLM------WQLLTGMS--YI ...| |.| . .. .. .||. .|. | ... ||.. | .|..| .|.|.|. |. IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC HSCR--VWHRDLKSENILLMAD--------------------MSVKICDFGLSR-----------------------------SAEEVVTPSYRAPEVIM || . . ||||| ||||. . . .|||||||.| ..||| |||||... HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILL SRGQYS---------SSIDIWSLGCIF . ..|. ..||.||.|||| GWKHYTNHNYSMHYTTPIDMWSVGCIF |
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| Kinase | ERK-Un.AA | MAPK | 93-277 | 33 | 2.5e-55 | 189.77 | In-house | 1-224 (328) | Show / Hide |
Range on Protein: 93-277 Range on HMM: 1-224/328 Sequence Identity: 33% (75 aa) YLLHEHIGSGSYGDVCRATDCQ------ASLTVALKRVGDVLCCPLLAKRVLREVCIMRRL-SHRYVITLTDVFIS-MSME--VSGG--IDLYIATEFAD | . . ||.|.|| || |.| .||.|.. .. |...||..||. ..|.. | .| | |.| |. . | . |.|| .|. . YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQ-DDQNSLEEFNDIYIVMELME GGDMYHLRE---PLTPEHVKFLMWQLLTG--MSYIHSCRVWHRDLKSENILLMADMSVKICDFGLSRSAEE----------------------VVTPSYR |.... . ||. .|....|.|.| | . |||| .| ||||| .|||. . .|||||||.||.. |.| || -TDLHQIIKSQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYR APEVIMSR--GQYSSSIDIWSLGCIF |||..... |. ..|.||.|||| APEIMLNWIWMHYTKAVDMWSVGCIF |
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| Kinase | ERK-Un.AA | ERK7 | 93-367 | 33 | 3e-55 | 187.27 | In-house | 1-292 (292) | Show / Hide |
Range on Protein: 93-367 Range on HMM: 1-292/292 Sequence Identity: 33% (99 aa) YLLHEHIGSGSYGDVCRATDCQASLTVALKRVGDVLCCPLLAKRVLREVCIMRRLS-HRYVITLTDVFISMSMEVSGGIDLYIATEFADGGDMYHLR--E |.... .| | || | .|.| .. .||||.. | . | | ||. ... . | .| | .|. . |.|.. || . | . YEIRKRLGKGAYGIVWKAYDKRTKQVVALKKIFDAFRNQTDAQRTFREIMFLQEFHCHPNIIRLINVI-----RADNDRDIYLVFEFMETDLHAVIRKGN PLTPEHVKFLMWQLLTGMSYIHSCRVWHRDLKSENILLMADMSVKICDFGLSRS---AEE-----------VVTPSYRAPEVIMSRGQYSSSIDIWSLGC | |... |.||| . |.|| .| ||||| |||| .. ||.||||| || || | | |||||. .. .| .| ||.|| ILKDIHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMWSIGC IFWVSVSSNDI-----TILNLDVIFNVIGTPGWSDIESVPSESWRSYLKHLPGRVRNLTEQLLGYVDQEALDLLFRMLAFNPGRRCTAEEALSHIYV | . . |. .. | ..|. | |||.. |. . |.... . | .|.. ..|.||| |.|.||| .| |||.||.| || ILGEMLRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMPQCCDDAIDLLKRLLVFNPKKRLTAEQALQHPYV |
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| Kinase | ERK-Un.AA | ERK1 | 93-367 | 36 | 1.3e-52 | 181.07 | In-house | 1-289 (289) | Show / Hide |
Range on Protein: 93-367 Range on HMM: 1-289/289 Sequence Identity: 36% (108 aa) YLLHEHIGSGSYGDVCRATDCQASLTVALKRVGDVLCCPLLAKRVLREVCIMRRLSHRYVITLTDVFISMSMEVSGGIDLYIATEFADGGDMYHL--REP |. . || | || || | | ||.|.. .| |||. |. | | .| . |. . ..| |.|| . . |.| | . YTNLQYIGEGAYGMVCSAYDTVHKQRVAIKKIS-PFEHQTYCQRTLREIKILTRFKHENIINIQDIIRADTIEQM--RDVYIVQCLME-TDLYKLLKTQH LTPEHVKFLMWQLLTGMSYIHSCRVWHRDLKSENILLMADMSVKICDFGLSRSA-----------EEVVTPSYRAPEVIMSRGQYSSSIDIWSLGCIFWV | .|. . ..|.| |. |||| | ||||| |.|| .||||||| | | | | | |||||... | |||||| ||| LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAE SVSSNDIT-----ILNLDVIFNVIGTPGWSDIESVPSESWRSYLKHLPGRVRNLTEQLLGYVDQEALDLLFRMLAFNPGRRCTAEEALSHIYV .| | . | | |.| | |.. . | |.||. || . . ..| |. ||||| .||.||| .| | |||| | |. MLSNRPIFPGKHYLDQLNHILGVLGSPSQDDLNCIINEKARNYLQSLPHKPKVPWARLFPKADSKALDLLDKMLTFNPHKRITVEEALAHPYL |
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| Kinase | ERK-Un.AA | ERK5 | 93-367 | 33 | 2.2e-49 | 170.37 | In-house | 1-295 (295) | Show / Hide |
Range on Protein: 93-367 Range on HMM: 1-295/295 Sequence Identity: 33% (98 aa) YLLHEHIGSGSYGDVCRATDCQASLTVALKRVGDVLCCPLLAKRVLREVCIMRRLSHRYVITLTDVFISMSMEVSGGIDLYIATEF--ADGGDMYHLREP | |.|| | || || | . ||.|.. ||| .||. |.| | .| . |. | | |. . .| . | | YKIIEKIGNGAYGVVCSARRRKNGQQVAIKKIPNAFDVVTNAKRTFRELKILRHFRHDNIIAIRDILMPK-VPYSEMKDVYVVFDLMESDLHQIIHSNQP LTPEHVKFLMWQLLTGMSYIHSCRVWHRDLKSENILLMADMSVKICDFGLSR--SA-----------EEVVTPSYRAPEVIMSRGQYSSSIDIWSLGCIF .| ||... ..|.| |. |.|| | ||||| |.| .|| |||. | . | | | |||||...| .| ||.|| |||| FTLEHIRYFLYQILRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTFSPDKHQMFMTEYVATRWYRAPELMFSSHDYTQAIDVWSVGCIF WVSVSSNDI-----TILNLDVIFNVIGTPGWSDIESVPSESWRSYLKH-LPGRVRNLTEQLLGYVDQEALDLLFRMLAFNPGRRCTAEEALSHIYV .. . | |..| |.|.| |..| .. . |... .| | |.. |. ||||| ||| | | | |. .|| | .. GEMIARRQMFPGKNYIHQLQLIMMVLGMPPPHMIQAVSADHVYNYFQKNFPNRQPKDWEKVYPKADRQALDLLARMLRFEPSERITVNKALQHPFL |
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| Kinase | ERK-Un.AA | CAMK | 98-276 | 18 | 3.4e-47 | 149.71 | In-house | 1-323 (425) | Show / Hide |
Range on Protein: 98-276
Range on HMM: 1-323/425
Sequence Identity: 18% (61 aa)
HIGSGSYGDVCRATDCQAS------------LTVALKR-------------------VGDVLCC-------PLLAKRVLREVCIMRRLS-------HRYV
.|.||.| | .... . || | . . |. | |.|.||..||..|. |. .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI
ITLTDVFISMSM--------EVSG-----GIDLYIAT---EFADGG----D-MYHLREP-----------------LTPEHVKFLMWQLLTGMSYIHSCR
| | .|. ... | ..|. . |...|| | ...| .| . ......|.. .. |.||.
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN
VWHRDLKSENILLMADM-----------------SVKICDFGLSRSAEEVV-------------------------------TPSYRA-PEVIMS-----
. ||||| ||||| .. .||.|||... .. ||.| | |||. .
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN
--------RGQYSSSIDIWSLGCI
. |. ..|.||.|.|
MQNATDEEKPYYGPKCDMWSCGVI
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| Kinase | ERK-Un.AA | p38 | 93-276 | 35 | 2.1e-45 | 153.04 | In-house | 1-193 (289) | Show / Hide |
Range on Protein: 93-276 Range on HMM: 1-193/289 Sequence Identity: 35% (69 aa) YLLHEHIGSGSYGDVCRATDCQASLT---VALKRVGDVLCCPLLAKRVLREVCIMRRLSHRYVITLTDVFISMSMEVSGGIDLYIATEFADGGDMYHLRE | ...|||.|| || | | . . || |. .. ||| ||. . . |. || | ||| ... | |. |.|.. .. YQNLQPVGSGAYGQVCKAEDRRTGQKRRYVAIKKLMRPFQSEIHAKRTYRELRLLKHMRHENVICLLDVFTPPAHSMNDFQDVYMVTHFMGADLNNIMKC P-LTPEHVKFLMWQLLTGMSYIHSCRVWHRDLKSENILLMADMSVKICDFGLSRSAEE-----VVTPSYRAPEVIMSRGQYSSSIDIWSLGCI |. .|..|| |.| | |||| . ||||| || . | ..| ||||.|.... |.| |||||.. ....| .||||.||| QRLSDDHIQFLVYQILRGLKYIHSAGIIHRDLKPSNIAVNEDCELRILDFGLARHCDDEMTGYVATRWYRAPEIMLNWMHYTQTVDIWSVGCI |
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| Kinase | ERK-Un.AA | MAPK-Unclassified | 93-246 | 36 | 1e-42 | 148.25 | In-house | 1-161 (575) | Show / Hide |
Range on Protein: 93-246 Range on HMM: 1-161/575 Sequence Identity: 36% (59 aa) YLLHEHIGSGSYGDVCRATDCQA-SLTVALKRVGDVLCCPLLAKRVLREVCIMRRLSHRYVITLTDVFISMSMEVSG--GIDLYIATEFADG-----GDM |.. . ||||.|| ||||.| . || |.| . . ..||||||. | | |.| .| ..|.| . | .. .|.|| ... YEYQKNIGSGAYGQVCRAMDKKNQNQQVAIKKVNHIFHNHTDCKRVLREIRILRYLNHPNIIQIQDIF--YNKELHNQEFDDIYIVMDYMQTSLFDLHQI YHLRE-PLTPEHVKFLMWQLLTGMSYIHSCRVWHRDLKSENILLMADMSVKICDFGLSRSAEE .. .. .. .|.. .. |.|.|. |.|| . ||||| |.|. | ||.|||||.||| |. IKSNQDHWCHQHIQYFFYQILRGLKYLHSACIIHRDLKPSNLLINQDCSVRICDFGMSRSIED |
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| Kinase | ERK-Un.AA | CDK | 138-277 | 34 | 6.4e-42 | 131.79 | In-house | 56-212 (284) | Show / Hide |
Range on Protein: 138-277
Range on HMM: 56-212/284
Sequence Identity: 34% (58 aa)
LREVCIMRRLSHRYVITLTDVFISMSMEVSGGID-----LYIATEFADGGDMYHLREPLTPEHVKFLMWQLLTGMSYIHSCRVWHRDLKSENILLMADMS
.||..... | | ....| ||.....|. .. .| ||. |..| | ... . .| .||||| |..|.|| .. ||||| |||.. . .
IREISLLKEL-HPNIVKLHDVCHTKNMDRNN-KDKHENKLYMVFEYMDH-DLKKYMD------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGE
-----VKICDFGLSRSAE--------------EVVTPSYRAPEVIMSRGQYS--SSIDIWSLGCIF
.|| ||||.| |||| |||||. . .|| .||.||.||||
VKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPELLLGSKHYSGGTPIDMWSVGCIF
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| Kinase | ERK-Un.AA | ERK | 93-277 | 36 | 4.4e-39 | 136.16 | In-house | 1-207 (307) | Show / Hide |
Range on Protein: 93-277
Range on HMM: 1-207/307
Sequence Identity: 36% (76 aa)
YLLHEHIGSGSYGDVCRATDCQ-----ASLTVALKRVGDVLCCPLLAKRVLREVCIMRRLS-HRYVITLTDVFISMSMEVSGGIDLYIATEFADGGDMYH
| ... || |.|| || |.| . .|| | . .. |...|| ||| ..| . | .|.| |.... | | . |.|. .|. . |.
YQIIKQIGHGAYGVVCSAIDKEYCFDETGQKVAIKKIENAFDHPIYCKRTLREIKLLRHFKGHENIICLFDIMMPNSPE--QYNDIYCVEELME-TDLHQ
L---REPLTPEHVKFLMWQLLTGMSYIHSCRVWHRDLKSENILLMADMSVKICDFGLSR----SAEE------------VVTPSYRAPEVIMSRGQYSSS
. .|...|....|.|.| |. |||| | ||||| |||. . |||||||.| |..| |.| |||||.. | |...
IINSQQELSDDHCQYFMYQILCGLKYIHSANVIHRDLKPSNILVNSNCDLKICDFGLARCFDASYQENHECNQNFMTEYVATRWYRAPEIMLSWQKYTKA
IDIWSLGCIF
.|||| ||||
MDIWSCGCIF
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| Kinase | ERK-Un.AA | MAPK | 291-367 | 34 | 3.8e-20 | 66.16 | In-house | 244-328 (328) | Show / Hide |
Range on Protein: 291-367 Range on HMM: 244-328/328 Sequence Identity: 34% (29 aa) LDVIFNVIGTPGWSDIESVP-SESWRSYLKHL---PGRVRNLTEQLLGY----VDQEALDLLFRMLAFNPGRRCTAEEALSHIYV . |..|.||| .|. .. ||. |.|.. | | . . |... .. .|.|||..||.|.| .| |.||||.| |. WNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANPQAIDLLEKMLVFDPDKRITVEEALQHPYF |
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| Kinase | ERK-Un.AA | CMGC | 291-367 | 18 | 4.4e-15 | 45.1 | In-house | 363-513 (513) | Show / Hide |
Range on Protein: 291-367
Range on HMM: 363-513/513
Sequence Identity: 18% (28 aa)
LDVIFNVIGTP----------------GWSDIESVP--------------------SESWRSYLKH---LP-GRVRNLTEQLLG----------------
|. ||.|.||| ... .. ||. | |.. .| . ...... .
LFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNW
------------------YVDQEALDLLFRMLAFNPGRRCTAEEALSHIYV
|..|.||| .|| ..| .| |||.||.| |
IYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF
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| Kinase | ERK-Un.AA | p38 | 291-367 | 35 | 1.1e-14 | 46.35 | In-house | 213-289 (289) | Show / Hide |
Range on Protein: 291-367 Range on HMM: 213-289/289 Sequence Identity: 35% (27 aa) LDVIFNVIGTPGWSDIESVPSESWRSYLKHLPGRVRNLTEQLLGYVDQEALDLLFRMLAFNPGRRCTAEEALSHIYV | | .|.||| .. . ||. |.|.. .| . | .... . |.||| .|| | .| |||||..| | LQRIMKVCGTPDEEFWQKIQSEEARNYIQSYPQMPRRDFHHVFMGANPQAIDLLEKMLELDPDKRITAEEAMQHPYF |
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| Kinase | ERK-Un.AA | TyrKc | 93-365 | 20 | 3.7e-13 | -9.97 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 93-365
Range on HMM: 1-280/280
Sequence Identity: 20% (63 aa)
YLLHEHIGSGSYGDVCRATDCQASLTVALKRVGDVLCCPLLAKRVLREVCIMRRL--SHRYVITLTDVFISMS---MEVSGGIDLYIATEFADGGDMYHL
| . .|.| .| |...| ..|| | . . . .|| ||..| .| .. | | .. . |.. |.| .|....|| .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEP---LMIVMEYMPHGDLKDY
R---EP-LTPEHVKFLMWQLLTGMSYIHSCRVWHRDLKSENILLMADMSVKICDFGLSRSAE---------EVVTP----SYR--------APEVIMSRG
.| |.... .|| ||.|.|| .. |||| |.|. .. |||.|||||| . .. .. . . |||.| |
LRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-NYG
QYSSSIDIWSLGCIFW--VSVSSNDITI-----LNLDVIFNVIGTPGWSDIESVP---SESWRSYLKHLPGRVRNLTEQLLGYVDQEALDLLFRMLAFNP
... |.|| | | . .. . ... . . . .. . | .| .. . ...|
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS--------------------F-VCCPDEMYQIMKQCWHEDP
GRRCTAEEALSHI
|.| .| . .
EDRPTFSEIHECF
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| Kinase | ERK-Un.AA | ERK | 291-367 | 36 | 1.1e-12 | 43.68 | In-house | 226-307 (307) | Show / Hide |
Range on Protein: 291-367 Range on HMM: 226-307/307 Sequence Identity: 36% (30 aa) LDVIFNVIGTP-GWSDIESVPSESWRSYLKHLPG--RVRNLTEQLLGY--VDQEALDLLFRMLAFNPGRRCTAEEALSHIYV .. ||..|||| . |.. .|| . |.| || | | . . .|.||| .||.|.| | |.||.|.| | INRIFQIIGTPHSEEDLQYICSENAWKYIKNLPNPVRPPKPWENIFPNANCNPQAIDLLEKMLVFDPDKRITVEECLEHPYF |
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| Kinase | ERK-Un.AA | Pkinase_Tyr | 93-242 | 28 | 4.4e-12 | 41.55 | Pfam | 1-159 (270) | Show / Hide |
Range on Protein: 93-242 Range on HMM: 1-159/270 Sequence Identity: 28% (47 aa) YLLHEHIGSGSYGDVCRATDC----QASLTVALKRVGDVLCCPLLA---KRVLREVCIMRRL-SHRYVITLTDVFISMSMEVSGGID--LYIATEFADGG . . .|.|..|.|...| . ..|| | . . . . . .||. ||. | .| .. | | . . | .|| .|.. .| ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE--GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCT------DQGEPNQIYIVMEYMPHG DMY-HLREP------LTPEHVKFLMWQLLTGMSYIHSCRVWHRDLKSENILLMADMSVKICDFGLSR |.. .||.. ||... || ||.| .| . |||| |.|. .. ||||||||.| DLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLAR |
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| Kinase | ERK-Un.AA | MAPK-Unclassified | 247-277 | 58 | 8e-12 | 38.52 | In-house | 409-439 (575) | Show / Hide |
Range on Protein: 247-277 Range on HMM: 409-439/575 Sequence Identity: 58% (18 aa) VVTPSYRAPEVIMSRGQYSSSIDIWSLGCIF ||| ||||| ..| . |. .||||.|||| VVTRWYRAPEIMLSMHEYDTQVDIWSIGCIF |
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| Kinase | ERK-Un.AA | CDK | 291-367 | 26 | 1.6e-11 | 32.97 | In-house | 234-284 (284) | Show / Hide |
Range on Protein: 291-367 Range on HMM: 234-284/284 Sequence Identity: 26% (21 aa) LDVIFNVIGTPG---WSDIESVPSESWRSYLKHLPGRVRNLTEQLLGYVDQEALDLLFRMLAFNPGRRCTAEEALSHIYV |. ||...||| | .... | ||| .||...| .|..||.||.| | LFKIFRICGTPTEDNWPGVTKLPDY-----------------------------DLLNKMLCYDPKKRISAEQALQHPYF |
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| Kinase | ERK-Un.AA | CAMK | 335-367 | 39 | 2e-09 | 25.79 | In-house | 393-425 (425) | Show / Hide |
Range on Protein: 335-367 Range on HMM: 393-425/425 Sequence Identity: 39% (13 aa) YVDQEALDLLFRMLAFNPGRRCTAEEALSHIYV .|.||. ||. .|| .| .| |.|..|.| . FVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM |
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| Kinase | ERK-Un.AA | MAPK-Unclassified | 291-367 | 26 | 2.2e-09 | 29.57 | In-house | 489-575 (575) | Show / Hide |
Range on Protein: 291-367 Range on HMM: 489-575/575 Sequence Identity: 26% (23 aa) LDVIFNVIGTPGWSDIESVPSESWRSYLKHLPGRVRNLTEQLLGYVDQ----------EALDLLFRMLAFNPGRRCTAEEALSHIYV . .|| . |.| |. . . | | |.. . . .| . |..|.. ||.||| .| ||..||.| |. IKMIFDYLGMPPEEDCNFITCDSARKYIQSFKCKTPVHFTDLMFCKAPGDDQIVRGNCECIDFVQKMLQFNPWKRITADQALEHPYF |
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| Kinase | ERK-Un.AA | CDK | 93-124 | 40 | 7e-06 | 14.59 | In-house | 1-37 (284) | Show / Hide |
Range on Protein: 93-124 Range on HMM: 1-37/284 Sequence Identity: 40% (15 aa) YLLHEHIGSGSYGDVCRATDCQAS-----LTVALKRV | | || |.|| | .| | | ||||.. YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKI |
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