Gene GSK_a-2 (S.moellendorffii)

GSK_a-2

Species: S.moellendorffii
Alias: GSK_a-2
External Links:
Annotation:

Classification

Group: CMGC
Family: GSK

Sequence

Name Sequence Type Origin Length Description Download
GSK_a-2.AA Protein None 423 None Fasta, JSON
GSK_a-2.NA RNA None 1272 None Fasta, JSON
GSK_a-2.kin_dom Protein Kinase Domain None 285 None Fasta, JSON

Protein domain

Protein domains of GSK_a-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase GSK_a-2.AA GSK 87-371 55 1.4e-206 637.78 In-house 1-328 (328) Show / Hide 
Range on Protein: 87-371
Range on HMM: 1-328/328
Sequence Identity: 55% (182 aa)

YVAERVVGTGSFGIVFQAKCL----ETGET----VAIKKVLQDKRYK-NRELQIMRLL---DHPNIVALKHCFFST-TDKDE--LYLN-LVLEYVPETVY
|   .|.|.|||| |.||.      ||.|.    ||||||.|||||| |||||||. |   |||||| ||  | .  ..|||  .|.| ||.||.|.|.|
YEEMKVIGHGSFGVVYQAYMNSPSNETKEIWLGPVAIKKVWQDKRYKCNRELQIMKMLGKLDHPNIVRLKYFFYMHYEKKDENHVYCNCLVMEYMPQTLY

RIAKHHNRMNQRMPLLYVKLYTYQICRSLAYIHGGIGVCHRDIKPQNLLVNPHTHQLKLCDFGSAKVLVK--GEPNISYICSRYYRAPELIFGATEYTTA
....|... .|.||....|||.||..|.|||.| ..|.|||||||||.||.| |..||.||||||| |..  .||||||||||||||||||||.|.||..
QVIRHYVKNKQQMPIIHIKLYMYQMFRGLAYLH-SHGICHRDIKPQNILVDPDTGVLKICDFGSAKQLEPNKNEPNISYICSRYYRAPELIFGCTNYTCQ

IDIWSMGCVLAELLLGQPLFPGESGVDQLVEIIKVLGTPTREEIKCMNPNYTEFKFP-----QIKAHPWHK-------------------VFHK-RMPPE
||.||.|||.||.|.|||||||.|.|||||||||.|||||.|.|. |||.|.|||||     |||.||| |                   .|.. . ...
IDVWSCGCVMAEMLKGQPLFPGDSSVDQLVEIIKMLGTPTKEQIQSMNPSYPEFKFPYWSFQQIKPHPWQKNDTKYEYQTYYHKKYRTVYMFKWCHTDMQ

-AVDLVSRLLQYSPNLRCSSLEALAHPFF
 ..||.|..|.| |. |.| |||.|||||
DWIDLISKCLVYDPKKRLSPLEACAHPFF
Kinase GSK_a-2.AA CMGC 87-371 22 5.4e-126 416.34 In-house 1-513 (513) Show / Hide 
Range on Protein: 87-371
Range on HMM: 1-513/513
Sequence Identity: 22% (116 aa)

YVAERVVGTGSFGIVFQAKC--------------LETGETVAIKKVLQDKRYKN----------------RELQIMRLL-----------------DHPN
|   ...| |..|.|.....               ||.| |||||. ... |..                ||..|.. |                 .|.|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IVALKHCFFSTTDKDEL------------YLNLVLEYVPETVYRIAKHHN------------------------RMNQRMPLLYVKLYTYQICRSLA--Y
|| |. .| .  .. ..            .|.|| ||.. . |.. |...                        .. . ... ... |.|||.|.|.  |
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKY

IHGGIG-VCHRDIKPQNLLVNPHT-------------------HQLKLCDFGSAKVLVKG----------------------EPNISYICSRYYRAPELI
.|   | ..|||.||.|.|.|. .                    .||.||||.|. . .                       .|. .|...|.|||||..
CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEIL

FGA---------TEYTTAIDIWSMGCVLAELLLG--------QPLFPGESG-----------VDQLVEIIKVLGTPT---------------REEIKCMN
.|.         ..|||.||.|| ||..||...|        .|||||.|.           .||| .|.|||||||                ||.  |.
LGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMI

PNYTEFK---------------------------FPQIKAHPWHKVFHK----------------------------------RMPPEAVDLVSRLLQYS
.... .|                           ||... .||...| .                                  ...|.|.||....||| 
KLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYD

PNLRCSSLEALAHPFF
|. | .  .||.||.|
PDKRITAEQALQHPYF
Kinase GSK_a-2.AA Pkinase 87-371 30 4e-97 333.76 Pfam 1-293 (293) Show / Hide 
Range on Protein: 87-371
Range on HMM: 1-293/293
Sequence Identity: 30% (95 aa)

YVAERVVGTGSFGIVFQAKCLETGETVAIKKVLQDKRYKNR--------ELQIMRLLDHPNIVALKHCFFSTTDKDELYLNLVLEYVPETVYRIAKHH--
|. .|..| |||| |....   ||..||.|..  ... ..         |.|||. |.||||| |...| .   ||..|  .|.||.. ..|  .  .  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED---KDHIY--MVMEYCEGGLY-VMDLFDY

--NRMNQRM--PLLYVKLYTYQICRSLAYIHGGIGVCHRDIKPQNLLVNPHTHQL----KLCDFGSAKV--LVKGEPNISYICSRYYRAPELIFGATEYT
   ... ..  .   .| | |||.| |.|.|   |..|||.||.|.|.. .. ..    |.||||.||.  . ... . .. ....|.|||.| |...|.
ISTWRHGCFYFSEWECKFYMYQILRGLEYCHS-MGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYG

TAIDIWSMGCVLAELLLGQPLFPGE----SGVDQLVEIIKVLGTPTREEIKCMNPNYTEFKFPQIKAHPWHKVFHKRMPPEAVDLVSRLLQYSPNLRCSS
...|.||.||.|.|.|.|.|.|||.    . .||.. | ...|.|.....   ......| |.. . |. |..| .....|. |.....|.. |. |.. 
PKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-HF-HWTF-HNWSEECKDFIKWCLCKDPKKRPTA

LEALAHPFF
 ..| ||.|
EQILQHPWF
Kinase GSK_a-2.AA S_TKc 87-371 29 1.2e-91 311.72 SMART 1-231 (231) Show / Hide 
Range on Protein: 87-371
Range on HMM: 1-231/231
Sequence Identity: 29% (88 aa)

YVAERVVGTGSFGIVFQAKCLETGETVAIKKVLQDKRYKNRELQIMRLLDHPNIVALKHCFFSTTDKDELYLNLVLEYVPE---TVYRIAKHHNR--MNQ
|   |..| |.|| |....  .||. ||||..    .   ||.||..  .||||| |. .| .       .| .|.||..    ..... |...|   ..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---EHIRREIQILKK-HHPNIVKLYDVFQD------DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

RMPLLYVKLYTYQICRSLAYIHGGIGVCHRDIKPQNLLVNPHTHQLKLCDFGSAKVLVKGEPNISYICSRYYRAPELIFGATEYTT-AIDIWSMGCVLAE
..|   .. |.||||. |.|.|   |..|||.||.|.|..    ..|.||||.|..|       ... ...|.|||..     |.. ..|.|| ||.|.|
PFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE---HIKICDFGLARQL------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYE

LLLGQPLFPGESGVDQLVEIIKVLGTPTREEIKCMNPNYTEFKFPQIKAHPWHKVFHKRMPPEAVDLVSRLLQYSPNLRCSSLEALA-------HPFF
.| |.|.||      |. ...|..|                                   .||| |.....||. |. | .  |||.       ||.|
MLCGYPPFP------QMQMMFKKIG-----------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase GSK_a-2.AA CDK 87-371 28 6.2e-79 252.15 In-house 1-284 (284) Show / Hide 
Range on Protein: 87-371
Range on HMM: 1-284/284
Sequence Identity: 28% (94 aa)

YVAERVVGTGSFGIVFQAKCLETG-----ETVAIKKVL--------QDKRYKN---RELQIMRLLDHPNIVALKHCFFST-TDKD-----ELYLNLVLEY
|     .| |..|.|. |....||     . ||.||.          .        ||  ... | ||||| |. .. .  .|..     |  | .| ||
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

VPETVYRIAKHHNRMNQRMPLLYVKLYTYQICRSLAYIHGGIGVCHRDIKPQNLLVNPHTH----QLKLCDFGSAKVLVK------GEPNIS-YICSRYY
..   . . .             .| |..|. | |.|.|   .. |||.||||.|.|   .    .||. ||| |.               .  .  . |
MDHDLKKYMD-------------IKCYMWQLLRGLHYCHS-NWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWY

RAPELIFGATEYT--TAIDIWSMGCVLAELLL---GQPLFPGESGVDQLVEIIKVLGTPTRE---EIKCMNPNYTEFKFPQIKAHPWHKVFHKRMPPEAV
||||| .|...|.  |.||.|| ||..||...   ..|||||.|  |||  |....|||| .   ... . |.|                          
RAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKL-PDY--------------------------

DLVSRLLQYSPNLRCSSLEALAHPFF
|| ...|.| |. |.|. .|| ||.|
DLLNKMLCYDPKKRISAEQALQHPYF
Kinase GSK_a-2.AA RCK 87-371 32 1.3e-77 245.72 In-house 1-298 (298) Show / Hide 
Range on Protein: 87-371
Range on HMM: 1-298/298
Sequence Identity: 32% (100 aa)

YVAERVVGTGSFGIVFQAKCLETGETVAIKKVLQDKRYKN-------RELQIMRLLD-HPNIVALKHCFFSTTDKD--ELYLNLVLEYVPETVYRIAKHH
| . . .| |..| |. |. .|||| |||||    .....       ||.. .| |  ||||. ||  ..   |.|  .||  .|.||. . .|   |. 
YQIIKQLGDGTYGCVMKAQNKETGEIVAIKKMK--QKFYSWEECMNLREIKSLRKLNPHPNIIKLKEVIR---DNDTYQLY--FVFEYMDMNLYQMMKDF

NRMNQRMPLLY--VKLYTYQICRSLAYIHGGIGVCHRDIKPQNLLVNPH--------THQLKLCDFGSAKVLVKGEPNISYICSRYYRAPELIFGATEYT
   ....|     .| . |||. .||..|   |  |||.|| |.....         .  .|..|||...      |.  |. .|.|||||..  .| |.
KERRKYLPENQRSIKNIMYQILQGLAHMH-KHGFFHRDLKPENIMCTGSQQYFEDQDQDHIKIADFGLCREIRSKPPYTDYVSTRWYRAPECLLRCTYYN

TAIDIWSMGCVLAELLLGQPLFPGESGVDQLVEIIKVLGTPTREE-IKCM-NPNYTEFKFPQIKAHPWHKVFHKRMPPEAVDLVSRLLQYSPNLRCSSLE
. .|||..||. .||   .||||| | .||. .|.||.|||. ..  .     . ..|.||| |. |  ...   .......|.  .||. |. | .  .
SPMDIWAVGCIMYELYMLRPLFPGSSEIDQIFKICKVMGTPNKKDWPDGYKLASQMNFNFPQCKGMPLKQLIPN-CSQDCIELMEKMLQWDPQKRITAQQ

ALAHPFF
|| ||.|
ALQHPYF
Kinase GSK_a-2.AA CDC2 87-371 32 8.9e-74 225.98 In-house 1-301 (301) Show / Hide 
Range on Protein: 87-371
Range on HMM: 1-301/301
Sequence Identity: 32% (101 aa)

YVAERVVGTGSFGIVFQAKCLETGETVAIKKVLQDKRYKN--------RELQIMRLLD-HPNIVALKHCFFSTTDKDELYLNLVLEYVPETVYRIAKHHN
|   . .| |..|.|...| ..|.. ||.||.  .             ||. ..  |. ||||| |.  ...      ||  .| ||.     .  .  .
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ----NKLY--MVFEYLDMDLKKYMDMSI

RMNQRMPLLYVKLYTYQICRSLAYIHGGIGVCHRDIKPQNLLVNPHTHQLKLCDFGSAKVLVKGEPNISYICS-----RYYRAPELIFGATEYTTAIDIW
  |. ||. .|| |.|||.. ... |   .. |||.||||.|..     .|. ||| |.    | |   |        . |||||. .|.  |.|..|.|
PKNKHMPPQLVKSYMYQILQGVHFCH-QRRIMHRDLKPQNILIDKKGN-IKIADFGLARAF--GIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMW

SMGCVLAEL---LLGQPLFPGESGVDQLVEIIKVLGTPTREEIK--CMNPNYTEFKFPQIKAHPWHKVFHK--------RMPPEAVDLVSRLLQYSPNLR
| ||..||.       |||.|.|  |||  | ..||||. ..    . .| | . .||. |.    |.. .         ..||..|| ...||| |. |
SIGCIFAEMFMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPDYKN-TFPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKR

CSSLEALAHPFF
 |. |||.||.|
ISAKEALQHPYF
Kinase GSK_a-2.AA CDKL 87-371 37 3.5e-64 218.31 In-house 1-286 (286) Show / Hide 
Range on Protein: 87-371
Range on HMM: 1-286/286
Sequence Identity: 37% (111 aa)

YVAERVVGTGSFGIVFQAKCLETGETVAIKKVLQ---DKRYK---NRELQIMRLLDHPNIVALKHCFFSTTDKDELYLNLVLEYVPETVYRIAKHHNRMN
|    .|| || | |.  .  |||. ||||| .    |.  |    ||. . . | |.||| |.  |     | .|.  || ||.  ||  . ..   . 
YEKLGKVGEGSYGVVMKCRNKETGQIVAIKKFKESEDDPMVKKIAMREIKMLKQLKHENIVNLIEVF---RRKRKLH--LVFEYCDHTVLHELEE---YP

QRMPLLYVKLYTYQICRSLAYIHGGIGVCHRDIKPQNLLVNPHTHQLKLCDFGSAKVLV-KGEPNISYICSRYYRAPELIFGATEYTTAIDIWSMGCVLA
.  .   |. |..||...... |    . |||||| |.|..|.  |.|||||| |. |  .||    |   | ||||||  | |.| ...|||. |||.|
NGVDEHVVRKYMWQILKAINFCH-KHNCIHRDIKPENILITPKNGQVKLCDFGFARMLAKPGEIYTDYVATRWYRAPELLVGDTQYGKPVDIWAIGCVMA

ELLLGQPLFPGESGVDQLVEIIKVLG--TPTREEIKCMNPNYTEFKFPQIK-AHPWHKVFHKRMPPEAVDLVSRLLQYSPNLRCSSLEALAHPFF
|.. ||||.||.| .|||  |.|.||  .|  .||  .|| .   |||.|.   |  | . .   ..| |..  .|. .|  | .. ... ||.|
EMIDGQPLWPGQSDIDQLYHIQKCLGPLIPRHQEIFSKNPFFHGMKFPEIEHMEPLEKRYPNKSNKKALDFMKKCLHMDPDERMTCEQLMHHPYF
Kinase GSK_a-2.AA CDK5 87-371 35 3.3e-61 191.93 In-house 1-287 (287) Show / Hide 
Range on Protein: 87-371
Range on HMM: 1-287/287
Sequence Identity: 35% (106 aa)

YVAERVVGTGSFGIVFQAKCLETGETVAIKKVLQDKR------YKNRELQIMRLLDHPNIVALKHCFFSTTDKDELYLNLVLEYVPETVYRIAKHHNRMN
|     .| | .|.|. |.  ||.| ||.|.|  |           ||  ... | |.||| |     |     |  | || |.. .    . |. . .|
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLDSEDEGVPSTAIREICLLKELKHKNIVRLHDVIHS-----EKKLTLVFEFCDQD---LKKYMDSCN

QRMPLLYVKLYTYQICRSLAYIHGGIGVCHRDIKPQNLLVNPHTHQLKLCDFGSAKVLVKGEPNISY---ICSRYYRAPELIFGATEYTTAIDIWSMGCV
  | .  .| . ||  . ||. |    | ||| ||||||.|    .||| ||| |     | |   |   .    ||.|   .|.  |.| ||.||.||.
GEMDMHIIKSFMYQLLKGLAFCH-EHHVLHRDLKPQNLLIN-KNGELKLADFGLARAF--GIPVRCYSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCI

LAELL-LGQPLFPGESGVDQLVEIIKVLGTPTREEIKCMN--PNYT--EFKFPQIKAHP-WHKVFHKRMPPEAVDLVSRLLQYSPNLRCSSLEALAHPFF
.||.   |.||||| .  |||  | |..|||. ..   .   |.|     ..|   ||. | .. .| .  .  || ...||. || | |  .|| ||.|
FAEMANAGRPLFPGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPK-LDEKGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase GSK_a-2.AA MAPK 192-371 37 1.4e-60 207.6 In-house 121-328 (328) Show / Hide 
Range on Protein: 192-371
Range on HMM: 121-328/328
Sequence Identity: 37% (79 aa)

TYQICRS--LAYIHGGIGVCHRDIKPQNLLVNPHTHQLKLCDFGSAKVLVKGEPNI---------------SYICSRYYRAPELIFG--ATEYTTAIDIW
.|||.|   | ||| . .| |||.|| |.|||    .||.|||| | ..   .  .                |.  |.|||||....  ...||.|.|.|
MYQILRGLKLKYIHSA-NVIHRDLKPSNILVN-ENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAPEIMLNWIWMHYTKAVDMW

SMGCVLAELLL-GQPLFPGESGVDQLVEIIKVLGTPTREEIKCMN-P----NYTE-FK-FPQIKAHPWHKVFHK---RMPPEAVDLVSRLLQYSPNLRCS
| || .||.|  ..|||||.. .||.  |..|||||..| |.|.  .    || . .. .|. ...||.|.| .   .  |.|.||....|. .|. | .
SVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANPQAIDLLEKMLVFDPDKRIT

SLEALAHPFF
  |||.||.|
VEEALQHPYF
Kinase GSK_a-2.AA ERK7 87-371 31 4e-59 200.75 In-house 1-292 (292) Show / Hide 
Range on Protein: 87-371
Range on HMM: 1-292/292
Sequence Identity: 31% (94 aa)

YVAERVVGTGSFGIVFQAKCLETGETVAIKKVLQ------DKRYKNRELQIMRLLD-HPNIVALKHCFFSTTDKDELYLNLVLEYVPETVYRIAKHHNRM
|  .. .| | .|||  | .  |...||.||.        |     ||  ... .. ||||. |   .    |.| .|  || |.       . .. | .
YEIRKRLGKGAYGIVWKAYDKRTKQVVALKKIFDAFRNQTDAQRTFREIMFLQEFHCHPNIIRLINVIRADNDRD-IY--LVFEFMETDLHAVIRKGNIL

NQRMPLLYVKLYTYQICRSLAYIHGGIGVCHRDIKPQNLLVNPHTHQLKLCDFGSAKVLVKGE------PNIS-YICSRYYRAPELIFGATEYTTAIDIW
        ..   ||. | . |.| |  | |||.|| |.|..   . .|.|||| |  . . |      | .  |.  | |||||   |...|| ..| |
KD----IHKQYIMYQLLRAIKYMHSGN-VIHRDLKPSNILLDSECM-VKVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMW

SMGCVLAELLLGQPLFPGESGVDQLVEIIKVLGTPTREEIKCMNPNYTEF---KFPQIKAHPWHKVFHKRMPPEAVDLVSRLLQYSPNLRCSSLEALAHP
|.||.|.|.| |.|.||| | ..|.  |..... ||.|.|. ....|      . .| | .. ....    ...|.||. |||.. |. | .  .||.||
SIGCILGEMLRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMP-QCCDDAIDLLKRLLVFNPKKRLTAEQALQHP

FF
. 
YV
Kinase GSK_a-2.AA ERK 192-371 36 3e-55 189.89 In-house 114-307 (307) Show / Hide 
Range on Protein: 192-371
Range on HMM: 114-307/307
Sequence Identity: 36% (72 aa)

TYQICRSLAYIHGGIGVCHRDIKPQNLLVNPHTHQLKLCDFGSAKVLVKGEPNI---------SYICSRYYRAPELIFGATEYTTAIDIWSMGCVLAELL
.||| . | |||   .| |||.|| |.|||    .|| |||| | ..  .  ..          |. .|.|||||..  ...||.|.|||| || .||.|
MYQILCGLKYIHSA-NVIHRDLKPSNILVNSNC-DLKICDFGLARCFDASYQENHECNQNFMTEYVATRWYRAPEIMLSWQKYTKAMDIWSCGCIFAEML

LGQPLFPGESGVDQLVEIIKVLGTP-TREEIKCM-NPNYTEF--KFPQ--IKAHPWHKVFHKRMP--PEAVDLVSRLLQYSPNLRCSSLEALAHPFF
 ..|||||.. |.|. .|....||| . |....  ..|. ..  ..|   ... || ..| .. .  |.|.|| ...|.  |. | .  |.|.||.|
GRKPLFPGKDYVHQINRIFQIIGTPHSEEDLQYICSENAWKYIKNLPNPVRPPKPWENIF-PNANCNPQAIDLLEKMLVFDPDKRITVEECLEHPYF
Kinase GSK_a-2.AA MAPK 87-158 23 4.3e-15 48.42 In-house 1-93 (328) Show / Hide 
Range on Protein: 87-158
Range on HMM: 1-93/328
Sequence Identity: 23% (22 aa)

YVAERVVGTGSFGIVFQAKCLE------TGETVAIKKV---LQDKRYKN---RELQIMRLL-DHPNIVALKHCFFST-----TDK---DELYL
|.  . .| |..|.|. |.. .      .|..|||||.    |.. .     ||. ..| . .|.||. |...|  .      ..   ...|.
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYI
Kinase GSK_a-2.AA TyrKc 87-371 22 1.4e-14 12.95 SMART 1-280 (280) Show / Hide 
Range on Protein: 87-371
Range on HMM: 1-280/280
Sequence Identity: 22% (70 aa)

YVAERVVGTGSFGIVFQAKCLETGETVAIKKVLQDKRYKN--RELQIMRLL--DHPNIVALKHCFFSTTDK------DELYLNLVLEYVPE--TVYRIAK
 . ... | | ||.|....     ..||.|..  |.  .   ||..||. |  .|||||.|  .   |...      . |.  .|.||.|      .. |
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGV--CTQQGRNFMYIEPLM--IVMEYMPHGDLKDYLRK

HHNRMNQRMPLLYVKLYTYQICRSLAYIHGGIGVCHRDIKPQNLLVNPHTHQLKLCDFGSAKVLVKG----EPNISYI-----CSR-----YYRAPELIF
|...     ..     . .||..  .|.|   .. |||.   | ||.    . | .||| .. .  .    |    |      ...        ||| | 
HRPK----LCMKDLLSFCWQIACGMEYLHSK-NCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-

GATEYTTAIDIWSMGCVLAELL-LGQPLFPGE----SGVDQLVEIIKVLGTPTREEIKCMNPNYTEFKFPQIKAHPWHKVFHKRMPPEAVDLVSRLLQYS
   ..||. |.|| | .. |.. .||.  ||.       ....| .|  . . . .  .  |                  |  ..|.|  .. ..  .. 
NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY--P-MS---------------F-VCCPDEMYQIMKQCWHED

PNLRCSSLEALAHPFF
|. |..  |   | .|
PEDRPTFSEI--HECF
Kinase GSK_a-2.AA Pkinase_Tyr 87-166 27 2.3e-11 39.11 Pfam 1-90 (270) Show / Hide 
Range on Protein: 87-166
Range on HMM: 1-90/270
Sequence Identity: 27% (26 aa)

YVAERVVGTGSFGIVFQAKCL----ETGETVAIKKVLQDKRYKN-------RELQIMRLL-DHPNIVALKHCFFSTTDKDEL-YLNLVLEYVP
 .  .. | |.|| |.....     .|. .||.|.. ..   ..       ||..||. | .||||| |  .     |..|  .. .|.||.|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCT---DQGEPNQIYIVMEYMP
Kinase GSK_a-2.AA ERK 87-145 30 1.8e-09 31.58 In-house 1-71 (307) Show / Hide 
Range on Protein: 87-145
Range on HMM: 1-71/307
Sequence Identity: 30% (22 aa)

YVAERVVGTGSFGIVFQAKCLE-----TGETVAIKKV---LQDKRYKN---RELQIMRLLD-HPNIVALKH
|     .| |..|.|. |.  |     ||..|||||.     ...| .   ||. ..|... |.||. |..
YQIIKQIGHGAYGVVCSAIDKEYCFDETGQKVAIKKIENAFDHPIYCKRTLREIKLLRHFKGHENIICLFD