Gene GSK_b (S.moellendorffii)

GSK_b

Species: S.moellendorffii
Alias: GSK_b
External Links:
Annotation:

Classification

Group: CMGC
Family: GSK

Sequence

Name Sequence Type Origin Length Description Download
GSK_b.AA Protein None 380 None Fasta, JSON
GSK_b.NA RNA None 1143 None Fasta, JSON
GSK_b.kin_dom Protein Kinase Domain None 285 None Fasta, JSON

Protein domain

Protein domains of GSK_b.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase GSK_b.AA GSK 44-328 54 1.9e-203 627.98 In-house 1-328 (328) Show / Hide 
Range on Protein: 44-328
Range on HMM: 1-328/328
Sequence Identity: 54% (178 aa)

YVAERVVGTGSFGIVFQAKCL----ETGET----VAIKKVLQDKRYK-NRELQIMRLL---DHPSIVSLKHCFFST-TDKDE--LYLN-LVLEYVPETVY
|   .|.|.|||| |.||.      ||.|.    ||||||.|||||| |||||||. |   ||| ||.||  | .  ..|||  .|.| ||.||.|.|.|
YEEMKVIGHGSFGVVYQAYMNSPSNETKEIWLGPVAIKKVWQDKRYKCNRELQIMKMLGKLDHPNIVRLKYFFYMHYEKKDENHVYCNCLVMEYMPQTLY

RIAKHYNRMNQRMPLLYVKLYTYQICRALTYIHGGMGVCHRDIKPQNLLVNPHTHQLKLCDFGSAKVLVK--GEPNISYICSRYYRAPELIFGATDYTTA
....||.. .|.||....|||.||..|.| |.|. . .|||||||||.||.| |..||.||||||| |..  .||||||||||||||||||||.|.||..
QVIRHYVKNKQQMPIIHIKLYMYQMFRGLAYLHSHG-ICHRDIKPQNILVDPDTGVLKICDFGSAKQLEPNKNEPNISYICSRYYRAPELIFGCTNYTCQ

IDIWSTGCVLAELLLGQPLFPGESGVDQLVEIIKVLGTPTREEIKCMNPNYTEFKFP-----QIKAHPWHK-------------------VFHK-RMPPE
||.|| |||.||.|.|||||||.|.|||||||||.|||||.|.|. |||.|.|||||     |||.||| |                   .|.. . ...
IDVWSCGCVMAEMLKGQPLFPGDSSVDQLVEIIKMLGTPTKEQIQSMNPSYPEFKFPYWSFQQIKPHPWQKNDTKYEYQTYYHKKYRTVYMFKWCHTDMQ

-AVDLVSRLLQYSPSLRCNALEALVHPFF
 ..||.|..|.| |. |...|||. ||||
DWIDLISKCLVYDPKKRLSPLEACAHPFF
Kinase GSK_b.AA CMGC 44-328 22 1.8e-125 414.58 In-house 1-513 (513) Show / Hide 
Range on Protein: 44-328
Range on HMM: 1-513/513
Sequence Identity: 22% (116 aa)

YVAERVVGTGSFGIVFQAKC--------------LETGETVAIKKVLQDKRYKN----------------RELQIMRLL-----------------DHPS
|   ...| |..|.|.....               ||.| |||||. ... |..                ||..|.. |                 .|. 
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IVSLKHCFFSTTDKDEL------------YLNLVLEYVPETVYRIAKHYN------------------------RMNQRMPLLYVKLYTYQICRALT--Y
||.|. .| .  .. ..            .|.|| ||.. . |.. |...                        .. . ... ... |.|||.|.|   |
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKY

IHGGMG-VCHRDIKPQNLLVNPHT-------------------HQLKLCDFGSAKVLVKG----------------------EPNISYICSRYYRAPELI
.|   | ..|||.||.|.|.|. .                    .||.||||.|. . .                       .|. .|...|.|||||..
CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEIL

FGA---------TDYTTAIDIWSTGCVLAELLLG--------QPLFPGESG-----------VDQLVEIIKVLGTPT---------------REEIKCMN
.|.         ..|||.||.|| ||..||...|        .|||||.|.           .||| .|.|||||||                ||.  |.
LGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMI

PNYTEFK---------------------------FPQIKAHPWHKVFHK----------------------------------RMPPEAVDLVSRLLQYS
.... .|                           ||... .||...| .                                  ...|.|.||....||| 
KLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYD

PSLRCNALEALVHPFF
|. |  | .|| ||.|
PDKRITAEQALQHPYF
Kinase GSK_b.AA Pkinase 44-328 31 5.8e-95 326.59 Pfam 1-293 (293) Show / Hide 
Range on Protein: 44-328
Range on HMM: 1-293/293
Sequence Identity: 31% (96 aa)

YVAERVVGTGSFGIVFQAKCLETGETVAIKKVLQDKRYKNR--------ELQIMRLLDHPSIVSLKHCFFSTTDKDELYLNLVLEYVPETVYRIAKHY--
|. .|..| |||| |....   ||..||.|..  ... ..         |.|||. |.|| || |...| .   ||..|  .|.||.. ..|  .  .  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED---KDHIY--MVMEYCEGGLY-VMDLFDY

--NRMNQRM--PLLYVKLYTYQICRALTYIHGGMGVCHRDIKPQNLLVNPHTHQL----KLCDFGSAKV--LVKGEPNISYICSRYYRAPELIFGATDYT
   ... ..  .   .| | |||.|.| |.|  ||..|||.||.|.|.. .. ..    |.||||.||.  . ... . .. ....|.|||.| |...|.
ISTWRHGCFYFSEWECKFYMYQILRGLEYCHS-MGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYG

TAIDIWSTGCVLAELLLGQPLFPGE----SGVDQLVEIIKVLGTPTREEIKCMNPNYTEFKFPQIKAHPWHKVFHKRMPPEAVDLVSRLLQYSPSLRCNA
...|.|| ||.|.|.|.|.|.|||.    . .||.. | ...|.|.....   ......| |.. . |. |..| .....|. |.....|.. |. |..|
PKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-HF-HWTF-HNWSEECKDFIKWCLCKDPKKRPTA

LEALVHPFF
 ..| ||.|
EQILQHPWF
Kinase GSK_b.AA S_TKc 44-328 29 6.5e-89 302.61 SMART 1-231 (231) Show / Hide 
Range on Protein: 44-328
Range on HMM: 1-231/231
Sequence Identity: 29% (89 aa)

YVAERVVGTGSFGIVFQAKCLETGETVAIKKVLQDKRYKNRELQIMRLLDHPSIVSLKHCFFSTTDKDELYLNLVLEYVPE---TVYRIAKHYNR--MNQ
|   |..| |.|| |....  .||. ||||..    .   ||.||..  .|| || |. .| .       .| .|.||..    ..... |...|   ..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---EHIRREIQILKK-HHPNIVKLYDVFQD------DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

RMPLLYVKLYTYQICRALTYIHGGMGVCHRDIKPQNLLVNPHTHQLKLCDFGSAKVLVKGEPNISYICSRYYRAPELIFGATDYTT-AIDIWSTGCVLAE
..|   .. |.||||.|| |.|   |..|||.||.|.|..    ..|.||||.|..|       ... ...|.|||..     |.. ..|.|| ||.|.|
PFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE---HIKICDFGLARQL------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYE

LLLGQPLFPGESGVDQLVEIIKVLGTPTREEIKCMNPNYTEFKFPQIKAHPWHKVFHKRMPPEAVDLVSRLLQYSPSLRCNALEALV-------HPFF
.| |.|.||      |. ...|..|                                   .||| |.....||. |. |  | |||        ||.|
MLCGYPPFP------QMQMMFKKIG-----------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase GSK_b.AA CDK 44-328 28 9e-78 248.37 In-house 1-284 (284) Show / Hide 
Range on Protein: 44-328
Range on HMM: 1-284/284
Sequence Identity: 28% (93 aa)

YVAERVVGTGSFGIVFQAKCLETG-----ETVAIKKVL--------QDKRYKN---RELQIMRLLDHPSIVSLKHCFFST-TDKD-----ELYLNLVLEY
|     .| |..|.|. |....||     . ||.||.          .        ||  ... | || ||.|. .. .  .|..     |  | .| ||
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

VPETVYRIAKHYNRMNQRMPLLYVKLYTYQICRALTYIHGGMGVCHRDIKPQNLLVNPHTH----QLKLCDFGSAKVLVK------GEPNIS-YICSRYY
..   . . .             .| |..|. |.| |.|   .. |||.||||.|.|   .    .||. ||| |.               .  .  . |
MDHDLKKYMD-------------IKCYMWQLLRGLHYCHS-NWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWY

RAPELIFGATDYT--TAIDIWSTGCVLAELLL---GQPLFPGESGVDQLVEIIKVLGTPTRE---EIKCMNPNYTEFKFPQIKAHPWHKVFHKRMPPEAV
||||| .|...|.  |.||.|| ||..||...   ..|||||.|  |||  |....|||| .   ... . |.|                          
RAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKL-PDY--------------------------

DLVSRLLQYSPSLRCNALEALVHPFF
|| ...|.| |. |..| .|| ||.|
DLLNKMLCYDPKKRISAEQALQHPYF
Kinase GSK_b.AA MAPK 44-328 30 2.8e-77 263.03 In-house 1-328 (328) Show / Hide 
Range on Protein: 44-328
Range on HMM: 1-328/328
Sequence Identity: 30% (104 aa)

YVAERVVGTGSFGIVFQAKCLE------TGETVAIKKV---LQDKRYKN---RELQIMRLL-DHPSIVSLKHCFFST-----TDK---DELYLNLVLEYV
|.  . .| |..|.|. |.. .      .|..|||||.    |.. .     ||. ..| . .|. |..|...|  .      ..   ...|  .| |. 
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIY--IVMELM

PETVYRIAKHYNRMNQRMPLLYVKLYTYQICRA--LTYIHGGMGVCHRDIKPQNLLVNPHTHQLKLCDFGSAKVLVKGEPNI---------------SYI
    ..| |  .     .    ..  .|||.|.  | |||  ..| |||.|| |.|||    .||.|||| | ..   .  .                |.
ETDLHQIIKSQQ----PLSDDHIQYFMYQILRGLKLKYIH-SANVIHRDLKPSNILVN-ENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYV

CSRYYRAPELIFG--ATDYTTAIDIWSTGCVLAELLL-GQPLFPGESGVDQLVEIIKVLGTPTREEIKCMN-P----NYTE-FK-FPQIKAHPWHKVFHK
  |.|||||....  ...||.|.|.|| || .||.|  ..|||||.. .||.  |..|||||..| |.|.  .    || . .. .|. ...||.|.| .
ATRWYRAPEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPN

---RMPPEAVDLVSRLLQYSPSLRCNALEALVHPFF
   .  |.|.||....|. .|. | .. ||| ||.|
ANFNANPQAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase GSK_b.AA RCK 44-328 32 8.5e-76 239.92 In-house 1-298 (298) Show / Hide 
Range on Protein: 44-328
Range on HMM: 1-298/298
Sequence Identity: 32% (99 aa)

YVAERVVGTGSFGIVFQAKCLETGETVAIKKVLQDKRYKN-------RELQIMRLLD-HPSIVSLKHCFFSTTDKD--ELYLNLVLEYVPETVYRIAKHY
| . . .| |..| |. |. .|||| |||||    .....       ||.. .| |  || |. ||  ..   |.|  .||  .|.||. . .|   |..
YQIIKQLGDGTYGCVMKAQNKETGEIVAIKKMK--QKFYSWEECMNLREIKSLRKLNPHPNIIKLKEVIR---DNDTYQLY--FVFEYMDMNLYQMMKDF

NRMNQRMPLLY--VKLYTYQICRALTYIHGGMGVCHRDIKPQNLLVNPH--------THQLKLCDFGSAKVLVKGEPNISYICSRYYRAPELIFGATDYT
   ....|     .| . |||. .| ..|   |  |||.|| |.....         .  .|..|||...      |.  |. .|.|||||..  .| |.
KERRKYLPENQRSIKNIMYQILQGLAHMH-KHGFFHRDLKPENIMCTGSQQYFEDQDQDHIKIADFGLCREIRSKPPYTDYVSTRWYRAPECLLRCTYYN

TAIDIWSTGCVLAELLLGQPLFPGESGVDQLVEIIKVLGTPTREE-IKCM-NPNYTEFKFPQIKAHPWHKVFHKRMPPEAVDLVSRLLQYSPSLRCNALE
. .|||. ||. .||   .||||| | .||. .|.||.|||. ..  .     . ..|.||| |. |  ...   .......|.  .||. |. | .| .
SPMDIWAVGCIMYELYMLRPLFPGSSEIDQIFKICKVMGTPNKKDWPDGYKLASQMNFNFPQCKGMPLKQLIPN-CSQDCIELMEKMLQWDPQKRITAQQ

ALVHPFF
|| ||.|
ALQHPYF
Kinase GSK_b.AA CDC2 44-328 32 8.8e-73 222.87 In-house 1-301 (301) Show / Hide 
Range on Protein: 44-328
Range on HMM: 1-301/301
Sequence Identity: 32% (100 aa)

YVAERVVGTGSFGIVFQAKCLETGETVAIKKVLQDKRYKN--------RELQIMRLLD-HPSIVSLKHCFFSTTDKDELYLNLVLEYVPETVYRIAKHYN
|   . .| |..|.|...| ..|.. ||.||.  .             ||. ..  |. || ||.|.  ...      ||  .| ||.     .  . ..
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ----NKLY--MVFEYLDMDLKKYMDMSI

RMNQRMPLLYVKLYTYQICRALTYIHGGMGVCHRDIKPQNLLVNPHTHQLKLCDFGSAKVLVKGEPNISYICS-----RYYRAPELIFGATDYTTAIDIW
  |. ||. .|| |.|||.... . |  ... |||.||||.|..     .|. ||| |.    | |   |        . |||||. .|. .|.|..|.|
PKNKHMPPQLVKSYMYQILQGVHFCH-QRRIMHRDLKPQNILIDKKGN-IKIADFGLARAF--GIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMW

STGCVLAEL---LLGQPLFPGESGVDQLVEIIKVLGTPTREEIK--CMNPNYTEFKFPQIKAHPWHKVFHK--------RMPPEAVDLVSRLLQYSPSLR
| ||..||.       |||.|.|  |||  | ..||||. ..    . .| | . .||. |.    |.. .         ..||..|| ...||| |. |
SIGCIFAEMFMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPDYKN-TFPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKR

CNALEALVHPFF
 .| ||| ||.|
ISAKEALQHPYF
Kinase GSK_b.AA CDKL 44-328 37 1.1e-62 213.12 In-house 1-286 (286) Show / Hide 
Range on Protein: 44-328
Range on HMM: 1-286/286
Sequence Identity: 37% (111 aa)

YVAERVVGTGSFGIVFQAKCLETGETVAIKKVLQ---DKRYK---NRELQIMRLLDHPSIVSLKHCFFSTTDKDELYLNLVLEYVPETVYRIAKHYNRMN
|    .|| || | |.  .  |||. ||||| .    |.  |    ||. . . | |. ||.|.  |     | .|.  || ||.  ||  . ..   . 
YEKLGKVGEGSYGVVMKCRNKETGQIVAIKKFKESEDDPMVKKIAMREIKMLKQLKHENIVNLIEVF---RRKRKLH--LVFEYCDHTVLHELEE---YP

QRMPLLYVKLYTYQICRALTYIHGGMGVCHRDIKPQNLLVNPHTHQLKLCDFGSAKVLV-KGEPNISYICSRYYRAPELIFGATDYTTAIDIWSTGCVLA
.  .   |. |..||..|. . |  . . |||||| |.|..|.  |.|||||| |. |  .||    |   | ||||||  | |.| ...|||. |||.|
NGVDEHVVRKYMWQILKAINFCH-KHNCIHRDIKPENILITPKNGQVKLCDFGFARMLAKPGEIYTDYVATRWYRAPELLVGDTQYGKPVDIWAIGCVMA

ELLLGQPLFPGESGVDQLVEIIKVLG--TPTREEIKCMNPNYTEFKFPQIK-AHPWHKVFHKRMPPEAVDLVSRLLQYSPSLRCNALEALVHPFF
|.. ||||.||.| .|||  |.|.||  .|  .||  .|| .   |||.|.   |  | . .   ..| |..  .|. .|. | .. ... ||.|
EMIDGQPLWPGQSDIDQLYHIQKCLGPLIPRHQEIFSKNPFFHGMKFPEIEHMEPLEKRYPNKSNKKALDFMKKCLHMDPDERMTCEQLMHHPYF
Kinase GSK_b.AA CDK7 145-328 40 9.2e-62 163.07 In-house 104-288 (288) Show / Hide 
Range on Protein: 145-328
Range on HMM: 104-288/288
Sequence Identity: 40% (77 aa)

VKLYTYQICRALTYIHGGMGVCHRDIKPQNLLVNPHTHQLKLCDFGSAKVLVKGEPNISY---ICSRYYRAPELIFGATDYTTAIDIWSTGCVLAELLLG
.| |. .. . | | |    . |||.|| |||.|.   |||. ||| |.    | ||  |   .  |.|||||| |||  |.|..|.|| ||..|||.| 
IKAYMMMTLQGLEYCHRNW-ILHRDLKPNNLLMNENG-QLKIADFGLARFY--GSPNRIYTHQVVTRWYRAPELLFGARHYGTGVDMWSVGCIFAELMLR

QPLFPGESGVDQLVEIIKVLGTPTREE---IKCMNPNYTEFK-FPQIKAHPWHKVFHKRMPPEAVDLVSRLLQYSPSLRCNALEALVHPFF
 | .||.| .|||. | . ||||| ||   . || ..| .|| ||     | ...|    . ...||.....   |. |. . ..| .|.|
VPYLPGDSDIDQLTRIFQTLGTPTEEEWPNMCCM-MDYIKFKDFPGYSRTPLRHIFT-AASDDLLDLMCGMWTMNPCKRWTCTQCLKMPYF
Kinase GSK_b.AA ERK7 44-328 31 7.2e-59 199.86 In-house 1-292 (292) Show / Hide 
Range on Protein: 44-328
Range on HMM: 1-292/292
Sequence Identity: 31% (95 aa)

YVAERVVGTGSFGIVFQAKCLETGETVAIKKVLQ------DKRYKNRELQIMRLLD-HPSIVSLKHCFFSTTDKDELYLNLVLEYVPETVYRIAKHYNRM
|  .. .| | .|||  | .  |...||.||.        |     ||  ... .. || |..|   .    |.| .|  || |.       . .. | .
YEIRKRLGKGAYGIVWKAYDKRTKQVVALKKIFDAFRNQTDAQRTFREIMFLQEFHCHPNIIRLINVIRADNDRD-IY--LVFEFMETDLHAVIRKGNIL

NQRMPLLYVKLYTYQICRALTYIHGGMGVCHRDIKPQNLLVNPHTHQLKLCDFGSAKVLVKGE------PNIS-YICSRYYRAPELIFGATDYTTAIDIW
        ..   ||. ||. |.| |  | |||.|| |.|..   . .|.|||| |  . . |      | .  |.  | |||||   |.. || ..| |
KD----IHKQYIMYQLLRAIKYMHSGN-VIHRDLKPSNILLDSECM-VKVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMW

STGCVLAELLLGQPLFPGESGVDQLVEIIKVLGTPTREEIKCMNPNYTEF---KFPQIKAHPWHKVFHKRMPPEAVDLVSRLLQYSPSLRCNALEALVHP
| ||.|.|.| |.|.||| | ..|.  |..... ||.|.|. ....|      . .| | .. ....    ...|.||. |||.. |  |  | .|| ||
SIGCILGEMLRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMP-QCCDDAIDLLKRLLVFNPKKRLTAEQALQHP

FF
. 
YV
Kinase GSK_b.AA ERK 149-328 36 1.3e-57 197.72 In-house 114-307 (307) Show / Hide 
Range on Protein: 149-328
Range on HMM: 114-307/307
Sequence Identity: 36% (72 aa)

TYQICRALTYIHGGMGVCHRDIKPQNLLVNPHTHQLKLCDFGSAKVLVKGEPNI---------SYICSRYYRAPELIFGATDYTTAIDIWSTGCVLAELL
.||| ..| |||   .| |||.|| |.|||    .|| |||| | ..  .  ..          |. .|.|||||..  ...||.|.||||.|| .||.|
MYQILCGLKYIHSA-NVIHRDLKPSNILVNSNC-DLKICDFGLARCFDASYQENHECNQNFMTEYVATRWYRAPEIMLSWQKYTKAMDIWSCGCIFAEML

LGQPLFPGESGVDQLVEIIKVLGTP-TREEIKCM-NPNYTEF--KFPQ--IKAHPWHKVFHKRMP--PEAVDLVSRLLQYSPSLRCNALEALVHPFF
 ..|||||.. |.|. .|....||| . |....  ..|. ..  ..|   ... || ..| .. .  |.|.|| ...|.  |. | .. |.| ||.|
GRKPLFPGKDYVHQINRIFQIIGTPHSEEDLQYICSENAWKYIKNLPNPVRPPKPWENIF-PNANCNPQAIDLLEKMLVFDPDKRITVEECLEHPYF
Kinase GSK_b.AA TyrKc 44-328 22 2.7e-14 8.4 SMART 1-280 (280) Show / Hide 
Range on Protein: 44-328
Range on HMM: 1-280/280
Sequence Identity: 22% (70 aa)

YVAERVVGTGSFGIVFQAKCLETGETVAIKKVLQDKRYKN--RELQIMRLL--DHPSIVSLKHCFFSTTDK------DELYLNLVLEYVPETVYRIAKHY
 . ... | | ||.|....     ..||.|..  |.  .   ||..||. |  .|| || |  .   |...      . |.  .|.||.|   .   |.|
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGV--CTQQGRNFMYIEPLM--IVMEYMP---HGDLKDY

NRMNQR-MPLLYVKLYTYQICRALTYIHGGMGVCHRDIKPQNLLVNPHTHQLKLCDFGSAKVLVKG----EPNISYI-----CSR-----YYRAPELIFG
 | ...  ..     . .||..   |.|   .. |||.   | ||.    . | .||| .. .  .    |    |      ...        ||| |  
LRKHRPKLCMKDLLSFCWQIACGMEYLHSK-NCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI--

ATD-YTTAIDIWSTGCVLAELL-LGQPLFPGE----SGVDQLVEIIKVLGTPTREEIKCMNPNYTEFKFPQIKAHPWHKVFHKRMPPEAVDLVSRLLQYS
 .  .||. |.|| | .. |.. .||.  ||.       ....| .|  . . . .  .  |                  |  ..|.|  .. ..  .. 
NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY--P-MS---------------F-VCCPDEMYQIMKQCWHED

PSLRCNALEALVHPFF
|. |..  |   | .|
PEDRPTFSEI--HECF
Kinase GSK_b.AA CDK7 44-75 40 4.5e-10 22.58 In-house 1-32 (288) Show / Hide 
Range on Protein: 44-75
Range on HMM: 1-32/288
Sequence Identity: 40% (13 aa)

YVAERVVGTGSFGIVFQAKCLETGETVAIKKV
|  .. .| | |. |. |  ..||. |||||.
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKI
Kinase GSK_b.AA Pkinase_Tyr 44-123 26 1.4e-09 33.05 Pfam 1-90 (270) Show / Hide 
Range on Protein: 44-123
Range on HMM: 1-90/270
Sequence Identity: 26% (25 aa)

YVAERVVGTGSFGIVFQAKCL----ETGETVAIKKVLQDKRYKN-------RELQIMRLL-DHPSIVSLKHCFFSTTDKDEL-YLNLVLEYVP
 .  .. | |.|| |.....     .|. .||.|.. ..   ..       ||..||. | .|| ||.|  .     |..|  .. .|.||.|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCT---DQGEPNQIYIVMEYMP
Kinase GSK_b.AA ERK 44-102 29 2.3e-07 23.7 In-house 1-71 (307) Show / Hide 
Range on Protein: 44-102
Range on HMM: 1-71/307
Sequence Identity: 29% (21 aa)

YVAERVVGTGSFGIVFQAKCLE-----TGETVAIKKV---LQDKRYKN---RELQIMRLLD-HPSIVSLKH
|     .| |..|.|. |.  |     ||..|||||.     ...| .   ||. ..|... |. |..|..
YQIIKQIGHGAYGVVCSAIDKEYCFDETGQKVAIKKIENAFDHPIYCKRTLREIKLLRHFKGHENIICLFD