Gene DYRKP-1 (S.moellendorffii)

DYRKP-1

Species: S.moellendorffii
Alias: DYRKP-1
External Links:
Annotation:

Classification

Group: CMGC
Family: DYRK
Subfamily: DYRKP

Sequence

Name Sequence Type Origin Length Description Download
DYRKP-1.AA Protein None 1099 None Fasta, JSON
DYRKP-1.NA RNA None 3300 None Fasta, JSON
DYRKP-1.kin_dom Protein Kinase Domain None 923 None Fasta, JSON

Protein domain

Protein domains of DYRKP-1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase DYRKP-1.AA DyrkP 788-1033 63 3e-140 465.02 In-house 1-246 (323) Show / Hide 
Range on Protein: 788-1033
Range on HMM: 1-246/323
Sequence Identity: 63% (157 aa)

YHVTEFLGAAAFSKAIQAHDLFTGMDVCMKIIKNNKDFFDQSLDEIKLLKYINKHDPADKYHILRLYDYFYHREHLFIVCELLRANLYEFHKYNRDSGGE
| . |.||.||||||||  |. |.  .||||| ||||.||||.||||||.|||     |   .|| ||||||.|||||. |||. ||||| |.||.    
YQIMEYLGSAAFSKAIQCQDKQTNQMMCMKIIENNKDYFDQSIDEIKLLRYINYNGDVDEKNVLRYYDYFYHKEHLFIITELLKDNLYEFYKFNRENEQQ

VYFTMPRLQSITRQCLEALEFLHGLGLIHCDLKPENILVKSYSRCEVKVIDLGSSCFQSDHLCSYVQSRSYRAPEVILGLPYDQKIDIWSLGCILAELCS
 |||. ||| || | | ||...| | ||||||||||||.|||..|.||.|| |||||  ||| ||||||||||||||.|  || .||.||||||||||  
RYFTVGRLQKITQQILIALDYIHSLRLIHCDLKPENILMKSYPKCQVKIIDFGSSCFIHDHLSSYVQSRSYRAPEVIIGCKYDYRIDMWSLGCILAELWT

GNVLFQNDSLATLLARVVGIIGPLDPEMVARGRESYKFLTKNGKLY
|||||||| .  |||||.|||||.   |.  ||    | |..  ||
GNVLFQNDNIQGLLARVIGIIGPFPEWMMQEGRLVQNFFTRKRLLY
Kinase DYRKP-1.AA DYRK 788-1090 40 2.3e-128 432.75 In-house 1-320 (320) Show / Hide 
Range on Protein: 788-1090
Range on HMM: 1-320/320
Sequence Identity: 40% (130 aa)

YHVTEFLGAAAFSKAIQAHDLFTGMDVCMKIIKNNKDFFDQSLDEIKLLKYINKHDPADKYHILRLYDYFYHREHLFIVCELLRANLYEFHKYNRDSGGE
| . |..|   |.. ... |  |. .|..|||.|||.|..|...|||.|.|.|..|| ||||....|||||||.||.|| |||  ||||| | |.  |. 
YEILEYIGKGSFGQVVKCWDHKTNEMVAIKIIRNNKRFHRQAQIEIKILEYLNQQDPDDKYHCVHMYDYFYHRNHLCIVFELLSMNLYEFLKNNHFQGF-

VYFTMPRLQSITRQCLEALEFLHGL-GLIHCDLKPENILVKSY-SRCEVKVIDLGSSCFQSDHLCSYVQSRSYRAPEVILGLPYDQKIDIWSLGCILAEL
  |.. . .....| |..| ||| .  .||||||||||..|.  .....|||| ||||| .... .|.||| |||||||||.||. .||.||||||||||
--FSLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENIMLKQPRNKSTIKVIDFGSSCFEHQRIYTYIQSRFYRAPEVILGCPYCYAIDMWSLGCILAEL

CSGNVLFQNDSLATLLARVVGIIGPLDPEMVARG--RESYKFLTK----------NGKL------YERNQETSRMEYLIPKKTTLAHRLPMGDQGFLEFV
  |..||....   .||... ..|.  ..|.  |  |   || ..          ...       . ....|.| ....|... . .|.   |. |. |.
FTGWPLFPGENEYDQLACIMEVLGMPPKWMIDKGRCRRKHKFFDCFMYCECDEWTKQNKITDHYMTPKCHPTKRGQRRPPGRRNWDPRHQCDDHQFKDFI

AFLLQINPKNRPSAAEALKHPWL
  .||..|..|.....||.|||.
KKCLQWDPHKRITPSQALQHPWF
Kinase DYRKP-1.AA CMGC 788-1090 18 3.1e-89 293.29 In-house 1-513 (513) Show / Hide 
Range on Protein: 788-1090
Range on HMM: 1-513/513
Sequence Identity: 18% (96 aa)

YHVTEFLGAAAFSKAIQAHD--------------LFTGMDVCMKIIKNNKDFFDQSL-------------DEIKLLKYIN-KHDPAD-----------KY
|.. . .|  ....  .. |                |.  | .|.|||.. . .| .             .|||.||..| .||| .           . 
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDP-NWQRRDDPDNKHHN

HILRLYDYFYHRE-----------------HLFIVCELLRANLYEFHKYNR--DSG-GEVYFTMPR------------LQSIT------RQCLEALE--F
.|..|||.|||..                 ||..| |..  .||.. | |.  . | . ....                ....      .| |..|.  .
NIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKY

LHGLG--LIHCDLKPENILVKS------------------YSRCEVKVIDLGSSCFQSDH------------------------LCSYVQSRSYRAPEVI
.|  .   ||.||||||||. .                  ... ..|..| |.... ..|                        . .||..| |||||..
CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEIL

LGLP----------YDQKIDIWSLGCILAELCSG--------NVLFQNDSL-----------ATLLARVVGIIGPLDPEMVARGR--------ES-----
|| .          |...||.||.|||.||.  |          ||. .|               |.. . ..|. . .|  .|.        |      
LGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPT-WMIQKGKRHFNFCKHEEEWPNM

YK------------------FLTKNGKLYERNQETSRMEYLIPKK------------------------TTLAHRLP--------MGDQGFLEFVAFLLQ
 |                  .... ...| ..  .  . . .| |                         . ... .        . |. .....  .||
IKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSH-KFNHQFKRKCCDPQAIDLLKKMLQ

INPKNRPSAAEALKHPWL
..|..|..|..||.||..
YDPDKRITAEQALQHPYF
Kinase DYRKP-1.AA DYRK2 788-992 43 3.4e-75 243.89 In-house 1-202 (318) Show / Hide 
Range on Protein: 788-992
Range on HMM: 1-202/318
Sequence Identity: 43% (90 aa)

YHVTEFLGAAAFSKAIQAHDLFTGMDVCMKIIKNNKDFFDQSLDEIKLLKYINKHDPADKYHILRLYDYFYHREHLFIVCELLRANLYEFHKYNRDSGGE
| . |..|   |   . . |  |.  |. |.| | | |  | . ||. |..| ..|.   . . .. |||| | |..|. |||  ||||. | |   |  
YEILEVIGKGSFGQVVKCYDHKTKQHVAIKMIRNKKRFHNQAYEEIRILHHIRRQDKDNTMNCVHMLDYFYFRNHHCITFELLSMNLYEYIKKNHFQG--

VYFTMPRLQSITRQCLEALEFLHGLGLIHCDLKPENILVKSYSRCEVKVIDLGSSCFQSD-HLCSYVQSRSYRAPEVILGLPYDQKIDIWSLGCILAELC
  |..      ... |..|.|||   .||||||||||| |.  |  .|||| |||||    ..  |.||| |||||||||..|.  ||.||.|||.||| 
--FSLQLVRRFAHSILQCLRFLHKNNIIHCDLKPENILLKQWNRSGIKVIDFGSSCFEHQYRIYTYIQSRFYRAPEVILGGKYGMAIDMWSFGCIMAELY

SGNVLF
.|  ||
TGYPLF
Kinase DYRKP-1.AA S_TKc 788-1090 24 3e-71 243.92 SMART 1-231 (231) Show / Hide 
Range on Protein: 788-1090
Range on HMM: 1-231/231
Sequence Identity: 24% (78 aa)

YHVTEFLGAAAFSKAIQAHDLFTGMDVCMKIIKNNKDFFDQSLDEIKLLKYINKHDPADKYHILRLYDYFYHREHLFIVCELLRA---NLYEFHKYNRDS
|.. . .|  ||.|  ....  ||  | .||||      .. . ||..||        .  .| .|||.|.. .||..| |..     .|... | ..  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-------HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH

GGEVYFTMPRLQSITRQCLEALEFLHGLGLIHCDLKPENILVKSYSRCEVKVIDLGSSCFQSDHLCSYVQSRSYRAPEVILGLPYDQ-KIDIWSLGCILA
|. ..|.  . .....| ..|||..| .| ||.||||||||. .    ..|..| |....      ... .. |.||||.   .|.  |.|.||.||||.
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

ELCSGNVLFQNDSLATLLARVVGIIGPLDPEMVARGRESYKFLTKNGKLYERNQETSRMEYLIPKKTTLAHRLPMGDQGFLEFVAFLLQINPKNRPSAAE
|...|  .|.   ..... ...                                                      .. ...|.  .|| .|..||.| |
EMLCGYPPFP--QMQMMFKKIG------------------------------------------------------SPEAKDFIRKCLQKDPEKRPTA-E

ALK-------HPWL
||.       |||.
ALQDEWDIKCHPWF
Kinase DYRKP-1.AA DYRK1 788-1052 36 1.8e-63 217.15 In-house 1-265 (321) Show / Hide 
Range on Protein: 788-1052
Range on HMM: 1-265/321
Sequence Identity: 36% (98 aa)

YHVTEFLGAAAFSKAIQAHDLFTGMDVCMKIIKNNKDFFDQSLDEIKLLKYINKHDPADKYHILRLYDYFYHREHLFIVCELLRANLYEFHKYNRDSGGE
| .   .|  .| . ..|.|  .   | .||||| | |..| . ||.||  .||||. .||.|..|   | .|.|| .| |||  |||.  .     |  
YEIDSLIGKGSFGQVVKAYDHQEQEYVAIKIIKNKKPFYNQAQIEIRLLELMNKHDKEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVS

VYFTMPRLQSITRQCLEALEFLHG--LGLIHCDLKPENILVKSYSRCEVKVIDLGSSCFQSDHLCSYVQSRSYRAPEVILGLPYDQKIDIWSLGCILAEL
.  |    . . .| . || |.    | .|||||||||||.    |  .|.|| ||||   . .  |.||| ||.|||.||..|| .||.||||||| |.
LNLT----RKFAQQMCTALLFMSTPELDIIHCDLKPENILLCNPKRSAIKIIDFGSSCQLGQRIYQYIQSRFYRSPEVLLGIEYDMAIDMWSLGCILVEM

CSGNVLFQNDSLATLLARVVGIIGPLDPEMVARGRESYKFLTK--NGKLYERNQETSRMEYLIPKKTTL
  |  ||   .    . ..| ..|    .|. ..  . |. .|  ..  | . ..  . .|  | .  |
HTGEPLFSGSNEVDQMNKIVEVLGMPPKHMIDQAPKAHKYFEKDPDNTWYCKKTRDKKKHYKEPCTRKL
Kinase DYRKP-1.AA Pkinase 788-1090 25 4.9e-58 203.91 Pfam 1-293 (293) Show / Hide 
Range on Protein: 788-1090
Range on HMM: 1-293/293
Sequence Identity: 25% (83 aa)

YHVTEFLGAAAFSKAIQAHDLFTGMDVCMKIIKNNKDFFDQ---SLD--EIKLLKYINKHDPADKYHILRLYDYFYHREHLFIVCELLRANLYEFHKYN-
||. . .|. .|..  ..|.  ||  |..||||  ..  ..    .   ||...| . .|.     .|.||||.|. . |. .| |...  ||       
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHP-----NIVRLYDWFEDKDHIYMVMEYCEGGLY-VMDLFD

---RDSGGEVYFTMPRLQSITRQCLEALEFLHGLGLIHCDLKPENILVKSYSRCEV----KVIDLGSSC---FQSDHLCSYVQSRSYRAPEVIL-GLPYD
   ....| .||..  .... .| |..||..|  | ||.||||||||..  .....    |..| |...     .... ... .. |.|||||. | .|.
YISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID--NNGHIDACVKICDFGLAKQFDY-NNSMTTFCGTPWYMAPEVIRGGQYYG

QKIDIWSLGCILAELCSGNVLFQND----SLATLLARVVGIIGPLDPEMVA---RGRESYKFLTKNGKLYERNQETSRMEYLIPKKTTLAHRLPMGDQGF
.|.|.||.||||.|...|. .|...    . .. ..... | ||  ..      ... .. | .   .                  . .  . .  .. .
PKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H------------------F-HWTF-HNWSEEC

LEFVAFLLQINPKNRPSAAEALKHPWL
..|.  .|. .|| ||.|...|.|||.
KDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase DYRKP-1.AA YAK 788-985 40 1.1e-56 190.93 In-house 1-198 (347) Show / Hide 
Range on Protein: 788-985
Range on HMM: 1-198/347
Sequence Identity: 40% (82 aa)

YHVTEFLGAAAFSKAIQAHDLFTGMDVCMKIIKNNKDFFDQSLDEIKLLKYIN-KHDPADKY---HILRLYDYFYHREHLFIVCELLRANLYEFHKYNRD
| |   ||   |   .    . |   .  |.|||   .| |.  ||..|.  | .||| .|    ||||.||.| |. |. .| |.|  ||||. | |. 
YIVLDMLGQGTFGQVVKCQNCDTNELFAVKVIKNRQAYFQQAKNEIQILRVLNQQHDPNNKNYQKHILRMYDFFVHKNHFCLVFEMLSNNLYEYLKQNKF

SGGEVYFTMPRLQSITRQCLEALEFLHGLGLIHCDLKPENILVKSYSRCEVKVIDLGSSCFQSDHLCSYVQSRSYRAPEVILGLPYDQKIDIWSLGCILA
 |    | .   .  | | |...  |    .||||||||||. .   . |.|.|| ||||     .  |.|.| ||.||.|.. .|   || ||||||.|
CG----FSFQLIRQWTKQILDGMCVLENKQIIHCDLKPENIMLCKPNKPEIKIIDFGSSCQEKKMVYTYIQQRHYRSPEIIVWMIYCTSIDMWSLGCIVA

EL
||
EL
Kinase DYRKP-1.AA HIPK 788-996 41 3.7e-55 171.92 In-house 1-207 (329) Show / Hide 
Range on Protein: 788-996
Range on HMM: 1-207/329
Sequence Identity: 41% (88 aa)

YHVTEFLGAAAFSKAIQAHDLFTGMDVCMKIIKNNKDFFDQSLDEIKLLKYINKHDPADKYHILRLYDYFYHREHLFIVCELLRANLYEFHKYNRDSGGE
| | ||||   | . . .    |.  | .||.||.  .  |   |...|. . . . || ||..| |..| |..| ..| |.|  |||.| | |. .   
YEVLEFLGRGTFGQVVKCWKRGTNEMVAIKILKNHPYYARQGQIEVSILHCLSQEN-ADEYHFVRAYECFHHKNHTCLVFEMLEQNLYDFQKQNKFMP--

VYFTMPRLQSITRQCLEALEFLHGLGLIHCDLKPENILVKSYSRC--EVKVIDLGSSCFQSDHLCS-YVQSRSYRAPEVILGLPYDQKIDIWSLGCILAE
    .  .  |. | | ||  |  ||||| |||||||.    .||   ||||| ||    |.  |. |.||| |||||.|||||. ...|.|||||..||
--LPLKHIRPILQQVLTALMKLKELGLIHADLKPENIMLVDPTRCPYRVKVIDFGSASHVSKVVCNTYLQSRYYRAPEIILGLPFCENHDMWSLGCVIAE

LCSGNVLFQNDS
|  |  |. . .
LFLGWPLYPGAD
Kinase DYRKP-1.AA PRP4 788-992 37 9.6e-43 148.33 In-house 1-205 (320) Show / Hide 
Range on Protein: 788-992
Range on HMM: 1-205/320
Sequence Identity: 37% (78 aa)

YHVTEFLGAAAFSKAIQAHDLFTGM-DVCMKIIKNNKDFFDQSLDEIKLLKYINKH--DPADKYHILRLYDYFYHREHLFIVCELLRANLYE-FHKYNRD
| |  . |.  ||  ... |.  |  .|  ||| ||    .  | |.  |. .|    |. ||.|..|... |.|| |. .| | .  || |   || .|
YRVYGYCGQGVFSNVCRCRDQTRGNEMVAIKIIRNNEIMHKTGLRELEILQKLNDAPTDKNDKFHCVRMFRHFNHRQHMCLVFECMSMNLREVLKKYGKD

SGGEVYFTMPRLQSITRQCLEALEFLHGLGLIHCDLKPENILVKSYSRCEVKVIDLGS-SCFQSDHLCSYVQSRSYRAPEVILGLPYDQKIDIWSLGCIL
 |    . .    | ..| . ||  |  .. .| |.|| |||| . |.   | .| || |  .   .  | .|| |||||.|.| |||  ||.|| || |
VG----LHLKAVRSYAQQLFLALKHLKKCNILHADIKPDNILV-NESKNTLKMCDFGSASHIHENEITPYLVSRFYRAPEIIIGHPYDYQIDMWSVGCTL

AELCSGNVLF
.||  | ..|
YELYTGKIMF
Kinase DYRKP-1.AA RCK 788-992 29 3.3e-36 112.17 In-house 1-214 (298) Show / Hide 
Range on Protein: 788-992
Range on HMM: 1-214/298
Sequence Identity: 29% (65 aa)

YHVTEFLGAAAFSKAIQAHDLFTGMDVCMKIIKNNKDFFD----QSLDEIKLLKYINKHDPADKYHILRLYDYFYHRE--HLFIVCELLRANLYEFHKYN
| ... ||. ...  . | .. ||  | .|  |  . | .    ..| ||| |. .| |.     .|. |.. .....  .|..|.|..  |||.. |  
YQIIKQLGDGTYGCVMKAQNKETGEIVAIKKMK--QKFYSWEECMNLREIKSLRKLNPHP-----NIIKLKEVIRDNDTYQLYFVFEYMDMNLYQMMKDF

RDSGGEVYFTMPR--LQSITRQCLEALEFLHGLGLIHCDLKPENILVKS-------YSRCEVKVIDLGSS-CFQSDH-LCSYVQSRSYRAPEVILGL-PY
 .  .. |.. .   . .|  | | .|...|  |  | |||||||....        ..  .|..| |.. ...| .    || .| |||||..|    |
KE--RRKYLPENQRSIKNIMYQILQGLAHMHKHGFFHRDLKPENIMCTGSQQYFEDQDQDHIKIADFGLCREIRSKPPYTDYVSTRWYRAPECLLRCTYY

DQKIDIWSLGCILAELCSGNVLF
. ..|||..||| .|| . . ||
NSPMDIWAVGCIMYELYMLRPLF
Kinase DYRKP-1.AA CLK 788-925 31 5.1e-32 92.73 In-house 1-146 (350) Show / Hide 
Range on Protein: 788-925
Range on HMM: 1-146/350
Sequence Identity: 31% (47 aa)

YHVTEFLGAAAFSKAIQAHDLFTG-MDVCMKIIKNNKDFFDQSLDEIK-LLKYINKH-DPADKYH--ILRLYDYFYH-REHLFIVCELLRANLYEFHKYN
| ..  ||  .|.|  .  |   |   |  |||.| . . ...  ||.  .| ||.  ||  ||   .....|.| .   |  || ||.  ..|.| | |
YEIVCTLGEGTFGKVVECWDHKNGKKYVALKIIRNVEKYREAAWVEINQIMKKINEKHDPNNKYWEHCWKMNDWFDYGHGHICIVFELYGLSIYDFMKSN

R---DSGGEVYFTMPRLQSITRQCLEALEFLHGLGLIHCDLKPENIL
.       .  . .   .....| .||..||| ..|.| |||||||.
NSKMPN-KYIPYPIDHIRHMAYQLCEAVKFLHDMKLTHTDLKPENIC
Kinase DYRKP-1.AA CLK 932-993 50 2.9e-25 72.1 In-house 184-248 (350) Show / Hide 
Range on Protein: 932-993
Range on HMM: 184-248/350
Sequence Identity: 50% (33 aa)

CEVKVIDLGSSC---FQSDHLCSYVQSRSYRAPEVILGLPYDQKIDIWSLGCILAELCSGNVLFQ
....||| ||     |   |    |..| ||||||||||.. |. |.|| |||| || .|  |||
THICVIDFGSATKIRFDHEHHSTIVSTRHYRAPEVILGLGWSQPCDVWSIGCILFELYTGFTLFQ
Kinase DYRKP-1.AA DyrkP 1035-1090 42 2e-16 49.97 In-house 268-323 (323) Show / Hide 
Range on Protein: 1035-1090
Range on HMM: 268-323/323
Sequence Identity: 42% (24 aa)

RNQETSRMEYLIPKKTTLAHRLPMGDQGFLEFVAFLLQINPKNRPSAAEALKHPWL
. | | ..  |.||.  |  ||   |  |..||  .|||    ||.| |||.|||.
QRQKTGKIQILVPKHSNLRARLRTDDHMFIDFVRQCLQIDFTRRPTAKEALQHPWF
Kinase DYRKP-1.AA TyrKc 788-1090 18 2.5e-09 -71.7 SMART 1-280 (280) Show / Hide 
Range on Protein: 788-1090
Range on HMM: 1-280/280
Sequence Identity: 18% (63 aa)

YHVTEFLGAAAFSKAIQAHDLFTGMDVCMKIIKNNKDFFDQSLDEIKLLKYI-NKHDPADKYHILRLYDYFYHR-------EHLFIVCELLRANLYEFHK
 .  . ||  || .  ...     ..|  | .|...      ..|..... .  .|.     .|.||| .  .        | |.|| |.  . .   ..
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHP-----NIVRLYGVCTQQGRNFMYIEPLMIVMEY--MPHGDLKD

YNRDSGGEVYFTMPRLQSITRQCLEALEFLHGLGLIHCDLKPENILVKSYSRCEVKVIDLGSSCFQSDH-LC----SYVQSR---SYR--------APEV
| |.....  ..|. | |.  |  .  |.||  ..|| ||   |.||.  ..  ||. | | | .  |.  .    .|  ..   . .        |||.
YLRKHRPK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVG--ENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPEC

ILGLPYDQKIDIWSLGCILAELCS-GNVLFQN-----DSLATLLARVVGIIGPLDPEM----VARGRESYKFLTKNGKLYERNQETSRMEYLIPKKTTLA
|    .  | |.|| |  . |... |     .      | . ....|     .  |.                                           
INYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS-------------------------------------

HRLPMGDQGFLEFVAFLLQI-------NPKNRPSAAEALKHPWL
         | .  . . ||       .|..||. .|   |  .
---------FVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase DYRKP-1.AA DYRK2 1046-1090 28 2.8e-08 22.68 In-house 273-318 (318) Show / Hide 
Range on Protein: 1046-1090
Range on HMM: 273-318/318
Sequence Identity: 28% (13 aa)

IPKKTTLAHRLP-MGDQGFLEFVAFLLQINPKNRPSAAEALKHPWL
.|  . ... |. ..|. |..|.   ..  |. | ....||||||.
PPGSKSWKSVLKGCEDENFIDFIKRCFEWDPSERMTPSQALKHPWI
Kinase DYRKP-1.AA RCK 1070-1090 42 1.9e-07 19.35 In-house 278-298 (298) Show / Hide 
Range on Protein: 1070-1090
Range on HMM: 278-298/298
Sequence Identity: 42% (9 aa)

LLQINPKNRPSAAEALKHPWL
.||..|. |..|..||.||  
MLQWDPQKRITAQQALQHPYF
Kinase DYRKP-1.AA YAK 1063-1090 39 7e-06 15.44 In-house 320-347 (347) Show / Hide 
Range on Protein: 1063-1090
Range on HMM: 320-347/347
Sequence Identity: 39% (11 aa)

FLEFVAFLLQINPKNRPSAAEALKHPWL
|. |.  ||| ||. | ..  | .|| .
FIDFINQLLQLNPRERWKPMQAMQHPFI
Kinase DYRKP-1.AA CLK 1070-1090 33 1.2e-05 12.07 In-house 330-350 (350) Show / Hide 
Range on Protein: 1070-1090
Range on HMM: 330-350/350
Sequence Identity: 33% (7 aa)

LLQINPKNRPSAAEALKHPWL
.| . |  |.....||.||. 
MLEYDPSKRITCKDALQHPFF
Kinase DYRKP-1.AA PRP4 1070-1090 47 0.000332 11.39 In-house 300-320 (320) Show / Hide 
Range on Protein: 1070-1090
Range on HMM: 300-320/320
Sequence Identity: 47% (10 aa)

LLQINPKNRPSAAEALKHPWL
.|.  ||.| .  |||||| .
CLMLDPKKRITCNEALKHPFI
Kinase DYRKP-1.AA DYRK1 1063-1090 32 0.01019 4.8 In-house 294-321 (321) Show / Hide 
Range on Protein: 1063-1090
Range on HMM: 294-321/321
Sequence Identity: 32% (9 aa)

FLEFVAFLLQINPKNRPSAAEALKHPWL
| . .  .|| .||.| .  .||.|...
FKDLIKRMLQYDPKQRITPYYALQHSFF
Kinase DYRKP-1.AA HIPK 1070-1090 28 0.070983 1.13 In-house 309-329 (329) Show / Hide 
Range on Protein: 1070-1090
Range on HMM: 309-329/329
Sequence Identity: 28% (6 aa)

LLQINPKNRPSAAEALKHPWL
.. .....| . .|||.||. 
MCTWDAHKRITPCEALNHPFV