Gene DYRK2_a (S.moellendorffii)

DYRK2_a

Species: S.moellendorffii
Alias: DYRK2_a
External Links:
Annotation:

Classification

Group: CMGC
Family: DYRK
Subfamily: DYRK2

Sequence

Name Sequence Type Origin Length Description Download
DYRK2_a.AA Protein None 439 None Fasta, JSON
DYRK2_a.NA RNA None 1320 None Fasta, JSON
DYRK2_a.kin_dom Protein Kinase Domain None 299 None Fasta, JSON

Protein domain

Protein domains of DYRK2_a.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase DYRK2_a.AA DYRK2 116-414 50 1.2e-166 546.29 In-house 1-318 (318) Show / Hide 
Range on Protein: 116-414
Range on HMM: 1-318/318
Sequence Identity: 50% (163 aa)

YEILGKLGRGSFGQVLKCTDHKYKVPRAIKIIRNKKQFTQQAFIEINLLEFLRNKAAEEGVDYNIVTIYESFEFRGHLCLSFAVHDISLFDMLKKNHFEG
||||  .|.||||||.||.|||.|   |||.||||| | .|| .||. |. .| .   .   .|.| . ..| ||.|.|. |   ...| . .||||| |
YEILEVIGKGSFGQVVKCYDHKTKQHVAIKMIRNKKRFHNQAYEEIRILHHIRRQDKDN--TMNCVHMLDYFYFRNHHCITFELLSMNLYEYIKKNHFQG

FNLSLVKCFARQVLVSLQFLHRARIIHGDLKPENILLQQPASPKIKLIDFGSSCFEHE-RIYTYIQSRFYRAPEVILGLPYDMMIDVWSFACILAELFTG
|.|.||  ||...| .|.|||. .|||.||||||||| |.    ||.||||||||||. |||||||||||||||||||..|.| || ||| ||.|||.||
FSLQLVRRFAHSILQCLRFLHKNNIIHCDLKPENILLKQWNRSGIKVIDFGSSCFEHQYRIYTYIQSRFYRAPEVILGGKYGMAIDMWSFGCIMAELYTG

YPLFPGEDEVEQLAYMMEVLGTPPLSLISQA-----KRKKMFFD--------------SDNKPRIVPNSSGTRHFPSTKDLRMVVG-CSDKSFVNFLSCC
|||||||.|..|.|.|||||| || ......     .|.|.||.              |.  |....|. | |  | .|.. .|.  | |..|..|.. |
YPLFPGENENDQFACMMEVLGMPPKKFFDTWFYIHCFRRKYFFNSHCFEWYCTFMTDHSMEIPKHYKNRHGKRRPPGSKSWKSVLKGCEDENFIDFIKRC

LKWDKEQRMTPQQLLKHEWI
..|| ..||||.| |||.||
FEWDPSERMTPSQALKHPWI
Kinase DYRK2_a.AA DYRK 116-414 50 1.7e-153 516.26 In-house 1-320 (320) Show / Hide 
Range on Protein: 116-414
Range on HMM: 1-320/320
Sequence Identity: 50% (163 aa)

YEILGKLGRGSFGQVLKCTDHKYKVPRAIKIIRNKKQFTQQAFIEINLLEFLRNKAAEEGVDYNIVTIYESFEFRGHLCLSFAVHDISLFDMLKKNHFEG
||||. .|.|||||| ||.||| .   |||||||.| | .|| |||..|| |...   .   |..| .|..| .|.|||. |   ...|.. ||.||| |
YEILEYIGKGSFGQVVKCWDHKTNEMVAIKIIRNNKRFHRQAQIEIKILEYLNQQ--DPDDKYHCVHMYDYFYHRNHLCIVFELLSMNLYEFLKNNHFQG

F-NLSLVKCFARQVLVSLQFLHRA-RIIHGDLKPENILLQQP-ASPKIKLIDFGSSCFEHERIYTYIQSRFYRAPEVILGLPYDMMIDVWSFACILAELF
| .|.||. ||.|.|..| |||.  .|||.|||||||.|.||   . ||.||||||||||.|||||||||||||||||||.||.. ||.||. |||||||
FFSLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENIMLKQPRNKSTIKVIDFGSSCFEHQRIYTYIQSRFYRAPEVILGCPYCYAIDMWSLGCILAELF

TGYPLFPGEDEVEQLAYMMEVLGTPPLSLISQA--KRKKMFFDS------------DN------KPRIVPNSSGTRHFPSTKDLRMVVGCSDKSFVNFLS
||.||||||.|..|||..||||| ||  .|...  .||. |||.            ..       |. .|.. |.|  |..... ..  | |. |..|. 
TGWPLFPGENEYDQLACIMEVLGMPPKWMIDKGRCRRKHKFFDCFMYCECDEWTKQNKITDHYMTPKCHPTKRGQRRPPGRRNWDPRHQCDDHQFKDFIK

CCLKWDKEQRMTPQQLLKHEWI
 ||.|| ..|.||.| |.| |.
KCLQWDPHKRITPSQALQHPWF
Kinase DYRK2_a.AA CMGC 116-414 20 1.4e-107 354.71 In-house 1-513 (513) Show / Hide 
Range on Protein: 116-414
Range on HMM: 1-513/513
Sequence Identity: 20% (107 aa)

YEILGKLGRGSFGQVLKCTD--------------HKYKVPRAIKIIRNKKQFTQQAF-------------IEINLLEFLRNKAAEEGV----------DY
|||..|.|.|..|.| ||.|              |...   |||.|.|.. .. ||               || .|. |...    .           . 
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDP-NWQRRDDPDNKHHN

NIVTIYESFEFRG-----------------HLCLSFAVHDISLFDMLKKNH--FEG------------------------FNLSLVKCFARQVLVSLQ--
|||..|..| ...                 ||.| |   | .|....|.|.  . |                        | . ... ...|.| .|   
NIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLK

FLHRAR--IIHGDLKPENILLQQP------------------ASPKIKLIDFGSSCFEHER------------------------IYTYIQSRFYRAPEV
..|...  ||| ||||||||. .                    . ..|..|||.....|..                        ...|...|.|||||.
YCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEI

ILGLP----------YDMMIDVWSFACILAELFTG--------YPLFPGEDE-----------VEQLAYMMEVLGTPPLSLISQAK-------RKKMFFD
.|| .          |.  ||.||..||.||..||        .|||||..|           ..||. ...|||||. ..|...|       ... ...
LLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPT-WMIQKGKRHFNFCKHEEEWPN

SDNKPRIVP-------------NSSGTRH-------FPSTK--DLRMVVGC-----------------------------------SDKSFVNFLSCCLK
  ..|.  .              |.. |.       ||  .  ... .. .                                    |. ....|. .|.
MIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQ

WDKEQRMTPQQLLKHEWI
.| ..|.|..| |.|...
YDPDKRITAEQALQHPYF
Kinase DYRK2_a.AA DYRK1 116-357 50 4.8e-93 315.43 In-house 1-242 (321) Show / Hide 
Range on Protein: 116-357
Range on HMM: 1-242/321
Sequence Identity: 50% (124 aa)

YEILGKLGRGSFGQVLKCTDHKYKVPRAIKIIRNKKQFTQQAFIEINLLEFLRNKAAEEGVDYNIVTIYESFEFRGHLCLSFAVHDISLFDMLKKNHFEG
|||   .|.|||||| |  ||. .   |||||.||| | .|| ||| |||.. .. .|.   |.||.. . | || |||| | .    |.|.|.  || |
YEIDSLIGKGSFGQVVKAYDHQEQEYVAIKIIKNKKPFYNQAQIEIRLLELMNKHDKEM--KYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRG

FNLSLVKCFARQVLVSLQFLH--RARIIHGDLKPENILLQQPASPKIKLIDFGSSCFEHERIYTYIQSRFYRAPEVILGLPYDMMIDVWSFACILAELFT
  | |.. ||.|.. .| |.      ||| |||||||||  |   .||.|||||||   .||| ||||||||.|||.||..||| ||.||  ||| |. |
VSLNLTRKFAQQMCTALLFMSTPELDIIHCDLKPENILLCNPKRSAIKIIDFGSSCQLGQRIYQYIQSRFYRSPEVLLGIEYDMAIDMWSLGCILVEMHT

GYPLFPGEDEVEQLAYMMEVLGTPPLSLISQAKRKKMFFDSDNK
| ||| | .||.|.  ..|||| ||  .| || . . .|. |..
GEPLFSGSNEVDQMNKIVEVLGMPPKHMIDQAPKAHKYFEKDPD
Kinase DYRK2_a.AA YAK 116-352 42 7.8e-88 298.11 In-house 1-239 (347) Show / Hide 
Range on Protein: 116-352
Range on HMM: 1-239/347
Sequence Identity: 42% (101 aa)

YEILGKLGRGSFGQVLKCTDHKYKVPRAIKIIRNKKQFTQQAFIEINLLEFLRNKAAEEGVDY--NIVTIYESFEFRGHLCLSFAVHDISLFDMLKKNHF
| .|  ||.| |||| ||     .   |.|.| |.  . |||  || .|. |  .   ..  |   |. .| .| .. |.|| |    ..|.. || | |
YIVLDMLGQGTFGQVVKCQNCDTNELFAVKVIKNRQAYFQQAKNEIQILRVLNQQHDPNNKNYQKHILRMYDFFVHKNHFCLVFEMLSNNLYEYLKQNKF

EGFNLSLVKCFARQVLVSLQFLHRARIIHGDLKPENILLQQPASPKIKLIDFGSSCFEHERIYTYIQSRFYRAPEVILGLPYDMMIDVWSFACILAELFT
 ||  .|.. .  |.| ..  |  ..||| |||||||.|..| .| ||.||||||| |   .|||||.|.||.||.|.. .|   || ||  ||.|||| 
CGFSFQLIRQWTKQILDGMCVLENKQIIHCDLKPENIMLCKPNKPEIKIIDFGSSCQEKKMVYTYIQQRHYRSPEIIVWMIYCTSIDMWSLGCIVAELFL

GYPLFPGEDEVEQLAYMMEVLGTPPLSLISQAKRKKMFF
| |.|||  | .|.    ..|| ||  .| | . |  .|
GLPIFPGNSEYNQIKRIIDMLGYPPSWMIDQGRFKNKYF
Kinase DYRK2_a.AA S_TKc 116-414 28 1.2e-81 278.44 SMART 1-231 (231) Show / Hide 
Range on Protein: 116-414
Range on HMM: 1-231/231
Sequence Identity: 28% (88 aa)

YEILGKLGRGSFGQVLKCTDHKYKVPRAIKIIRNKKQFTQQAFIEINLLEFLRNKAAEEGVDYNIVTIYESFEFRGHLCLSFAVHDI---SLFDMLKKNH
|||| |.|.|.||.| ||...| .   |||||.      ...  ||..|.             |||..|..|.  .||.. .   |    .|||..||. 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK---------HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRG

FEG----FNLSLVKCFARQVLVSLQFLHRARIIHGDLKPENILLQQPASPKIKLIDFGSSCFEHERIYTYIQSRFYRAPEVILGLPYDM-MIDVWSFACI
 .|    |.   ......|..  |...|. .||| ||||||||| .     ||..|||....     .|.. ...|.||||.   .|.   .|.||. ||
RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCI

LAELFTGYPLFPGEDEVEQLAYMMEVLGTPPLSLISQAKRKKMFFDSDNKPRIVPNSSGTRHFPSTKDLRMVVGCSDKSFVNFLSCCLKWDKEQRMTPQQ
|.|...|||.||      |.. |....|                                                .... .|.. ||..| |.|.|  .
LYEMLCGYPPFP------QMQMMFKKIG------------------------------------------------SPEAKDFIRKCLQKDPEKRPTA-E

LLK-------HEWI
.|.       |.|.
ALQDEWDIKCHPWF
Kinase DYRK2_a.AA HIPK 116-355 42 1.8e-68 214.57 In-house 1-240 (329) Show / Hide 
Range on Protein: 116-355
Range on HMM: 1-240/329
Sequence Identity: 42% (103 aa)

YEILGKLGRGSFGQVLKCTDHKYKVPRAIKIIRNKKQFTQQAFIEINLLEFLRNKAAEEGVDYNIVTIYESFEFRGHLCLSFAVHDISLFDMLKKNHFEG
||.|  |||| |||| ||  .  .   ||||..|   .  |  ||. .|. |... |.|   |..|  || |. . | || | . .  |.| .|.|.|  
YEVLEFLGRGTFGQVVKCWKRGTNEMVAIKILKNHPYYARQGQIEVSILHCLSQENADE---YHFVRAYECFHHKNHTCLVFEMLEQNLYDFQKQNKFMP

FNLSLVKCFARQVLVSLQFLHRARIIHGDLKPENILLQQPASP--KIKLIDFGS-SCFEHERIYTYIQSRFYRAPEVILGLPYDMMIDVWSFACILAELF
  |  ..    |||  |  |    .|| |||||||.|  |     ..| ||||| | . .    ||.|||.|||||.|||||.   .|.||  |..||||
LPLKHIRPILQQVLTALMKLKELGLIHADLKPENIMLVDPTRCPYRVKVIDFGSASHVSKVVCNTYLQSRYYRAPEIILGLPFCENHDMWSLGCVIAELF

TGYPLFPGEDEVEQLAYMMEVLGTPPLSLISQAKRKKMFFDSD
 | ||.|| || .|  |. .  . |  .|...| .|. ||| |
LGWPLYPGADEYDQIRYICQTQHLPHEHLLHAACKKHRFFDRD
Kinase DYRK2_a.AA Pkinase 116-414 26 4.7e-62 217.28 Pfam 1-293 (293) Show / Hide 
Range on Protein: 116-414
Range on HMM: 1-293/293
Sequence Identity: 26% (86 aa)

YEILGKLGRGSFGQVLKCTDHKYKVPRAIKIIRNKKQFTQQ---AFI--EINLLEFLRNKAAEEGVDYNIVTIYESFEFRGHLC--LSFAVHD---ISLF
|.|..|.|.||||.| ||.....    |.|||. ...  ..   ..   || ..  |.          |||..|..|| ..|..  . .. ..   ..||
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN--------HPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLF

DMLK---KNHFEGFNLSLVKCFARQVLVSLQFLHRARIIHGDLKPENILLQQPASP--KIKLIDFGSSCF---EHERIYTYIQSRFYRAPEVIL-GLPYD
|...   .. |  |    .|....|.|  |...|. .||| ||||||||. .   .  ..|..|||....     .  .|.  ...|.|||||. | .|.
DYISTWRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDYNNS-MTTFCGTPWYMAPEVIRGGQYYG

MMIDVWSFACILAELFTGYPLFPGE----DEVEQLAYMMEVLGTPPLSLISQAKRKKMFFDSDNKPRIVPNSSGTRHFPSTKDLRMVVGCSDKSFVNFLS
  .|.||. |||.|...|.|.|||.    . ..|.. . ...|.|. . ...  ..  ||     .               . .. .    ....  |..
PKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H-------------F-HWTF-HNWSEECKDFIK

CCLKWDKEQRMTPQQLLKHEWI
.||..| ..| |..|.|.|.|.
WCLCKDPKKRPTAEQILQHPWF
Kinase DYRK2_a.AA CLK 116-252 31 3.2e-49 145.33 In-house 1-147 (350) Show / Hide 
Range on Protein: 116-252
Range on HMM: 1-147/350
Sequence Identity: 31% (47 aa)

YEILGKLGRGSFGQVLKCTDHKY-KVPRAIKIIRNKKQFTQQAFIEIN-LLEFLRNKAAEEGVDY-NIVTIYESFEF-RGHLCLSFAVHDISLFDMLKKN
|||. .|| | || |..| |||. |   |.||||| .... .| .|||  .. . .|   ..    ... ....|..  || |..|     |..| .|.|
YEIVCTLGEGTFGKVVECWDHKNGKKYVALKIIRNVEKYREAAWVEINQIMKKINEKHDPNNKYWEHCWKMNDWFDYGHGHICIVFELYGLSIYDFMKSN

H------FEGFNLSLVKCFARQVLVSLQFLHRARIIHGDLKPENILL
.      .... .. .. .|.| . ...|||  ...| |||||||..
NSKMPNKYIPYPIDHIRHMAYQLCEAVKFLHDMKLTHTDLKPENICF
Kinase DYRK2_a.AA DyrkP 116-318 38 9.8e-49 158.26 In-house 1-205 (323) Show / Hide 
Range on Protein: 116-318
Range on HMM: 1-205/323
Sequence Identity: 38% (81 aa)

YEILGKLGRGSFGQVLKCTDHKYKVPRAIKIIRNKKQFTQQAFIEINLLEFLR-NKAAEEGVDYNIVTIYESFEFRGHLCLSFAVHDISLFDMLKKN---
| |.  ||   | . ..| | .      .||| | | .  |.  || || ..  |   .|    |.. .|. |  . || .   . .  |..  | |   
YQIMEYLGSAAFSKAIQCQDKQTNQMMCMKIIENNKDYFDQSIDEIKLLRYINYNGDVDE---KNVLRYYDYFYHKEHLFIITELLKDNLYEFYKFNREN

-HFEGFNLSLVKCFARQVLVSLQFLHRARIIHGDLKPENILLQQPASPKIKLIDFGSSCFEHERIYTYIQSRFYRAPEVILGLPYDMMIDVWSFACILAE
     | .  ..    |.|..| ..|  |.|| ||||||||..  .  ..|.|||||||| |. .  |.||| |||||||.|  ||  ||.||  |||||
EQQRYFTVGRLQKITQQILIALDYIHSLRLIHCDLKPENILMKSYPKCQVKIIDFGSSCFIHDHLSSYVQSRSYRAPEVIIGCKYDYRIDMWSLGCILAE

LFTGYPLF
|.||  ||
LWTGNVLF
Kinase DYRK2_a.AA PRP4 116-353 35 1.8e-48 167.32 In-house 1-240 (320) Show / Hide 
Range on Protein: 116-353
Range on HMM: 1-240/320
Sequence Identity: 35% (85 aa)

YEILGKLGRGSFGQVLKCT-DHKYKVPRAIKIIRNKKQFTQQAFIEINLLEFLRNKAAEEGVDYNIVTIYESFEFRGHLCLSFAVHDISLFDMLKKN-HF
|.. |. | | |. | .|    . .   |||||||.    .    |.  |  | .. .     . .| ....|..| |.|| |     .| ..|||    
YRVYGYCGQGVFSNVCRCRDQTRGNEMVAIKIIRNNEIMHKTGLRELEILQKLNDAPTDKNDKFHCVRMFRHFNHRQHMCLVFECMSMNLREVLKKYGKD

EGFNLSLVKCFARQVLVSLQFLHRARIIHGDLKPENILLQQPASPKIKLIDFGS-SCFEHERIYTYIQSRFYRAPEVILGLPYDMMIDVWSFACILAELF
 |. |  |  .|.| .. |. | .  |.| |.|| |||    .   .|..|||| |  . . |  | .||||||||.|.| |||  ||.|| .| |.||.
VGLHLKAVRSYAQQLFLALKHLKKCNILHADIKPDNILVNE-SKNTLKMCDFGSASHIHENEITPYLVSRFYRAPEIIIGHPYDYQIDMWSVGCTLYELY

TGYPLFPGEDEVEQLAYMMEVLGTPPLSLISQAKRKKMFFD
||  .|||    . |  .|.. |  |  .|   . |  .||
TGKIMFPGKTNNHMLKLFMDYKGKMPNKMIRKGQFKDNHFD
Kinase DYRK2_a.AA STE 116-414 20 9e-46 158.39 In-house 1-359 (359) Show / Hide 
Range on Protein: 116-414
Range on HMM: 1-359/359
Sequence Identity: 20% (83 aa)

YEILGKLGRGSFGQVLKCTDHK---------------YKVPRAIKIIRNKK------------------QFTQQAFIEINLLEFLRNKAAEEGVDY-NIV
.|...|.|.|.||.| |. .||                ..  |||... ..                  .  ||   ||...  ...      .   |||
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNH------M-HPNIV

TIYESFEFRG-------HLCLSFAVHD-ISLFDMLKKNHFEGFN------------LSLVKCFARQVLVS-LQFLHRARIIHGDLKPENILLQQPASPKI
. | ...  |       .|..     |  || |..|...  |..             |......||.|   |..||. .||| |.|| ||||       .
KYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-------V

KLIDFGSSC-FEHE------------------RIYTYIQSRFYRAPEVILG------LPYDMMIDVWSFACILAELFTGYPLFPGEDEVEQLAYMM----
||.||| .  ....                  . .| . .  . |||||..       .||   |.||. | . |. || | .  .   . . ...    
KLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYH

---EVLGTPPLSLISQAKRKKMFFDSDNKPRIVPNSSGTRHFPSTKDLRMVVGC-----SD----------------------KSFVNFLSCCLKWDKEQ
   .                                           | ..|        |                      ..| .|.. ||. | ..
MQQQ----------------------------------------FEQL-CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNK

RMTPQQLLK--HEWI
| |..||||  |..|
RPTASQLLKSEHPFI
Kinase DYRK2_a.AA CLK 253-414 33 1e-41 122.39 In-house 179-350 (350) Show / Hide 
Range on Protein: 253-414
Range on HMM: 179-350/350
Sequence Identity: 33% (58 aa)

QQPASPKIKLIDFGSSC---FEHERIYTYIQSRFYRAPEVILGLPYDMMIDVWSFACILAELFTGYPLFPGEDEVEQLAYMMEVLGTPPLSLISQAKR--
... .. |..|||||     |.||  .| ...| ||||||||||..    ||||..||| || ||. ||.. |..| || | ...|.|  .  .|. |  
WHVKNTHICVIDFGSATKIRFDHEHHSTIVSTRHYRAPEVILGLGWSQPCDVWSIGCILFELYTGFTLFQTHDNREHLAMMERIMGMPIPQWMIQRTRRF

--KKMFFDSDNKPRIVPNSSGTRHFPSTKDLRMVVGCSD---KSFVNFLSCCLKWDKEQRMTPQQLLKHEWI
  |. .|  .     . ||.|   .   | |.    | |    ..   ....|  |  .|.| .. |.|.. 
KVKQKYFYHNRLDWDWHNSDGRYVMENCKPLKQYMDCKDPEHRQLFDLIRKMLEYDPSKRITCKDALQHPFF
Kinase DYRK2_a.AA TyrKc 116-414 19 7.7e-12 -31.23 SMART 1-280 (280) Show / Hide 
Range on Protein: 116-414
Range on HMM: 1-280/280
Sequence Identity: 19% (67 aa)

YEILGKLGRGSFGQVLKCTDHKYKVPRAIKIIRNKKQFTQQAFI-EINLLEFL--RNKAAEEGVDYNIVTIYESFEFR-------GHLCLS--FAVHDIS
 . . |||.| ||.| |.|     .. |.| ... .   ...|. |....  |  ...        ||| .|             . |..   .. |  .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHP--------NIVRLYGVCTQQGRNFMYIEPLMIVMEYMPH-GD

LFDMLKKNHFEGFNLSLVKCFARQVLVSLQFLHRARIIHGDLKPENILLQQPASPKIKLIDFGSSCFEHER-------IYTYI----QSR-----FYRAP
| | |.|.. . ....    |. |.    ..||. ..|| ||   |.|.  .    .|  ||| | . ..         |       ...        ||
LKDYLRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH--TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAP

EVILGLPYDMMIDVWSFACILAELFT-GYPLFPGE----DEVEQLAYMMEVLGTPPLSLI----SQAKRKKMFFDSDNKPRIVPNSSGTRHFPSTKDLRM
|.|    .    |||||   . |.|| | .  ||.     . ...    .  . .|        |                                   
ECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS----------------------------------F

VVGCSDKSFVNFLSCCLKWDKEQRMTPQQLLKHEWI
 |.|.|. .    ..| . | |.| | ...  || .
-VCCPDEMYQ-IMKQCWHEDPEDRPTFSEI--HECF
Kinase DYRK2_a.AA HIPK 385-414 33 0.000726 7.51 In-house 300-329 (329) Show / Hide 
Range on Protein: 385-414
Range on HMM: 300-329/329
Sequence Identity: 33% (10 aa)

KSFVNFLSCCLKWDKEQRMTPQQLLKHEWI
..||. |   . ||...|.|| . |.|...
REFVHVLKKMCTWDAHKRITPCEALNHPFV
Kinase DYRK2_a.AA DyrkP 371-414 31 0.001202 7.12 In-house 280-323 (323) Show / Hide 
Range on Protein: 371-414
Range on HMM: 280-323/323
Sequence Identity: 31% (14 aa)

PSTKDLRMVVGCSDKSFVNFLSCCLKWDKEQRMTPQQLLKHEWI
|    ||  .   |  |. |   ||. |   | | .  |.| |.
PKHSNLRARLRTDDHMFIDFVRQCLQIDFTRRPTAKEALQHPWF
Kinase DYRK2_a.AA PRP4 390-414 40 0.019783 4.81 In-house 296-320 (320) Show / Hide 
Range on Protein: 390-414
Range on HMM: 296-320/320
Sequence Identity: 40% (10 aa)

FLSCCLKWDKEQRMTPQQLLKHEWI
.|  ||  | . | |. . |||  |
LLDKCLMLDPKKRITCNEALKHPFI
Kinase DYRK2_a.AA DYRK1 395-414 40 0.035138 2.88 In-house 302-321 (321) Show / Hide 
Range on Protein: 395-414
Range on HMM: 302-321/321
Sequence Identity: 40% (8 aa)

LKWDKEQRMTPQQLLKHEWI
|..| .||.|| . |.|...
LQYDPKQRITPYYALQHSFF