Gene CDC2-S2_o (S.moellendorffii)

CDC2-S2_o

Species: S.moellendorffii
Alias: CDC2-S2_o
External Links:
Annotation:

Classification

Group: CMGC
Family: CDK
Subfamily: CDC2-smoe2

Sequence

Name Sequence Type Origin Length Description Download
CDC2-S2_o.AA Protein None 391 None Fasta, JSON
CDC2-S2_o.NA RNA None 1176 None Fasta, JSON
CDC2-S2_o.kin_dom Protein Kinase Domain None 293 None Fasta, JSON

Protein domain

Protein domains of CDC2-S2_o.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase CDC2-S2_o.AA CMGC 81-367 20 3.2e-77 253.1 In-house 7-513 (513) Show / Hide 
Range on Protein: 81-367
Range on HMM: 7-513/513
Sequence Identity: 20% (107 aa)

LGQGTDGVVRLARN--------------RVTGAMVAVKKLS---SKHDAA----------DMMWECATLRACQ-----------------HKNIIHLHSK
.|.|| |||  .|.              . |. .||.||..    ...|               |.  |.  .                 |.||..|.  
IGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNIVKLYDI

LVTEQ-----------------GLFMVFELMDMDLCSYIWDVREREGK------------------------IPEVAVRSIMKQILEALA--FVHSKG--
.....                  |..|||.||.||. || . . ..                          ..  ..| .|.|||..|.  . ||..  
FYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKYCHSHWGN

LIHRDVKSSNVLINHNKNL--------------NNSVVIKLIDFSRVCFASAG---------------------SCKNMGNV---YYRAPELLLGGEKYI
 |||| | .|.|||||. |              . . ..|..||   .. .                       .  .  .|   .|||||.||| ..| 
IIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLGWKHYT

-------YGREIDIWAAGCIFLELLTG--------FPFGDDDGNFPPNSE-----------LDVMNSIVKWIGPVD---------------ETTWKGVNK
       |. .||.|..|||| |..||         |.      ||..||           .| .. |.| .|. .               | .| ...|
NHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPL------FPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIK

LENYNT-------------YKSS----------FPRNPSNLLQSRLGD-------------------------------------SPAYDLLRKMLCLNP
| .||.             ....          ||. | . ...   .                                     . | ||| |||...|
LPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDP

RERITAKEALESDYF
 .||||..||. .||
DKRITAEQALQHPYF
Kinase CDC2-S2_o.AA S_TKc 75-367 26 2.9e-66 227.35 SMART 1-231 (231) Show / Hide 
Range on Protein: 75-367
Range on HMM: 1-231/231
Sequence Identity: 26% (82 aa)

STQSPLLGQGTDGVVRLARNRVTGAMVAVKKLSSKHDAADMMWECATLRACQHKNIIHLHSKLVTEQGLFMVFELMDM---DLCSYIWDVREREGK--IP
 .   ..|.|. |.|...|.. ||  ||.|...      ... | . |.  .|.||..|.   .. . |.||.|..|    || .|| . . . ..  .|
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFP

EVAVRSIMKQILEALAFVHSKGLIHRDVKSSNVLINHNKNLNNSVVIKLIDFSRVCFASAGSCKNMGNVYYRAPELLLGGEKYIYGR-EIDIWAAGCIFL
|  .|..|.||..||.. ||.| ||||.| .|.|...        .||..||   ..         |  .|.|||.|       ||. ..|.|. |||. 
E-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--------HIKICDFGLARQL----TTFCGTPWYMAPEVL------GYGKCKCDWWSCGCILY

ELLTGFP-FGDDDGNFPPNSELDVMNSIVKWIGPVDETTWKGVNKLENYNTYKSSFPRNPSNLLQSRLGDSPAYDLLRKMLCLNPRERITAKEALE----
|.|.| | |               |. . | ||                                    ...| |..||.|. .|..|.|| |||.    
EMLCGYPPFP-------------QMQMMFKKIG------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWD

---SDYF
     .|
IKCHPWF
Kinase CDC2-S2_o.AA Pkinase 75-367 23 1e-55 196.25 Pfam 1-293 (293) Show / Hide 
Range on Protein: 75-367
Range on HMM: 1-293/293
Sequence Identity: 23% (74 aa)

STQSPLLGQGTDGVVRLARNRVTGAMVAVKKLSSKHDAADMMW-------ECATLRACQHKNIIHLHSKLVTEQGLFMVFELMDM-----DLCSYIWDVR
 .    .|.|. |.|...... || .||||... . .. . ..       |.. .. ..|.||. |.    ... . ||.|....     ||..||    
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST--

EREGKI--PEVAVRSIMKQILEALAFVHSKGLIHRDVKSSNVLINHNKNLNNSVVIKLIDF--SRV--CFASAGSCKNMGNVYYRAPELLLGGEKYIYGR
.|.|..  .|  ....|.|||..|.. ||.| ||||.|..|.||..| ...    .|..||  ...     .       |  .|.|||...  .   ||.
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA--CVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR--GGQYYGP

EIDIWAAGCIFLELLTG-FPFGDDDGNFPPNSELDVMNSIVKWIGPVDETTWKGVNKLENYNTYKSSFPRNPSNLLQSRLGDSPAYDLLRKMLCLNPRER
..|.|..|||. |.|.| .|| ... . ...... ... | . . . |. .|  .   .  .. . .    . . .   . .... |.....||..| .|
KVDMWSCGCILYEMLCGRPPFPGHC-WHDNHDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H----F-HWTF-HNWSEECKDFIKWCLCKDPKKR

ITAKEALESDYF
.||...|....|
PTAEQILQHPWF
Kinase CDC2-S2_o.AA CAMK 80-367 19 5e-50 158.99 In-house 1-425 (425) Show / Hide 
Range on Protein: 80-367
Range on HMM: 1-425/425
Sequence Identity: 19% (87 aa)

LLGQGTDGVVRLARNRVTG------------AMVAVKKLS------------------------------SKHDAADMMWECATLRACQ-------HKNI
 ||.|. |.|.|.... |.              ||.| ..                              . .| . .. | . .. .|       |.||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IHLHSKLV------------TEQG--------LFMVF---ELM---DM--DLCSYI------------WDVREREGKIPEVAVRSIMKQILEALAFVHSK
|.|.                | .         ..||.   |..   ..  || .||             |.  ..|...|  .| ...||..|... ||.
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIV-ERGRFTEREARRYFRQICSAVHYCHSH

GLIHRDVKSSNVLINHNKNLNNSVV------------IKLIDFSRVCFASAG--------------------------SCKNMGNVYYRA-PELLLG---
. .||| |  |.|...|.. ... |            ||.|||   ..   |                               |  .| | ||.|.|   
NIVHRDLKPENILLDDNNDDSDP-VEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGH

--------GEKYIYGREIDIWAAGCIFLELLTG-FPFGDD---------DGNFPPNSELDVMNSIVKWIGPVDETTWKGVNKLE-N-YNTYKSSFPRNPS
        .||  ||...|.|..|.|   .|.| .|| .|                            ||  |. ... . | . . .  | |  ..| .
CNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEW------------------IGMNDYELFEKIMKGKYDFPPPYFSPISCN-Y

NLLQSRLGD-----------SPAYDLLRKMLCLNPRERITAKEALESDYF
   ..   |             . ||.||||. .| .|.|....|.   .
---GPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase CDC2-S2_o.AA Ciliate-E2 80-367 19 8.4e-42 141.26 In-house 6-365 (365) Show / Hide 
Range on Protein: 80-367
Range on HMM: 6-365/365
Sequence Identity: 19% (78 aa)

LLGQGTDGVVRLARNRVTGAM-----------------------VAVKKL-----SSKHDAADMM----------WECATLRACQHKNIIHLHSKLV--T
..|||. |.|...... .. .                       .|.| .      ..    ..|           |   |.  .|.||| ..      .
KIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEKD

EQGLFMVFELMDM-DLCSYIWDVREREGKIPE-------VAVRSIMKQILE---------------ALAFVHSKG-LIHRDVKSSNVLINHNKNLNNSVV
.. ...|.|. .  || .|| . .  .....|         .. ||||||.               || . |||.  |||| | .|.|.           
DNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----------

IKLIDFS------------RVCFASAGSCKNMG------------------------NVYYRAPELLLGGE------KYIYGREIDIWAAGCIFLELLTG
||.|||             .  .  .. ... .                        . .| ||| | |..      .  |. ..|||..|.|. |.|.|
IKIIDFGLSKKYDDDNQNRTH-KQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFG

-FPFGDDDGNFPPNSELDVMNSIVKWIGPVDETTWKGVNKLENYNTYKSSFPRNP--SNLLQ-------SRLGDSPA-YDLLRK----MLCLNPRERIT-
 .||                                    ...    | .|| .   .. .|       | .  |.   ||..|    ||. .| .||| 
KPPF------------------------------------QQQIKQCKIDFPCPEWQKD-TQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITG

AKEALESDYF
....|.  .|
WEQILNHPWF
Kinase CDC2-S2_o.AA CDK 240-367 38 5.9e-38 118.92 In-house 185-284 (284) Show / Hide 
Range on Protein: 240-367
Range on HMM: 185-284/284
Sequence Identity: 38% (50 aa)

YRAPELLLGGEKYIYGREIDIWAAGCIFLELLT---GFPFGDDDGNFPPNSELDVMNSIVKWIGPVDETTWKGVNKLENYNTYKSSFPRNPSNLLQSRLG
||||||||| ..|  | .||.|..|||| |..|   . |.      || .||.| .  | . .|  .| .| || || .|                    
YRAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPL------FPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY--------------------

DSPAYDLLRKMLCLNPRERITAKEALESDYF
     ||| ||||..|  ||.|..||...||
-----DLLNKMLCYDPKKRISAEQALQHPYF
Kinase CDC2-S2_o.AA CDK 81-221 30 7.6e-35 108.8 In-house 7-157 (284) Show / Hide 
Range on Protein: 81-221
Range on HMM: 7-157/284
Sequence Identity: 30% (50 aa)

LGQGTDGVVRLARNRVTG-----AMVAVKKLSSKH-------DAADM--MWECATLRACQHKNIIHLHSKLVTE-----------QGLFMVFELMDMDLC
.|.|| |||  ||.. ||      .|| ||.   .       .   .    |...|. . |.||. ||   .|.             |.|||| ||.|| 
IGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEYMDHDLK

SYIWDVREREGKIPEVAVRSIMKQILEALAFVHSKGLIHRDVKSSNVLINHNKNLNNSVVIKLIDF
.|.              ....|.|.|..|.. ||.. .||| | .| |||.| .     ..|. ||
KYMD-------------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVK-CGRLKIADF
Kinase CDC2-S2_o.AA CDC2 81-221 33 6.6e-33 98.07 In-house 7-147 (301) Show / Hide 
Range on Protein: 81-221
Range on HMM: 7-147/301
Sequence Identity: 33% (49 aa)

LGQGTDGVVRLARNRVTGAMVAVKKLSSKHDAAD------MMWECATLRACQ-HKNIIHLHSKLVTEQGLFMVFELMDMDLCSYIWDVREREGKIPEVAV
.| || |||  .... |. .||.||   ... ..       . |  .| . . |.||. ||  ..  . |.|||| .||||  |       . ..|. .|
IGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ-NKLYMVFEYLDMDLKKYMDMSIPKNKHMPPQLV

RSIMKQILEALAFVHSKGLIHRDVKSSNVLINHNKNLNNSVVIKLIDF
.|.|.|||....| |... .||| | .| ||. . |      ||. ||
KSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGN------IKIADF
Kinase CDC2-S2_o.AA CAMKL 74-221 30 1.6e-31 97.72 In-house 1-173 (297) Show / Hide 
Range on Protein: 74-221
Range on HMM: 1-173/297
Sequence Identity: 30% (54 aa)

YSTQSPLLGQGTDGVVRLARN-RVTGAMVAVKKLS-SKHDAADMMW----------------ECATLRACQ---HKNIIHLHSKLVTEQG------LFMV
|      ||.|. |.|.||.. | || .||.| .  .|    . |.                | . ..  .   |.|||.|.  . |..       ...|
YRIGK-TLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLV

FELMD---MDLCSYIWDVREREGKIPEVAVRSIMKQILEALAFVHSKGLIHRDVKSSNVLINHNKNLNNSVVIKLIDF
 |. .   |||  ||   ..| |..||   | . .||..|... ||.| .||| |  |.|. .|.|     .||.|||
MEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNN----NIKIIDF
Kinase CDC2-S2_o.AA CDC2 240-367 35 5.5e-31 92.05 In-house 171-301 (301) Show / Hide 
Range on Protein: 240-367
Range on HMM: 171-301/301
Sequence Identity: 35% (51 aa)

YRAPELLLGGEKYIYGREIDIWAAGCIFLEL---LTGFPFGDDDGNFPPNSELDVMNSIVKWIGPVDETTWKGVNKLENYNTYKSSFPRNPSNLLQSRLG
|||||.||| ..|  .  .|.|. |||| |.    |  |.      |.  || |    | . .|  .| || || .|     ||..||| . . |.. . 
YRAPEILLGCKRYSTP--VDMWSIGCIFAEMFMDVTKKPL------FHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPD---YKNTFPRWKPQDLSKICP

D---------SP--AYDLLRKMLCLNPRERITAKEALESDYF
.          .  . |||..||...|  ||.|||||.  ||
NNQKKKNQSCLDPEGIDLLMQMLQYDPQKRISAKEALQHPYF
Kinase CDC2-S2_o.AA CDK5 240-367 36 1.5e-29 90.12 In-house 164-287 (287) Show / Hide 
Range on Protein: 240-367
Range on HMM: 164-287/287
Sequence Identity: 36% (48 aa)

YRAPELLLGGEKYIYGREIDIWAAGCIFLELL-TGFPFGDDDGNFPPNSELDVMNSIVKWIGPVDETTWKGVNKLENYNTYKSSFPRNPSNL-LQSRLG-
||.|  |.|  .|     ||.| .|||| |.  .| |       || |.. | .  | | .|   | .| .. || .|.     .|  | .  .|.    
YRPPDVLMGSKHYS--TSIDMWSCGCIFAEMANAGRPL------FPGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPK

-DSPAYDLLRKMLCLNPRERITAKEALESDYF
 |.   ||| ||| .|| .||.||.||.  ||
LDEKGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase CDC2-S2_o.AA PITSLRE 240-367 38 4.7e-28 99.29 In-house 172-295 (295) Show / Hide 
Range on Protein: 240-367
Range on HMM: 172-295/295
Sequence Identity: 38% (51 aa)

YRAPELLLGGEKYIYGREIDIWAAGCIFLELLTGFPFGDDDGNFPPNSELDVMNSIVKWIGPVDETTWKGVNKLENYNTYKSSFPRNPSNLLQSRLG---
||||||||| .  .|   .|.|  |||| |..|. |       |. .||.| .| | |  |   |  | |...| . .  .. ||  | | | .| .   
YRAPELLLGCK--KYSTPVDMWSVGCIFAEFITMKPL------FQGKSEIDQINCIFKEMGTPTEKIWPGWTELPHWKMMNN-FPHYPYNNLRKRFPAEN

--DSPAYDLLRKMLCLNPRERITAKEALESDYF
     ..||| .||..|| .|||| .||  ..|
HISDTGFDLLNQMLTYNPKNRITASDALKHPWF
Kinase CDC2-S2_o.AA RCK 81-222 33 5e-25 76.11 In-house 7-159 (298) Show / Hide 
Range on Protein: 81-222
Range on HMM: 7-159/298
Sequence Identity: 33% (53 aa)

LGQGTDGVVRLARNRVTGAMVAVKKLSSKH----DAADMMWECATLRACQ-HKNIIHLHSKLVTEQ--GLFMVFELMDMDLCSYIWDVREREGKIPEVA-
|| || |.| .|.|  ||  || ||.  ..    . .    |   ||.   |.||| |.  .  .    |. |||.|||.|  .. |  ||. ..||   
LGDGTYGCVMKAQNKETGEIVAIKKMK-QKFYSWEECMNLREIKSLRKLNPHPNIIKLKEVIRDNDTYQLYFVFEYMDMNLYQMMKDFKERRKYLPENQR

-VRSIMKQILEALAFVHSKGLIHRDVKSSNVLINH-----NKNLNNSVVIKLIDFS
 ...||.||| .||. |..|  |||.|  | ...      ..   .. .||..||.
SIKNIMYQILQGLAHMHKHGFFHRDLKPENIMCTGSQQYFED--QDQDHIKIADFG
Kinase CDC2-S2_o.AA CDK5 76-210 33 1.2e-24 74.39 In-house 2-137 (287) Show / Hide 
Range on Protein: 76-210
Range on HMM: 2-137/287
Sequence Identity: 33% (47 aa)

TQSPLLGQGTDGVVRLARNRVTGAMVAVKKLSSKHD----AADMMWECATLRACQHKNIIHLHSKLVTEQGLFMVFELMDMDLCSYIWDVREREGKIPEV
 .   .| || |.|  |||. |. .|| |.     .     .  . | . |.  .||||. ||  . .|. | .||| .| ||  |. .. .   ..   
EKMEKIGEGTYGTVYKARNKETHEIVALKRVRLDSEDEGVPSTAIREICLLKELKHKNIVRLHDVIHSEKKLTLVFEFCDQDLKKYMDSCNG---EMDMH

AVRSIMKQILEALAFVHSKGLIHRDVKSSNVLINHNKNL
 ..|.| | |  ||| |..   ||| |  | ||| | .|
IIKSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGEL
Kinase CDC2-S2_o.AA MAPK 239-367 31 1.5e-24 81.64 In-house 196-328 (328) Show / Hide 
Range on Protein: 239-367
Range on HMM: 196-328/328
Sequence Identity: 31% (45 aa)

YYRAPELLLG---GEKYIYGREIDIWAAGCIFLELLT-GFPFGDDDGNFPPNSELDVMNSIVKWIGPVDETTWKGVNKLENYNTYKSSF---PRNPSNLL
.|||||..|.    .   |   .|.|..|||| |.|| . |.      || .. .| .| |.. .|  .|  .. . . |.. .| .|.   |. |   .
WYRAPEIMLNWIWMH---YTKAVDMWSVGCIFAEMLTDRKPL------FPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPW

QSRLGD------SPAYDLLRKMLCLNPRERITAKEALESDYF
.. . .      . | ||| ||| ..| .|||..|||.  ||
EKMFPNANFNANPQAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase CDC2-S2_o.AA MAPK 122-207 32 8.5e-15 47.38 In-house 58-153 (328) Show / Hide 
Range on Protein: 122-207
Range on HMM: 58-153/328
Sequence Identity: 32% (32 aa)

LRAC-QHKNIIHLHSKLVTE-----------QGLFMVFELMDMDLCSYIWDVREREGKIPEVAVRSIMKQILEA--LAFVHSKGLIHRDVKSSNVLINHN
|| . .|.||| |   .  |           . . .|.|||. ||.  |   .    .  .  ....| ||| .  | . || . |||| | ||.|.| |
LRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMETDLHQIIKSQQ----PLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNEN
Kinase CDC2-S2_o.AA TyrKc 80-367 18 1.5e-11 -35.89 SMART 6-280 (280) Show / Hide 
Range on Protein: 80-367
Range on HMM: 6-280/280
Sequence Identity: 18% (61 aa)

LLGQGTDGVVRLARNRVTGAMVAVKKLSSKHDAADMMWECATLRAC--QHKNIIHLHSKLVTE-------QGLFMVFELMDM-DLCSYIWDVREREGKIP
 || |  |.|.... .    .||||.| . .  .|.| |   ..    .|.||. |.   ...       . |..|.|.|.  || .|. . |..   ..
KLGEGAFGEVYKGTWK---IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK---LC

EVAVRSIMKQILEALAFVHSKGLIHRDVKSSNVLINHNKNLNNSVVIKLIDFSRVCFASAG----------------SCKNMGNVYYRAPELLLGGEKYI
     |.. || .  .. |||..||||    |.|...|.      ..|  ||    .   .                ..| |  .   ||| .    ...
MKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI---NYGK

YGREIDIWAAGCIFLELLT--GFPFGD---------------DDGNFPPNSELDVMNSIVKWIGPVDETTWKGVNKLENYNTYKSSFPRNPSNLLQSRLG
.  . |.|. |    |..|  . |  .               ..|. .|  . |    .                                     .   
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-P-MS------------------------------------FVCC

DSPAYDLLRKMLCLNPRERITAKEALESDYF
 .  |.. ..    .| .| | .|    ..|
PDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase CDC2-S2_o.AA RCK 239-290 44 9.3e-10 26.84 In-house 178-221 (298) Show / Hide 
Range on Protein: 239-290
Range on HMM: 178-221/298
Sequence Identity: 44% (23 aa)

YYRAPELLLGGEKYIYGREIDIWAAGCIFLELLTGFPFGDDDGNFPPNSELD
.|||||.||   .| .   .|||| |||. || . .|       || .||.|
WYRAPECLLRCTYYNS--PMDIWAVGCIMYELYMLRPL------FPGSSEID
Kinase CDC2-S2_o.AA RCK 342-367 50 1.3e-09 26.4 In-house 273-298 (298) Show / Hide 
Range on Protein: 342-367
Range on HMM: 273-298/298
Sequence Identity: 50% (13 aa)

DLLRKMLCLNPRERITAKEALESDYF
.|..|||. .| .||||..||.  ||
ELMEKMLQWDPQKRITAQQALQHPYF
Kinase CDC2-S2_o.AA PITSLRE 122-207 28 4.7e-09 29.3 In-house 55-142 (295) Show / Hide 
Range on Protein: 122-207
Range on HMM: 55-142/295
Sequence Identity: 28% (25 aa)

LRACQHKNIIHLHSKLV--TEQGLFMVFELMDMDLCSYIWDVREREGKIPEVAVRSIMKQILEALAFVHSKGLIHRDVKSSNVLINHN
|.| || ||. .   ..  .    .||.| .. || | .   ..|. .  .  . . | | | . .. |..  .||| | || |..|.
LMALQHPNIVNVKEIVMGSNMDKIYMVMEYVEHDLKSLMENMKRRNQPFKPGEIKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLYSHK
Kinase CDC2-S2_o.AA CAMKL 342-367 38 7.8e-08 20.93 In-house 272-297 (297) Show / Hide 
Range on Protein: 342-367
Range on HMM: 272-297/297
Sequence Identity: 38% (10 aa)

DLLRKMLCLNPRERITAKEALESDYF
||.||||  || .|.|... ..   .
DLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase CDC2-S2_o.AA Pkinase_Tyr 81-208 26 8.2e-08 27.09 Pfam 7-148 (270) Show / Hide 
Range on Protein: 81-208
Range on HMM: 7-148/270
Sequence Identity: 26% (38 aa)

LGQGTDGVVRLARNR----VTGAMVAVKKL--SSKHDA---ADMMWECATLRAC-QHKNIIHLHSKLV-TEQG--LFMVFELMDM-DLCSYIWDVREREG
||.|  |.|.... .     |.  ||||.|  .. |..   .|.| | ....   .|.||. |.   .  ..   ...|.|.|   || .|  . || ..
LGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQ

KIPEVAVRSIMKQILEALAFVHSKGLIHRDVKSSNVLINHNK
...     ..  || ..... .||..||||.   |.|...|.
PLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENN
Kinase CDC2-S2_o.AA CAMKL 240-264 42 8.7e-05 11.04 In-house 199-223 (297) Show / Hide 
Range on Protein: 240-264
Range on HMM: 199-223/297
Sequence Identity: 42% (11 aa)

YRAPELLLGG-EKYIYGREIDIWAAG
| |||...|. ..| .|...|||..|
YMAPEIFQGNNKPY-DGPKVDIWSCG
Kinase CDC2-S2_o.AA MAPK 74-107 37 0.222303 0.26 In-house 1-39 (328) Show / Hide 
Range on Protein: 74-107
Range on HMM: 1-39/328
Sequence Identity: 37% (15 aa)

YSTQSPLLGQGTDGVVRLARNRV------TGAMVAVKKLS
|  ..| .|||  |||  |. .       .|  ||.||.|
YQILKP-IGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKIS