Gene Chk1L_a (S.moellendorffii)

Chk1L_a

Species: S.moellendorffii
Alias: Chk1L_a
External Links:
Annotation:

Classification

Group: CAMK
Family: Chk1L

Sequence

Name Sequence Type Origin Length Description Download
Chk1L_a.AA Protein None 334 None Fasta, JSON
Chk1L_a.NA RNA None 1005 None Fasta, JSON
Chk1L_a.kin_dom Protein Kinase Domain None 260 None Fasta, JSON

Protein domain

Protein domains of Chk1L_a.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Chk1L_a.AA CAMK 11-265 26 7.1e-107 345.5 In-house 1-425 (425) Show / Hide 
Range on Protein: 11-265
Range on HMM: 1-425/425
Sequence Identity: 26% (112 aa)

DLGSGNFGVARLMRDKRTR------------ELVAVKFIER-----------------------------GERIDENVQREIINHRS-------LRHPNI
 ||.|.||. .| ..|.|             . ||.|.|..                              ..  .||.|||  ...       |.||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VQFKEASF----------------VMLT-PTHLAIIM---EYAAGGEL----FERICNA---------------GRFTEDEARYFFQQLISGVSYCHASE
... |.                  |. | ..|. ..|   ||. ||||    |..|.                 |||||.|||..|.|..|.| |||   
IKLYEVYEDPHYFKNTNDYETSKQVF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

ICHRDLKLENTLLDGSPAPR---------------LKICDFGYSKSALL------------------------HSQPKSTVGTPAYIA-PEVLSR-----
|.|||||.|| ||| .   .               .||.||| ..                                |  .|||.|.| ||||..     
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

--------KEYDGKLSDVWSCGVTLYVMLVGSYPFEDSADPR---------NFRKTIQRILNVQYT-IPDYVR---------------------VSQECR
        |.|.|. .|.||||| ||.||.| .||... | .         | ... ..|.. .|. .|.|.                      |||||.
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

HLLSRIFVATPAKRITISEIKKHPWF
.|.... .  | ||.||.....|||.
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase Chk1L_a.AA CAMKL 6-265 34 2.1e-106 340.58 In-house 1-297 (297) Show / Hide 
Range on Protein: 6-265
Range on HMM: 1-297/297
Sequence Identity: 34% (108 aa)

YELVRDLGSGNFGVARLMRD-KRTRELVAVKFIERGERI-----DEN-----------VQREIINHRSLR---HPNIVQFKEASFVMLTPTH------LA
|.... || |.||. .| .. . |.| ||.|.|..         . |           ..|||  ...|.   ||||... |   |. ||.|      . 
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYE---VIETPEHDIETKKIY

IIMEYAAGGE--LFERICNA----GRFTEDEARYFFQQLISGVSYCHASEICHRDLKLENTLLD--G-SPAPRLKICDFGYS-----K----SALLHSQP
..|||. |||  ||..|..     ||..|.||| .|.|..|.|.|||   |.|||.|.|| |||  | .    .||.||| |     .      .|. . 
LVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNN---NIKIIDFGFSNMYRPCIFGPGQKLKTF-

KSTVGTPAYIAPEVLSR--KEYDGKLSDVWSCGVTLYVMLVGSYPFEDSADP----RNFRKTIQRILNVQYTIPDYVRVSQECRHLLSRIFVATPAKRIT
    |.|.| |||....  |.|||.  |.|||||.||.|..| .||.|  ..     |. .   .|    | .| ...|| .||.|.... .  | ||.|
---CGSPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPT

ISEIKKHPWF
| .|..|||.
IHQIMNHPWM
Kinase Chk1L_a.AA S_TKc 6-265 34 3e-98 333.64 SMART 1-231 (231) Show / Hide 
Range on Protein: 6-265
Range on HMM: 1-231/231
Sequence Identity: 34% (94 aa)

YELVRDLGSGNFGVARLMRDKRTRELVAVKFIERGERIDENVQREIINHRSLRHPNIVQFKEASFVMLTPTHLAIIMEYAAG--GELFERICNAGR----
||..| .|.| ||. .. |.|.| ..||.| |       |...|||  ... .|||||.....       .|| ..|||. |  |.||..|.. ||    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD----DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--FTEDEARYFFQQLISGVSYCHASEICHRDLKLENTLLDGSPAPRLKICDFGYSKSALLHSQPKSTVGTPAYIAPEVLSRKEYDGKLSDVWSCGVTLYV
  |.| .||....|..... |||   |.||||| || |||     ..|||||| ..        .. .||| |.|||||    |... .|.||||..|| 
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE

MLVGSYPFEDSADPRNFRKTIQRILNVQYTIPDYVRVSQECRHLLSRIFVATPAKRITISEIKK-------HPWF
||.|  ||.      .  .....|.            |.|..........  |.||.|. |. .       ||||
MLCGYPPFP------QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase Chk1L_a.AA MARK 6-265 39 5.6e-96 314.19 In-house 1-262 (262) Show / Hide 
Range on Protein: 6-265
Range on HMM: 1-262/262
Sequence Identity: 39% (107 aa)

YELVRDLGSGNFGVARLMRDKRTRELVAVKFIERGERID----ENVQREIINHRSLRHPNIVQFKEASFVML--TPTH-LAIIMEYAAGGELFERICNA-
|.... .| |.... .| ..|.|.. ||.|..|.    |    .||.|||  ...| ||||... .   |.   |..| . .||||| ||||...| .. 
YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFH---VIEQDTEQHQIYLIMEYASGGELYDYIKAHP

-GRFTEDEARYFFQQLISGVSYCHASEICHRDLKLENTLLDGSPAPRLKICDFGYSKSALLHSQPKSTVGTPAYIAPEVLSRKEYDGKLSDVWSCGVTLY
 || .|.||| .|.|..|.|.|||   |.|||.|.|| |.|       ||.|||.|      .  ..  |||.| |||....|.|||.  |.||.|| ||
NGRLHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVLY

VMLVGSYPFEDSADPRNFRKTIQRILNVQYTIPDYVRVSQECRHLLSRIFVATPAKRITISEIKKHPWF
.|..|..||.  .|  .. .  ..||. .|.||..  || |||.|..|.... | .|.||.|| ||||.
FMVCGYFPFD--GDTQDYKELYKKILRGKYDIPCH--VSKECRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase Chk1L_a.AA AMPK 6-265 42 8.9e-93 275.77 In-house 1-254 (254) Show / Hide 
Range on Protein: 6-265
Range on HMM: 1-254/254
Sequence Identity: 42% (113 aa)

YELVRDLGSGNFGVARLMRDKRTRELVAVKFIER----GERIDENVQREIINHRSLRHPNIVQFKEASFVM-LTPTHLAIIMEYAAGGELFERICNAGRF
| .   .| | ||   .   ..|.| ||.| ...    ..  .| .|||| . ...|||.|.|  |   |   ||| . ..|||..|||||. |.  || 
YIIGKTIGEGTFGKVKMGTHILTGEKVAIKILNKQKIKDQDMVERIQREIHILKLFRHPHIIQLYE---VIIETPTDIFMVMEYVSGGELFDYIVKHGRL

TEDEARYFFQQLISGVSYCHASEICHRDLKLENTLLDGSPAPRLKICDFGYSKSALLHSQPKSTVGTPAYIAPEVLSRKEYDGKLSDVWSCGVTLYVMLV
.|.||. |||| ||||.|||   | |||||.|| |||     ..|| ||| |.      . |   | | | |||. | | | |   |.||||| ||.|| 
QEREACRFFQQIISGVEYCHRHMIVHRDLKPENLLLD--HNKNIKIVDFGLSNMMKDGEFLKTACGSPCYAAPEMISGKLYCGPEVDIWSCGVILYAMLC

GSYPFEDSADPRNFRKTIQRILNVQYTIPDYVRVSQECRHLLSRIFVATPAKRITISEIKKHPWF
|  ||.|.  |  ..|    |.| .|.||..  .|.|.. |....    | |||||..|..||||
GYLPFDDENTPTLYKK----IKNGEYYIPKF--LSPEAKDLIKHMLQVDPMKRITIHDIRNHPWF
Kinase Chk1L_a.AA Pkinase 6-265 31 4.2e-85 293.83 Pfam 1-293 (293) Show / Hide 
Range on Protein: 6-265
Range on HMM: 1-293/293
Sequence Identity: 31% (95 aa)

YELVRDLGSGNFGVARLMRDKRTRELVAVKFIERGERIDENVQR-----EIINHRSLRHPNIVQFKEASFVMLTPTHLAIIMEYAAGG----ELFERIC-
|...| .|||.||. .. ..| |...|||| |.. .. ..  |.     ||  ...|.|||||....   .. ...|. ..|||. ||    .||..|  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYD---WFEDKDHIYMVMEYCEGGLYVMDLFDYIST

-NAGRF--TEDEARYFFQQLISGVSYCHASEICHRDLKLENTLLD--GSPAPRLKICDFGYSKS--ALLHSQPKSTVGTPAYIAPEVLSRKEYDGKLSDV
 . |.|  .|.|.. .. |...|. |||.  |.|||||.|| |.|  | .....|||||| .|       | ... .||| |.||||.   .|.|. .|.
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

WSCGVTLYVMLVGSYPFEDS------ADPRNFRKTIQRILNVQYTIPDYVR---------------VSQECRHLLSRIFVATPAKRITISEIKKHPWF
||||..|| || |  || ..       .   .... ...|  ..  .. ..               .|.||........   |.||.|. .|..||||
WSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase Chk1L_a.AA Ciliate-E2 6-265 23 1.9e-75 256.99 In-house 1-365 (365) Show / Hide 
Range on Protein: 6-265
Range on HMM: 1-365/365
Sequence Identity: 23% (90 aa)

YELVRDLGSGNFGVARLMRDKRTRELVA------------------------VKFIERGERIDENVQREI--INH-----------RSLRHPNIVQFKEA
|.... .|.||||. ............|                          ..... .. .......  ||.           ..| ||||....|.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

SFVMLTPTHLAIIMEYAAGGELFERICNA-----------GRFTEDEARYFFQQLIS---------------GVSYCHASE-ICHRDLKLENTLLDGSPA
 | . . ... ..|||. ||.||..| |            ..||| |..|...|...               .. |.|    |.|||.|.|| |.     
-FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

PRLKICDFGYSKSALLHSQPKS--------------------------------TVGTPAYIAPEVLSRKEYDG--------KLSDVWSCGVTLYVMLVG
  .||.|||.|| .   .| ..                                ..||| | |||.|..|.||.        . .|.||.||.|| || |
--IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFG

SYPFEDSADPRNFRKTIQRILNVQYTIP----------------DYVRVSQECRHLLSR----IFVATPAKRIT-ISEIKKHPWF
 .||            .| |.. .. .|                ..  .|||| .|...    ...  | |||| ...|..||||
KPPF------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase Chk1L_a.AA QIK 6-265 36 1.4e-68 234.15 In-house 1-272 (272) Show / Hide 
Range on Protein: 6-265
Range on HMM: 1-272/272
Sequence Identity: 36% (104 aa)

YELVRDLGSGNFGVARLMRDKRTRELVAVKFIERGERIDEN----VQREIINHRSLRHPNIVQFKEASFVMLTPTHLAIIMEYAAGGELFERICNAGR--
|.. | .| |||.| .| | . | . ||.| | . ...||     . ||.    .|.||.|.   .   || |   . |..||. .||.|. .|. ||  
YDIERTIGKGNFAVVKLARHRITKTKVAIKIIDK-SQLDEENLQKCYREVQIMKMLYHPHIIKLYQ---VMETDDMMYIVTEYCSNGEMFDYLCKHGRKG

------------------FTEDEARYFFQQLISGVSYCHASEICHRDLKLENTLLDGSPAPRLKICDFGYSKSALLHSQPKSTVGTPAYIAPEVLSRKEY
                   .|.|||  |.|..|.| |||  .| ||||| || |||       || |||.|         .. .|.|.| |||..  |||
VKMVNSPDIGDQVLMGVPMAENEARRWFWQICSAVHYCHKRNIVHRDLKAENILLDNNMN--IKIADFGFSNWFKQGQLLMTWCGSPPYAAPEMFEGKEY

DGKLSDVWSCGVTLYVMLVGSYPFEDSADPRNFRKTIQRILNVQYTIPDYVRVSQECRHLLSRIFVATPAKRITISEIKKHPWF
||  .|.|| || |||.  |. ||  . .. | |   ||.|  .. || .  .||.| ||  .  |  |..|.||  |..|.| 
DGPKVDIWSMGVVLYVLVCGALPFDGKTLQ-NLR---QRVLSGKFRIPFF--MSQDCEHLIRHMLVVDPEHRYTIMQICQHRWM
Kinase Chk1L_a.AA Ciliate-E2-Unclassified 6-265 24 5.7e-67 228.81 In-house 1-352 (352) Show / Hide 
Range on Protein: 6-265
Range on HMM: 1-352/352
Sequence Identity: 24% (87 aa)

YELVRDLGSGNFGVARLMRDKRTRELV-----AVKFIERGERIDENVQREIINH-----------------------RSLRHPNIVQFKEASFVMLTPTH
|.... .|.|.||. .....| .  ..     . |....  .. .|.. ||.|                        ... ||.|| .    ..  .  .
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMF---YCFQDKQN

LAIIMEYAAGGELFERICN-----------------AGRFTEDEAR-----YFFQQLISGVSYCHASE-ICHRDLKLENTLLDGSP-APRLKICDFGYSK
. |.|||. ||.|.. |..                   .||| .|.     ..| |...| .|.| .  |.|||.|.|| |.| .    ..||.||| ||
IYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISK

SALLHSQ----------------PKSTVGTPAYI----APEVLSRKEYDG---KLSDVWSCGVTLYVMLVGSYPFE--DSADPRNFRK----------TI
     ..                 ....||| |.    ||||| ...||.   . .|.||.|| || || | |||.  .. . ..  .           .
KYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLY

QRILNVQYTIPDYV------RVSQECRHLLS----RIFVATPAKRITISEIKKHPWF
| |.. .. .| .       ..|.|. ....    ....  | ||||...|..||||
QNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase Chk1L_a.AA CAMK-Unique 6-265 23 3.5e-66 217.41 In-house 1-363 (363) Show / Hide 
Range on Protein: 6-265
Range on HMM: 1-363/363
Sequence Identity: 23% (84 aa)

YELVRDLGSGNFGVARLMRDKRTRELVAVKFIER-GERIDENVQ--------------------REIINHRSLRHPNIVQFKEA-SFVMLTPT-------
|...| .|.||||. .   |. |. . |.| ..  .  .. ..|                    ||.   ... ||||... .    . ....       
YKMHRIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLI

--------HLAIIMEYAAGGELFERICN--------------------AGRFTE--DEARYFFQQLISGVSYCHASEICHRDLKLENTLLDGS-P-----
        .. |.|||. ||.||. |                       |.|.|   ...  .|.| | |.| |   | |||||||| ..  | .     
IKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHH

--------APRLKICDFGYSKSAL-LHSQ--PKSTVGTPAYIAP--------------EVLSRKEYDGKLS---DVWSCGVTLYVMLVGSYPFEDSADPR
        . ..|.|||| ..     ..   .....||| |.||              ||. .  ||...|   | ||.||..| ||.|. ||. . ..|
RDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDCECEDR

----NFRKTIQRILNVQY---TIPDYVR---VSQECRHLLSRIFVATPAKRITISEIKKHPWF
       .....|.  .|     . . .   .|||   .. . ..  |..|....|...|.|.
DYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI
Kinase Chk1L_a.AA ULK 6-265 28 4.5e-64 219.17 In-house 1-324 (324) Show / Hide 
Range on Protein: 6-265
Range on HMM: 1-324/324
Sequence Identity: 28% (94 aa)

YELVRDLGSGNFG-VARLMRDKRT---RELVAVKFIERGERID-----------ENVQREIINHRSLR---HPN--IVQFKEASFVMLTPTH--LAIIME
|.| . ||.| || .    |.|.|    ..||.| |.. . ..           .. ..|| . . |    |||  ||.... .    |..|  . ||||
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFE---TSNHNNIYIIME

YAAGGELFERIC---------NAGRFTEDEARYFFQQLISGVSYCHASEICHRDLKLENTLLDGSPA----------PRLKICDFGYSKS----ALLHSQ
|  || |.. |          . .|..|.||. ||.|...|  . |   | |||.|..| |.    .          ..|||.||| .|.     .   .
YCNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQM

PKSTV------GTPAYIAPEVLS----RKEYDGKLSDVWSCGVTLYVMLVGSYPFEDSADPRNFRKTIQRILN-----------VQYTIP---DYVRVSQ
 ...|      ||| | ||..|.    .|.|. . .|.|| |. .| || |.|||. .     . . ||. .|            .  .|   . . .|.
CQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLY-IQKLINNGKEQQIYIKNQPIQFPKPPKDPKISP

ECRHLLSRIFVATPAKRITISEIKKHPWF
||. |..| ..  . .||.. || .||||
ECKDLIRRMLQYDEKDRISWEEIFNHPWF
Kinase Chk1L_a.AA ULK 6-265 28 1.1e-62 214.54 In-house 1-329 (329) Show / Hide 
Range on Protein: 6-265
Range on HMM: 1-329/329
Sequence Identity: 28% (95 aa)

YELVRDLGSGNFGVARLMRDKRTR----ELVAVKFIERGERIDEN-----------VQREIINHRSLR--------HPNIVQFKEASFVMLTPTH--LAI
|.| . ||.| ||.    |.|.|     |.||.| |.. . . .|           ...|| . . |         |||||.... .    |..|  . |
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFE---TSNHNNIYI

IMEYAAGGELFERIC----------NAGRFTEDEARYFFQQLISGVSYCHASEICHRDLKLENTLLDGSPA----------PRLKICDFGYSKSALLH--
||||  || |.. |           . .|..|.||. ||.|...|  . |   | |||.|..| |..   .          ..|||.||| .|.      
IMEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNM

SQP--KSTV------GTPAYIAPEVLS----RKEYDGKLSDVWSCGVTLYVMLVGSYPFEDSADPRNFRKTIQRILNVQYTIP--------------DYV
.|   ...|      ||| | ||..|.    .|.|. . .|.|| |. .| ||.| .||. .     . . ||. .| ....|              . .
EQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDP

RVSQECRHLLSRIFVATPAKRITISEIKKHPWF
 .|.||. |..| ..  . .||.. |. .||||
QISPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase Chk1L_a.AA TyrKc 6-265 23 3e-14 7.81 SMART 1-280 (280) Show / Hide 
Range on Protein: 6-265
Range on HMM: 1-280/280
Sequence Identity: 23% (70 aa)

YELVRDLGSGNFGVARLMRDKRTRELVAVKFIERGERIDENVQREIINHRSL--RHPNIVQFKEASFVM----LTPTHLAIIMEYAAGGELFERICNAGR
 .| . ||.|.||. .. . |   . |||| .  .    |   ||.   ..|  .|||||..  .        .    | |.|||...| | ... . ..
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

-FTEDEARYFFQQLISGVSYCHASEICHRDLKLENTLLDGSPAPRLKICDFGYSKSALLH--------SQPKST-VGTP-----AYIAPEVLSRKEYDGK
 .. ..  .|  |  .| .| |   . ||||   | |..     . ||.||| |.    .           |..  |.         |||..  ...  |
KLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH--TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTK

LSDVWSCGVTLYVMLVGSYPFEDSADP----RNFRKTIQRILNV-QYTIPDY------VRVSQECRHLLSRIFVATPAKRITISEIKKHPWF
 ||||| ||... ..  .|  .   ..     . .  |... .     .|..      |. ..|   . ..   . |..| | |||  |  |
-SDVWSFGVCMWEIF--TYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase Chk1L_a.AA Pkinase_Tyr 6-90 27 1.2e-05 19.78 Pfam 1-94 (270) Show / Hide 
Range on Protein: 6-90
Range on HMM: 1-94/270
Sequence Identity: 27% (26 aa)

YELVRDLGSGNFGV---ARLM-RDKRTRELVAVKFI--ERGERI--DENVQREIINHRSL-RHPNIVQFKEASFVMLTPTHLAIIMEYAAGGEL
 .. . ||.|.||.   ...   .. |.  |||| .     ..    |   ||.   ..| .|||||..  .      | .. |.|||...| |
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDL