Gene Chk1L_c-2 (S.moellendorffii)

Chk1L_c-2

Species: S.moellendorffii
Alias: Chk1L_c-2
External Links:
Annotation:

Classification

Group: CAMK
Family: Chk1L

Sequence

Name Sequence Type Origin Length Description Download
Chk1L_c-2.AA Protein None 333 None Fasta, JSON
Chk1L_c-2.NA RNA None 1002 None Fasta, JSON
Chk1L_c-2.kin_dom Protein Kinase Domain None 256 None Fasta, JSON

Protein domain

Protein domains of Chk1L_c-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Chk1L_c-2.AA CAMKL 4-259 35 5.2e-108 345.81 In-house 1-297 (297) Show / Hide 
Range on Protein: 4-259
Range on HMM: 1-297/297
Sequence Identity: 35% (109 aa)

FEFVQDIGSGNFGIARLMRE-KETGELVAVKFIERGEKI-----DEN-----------VQREIINHRSLR---HPNIIRFKEVMLTPTH------LAIAM
..... .| |.||  .| .  . ||| ||.|.|..  .      . |           ..|||  ...|.   |||||.. ||. ||.|      . . |
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

EYAAGGE--LFERICNA----GRFSEDEARFFFQQLISGVSYCHQNEICHRDLKLENTLLD--G-SPAPRLKICDFGYSKSAV-L----HSQPKSTVGTP
||. |||  ||..|..     ||..|.|||..|.|..|.|.|||.. |.|||.|.|| |||  | .    .||.||| |              |   |.|
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNN---NIKIIDFGFSNMYRPCIFGPGQKLKTFCGSP

AYIAPEVLSR--KEYD-GKANVWSCGVTLYVMLVGAYPFEDPEDP----RNFRKTIGRILSVQYSIPDYVRISSDCRHLLSRIFVANPSKRITIPEIMRH
.| |||....  |.||  |. .|||||.||.|..|..||.|. ..     |. .   .| .  | .| ....| |||.|.... . ||.||.|| .||.|
PYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNH

PWF
||.
PWM
Kinase Chk1L_c-2.AA CAMK 9-259 25 3e-104 336.88 In-house 1-425 (425) Show / Hide 
Range on Protein: 9-259
Range on HMM: 1-425/425
Sequence Identity: 25% (107 aa)

DIGSGNFGIARLMREKETG------------ELVAVKFIER-----------------------------GEKIDENVQREIINHRS-------LRHPNI
 .|.|.||. .| ..|.|.            . ||.|.|..                              .|  .||.|||  ...       |.||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IRFKEVML------------TPTH--------LAIAM---EYAAGGEL----FERICNA---------------GRFSEDEARFFFQQLISGVSYCHQNE
|.. ||.             | ..        . . |   ||. ||||    |..|.                 |||.|.|||..|.|..|.| |||.. 
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

ICHRDLKLENTLLDGSPAPR---------------LKICDFGYSKSAVL------------------------HSQPKSTVGTPAYIA-PEVLSRKE---
|.|||||.|| ||| .   .               .||.||| ..                                |  .|||.|.| ||||..|    
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

-----------YDGKANVWSCGVTLYVMLVGAYPFEDP---EDPR------NFRKTIGRILSVQYS-IPDYVRISS---------------------DCR
           |. |. .||||| ||.||.| .||...   |..       | ...  .|.. .|. .|.|. ..|                     .|.
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

HLLSRIFVANPSKRITIPEIMRHPWF
.|.... . .|.||.|| ....|||.
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase Chk1L_c-2.AA S_TKc 4-259 34 1.9e-100 340.9 SMART 1-231 (231) Show / Hide 
Range on Protein: 4-259
Range on HMM: 1-231/231
Sequence Identity: 34% (94 aa)

FEFVQDIGSGNFGIARLMREKETGELVAVKFIERGEKIDENVQREIINHRSLRHPNIIRFKEVMLTPTHLAIAMEYAAG--GELFERICNAGR------F
.|... ||.| ||  .. |.|.||..||.| |       |...|||  ... .||||.....|. . .|| . |||. |  |.||..|.. ||      |
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

SEDEARFFFQQLISGVSYCHQNEICHRDLKLENTLLDGSPAPRLKICDFGYSKSAVLHSQPKSTVGTPAYIAPEVLSRKEYDG-KANVWSCGVTLYVMLV
.| .|||...|..... |||.. |.||||| || |||     ..|||||| ..        .. .||| |.|||||    |.. |. .||||..|| ||.
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC

GAYPFEDPEDPRNFRKTIGRILSVQYSIPDYVRISSDCRHLLSRIFVANPSKRITIPEIMR-------HPWF
|  ||.      .  ... .|.            |............ .|.||.|. |...       ||||
GYPPFP------QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase Chk1L_c-2.AA MARK 4-259 39 2.2e-94 308.89 In-house 1-262 (262) Show / Hide 
Range on Protein: 4-259
Range on HMM: 1-262/262
Sequence Identity: 39% (106 aa)

FEFVQDIGSGNFGIARLMREKETGELVAVKFIERGEKID----ENVQREIINHRSLRHPNIIRFKEVML--TPTH-LAIAMEYAAGGELFERICNA--GR
..... || |...  .| . | ||. ||.|..|.  . |    .||.|||  ...| |||||.. .|.   |..| . . |||| ||||...| ..  ||
YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGR

FSEDEARFFFQQLISGVSYCHQNEICHRDLKLENTLLDGSPAPRLKICDFGYSKSAVLHSQPKSTVGTPAYIAPEVLSRKEYDGKAN-VWSCGVTLYVML
 .|.||| .|.|..|.|.|||.. |.|||.|.|| |.|       ||.|||.|      .  ..  |||.| |||....|.|||..  .||.|| ||.|.
LHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVLYFMV

VGAYPFEDPEDPRNFRKTIGRILSVQYSIPDYVRISSDCRHLLSRIFVANPSKRITIPEIMRHPWF
.| .||.  .|  .. .   .||. .|.||..  .| .||.|..|....||..|.|| |||.|||.
CGYFPFD--GDTQDYKELYKKILRGKYDIPCH--VSKECRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase Chk1L_c-2.AA AMPK 4-259 42 2.6e-92 274.38 In-house 1-254 (254) Show / Hide 
Range on Protein: 4-259
Range on HMM: 1-254/254
Sequence Identity: 42% (111 aa)

FEFVQDIGSGNFGIARLMREKETGELVAVKFIER----GEKIDENVQREIINHRSLRHPNIIRFKEVM-LTPTHLAIAMEYAAGGELFERICNAGRFSED
.   . || | ||   .   . ||| ||.| ...    ... .| .|||| . ...|||.||.  ||   ||| . . |||..|||||. |.  || .|.
YIIGKTIGEGTFGKVKMGTHILTGEKVAIKILNKQKIKDQDMVERIQREIHILKLFRHPHIIQLYEVIIETPTDIFMVMEYVSGGELFDYIVKHGRLQER

EARFFFQQLISGVSYCHQNEICHRDLKLENTLLDGSPAPRLKICDFGYSKSAVLHSQPKSTVGTPAYIAPEVLSRKEYDG-KANVWSCGVTLYVMLVGAY
||. |||| ||||.|||.. | |||||.|| |||     ..|| ||| |.      . |   | | | |||. | | | | .  .||||| ||.|| |  
EACRFFQQIISGVEYCHRHMIVHRDLKPENLLLD--HNKNIKIVDFGLSNMMKDGEFLKTACGSPCYAAPEMISGKLYCGPEVDIWSCGVILYAMLCGYL

PFEDPEDPRNFRKTIGRILSVQYSIPDYVRISSDCRHLLSRIFVANPSKRITIPEIMRHPWF
||.|.. |  ..|    |.. .|.||...  |.... |....   .| ||||| .|. ||||
PFDDENTPTLYKK----IKNGEYYIPKFL--SPEAKDLIKHMLQVDPMKRITIHDIRNHPWF
Kinase Chk1L_c-2.AA Pkinase 4-259 32 1.7e-89 308.44 Pfam 1-293 (293) Show / Hide 
Range on Protein: 4-259
Range on HMM: 1-293/293
Sequence Identity: 32% (96 aa)

FEFVQDIGSGNFGIARLMREKETGELVAVKFIERGEKIDENVQR-----EIINHRSLRHPNIIRFKEVMLTPTHLAIAMEYAAGG----ELFERIC--NA
..... ||||.||  .. ..| ||..|||| |.. .. ..  |.     ||  ...|.||||.|..... ...|. . |||. ||    .||..|   . 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GRF--SEDEARFFFQQLISGVSYCHQNEICHRDLKLENTLLD--GSPAPRLKICDFGYSKS--AVLHSQPKSTVGTPAYIAPEVLS-RKEYDGKANVWSC
|.|  ||.|..|.. |...|. |||.. |.|||||.|| |.|  | .....|||||| .|       | ... .||| |.||||.  ...|. |. .|||
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GVTLYVMLVGAYPFEDP------EDPRNFRKTIGRILSVQYSIPDYVR---------------ISSDCRHLLSRIFVANPSKRITIPEIMRHPWF
|..|| || |  || .       ..   .... |..|. ... .. ..               .|..|........  .|.||.|...|. ||||
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase Chk1L_c-2.AA AGC 4-259 22 9.9e-83 212.93 In-house 1-395 (395) Show / Hide 
Range on Protein: 4-259
Range on HMM: 1-395/395
Sequence Identity: 22% (90 aa)

FEFVQDIGSGNFGIARLMREK------ETGELVAVKFIERGE---KID----ENVQ--------------REIINHRSLR--------HPNIIR-FKEVM
|||.  || | ||  .| |.|       ||.. |.| ..  .   ...    |...              |.|  . . .        ||.|..  .   
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

LTPTH--LAIAMEYAA---------GG-ELFERIC---NAGRFSEDEARFFFQQ-------LISGVSYCHQ-NEICHRD-LKLENTLLDGSPAPRLKICD
 ...|  | . |||.          || ||| ...   . |||.|..|||.. .       ..... | |. . | ||| ||.|| |||      .|..|
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDED--GHIKLTD

FGYSKSAV---------------------------------------------------LHSQPKSTVG--TPAYIAPEVLSRKEYDGKANVWS--CGVT
|| .|  .                                                    . . .. .|  || |.|||.|    |.  .  ||   |. 
FGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCL

LYVMLVGAYPFEDPEDP------RNFRKTIGRILSVQYSIPDY--------------VRISSDCRHLLSRIFVANPSKRIT----------IPEIMRHPW
.| ||.|  || . ..       ||  ..  .|.. .| |..               . .|.....|... .. .|.||..          . ||..|||
MYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPW

F
|
F
Kinase Chk1L_c-2.AA Ciliate-E2 4-259 22 1.2e-72 247.7 In-house 1-365 (365) Show / Hide 
Range on Protein: 4-259
Range on HMM: 1-365/365
Sequence Identity: 22% (86 aa)

FEFVQDIGSGNFGIARLMREKETGELVA------------------------VKFIERGEKIDENVQREI--INH-----------RSLRHPNIIRFKEV
..|.. ||.||||. .... .......|                          ..... .. .......  ||.           ..| |||||...|.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

ML--TPTHLAIAMEYAAGGELFERICNA-----------GRFSEDEARFFFQQLIS---------------GVSYCHQNE-ICHRDLKLENTLLDGSPAP
    . ... . |||. ||.||..| |            ..|.| |......|...               .. |.|..  |.|||.|.|| |.      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------

RLKICDFGYSKSAVLHSQPKS--------------------------------TVGTPAYIAPEVLSRKE---------YDGKANVWSCGVTLYVMLVGA
 .||.|||.|| .   .| ..                                ..||| | |||.|..|.         || |. .||.||.|| || | 
-IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGK

YPFEDPEDPRNFRKTIGRILSVQYSIP----------------DYVRISSDCRHLLSR----IFVANPSKRIT-IPEIMRHPWF
.||            .  |.  ....|                ..  .| .| .|...    ... .|.|||| . .|. ||||
PPF------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase Chk1L_c-2.AA Ciliate-E2-Unclassified 4-259 23 6.2e-69 235.33 In-house 1-352 (352) Show / Hide 
Range on Protein: 4-259
Range on HMM: 1-352/352
Sequence Identity: 23% (84 aa)

FEFVQDIGSGNFGIARLMREKETGELV-----AVKFIERGEKIDENVQREIINH-----------------------RSLRHPNIIRFKEVMLTPTHLAI
..... ||.|.||. .....|... ..     . |....  |. .|.. ||.|                        ... ||.|... ..  .  .. |
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI

AMEYAAGGELFERICN-----------------AGRFSEDEAR-----FFFQQLISGVSYCHQNE-ICHRDLKLENTLLDGSP-APRLKICDFGYSKSAV
 |||. ||.|.. |..                   .|.| .|.     |.| |...| .|.|..  |.|||.|.|| |.| .    ..||.||| ||   
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ

LHSQ----------------PKSTVGTPAYI----APEVLSRKEYDGK----ANVWSCGVTLYVMLVGAYPFEDPEDPR----------------NFRKT
  ..                 ....||| |.    ||||| ...||..    . .||.|| || || | |||.|. .                   ... 
QNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNI

IGRILSVQYSIP--DYVRISSDCRHLLS----RIFVANPSKRITIPEIMRHPWF
. ...... . .  .  ..|  . ....    .... ||.||||...|. ||||
KQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase Chk1L_c-2.AA QIK 4-259 37 2.5e-67 230.01 In-house 1-272 (272) Show / Hide 
Range on Protein: 4-259
Range on HMM: 1-272/272
Sequence Identity: 37% (104 aa)

FEFVQDIGSGNFGIARLMREKETGELVAVKFIERGEKIDEN----VQREIINHRSLRHPNIIRFKEVMLTPTHLAIAMEYAAGGELFERICNAGR-----
..  . || |||.. .| | . | . ||.| | . ...||     . ||.    .|.||.||.  .|| |   . | .||. .||.|. .|. ||     
YDIERTIGKGNFAVVKLARHRITKTKVAIKIIDK-SQLDEENLQKCYREVQIMKMLYHPHIIKLYQVMETDDMMYIVTEYCSNGEMFDYLCKHGRKGVKM

---------------FSEDEARFFFQQLISGVSYCHQNEICHRDLKLENTLLDGSPAPRLKICDFGYSKSAVLHSQPKSTVGTPAYIAPEVLSRKEYDG-
                .|.|||. |.|..|.| |||. .| ||||| || |||       || |||.|         .. .|.|.| |||..  ||||| 
VNSPDIGDQVLMGVPMAENEARRWFWQICSAVHYCHKRNIVHRDLKAENILLDNNMN--IKIADFGFSNWFKQGQLLMTWCGSPPYAAPEMFEGKEYDGP

KANVWSCGVTLYVMLVGAYPFEDPEDPRNFRKTIGRILSVQYSIPDYVRISSDCRHLLSRIFVANPSKRITIPEIMRHPWF
|. .|| || |||.  || ||  . .. | |.   |.|| .. || .  .|.|| ||  .  | .|..|.||  |..|.| 
KVDIWSMGVVLYVLVCGALPFDGKTLQ-NLRQ---RVLSGKFRIPFF--MSQDCEHLIRHMLVVDPEHRYTIMQICQHRWM
Kinase Chk1L_c-2.AA ULK 4-259 27 6.3e-63 215.37 In-house 1-329 (329) Show / Hide 
Range on Protein: 4-259
Range on HMM: 1-329/329
Sequence Identity: 27% (91 aa)

FEFVQDIGSGNFGIARLMREKET----GELVAVKFIERGEKIDEN-----------VQREIINHRSLR--------HPNIIRFKEVMLTPTH--LAIAME
..  . .|.| ||     | |.|    .|.||.| |.. ... .|           ...|| . . |         ||||......  |..|  . | ||
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

YAAGGELFERIC----------NAGRFSEDEARFFFQQLISGVSYCHQNEICHRDLKLENTLLDGSPA----------PRLKICDFGYSKSAVLH--SQP
|  || |.. |           . .|.||.||. ||.|...|  . |.. | |||.|..| |..   .          ..|||.||| .|.      .| 
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

--KSTV------GTPAYIAPEVLS----RKEYD-GKANVWSCGVTLYVMLVGAYP----FEDPE-----DPRNFRKTIGR-ILSVQYSIPDY---VRISS
  ...|      ||| | ||..|.    .|.|.  |. .|| |. .| ||.| .|    |.|       . .| .....  | . .  .|..   . ||.
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAWFNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISP

DCRHLLSRIFVANPSKRITIPEIMRHPWF
.|. |..| .. ....||...|.  ||||
ECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase Chk1L_c-2.AA RSK 6-259 28 1.1e-62 214.51 In-house 1-278 (278) Show / Hide 
Range on Protein: 6-259
Range on HMM: 1-278/278
Sequence Identity: 28% (81 aa)

FVQD--IGSGNFGIARLMREKETGELVAVKFIERGEKIDENVQ-----REIINHRSLR-HPNIIRFKEVMLTPTHLAIAMEYAAGGELFERICNAGR---
  ..  .| | . . |  . . || . |.| ... . .  ..      .|.      . ||.|.. ...  |...| . |||  |||||..... ..   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FSEDEARFFFQQLISGVSYCHQNEICHRDLKLENTLLDG-SPA-PRLKICDFGYSKSAVLH--SQPKSTVGTPAYIAPEVLS----RKEYDGKANVWSCG
||||||.| . .... |.. ||  | |||||.|| |.|  |    ..|..||| .| ....  .. .. ..| .|.|||.|     .. .|  . .|| |
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDES-NEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLG

VTLYVMLVGAYPFEDPEDPRNFRKTIGRILSVQ--YSIPDYVRISSDCRHLLSRIFVANPSKRIT-----IPEIMRHPWF
| .| ||.|. ||  |.|  |  ... ||.. .   ..|    .| ....|... .  .|.||..     . || .||||
VLMYEMLTGCPPFQGPND-NNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase Chk1L_c-2.AA TyrKc 4-259 22 6e-14 2.84 SMART 1-280 (280) Show / Hide 
Range on Protein: 4-259
Range on HMM: 1-280/280
Sequence Identity: 22% (66 aa)

FEFVQDIGSGNFGIARLMREKETGELVAVKFIERGEKIDENVQREIINHRSL--RHPNIIRFKEVMLTP-------THLAIAMEYAAGGELFERICNAGR
 .. . .|.|.||. .. . |   . |||| .  .    |   ||.   ..|  .||||.|.  | ...         | | |||...| | ... . ..
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

-FSEDEARFFFQQLISGVSYCHQNEICHRDLKLENTLLDGSPAPRLKICDFGYSKSAVLH--------SQPKST-VGTP-----AYIAPEVLSRKEYDGK
 .. ..   |  |  .| .| |.. . ||||   | |..     . ||.||| |.    .           |..  |.         |||..  ...  |
KLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH--TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTK

ANVWSCGVTLY-VMLVGAYPFED-------PEDPRNFRKTIGRILSVQY-----SIPDYVRISSDCRHLLSRIFVANPSKRITIPEIMRHPWF
  ||| ||... ..  |. | ..       ... ... |. .|    ..     .    |. ...   . ..   ..|..| |  ||  |  |
SDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSF----VCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase Chk1L_c-2.AA Pkinase_Tyr 4-85 27 0.000129 16.26 Pfam 1-94 (270) Show / Hide 
Range on Protein: 4-85
Range on HMM: 1-94/270
Sequence Identity: 27% (26 aa)

FEFVQDIGSGNFGI---ARLM-REKETGELVAVKFI--ERGEKI--DENVQREIINHRSL-RHPNIIRFKEVML--TPT-HLAIAMEYAAGGEL
 .| . .|.|.||    ...   ...|.  |||| .     ..    |   ||.   ..| .||||.|.  | .      .. | |||...| |
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDL