Gene RSK-p4-2 (S.moellendorffii)

RSK-p4-2

Species: S.moellendorffii
Alias: RSK-p4-2
External Links:
Annotation:

Classification

Group: AGC
Family: RSK
Subfamily: RSK-p4

Sequence

Name Sequence Type Origin Length Description Download
RSK-p4-2.AA Protein None 457 None Fasta, JSON
RSK-p4-2.NA RNA None 1374 None Fasta, JSON
RSK-p4-2.kin_dom Protein Kinase Domain None 297 None Fasta, JSON

Protein domain

Protein domains of RSK-p4-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase RSK-p4-2.AA AGC 115-411 28 3.2e-140 365.03 In-house 1-395 (395) Show / Hide 
Range on Protein: 115-411
Range on HMM: 1-395/395
Sequence Identity: 28% (119 aa)

FKLMQRVGGGDIGIVFLAELVNS----SSSYRFAVKIMDKEH-LVKRN--KLSRIATE------------RRILEMLD----------HPFLPT-LYGSF
|..   .| |  | |.|.. ...    ..   .|.|...|.|  |...  .. .. ||            |.|||...          |||.   |. ||
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

ETSEH--ACFVMDFCP---------GG-DLHKLRQRQ-PKKRFDEETVRFYAAE-------VLLALEYLHM-MGVVYRD-LKPENVLVRDDGHIMLTDFD
.. .|   .|||...|         || .|.   | .  ..|||||..||||||       ..|||||||  ||...|| |||||.|  .||||.|||| 
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LSLE----------------------------FDAAPSMLKPHRLYGLRSPSINLKRSTSSLPQLNVEPAHLR--------------SMSFVG--THEYL
|. |                            .|  . .                        . . .  . .                .|.|  |.||.
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMD--T-N----------------------K-CNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYM

APEIIAGGGHGGAVDWWT--LGIFIYELLYGHTPFKGTNND----------ATLMNAF------SKSLLFPSD--------VEVSLFAKDLIKSLLVKDP
||||.    .| |.|||.  ||...||.|.|..|| | |..           .  .        .. . ||..        ...|  |||||| ||.|||
APEIL----YGKACDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDP

KRRLGFGR------GAADIKTHHFF
..||| |.      || .|| | .|
EKRLGCGGNDFGDKGAEEIKNHPWF
Kinase RSK-p4-2.AA RSK 118-411 33 6.4e-91 308.36 In-house 1-278 (278) Show / Hide 
Range on Protein: 118-411
Range on HMM: 1-278/278
Sequence Identity: 33% (105 aa)

MQRVGGGDIGIVFLAELV-NSSSSYRFAVKIMDKEHLVKRNK-LSRIATERRILEMLD-HPFLPTLYGSFETSEHACFVMDFCPGGDLHKLRQRQPKK-R
..  | |. | |||   . .. .   .|.|. .|  .|.|.| . .  |||.|||.   |||. ||. .|.| ..   .|..|.||.| .  |..  .  
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FDEETVRFYAAEVLLALEYLHMMGVVYRDLKPENVLVRD---DGHIMLTDFDLSLEFDAAPSMLKPHRLYGLRSPSINLKRSTSSLPQLNVEPAH--LRS
|.|....||.||. ||.|.||  |...|||||||.|  |   .|||.||||... .|                                   ...   . 
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQF-----------------------------------RCDHNQWT

MSFVGTHEYLAPEIIA----GGGHGGAVDWWTLGIFIYELLYGHTPFKG---TNNDATLMNAFSKS--LLFPSDVEVSLFAKDLIKSLLVKDPKRRLGFG
|.|..|.||.|||...    .|||. |.|||.||. .||.| |..||.|    | . .. .  ..   | .| . ..|  |||||. .| .||..||| |
MTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCG

-RGAADIKTHHFF
 ..|..|| | .|
PQDAEEIKQHPWF
Kinase RSK-p4-2.AA AktR 143-411 37 8.1e-89 301.37 In-house 28-268 (268) Show / Hide 
Range on Protein: 143-411
Range on HMM: 28-268/268
Sequence Identity: 37% (104 aa)

FAVKIMDKEHLVKRNKLSRIATERRILE-MLDHPFLPTLYGSFETSEHACFVMDFCPGGDLHKLRQRQPKKRFDEETVRFYAAEVLLALEYLHMM-GVVY
.| |. .|.....||. ... ||| |.| . .|||.  |. .|.| |.  |.|..||||.|    ..  ||.|.||..|||.|..||||||||    ..|
YAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKK--KKKFSEEQARFYFAQILLALEYLHQHMNIIY

RDLKPENVLVRDDGHIMLTDFDLSLEFDAAPSMLKPHRLYGLRSPSINLKRSTSSLPQLNVEPAHLRSMSFVGTHEYLAPEIIAG-GGHGGAVDWWTLGI
||||||| |   |||. .||| ||                                  ....    .  ||.||.||.|||.|    ||. .||||..||
RDLKPENILLDEDGHVKITDFGLSK--------------------------------LQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGI

FIYELLYGHTPFKGTNNDATLMNAFSKS-LLFPSDVEVSLFAKDLIK-SLLVKDPKRRLG-FGRGAADIKTHHFF
||||...|..||   |.   . .  .|  . ||  ...| ..||||.  || |.|. ||| .  |. .|| | .|
FIYEMVTGCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase RSK-p4-2.AA S_TKc 115-411 26 3.5e-88 300.19 SMART 1-231 (231) Show / Hide 
Range on Protein: 115-411
Range on HMM: 1-231/231
Sequence Identity: 26% (82 aa)

FKLMQRVGGGDIGIVFLAELVNSSSSYRFAVKIMDKEHLVKRNKLSRIATERRILEMLDHPFLPTLYGSFETSEHACFVMDFCPG--GDLHKLRQRQPKK
..... .| |  | |...  ..  .  ..|.||..           .|  |..||.. .||.. .||..|.. .| ..||..|.|  |||... ......
YEILRKIGKGAFGKVYKCRHKK--TGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH

R----FDEETVRFYAAEVLLALEYLHMMGVVYRDLKPENVLVRDDGHIMLTDFDLSLEFDAAPSMLKPHRLYGLRSPSINLKRSTSSLPQLNVEPAHLRS
.    |.| ..|||......||||.| .|...|||||||.|. .  ||...|| |. ..                                         
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----------------------------------------

MSFVGTHEYLAPEIIAGGGHGG-AVDWWTLGIFIYELLYGHTPFKGTNNDATLMNAFSKSLLFPSDVEVSLFAKDLIKSLLVKDPKRRLGFGRGAA---D
..|.|| .|.|||..   |.|. ..||| .|. .||.|.| .||    .......              |  |||.|. .|.|||..|..     .   |
TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWD

IKTHHFF
|| | .|
IKCHPWF
Kinase RSK-p4-2.AA Pkinase 115-411 27 7.6e-74 256.43 Pfam 1-293 (293) Show / Hide 
Range on Protein: 115-411
Range on HMM: 1-293/293
Sequence Identity: 27% (92 aa)

FKLMQRVGGGDIGIVFLAELVNSSSSYRFAVKIMDKEHLVKRNKLSRIA-TERRILEMLDHPFLPTLYGSFETSEHACFVMDFCPGG----DLHKLRQRQ
... ...| |  | |...  ....   ..||||..|.|  .  . ...  .| .|. .|.||.  .||..||.. | ..||..|.||    ||. . ...
YHIGRKIGSGSFGCVYKCHHKGTGK--IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTW

PKKRF--DEETVRFYAAEVLLALEYLHMMGVVYRDLKPENVLVRDDGHI----MLTDFDLSLEFDAAPSMLKPHRLYGLRSPSINLKRSTSSLPQLNVEP
 ...|  .|....||. ..| .|||.| ||...|||||||.|. ..|||     ..|| |.  ||                                 . 
RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD---------------------------------Y-

AHLRSMSFVGTHEYLAPEIIA-GGGHGGAVDWWTLGIFIYELLYGHTPFKGT------NNDATLMNAFSKSLLFPSDVEVS-------------------
     ..|.|| .|.|||.|  | ..| .||.| .|. .||.| |..||.|       . .. . .  .. | |... . |                   
NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWS

LFAKDLIKSLLVKDPKRRLGFGRGAADIKTHHFF
  .||.||..| ||||.|..    |..|. | .|
EECKDFIKWCLCKDPKKRPT----AEQILQHPWF
Kinase RSK-p4-2.AA Ciliate-E2 115-411 23 1.7e-67 230.56 In-house 1-365 (365) Show / Hide 
Range on Protein: 115-411
Range on HMM: 1-365/365
Sequence Identity: 23% (93 aa)

FKLMQRVGGGDIGIVFLAELVNSSSSY---------------------RFAVKIMDKEHLVKRNKLSRIA----------TERRILEMLDHPFLPTLYGS
.|. .  | |  |.|....  .    .                      .|.||| |  .   ..  .|            |..||| |.||..  .| .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FE--TSEHACFVMDFCPGGDLHKLRQRQPKKR---------FDEETVR---------------FYAAEVLLALEYLHMMG-VVYRDLKPENVLVRDDGHI
|.  . ..  .||..| |||| .. . ..|||         |.|. ..               ||.|...|||||||  . ...||.||||.|.     |
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

MLTDFDLSLEFD---------AAPSMLKPHRLYGLRSPSINLKRSTSSLPQLNVEPAHL-----RSMSFVGTHEYLAPEIIAGGG---------HGGAVD
 ..|| || ..|             ...  . .  |.|...                 .        ...|| .|.||||. |..         .. ..|
KIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMD----------------QIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCD

WWTLGIFIYELLYGHTPFKGTNNDATLMNAFSK-SLLFP----------------SDVEVSLFAKDLIKS----LLVKDPKRRLGFGRGAADIKTHHFF
.| ||. .||.|.| .||         ..   .  . ||                |  ..|. .|||||     .|.|||. |..   |. .|. |..|
IWSLGVILYEMLFGKPPF---------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRIT---GWEQILNHPWF
Kinase RSK-p4-2.AA RSK-Unclassified 115-266 42 4.1e-60 187.31 In-house 1-150 (283) Show / Hide 
Range on Protein: 115-266
Range on HMM: 1-150/283
Sequence Identity: 42% (64 aa)

FKLMQRVGGGDIGIVFLAELVNSSSSYRFAVKIMDKEHLVKRNKLSRIATERRILEMLDHPFLPTLYGSFETSEHACFVMDFCPGGDLHKLRQRQPKKRF
|     .| ||.| |.| .  ..   |  | |.. |. ....||  .. ||. |. . .|||  ||| || |.     .|..|.|||. .  |   .|.|
FIKHRLIGQGDFGKVYLVRKKDTQQIY--AMKVLHKHKMIRHNKIKYVMTEQNIMATTNHPFIVTLYHSFQTQDYLYLCMEYCMGGDFFRHLQTRKEKCF

DEETVRFYAAEVLLALEYLHMMGVVYRDLKPENVLVRDDGHIMLTDFDLSLE
 |. |||||.|| .||||||  ...||||||.|..   .||.|||||||| .
CEDDVRFYASEVTAALEYLHKRDFIYRDLKPDNIVLHQEGHVMLTDFDLSIQ
Kinase RSK-p4-2.AA RSK-Unclassified 307-411 50 5.5e-54 167.7 In-house 178-283 (283) Show / Hide 
Range on Protein: 307-411
Range on HMM: 178-283/283
Sequence Identity: 50% (54 aa)

RSMSFVGTHEYLAPEIIAGGGHGGAVDWWTLGIFIYELLYGHTPFKGTNNDATLMNAFSKSLLFPSDVEVSLFAKDLIKSLLVKDPKRRLGFGRG-AADI
|  ||.|| ||||||.| . ||. ||||||||| .||.| | .|..| | . |  |   . . || | ..|  ..|||| || . | .||| ..| |.||
RTNSFCGTEEYLAPEMIRRCGHTKAVDWWTLGIVMYEMLFGCPPYYGNNKNETFYNIEKNHVKFPHDSYISNNCRDLIKKLLQRNPAKRLGCKMGDADDI

KTHHFF
| | ||
KRHPFF
Kinase RSK-p4-2.AA Akt 143-261 47 7.4e-53 167.26 In-house 28-145 (264) Show / Hide 
Range on Protein: 143-261
Range on HMM: 28-145/264
Sequence Identity: 47% (57 aa)

FAVKIMDKEHLVKRNKLSRIATERRILEMLDHPFLPTLYGSFETSEHACFVMDFCPGGDLHKLRQRQPKKRFDEETVRFYAAEVLLALEYLHMMGVVYRD
.| |.  |......|..  . |||.||.. .|||.  |. || |... .||||.|.||.|  . ||  |.||.|.. |||.||. ||.|.|| ....|||
YAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQR--KRRFSEDRARFYCAEIILAIEHLHSKNIIYRD

-LKPENVLVRDDGHIMLTDF
 |||||.|.  |||| ||||
YLKPENILMDKDGHICLTDF
Kinase RSK-p4-2.AA SGK 115-264 35 1.3e-47 144.81 In-house 1-172 (283) Show / Hide 
Range on Protein: 115-264
Range on HMM: 1-172/283
Sequence Identity: 35% (61 aa)

FKLMQRVGGGDIGIVFLAELVNS----------------SSSYRFAVKIMDKEHLV-------KRNKLSRIATER-RILEMLDHPFLPTLYGSFETSEHA
|.... .| |  | |.... .                  |    .|.|.  |.| .       |...   | .||  ||  . |||.  |  .| | .  
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

CFVMDFCPGGDLHKLRQRQPKKRFDEETVRFYAAEVLLALEYLHMMGVVYRDLKPENVLVRDDGHIMLTDFDLS
 ||||.  ||..    ||   |.| |  .||||||. .||||||   ..||||||||.|  ..||. |||| |.
YFVMDYVNGGEMFYHLQRE--KHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLC
Kinase RSK-p4-2.AA PKA 115-261 36 1.4e-43 151.14 In-house 1-145 (263) Show / Hide 
Range on Protein: 115-261
Range on HMM: 1-145/263
Sequence Identity: 36% (54 aa)

FKLMQRVGGGDIGIVFLAELVNSSSSYRFAVKIMDKEHLVKRNKLSRIATERRILEMLDHPFLPT-LYGSFETSEHACFVMDFCPGGDLHKLRQRQPKKR
|...| .| |  | | |.   .|   | .| |...|.  |...   .. .|..||  ..|||. . .|..| .. .  .||...|||.. .  ..  ..|
FEIIQTLGTGSFGRVMLCRHKHSG-NY-YAMKMLKKQEIVRLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYLRK--SGR

FDEETVRFYAA-EVLLALEYLHMMGVVYRDLKPENVLVRDDGHIMLTDF
|.. . .|||| .. ||||||| .  .|||||||| |  ..||| .|||
FSNPHAKFYAASQIVLALEYLHSQNIIYRDLKPENILIDKNGHIKITDF
Kinase RSK-p4-2.AA MAST 115-264 38 2.1e-40 127.71 In-house 1-146 (334) Show / Hide 
Range on Protein: 115-264
Range on HMM: 1-146/334
Sequence Identity: 38% (58 aa)

FKLMQRVGGGDIGIVFLAELVNSSSSYRFAVKIMDKEHLVKRNKLSRIATERRILEMLDHPFLPTLYGSFETSEHACFVMDFCPGGDLHKLRQRQPKKRF
|.    .. |  | |.|..  . ..  |||.|...|  . ..| ..   .|| ||.|.. ||   .. ||.| .. |.||..  |||. .| .     .|
FEFIKPISKGAYGKVYLVK--HKKTNDRFAMKVIKKSDMINKNMVDQVQVERNILAMYQNPFVVKMFYSFQTKNYLCMVMEYMEGGDCASLLHMYG--YF

DEETVRFYAAEVLLALEYLHMMGVVYRDLKPENVLVRDDGHIMLTDFDLS
||.....| ||. |.||||| .| | |||||.|.|   .||| |||| ||
DEWMAKMYIAETVLCLEYLHSHGIVHRDLKPDNMLIDSNGHIKLTDFGLS
Kinase RSK-p4-2.AA MAST 115-264 36 5.1e-40 119.5 In-house 1-149 (337) Show / Hide 
Range on Protein: 115-264
Range on HMM: 1-149/337
Sequence Identity: 36% (55 aa)

FKLMQRVGGGDIGIVFLAELVNSSSSYRFAVKIMDKEHLVKRNKLSRIATERRILEMLDHPFLPTLYGSFET--SEHACFVMDFCPGGDLHKLRQRQPKK
|.    .. |  | |.|..  . ..  ||| |....  . ..| .  .  || ||.|.. ||   .. ||.|   .. |.||..  |||  .| .     
FEFIKCISKGAYGAVYLVK--HKKTNDRFAMKVINCQDTIDKNQVDQVFVERNILTMYQNPFVVKMFYSFQTPCKKYLCMVMEYMEGGDCASLLRMYGN-

RFDEETVRFYAAEVLLALEYLHMMGVVYRDLKPENVLVRDDGHIMLTDFDLS
...|. ...| ||  |.||||| .| | |||||.|.|   .||| |||| ||
CMPEWMAKMYIAETVLCLEYLHSYGIVHRDLKPDNMLIDSNGHIKLTDFGLS
Kinase RSK-p4-2.AA MAST 312-411 40 1.8e-39 117.82 In-house 229-337 (337) Show / Hide 
Range on Protein: 312-411
Range on HMM: 229-337/337
Sequence Identity: 40% (45 aa)

VGTHEYLAPEIIAGGG-HGGAVDWWTLGIFIYELLYGHTPFKGTNNDA-TLMNAFS--KSLLFPSD------VEVSLFAKDLIKSLLVKDPKRRLGFGRG
.|| .|.|||.| | | .| .|||| .|| .||.| | .|| | .    .  |  .  . . .|..       ..|  |.|||| || ..|| |||.. |
CGTPDYIAPEVILGQGTYGKPVDWWSMGIIMYEFLVGCPPFNGDTPEEMIFQNIINHDREIEWPEEGDPNDDDCMSPEAQDLIKKLLQPNPKKRLGAN-G

AADIKTHHFF
|..||.| ||
ADEIKQHPFF
Kinase RSK-p4-2.AA SGK 310-411 45 4.5e-38 114.84 In-house 184-283 (283) Show / Hide 
Range on Protein: 310-411
Range on HMM: 184-283/283
Sequence Identity: 45% (46 aa)

SFVGTHEYLAPEIIAGGGHGGAVDWWTLGIFIYELLYGHTPFKGTNNDATLMNAFSKSLLFPSDVEVSLFAKDLIKSLLVKDPKRRLGFGRGAADIKTHH
.| || ||||||.... .|. .|||| ||.. ||..||  ||   |      |  .. | .|    .|  |.|||. || |||| |||  |....|| | 
TFCGTPEYLAPEVLRKQPHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPP--QMSNDAWDLIQGLLQKDPKKRLGTKRDFMEIKNHP

FF
||
FF
Kinase RSK-p4-2.AA Akt 309-411 43 3.2e-36 113.23 In-house 160-264 (264) Show / Hide 
Range on Protein: 309-411
Range on HMM: 160-264/264
Sequence Identity: 43% (46 aa)

MSFVGTHEYLAPEIIAGGGHGGAVDWWT-LGIFIYELLYGHTPFKGTNNDATLMNAFSKSLLFPSDVEVSLFAKDLIKSLLVKDPKRRLG-FGRGAADIK
..| || |||||||. | ||. |||||. ||...||...|  ||   ...    . ... . ||    .|  .||||..|| ||||.||| .  .| .||
KTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGRPPFYNQDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIK

THHFF
 | .|
RHPWF
Kinase RSK-p4-2.AA MAST 312-411 39 4.6e-35 110.25 In-house 225-334 (334) Show / Hide 
Range on Protein: 312-411
Range on HMM: 225-334/334
Sequence Identity: 39% (43 aa)

VGTHEYLAPEIIAGGG-HGGAVDWWTLGIFIYELLYGHTPFKGTNNDATLMNAFSKS---LLFPSD------VEVSLFAKDLIKSLLVKDPKRRLGFGRG
.|| .|.|||.| | | || .|||| .|| .||.| | .|| . . . .  |  ...     .| .       . |  |.|||. ||  ||. |||.. |
CGTPDYIAPEVILGQGTHGKPVDWWSMGIIMYEFLVGCPPFNDDTPEEIFQNILNRNCNEIEWPEGGDINDDEAMSPEAQDLIEKLLQPDPRKRLGANNG

AADIKTHHFF
|...|.| ||
ADEVKQHPFF
Kinase RSK-p4-2.AA PKA 313-411 43 7.3e-35 122.15 In-house 160-263 (263) Show / Hide 
Range on Protein: 313-411
Range on HMM: 160-263/263
Sequence Identity: 43% (45 aa)

GTHEYLAPEIIAGG-GHGGAVDWWTLGIFIYELLYGHTPFKGT--NNDATLMNAFSKSLLFPSDVEVSL-FAKDLIKSLLVKDPKRRLGFGR-GAADIKT
|| |||||||| .  ||| .||||.||| |||.| |..||  .  .  ..     .  . ||. . . . . |||||.||..|...|.|  . |. |||.
GTPEYLAPEIIQSKNGHGKSVDWWALGILIYEMLAGYPPFYDHNRDPMQIYEKICNGKIKFPRHFDSDANYFKDLIKKLLQVDLTKRYGNMKNGVNDIKN

HHFF
| .|
HKWF
Kinase RSK-p4-2.AA TyrKc 115-405 19 1.2e-11 -34.23 SMART 1-280 (280) Show / Hide 
Range on Protein: 115-405
Range on HMM: 1-280/280
Sequence Identity: 19% (61 aa)

FKLMQRVGGGDIGIVFLAELVNSSSSYRFAVKIMDKEHLVKRNKLSRIATERRILEML--DHPFLPTLYGSFETS-------EHACFVMDFCPGGDLHKL
 .| .  | |  |.|.....      .  ||| . ...      .  .  | ||. .|  .|| .  |||   ..       |  . || ..|.|||.. 
ITLGKKLGEGAFGEVYKGTWK-----IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

RQRQPKKRFDEETVRFYAAEVLLALEYLHMMGVVYRDLKPENVLVRDDGHIMLTDFDLSLEFDAA-PSMLKPHRLYGLRSPSINLKRSTSSLPQ-LNVEP
 ..  .| .  ..   ..  .    |||| .... |||   |.|| .....  .|| || . .    .           | .   |.....    | .  
LRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG---------ESKDYYRKKEHKGGKTMLPI--

AHLRSMSFVGTHEYLAPEIIAGGGHGGAVDWWTLGIFIYELL-YGHTPFKG-----TNNDATLMNAFSKSLLFPSDV-------EVSLFAKDLIKSLLVK
              .||| |  |    . | |  |. ..|.. || .|  |      .|.  . .  .   . . .        . .    ...|.    
------------RWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHE

DPKRRLGFGRGAADI
||. |  |     ..
DPEDRPTFSEIHECF
Kinase RSK-p4-2.AA Pkinase_Tyr 115-243 23 3e-06 22.02 Pfam 1-137 (270) Show / Hide 
Range on Protein: 115-243
Range on HMM: 1-137/270
Sequence Identity: 23% (33 aa)

FKLMQRVGGGDIGIVFLAELV--NSSSSYRFAVKIMDKEHLVKRN-KLSRIATERRILEML-DHPFLPTLYGSFE-TSEH--ACFVMDFCPGGDLHK-LR
 ....  | |  | |.....    ..  .  |||.. ||.  ... ..     | .|.  | .|| .  |||     .|.   . || ..|.|||.. ||
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

QR-QPKKRFDEETVRFYAAEVLLALEYLHMMGVVYRDL
..  .|.... ..   .....  ..|||. .. . |||
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDL