Gene AqueK646 (A.queenslandica)

AqueK646

Species: A.queenslandica
Alias: AqueK646
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: HH498

Sequence

Name Sequence Type Origin Length Description Download
AqueK646.AA Protein None 1054 None Fasta, JSON
AqueK646.kin_dom Protein Kinase Domain None 253 None Fasta, JSON

Protein domain

Protein domains of AqueK646.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Ank AqueK646.AA Ank 53-85 30 0.41124 8.27 Pfam 1-33 (33) Show / Hide 
Range on Protein: 53-85
Range on HMM: 1-33/33
Sequence Identity: 30% (10 aa)

DGASLLHRFALLGLYDGVKALWERGAKPSILLS
|| . ||  .. | .. || | ..|| . .   
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank AqueK646.AA Ank 86-122 24 1.632909 6.11 Pfam 1-27 (33) Show / Hide 
Range on Protein: 86-122
Range on HMM: 1-27/33
Sequence Identity: 24% (9 aa)

DDSTLLHSAVRAGDPSQDQQRANILALFLNGSSRGVS
|  | || |.| |       ..... ..|.   .| .
DGFTPLHLACRCG-------HTEVVKMLLQ---HGAD
Ank AqueK646.AA Ank 131-163 48 4.2e-08 33.47 Pfam 1-33 (33) Show / Hide 
Range on Protein: 131-163
Range on HMM: 1-33/33
Sequence Identity: 48% (16 aa)

KGWTALKLAARKGLERSVETLLEHGADPNVPDN
 |.|.| ||.|.| .. |. ||.||||.|. |.
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank AqueK646.AA Ank 197-229 39 1e-06 28.03 Pfam 1-33 (33) Show / Hide 
Range on Protein: 197-229
Range on HMM: 1-33/33
Sequence Identity: 39% (13 aa)

KGETPLYLSVESGNVESAVTLLEHQADPNITNR
 |.||| | ...|..| .  ||.| ||.|....
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank AqueK646.AA Ank 230-262 39 1e-06 28.16 Pfam 1-33 (33) Show / Hide 
Range on Protein: 230-262
Range on HMM: 1-33/33
Sequence Identity: 39% (13 aa)

EGISPLFLAARGGNVDLVRVLLKNNAHVNVTGA
.| .|| ||.| |... |. ||...| ||..  
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank AqueK646.AA Ank 175-196 31 3.535213 4.9 Pfam 14-33 (33) Show / Hide 
Range on Protein: 175-196
Range on HMM: 14-33/33
Sequence Identity: 31% (7 aa)

HHAILKLLVSSRHPQNINAQTE
|. ..|.|..  |  ..|||. 
HTEVVKMLLQ--HGADVNAQDD
Ank AqueK646.AA Ank 264-296 36 4e-06 26.26 Pfam 1-33 (33) Show / Hide 
Range on Protein: 264-296
Range on HMM: 1-33/33
Sequence Identity: 36% (12 aa)

QNIAPLHWAAHKEFTEIALLLIEYGADVQLKDK
    |||.|...  ||.. .|...|||| ..|.
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank AqueK646.AA Ank 344-368 40 0.85692 7.12 Pfam 9-33 (33) Show / Hide 
Range on Protein: 344-368
Range on HMM: 9-33/33
Sequence Identity: 40% (10 aa)

ACGSGNVQALQALLQAGLNVNLTKD
|| .|... .. |||.| .||.. |
ACRCGHTEVVKMLLQHGADVNAQDD
Ank AqueK646.AA Ank 512-544 45 4.9e-09 36.86 Pfam 1-33 (33) Show / Hide 
Range on Protein: 512-544
Range on HMM: 1-33/33
Sequence Identity: 45% (15 aa)

DGWTPLMFAARSKSPAIVHYLLQRGVDPNHQQS
||.|||. |.|. .. .| .|||.| |.|.|  
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank AqueK646.AA Ank 545-577 30 4.9e-08 33.24 Pfam 1-33 (33) Show / Hide 
Range on Protein: 545-577
Range on HMM: 1-33/33
Sequence Identity: 30% (10 aa)

VGLTALHLAVQENQLDICQLLLKYKANPNIPGG
 | |.||||.. ........||.. |..|.   
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank AqueK646.AA Ank 403-444 33 2.2e-07 30.91 Pfam 1-33 (33) Show / Hide 
Range on Protein: 403-444
Range on HMM: 1-33/33
Sequence Identity: 33% (14 aa)

DGDTVLHYACMNKSPEGQGNHVSTLSYLLSTPCGTLINAQNS
||.| ||.||..        |.. ...||.  .|  .|||. 
DGFTPLHLACRCG-------HTEVVKMLLQ--HGADVNAQDD
Ank AqueK646.AA Ank 373-402 43 0.000111 21.14 Pfam 4-33 (33) Show / Hide 
Range on Protein: 373-402
Range on HMM: 4-33/33
Sequence Identity: 43% (13 aa)

TLLHLGAYCGQAGIVAMLLNNGANWQLVDK
| ||| ..||.. .| |||..||.  ..|.
TPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank AqueK646.AA Ank 445-477 33 0.001419 17.15 Pfam 1-33 (33) Show / Hide 
Range on Protein: 445-477
Range on HMM: 1-33/33
Sequence Identity: 33% (11 aa)

RGDTPLLVTIRCCYFDRARILLKHNADTTIRNA
 |.||| . .|| . . .. ||.|.||  ... 
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank AqueK646.AA Ank 478-511 26 3.720431 4.82 Pfam 1-33 (33) Show / Hide 
Range on Protein: 478-511
Range on HMM: 1-33/33
Sequence Identity: 26% (9 aa)

KNELPLHRACCGDCNIGIVLQLAEVFTDLDLRDK
  . ||| ||. . .. .|  | .   |....|.
DGFTPLHLACRCG-HTEVVKMLLQHGADVNAQDD
Ank AqueK646.AA Ank 579-611 33 2e-06 27.17 Pfam 1-33 (33) Show / Hide 
Range on Protein: 579-611
Range on HMM: 1-33/33
Sequence Identity: 33% (11 aa)

QLLTPLHIAAHKSFKDICLLLSDNGADISIQDK
   ||||.|...  .... .| ..|||. .||.
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank AqueK646.AA Ank 612-617 83 75.502822 0.1 Pfam 1-6 (33) Show / Hide 
Range on Protein: 612-617
Range on HMM: 1-6/33
Sequence Identity: 83% (5 aa)

DGDTPL
||.|||
DGFTPL
Kinase AqueK646.AA TKL 777-1030 25 1.6e-58 200.78 In-house 6-364 (364) Show / Hide 
Range on Protein: 777-1030
Range on HMM: 6-364/364
Sequence Identity: 25% (93 aa)

FFDVYLGTFRS----------IDVVVKKINRPPDVWECC-----------------------TRKTFQKEVEQLSRLQCPYVVQFMGAIMVPS-------
|  || |..|            ||.|||...  |  .                          |... .|. ..|||..| .|||||. . |.       
FGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMH

----SGLYCLVMEYMPNNDLHTLMHVKKTQLSKLEK-TQIIRDIAAGMAYLHS--F------PIIHRNLIPSNVLIGEKMN--------------AKVSD
    .| .|.||||.|. .|. ..|        ...  ....||| ||.||||  .      |||||.| ..|.|. |...              .|..|
PVGPWGQLCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICD

FGLYNTKVQTNFYADLRKLCL----------KDGNKR--PYYRAPEIIEKN----------------DFSTASDVYSFGIMLHELATQKRPFSDVDPCSN
|||  .. |..   |  . .           . ....  |.. |||.....                ..|...|||||||.| |..| .||..| .. . 
FGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPM

A------MVWVMKLLMGARPVIP------------SYLEPSCKQMMARLWHADPSMRPTFKEFLVKC
       . ..|  . | || ||            ..  || |. | . |..||. ||.|.| | . 
IFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase AqueK646.AA TKL-Unique 780-1030 28 1.7e-51 177.37 In-house 13-290 (290) Show / Hide 
Range on Protein: 780-1030
Range on HMM: 13-290/290
Sequence Identity: 28% (82 aa)

VYLGTFRSIDVVVKKINRPPDVWECCTRKTFQKEVEQLSRLQ-CPYVVQFMGAIM--VPSSGLYCLVMEYMPNNDLHTLMH---------VKKTQLSKLE
|| |..|...| .|...      .   ...| .||  ...|.  | .|..||. |   .. . .|.||||.| . |. . |          ... |. . 
VYKGKWRGYPVAIKQFHP-NEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQ

KTQIIRDIAAGMAYLHSFP--IIHRNLIPSNVLIGEK-----MNAKVSDFGLYNTKV--QTNFYADL---RKLCLKDGNK-RPYYRAPEIIEK--NDFST
. ....||| || |||.    ||||.| .||.|. ..     .|.|..||||  ..    ....  .   |    .....  . ..|||...   ...|.
RVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTR----NQTRCGSFRWMAPEVLRMNFCQYSE

ASDVYSFGIMLHELATQKR------PFSDVDPCSNA-MVWVMKLLMGARPVIPSYLEPSCKQMMARLWHADPSMRPTFKEFLVKC
 ||||||||.| |.|| |.      |....|. . . || .|  . . || ||. .... .  . . || ||| ||.| | . . 
KSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYM--EENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase AqueK646.AA TK 777-1030 14 6.8e-42 137.73 In-house 15-486 (486) Show / Hide 
Range on Protein: 777-1030
Range on HMM: 15-486/486
Sequence Identity: 14% (73 aa)

FFDVYLGTFRS---------------------------IDVVVKKINR--PPDVWE----CCTRKT--------FQKEVEQLS--RLQCPYVVQFMGAIM
| .||.|. |.                           ..| || .    . .  |    ....          .  | ....   ...| .|.. |...
FGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHD-RDGGEDFLEEAEEMKMMCHSLGHHPNIVRLYGVCT

VPSS----------GLYCLVMEYMPNND----LHTLMHVKKT----------------------------------------------------------
 . .          . ...||||||. |    |..  . ..                                                           
QGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKDHPPPLT

-----------------QLSKLEKTQIIRDIAAGMAYLHSFPI------IHRNLIPSNVLIGEKMN-----------AKVSDFG------LYNTKVQTNF
                 ||.  ..  . ..||.||.|||| ..      .||.|   |.|.||...           .|..|||      .         
TKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSG---------

YADLRKLCLKDGNKRPYYR-----------------------------------APEIIE---------KNDFSTASDVYSFGIMLHELAT--QKRPFSD
      |. .....  |||                                   ||| ..         .. |.|.|||.|||....|. |  |. .  .
-----VLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGG

VDP--------CSNAMVWVMKLLM---------GARPVIP--SYLE--------------PSCKQMMARLWHADPSMRPTFKEFLVKC
..         .   |  . . ..         | |   |   .                .   ..| . ||.||. ||||.. . . 
MSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase AqueK646.AA RIPK 789-1030 27 7.4e-36 119.65 In-house 19-290 (290) Show / Hide 
Range on Protein: 789-1030
Range on HMM: 19-290/290
Sequence Identity: 27% (76 aa)

DVVVKKINRPPDVWEC---CTRKTFQKEVEQLSRLQCPYVVQFMGAIMVP----SSGLYCLVMEYMPNNDLHTLMHVKKT-----QLSKLEKTQIIRDIA
|.|.||.   . . .      |.    |.. . .|.| ..|.  | .  .     ..|| .|||||.|  |  . | |        . .| .  .|  |.
DWVAKKCKPCKHCHTHMDDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPYQHHPDPWPL-RCRMIHEIS

AGMAYLHSFP--IIHRNLIPSNVLIGEKMNAKVSDFGLYNTKVQTNFYADLR--KLCLKDGNKRP----YYRAPEIIE---KND---FSTASDVYSFGIM
 || ||||    |||| | |.|.|.   ...|..||||   . .     | .  .  .  . | .    .| .|| ..   |.    .....|||||.| 
CGMCYLHSMNPPIIHRDLKPENILVDNNFHVKIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFRTDNKKPIKVVTPKYDVYSFAIV

LHELATQKRPFSDVDPCSNAMVWVMKLLMGARPVIPSYLEPSC--------KQMMARLWHADPSMRPTFKEFLVKC
. |. ||| |..|.    . |. .|..  | || ..   |..         .. | | |..||  ||.| |   . 
MWEVLTQKHPYEDR---KCMMMIMMCCKQGHRPCLQPVPEYWPEPPHCEQMIELMQRCWQQDPNDRPCFQECEEWT
S_TKc AqueK646.AA S_TKc 771-1034 21 6.8e-35 123.16 SMART 1-231 (231) Show / Hide 
Range on Protein: 771-1034
Range on HMM: 1-231/231
Sequence Identity: 21% (61 aa)

WESFQK-----FFDVYLGTFRS--IDVVVKKINRPPDVWECCTRKTFQKEVEQLSRLQCPYVVQFMGAIMVPSSGLYCLVMEYMPN--NDLHTLMHVKKT
.|  .|     |  ||... ..    | .|.|.           .....|.. |.. ..|..|.. ...     . ...||||...   ||..... ...
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGR

Q-----LSKLEKTQIIRDIAAGMAYLHSFPIIHRNLIPSNVLIGEKMNAKVSDFGLYNTKVQTNFYADLRKLCLKDGNKR---PYYRAPEIIEKNDFST-
.     ..  .   ... |. ...|.||  |||| | |.|.|. |  . |..||||                     .     |.|.|||..    ... 
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----------------TTFCGTPWYMAPEVL---GYGKC

ASDVYSFGIMLHELATQKRPFSDVDPCSNAMVWVMKLLMGARPVIPSYLEPSCKQMMARLWHADPSMRPTFKEFLV-----KCEEKL
..|..|.|..| |... . ||.        |  ..|...           |..|... .... ||. |||  | |      || . .
KCDWWSCGCILYEMLCGYPPFP-------QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
TyrKc AqueK646.AA TyrKc 772-1034 26 1e-31 112.64 SMART 1-280 (280) Show / Hide 
Range on Protein: 772-1034
Range on HMM: 1-280/280
Sequence Identity: 26% (81 aa)

ESFQKFF------DVYLGTFRSIDVVVKKINRPPDVWECCTRKTFQKEVEQLSRL--QCPYVVQFMGAIMVP-----SSGLYCLVMEYMPNNDLHTLMHV
 .. |         ||.|| . |.| ||...          |. | .| . ...|  . | .|.. |... .     ... ...||||||. ||.   . 
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

KKTQLSKLEKTQIIRDIAAGMAYLHSFPIIHRNLIPSNVLIGEKMNAKVSDFGLYNTKVQT-------NFYAD----LRK--LCLKDGNKRPYYRAPEII
.. .|.  .. ..  .||.||.|||| ..||| |   |.|.||.  .|.|||||                |       .|  | ..         ||| |
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIR-------WMAPECI

EKNDFSTASDVYSFGIMLHELATQ-KRPFSDV----DPCSNAMVWVMKLLMGARPVIPSY--------LEPSCKQMMARLWHADPSMRPTFKEFLVKCEE
 .. |.|.|||.|||... |. |  . | ...     . . .. .|..   | |. .| .          .   |.| . ||.||..||||.|      |
NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQ---GYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI----HE

KL
..
CF
Kinase AqueK646.AA Ciliate-E2 812-1027 18 1e-30 102.68 In-house 71-360 (365) Show / Hide 
Range on Protein: 812-1027
Range on HMM: 71-360/365
Sequence Identity: 18% (56 aa)

KEVE----------QLSRLQCPYVVQFMGAIMVPSSGLYCLVMEYMPNNDLHTLMHVKKTQ----------LSKLEKTQIIRDIAA--------------
.|..           |..|..|.....  .    .   . |||||   .||  ..  .|..          ..  |  .|.. |.               
REINCFYKKINEKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACII

-GMAYLHSFP-IIHRNLIPSNVLIGEKMNAKVSDFGL--YNTKVQTNFY-ADLRKLCLKDGNK----------------------RPYYRAPEIIE----
 .. ||||   ||||.. |.|.|.      |..||||  .... . | .   ..|...  .|.                       |.| ||||..    
LALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKY

-----KNDFSTASDVYSFGIMLHELATQKRPFSDVDPCSNAMVWVMKLLMGARPVIP------------------SYLEPSCKQMMAR----LWHADPSM
     ... ....|..|.|..|.|. . |.||             ..  .     .|                   .....||... .    .   ||. 
DNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF-------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEK

RPT-FKEFL
|.| ... |
RITGWEQIL
Kinase AqueK646.AA STE 807-1027 21 1.3e-29 101.79 In-house 72-352 (359) Show / Hide 
Range on Protein: 807-1027
Range on HMM: 72-352/359
Sequence Identity: 21% (62 aa)

RKTFQKEVEQLSRLQ--CPYVVQFMGAIMV----PSS-GLYCLVMEYMPNNDLHTLMH---VKKTQLSKL--------EKTQ--IIRDIAAG-MAYLHSF
.. ..||.. .....  .|..|.. |. ..     .. .  ...||||..  |  ...    .. .|..         |.    |.|.|  | ..|||| 
MQQILKEIKIMKKCNHMHPNIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSH

PIIHRNLIPSNVLIGEKMNAKVSDFGLYNTKVQTNFYADLRKLCLKDGN----------KR------PYYRAPEIIEK------NDFSTASDVYSFGIML
 |||| . |.|.|.     .| .|||.    ....    . .     .|          ||      | . |||.|..      .. .| .|..|.|...
HIIHRDIKPANILL-----VKLCDFGVCGQLTDSMANI-Q-S-----NNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTI

HELATQKRPFSDVDPCSNAMVWVMKLLMGA-----------RPVIPSYLE-------------------PSCKQMMARLWHADPSMRPTFKEFL
 |.|| | |..|  | .. . . ..  |..            | .|. |.                   |..|. ...    ||. ||| .. |
IEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLL
Kinase AqueK646.AA Pkinase_Tyr 779-912 30 6.3e-28 95.21 Pfam 14-157 (270) Show / Hide 
Range on Protein: 779-912
Range on HMM: 14-157/270
Sequence Identity: 30% (45 aa)

DVYLGTFR------SIDVVVKKINRPPDVWECCTRKT-----FQKEVEQLSRL-QCPYVVQFMGAIMVPSSG-LYCLVMEYMPNNDLHTLMHVK---KTQ
.||.|| .       |.| ||...      | .. .      | .|.. .. | ..| .|...|...  .    ...||||||. ||..  . .   | .
EVYKGTWKGDPDNTKIPVAVKMLK------EGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQP

LSKLEKTQIIRDIAAGMAYLHSFPIIHRNLIPSNVLIGEKMNAKVSDFGL
|.  .. |. ..||.||.||.| ..||| |   |.|..|.. .|..||||
LTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGL
Kinase AqueK646.AA Dicty4 780-912 34 2.8e-27 88.18 In-house 15-160 (277) Show / Hide 
Range on Protein: 780-912
Range on HMM: 15-160/277
Sequence Identity: 34% (50 aa)

VYLGTFRSIDVVVKKINRPPDVWECCTRKTFQKEVEQLSRLQCPYVVQFMGAIMVP--SSGLYCLVMEYMPNNDLHTLMHV------KKTQLS--KLEK-
||.|| | ..| ||| |   .. .  . . | |||. .. .. | ...||||   |   .|  | |.||||  .|..| |       ....|.    .. 
VYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQSIKLDWPLIKRA

TQIIRDIAAGMAYLHS--FPIIHRNLIPSNVLIGEKMNAKVSDFGL
 .. .|.| ||..||.    |||| | ..| |. . ...||.||||
MRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGL
Kinase AqueK646.AA Dicty4-Unclassified 789-912 36 1.2e-22 74.37 In-house 24-155 (263) Show / Hide 
Range on Protein: 789-912
Range on HMM: 24-155/263
Sequence Identity: 36% (48 aa)

DVVVKKINRPPDVWECCTRKTFQKEVEQLSRLQCPYVVQFMGAIMVP--SSGLYCLVMEYMPNNDLHTLMH---VKKTQLSKLEKTQIIR---DIAAGMA
|| |||.|   .       . | |||| |  .| |  |.  |. . |      .| ||| |.   |  . |     . |  ||. | ||.   ||| ||.
DVAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPSEQQQPIKLDDTLIIKYAFDIAQGMQ

YLHSFPIIHRNLIPSNVLIGEKMNAKVSDFGL
.||.  .||| .  ||.|.    |.|. |||.
HLHTRNFIHRDIKSSNILMDKHFNIKIADFGI
Kinase AqueK646.AA Pkinase 780-912 26 6.2e-22 78.64 Pfam 15-158 (293) Show / Hide 
Range on Protein: 780-912
Range on HMM: 15-158/293
Sequence Identity: 26% (38 aa)

VYLGTFRSID--VVVKKINRPPDVWECCTRKTFQKEVEQLSRLQCPYVVQFMGAIMVPSSGLYCLVMEYMPNN----DLHTLMH-VKKTQL--SKLEKTQ
||... ..    |.||.|... . .... ...   |.. . ||..|..|.. .. .   .. ...||||...     ||.....  ... .  |  |   
VYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKF

IIRDIAAGMAYLHSFPIIHRNLIPSNVLIGEKMNA----KVSDFGL
... |. |..|.||  |||| | |.|.|| ....     |..||||
YMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGL
Kinase AqueK646.AA LRRK 809-912 34 4.4e-21 71.31 In-house 103-224 (351) Show / Hide 
Range on Protein: 809-912
Range on HMM: 103-224/351
Sequence Identity: 34% (43 aa)

TFQKEVEQLSRLQCPYVVQFMGAIMVPSSGLYCLVMEYMPNNDLHTLMHVKK-TQ-------LSKLEKTQIIRDIAAGMAYLHSFP--IIHRNLIPSNVL
.|..||  .|.|. |..|. .|  . |    .|.||||.|. ||....| || ..       .|   | .|  .|| ||.||||.   ||||.| . |.|
EFRHEVWIMSHLNHPNIVSLKGFCIHP----LCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNIL

I-----G-------EKMNAKVSDFGL
.     .       . ..||..|||.
LWSSPQNHSPNYPNAHVCAKIADFGI
Kinase AqueK646.AA MLK 779-912 26 4.5e-21 69.93 In-house 14-179 (291) Show / Hide 
Range on Protein: 779-912
Range on HMM: 14-179/291
Sequence Identity: 26% (45 aa)

DVYLGTFRSID-----VVVKKIN---RPPDVWECCTRKTFQKEVEQLSRLQCPY----VVQFMGAIMVPSSGLYCLVMEYMPNNDLHTLMHVKKT-----
.|..|..|  |     | ||...   .   . . | .. |..|...|..|. |     ..||.|..  |    .|.||||...  |... | ...     
KVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPP-CHFCIVMEYCEGGSLYNVLHGARSKWMDA

--------QLSKLEKTQIIRDIAAGMAYLHS-FP--IIHRNLIPSNVLIGE------KMNAKVSDFGL
          .   . ..  ..| ||.||||  |  |||| | ..|.|| |      ....|..|||.
NHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGT
Kinase AqueK646.AA Dicty4 937-1032 32 5.6e-18 56.7 In-house 181-277 (277) Show / Hide 
Range on Protein: 937-1032
Range on HMM: 181-277/277
Sequence Identity: 32% (32 aa)

PYYRAPEIIEKNDFSTASDVYSFGIMLHELATQKRPFS-DVDPCSNAMVWVMKLLMGARPVIPSYLEPSCKQMMARLWHADPSMRPTFKEFLVK--CEE
| . |||.  .. .  ..|||||||.| |..| . |..   .|  ..   |     . || ||..  || |. ... |. ||. ||.|.| . .   |.
PCWMAPEVMMHQPYNEKADVYSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCN--KKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase AqueK646.AA MLK 939-1030 31 3.1e-17 56.44 In-house 199-291 (291) Show / Hide 
Range on Protein: 939-1030
Range on HMM: 199-291/291
Sequence Identity: 31% (30 aa)

YRAPEII---EKNDFSTASDVYSFGIMLHELATQKRPFS-DVDPCSNAMVWVMKLLMGARPVIPSYLEPSCKQMMARLWHADPSMRPTFKEFLVKC
..|||.|   . . .| ..||.|.|..| |. | . |.. ..||   |.  ... |   || |||   .. |..| . |..||. ||.|.. . . 
WMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGL---RPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase AqueK646.AA LRRK 937-1032 26 6.6e-17 56.34 In-house 243-351 (351) Show / Hide 
Range on Protein: 937-1032
Range on HMM: 243-351/351
Sequence Identity: 26% (29 aa)

PYYRAPEIIEKN---DFSTASDVYSFGIMLHELATQK-RPFSDVD-PCSNAMVWVMKL--LMGARPVIP-S-YLE----PSCKQMMARLWHADPSMRPTF
| ..||||. .|    ... .|.||||. |.|| | . .|| . | .    .    ..  . | ||.|| . ...    ..... .   |..||  ||.|
PGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQIEDKIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHF

KEFLVKCEE
 . . . ..
SQIVKRLSQ
Kinase AqueK646.AA Pkinase 937-1027 20 4.3e-16 57.99 Pfam 175-288 (293) Show / Hide 
Range on Protein: 937-1027
Range on HMM: 175-288/293
Sequence Identity: 20% (23 aa)

PYYRAPEIIE-KNDFSTASDVYSFGIMLHELATQKRPFSDV--DPCSNAMVWVMKLLMGARPVIPSYLE---------------------PSCKQMMARL
|.|.|||.|   .. ....|..|.|..|.|... . ||..   ..  . . ..... ||...  ... .                     ..||. . ..
PWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWC

WHADPSMRPTFKEFL
.. ||. |||... |
LCKDPKKRPTAEQIL
Kinase AqueK646.AA Dicty4-Unclassified 941-1030 31 3.1e-15 48.58 In-house 176-263 (263) Show / Hide 
Range on Protein: 941-1030
Range on HMM: 176-263/263
Sequence Identity: 31% (29 aa)

APEIIEKNDFSTASDVYSFGIMLHELATQKRPFSDVD-PCSNAMVWVMKLLMGARPVIPSYLEPSCKQMMARLWHADPSMRPTFKEFLVKC
.||.     .  .|||||...|| ||||   |. ..  .   |     | |   || ||.  ..  |..    || ||  |||. .   . 
SPECLMHESYNQKSDVYSYAMMLYELATGDEPYQEIQSIMNAARSVCDKKL---RPKIPDNCDNFWKKLIKWCWHNDPNKRPTMNQIIQYL
Kinase AqueK646.AA Pkinase_Tyr 941-1025 31 4.6e-10 34.71 Pfam 182-265 (270) Show / Hide 
Range on Protein: 941-1025
Range on HMM: 182-265/270
Sequence Identity: 31% (28 aa)

APEIIEKNDFSTASDVYSFGIMLHELAT-QKRP-FSDVDPCSNAMVWV-MKLLMGARPVIPSYLEPSCKQMMARLWHADPSMRPTFKE
||| |  . |.|.|||.|||. . |. |  . | . .. . .  . ..  .   | |  .| .  .   ..| . ||.||..||||.|
APECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGM-SNEEVYEYIYED---GYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSE