Gene AqueK626 (A.queenslandica)

AqueK626

Species: A.queenslandica
Alias: AqueK626
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: HH498

Sequence

Name Sequence Type Origin Length Description Download
AqueK626.AA Protein None 329 None Fasta, JSON
AqueK626.kin_dom Protein Kinase Domain None 121 None Fasta, JSON

Protein domain

Protein domains of AqueK626.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK626.AA TKL 209-329 22 3e-24 84.22 In-house 1-171 (364) Show / Hide 
Range on Protein: 209-329
Range on HMM: 1-171/364
Sequence Identity: 22% (40 aa)

LGKGGWGEVKVADFRG----------LKVAAKCLYEVIISPYNI-------------------------GTFSREMNIASKIRHPNLLQFIGATTEGN--
.|.|| |||  . .||            || | . .   .  ..                          .. .|... |..||||..||.|. ....  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------PIILTELM-PTSLRKELESGGVAYPAILSISLDVACALNYLHLFKP-----HPILHRDVSSANV
            . | .|..   ||.  |       . .....||.|...||||  .|      ||.|||  |.|.
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNI
Kinase AqueK626.AA CZAK 206-329 35 9e-19 64.91 In-house 4-140 (279) Show / Hide 
Range on Protein: 206-329
Range on HMM: 4-140/279
Sequence Identity: 35% (50 aa)

EVVLGKGGWGEVKVADFRGLKVAAKCLYEVIISPYNIGT------FSREMNIASKIRHPNLLQFIGATTEGN---PIILTELMP-TSLRKELE--SGGVA
. . |.|  |||. |  ||  || | ..   ..  |         | .|  | || .||| .||.|| .|..     | .| |   |||. |   .  . 
GQTIGQGFFGEVYKAYWRGKDVAIKIIH--RNQFRNKDENKEENMFQKEVSIMSKLCHPNCVQFLGACSEDGPNHHCIVMEWMGGGSLRRLLTDHYFYHK

Y-PAI-LSISLDVACALNYLHL-FKPHPILHRDVSSANV
  | . ... .|.|   ||||  .|| |||||| || |.
QNPHLQWNMAIDIARGMNYLHDNWKPNPILHRDLSSRNI
Kinase AqueK626.AA Dicty4 205-328 32 3.5e-15 47.23 In-house 3-144 (277) Show / Hide 
Range on Protein: 205-328
Range on HMM: 3-144/277
Sequence Identity: 32% (46 aa)

TEVVLGKGGWGEVKVADFRGLKVAAKCL--YEVIISPYNIGTFSREMNIASKIRHPNLLQFIGATT-----EGNPIILTELM-PTSLRKELES------G
.|. .|||. |||  .  || .|| | |    .  . . .  | .| .| .||||||...| || |      | . | ||.|  ..| . | .       
IEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQ

GVAYP--AILS---ISLDVACALNYLHLFKPHPILHRDVSSAN
 .  .   |..   . .|.|  .|.||   |  |.|||  |.|
SIKLDWPLIKRAMRMAFDAARGMNWLHCCNPV-IIHRDLKSHN
Kinase AqueK626.AA MLK 203-329 21 3.9e-14 45.55 In-house 1-158 (291) Show / Hide 
Range on Protein: 203-329
Range on HMM: 1-158/291
Sequence Identity: 21% (34 aa)

TMTEVVLGKGGWGEVKVADFRGLKVAAKC--LYEVIISPYNIGT-------FSREMNIASKIRHPN----LLQFIGATTE-GN-PIILTELMPT-SLRKE
  .. ..|.|. |.|  . .|.  . ||   ...| .... ..        | .| .......|||      || |. .. ..   |..| ..  ||   
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

LESG---------------GVAYPAILSISLDVACALNYLHLFKPHPILHRDVSSANV
| ..                .    .....|..| ...|||  .|.|| |||  | |.
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNI
Kinase AqueK626.AA DRK 204-328 34 8.2e-13 39.76 In-house 2-130 (258) Show / Hide 
Range on Protein: 204-328
Range on HMM: 2-130/258
Sequence Identity: 34% (45 aa)

MTEVVLGKGGWGEVKVADFRGLKVAAKCLYEVIIS-PYNIGTFSREMNIASKIRHPNLLQFIGATTE-GNPIILTELMPT-SLRKEL--ESGGVAYPAIL
   .  |.|..|||     || .|| | |    |     .  | || |. .. ||||  ||.|. ..   . | .| ||  || . |  ||     | ..
KIGNRIGRGNYGEVFRGTWRGTQVAVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESIEMDWPLMK

SISLDVACALNYLHLFKPHPILHRDVSSAN
.. .|.|  ..|||   |  |.|||  | |
QMMFDCAKGMIYLHCCNPI-IIHRDLKSHN
Kinase AqueK626.AA TKL-Unique 208-329 26 4.9e-12 38.91 In-house 4-143 (290) Show / Hide 
Range on Protein: 208-329
Range on HMM: 4-143/290
Sequence Identity: 26% (38 aa)

VLGKGGWGEVKVADFRGLKVAAKCLY-EVIISPYNIGTFSREMNIASKIR-HPNLLQFIGATT-----EGNPIILTELMPT-SLRKELE-----------
..| || |.|. . .|| .|| | .  .  .|.  . .|..| |. .|.. |||.....|...     ..| .| .| .|  ||.. |            
KIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNN

SGGVAYPAILSISLDVACALNYLHLFKPHPILHRDVSSANV
.    .  .... .|.| ...|||  .|  |.|||  | |.
NCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNF
Pkinase_Tyr AqueK626.AA Pkinase_Tyr 202-329 25 1.1e-10 36.8 Pfam 1-142 (270) Show / Hide 
Range on Protein: 202-329
Range on HMM: 1-142/270
Sequence Identity: 25% (37 aa)

ITMTEVVLGKGGWGEVKVADFR------GLKVAAKCLYEVIISPYN--IGTFSREMNIASKI-RHPNLLQFIGATT-EGNP---IILTELMPT-SLRKEL
||. .. ||.|  |||. .  .      ...|| |.|     .. .  .  | ||..| ... .|||.....|. | .| |   .| .|.||  .|.. |
ITFGKK-LGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

ESG-----GVAYPAILSISLDVACALNYLHLFKPHPILHRDVSSANV
 .       .  . .|......|....||.  .   . |||.   |.
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNC
Kinase AqueK626.AA LISK 208-266 29 2.1e-10 29.79 In-house 1-64 (296) Show / Hide 
Range on Protein: 208-266
Range on HMM: 1-64/296
Sequence Identity: 29% (19 aa)

VLGKGGWGEVKVADFR--GLKVAAKCLY---EVIISPYNIGTFSREMNIASKIRHPNLLQFIGA
..|||. |.|     |  |  .| | .    .. . | .. .. ||. .  ..|||| .||.|.
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGV
Kinase AqueK626.AA Dicty5 240-329 27 4.2e-10 30.95 In-house 38-135 (260) Show / Hide 
Range on Protein: 240-329
Range on HMM: 38-135/260
Sequence Identity: 27% (28 aa)

YNIGTFSREMNIASKIR--HPNLLQFIGATTEGNPI--ILTELMPT-SLRKELESGGV------AYPAILSISLDVACALNYLHLFKPHPILHRDVSSAN
...  | ||  | | .   |||.  . || .       ..||.    ||.  |           ||. .|.. .|.| .. .||      | |||. | |
FDWNEFYREVTIMSIFQSDHPNFIRCYGAHQYNDKYPFHVTEYCHNGSLFNYLNDQRKTTGQPIAYFQQLHMAIDIAQSMRHLHSMN---IIHRDLKSMN

V
.
F
Kinase AqueK626.AA Shk 205-280 39 7.9e-10 31.72 In-house 3-80 (269) Show / Hide 
Range on Protein: 205-280
Range on HMM: 3-80/269
Sequence Identity: 39% (31 aa)

TEVVLGKGGWGEVKVADFRGLKVAAKCLYEVIISPYNIGTFSREMNIASKIRHPNLLQFIGATT--EGNPIILTELMP
.|  || |  | |  .  || .|| | .     . .    |  |  | |||.|||.. | || |   |   | |||||
REDFLGQGSFGKVYKGRCRGKEVAVKVMHKQNFDENTMTSFRKEVHIMSKIFHPNICLFMGACTSQPGKCMIVTELMP
Kinase AqueK626.AA TK 247-329 12 1e-09 27.93 In-house 87-271 (486) Show / Hide 
Range on Protein: 247-329
Range on HMM: 87-271/486
Sequence Identity: 12% (24 aa)

REMNIASKIR-----HPNLLQFIGATTEGN-------------PIILTELMP-TS----LRKELESGG--------------------------------
.|...... .     |||.....|. |.|              ..|..|.||  .    ||. | .                                  
EEAEEMKMMCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITY

---------------------------------------------VAYPAILSISLDVACALNYLHLFKPHPI----LHRDVSSANV
                                             .  .  | .....||.. |||  .         |||.   |.
SHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCE-FIQNFVHRDLAARNC
Kinase AqueK626.AA Pkinase 203-324 18 2.8e-09 33.87 Pfam 1-134 (293) Show / Hide 
Range on Protein: 203-324
Range on HMM: 1-134/293
Sequence Identity: 18% (25 aa)

TMTEVVLGKGGWGEVKVADFRGLK--VAAKCLYEVIISPYNIGTFSR--EMNIASKIRHPNLLQFIGAT-TEGNPIILTELMPT-----SLRKELE---S
  .. ..|.|. |.|. .  .|    || |..  . ...    |  |  |  |  ...||| ......  ..... . .|...      .|   ..   .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GGV--AYPAILSISLDVACALNYLHLFKPHPILHRDV
|..   .  . .. . ....|.|.|      |.|||.
GCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDL
Kinase AqueK626.AA S_TKc 203-320 10 0.000745 -120.39 SMART 1-231 (231) Show / Hide 
Range on Protein: 203-320
Range on HMM: 1-231/231
Sequence Identity: 10% (25 aa)

TMTEVVLGKGGWGEVKVADFRG--LKVAAKCLYEVIISPYNIGTFSREMNIASKIRHPNLLQFIGATTEGNPIILTELMPT---SLRKELESGG------
     ..|||. |.|. .  ..   .|| |..           .. ||..| .| .|||. .....  ...  . .|....   .|.. ... |      
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-VAYPAILSISLDVACALNYLH------------------------------------------------------------------------------
      . ..   ..|||.|.|                                                                              
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDEHIKICDFGLARQLTTFCGTPWYMAPEVLGYGKCKCDWWSCGCILYEMLCGYPPFPQMQMM

---------------LFKP-------------------HPIL
               ...                    || .
FKKIGSPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF
TyrKc AqueK626.AA TyrKc 202-329 13 0.000789 -160.71 SMART 1-280 (280) Show / Hide 
Range on Protein: 202-329
Range on HMM: 1-280/280
Sequence Identity: 13% (38 aa)

ITMTEVVLGKGGWGEVKVADFRGLKVAAKCLYEVIISPYNIGTFSREMNIASKI--RHPNLLQFIGATTE--------GNPIILTELMPT-SLRKELESG
||. . .|| |  |||  .  . ..|| |.| |       .  | ||..| .|.  .|||.....|. |.        . . |..|.||  .|.. | . 
ITLGK-KLGEGAFGEVYKGTWK-IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

G--VAYPAILSISLDVACALNYLH---------------LFKPH-----------PILHR--------DVS-----SAN---------------------
.  .  .  ||.....||  .|||               . ..|            | .           .     ...                     
RPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTK

--------------------------------------------------------------------------------------V
                                                                                       
SDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase AqueK626.AA LISK 298-329 43 0.006078 5.17 In-house 104-132 (296) Show / Hide 
Range on Protein: 298-329
Range on HMM: 104-132/296
Sequence Identity: 43% (14 aa)

LSISLDVACALNYLHLFKPHPILHRDVSSANV
..|.||.||.. |||  .   |.|||  | |.
VKIALDIACGMSYLHSMN---IIHRDLKSKNC