Gene AqueK593 (A.queenslandica)
AqueK593
Species: A.queenslandica
Alias: AqueK593
External Links:
Annotation:
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| AqueK593.AA | Protein | None | 204 | None | Fasta, JSON |
| AqueK593.kin_dom | Protein Kinase Domain | None | 195 | None | Fasta, JSON |
Protein domains of AqueK593.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | AqueK593.AA | TKL | 1-199 | 21 | 7.1e-39 | 135.48 | In-house | 76-364 (364) | Show / Hide |
Range on Protein: 1-199 Range on HMM: 76-364/364 Sequence Identity: 21% (62 aa) MSIASRVRHPNLVQFIGATK--------------VGNPLILTELM-STSLNHEIRRNRLSNEEILSIAQDVALGLNYLHLFKP-----EPIIHRDVSSPN . . || ||||.|||.|. . |.. | .|.. || | . . ....|.|.|.|.|||| .| |||||| |.| IMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKN VLLKRCSG---------AAGYEAKVADYGTAKVV-------------------QANSTSTGTVMPGNVAYAAREARDPE----------------QHSPA .|... .| . .|..|.|..... | |. .| |. .. | |. . . . |.. ILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQ-NNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEK MDVYSYSVLLMEMNLRSQPEMTIAERARQ---------SGSV-----------------------SWSDMKSLIQRGLKADPRARPTMAQVVESL .||||. ..| |. | .|. . .. .. .. . . .||.|.|. ..||..||.. .... | CDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL |
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| Kinase | AqueK593.AA | MLK | 3-149 | 26 | 9e-24 | 79.42 | In-house | 58-229 (291) | Show / Hide |
Range on Protein: 3-149 Range on HMM: 58-229/291 Sequence Identity: 26% (45 aa) IASRVRHPN----LVQFIGA-TKVGN-PLILTELMST-SLNHEIRRNR---------------LSNEEILSIAQDVALGLNYLHLFKPEPIIHRDVSSPN ......||| .|| |. .. .. .|..| .. ||.. .. .| . . ....| ..| |..||| .| |||||| |.| HLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHN VLLKR-CSGAAGYEAKVADYGTAKVVQANSTSTGTVMPGNVAYAAREAR---DPEQHSPAMDVYSYSVLLMEM .|. . |. .. .|..| ||.. .. . .. . ..|..|. | |.. |. | . ||.|. |.| || ILIDEICHDMHHGTLKICDFGTSRDWHQMC-TNMMSNAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEM |
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| Kinase | AqueK593.AA | TK | 8-199 | 13 | 4e-20 | 63.47 | In-house | 101-486 (486) | Show / Hide |
Range on Protein: 8-199
Range on HMM: 101-486/486
Sequence Identity: 13% (54 aa)
RHPNLVQFIG-ATKVGN------------PLILTELMS-TS----LNHEIRRNR----------------------------------------------
.|||.|...| |.... ..|..|.|. . | . |..|
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY
-------------------------------LSNEEILSIAQDVALGLNYLHLFKPEPI----IHRDVSSPNVLLKRCSGAA------GYEAKVADYG--
|. .. | .....| |. ||| . | .|||. |.|. . . |. .|.||.|
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCE-FIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS
------TAKVVQANSTSTGTVMPGN-------------------------VAYAAREARD---------PEQHSPAMDVYSYSVLLMEMNL--RSQPE--
|. .. .. . . .| . . | |. . .... ||.|. ||. |. . ..
RQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGG
MTI------------------------------AERARQS--GSVS-W------------SDMKSLIQRGLKADPRARPTMAQVVESL
|. .| |. . | .. |.|. ..||. |||..|..| |
MSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
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| Kinase | AqueK593.AA | TKL-Unique | 2-149 | 25 | 4.3e-20 | 67.69 | In-house | 47-221 (290) | Show / Hide |
Range on Protein: 2-149 Range on HMM: 47-221/290 Sequence Identity: 25% (45 aa) SIASRVR-HPNLVQFIGATK---VGNP--LILTELMS----TSLNHE--------IRRNRLSNEEILSIAQDVALGLNYLHLFKPEPIIHRDVSSPNVLL .. .. . |||.|...|... | .| | .| .. .. | .. . |... ....|.|.|.|..||| .| ||||| |.|.|. NWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLV KRCSGAAGYEAKVADYGTAKVVQANSTSTGT--------VMPGNVAYAAREARDP--EQHSPAMDVYSYSVLLMEM . | | . .|..| |..|. ....| . . |. ..| | .| | ||||... | |. DNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQYSEKSDVYSFGIVLWEI |
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| Kinase | AqueK593.AA | CZAK | 50-149 | 30 | 9.7e-16 | 53.77 | In-house | 108-215 (279) | Show / Hide |
Range on Protein: 50-149 Range on HMM: 108-215/279 Sequence Identity: 30% (34 aa) LSIAQDVALGLNYLHL-FKPEPIIHRDVSSPNVLLKRCSG--------AAGYEAKVADYGTAKVVQANSTS-TGTVMPGNVAYAAREARDPEQHSPAMDV ...| |.| | |||| .|| ||.||| || |.|| .|..|.| . . | |. | ... | | | .. || WNMAIDIARGMNYLHDNWKPNPILHRDLSSRNILLDHSYTPKNPVVSSRQDIICKINDFGLSREMMEQPFEMTQTM--GCLCWMAPECFKGENYTEKVDV YSYSVLLMEM ||. .| .. YSFGMILWCI |
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| Kinase | AqueK593.AA | TK-Unique | 8-149 | 22 | 1.3e-14 | 46.92 | In-house | 62-232 (294) | Show / Hide |
Range on Protein: 8-149 Range on HMM: 62-232/294 Sequence Identity: 22% (41 aa) RHPNLVQFIGATK-VG-NPLILTELMSTS-LNHEIRRNR---------------------------LSNEEILSIAQDVALGLNYLHLFKPEPIIHRDVS .|||.||..|.. . ...|. | .. . | | .|..| .| . ...| ..| |..||. .. |.|||.. DHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQ-RKKIVHRDLC SPNVLLKRCSGAAGYEAKVADYGTAK-----VVQANSTSTGTVMPGNVAYAAREARD--PEQH-SPAMDVYSYSVLLMEM . |||| . ....|..|.| |. |.....| |... ... | |. ... .. ||.|. ||. |. ARNVLLTE-----DKVCKICDFGMARDVYTNGVYSMMCSQGRIP---IRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEI |
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| Kinase | AqueK593.AA | Dicty4 | 5-75 | 31 | 9.6e-14 | 42.39 | In-house | 53-139 (277) | Show / Hide |
Range on Protein: 5-75 Range on HMM: 53-139/277 Sequence Identity: 31% (28 aa) SRVRHPNLVQFIGA-T----KVGNPLILTELM-STSLNHEIRR------NRLSNE--EILS---IAQDVALGLNYLHLFKPEPIIHRD . ||||...| || | . | ..| ||.| ...| .. . . . |.. .| |.|.|.|.|| | ||||| CKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPV-IIHRD |
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| Kinase | AqueK593.AA | Dicty4-Unclassified | 7-149 | 28 | 1.3e-13 | 42.91 | In-house | 55-201 (263) | Show / Hide |
Range on Protein: 7-149 Range on HMM: 55-201/263 Sequence Identity: 28% (45 aa) VRHPNLVQFIGATKVGNP-------LILTELM-STSLNHEIR-----RNR-LSNEE--ILSIAQDVALGLNYLHLFKPEPIIHRDVSSPNVLLKRCSGAA . |||||. |. || | .|.| . | | ... .. .. |. .| |.| |. .|| .||||. | |.|. . IQHPNLVKCYGYCI--NPRSHKSTMCIVMEFMHKGNLFEVIHSKPSEQQQPIKLDDTLIIKYAFDIAQGMQHLHTRN---FIHRDIKSSNILMDKH---- GYEAKVADYGTAKVVQANSTSTGTVMPGNVAYAAREARDPEQHSPAMDVYSYSVLLMEM . .|.|| | . |. | . | |. | .. . | | . ||||| ..| |. -FNIKIADFGISRVIDFNFNMT-TIA-GTPKWESPECLMHESYNQKSDVYSYAMMLYEL |
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| Kinase | AqueK593.AA | HH498 | 49-149 | 37 | 9.5e-13 | 36.34 | In-house | 123-219 (284) | Show / Hide |
Range on Protein: 49-149 Range on HMM: 123-219/284 Sequence Identity: 37% (38 aa) ILSIAQDVALGLNYLHLFKPEPIIHRDVSSPNVLLKRCSGAAGYEAKVADYGTAKVVQANSTSTGTVMPGNVAYAAREARD-PEQHSPAMDVYSYSVLLM .. |. ||| | |||| . |||||| | |.|. . | |.|||.| |. . | ||| . | | . | ||.|| . KMTISVDVAHGMNYLHNSLKHPIIHRDLNSHNILIHE----DGH-AVVADFGESRFVCDMHDDNMTKQPGNLRWMAPEVFSQCQKYSIKVDVFSYAMCIW EM || EM |
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| Kinase | AqueK593.AA | Pkinase_Tyr | 8-100 | 26 | 3.2e-12 | 42.03 | Pfam | 62-156 (270) | Show / Hide |
Range on Protein: 8-100 Range on HMM: 62-156/270 Sequence Identity: 26% (27 aa) RHPNLVQFIGATK-VGNP---LILTELMST-SLNHEIRRN-----RLSNEEILSIAQDVALGLNYLHLFKPEPIIHRDVSSPNVLLKRCSGAAGYEAKVA .|||.|...|. | | .| .|.| .| . |.. .|. ...|......| |..||. . .||||. |.|... . .|.. HHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTE-----NNVVKIC DYG | | DFG |
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| Kinase | AqueK593.AA | S_TKc | 1-202 | 16 | 9.1e-12 | -4.33 | SMART | 19-231 (231) | Show / Hide |
Range on Protein: 1-202
Range on HMM: 19-231/231
Sequence Identity: 16% (40 aa)
MSIA---------------------SRVRHPNLVQFIGATKVGNPLILTELMST---SLNHEIRRNR-------LSNEEILSIAQDVALGLNYLHLFKPE
. .. .|||.|..... .. . .|.... .| . |.... .. .. .... ....|.|.| .
RHKKTGRIVAIKIIKEHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHG--
PIIHRDVSSPNVLLKRCSGAAGYEAKVADYGTAKVVQANSTSTGTVMPGNVAYAAREARDPEQHSP-AMDVYSYSVLLMEMNLRSQ---PEMTIAERARQ
|||||. |.|| . . |..| | |... | . | | | | .... . |..| ..| || . .... .. .
-IIHRDLKPENILLDE-------HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFPQMQMMFKKIG-
SGSVSWSDMKSLIQRGLKADPRARPTMAQVVE------SLKRM
...|..|.. |. ||. ||| .. . . .
-----SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | AqueK593.AA | LRRK | 52-114 | 34 | 1.9e-11 | 36.75 | In-house | 169-242 (351) | Show / Hide |
Range on Protein: 52-114 Range on HMM: 169-242/351 Sequence Identity: 34% (26 aa) IAQDVALGLNYLHLFKPEPIIHRDVSSPNVLLKRCS-GA------AGYEAKVADYGTAK----VVQA-NSTSTGT || ..| |..||| ..| |||||| |||.||.. . . | . ||.||.|. . . ....|. IALQIAKGMEYLHSHNP-PIIHRDLKSPNILLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGN |
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| Kinase | AqueK593.AA | TyrKc | 1-199 | 15 | 3.7e-10 | -58.4 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 1-199 Range on HMM: 1-280/280 Sequence Identity: 15% (45 aa) MSIA----------------------------------------SRV--RHPNLVQFIGATKV--------GNPLILTELMST-SLNHEIRRNR--LSNE . ... .|||.|...|. . ..|..|.|. .|.. .|..| |... ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMK EILSIAQDVALGLNYLHLFKPEPIIHRDVSSPNVLLKRCSGAAGYEAKVADYGTAKVVQAN--------STST----GTVMPGNVAYAAREARDPEQHSP . ||.. ..| | .||| ..|||| |.|. .... .|..| | .. . .. |. .. . | |. . .. DLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLV-----GENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTT AMDVYSYSVLLME----------------MNLRSQPEMTIAERARQSGSV--------SWSDMKSLIQRGLKADPRARPTMAQVVESL . ||.|. |.. | |. . | . . . ..| ..... ..|| |||.....| . KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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| Kinase | AqueK593.AA | Pkinase | 6-149 | 23 | 2.5e-08 | 30.52 | Pfam | 56-205 (293) | Show / Hide |
Range on Protein: 6-149 Range on HMM: 56-205/293 Sequence Identity: 23% (38 aa) RVRHPNLVQFIGATK-VGNPLILTELMST-----SLNHEIR---RNRL--SNEEILSIAQDVALGLNYLHLFKPEPIIHRDVSSPNVLLKRCSGAAGYEA |..||| |..... ... . .|.. .| . |. .... | .|. ... .. ||.|.| |||||. . |.|.. | . RLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILID-NNGHIDACV KVADYGTAKVVQANSTSTGTVMPGNVA---YAAREA-RDPEQHSPAMDVYSYSVLLMEM |..| | ||... . .. | . . |.| | |. . ..|. |..|. ..| || KICDFGLAKQFD---Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEM |
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| Kinase | AqueK593.AA | MLK | 174-199 | 34 | 2.6e-07 | 21.56 | In-house | 266-291 (291) | Show / Hide |
Range on Protein: 174-199 Range on HMM: 266-291/291 Sequence Identity: 34% (9 aa) MKSLIQRGLKADPRARPTMAQVVESL .|.|... ..||. ||...|.|. | WKKLMKQCWNQDPHKRPSFRQIVQHL |
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| Kinase | AqueK593.AA | LRRK | 171-201 | 35 | 6e-06 | 17.13 | In-house | 321-351 (351) | Show / Hide |
Range on Protein: 171-201 Range on HMM: 321-351/351 Sequence Identity: 35% (11 aa) WSDMKSLIQRGLKADPRARPTMAQVVESLKR | ....||| ..||. ||.. |.|. |. WHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ |
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| Kinase | AqueK593.AA | Dicty4-Unclassified | 174-199 | 42 | 0.000139 | 11.58 | In-house | 238-263 (263) | Show / Hide |
Range on Protein: 174-199 Range on HMM: 238-263/263 Sequence Identity: 42% (11 aa) MKSLIQRGLKADPRARPTMAQVVESL .|.|| . ||. |||| |... | WKKLIKWCWHNDPNKRPTMNQIIQYL |
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| Kinase | AqueK593.AA | CZAK | 2-31 | 42 | 0.000228 | 11.95 | In-house | 52-84 (279) | Show / Hide |
Range on Protein: 2-31 Range on HMM: 52-84/279 Sequence Identity: 42% (14 aa) SIASRVRHPNLVQFIGATKVGN---PLILTELM || | .||| |||.|| .. | .| | SIMSKLCHPNCVQFLGACSEDGPNHHCIVMEWM |
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| Kinase | AqueK593.AA | Dicty4 | 175-201 | 31 | 0.000238 | 10.61 | In-house | 249-277 (277) | Show / Hide |
Range on Protein: 175-201 Range on HMM: 249-277/277 Sequence Identity: 31% (9 aa) KSLIQRGLKADPRARPTMAQVVES--LKR |.|||. . || ||....... | KHLIQWCWDHDPQHRPSFEEIIQRRILEH |
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| Kinase | AqueK593.AA | HH498 | 176-199 | 37 | 0.000265 | 9.11 | In-house | 261-284 (284) | Show / Hide |
Range on Protein: 176-199 Range on HMM: 261-284/284 Sequence Identity: 37% (9 aa) SLIQRGLKADPRARPTMAQVVESL .|||.. . | ||. .|.| | NLIQMCWHPCPENRPDFDQIVTIL |
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| Kinase | AqueK593.AA | TKL-Unique | 177-199 | 34 | 0.000549 | 10.16 | In-house | 268-290 (290) | Show / Hide |
Range on Protein: 177-199 Range on HMM: 268-290/290 Sequence Identity: 34% (8 aa) LIQRGLKADPRARPTMAQVVESL |||.. . || ||. .....| LIQQCWHHDPSQRPSFDEIIHRL |
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| Kinase | AqueK593.AA | TK-Unique | 165-199 | 22 | 0.025535 | 3.95 | In-house | 260-294 (294) | Show / Hide |
Range on Protein: 165-199 Range on HMM: 260-294/294 Sequence Identity: 22% (8 aa) QSGSVSWSDMKSLIQRGLKADPRARPTMAQVVESL | ... .| .|... .. .| ||. .|.. | QPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL |
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| Kinase | AqueK593.AA | Pkinase_Tyr | 171-199 | 27 | 0.02749 | 8.37 | Pfam | 242-270 (270) | Show / Hide |
Range on Protein: 171-199 Range on HMM: 242-270/270 Sequence Identity: 27% (8 aa) WSDMKSLIQRGLKADPRARPTMAQVVESL . .. .|... ..|| |||.....| | PDEIYDLMKQCWHYDPEDRPTFSEIHEQL |
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| Kinase | AqueK593.AA | Pkinase | 168-199 | 22 | 0.115863 | 6.96 | Pfam | 244-293 (293) | Show / Hide |
Range on Protein: 168-199 Range on HMM: 244-293/293 Sequence Identity: 22% (11 aa) SVSW----------------SDMKSLIQRGLKADPRARPTMAQVVES--L |.|. ...|..| . |. || ||| .|.... . SISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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| Kinase | AqueK593.AA | HH498 | 2-19 | 50 | 0.164467 | 0.1 | In-house | 54-71 (284) | Show / Hide |
Range on Protein: 2-19 Range on HMM: 54-71/284 Sequence Identity: 50% (9 aa) SIASRVRHPNLVQFIGAT || .| ||. |||..|. SIMCRLNHPCVVQFVYAC |
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| Kinase | AqueK593.AA | Pkinase_Tyr | 138-149 | 50 | 7.917708 | 0.04 | Pfam | 196-207 (270) | Show / Hide |
Range on Protein: 138-149 Range on HMM: 196-207/270 Sequence Identity: 50% (6 aa) DVYSYSVLLMEM ||.|. ||. |. DVWSFGVLMWEI |
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