Gene AqueK588 (A.queenslandica)

AqueK588

Species: A.queenslandica
Alias: AqueK588
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: HH-C

Sequence

Name Sequence Type Origin Length Description Download
AqueK588.AA Protein None 202 None Fasta, JSON
AqueK588.kin_dom Protein Kinase Domain None 193 None Fasta, JSON

Protein domain

Protein domains of AqueK588.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK588.AA TKL 1-197 19 6.9e-37 128.88 In-house 76-364 (364) Show / Hide 
Range on Protein: 1-197
Range on HMM: 76-364/364
Sequence Identity: 19% (57 aa)

MSIASRVRHPKLVQFIGATK--------------VGNPLILTELM-SISLYKKLQETELTNQQILSIAQDVALGLNYLHLFKP-----QPIIHRDVGSPN
. . || ||| .|||.|. .               |.. | .|..   ||.  |.      .|....|.|.|.|.||||  .|      ||||||  |.|
IMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKN

VLLKPCTGP---------AGYEAKVADYGTAKVVQAEN--------------------IGTVMPGNVAYAAPEARDPD----------------QHSPAM
.|..    .         | . .|..|.|...... ..                          |. .. |||. . .                . |...
ILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKC

DVYSYSVLLMEMTLCSQPEMTTAEREVQ---------SGSV-----------------------SWSDIKSLIQRGLNANPRTRPTMAQVIDSL
||||. ..| |.  . .|.    .....         .. .                        . ..|.|.|.  ...|. ||.. .... |
DVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase AqueK588.AA MLK 3-147 26 5.3e-22 73.21 In-house 58-229 (291) Show / Hide 
Range on Protein: 3-147
Range on HMM: 58-229/291
Sequence Identity: 26% (45 aa)

IASRVRHPK----LVQFIGA-TKVGN-PLILTELMSI-SLYKKLQETE---------------LTNQQILSIAQDVALGLNYLHLFKPQPIIHRDVGSPN
......||      .|| |. .. ..  .|..| ..  |||  | . .                . ......| ..| |..|||  .|.||||||  |.|
HLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHN

VLLKP-CTGPAGYEAKVADYGTAKVVQAE-NIGTVMPGNVAYAAPEAR---DPDQHSPAMDVYSYSVLLMEM
.|.   |   ..  .|..| ||.. ..      . ..|..|. |||..     .. | . ||.|. |.| ||
ILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMMSNAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEM
Kinase AqueK588.AA TKL-Unique 2-147 28 1.6e-20 69.22 In-house 47-221 (290) Show / Hide 
Range on Protein: 2-147
Range on HMM: 47-221/290
Sequence Identity: 28% (50 aa)

SIASRVR-HPKLVQFIGATK---VGNP--LILTELMSI-SLYKKLQ-----------ETELTNQQILSIAQDVALGLNYLHLFKPQPIIHRDVGSPNVLL
.. .. . || .|...|...   | .|   | .| ..  |||. |.           ...|..||....|.|.|.|..|||  .|  |||||  |.|.|.
NWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLV

KPCTGPAGYEAKVADYGTAKVVQAENIGTVM----------PGNVAYAAPEARDP--DQHSPAMDVYSYSVLLMEM
      | . .|..| |..|.   .| .|.            |.  ..|||      .| |   ||||... | |.
DNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQYSEKSDVYSFGIVLWEI
Kinase AqueK588.AA CZAK 2-153 30 2.2e-20 70.87 In-house 52-221 (279) Show / Hide 
Range on Protein: 2-153
Range on HMM: 52-221/279
Sequence Identity: 30% (53 aa)

SIASRVRHPKLVQFIGATKVGN---PLILTELMS-ISLYKKLQETELTNQQ----ILSIAQDVALGLNYLHL-FKPQPIIHRDVGSPNVLLKPCTG----
|| |  .||  |||.||   ..     | .| |   || . | .     .|     ...| |.| | ||||  .|| ||.|||  | |.||         
SIMSKLCHPNCVQFLGACSEDGPNHHCIVMEWMGGGSLRRLLTDHYFYHKQNPHLQWNMAIDIARGMNYLHDNWKPNPILHRDLSSRNILLDHSYTPKNP

----PAGYEAKVADYGTA--KVVQAENIGTVMPGNVAYAAPEARDPDQHSPAMDVYSYSVLLMEMTLCSQP
         .|..|.|    .  |.      | | ... |||    .  ..  ||||.  .| ..  | ||
VVSSRQDIICKINDFGLSREMMEQPFEMTQTM-GCLCWMAPECFKGENYTEKVDVYSFGMILWCIITCDQP
Kinase AqueK588.AA TK 8-197 13 1.5e-18 58.12 In-house 101-486 (486) Show / Hide 
Range on Protein: 8-197
Range on HMM: 101-486/486
Sequence Identity: 13% (51 aa)

RHPKLVQFIG-ATKVGN------------PLILTELMSI-----SLYKKLQETE----------------------------------------------
.|| .|...|  |....            ..|..|.|.      || . |..                                                
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LTNQQILSIAQDVALGLNYLHLFKP---QPIIHRDVGSPNVLLKPCTG------PAGYEAKVADYG---
                               || .| | .....| |. |||  .    | ..|||.   |.|.             |. .|.||.|   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----TAKVVQAENIGTVMPGN---------------------------VAYAAPEARD---------PDQHSPAMDVYSYSVLLMEMT-LC-SQPE--M
      |. .. .   ... .                            . . |||. .            .... ||.|. ||. |.  ..  ..   |
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

TT---------------------------------AEREVQSGSVSW------------SDIKSLIQRGLNANPRTRPTMAQVIDSL
.                                   ...   .  .|             ..  |.|.  ...|. |||..|. . |
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase AqueK588.AA TK-Unique 8-147 20 1.4e-13 43.33 In-house 62-232 (294) Show / Hide 
Range on Protein: 8-147
Range on HMM: 62-232/294
Sequence Identity: 20% (36 aa)

RHPKLVQFIGATK-VG-NPLILTELMSIS-----LYKKLQE-----------------------TELTNQQILSIAQDVALGLNYLHLFKPQPIIHRDVG
.|| .||..|..   . ...|. | .. .     | .. ..                       .... .. ...| ..| |..||.   .. |.|||. 
DHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQ-RKKIVHRDLC

SPNVLLKPCTGPAGYEAKVADYGTAKVVQA----ENIGTVMPGNVAYAAPEA-R--DPDQHSPAMDVYSYSVLLMEM
. ||||       ....|..|.| |. |..    .....  .  ... |||. .  .   |..  ||.|. ||. |.
ARNVLLTE-----DKVCKICDFGMARDVYTNGVYSMMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEI
Kinase AqueK588.AA HH498 47-147 38 2.7e-13 38.13 In-house 121-219 (284) Show / Hide 
Range on Protein: 47-147
Range on HMM: 121-219/284
Sequence Identity: 38% (40 aa)

QQILSIAQDVALGLNYLHLFKPQPIIHRDVGSPNVLLKPCTGPAGYEAKVADYGTAKVVQA---ENIGTVMPGNVAYAAPEARD-PDQHSPAMDVYSYSV
| .. |. ||| | ||||   ..||||||  | |.|.      .   |.|||.|    |.    .|. |  |||  . |||      . |   ||.||  
QSKMTISVDVAHGMNYLHNSLKHPIIHRDLNSHNILIH-----EDGHAVVADFGESRFVCDMHDDNM-TKQPGNLRWMAPEVFSQCQKYSIKVDVFSYAM

LLMEM
 . ||
CIWEM
Kinase AqueK588.AA LRRK 34-144 28 3.4e-13 43.0 In-house 141-272 (351) Show / Hide 
Range on Protein: 34-144
Range on HMM: 141-272/351
Sequence Identity: 28% (38 aa)

SLYKKLQETE----------LTNQQILSIAQDVALGLNYLHLFKPQPIIHRDVGSPNVLLKPCTGP-------AGYEAKVADYGTAK--VVQAENIGTVM
.||. |....          .. . .| || ..| |..||| ..| ||||||  |||.||.  . .       | . ||.||.|.     .  . .   .
DLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNP-PIIHRDLKSPNILLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGC

PGNVAYAAPEARDPD---QHSPAMDVYSYSVLL
 ||  . ||| .  .   . .   |.||. ..|
VGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMIL
Kinase AqueK588.AA Dicty4-Unclassified 49-147 30 5.8e-13 40.69 In-house 111-201 (263) Show / Hide 
Range on Protein: 49-147
Range on HMM: 111-201/263
Sequence Identity: 30% (30 aa)

ILSIAQDVALGLNYLHLFKPQPIIHRDVGSPNVLLKPCTGPAGYEAKVADYGTAKVVQAENIGTVMPGNVAYAAPEARDPDQHSPAMDVYSYSVLLMEM
|. .| |.| |. .||      .||||. | |.|.        . .|.|| | . |.      |   | ..  .||         . ||||| ..| |.
IIKYAFDIAQGMQHLHTRN---FIHRDIKSSNILMD-----KHFNIKIADFGISRVIDFNFNMTTIAGTPKWESPECLMHESYNQKSDVYSYAMMLYEL
Kinase AqueK588.AA Pkinase 6-197 18 1.4e-11 42.0 Pfam 56-293 (293) Show / Hide 
Range on Protein: 6-197
Range on HMM: 56-293/293
Sequence Identity: 18% (45 aa)

RVRHPKLVQFIGATK-VGNPLILTELMSI-----SLYKKLQ---ETEL--TNQQILSIAQDVALGLNYLHLFKPQPIIHRDVGSPNVLLK-PCTGPAGYE
|..||  |.....    ... . .|..       .|.  ..   .. .  . ... ...  .. ||.|.|      |||||. . |.|..  .. .|   
RLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDA--C

AKVADYGTAKVVQAENIGTVMPGNVA---YAAPEA-RDPDQHSPAMDVYSYSVLLMEMTL-------C------SQPEMTTAEREVQSGSVSW-------
 |..| | ||... .  .. | . .    |.|||  |.   ..|. |..|. ..| || .       .      .| .|    .. .  . ..       
VKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISY

----------------SDIKSLIQRGLNANPRTRPTMAQVIDS--L
                .. |..| . |. .|  ||| .|.  .  .
FFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase AqueK588.AA S_TKc 1-200 16 1.6e-11 -7.85 SMART 19-231 (231) Show / Hide 
Range on Protein: 1-200
Range on HMM: 19-231/231
Sequence Identity: 16% (39 aa)

MSIA---------------------SRVRHPKLVQFIGATKVGNPLILTELMSI---SLYKKLQETE-------LTNQQILSIAQDVALGLNYLHLFKPQ
  .                      .. .|| .|.....   ..  . .|...    .|.. ...         ..  .. .... ....|.|.|  .  
RHKKTGRIVAIKIIKEHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHG--

PIIHRDVGSPNVLLKPCTGPAGYEAKVADYGTAKVVQAENIGTVMPGNVAYAAPEARDPDQHSP-AMDVYSYSVLLMEMTLCSQPEMTTAEREVQSGSVS
 |||||.   |.||         . |..| | |...      | . |   | |||     .... . |..|  ..| ||     |   . ..  .     
-IIHRDLKPENILLDE-------HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP-QMQMMFKKIG--

WSDIKSLIQRGLNANPRTRPTMAQVID------SLKRM
 .. |..|.. |. .|. |||  ..        .   .
SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase AqueK588.AA Dicty4 5-75 32 1.8e-11 34.67 In-house 53-139 (277) Show / Hide 
Range on Protein: 5-75
Range on HMM: 53-139/277
Sequence Identity: 32% (29 aa)

SRVRHPKLVQFIGA-T----KVGNPLILTELM-SISLYKKLQE------TELTNQ--QILS---IAQDVALGLNYLHLFKPQPIIHRD
.  ||| ...| || |    . | ..| ||.| . .||. |         . . .   |..   .| |.|.|.|.||   |  |||||
CKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPV-IIHRD
Kinase AqueK588.AA TyrKc 1-197 15 8.1e-11 -47.73 SMART 1-280 (280) Show / Hide 
Range on Protein: 1-197
Range on HMM: 1-280/280
Sequence Identity: 15% (45 aa)

MSIA----------------------------------------SRV--RHPKLVQFIGATKV--------GNPLILTELMS-ISLYKKLQETE--LTNQ
 .                                          ...  .|| .|...|.           . ..|..|.|.  .| . |....  |...
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMK

QILSIAQDVALGLNYLHLFKPQPIIHRDVGSPNVLLKPCTGPAGYEAKVADYGTAKVVQAE-------NIGTV-----MP--GNVAYAAPEARDPDQHSP
. ||.. ..| | .|||     ..||||    |.|..         .|..| | .. .  .          ..           .   |||. .    ..
DLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENH-----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTT

AMDVYSYSVLLMEM-TLCSQPE-------MTTAE--REVQSG------SV--------SWSDIKSLIQRGLNANPRTRPTMAQVIDSL
. ||.|. |.. |. |.. ||        |. .|  . |..|                  ... .....  ...|  |||...... .
KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase AqueK588.AA Pkinase_Tyr 8-147 24 1.4e-10 36.5 Pfam 62-207 (270) Show / Hide 
Range on Protein: 8-147
Range on HMM: 62-207/270
Sequence Identity: 24% (37 aa)

RHPKLVQFIGATK-VGNP---LILTELMSI-SLYKKLQET-----ELTNQQILSIAQDVALGLNYLHLFKPQPIIHRDVGSPNVLLKPCTGPAGYEAKVA
.||..|...|.    | |   .| .|.|   .|.. |..       || ...|......| |..||.  .   .||||.   |.|..      .  .|..
HHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTE-----NNVVKIC

DYGTAKVVQAENIG-TVMP---GNVAYAAPEARDPDQHSPAMDVYSYSVLLMEM
| | |. .. .    ..       .   |||.      . . ||.|. ||. |.
DFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEI
Kinase AqueK588.AA MLK 172-197 30 5.3e-07 20.46 In-house 266-291 (291) Show / Hide 
Range on Protein: 172-197
Range on HMM: 266-291/291
Sequence Identity: 30% (8 aa)

IKSLIQRGLNANPRTRPTMAQVIDSL
.|.|...  |..|. ||...|..  |
WKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase AqueK588.AA HH498 172-197 30 1.7e-05 12.97 In-house 259-284 (284) Show / Hide 
Range on Protein: 172-197
Range on HMM: 259-284/284
Sequence Identity: 30% (8 aa)

IKSLIQRGLNANPRTRPTMAQVIDSL
. .|||.. ...|  ||. .|..  |
WSNLIQMCWHPCPENRPDFDQIVTIL
Kinase AqueK588.AA Dicty4 172-199 30 4.4e-05 13.09 In-house 248-277 (277) Show / Hide 
Range on Protein: 172-199
Range on HMM: 248-277/277
Sequence Identity: 30% (9 aa)

IKSLIQRGLNANPRTRPTMAQVIDS--LKR
.|.|||. .. .|  ||.....|    |  
WKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase AqueK588.AA Dicty4-Unclassified 172-197 42 7.2e-05 12.57 In-house 238-263 (263) Show / Hide 
Range on Protein: 172-197
Range on HMM: 238-263/263
Sequence Identity: 42% (11 aa)

IKSLIQRGLNANPRTRPTMAQVIDSL
.|.||   .   |. |||| |.|. |
WKKLIKWCWHNDPNKRPTMNQIIQYL
Kinase AqueK588.AA LRRK 162-199 23 0.000173 11.78 In-house 314-351 (351) Show / Hide 
Range on Protein: 162-199
Range on HMM: 314-351/351
Sequence Identity: 23% (9 aa)

VQSGSVSWSDIKSLIQRGLNANPRTRPTMAQVIDSLKR
.. . . | . ..|||   ...|. ||.. |... |. 
YCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase AqueK588.AA TKL-Unique 171-197 29 0.000528 10.22 In-house 264-290 (290) Show / Hide 
Range on Protein: 171-197
Range on HMM: 264-290/290
Sequence Identity: 29% (8 aa)

DIKSLIQRGLNANPRTRPTMAQVIDSL
... |||.. . .|  ||.  ..| .|
EYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase AqueK588.AA TK-Unique 163-197 20 0.037418 3.37 In-house 260-294 (294) Show / Hide 
Range on Protein: 163-197
Range on HMM: 260-294/294
Sequence Identity: 20% (7 aa)

QSGSVSWSDIKSLIQRGLNANPRTRPTMAQVIDSL
|  ...  .. .|... .. .|  ||. .|... |
QPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase AqueK588.AA CZAK 169-197 34 0.046479 3.46 In-house 251-279 (279) Show / Hide 
Range on Protein: 169-197
Range on HMM: 251-279/279
Sequence Identity: 34% (10 aa)

WSDIKSLIQRGLNANPRTRPTMAQVIDSL
| ..  || .  | ||  ||.  |... |
WKNLGELIEMCWNKNPDERPSFKQILQHL
Kinase AqueK588.AA Pkinase_Tyr 169-197 24 0.671292 3.67 Pfam 242-270 (270) Show / Hide 
Range on Protein: 169-197
Range on HMM: 242-270/270
Sequence Identity: 24% (7 aa)

WSDIKSLIQRGLNANPRTRPTMAQVIDSL
. .| .|...  ...|  |||.....  |
PDEIYDLMKQCWHYDPEDRPTFSEIHEQL