Gene AqueK460 (A.queenslandica)

AqueK460

Species: A.queenslandica
Alias: AqueK460
External Links:
Annotation:

Classification

Group: TK
Family: TK-Unique

Sequence

Name Sequence Type Origin Length Description Download
AqueK460.AA Protein None 1008 None Fasta, JSON
AqueK460.kin_dom Protein Kinase Domain None 383 None Fasta, JSON

Protein domain

Protein domains of AqueK460.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
IG AqueK460.AA IG 201-323 11 2.6e-05 24.87 SMART 1-58 (58) Show / Hide 
Range on Protein: 201-323
Range on HMM: 1-58/58
Sequence Identity: 11% (15 aa)

SSPMYVEAGTELLLDCVFSSTAHFNLYIGWSLSNRDLFLIAEDPLCSNDCYVDKRGTAMENKAKRIRAYQARDQLACIFLSYKVHTYLYIEDVKLSDE--
.. ..| .|  . | | .|       .| |.                                                        | | .|...|.  
PP-VTVKEGETVTLTC-VS-------QIWWY--------------------------------------------------------LTI-NVQPEDSQQ

-GNYTCYYHYTPSWTSQKG--FKTVNII
 |.|.|  .    . ....  . |. . 
HGTYYCQAT----HGQYWSIQGTTLTVQ
IG AqueK460.AA IG 344-454 9 0.019302 12.14 SMART 1-58 (58) Show / Hide 
Range on Protein: 344-454
Range on HMM: 1-58/58
Sequence Identity: 9% (11 aa)

PSFISSTINDTISLSCTVRVGLGASVYWIDPNNTVIDEYDSSTMESSEFSVYVESRNETTDDQYQIIAHRTLIISDFIDSLDDVV-GVYKCVVSDPGYQE
|. ..    .|..|.| |      ...|                                           |.| .   .      |.| |...      
PP-VTVKEGETVTLTC-VS-----QIWWY------------------------------------------LTI-NVQPEDSQ-QHGTYYCQAT-----H

KSVYE--EYSVILT
....   .  .. .
GQYWSIQGTTLTVQ
Pkinase_Tyr AqueK460.AA Pkinase_Tyr 596-978 25 5.1e-112 380.01 Pfam 1-270 (270) Show / Hide 
Range on Protein: 596-978
Range on HMM: 1-270/270
Sequence Identity: 25% (102 aa)

LMFIDKLGSGLFGQVWKAYIL----GSESIVAVKTTKDQCSLRD--EENLKEELQIMKKIQPHANVINLLGFCT-SDGP--VSIIMEYALYGNLHDFLKY
. |. |||.| ||.|.|..      . .  ||||. |.... ..   | . .|..|||..  | |...|.| ||  ..|  . |.|||. .|.|.|.|. 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

CRPPLFPSRGGGPLMYNWINHHTAISSPHSSYSSSSCSSPSSSTTPFLDKSSHVPLSAQVSNSTTHTYLQFSSDLTTPPPSLHQFSLEDPSAGRSLFEAL
 |                                                                                                  
HR--------------------------------------------------------------------------------------------------

SHQVAGLVPSAHSACPLSHDYINIPGRIRNGDFLNFAFQIASGLDHLKRMNLIHCDLAARNILVSKEQVLKISDFGLAKEVSDDKSYY-RRNPRDRIPIK
                      . ....   | |....|||.|...| ..|.|| ||||||.||... | ||.|||||. .  ...|| |     ..|||
----------------------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI-YNDDYYYRKRGGGKLPIK

WTSPEALETWVYSHKSDIWSYGVVLWEIATYGDSP-YREVNTSGIWDNMISHL-KSGNRLEQPLNCPDIFYNIMCMCWELDPERRPDATDVIKLL
|..||.. . ....|||.||.||..||| |||..| | ..  .     .. .. ..|.|...| ||||  |..|..||. |||.||  ....  |
WMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEE----VYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
TyrKc AqueK460.AA TyrKc 596-978 25 7.6e-109 368.82 SMART 1-280 (280) Show / Hide 
Range on Protein: 596-978
Range on HMM: 1-280/280
Sequence Identity: 25% (107 aa)

LMFIDKLGSGLFGQVWKAYILGSESIVAVKTTKDQCSLRDEENLKEELQIMKKI-QPHANVINLLGFCTSD-------GPVSIIMEYALYGNLHDFLKYC
. ...|||.| ||.|.|.        ||||. |. .    .| . .|..||.|.   | |...|.| ||..       .|. |.|||. .|.|.|.|...
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

RPPLFPSRGGGPLMYNWINHHTAISSPHSSYSSSSCSSPSSSTTPFLDKSSHVPLSAQVSNSTTHTYLQFSSDLTTPPPSLHQFSLEDPSAGRSLFEALS
||                                                                                                  
RPK-------------------------------------------------------------------------------------------------

HQVAGLVPSAHSACPLSHDYINIPGRIRNGDFLNFAFQIASGLDHLKRMNLIHCDLAARNILVSKEQVLKISDFGLAKEVSDD------KSYYRRN--PR
                          . . |.|.|..|||.| ..| ..|.|| ||||||.||..... |||||||.... ||      |.|||      
--------------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKG

DR--IPIKWTSPEALETWVYSHKSDIWSYGVVLWEIATYGDSPYRE-----VNTSGIWDNMISHLKSGNRLEQPLN--------CPDIFYNIMCMCWELD
 .  .||.|..||.. . ....|||.||.||..||| |||..|| .     ..    .. .| ..|.|.|..|| |        |||  |.|| .||. |
GKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMS----NQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHED

PERRPDATDVIKLL
|| ||  .......
PEDRPTFSEIHECF
Kinase AqueK460.AA TK 596-978 17 3.6e-98 329.71 In-house 1-486 (486) Show / Hide 
Range on Protein: 596-978
Range on HMM: 1-486/486
Sequence Identity: 17% (107 aa)

LMFIDKLGSGLFG---QVWKAYILGSE-------------------------SIVAVKTTKDQCSLRDEENLK-------------EELQIMKKIQ----
. ...|||.| ||   .|.|.   |                             ||||. |. ..  .|| .              ||...||. .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

PHANVINLLGFCTSD------------GPVSIIMEYALYGN----LHDFLKYCRPPLFP------------------SRGGGPLMYNWINHHTAISSPHS
 | |...|.| || .            .|. |.|||. .|.    |.|.|. |||. ..                  ..                     
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHC---------------------

SYSSSSCSSPSSSTTPFLDKSSHVPLSAQVSNSTTHTYLQFSSDLTTPPPSLHQFSLEDPSAGRSLFEALSHQVAGLVPSAHSACPLSHDYIN-------
                                                                                          . .       
------------------------------------------------------------------------------------------M-KGDITYSH

-------------------IPGRIRNGDFLN-------------------FAFQIASGLDHLKRM------NLIHCDLAARNILVSKEQV----------
                   .|  ..  |.|.                   ...|||.|. .| ..      |..| ||||||.||... |          
ESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGP

-LKISDFG--------LAKEVSDDKSYYRRN-----------------------PRDRIPIKWTSPEALETWV---------YSHKSDIWSYGVVLWEIA
  ||.|||        ||... .|. |||..                       .....||.|..||.|.. |         ...|||.||.||..||| 
VCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIF

TYG-DSPYREVNTSGIWD-----NMISHLKSG--------------NRLEQPLNCP--------------DIFYNIMCMCWELDPERRPDATDVIKLL
|||   .| ... .. |       .. .|..|              .|..|| .||              ...| .|..||..|||.||. ... . |
TYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase AqueK460.AA TK-Unique 596-978 25 1.5e-91 310.48 In-house 1-294 (294) Show / Hide 
Range on Protein: 596-978
Range on HMM: 1-294/294
Sequence Identity: 25% (104 aa)

LMFIDKLGSGLFGQVWKAYILGSE------SIVAVKTTKDQCSLRDEENLKEELQIMKKIQPHANVINLLGFCTSDG-PVSIIMEYALYGNLHDFLKYCR
| . |..|.| |||||.. . |        ..||||. ||  .. |. ... |.|.||.. .| |....|| ||... |. |||||. .||| ..|..||
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

PPLFPS------RGGGPLMYNWINHHTAISSPHSSYSSSSCSSPSSSTTPFLDKSSHVPLSAQVSNSTTHTYLQFSSDLTTPPPSLHQFSLEDPSAGRSL
|. ...      .                                                                                       
PAMRQHQTYGNLK---------------------------------------------------------------------------------------

FEALSHQVAGLVPSAHSACPLSHDYINIPGRIRNGDFLNFAFQIASGLDHLKR--MNLIHCDLAARNILVSKEQVLKISDFGLAKEVSDDKSYYRRNPRD
                   . ..  .. .  |  .|...||.|||.|. .|..  .. .| ||.|||.|..   |.||.|||.|..|.... | .   . 
-----------------FDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQG

RIPIKWTSPEALE--TWVY-SHKSDIWSYGVVLWEIATYGDSPYREVNTSGIWDNMISHLKSGNRLEQPLNC-PDIFYNIMCMCWELDPERRPDATDVIK
||||.| .||.|   . .| . |||.||.||..|||.|.|  ||...     |.... ... | |..|| .| .. .||.|  || ..|| ||. .....
RIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGM----PWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKH

LL
 |
RL
Kinase AqueK460.AA KIN6 805-978 37 8.3e-65 213.04 In-house 127-305 (305) Show / Hide 
Range on Protein: 805-978
Range on HMM: 127-305/305
Sequence Identity: 37% (69 aa)

HDYINIP-----GRIRNGDFLNFAFQIASGLDHLKRMNLIHCDLAARNILVSKEQ---VLKISDFGLAKEVSDDKSYYRRNPRDR-IPIKWTSPEALETW
|. ....      .||  |...||.||. |.  |   |.|| ||||||.|| .       |||||||. .  .|.. |     .|  |||| .||.|.. 
HCPDENSRYDDMMCIRHKDLYMFAWQICDGMEYLHSKNCIHRDLAARNVLVTEGCRMKTCKISDFGLCRYPYMDQFQYTSKG-GRYLPIKWMAPECLKHY

VYSHKSDIWSYGVVLWEIATYGDSPYREVN-TSGIWDNMISHLKSGNRLEQPLNCPDIFYNIMCMCWELDPERRPDATDVIKLL
 .| |||.||.||...|. . ||.|| |.  .      || |..|| |...|..||. .|.||  ||  .|..||. ... ...
EFSYKSDVWSFGVLMFEMFSLGDVPYPEMQRP----TEMIEHHRSGRRPKHPKWCPEEIYDIMQSCWQEKPDDRPEFNEMRMQF
Kinase AqueK460.AA UTK 820-978 35 3.8e-59 201.0 In-house 121-296 (296) Show / Hide 
Range on Protein: 820-978
Range on HMM: 121-296/296
Sequence Identity: 35% (64 aa)

LNFAFQIASGLDHLKRMNLIHCDLAARNILVSKE-------QVLKISDFG---LAKEVSD--------DKSYYRRNPRDRIPIKWTSPEALETW-VYSHK
| .| .||.|. .| .....|.||||||.|| .        .| ||.|||   ....|..        .  ||.....||.||.|..||||     ...|
LCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDRWPIRWMAPEALTHHTRFTTK

SDIWSYGVVLWEIATYGDSPYREVNTSGIWDNMISHLKSG-NRLEQPLNCPDIFYNIMCMCWELDPERRPDATDVIKLL
||.||.|||.||| |.|  || . ..  .| .    .. |  |...|  ||.  |..|  ||. ||..|||. |. . .
SDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQV---CNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase AqueK460.AA FGFR 818-978 44 7.5e-59 199.21 In-house 137-293 (293) Show / Hide 
Range on Protein: 818-978
Range on HMM: 137-293/293
Sequence Identity: 44% (72 aa)

DFLNFAFQIASGLDHLKRMNLIHCDLAARNILVSKEQVLKISDFGLAKEVSDDKSYYRRNPRDRIPIKWTSPEALETWVYSHKSDIWSYGVVLWEIATYG
|   .|.|.| | . |     || ||||||.||. . |.||.|||||  .  .  ||| .   | ||||  ||||   || |.||.||||| |||| |||
DLVSCAYQVARGMEYLASRKCIHRDLAARNVLVTDDYVMKICDFGLARDI-HCIDYYRKTTNGRLPIKWMAPEALFDRVYTHQSDVWSYGVLLWEIMTYG

DSPYREVNTSGI-WDNMISHLKSGNRLEQPLNCPDIFYNIMCMCWELDPERRPDATDVIKLL
..||  .         . . ||.| |.| | ||.   | .|| ||   |. ||  . ..  |
GQPYPHI----PSVEELYKYLKEGHRMEKPHNCSQEIYHMMCQCWHFKPCQRPTFKQLVEYL
Kinase AqueK460.AA Fer 820-979 34 1.5e-57 194.54 In-house 114-283 (283) Show / Hide 
Range on Protein: 820-979
Range on HMM: 114-283/283
Sequence Identity: 34% (59 aa)

LNFAFQIASGLDHLKRMNLIHCDLAARNILVSKEQVLK---ISDFGLAKEVSDDKSYYRRN-PRDRIPIKWTSPEALETWVYSHKSDIWSYGVVLWEIAT
.....|.|.|...|  .| || |.||||.|..|..| |   |||||.... ||... |.   . ...||.|..||...| .||.|.|.||.||..||| |
IRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGMSRQCSDYGYDYKMKEKACKVPIRWLAPETWQTGIYSPKTDVWSFGVMCWEIFT

YGDSPYRE----VNTSGIWDNMISH-LKSGNRLEQPLNCPDIFYNIMC-MCWELDPERRPDATDVIKLLS
 |. || .    .    . . ..    |.|...  |...|. ...||. .||. ||| || ...... | 
NGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK
Kinase AqueK460.AA Src 820-969 43 2.2e-55 186.57 In-house 100-246 (255) Show / Hide 
Range on Protein: 820-969
Range on HMM: 100-246/255
Sequence Identity: 43% (65 aa)

LNFAFQIASGLDHLKRMNLIHCDLAARNILVSKEQVLKISDFGLAKEVSDDKSYYRRNPRDRIPIKWTSPEALETWVYSHKSDIWSYGVVLWEIATYGDS
. .| |.|.| . | .||.|| ||||||.||... | |. |||||. . .|.  |      ..||||| |||.   ... ||| ||.|. |.|| |||  
IDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGRV

PYREVNTSGIWDNMISHLKSGNRLEQPLNCPDIFYN-IMCMCWELDPERRP
||.  .        . ... | |. .| |||| .|. ||..||. |||.||
PYPGMTNHEV----LQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRP
Kinase AqueK460.AA VEGFR 818-978 42 1.8e-51 177.33 In-house 174-332 (332) Show / Hide 
Range on Protein: 818-978
Range on HMM: 174-332/332
Sequence Identity: 42% (69 aa)

DFLNFAFQIASGLDHLKRMNLIHCDLAARNILVSKEQVLKISDFGLAKE-VSDDKSYYRRNPRDRIPIKWTSPEALETWVYSHKSDIWSYGVVLWEIATY
| ....||.| | . |   . || ||||||||..   |.||.|||||.    .|  | |.  . | |||| .||..   ||. .||.|||||.|||| . 
DLICYSFQVARGMEFLASRKCIHRDLAARNILLCENNVVKICDFGLARHGIYKDPDYVRKGDQGRLPIKWMAPESIFDKVYTTYSDVWSYGVFLWEIFSL

GDSPYREVNTSGIWDNMISHLKSGNRLEQPLNCPDIFYNIMCMCWELDPERRPDATDVIKLL
| |||  |    | .  .. ||.|.|.. |  |.   | ||  ||  .|| ||   .  . |
GGSPYPGVQ---IDEEFCNRLKDGYRMRAPDYCTPEIYHIMLDCWHKEPEERPHFSELVEHL
Kinase AqueK460.AA Abl 820-978 42 2e-49 162.81 In-house 100-252 (252) Show / Hide 
Range on Protein: 820-978
Range on HMM: 100-252/252
Sequence Identity: 42% (67 aa)

LNFAFQIASGLDHLKRMNLIHCDLAARNILVSKEQVLKISDFGLAKEVSDDKSYYRRNPRDRIPIKWTSPEALETWVYSHKSDIWSYGVVLWEIATYGDS
|  | |||||.. | . . || |||||| ||. ....|. |||||. . ||   |      . ||||| ||.|    .| |||.| .||.|||||||| |
LYMATQIASGMSYLEKRHFIHRDLAARNCLVGEHHIVKVADFGLARMMKDD--TYTAHAGAKFPIKWTAPESLAYNKFSSKSDVWAFGVLLWEIATYGMS

PYREVNTSGIWDNMISHLKSGNRLEQPLNCPDIFYNIMCMCWELDPERRPDATDVIKLL
||  .. | ...     |  | |.|.|  ||.  |..|  ||. ..  ||  ... . .
PYPGIDLSHVYH----KLEKGYRMERPEGCPPKVYELMRQCWQWSHTDRPSFKEIHHAM
Kinase AqueK460.AA RTKB 811-978 35 1.3e-48 162.01 In-house 103-264 (264) Show / Hide 
Range on Protein: 811-978
Range on HMM: 103-264/264
Sequence Identity: 35% (60 aa)

PGRIRNGDFLNFAFQIASGLDHLKRMNLIHCDLAARNILVSKEQVLKISDFGLAKEVSDDKSYYRRNPRDRIPIKWTSPEALETWVYSHKS-DIWSYGVV
|. .. .  . |. |||.|  .| . | || ||.|||.||...   ||.|||.| |. ...    . . .| ||||  || ..   |. || |.||.|| 
PQSLKQAQLVDFCHQIACGMAFLHQHNVIHRDLCARNVLVDQQLHCKICDFGMAREIDHECY---ETTCTRLPIKWMAPESWAHRIYTTKSGDVWSFGVT

LWEIATYGDSPYREVNTSGIWDNMISHLKSGNRLEQPLNCPDIFYNIMCMCWELDPERRPDATDVIKLL
 ||| . |  || .  .      . ..| || ||..|   |  .. || ||| .... ||| . .....
MWEIFSLGGTPYQQYRNG----DIFYWLESGHRLPKPRQMPQAADHIMQMCWQMEAQHRPDFDELVDAF
Kinase AqueK460.AA FGFR 596-690 44 5.5e-26 85.52 In-house 1-102 (293) Show / Hide 
Range on Protein: 596-690
Range on HMM: 1-102/293
Sequence Identity: 44% (45 aa)

LMFIDKLGSGLFGQVWKAYIL---GS----ESIVAVKTTKDQCSLRDEENLKEELQIMKKIQPHANVINLLGFCTSDGPVSIIMEYALYGNLHDFLKYCR
|     || | |||||.|       .    |..||||  |.  . .|   |  |. .|| |  | |.||||| || .||  .| ||.  ||| |||.  |
LTLGKMLGEGCFGQVWMAEAKGIDCDRPEKEITVAVKMLKMNHTDKDLSDLVSEMEMMKMIGKHKNIINLLGCCTQEGPLYVIVEYCHHGNLRDFLRARR

PP
||
PP
Kinase AqueK460.AA Src 596-685 38 6.7e-20 64.26 In-house 1-86 (255) Show / Hide 
Range on Protein: 596-685
Range on HMM: 1-86/255
Sequence Identity: 38% (35 aa)

LMFIDKLGSGLFGQVWKAYILGSESIVAVKTTKDQCSLRDEENLKEELQIMKKIQPHANVINLLGFCTSDGPVSIIMEYALYGNLHDFLK
. ...|||.| || ||..|  |.   ||||| |      . | . .| ||||| . | ....|.  |. . |. |. ||   |.| |.||
IKLCRKLGQGQFGEVWMGYWNGNTK-VAVKTLKPGT--MSPEAFLQEAQIMKKLR-HEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLK
Kinase AqueK460.AA Pkinase 821-978 20 2.3e-19 69.55 Pfam 112-293 (293) Show / Hide 
Range on Protein: 821-978
Range on HMM: 112-293/293
Sequence Identity: 20% (39 aa)

NFAFQIASGLDHLKRMNLIHCDLAARNILVSKEQVL----KISDFGLAKEVSDDKSYYRRNPRDRIPIKWTSPEALE-TWVYSHKSDIWSYGVVLWEIAT
... ||..||... .|. ||.||   |||.... ..    ||.|||||| ..   ..   . .    . . .|| .     |..|.|.||.|..|.| ..
FYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTF-CGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLC

YGDSPYREVNTSGIWDNMISHLKSGNRLEQPLNCP-----------------------DIFYNIMCMCWELDPERRPDATDVIKL--L
 |  |... ...   ....  ..   . . . ..|                       . .  ... |...||..|| |... .   .
-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase AqueK460.AA Abl 596-687 41 5.7e-19 59.46 In-house 1-89 (252) Show / Hide 
Range on Protein: 596-687
Range on HMM: 1-89/252
Sequence Identity: 41% (38 aa)

LMFIDKLGSGLFGQVWKAYILGSESIVAVKTTKDQCSLRDEENLKEELQIMKKIQPHANVINLLGFCTSDGPVSIIMEYALYGNLHDFLKYC
.|  .||| | .|.|....    . .||||| |..  .. .| || |  |||... | |.. ||| || . |  || |.  |||| |.|. |
IMMKHKLGGGQYGEVYEGVWKRHDCTVAVKTLKEDT-MEVHEFLK-EAAIMKEMK-HPNLVQLLGVCTREPPFYIITEFMCYGNLLDYLREC
Kinase AqueK460.AA RTKB 596-690 31 5.5e-18 57.25 In-house 1-99 (264) Show / Hide 
Range on Protein: 596-690
Range on HMM: 1-99/264
Sequence Identity: 31% (31 aa)

LMFIDKLGSGLFGQVWKAYILGSESI----VAVKTTKDQCSLRDEENLKEELQIMKKIQPHANVINLLGFCTSDGPVSIIMEYALYGNLHDFLKYCRPP
.    |||.| ||.|..|..  . .     .|.|. | . |...     .|. .|| . .| ||| ..| |  | |  .  |.. .||| |.|. || .
VWLGEKLGNGAFGEVFQAWVRNRHMNTEQSCAAKVLKPGASYEERQDFCSEMTVMKELGWHPNVIGIIGHCLQDEPYILLVELCELGNLRDYLRMCRAS
Kinase AqueK460.AA S_TKc 596-985 14 1.5e-16 62.2 SMART 1-231 (231) Show / Hide 
Range on Protein: 596-985
Range on HMM: 1-231/231
Sequence Identity: 14% (58 aa)

LMFIDKLGSGLFGQVWKAYILGSESIVAVKTTKDQCSLRDEENLKEELQIMKKIQPHANVINLLGFCTSDGPVSIIMEYALYGNLHDFLKYCRPPLFPSR
  ...|.|.| ||.|.|..  ..  |||.|  |                                                                   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------------------------------------------------------------

GGGPLMYNWINHHTAISSPHSSYSSSSCSSPSSSTTPFLDKSSHVPLSAQVSNSTTHTYLQFSSDLTTPPPSLHQFSLEDPSAGRSLFEALSHQ-VAGLV
                                                                              |.    ... .   |  .  | 
------------------------------------------------------------------------------EHIRREIQILKK-HHPNIVKLY

PSAH--------SACPL----SHDYINIPGR------IRNGDFLNFAFQIASGLDHLKRMNLIHCDLAARNILVSKEQVLKISDFGLAKEVSDDKSYYRR
 . .          |.      .|||   ||      .   .   .. ||...|... ... ||.||   |||...  ..||.|||||...         
DVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------

NPRDRIPIKWTSPEALETWVYSH-KSDIWSYGVVLWEIATYGDSPYREVNTSGIWDNMISHLKSGNRLEQPLNCPDIFYNIMCMCWELDPERRPDATDVI
         . .|| |    |.. |.|.|| |..|.| .. |  |..  .   .....                .. . .... |.. |||.|| | .. 
-TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC-GYPPFP--QMQMMFKKIG---------------SPEAKDFIRKCLQKDPEKRPTA-EAL

K--LLSRKPSLL
.  .. ..   .
QDEWDIKCHPWF
Kinase AqueK460.AA Pkinase 596-685 29 7.9e-16 57.05 Pfam 1-96 (293) Show / Hide 
Range on Protein: 596-685
Range on HMM: 1-96/293
Sequence Identity: 29% (29 aa)

LMFIDKLGSGLFGQVWKAYILGSESIVAVKTTKDQCSLRDEENLKE-----ELQIMKKIQPHANVINLLGFCTSDGPVSIIMEYALYG----NLHDFLK
. .. |.||| ||.|.|..  |.. |||||. | .   .... ...     |.||||... | |.. |........ . ..|||.  |     |.|...
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR--HEKSWKDQTHRRLSEIQIMKRLN-HPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIS
Kinase AqueK460.AA UTK 596-695 30 1.1e-15 50.11 In-house 1-112 (296) Show / Hide 
Range on Protein: 596-695
Range on HMM: 1-112/296
Sequence Identity: 30% (34 aa)

LMFIDKLGSGLFGQVWKAYIL-----GSESIVAVKTTK-DQCSLRDEE---NLKEELQ---IMKKIQPHANVINLLGFCTSDGPVSIIMEYALYGNLHDF
... ..||.| ||.| ||        . |..||||. . .  . ...|    . || .   .||. . | ||..|.| ||...|  |..||.  |.| ..
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LKYCRPPLFPSR
| ..|| ... .
LRRHRPTPPACP
Kinase AqueK460.AA Fer 596-685 32 2.4e-13 41.94 In-house 1-101 (283) Show / Hide 
Range on Protein: 596-685
Range on HMM: 1-101/283
Sequence Identity: 32% (33 aa)

LMFIDKLGSGLFGQVWKAY-----ILGSESIV---AVKTTKDQCSLRDEENLKEELQ---IMKK-IQPHANVINLLGFCTSDGPVSIIMEYALYGNLHDF
  ...|||.| || |.|.      ..|  . |   |||..|  |.. ..|..|| ..   ||..  . | ||. . |.|... |. |.||..  |.| ..
VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYD-HPNVVKFYGVCVDEQPIMIVMEFCNGGSLDSY

LK
||
LK
Kinase AqueK460.AA VEGFR 601-685 38 4e-13 46.03 In-house 6-98 (332) Show / Hide 
Range on Protein: 601-685
Range on HMM: 6-98/332
Sequence Identity: 38% (36 aa)

KLGSGLFGQVWKAY---ILGSES--IVAVKTTKDQCSLRDEENLKEELQIMKKIQPHANVINLLGFCT---SDGPVSIIMEYALYGNLHDFLK
 || | |||| .|    | ..|.  .||||  |          |  || ... |  | || |.|| ||     ||. .|.||  .||| ..|.
MLGRGAFGQVHEASAFGIRKMETCTTVAVKMLKEGATASEHRALMSELKMLIHIGHHLNVVNFLGCCTKNIQKGPLMVIVEYCCFGNLSNYLR