Gene AqueK397 (A.queenslandica)

AqueK397

Species: A.queenslandica
Alias: AqueK397
External Links:
Annotation:

Classification

Group: TK
Family: REF

Sequence

Name Sequence Type Origin Length Description Download
AqueK397.AA Protein None 972 None Fasta, JSON
AqueK397.kin_dom Protein Kinase Domain None 318 None Fasta, JSON

Protein domain

Protein domains of AqueK397.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
TyrKc AqueK397.AA TyrKc 479-796 34 1.7e-122 414.14 SMART 1-280 (280) Show / Hide 
Range on Protein: 479-796
Range on HMM: 1-280/280
Sequence Identity: 34% (120 aa)

VRKDQTLGSGCFGEVFKGFLQKNYVLTKRRLSHDHDLHSRRGSLPQETYPVAVKKLKSIADGKERSDFLKEIEVMKTV--SSTDSDLRRFVVNMLGCCSL
......||.|.||||.|| .                            ..||||.||. |    | ||..|...|. .  .         .|...|.|. 
ITLGKKLGEGAFGEVYKGTWK---------------------------IQVAVKMLKEDA----REDFMREARIMCKLGGHH------PNIVRLYGVCTQ

E-------EPMLLVVEFVENGDLLNYLRRMKRKAQGNNSTAPPAPYLEPLGSYSLLEPKSELDNEGFLTERNLLDFSRQIASGMEYLSSLGIIHRDLACR
.       ||...|.|....|||..|||. ..|                                  |. . ||.|. |||.|||||.| ..||||||.|
QGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK----------------------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAAR

NVLVGKEKNLKISDFGLSRVVLSD-------MVYTLTN--HGR--LPLRWMALESIFQREFTTSSDVWSYGVALWEICTMGAFPYAT-----MQEKELLK
|.|||...  ||||||||| . .|        .|. .   .|.  ||.||||.|.|. ..||| |||||.|| .|||.| |. ||       |  .|...
NCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIE

LLKKGYRLPKPQN--------CSQDMFEVMHQCWHPNPQGRPTFSNLHKLF
..|.|||.|.|.|        |...|...| |||| .|  |||||..|..|
YVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Pkinase_Tyr AqueK397.AA Pkinase_Tyr 479-796 35 6e-121 410.25 Pfam 1-270 (270) Show / Hide 
Range on Protein: 479-796
Range on HMM: 1-270/270
Sequence Identity: 35% (115 aa)

VRKDQTLGSGCFGEVFKGFLQKNYVLTKRRLSHDHDLHSRRGSLPQETYPVAVKKLKSIADGKE--RSDFLKEIEVMKTV-SSTDSDLRRFVVNMLGCCS
......||.|.||||.|| .                      .  ....|||||.||  |. ..  | ||..|...||.  .         .|...|.|.
ITFGKKLGEGAFGEVYKGTWKG--------------------DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHH------PNIVRLYGVCT

-LEEP--MLLVVEFVENGDLLNYLRRMKRKAQGNNSTAPPAPYLEPLGSYSLLEPKSELDNEGFLTERNLLDFSRQIASGMEYLSSLGIIHRDLACRNVL
  .||  ...|.|....||||.|||. .                               .... ||   ||....|||.|||||.| ..||||||.||.|
DQGEPNQIYIVMEYMPHGDLLDYLRKHR-------------------------------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCL

VGKEKNLKISDFGLSRVVLSDMVY-TLTNHGRLPLRWMALESIFQREFTTSSDVWSYGVALWEICTMGAFP-YATMQEKELLKLL-KKGYRLPKPQNCSQ
|....  ||.||||.| . .|  | . . .|.|| .|||.|.|. ..||| |||||.|| .|||.| |. | |. |   |..... ..|||.|.|.||..
VTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPD

DMFEVMHQCWHPNPQGRPTFSNLHKLF
.. ..| ||||..|. ||||| .|  .
EIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase AqueK397.AA TK 479-796 24 6.5e-101 339.08 In-house 1-486 (486) Show / Hide 
Range on Protein: 479-796
Range on HMM: 1-486/486
Sequence Identity: 24% (120 aa)

VRKDQTLGSGCFG---EVFKGFLQKNYVLTKRRLSHDHDLH--SRRGSLPQETYPVAVKKLK--SIADGKERSD-----------FLKEIEVMKTVSSTD
..  ..||.| ||   ||.|| ..    .  .| ...       ....  ... ||||| ||  . .. .|. |           ||.| |.||  ... 
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMT-VTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSL

SDLRRFVVNMLGCCSLE------------EPMLLVVEFVENGD----LLNYLRRMKRKAQGNNSTAPPAPYLEPLGSYSLLEPKSELDNEGF--------
 .    .|...|.|. .            ||...|.|....||    |..|||. ..|.| . .. .. .  .|  .  ...         .        
GH-HPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSK-LHHC---------MKGDITYSH

-------------------------------------------LTERNLLDFSRQIASGMEYLSSL------GIIHRDLACRNVLVGKEKN---------
                                           || . || ...|||.|||||.|.      ...|||||.||.|||....         
ESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCG

--LKISDFG--------LSRVVLSDMVYTLTN------------------------HGRLPLRWMALESIFQRE---------FTTSSDVWSYGVALWEI
   ||.|||        |.| . ||  |. ..                         |.||.|||| |... |.         ||| |||||.|| .|||
PVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEI

CTMG-AFPYATMQE---------KELLKLLKKG--------------YRLPKPQNCS--------------QDMFEVMHQCWHPNPQGRPTFSNLHKLF
.| | . .|  |           .|....|..|              .|.|.|..|.              ......| ||||..|. ||||| ||. .
FTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase AqueK397.AA UTK 479-796 29 9.4e-91 307.81 In-house 1-296 (296) Show / Hide 
Range on Protein: 479-796
Range on HMM: 1-296/296
Sequence Identity: 29% (105 aa)

VRKDQTLGSGCFGEVFKGFLQK-------NYVLTKRRLSHDHDLHSRRGSLPQETYPVAVKKLKSIADGKERS---DFLKEIE---VMKTVSSTDSDLRR
|.  ..||.| ||||.|. ...        .|  | .                          .. .. .|.    ||..|     .|| ..      ..
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQ-------------------------HHADAQQEPEPYPDFMEEARELQMMKQFH-----WHP

FVVNMLGCCSLEEPMLLVVEFVENGDLLNYLRRMKRKAQGNNSTAPPAPYLEPLGSYSLLEPKSELDNEGFLTERNLLDFSRQIASGMEYLSSLGIIHRD
 |....| |. |||...|.|. |||||..|||| ....                            ... .||.. .|.....||.||.||.| |..|||
NVLRLVGVCTQEEPWMIVTEYMENGDLRSYLRRHRPTPP---------------------------ACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRD

LACRNVLVGKE-------KNLKISDFG---LSRVVL---------SDMVYTLTNHGRLPLRWMALESIFQR-EFTTSSDVWSYGVALWEICTMGAFPYAT
||.||.||..           ||.|||   .|| |          ..  |. .. .|.|.|||| |.. ..  |||.|||||.|| .|||.|.|. ||. 
LAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPG

MQEKELLKLLKKG--YRLPKPQNCSQDMFEVMHQCWHPNPQGRPTFSNLHKLF
| . .... . .|  ||.|.|. |. .....||.|||..|| ||.|  | . .
MSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase AqueK397.AA TK-Unique 479-796 33 1.4e-90 307.24 In-house 1-294 (294) Show / Hide 
Range on Protein: 479-796
Range on HMM: 1-294/294
Sequence Identity: 33% (111 aa)

VRKDQTLGSGCFGEVFKGFLQKNYVLTKRRLSHDHDLHSRRGSLPQETY-PVAVKKLKSIADGKERSDFLKEIEVMKTVSSTDSDLRRFVVNMLGCCSLE
.. ....|.| ||.|..| . ..                     ...    ||||.||  |.. ...||||||..|| .     .    .|..||||   
LEVGDVIGEGAFGQVWRGEVWGIW-------------------KHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKEL-----GDHPNIVQCLGCCTKS

-EPMLLVVEFVENGDLLNYLRRMKRKAQGNN---------STAPPAPYLEPLGSYSLLEPKSELDNEGFLTERNLLDFSRQIASGMEYLSS--LGIIHRD
 ||.... |....|.|..|||...... ...          ..|. | .||. . .|.                   |  |||.|||||.|   .|.|||
DEPWMIIMEYCPCGNLQHYLRTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYH------------------FAWQIACGMEYLASQRKKIVHRD

LACRNVLVGKEKNLKISDFGLSRVVLSDMVYTLT-NHGRLPLRWMALESIF--QREF-TTSSDVWSYGVALWEICTMGAFPYATMQEKELLKLLKKGYRL
|. ||||..  |..||.|||..| |  . ||  .   ||.|.||||.||.   .. . || |||||.|| .|||.|.||.||  |  |........|||.
LCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRM

PKPQNC-SQDMFEVMHQCWHPNPQGRPTFSNLHKLF
|.|..| |..|...| .||. .|. ||.|. . . .
PQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase AqueK397.AA KIN6 527-796 35 1e-81 269.77 In-house 45-305 (305) Show / Hide 
Range on Protein: 527-796
Range on HMM: 45-305/305
Sequence Identity: 35% (99 aa)

YPVAVKKLKSIADGKERSDFLKEIEVMKTVSSTDSDLRRFVVNMLGCCSLEEPMLLVVEFVENGDLLNYLRRMKRKAQGNNSTAPPAPYLEPLGSYSLLE
...|||.| | ||  ...||..||. ||.    .      .|||||| .  .. .||||. ...||| |||  .. .            |. ||      
CQCAVKMLPSHADEMAHHDFMHEIAFMKQLGHHP-----HLVNMLGCVTNSYKPCLVVEYCCHMDLLKYLRNRCQYMMN----------LDDLGINYHCP

PKSE-LDNEGFLTERNLLDFSRQIASGMEYLSSLGIIHRDLACRNVLVGKEK---NLKISDFGLSRVVLSDMVYTLTNHGR-LPLRWMALESIFQREFTT
. ..  | .  .. . |. |. ||. |||||.| ..|||||| ||||| .       ||||||| |  . |     .  || ||..|||.|..   || .
DENSRYDDMMCIRHKDLYMFAWQICDGMEYLHSKNCIHRDLAARNVLVTEGCRMKTCKISDFGLCRYPYMDQFQYTSKGGRYLPIKWMAPECLKHYEFSY

SSDVWSYGVALWEICTMGAFPYATMQ-EKELLKLLKKGYRLPKPQNCSQDMFEVMHQCWHPNPQGRPTFSNLHKLF
 |||||.|| ..|. ..|  ||..||   |..  ...| |. .| .|.   ...| .||   |  || |. . ..|
KSDVWSFGVLMFEMFSLGDVPYPEMQRPTEMIEHHRSGRRPKHPKWCPEEIYDIMQSCWQEKPDDRPEFNEMRMQF
Kinase AqueK397.AA FGFR 523-796 41 1.1e-81 277.65 In-house 28-293 (293) Show / Hide 
Range on Protein: 523-796
Range on HMM: 28-293/293
Sequence Identity: 41% (113 aa)

PQETYPVAVKKLKSIADGKERSDFLKEIEVMKTVSSTDSDLRRFVVNMLGCCSLEEPMLLVVEFVENGDLLNYLRRMKRKAQGNNSTAPPAPYLEPLGSY
|...  ||||.||. .  |. ||   |.|.|| .          ..| ||||. | |   .||. . | |  .||  .|   |      .  |....   
PEKEITVAVKMLKMNHTDKDLSDLVSEMEMMKMIGK-----HKNIINLLGCCTQEGPLYVIVEYCHHGNLRDFLR--ARRPPGMDYKKDSQEYTDYK--P

SLLEPKSELDNEGFLTERNLLDFSRQIASGMEYLSSLGIIHRDLACRNVLVGKEKNLKISDFGLSRVVLSDMVYTLTNHGRLPLRWMALESIFQREFTTS
.  | . ...    ||.. |  .  |.| ||||| |  .|||||| |||||. .  .||.||||.| . .   |  |  ||||  |||.|. | | .|. 
RKPEQQDDIELIPNLTQKDLVSCAYQVARGMEYLASRKCIHRDLAARNVLVTDDYVMKICDFGLARDIHCIDYYRKTTNGRLPIKWMAPEALFDRVYTHQ

SDVWSYGVALWEICTMGAFPYATMQ-EKELLKLLKKGYRLPKPQNCSQDMFEVMHQCWHPNPQGRPTFSNLHKLF
|||||||| |||| | |  || .     || |.|| |.|. ||.||||... .| |||| .|. ||||  |   .
SDVWSYGVLLWEIMTYGGQPYPHIPSVEELYKYLKEGHRMEKPHNCSQEIYHMMCQCWHFKPCQRPTFKQLVEYL
Kinase AqueK397.AA Src 528-796 36 1.1e-80 273.89 In-house 25-255 (255) Show / Hide 
Range on Protein: 528-796
Range on HMM: 25-255/255
Sequence Identity: 36% (99 aa)

PVAVKKLKSIADGKERSDFLKEIEVMKTVSSTDSDLRRFVVNMLGCCSLEEPMLLVVEFVENGDLLNYLRRMKRKAQGNNSTAPPAPYLEPLGSYSLLEP
.|||| ||.     .  .||.|...||...         .|...  || ||| . | |. ..| || ||..                             
KVAVKTLKPGT--MSPEAFLQEAQIMKKLRHEK------LVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKK-----------------------------

KSELDNEGF-LTERNLLDFSRQIASGMEYLSSLGIIHRDLACRNVLVGKEKNLKISDFGLSRVVL-SDMVYTLTNHGRLPLRWMALESIFQREFTTSSDV
    | ||  |  ..|.|.. |.|.||.||.|  .|||||| ||||||..   |. |||| |..   | .|.     ..| .|.| | |  . ||. |||
----DGEGRHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDV

WSYGVALWEICTMGAFPYATMQEKELLKLLKKGYRLPKPQNCSQDMFE-VMHQCWHPNPQGRPTFSNLHKLF
||.|. |.|| | |  ||  |. .| |. ...|||.|.|.|| . ..| .| ||||  |. ||||  |.. .
WSFGILLTEIVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase AqueK397.AA VEGFR 529-796 35 7.8e-76 258.25 In-house 32-332 (332) Show / Hide 
Range on Protein: 529-796
Range on HMM: 32-332/332
Sequence Identity: 35% (108 aa)

VAVKKLKSIADGKERSDFLKEIEVMKTVSSTDSDLRRFVVNMLGCCSL---EEPMLLVVEFVENGDLLNYLRRMKRKA----------------------
||||.||. |.  |    . |..... .          |||.||||       |..  ||..  | |.||| | ||..                      
VAVKMLKEGATASEHRALMSELKMLIHIGH-----HLNVVNFLGCCTKNIQKGPLMVIVEYCCFGNLSNYL-RTKRMYFVPYPDKSPHMRQRKECMGPQD

---------QGNNSTAPPAPYLEPLGSYS---LLEPKSELDNEGFLTERNLLDFSRQIASGMEYLSSLGIIHRDLACRNVLVGKEKNLKISDFGLSRV-V
          || . .  .  .. ..||.     |  ...  . .||   |. .| |.| |||.|.|  .|||||| ||.|.   . .||.||||.|   
HQDHKRRRDSGNSFQSSFGSFFRMKKSYDDVEPDEVFEDMW-KDPLTMEDLICYSFQVARGMEFLASRKCIHRDLAARNILLCENNVVKICDFGLARHGI

LSDMVYTLTNH-GRLPLRWMALESIFQREFTTSSDVWSYGVALWEICTMGAFPYATMQ-EKELLKLLKKGYRLPKPQNCSQDMFEVMHQCWHPNPQGRPT
 .|  |      ||||..|||.|||| . .|| |||||||| |||| . |. || . |   |. . || |||. .|  | . . ..| .|||..|  ||.
YKDPDYVRKGDQGRLPIKWMAPESIFDKVYTTYSDVWSYGVFLWEIFSLGGSPYPGVQIDEEFCNRLKDGYRMRAPDYCTPEIYHIMLDCWHKEPEERPH

FSNLHKLF
|| | . .
FSELVEHL
Kinase AqueK397.AA RTKB 637-796 42 3.9e-67 225.35 In-house 106-264 (264) Show / Hide 
Range on Protein: 637-796
Range on HMM: 106-264/264
Sequence Identity: 42% (69 aa)

LTERNLLDFSRQIASGMEYLSSLGIIHRDLACRNVLVGKEKNLKISDFGLSRVVLSDMVYTLTNHGRLPLRWMALESIFQREFTTSS-DVWSYGVALWEI
|  ..|.||..|||.|| .|.. ..|||||. |||||...   ||.|||..|  . .  |..| . ||| .||| ||. .| .|| | ||||.||  |||
LKQAQLVDFCHQIACGMAFLHQHNVIHRDLCARNVLVDQQLHCKICDFGMAR-EIDHECYETTCT-RLPIKWMAPESWAHRIYTTKSGDVWSFGVTMWEI

CTMGAFPYATMQEKELLKLLKKGYRLPKPQNCSQDMFEVMHQCWHPNPQGRPTFSNLHKLF
 ..|. ||.. .  .....| .|.|||||.  .| ....| .||   .| ||.|. | ..|
FSLGGTPYQQYRNGDIFYWLESGHRLPKPRQMPQAADHIMQMCWQMEAQHRPDFDELVDAF
Kinase AqueK397.AA EGFR 640-797 44 2.3e-66 219.27 In-house 101-258 (258) Show / Hide 
Range on Protein: 640-797
Range on HMM: 101-258/258
Sequence Identity: 44% (71 aa)

RNLLDFSRQIASGMEYLSSLGIIHRDLACRNVLVGKEKNLKISDFGLSRVVLSDMVYTLTNHGRLPLRWMALESIFQREFTTSSDVWSYGVALWEICTMG
..|| .. |||.||.||    ..||||| ||||| . .  || ||||...  .|      . |..| .|||||.| .| .|  |||||||| .||. | |
QHLLNWCVQIAKGMQYLEEHRMVHRDLAARNVLVKSPNHVKITDFGLAKLLEHDEKEYHAQGGKMPIKWMALECIHHRCYTHQSDVWSYGVTCWELMTFG

AFPYATMQEKELLKLLKKGYRLPKPQNCSQDMFEVMHQCWHPNPQGRPTFSNLHKLFD
. ||. .. .|   ||.|| ||| |..|..|.. || .||.  .. ||||  | . |.
QKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDEDMRPTFKELYEEFK
Kinase AqueK397.AA Eph 633-796 42 3.1e-59 197.58 In-house 98-264 (264) Show / Hide 
Range on Protein: 633-796
Range on HMM: 98-264/264
Sequence Identity: 42% (71 aa)

NEGFLTERNLLDFSRQIASGMEYLSSLGIIHRDLACRNVLVGKEKNLKISDFGLSRVVLSDM----VYTLTNHGRLPLRWMALESIFQREFTTSSDVWSY
..| .|   |.   | ||||| |||... .||||| ||.|| ..   |.||||||||. .|     .|| |. |. |.|| | | |  | ||..||||||
HDGQFTVIQLVGMLRGIASGMKYLSDMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPSVEATYT-TRGGKIPIRWTAPEAIAYRKFTSASDVWSY

GVALWEICTMGAFPYATMQEKELLKLLKKGYRLPKPQNCSQDMFEVMHQCWHPNPQGRPTFSNLHKLF
|. .||... |  ||  | ... .|   .||||| | .| . ... | .||.  .. ||.|....  .
GIVMWEVMSYGERPYWDMSNQDVIKAIEQGYRLPPPMDCPEALHQLMLDCWQKDRNHRPHFQQIVSIL
Kinase AqueK397.AA Pkinase 479-796 19 3.4e-36 129.04 Pfam 1-293 (293) Show / Hide 
Range on Protein: 479-796
Range on HMM: 1-293/293
Sequence Identity: 19% (70 aa)

VRKDQTLGSGCFGEVFKGFLQKNYVLTKRRLSHDHDLHSRRGSLPQETYPVAVKKLK--SIADGKERSDFL-KEIEVMKTVSSTDSDLRRFVVNMLGCCS
 .. ...||| ||.|.|.  ...                           ||||..|  .. ..|......  ||..|| ..        ..| ..... 
YHIGRKIGSGSFGCVYKCHHKGTGK------------------------IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN------HPNIVRLYDWFE

LEEPMLLVVEFVENG----DLLNYLRRMKRKAQGNNSTAPPAPYLEPLGSYSLLEPKSELDNEGFL--TERNLLDFSRQIASGMEYLSSLGIIHRDLACR
 .  . .| |..|.|    ||  |...                                 ...| .  .|. . .. .||..|.||. | |||||||   
DKDHIYMVMEYCEGGLYVMDLFDYIST---------------------------------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPE

NVLVGKEKNL----KISDFGLSRVVLSDMVYTLTNHGRLPLRWMALESIF-QREFTTSSDVWSYGVALWEICTMGAFPYATM-------QEKELLKLLKK
|.|. .. ..    ||.||||....     .. ...    ...|| | |  ... ....|.||.|. |.| .. | .|.          | . . . ...
NILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGP

GYRLPKPQNCS-------------------QDMFEVMHQCWHPNPQGRPTFSNLHKL--F
 .. . |. ||                   ... ...  |....|. |||.  . .   |
PLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase AqueK397.AA S_TKc 479-799 19 6.1e-31 110.02 SMART 1-231 (231) Show / Hide 
Range on Protein: 479-799
Range on HMM: 1-231/231
Sequence Identity: 19% (65 aa)

VRKDQTLGSGCFGEVFKGFLQKNYVLTKRRLSHDHDLHSRRGSLPQETYPVAVKKLKSIADGKERSDFLKEIEVMKTVSSTDSDLRRFVVNMLGCCSLEE
 .. ...|.| ||.|.|.   |                            ||.|..|         ....||...|           ..|......   .
YEILRKIGKGAFGKVYKCRHKK------------------------TGRIVAIKIIK--------EHIRREIQILKK-------HHPNIVKLYDVFQD-D

PMLLVVEFVEN--GDLLNYLRRMKRKAQGNNSTAPPAPYLEPLGSYSLLEPKSELDNEGF---LTERNLLDFSRQIASGMEYLSSLGIIHRDLACRNVLV
 . .| |....  |||. |.....|.                                |    ..|     . .||....||. |.|||||||   |.|.
HLYMVMEYCDGDLGDLFDYIKKRGRH--------------------------------GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILL

GKEKNLKISDFGLSRVVLSDMVYTLTNHGRLPLRWMALESIFQREFTT-SSDVWSYGVALWEICTMGAFPYATMQEKELLKLLKKGYRLPKPQNCSQDMF
 .  ..||.||||.|..         ..    . .|| | .    ... ..|.|| |. |.| .. |  |.   |.....|...           |... 
DE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC-GYPPFP--QMQMMFKKIG-----------SPEAK

EVMHQCWHPNPQGRPTFSNLHK------LFDYF
. . .|.. .|. |||   . .      .  .|
DFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase AqueK397.AA Eph 479-598 25 5.7e-12 36.35 In-house 1-97 (264) Show / Hide 
Range on Protein: 479-598
Range on HMM: 1-97/264
Sequence Identity: 25% (31 aa)

VRKDQTLGSGCFGEVFKGFLQKNYVLTKRRLSHDHDLHSRRGSLPQETYPVAVKKLKSIADGKERSDFLKEIEVMKTVSSTDSDLRRFVVNMLGCCSLEE
.. .. .|.| |||| .| |...   .. ...                 |||.| ||. .  |.| ||| |  .|   .         ..   |  .  .
IKIEKVIGAGEFGEVCCGRLKLPSGKREVWVD-----------------PVAIKTLKAGYTEKQRWDFLSEASIMGQFDHPN------IIRLEGVVTKSR

PMLLVVEFVENGDLLNYLRR
|.  |.|. ||| |  .||.
PVMIVTEYMENGSLDSFLRQ
Kinase AqueK397.AA RTKB 479-597 31 2.7e-11 34.36 In-house 1-94 (264) Show / Hide 
Range on Protein: 479-597
Range on HMM: 1-94/264
Sequence Identity: 31% (37 aa)

VRKDQTLGSGCFGEVFKGFLQKNYVLTKRRLSHDHDLHSRRGSLPQETYPVAVKKLKSIADGKERSDFLKEIEVMKTVSSTDSDLRRFVVNMLGCCSLEE
|. .. ||.| |||||.....  .  |...                    .|.| ||  |   || ||..|. |||..          |. ..| |  .|
VWLGEKLGNGAFGEVFQAWVRNRHMNTEQS--------------------CAAKVLKPGASYEERQDFCSEMTVMKEL-----GWHPNVIGIIGHCLQDE

PMLLVVEFVENGDLLNYLR
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PYILLVELCELGNLRDYLR
Kinase AqueK397.AA EGFR 479-496 55 4e-06 16.09 In-house 1-18 (258) Show / Hide 
Range on Protein: 479-496
Range on HMM: 1-18/258
Sequence Identity: 55% (10 aa)

VRKDQTLGSGCFGEVFKG
..|.. |||| || |.||
LKKVKVLGSGAFGTVYKG
Kinase AqueK397.AA KIN6 479-496 50 1.3e-05 14.27 In-house 1-18 (305) Show / Hide 
Range on Protein: 479-496
Range on HMM: 1-18/305
Sequence Identity: 50% (9 aa)

VRKDQTLGSGCFGEVFKG
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IHKDHKLGHGAFCNVYKG
Kinase AqueK397.AA EGFR 528-600 32 2.8e-05 13.29 In-house 30-95 (258) Show / Hide 
Range on Protein: 528-600
Range on HMM: 30-95/258
Sequence Identity: 32% (24 aa)

PVAVKKLKSIADGKERSDFLKEIEVMKTVSSTDSDLRRFVVNMLGCCSLEEPMLLVVEFVENGDLLNYLRRMK
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PVAIKVLREQTGPKANEEMLDEAYVMASVDHP------HLVRLLGVCMHSQ-MQLVTQYMPYGCLLDYVRQHK
Kinase AqueK397.AA Src 479-496 44 0.000129 11.55 In-house 1-18 (255) Show / Hide 
Range on Protein: 479-496
Range on HMM: 1-18/255
Sequence Identity: 44% (8 aa)

VRKDQTLGSGCFGEVFKG
..  . ||.|.||||..|
IKLCRKLGQGQFGEVWMG
Kinase AqueK397.AA FGFR 483-496 50 0.105341 1.52 In-house 5-18 (293) Show / Hide 
Range on Protein: 483-496
Range on HMM: 5-18/293
Sequence Identity: 50% (7 aa)

QTLGSGCFGEVFKG
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KMLGEGCFGQVWMA