Gene AqueK253 (A.queenslandica)
AqueK253
Species: A.queenslandica
Alias: AqueK253
External Links:
Annotation:
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| AqueK253.AA | Protein | None | 213 | None | Fasta, JSON |
| AqueK253.kin_dom | Protein Kinase Domain | None | 248 | None | Fasta, JSON |
Protein domains of AqueK253.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | AqueK253.AA | Pkinase_Tyr | 15-207 | 41 | 5.6e-84 | 285.05 | Pfam | 57-241 (270) | Show / Hide |
Range on Protein: 15-207 Range on HMM: 57-241/270 Sequence Identity: 41% (82 aa) MMSF-DNVNVLHLIGVCI-DMGP-APYIVMPFMAKGSLLSYLKKERHNLTVAESSDDDIVLDVRKKLVSICLQVAKGMCYLASHNFIHRDLASRNCMIDD |... .. |.. |.|||. . .| .||||..|..|.||.||.| | .|. |.. |...|.|.|||| ||.|.|.|||||| |||.... MKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHR---------EDKQPLTMKD-LLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE HGIIKVADFGLTEEVYANNYFKQLKDNNASVKLPIKWMALESLHDGLFSEKSDVWSYGVLCWEVFSLGRTP-YPGLDPAGVVDLL-DTGGRLQCPHNT ...|..||||. .| | | .. |||||||.|....| |..||||||.|||.||.|..|..| |||.... |.... . |.|. ||.|. NNVVKICDFGLARDIYNDDYY-YRKRGGGK--LPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENC |
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| Kinase | AqueK253.AA | TK | 11-213 | 21 | 8.2e-70 | 232.97 | In-house | 90-461 (486) | Show / Hide |
Range on Protein: 11-213
Range on HMM: 90-461/486
Sequence Identity: 21% (81 aa)
ECIRMMS---FDNVNVLHLIGVCIDMG-----------PAPYIVMPFMAKGS----LLSYLKKERHNLTVAESSDDDIVLDVRK----------------
| . ||. .. |...|.||| . . . ..||| .|..|. |..||.| |.. . ... |. ...
EEMKMMCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHE
----------------------------------------------KLVSICLQVAKGMCYLASH------NFIHRDLASRNCMIDDHGI----------
|. .|.|.|.|| ||.|. ||.||||| |||.......
SNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGP
-IKVADFG--------LTEEVYAN-NYFKQLKDNNA-------------------SVKLPIKWMALESLHDGL---------FSEKSDVWSYGVLCWEVF
.|.|||| |. ..| . .| .. . . ||||.||| |.| |. |..||||||.|||.||.|
VCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIF
SLGRTPYPG-LDP---------AGVVDLLDTGGR------------LQCPHNTACS--------------QEM
..|..||.| .. . |...| .||| ...| |. .|.
TYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEY
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| Kinase | AqueK253.AA | Met | 11-204 | 39 | 4.1e-64 | 209.01 | In-house | 51-244 (271) | Show / Hide |
Range on Protein: 11-204 Range on HMM: 51-244/271 Sequence Identity: 39% (83 aa) ECIRMMSFDNVNVLHLIGVCIDMGP-APYIVMPFMAKGSLLSYLKKERHNLTVAESSDDDIVLDVRKKLVSICLQVAKGMCYLASHNFIHRDLASRNCMI | | | || ||| |||.|.| |..| |.|..| |... . . .|..| . |.. |.|||||| |.|| |.||||| ||||. EGIMMKHFDHPNVLSLIGICLDPEGHMPWVVLPYMKHGDLKTFIRNPQNNPCV-------------RDLIEFCHQVAKGMMYMASQKFVHRDLACRNCML DDHGIIKVADFGLTEEV-YANNYFKQLKDNNASVKLPIKWMALESLH--------DGL-FSEKSDVWSYGVLCWEVFSLGRTPYPGLDP-AGVVDLLDTG | | ..||||||| . | | | .. . .||.||||.|.| . |. |||||| ||. || . | .||| |. . | .| DEHFTVKVADFGLCRDMDYDKEYYSQ-MHHTHPARLPVKWMAPECLQQGVCLGCPTYRQFTTKSDVWSFGVVMWELMTRGAPPYPHVDNWFDITHWLHQG --GRLQCP || | ETRRLPQP |
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| Kinase | AqueK253.AA | TK-Unique | 22-213 | 31 | 3.1e-62 | 213.06 | In-house | 65-269 (294) | Show / Hide |
Range on Protein: 22-213 Range on HMM: 65-269/294 Sequence Identity: 31% (67 aa) NVLHLIGVCIDMGPAPYIVMPFMAKGSLLSYLKKERHN-----------LTVAESSDDDIVLDVR-KKLVSICLQVAKGMCYLAS--HNFIHRDLASRNC |.....|.|.. . ..|.|.....|.|..||.. | . ... |.. .. | |.... |.|.|| |||| ....||||..||. NIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNV MIDDHGIIKVADFGLTEEVYANNYFKQLKDNNASVKLPIKWMALESLH--DGLF-SEKSDVWSYGVLCWEVFSLGRTPYPGLDPAGVVDLLDTGGRLQCP .. .....|..|||....||. ... . . ..||.|||.||| .| . ..||||||.||| ||.|.|| .||||.... ..... | |.. | LLTEDKVCKICDFGMARDVYT---NGVYSMMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQP HNTAC-SQEM . | |.|| EH--CCSHEM |
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| TyrKc | AqueK253.AA | TyrKc | 1-213 | 26 | 1.1e-58 | 202.25 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 1-213
Range on HMM: 1-280/280
Sequence Identity: 26% (77 aa)
TQND-----------------------------VESIVDECIRMMSF--DNVNVLHLIGVCIDMG------PAPYIVMPFMAKGSLLSYLKKERHNLTVA
. . .| . .| |... .. |.. |.|||.. | . ..||| .|..|.|..||.| |..
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK----
ESSDDDIVLDVRKKLVSICLQVAKGMCYLASHNFIHRDLASRNCMIDDHGIIKVADFGLTEEVYAN-------NYFKQLKDNNASVKLPIKWMALESLHD
|.|.|.|.|.|.|| ||.|.|.|||||| |||.... ...|..||||. ..| | .. . .. |||.|||.|.. .
---------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINY
GLFSEKSDVWSYGVLCWEVFSLGRTPYPG-----LDPAGVVDLLDTGGRLQCPHN-------------------------------TACSQEM
| |..||||||.||..||.|..| .|||| .... |. ....|.|. .|.| ... ...
GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
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| Kinase | AqueK253.AA | UTK | 15-213 | 34 | 6.7e-57 | 193.19 | In-house | 63-271 (296) | Show / Hide |
Range on Protein: 15-213 Range on HMM: 63-271/296 Sequence Identity: 34% (74 aa) MMSFD-NVNVLHLIGVCIDMGPAPYIVMPFMAKGSLLSYLKKERHNLTVAESSDDDIVLDVRKK-LVSICLQVAKGMCYLASHNFIHRDLASRNCMIDDH |. |. .||| |.||| . .| ..||. .|..|.|.||| . |... . . ... ... ....| || ||.|..|.||||| ||| ...| MKQFHWHPNVLRLVGVCTQEEP-WMIVTEYMENGDLRSYLRRHRPTPP-------ACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMH G-------IIKVADFG---LTEEVY----ANNYFKQLKDNNA-SVKLPIKWMALESLHDG-LFSEKSDVWSYGVLCWEVFSLGRTPYPGLDPAGVVDLLD . ..|.|||| .. .|. .| | .. . . ..||.||| |.| .. |..||||||.||.|||... ||.||||. . |. . RMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVC TGGRLQCPHNTACSQEM |||.. | . .|. .. NGGRYRMPCPWDCPHPV |
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| Kinase | AqueK253.AA | Src | 22-206 | 39 | 1.5e-54 | 183.74 | In-house | 55-224 (255) | Show / Hide |
Range on Protein: 22-206 Range on HMM: 55-224/255 Sequence Identity: 39% (74 aa) NVLHLIGVCIDMGPAPYIVMPFMAKGSLLSYLKKERHNLTVAESSDDDIVLDVRKKLVSICLQVAKGMCYLASHNFIHRDLASRNCMIDDHGIIKVADFG ....| || . | ||| .|..|||| |||| ... | .. .|... |||.||.|| | |.|||||| || .... . |||||| KLVQLYAVCSQEEPI-YIVTEYMSHGSLLDYLKK----------DGEGRHLHLP-QLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFG LTEEVY--ANNYFKQLKDNNASVKLPIKWMALESLHDGLFSEKSDVWSYGVLCWEVFSLGRTPYPGLDPAGVVDLLDTGGRLQCPHN | . ..| . |.||||.| | .. | |. ||||||.|.| .|... ||.|||| . . |.. .. | |. |||| LARLIKEDDDEYCARH-----GAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGRVPYPGMTNHEVLQQVERGYRMPCPHN |
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| Kinase | AqueK253.AA | Axl | 1-206 | 40 | 2.7e-51 | 176.74 | In-house | 41-239 (267) | Show / Hide |
Range on Protein: 1-206 Range on HMM: 41-239/267 Sequence Identity: 40% (85 aa) TQNDVESIVDECIRMMSFDNVNVLHLIGVCIDMG-----PAPYIVMPFMAKGSLLSYLKKERHNLTVAESSDDDIVLDVRKKLVSICLQVAKGMCYLASH || ..| . | . | || ||..|||||| | |.| ...||| | | ..| | . |. . | . . || . .| || ||... TQSEIEEFLSEAACMKEFDHPNVMRLIGVCIQMSERQRIPKPMVILPFMKHGDLHTFLLYSRLG-------DQPFYLPL-QMLVKFMVDIACGMEYLSNR NFIHRDLASRNCMIDDHGIIKVADFGLTEEVYANNYFKQLKDNNASVKLPIKWMALESLHDGLFSEKSDVWSYGVLCWEVFSLGRTPYPGLDPAGVVDLL |||||||| ||||. . . |||||| .|. |..| |.|.||.|.||| | .. |||||..|| ||. |.|||||.. . . | | NFIHRDLAARNCMLREDMTVCVADFGLSKKIYSGDYYRQ----GCIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIMTRGQTPYPGVENHEMYDYL DTGGRLQCPHN | ||. |.. IHGHRLKQPED |
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| Kinase | AqueK253.AA | FGFR | 20-213 | 35 | 1.2e-50 | 170.86 | In-house | 64-268 (293) | Show / Hide |
Range on Protein: 20-213 Range on HMM: 64-268/293 Sequence Identity: 35% (76 aa) NVNVLHLIGVCIDMGPAPYIVMPFMAKGSLLSYLKKERHNLTVAESSDD-------DIVLDV----------RKKLVSICLQVAKGMCYLASHNFIHRDL . |.. |.|.| || .|.. . ..| | .|.. | .... . . .. |.|||. |||.|| |||| ||||| HKNIINLLGCCTQEGP-LYVIVEYCHHGNLRDFLRARRPPGMDYKKDSQEYTDYKPRKPEQQDDIELIPNLTQKDLVSCAYQVARGMEYLASRKCIHRDL ASRNCMIDDHGIIKVADFGLTEEVYANNYFKQLKDNNASVKLPIKWMALESLHDGLFSEKSDVWSYGVLCWEVFSLGRTPYPGLD-PAGVVDLLDTGGRL | || . | ..|..|||| . . |.. | | |||||||.|.| | . .||||||||| ||.. .| .|||. ..| .| |. AARNVLVTDDYVMKICDFGLARDIHCIDYYR--KTTNG--RLPIKWMAPEALFDRVYTHQSDVWSYGVLLWEIMTYGGQPYPHIPSVEELYKYLKEGHRM QCPHNTACSQEM ||| ||||. EKPHN--CSQEI |
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| Kinase | AqueK253.AA | Fer | 15-185 | 39 | 6.3e-50 | 168.25 | In-house | 62-221 (283) | Show / Hide |
Range on Protein: 15-185 Range on HMM: 62-221/283 Sequence Identity: 39% (69 aa) MMS-FDNVNVLHLIGVCIDMGPAPYIVMPFMAKGSLLSYLKKERH-NLTVAESSDDDIVLDVRKKLVSICLQVAKGMCYLASHNFIHRDLASRNCMIDDH |.. .| || ..||| | | .||| |. |||.|||||. . .....| .. .|.|.|.|| || |.| ||||.|.||| .... MRNNYDHPNVVKFYGVCVDEQPI-MIVMEFCNGGSLDSYLKKNKNKTVSDNE-------------KIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKD GIIK---VADFGLTEEVYANNYFKQLKDNNASVKLPIKWMALESLHDGLFSEKSDVWSYGVLCWEVFSLGRTPYPG .. | ..|||. . . | ...|. .. |.||.|.| |.. .|..|.|.||||.||.|||.|. | .|||| KVKKKCKISDFGMSRQCSDYGYDYKMKE--KACKVPIRWLAPETWQTGIYSPKTDVWSFGVMCWEIFTNGAEPYPG |
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| Kinase | AqueK253.AA | InsR | 15-186 | 37 | 2.3e-49 | 163.93 | In-house | 58-225 (278) | Show / Hide |
Range on Protein: 15-186 Range on HMM: 58-225/278 Sequence Identity: 37% (66 aa) MMSFDNVNVLHLIGVCIDMGPAPYIVMPFMAKGSLLSYLKKERHNLTVAESSDDDIVLD------VRKKLVSICLQVAKGMCYLASHNFIHRDLASRNCM | |. .| | ||| |. |.|| .|..| | ||| |. .... . .... ... || |||. .|.||||| |||| MKEFNCHHVVRLLGVCSRGQPM-YVVMEMMTYGDLKSYLRSRRPEEEF-----NNPGCNRNQHVPCLDQMHQMAAEICDGMAYLAAKKFVHRDLACRNCM IDDHGIIKVADFGLTEEVYANNYFKQLKDNNASVKLPIKWMALESLHDGLFSEKSDVWSYGVLCWEVFSLGRTPYPGL ... . .|..|||.| .| | . . .||. ||| ||| || |. .|||||.||. ||. .|| || || VNHDFTVKIGDFGMTRDIYEHDYYRKGGKG----MLPVRWMAPESLKDGVFTTHSDVWSFGVVLWEMVTLGEQPYQGL |
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| Kinase | AqueK253.AA | Tec | 28-205 | 40 | 4.9e-49 | 169.23 | In-house | 61-221 (254) | Show / Hide |
Range on Protein: 28-205 Range on HMM: 61-221/254 Sequence Identity: 40% (73 aa) GVCIDMGPAPYIVMPFMAKGSLLSYLKKERHNLTVAESSDDDIVLDVRKK--LVSICLQVAKGMCYLASHNFIHRDLASRNCMIDDHGIIKVADFGLTEE |||. | ||| .|..|.||.||....| . .. | ..|..| .|| || .|.||||||| ||| ..| ...||.|||.| GVCSQQRPI-YIVTEYMEHGCLLNYLREHKHHFQ-------------KNMAILLEMCQDVCEGMAYLERHCFIHRDLAARNCLVGDQCVVKVSDFGMTRY VYANNYFKQLKDNNASV--KLPIKWMALESLHDGLFSEKSDVWSYGVLCWEVFSLGRTPYPGLDPAGVVDLLDTGGRLQCPH | | || | |.|| . | .| .| |||||..||| |||||.|. ||. .. ||. .| || || VLDDQYT-------SSVGTKFPVKWCPPEVFHYSRYSSKSDVWAFGVLMWEVFSCGKMPYENMSNSEVVEHVSQGHRLYRPH |
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| Kinase | AqueK253.AA | Pkinase | 22-122 | 24 | 3.8e-13 | 47.55 | Pfam | 61-158 (293) | Show / Hide |
Range on Protein: 22-122 Range on HMM: 61-158/293 Sequence Identity: 24% (28 aa) NVLHLIGVCIDMGPAPYIVMPFMAKG----SLLSYLKKERHNLTVAESSDDDIVLDVRKKL-------VSICLQVAKGMCYLASHNFIHRDLASRNCMID |.. |.... | .. .|.||... .| .| .|.. . .... ....|...|. |. |...||||| . |..|| NIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDYIST-----------------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID DHGII----KVADFGL ..| | |..|||| NNGHIDACVKICDFGL |
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| Kinase | AqueK253.AA | S_TKc | 2-213 | 19 | 2.6e-11 | -11.0 | SMART | 19-231 (231) | Show / Hide |
Range on Protein: 2-213 Range on HMM: 19-231/231 Sequence Identity: 19% (48 aa) QNDV-----------ESIVDECIRMMSFDNVNVLHLIGVCIDMGPAPYIVMPFMAK--GSLLSYLKKERHN-----LTVAESSDDDIVLDVRKKLVSICL .. |.| | ... . |. .|..|. | |.|| .. |.|..|.|| ... .. . ... RHKKTGRIVAIKIIKEHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-H-------------ARFYMY QVAKGMCYLASHNFIHRDLASRNCMIDDHGIIKVADFGLTEEVYANNYFKQLKDNNASVKLPIKWMALESLHDGLFSE-KSDVWSYGVLCWEVFSLGRTP |..... |. ||..||||| | ..|. ||..|||| .. .. .|| | | .. |.|.|| |.. .| .. |..| QICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC-GYPP YPGLDPAGVVDLL---------------DTGGRLQCPHNTA------CSQEM .| ... . ... | |. . . | . . FP--QMQMMFKKIGSPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | AqueK253.AA | Pkinase | 160-185 | 42 | 0.00065 | 14.92 | Pfam | 190-214 (293) | Show / Hide |
Range on Protein: 160-185 Range on HMM: 190-214/293 Sequence Identity: 42% (11 aa) SEKSDVWSYGVLCWEVFSLGRTPYPG . |.|.||.|....|... ||.|.|| GPKVDMWSCGCILYEMLC-GRPPFPG |
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