Gene AqueK236 (A.queenslandica)

AqueK236

Species: A.queenslandica
Alias: AqueK236
External Links:
Annotation:

Classification

Group: STE
Family: STE20
Subfamily: PAKB

Sequence

Name Sequence Type Origin Length Description Download
AqueK236.AA Protein None 722 None Fasta, JSON
AqueK236.kin_dom Protein Kinase Domain None 247 None Fasta, JSON

Protein domain

Protein domains of AqueK236.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PBD AqueK236.AA PBD 27-60 34 2.7e-07 31.48 SMART 1-38 (38) Show / Hide 
Range on Protein: 27-60
Range on HMM: 1-38/38
Sequence Identity: 34% (13 aa)

ISEPM-GFMHCYHAE-IGS--EGFSGLPPQWKTLVDTT
|| |.  |.|  |.  .     .| |||.||..|. ..
ISTPTGNFKHIVHVGPWDGQTGEFTGLPHQWQHLLKHC
PBD AqueK236.AA PBD 26-77 21 0.00056 16.82 Pfam 1-60 (60) Show / Hide 
Range on Protein: 26-77
Range on HMM: 1-60/60
Sequence Identity: 21% (13 aa)

DISEP-MGFMHCYHAEIGS-EGFS-GLPPQWKTLVDTT-----HPSTTSPTTSRATSASP
.|| | . | |  |. . . .||  |.||.|. |....      .. .. ..  ...  .
MISTPLTNFKHTMHVGWDGQTGFFTGMPPEWQKLLQSSGISKPEQKHNPQAVFDVVQFYQ
Kinase AqueK236.AA PAKB 452-703 64 3.9e-161 541.63 In-house 1-252 (252) Show / Hide 
Range on Protein: 452-703
Range on HMM: 1-252/252
Sequence Identity: 64% (162 aa)

LDWFVKIGEGSTGTVYTAHQLSTNRVVAVKKMSLWNQQRKELLFNEVIIMKEYPHNNVVTYYDSYLVDEELWVLMEFIDGGSLTDIIRRVHLQESQIAAI
|| .|||||||||.|  | . .| |.|||||| |  ||| ||||||| || .| |.|.|  |.||||..||||.|||..||.||||.  . ..| |||..
LDNYVKIGEGSTGIVCIATEKHTGRQVAVKKMDLRKQQRRELLFNEVVIMRDYQHPNIVEMYSSYLVGDELWVVMEFMEGGALTDIVTHTRMNEEQIATV

CKSCLEALAYLHSNGVIHRDIKSDCILLMSDGTVKLSDFGYCARINQKQRRRQSLVGTPYWMAPEVISKQPYGTEVDIWSLGIMVIEMIDGQPPYFNLPA
|...|.||||||. |||||||||| ||| .||.|||||||.|| . .   .|.||||||||||||||| .||||||||||||||||||.|| ||||| | 
CRQVLQALAYLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMVDGEPPYFNEPP

SEAMNCIRTLPPPTSKSPEKISPRLRDFLSKALVYNSEERATASELLRHPFL
  ||  ||  .||  |   |.|||||.||.. || . ..|.|| ||||||||
LQAMKRIRDMHPPRLKNHHKVSPRLREFLDRMLVRDPNQRWTAQELLRHPFL
Kinase AqueK236.AA STE20 452-703 45 5.4e-141 474.71 In-house 1-288 (288) Show / Hide 
Range on Protein: 452-703
Range on HMM: 1-288/288
Sequence Identity: 45% (131 aa)

LDWFVKIGEGSTGTVYTAHQLSTNRV----VAVKKMSLWNQ----QRKELLFNEVIIMKEYPHNNVVTYYDSYLVD----EELWVLMEFIDGGSLTDIIR
 . . |||.||.|.||.|.  .|...    ||.|||.| ..    ...|....|. |||.. | |.|.||.|||.|    .|||..||. .|||||||..
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMK

RV----------HLQESQIAAICKSCLEALAYLHSNGVIHRDIKSDCILLMSDGTVKLSDFGYCARINQ-----KQRRRQSLVGTPYWMAPEVISK----
..           ..|.|||.||. .|..|.|||||..||||||.| ||| .|| |||.|||.|| ...     .|..|...||||||||||||..    
HCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCMEGP

-QPYGTEVDIWSLGIMVIEMIDGQPPYFNLPASEAMNCIR--TLPPPTSKS--PEKISPRLRDFLSKALVYNSEERATASELLRHPFL
 ..|.. .|||||||. |||..|.||||....  ||  |   . |||| |.  |.| || ..||..| |... |.|.|||.||.|||.
DKGYDYKCDIWSLGITAIEMAEGEPPYFDMHPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase AqueK236.AA PAKA 453-703 52 2.3e-136 459.33 In-house 2-260 (260) Show / Hide 
Range on Protein: 453-703
Range on HMM: 2-260/260
Sequence Identity: 52% (135 aa)

DWFVKIGEGSTGTVYTAHQLSTNRV--VAVKKMSLWNQQRKELLFNEVIIMKEYPHNNVVTYYDSYLVDEELWVLMEFIDGGSLTDIIRRVH------LQ
. . |||.|..|.||.| ...||    ||.|.| . || .|||. ||  .|||. |.|.| |.||||||.|||| ||. .||.|||.|  .       ..
KFMEKIGQGASGEVYVATNIKTNQEENVAIKQMNMKNQPKKELIINEILVMKECKHKNIVNYIDSYLVDDELWVVMEYMEGGCLTDVITQCCNIQCNYMD

ESQIAAICKSCLEALAYLHSNGVIHRDIKSDCILLMSDGTVKLSDFGYCARINQKQRRRQSLVGTPYWMAPEVISKQPYGTEVDIWSLGIMVIEMIDGQP
|.|||..|. || .| ..||...|||||||| ||| .|| ||. |||.||...|.|..|.. ||||||||||||... |.  |||||||||.||||.|.|
EGQIAYVCRECLQGLEFIHSKHRIHRDIKSDNILLGMDGSVKITDFGFCAQLTQEQQKRNTMVGTPYWMAPEVIRRKQYDEKVDIWSLGIMAIEMIEGEP

PYFNLPASEAMNCIRTLPPPTSKSPEKISPRLRDFLSKALVYNSEERATASELLRHPFL
|| | |   ||  | |   |  |.|.| |. ..|||.| |  . ..||.|.|||.||||
PYLNEPPLRAMYLIATNGKPDIKDPDKWSQEFCDFLDKCLCVDVDRRASAQELLHHPFL
Kinase AqueK236.AA STE 452-703 32 3.4e-114 385.69 In-house 1-359 (359) Show / Hide 
Range on Protein: 452-703
Range on HMM: 1-359/359
Sequence Identity: 32% (117 aa)

LDWFVKIGEGSTGTVYTAHQL------STNRV---------VAVKKMSLWNQ-----------------QRKELLFNEVIIMKEYP--HNNVVTYYDSYL
..   |||.|..||||.|         .|..|         .|.|.|.| |.                 . .. . .|. |||..   | |.|.||..|.
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

VD-------EELWVLMEFIDGGSLTDIIRRVH---------------LQESQIAAICKSCLEA-LAYLHSNGVIHRDIKSDCILLMSDGTVKLSDFGYCA
..       .|||. ||..|||||.|||....               ..|||||.||...|.. |.||||...||||||.. |||     |||.||| |.
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

RINQKQR----------------RRQSLVGTPYWMAPEVISK------QPYGTEVDIWSLGIMVIEMIDGQPPYFNLPASEAMNCIRTL-----------
..... .                .|...|||| |||||||..      ..|.| .||||||...|||..|.||.....  .||  | .            
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

----PPPTSKS-----------------PEKISPRLRDFLSKALVYNSEERATASELLR--HPFL
    |||. ..                 |.| || ..||..| |... ..|.|||.||.  |||.
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase AqueK236.AA MST 453-703 42 6.6e-95 302.1 In-house 2-254 (254) Show / Hide 
Range on Protein: 453-703
Range on HMM: 2-254/254
Sequence Identity: 42% (109 aa)

DWFVKIGEGSTGTVYTAHQLSTNRVVAVKKMSLWNQQRKELLFNEVIIMKEYPHNNVVTYYDSYL--VDEELWVLMEFIDGGSLTDIIRRVH--LQESQI
|   |.|.|| | || |  ..|. .||.|...  |    |.. .|  ||..    ..|.||.||.   ....|  ||. ..||. ||..     | | ||
DIVEKLGQGSYGSVYKAIHKQTGKIVAIKMVPV-NEDLQEII-KEISIMQQCKSKYIVKYYGSYFDAKNNHCWIVMEYCGMGSVCDIMKITQRTLNEQQI

AAICKSCLEALAYLHSNGVIHRDIKSDCILLMSDGTVKLSDFGYCARINQKQRRRQSLVGTPYWMAPEVISKQPYGTEVDIWSLGIMVIEMIDGQPPYFN
|.|... |  |.|||.|  ||||||.  |||  .|  ||.|||  .     .. |....||||||||||| .. | . .|||||||  |||  | |||..
ACILYDTLQGLQYLHDNKKIHRDIKAGNILLNHEGECKLADFGVSGQLTDTMAKRNTVIGTPYWMAPEVIQEIKYDCKADIWSLGITAIEMAEGMPPYSD

LPASEAMNCIRTLPPPTSKSPEKISPRLRDFLSKALVYNSEERATASELLRHPFL
. .. ||  | . |||| | ||. |. . ||..| |. |.|.|.|| .|| ||| 
IHPMRAMFMIPQKPPPTFKDPEQWSQEFNDFVCKCLQKNPEQRWTAEQLLQHPFI
Kinase AqueK236.AA S_TKc 452-703 30 2.9e-91 310.4 SMART 1-231 (231) Show / Hide 
Range on Protein: 452-703
Range on HMM: 1-231/231
Sequence Identity: 30% (83 aa)

LDWFVKIGEGSTGTVYTAHQLSTNRVVAVKKMSLWNQQRKELLFNEVIIMKEYPHNNVVTYYDSYLVDEELWVLMEFIDG--GSLTDIIRRVH-------
 .   |||.|. |.|| ..  .|.|.||.|...       | . .|. |.|.  | |.|..||..   ..|.. ||..||  |.| |.|..         
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

LQESQIAAICKSCLEALAYLHSNGVIHRDIKSDCILLMSDGTVKLSDFGYCARINQKQRRRQSLVGTPYWMAPEVISKQPYGT-EVDIWSLGIMVIEMID
. | ... ...  ..||.|.||.|.||||.| . ||| .  ..|..||| ....        ...|||..|||||.   .||. ..|.||.|....||. 
FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC

GQPPYFNLPASEAMNCIRTLPPPTSKSPEKISPRLRDFLSKALVYNSEERATASELLR-------HPFL
|.||.      . .. |.             || ..||..| |... |.| || |.|.       ||..
GYPPFP--QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase AqueK236.AA Pkinase 452-703 29 1.3e-84 292.15 Pfam 1-293 (293) Show / Hide 
Range on Protein: 452-703
Range on HMM: 1-293/293
Sequence Identity: 29% (86 aa)

LDWFVKIGEGSTGTVYTAHQLSTNRVVAVKKMSLWNQQRKEL--LFN--EVIIMKEYPHNNVVTYYDSYLVDEELWVLMEFIDGG----SLTDIIR---R
.    |||.|| |.|| .|  .|...||||.... ..  ...  ...  |. |||.  | |.|..||..  . .... ||. .||    .| |.|.   .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

VHL--QESQIAAICKSCLEALAYLHSNGVIHRDIKSDCILLMSDGTV----KLSDFGYCARI-NQKQRRRQSLVGTPYWMAPEVIS-KQPYGTEVDIWSL
  .  .| ..  ...  |..|.|.||.|.||||.|.. ||. ..|..    |..||| .. . . ...  ....|||..||||||   |.||..||.||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GIMVIEMIDGQPPYFNL-----PASEAMNCIRTLPPPTSKSPEKIS-------------------PRLRDFLSKALVYNSEERATASELLRHPFL
|....||. |.||. .          .| | .  ||. . .|...|                   . ..||... | .. ..| || ..| ||..
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase AqueK236.AA YSK 455-703 39 7.3e-83 249.27 In-house 1-257 (257) Show / Hide 
Range on Protein: 455-703
Range on HMM: 1-257/257
Sequence Identity: 39% (101 aa)

FVK---IGEGSTGTVYTAHQLSTNRVVAVKKMSLWNQQRK-ELLFNEVIIMKEYPHNNVVTYYDSYLVDEELWVLMEFIDGGSLTDIIRR---VHLQESQ
|.|   || || | || .    |.||||.|   |       |..  |. .  .    ..  || ||| |  ||. ||.  |||. | ...     ..|..
FTKQECIGRGSFGEVYKGIDNRTQRVVAIKIIDLEHAEDEIEDIQQEIQFLSQCDSPYITKYYGSYLKDTKLWIIMEYCGGGSCLDLMKPKYVGQFDEKY

IAAICKSCLEALAYLHSNGVIHRDIKSDCILLMSDGTVKLSDFGYCARINQKQRRRQSLVGTPYWMAPEVISK--QPYGTEVDIWSLGIMVIEMIDGQPP
|| | .  | .| ||||. .||||||.  .||  .| ||| |||  ..|.. | .|.  |||||||||||| .    | . .|||||||  .||  |.||
IAIILREILKGLDYLHSERKIHRDIKAANVLLSEHGDVKLCDFGVAGQITDTQIKRNTFVGTPYWMAPEVICQEVSYYDFKADIWSLGITAYEMAKGEPP

YFNLPASEAMNCIRTLPPPTSKSPEKISPRLRDFLSKALVYNSEERATASELLRHPFL
|  . .  .|  |   .||. .  .. |  . .|    |... |.| .|.||| | | 
YCDYHPMRVMFLIPKNNPPKLEG-RSYSKMFKEFVECCLNKDPEQRPSAKELLKHKFI
Kinase AqueK236.AA STE11 457-703 34 2.6e-81 276.43 In-house 6-303 (303) Show / Hide 
Range on Protein: 457-703
Range on HMM: 6-303/303
Sequence Identity: 34% (102 aa)

KIGEGSTGTVYTAHQLSTNRVVAVKKMSLWNQQ----------RK----ELLFNEVIIMKEYPHNNVVTYYDSYLV---DEELWVLMEFIDGGSLTDIIR
.||.|. ||||... ..|....|||.. . |.           ..    ...  |. .||   |.| | ||.. |    .... . ||.. |||| ...|
IIGKGAFGTVYKCMNVDTGELMAVKQIEIQNNNQMKEDQEKEYQSHKMHKAIQEEIKLMKHLNHKNIVRYYGCCLHDNQNDHVNIFMEYCPGGSLSSMLR

-R---VHLQESQIAAICKSCLEALAYLHSNGVIHRDIKSDCILLMSDGT-VKLSDFGYCARINQKQRRRQS----------LVGTPY--------WMAPE
 .     ..|. |    |  ||.|.||||.|.|||||| . |||.|||. .||.||| . |...  .. ..          . ||||        |||||
HKWGPMKFDEMVIRKYTKQILEGLQYLHSHGIIHRDIKGANILLDSDGNVCKLADFGCAKRLAWICTCTHNMNMTQNHCKSMTGTPYNSMMGTPMWMAPE

VISKQP---YGTEVDIWSLGIMVIEMIDGQPPYFNL---PASEAMNCI--RTLPPP--TSKSPEKIS---PRLRDFLSKALVYNSEERATASELLRHPFL
||....   ||. .||||||  ||||. |.||. |.   .. . . ..  .. .||   . ||  ||   . .||||.. .... ..|.||..||.|||.
VIKQEGRDGYGRKADIWSLGCTVIEMATGKPPWHNYDHNHMAAMFKIGMGHKPHPPIPEHMSP--ISWISEECRDFLRHCFEHDPKKRPTANQLLQHPFI
Kinase AqueK236.AA KHS 453-703 40 3.6e-74 248.84 In-house 2-258 (258) Show / Hide 
Range on Protein: 453-703
Range on HMM: 2-258/258
Sequence Identity: 40% (103 aa)

DWFVKIGEGSTGTVYTAHQLSTNRVVAVKKMSLWNQQRKELLFNEVIIMKEYPHNNVVTYYDSYLVDEELWVLMEFIDGGSLTDIIRRV-HLQESQIAAI
.   ..| |  | || |..  .. ..||| . .  ..  ...  |...||.  | |.| |. |||  . ||. ||.  |||| || .   .|.| ||| .
ELLQRVGSGTYGDVYKARDIQSDELAAVKVIKMEPGDDFAVIQQEIMMMKDCRHPNIVAYFGSYLRRDKLWICMEYCGGGSLQDIYHVTGPLSELQIAYV

CKSCLEALAYLHSNGVIHRDIKSDCILLMSDGTVKLSDFGYCARINQKQRRRQSLVGTPYWMAPEVIS---KQPYGTEVDIWSLGIMVIEMIDGQPPYFN
|.  |..|.||||.| .|||||   ||| ..| ||| |||  |.| .   .|.| .|||||||||| .   |  |.   |||..||  ||. . ||| |.
CRETLQGLHYLHSMGKMHRDIKGANILLTDQGDVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNQLCDIWAVGITAIELAELQPPMFD

LPASEAMNCIR--TLPPPTSKSPEKISPRLRDFLSKALVYNSEERATASELLRHPFL
|    |.  .      ||. |  .| |.   .|.  ||. |.  | ||. ||.|||.
LHPMRALFLMTKSNFQPPKLKDKHKWSQTFHHFVKMALTKNPKKRPTAEKLLQHPFV
Kinase AqueK236.AA PAKL 457-703 39 2e-72 246.91 In-house 6-256 (256) Show / Hide 
Range on Protein: 457-703
Range on HMM: 6-256/256
Sequence Identity: 39% (100 aa)

KIGEGSTGTVYTAHQLSTNRVVAVKKMSLWNQQRKELLFNEVIIMKEYPHNNVVTYYDSYLVD-EELWVLMEFIDGGSLTDIIRRVH--LQESQIAAICK
| |.|| |.|| |   .|| . |.| ...    . . . .|. | |     |.| |. |      ..|.||..   ||  |..  .   |.| ||. | .
KLGQGSYGSVYKAIHKDTNFPLAIKVIEIKESNEIKDIEKEIQILKKCKCPNIVSYFGSIQQKLNHYWILMDYCSLGSINDMMESCCKTLNEKQISVILQ

SCLEALAYLHSNGVIHRDIKSDCILLMSDGTVKLSDFGYCARINQKQR-RRQSLVGTPYWMAPEVISKQPYGTEVDIWSLGIMVIEMIDGQPPYFNLPAS
  |  | |||| ..||||||.  |||  |. ||. |||   ...   .    ...|||||||||.| ||.|   .||||||| .||| || ||   .|  
QTLKGLHYLHSKNIIHRDIKAANILLNEDCQVKIADFGVSQQLQDEYDGQANQMIGTPYWMAPEIINKQNYNNKCDIWSLGITAIEMADGFPPHYDMPPM

EAMNCIRTLPPPTSKSPEKISPRLRDFLSKALVYNSEERATASELLRHPFL
 ||  |   |||| . | . || . ||| . .|   |.|. ...|| |||.
RAMYMIPNWPPPTFSNPKHWSPCFNDFLAQCCVKDPEKRWSPIDLLCHPFI
Kinase AqueK236.AA SLK 453-703 37 6.4e-71 238.46 In-house 2-259 (259) Show / Hide 
Range on Protein: 453-703
Range on HMM: 2-259/259
Sequence Identity: 37% (97 aa)

DWFVKIGEGSTGTVYTAHQLSTNRVVAVKKMSLWNQQRKELLFNEVIIMKEYPHNNVVTYYDSYLVDEELWVLMEFIDGGSLTDIIRRVH--LQESQIAA
.    .|.|  | || |..  .... | | . . ..   |  . |. |. |  | |.|  |..| .|..||...|| ||| .  |.  ..  |.|.||. 
EIIGELGDGAFGKVYKAQHKEQKVFAAAKMIEIKDEEELEDYMVEIDILSECKHPNIVKLYEAYYYDNKLWMMIEFCDGGAVDNIMVELEHPLTEDQIQY

ICKSCLEALAYLHSNGVIHRDIKSDCILLMSDGTVKLSDFGYCARINQKQRRRQSLVGTPYWMAPEVI-----SKQPYGTEVDIWSLGIMVIEMIDGQPP
.||  .||| .|||| |||||.|   ||.  || |.| |||  |.  .. ..| . .||||||||||.       |||   .||||||| .||| .. ||
VCKHMCEALNWLHSNKVIHRDLKAGNILMTMDGDVRLADFGVSAKNKHTMQKRDTFIGTPYWMAPEVVMCETFKDQPYDYKADIWSLGITLIEMAQMEPP

YFNLPASEAMNCIRTLPPPTSKSPEKISPRLRDFLSKALVYNSEERATASELLRHPFL
. ..     .  |.   ||| . | . |   .||| |.|| . . | |...|..|...
HHEMNPMRVLLKIQKSEPPTLEQPSHWSKEFKDFLKKCLVKDPQNRWTTAQLMQHQWV
Kinase AqueK236.AA Pkinase_Tyr 457-659 28 2.2e-22 76.4 Pfam 6-230 (270) Show / Hide 
Range on Protein: 457-659
Range on HMM: 6-230/270
Sequence Identity: 28% (64 aa)

KIGEGSTGTVYTAHQL----STNRVVAVKKM--SLWNQQ--RKELLFNEVIIMKEY-PHNNVVTYYDSYL-VDEE--LWVLMEFIDGGSLTDIIRRV---
|.|||. |.|| ..      .|.  ||||..  .   .|  |....  |. |||..  | |.| .|   .  .|   ... ||.  .|.| |  |.    
KLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMR-EAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHRED

--HLQESQIAAICKSCLEALAYLHSNGVIHRDIKSDCILLMSDGTVKLSDFGYCARI--NQKQ-RRRQSLVGTPYWMAPEVISKQPYGTEVDIWSLGIMV
  .|  ...  .|    ....||.|.. ||||.    .|. ....|| .||| .  |       | |..      |||||.|.   . |. |.|| |.  
KQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLM

IEMID-GQPP-YFNLPASEAMNCI-R
 |..  |. | | ... .| .. | .
WEIFTYGEQPTYPGMSNEEVYEYIYE
Kinase AqueK236.AA TyrKc 457-703 25 9.6e-18 64.2 SMART 6-280 (280) Show / Hide 
Range on Protein: 457-703
Range on HMM: 6-280/280
Sequence Identity: 25% (73 aa)

KIGEGSTGTVYTAHQLSTNRVVAVKKMSLWNQQRKELLFNEVIIMKEY--PHNNVVTYYDSYLVD-------EELWVLMEFIDGGSLTDIIRRVH--LQE
|.|||  |.|| ..     . ||||..       .| . .|  ||...   | |.|  |   . .       | |...||. ..|.| | .|. .  |. 
KLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCM

SQIAAICKSCLEALAYLHSNGVIHRDIKSDCILLMSDGTVKLSDFGYCARINQK-------QRRRQSL-VGTP-----YWMAPEVISKQPYGTEVDIWSL
..   .|    .  .||||...||||.    .|. ...||| |||| .  |  .       .  |..   |.       |||||.| .  . |. |.|| 
KDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSF

GIMVIEMI-DGQPPYFN-----LPASEAMNCIRTL---PPPTSKSPEKI-----SPRLRDFLSKALVYNSEERATASELLRHPFL
|..  |.  .||.|| .     ....|.......    |.| .   . .     .. . .  ..   .. |.| | ||.  | ..
GVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-P-MSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF