Gene AqueK124 (A.queenslandica)

AqueK124

Species: A.queenslandica
Alias: AqueK124
External Links:
Annotation:

Classification

Group: CMGC
Family: MAPK
Subfamily: ERK7

Sequence

Name Sequence Type Origin Length Description Download
AqueK124.AA Protein None 492 None Fasta, JSON
AqueK124.kin_dom Protein Kinase Domain None 149 None Fasta, JSON

Protein domain

Protein domains of AqueK124.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK124.AA ERK7 5-231 53 4.5e-109 368.65 In-house 84-292 (292) Show / Hide 
Range on Protein: 5-231
Range on HMM: 84-292/292
Sequence Identity: 53% (121 aa)

DTDLHAVIK-SKIL*SVHMQYIMSQLCRVFMYMYMYMYTWYIHSGNVIHRDLKPSNILINSECFIKLADFGLAHSLASTSNEGSKGVGGDGVSDFNPAMT
.|||||||.  .||  .| |||| || |   ||         ||||||||||||||||..|||..|..||||| |.|.. .           .. ||..|
ETDLHAVIRKGNILKDIHKQYIMYQLLRAIKYM---------HSGNVIHRDLKPSNILLDSECMVKVCDFGLARSIAQQEEY----------DEQNPMLT

DYVATHWYRSPEILLGSRRYTRGVDMWSLGCILAEMIASKPLYPGSSTINQLDRIMSTLPPPSRQDMESIKSPYAKAILDQIIHKRHKYLTDILPQADDI
.|||| |||.|||||||.|||.||||||.||||.||.  ||..||.||.||...|. |.| |...|.|.|.| ||  .|.|......| | ...||. | 
EYVATRWYRAPEILLGSHRYTKGVDMWSIGCILGEMLRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMPQCCDD

SLDLLNKLLNFNPNKRLTAENCLEHPYL
 .||| .|| |||.||||||..|.||| 
AIDLLKRLLVFNPKKRLTAEQALQHPYV
Kinase AqueK124.AA MAPK 3-231 41 1.5e-93 317.14 In-house 97-328 (328) Show / Hide 
Range on Protein: 3-231
Range on HMM: 97-328/328
Sequence Identity: 41% (101 aa)

LIDTDLHAVIKSKI-L*SVHMQYIMSQLCRVFMYMYMYMYTWYIHSGNVIHRDLKPSNILINSECFIKLADFGLAHSLASTSNEGSKGVGGDGVSDFNP-
| .||||..|||   |   |.||.| |..|            ||||.|||||||||||||.|..|  |..||||| |.......  . . .  .. |   
LMETDLHQIIKSQQPLSDDHIQYFMYQILRGLK-------LKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDP--HC-F-QK

-AMTDYVATHWYRSPEILLG--SRRYTRGVDMWSLGCILAEMIA-SKPLYPGSSTINQLDRIMSTLPPPSRQDMESIK-SPYAKAILDQI---IHKRHKY
  ||.|||| |||.|||.|.  ...|| .|||||.|||.|||.   ||| ||...|.|. .||..|. ||..... |. |. |.  . .     ..  | 
MHMTEYVATRWYRAPEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKP

LTDILPQ----ADDISLDLLNKLLNFNPNKRLTAENCLEHPYL
.....|     |..  .||| |.| |.|.||.|.| .|.|||.
WEKMFPNANFNANPQAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase AqueK124.AA ERK 3-231 42 6.5e-77 261.84 In-house 90-307 (307) Show / Hide 
Range on Protein: 3-231
Range on HMM: 90-307/307
Sequence Identity: 42% (99 aa)

LIDTDLHAVIKSK-IL*SVHMQYIMSQLCRVFMYMYMYMYTWYIHSGNVIHRDLKPSNILINSECFIKLADFGLAHSLASTSNEGSKGVGGDGVSDFNPA
|..|||| .|.|.  |   | || | |. .            |||| |||||||||||||.|| |  | .|||||  ......|...          .. 
LMETDLHQIINSQQELSDDHCQYFMYQILCG---------LKYIHSANVIHRDLKPSNILVNSNCDLKICDFGLARCFDASYQENHE--------CNQNF

MTDYVATHWYRSPEILLGSRRYTRGVDMWSLGCILAEMIASKPLYPGSSTINQLDRIMSTLPPP-SRQDMESIKSPYAKAILDQIIH--KRHKYLTDILP
||.|||| |||.|||.|  . ||. .|.|| |||.|||.. ||| || ....|..|| ...  | | .|.. |.|. |.  . .  .  .  | . .| |
MTEYVATRWYRAPEIMLSWQKYTKAMDIWSCGCIFAEMLGRKPLFPGKDYVHQINRIFQIIGTPHSEEDLQYICSENAWKYIKNLPNPVRPPKPWENIFP

QAD--DISLDLLNKLLNFNPNKRLTAENCLEHPYL
 |.     .||| |.| |.|.||.|.| ||||||.
NANCNPQAIDLLEKMLVFDPDKRITVEECLEHPYF
Kinase AqueK124.AA CMGC 44-231 25 1.3e-74 244.33 In-house 197-513 (513) Show / Hide 
Range on Protein: 44-231
Range on HMM: 197-513/513
Sequence Identity: 25% (83 aa)

YIHSGN--VIHRDLKPSNILINSECF--------------------IKLADFGLAHSLASTSNEGSKGVGGDGVSDF---------NPAMTDYVATHWYR
|.|| .  .|||||||.|||||..|                     .|..||||| .. . |..  . ..      |         | ..|.||.| |||
YCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQS----FKNVNKDDKPNRPYTHYVVTRWYR

SPEILLGSRRYT---------RGVDMWSLGCILAEMIAS--------KPLYP-----------GSSTINQLDRIMSTLPPP----------------SRQ
.||||||...||          ..||||.|||.|||.          ||| |           |.|.|.||..|. .| .|                ...
APEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEE

DMESIKSPYAKA------------ILDQ-----------IIHKRHKYLTDILPQ-----------------------------------ADDISLDLLNK
... || |. .             ...               .. | .... |                                    .|.  .|||.|
WPNMIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKK

LLNFNPNKRLTAENCLEHPYL
.| ..|.||.||| .|.|||.
MLQYDPDKRITAEQALQHPYF
Kinase AqueK124.AA p38 3-231 35 3.1e-66 225.32 In-house 89-289 (289) Show / Hide 
Range on Protein: 3-231
Range on HMM: 89-289/289
Sequence Identity: 35% (82 aa)

LIDTDLHAVIKSKIL*SVHMQYIMSQLCRVFMYMYMYMYTWYIHSGNVIHRDLKPSNILINSECFIKLADFGLAHSLASTSNEGSKGVGGDGVSDFNPAM
. ..||. ..|.. |   | |..  |. |            |||| ..|||||||||| .| .| ..  |||||                         |
FMGADLNNIMKCQRLSDDHIQFLVYQILRGLK---------YIHSAGIIHRDLKPSNIAVNEDCELRILDFGLAR-------------------HCDDEM

TDYVATHWYRSPEILLGSRRYTRGVDMWSLGCILAEMIASKPLYPGSSTINQLDRIMSTLPPPSRQDMESIKSPYAKAILDQIIHKRHKYLTDILPQADD
|.|||| |||.|||.|   .||  ||.||.|||.||.|  ..|.||.  |.|| |||. .  |..  .. |.|  |.. .  .     . .......|. 
TGYVATRWYRAPEIMLNWMHYTQTVDIWSVGCIMAELITGRTLFPGDDHIDQLQRIMKVCGTPDEEFWQKIQSEEARNYIQSYPQMPRRDFHHVFMGANP

ISLDLLNKLLNFNPNKRLTAENCLEHPYL
  .||| |.|   | ||.|||  ..|||.
QAIDLLEKMLELDPDKRITAEEAMQHPYF
Kinase AqueK124.AA CDK 44-231 36 6.3e-65 206.6 In-house 123-284 (284) Show / Hide 
Range on Protein: 44-231
Range on HMM: 123-284/284
Sequence Identity: 36% (72 aa)

YIHSGNVIHRDLKPSNILINSECF-----IKLADFGLAHSLASTSNEGSKGVGGDGVSDFNPAMTDYVATHWYRSPEILLGSRRYT--RGVDMWSLGCIL
|.|| ...||||||.|||||.        .|.||||||    . ..         .  . | ..|  | | |||.||.||||..|.   ..||||.|||.
YCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQ---------MS-EPNRTYTHEVVTLWYRAPELLLGSKHYSGGTPIDMWSVGCIF

AEMIA---SKPLYPGSSTINQLDRIMSTLPPPSRQDMESIKS-PYAKAILDQIIHKRHKYLTDILPQADDISLDLLNKLLNFNPNKRLTAENCLEHPYL
|||.     ||| ||.| |.||..|  ..  |. ..  .... |.                            |||||.| ..|.||..|| .|.|||.
AEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY---------------------------DLLNKMLCYDPKKRISAEQALQHPYF
Kinase AqueK124.AA ERK1 2-231 42 3.2e-63 216.36 In-house 82-289 (289) Show / Hide 
Range on Protein: 2-231
Range on HMM: 82-289/289
Sequence Identity: 42% (97 aa)

SLIDTDLHAVIKSKIL*SVHMQYIMSQLCRVFMYMYMYMYTWYIHSGNVIHRDLKPSNILINSECFIKLADFGLAHSLASTSNEGSKGVGGDGVSDFNPA
.|..|||  ..|.. |   |. | . |. |            |||| ||.||||||||.|.|  | .|. |||||  .|            |   |    
CLMETDLYKLLKTQHLSNDHICYFLYQILRGLK---------YIHSANVLHRDLKPSNLLLNTTCDLKICDFGLAR-IA------------DPEHDHTGF

MTDYVATHWYRSPEILLGSRRYTRGVDMWSLGCILAEMIASKPLYPGSSTINQLDRIMSTLPPPSRQDMESIKSPYAKAILDQIIHKRHKYLTDILPQAD
.|.|||| ||| |||.| |. ||. .|.|| |||||||.. .|..||   . ||  |.. |  ||..|.. |    |.. |  . || .  .  . |.||
LTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGVLGSPSQDDLNCIINEKARNYLQSLPHKPKVPWARLFPKAD

DISLDLLNKLLNFNPNKRLTAENCLEHPYL
   ||||.|.| |||.||.| |. | ||||
SKALDLLDKMLTFNPHKRITVEEALAHPYL
Kinase AqueK124.AA ERK5 3-231 36 5.6e-57 195.62 In-house 85-295 (295) Show / Hide 
Range on Protein: 3-231
Range on HMM: 85-295/295
Sequence Identity: 36% (84 aa)

LIDTDLHAVIKSKIL*SV-HMQYIMSQLCRVFMYMYMYMYTWYIHSGNVIHRDLKPSNILINSECFIKLADFGLAHSLASTSNEGSKGVGGDGVSDFNPA
|.. ||| .| |    .. |. | . |. |   ||         || .||||||||||.|.|  | .|. |||.|  |.  | .  .             
LMESDLHQIIHSNQPFTLEHIRYFLYQILRGLKYM---------HSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTFSPDKHQMF-----------

MTDYVATHWYRSPEILLGSRRYTRGVDMWSLGCILAEMIASKPLYPGSSTINQLDRIMSTLPPPSRQDMESIKSPYAKAILDQ-IIHKRHKYLTDILPQA
||.|||| ||| ||... |  ||  .|.|| |||. |||| . ..||   |.||. ||  |  |. . .... .   .. . . .  .. | .  . |.|
MTEYVATRWYRAPELMFSSHDYTQAIDVWSVGCIFGEMIARRQMFPGKNYIHQLQLIMMVLGMPPPHMIQAVSADHVYNYFQKNFPNRQPKDWEKVYPKA

DDISLDLLNKLLNFNPNKRLTAENCLEHPYL
|  .|||| ..| | | .|.|.   | ||.|
DRQALDLLARMLRFEPSERITVNKALQHPFL
Kinase AqueK124.AA Pkinase 44-231 30 2.5e-52 184.97 Pfam 123-293 (293) Show / Hide 
Range on Protein: 44-231
Range on HMM: 123-293/293
Sequence Identity: 30% (61 aa)

YIHSGNVIHRDLKPSNILINSECFI----KLADFGLAHSLASTSNEGSKGVGGDGVSDFNPAMTDYVATHWYRSPEILLGSRRYTRGVDMWSLGCILAEM
|.|| ..|||||||.||||.... |    |..|||||  .                   |. ||... | ||..||...|.. |.. |||||.||||.||
YCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD---------------Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEM

IASKPLYPGS----STINQLDRIMSTLP-PPSRQDMESIKSPYAKAILDQIIHKRHKYLTDILPQADDISLDLLNKLLNFNPNKRLTAENCLEHPYL
.  .|..||.    . ..|. .|  ... |....  ...  .| . . .   |   . ..   . ...  .|.....|...|.||.||| .|.||..
LCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H---F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase AqueK124.AA CDK5 106-231 39 6.6e-43 133.1 In-house 159-287 (287) Show / Hide 
Range on Protein: 106-231
Range on HMM: 159-287/287
Sequence Identity: 39% (51 aa)

VATHWYRSPEILLGSRRYTRGVDMWSLGCILAEMI-ASKPLYPGSSTINQLDRIMSTLPPPSRQDMESIK--SPYAKAILDQIIHKRHKYLTDILPQADD
| | ||| | .|.||. |.  .|||| |||.|||. | .||.||... .|| ||   .  |.     ||   . |   . .  ..  |. .  | |. | 
VVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAEMANAGRPLFPGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPKLDE

ISLDLLNKLLNFNPNKRLTAENCLEHPYL
  .|||.|.| .|||.|..|.. |.||| 
KGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase AqueK124.AA MAPK-Unclassified 102-231 30 4.7e-37 129.43 In-house 405-575 (575) Show / Hide 
Range on Protein: 102-231
Range on HMM: 405-575/575
Sequence Identity: 30% (52 aa)

MTDYVATHWYRSPEILLGSRRYTRGVDMWSLGCILAEMIAS-----------KPLYPGSS--------------------TINQLDRIMSTLPPPSRQDM
|| ||.| ||| |||.| .  |.  ||.||.|||.|||.             .|| ||..                     . |.  | . |  |  .|.
MTQYVVTRWYRAPEIMLSMHEYDTQVDIWSIGCIFAEMMQMYDRHNPTFSDHRPLFPGQDCFPITPDRNNDVDQGGFPHSHQDQIKMIFDYLGMPPEEDC

ESIKSPYAKAILDQIIHKRHKYLTDILPQADD----------ISLDLLNKLLNFNPNKRLTAENCLEHPYL
  |... |.  .     |     ||. . .              .|...|.| |||.|| ||.  ||||| 
NFITCDSARKYIQSFKCKTPVHFTDLMFCKAPGDDQIVRGNCECIDFVQKMLQFNPWKRITADQALEHPYF
Kinase AqueK124.AA S_TKc 4-231 20 9.9e-21 76.11 SMART 19-231 (231) Show / Hide 
Range on Protein: 4-231
Range on HMM: 19-231/231
Sequence Identity: 20% (59 aa)

IDTD------------------------------LHAVIKSKIL*SVHMQYIMSQLCRVFMYMYMYMYTW---------------------YIHSGNVIH
....                              |. |. .     . | |.   |  .| |.  . .                       |.|| ..||
RHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPEHARFYMYQICCALEYCHSHGIIH

RDLKPSNILINSECFIKLADFGLAHSLASTSNEGSKGVGGDGVSDFNPAMTDYVATHWYRSPEILLGSRRYTR-GVDMWSLGCILAEMIASKPLYPGSST
|||||.|||...   ||..|||||  |                       | .. | ||..||.|     |..  .|.||.||||.||.. .|..|    
RDLKPENILLDE--HIKICDFGLARQL-----------------------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEMLCGYPPFP--QM

INQLDRIMSTLPPPSRQDMESIKSPYAKAILDQIIHKRHKYLTDILPQADDISLDLLNKLLNFNPNKRLTAENCLE-------HPYL
   ...|.                                         ..  .|...|.|...|.||.||  .|.       ||..
QMMFKKIG-----------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase AqueK124.AA MAPK-Unclassified 3-78 39 1.1e-17 60.12 In-house 87-158 (575) Show / Hide 
Range on Protein: 3-78
Range on HMM: 87-158/575
Sequence Identity: 39% (32 aa)

LIDT---DLHAVIKSKI--L*SVHMQYIMSQLCRVFMYMYMYMYTWYIHSGNVIHRDLKPSNILINSECFIKLADFGLAHS
.  |   ||| .||| .  .   | ||.. |. |            |.|| ..|||||||||.|||  | .. .|||.. |
YMQTSLFDLHQIIKSNQDHWCHQHIQYFFYQILRGLK---------YLHSACIIHRDLKPSNLLINQDCSVRICDFGMSRS
Kinase AqueK124.AA CDK5 46-76 64 2.2e-15 44.58 In-house 115-145 (287) Show / Hide 
Range on Protein: 46-76
Range on HMM: 115-145/287
Sequence Identity: 64% (20 aa)

HSGNVIHRDLKPSNILINSECFIKLADFGLA
|. .| |||||| | ||| ..  ||||||||
HEHHVLHRDLKPQNLLINKNGELKLADFGLA
Kinase AqueK124.AA TyrKc 11-231 14 2.5e-05 -136.37 SMART 1-280 (280) Show / Hide 
Range on Protein: 11-231
Range on HMM: 1-280/280
Sequence Identity: 14% (46 aa)

VIKSKIL*S-----VH------------MQ-----------YIMSQL-------------CRVF-------MYMYMYM-------------YTW------
. . |.| .     |.            ..            ||..|             |.           ... |             ..       
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMK

--------------YIHSGNVIHRDLKPSNILINSECFIKLADFGLAHSLASTSNEGSKGVGGDGVSDFNPA----MTDY-VATHWYRSPEILLGSRRYT
              |.|| |.|||||   |.|....  .| .||||.  . .  ..|         .|   .     ... .   |. .|| .   ...|
DLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG-------ESKDYYRKKEHKGGKTMLPIRWM-APECI-NYGKFT

RGVDMWSLGCILAEMIAS-KPLYPG--------SSTINQLDRIMSTLPPPS----RQDMESIKSPYAKAILDQIIHKRHKYLTDILPQADDISLDLLNKL
   | || |  . |.    .. |||        .  |..... .   .||.                                   . . |   ..  . 
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS----------------------------F-VCCPDEMYQIMKQC

LNFNPNKRLTAENCLEHPYL
 ...|..| | ...  | ..
WHEDPEDRPTFSEI--HECF
Kinase AqueK124.AA Pkinase_Tyr 44-76 48 7.6e-05 17.04 Pfam 126-158 (270) Show / Hide 
Range on Protein: 44-76
Range on HMM: 126-158/270
Sequence Identity: 48% (16 aa)

YIHSGNVIHRDLKPSNILINSECFIKLADFGLA
| .| | |||||   |.|.... ..| .|||||
YLESKNCIHRDLAARNCLVTENNVVKICDFGLA
Kinase AqueK124.AA CMGC 3-36 21 0.057266 1.21 In-house 136-188 (513) Show / Hide 
Range on Protein: 3-36
Range on HMM: 136-188/513
Sequence Identity: 21% (12 aa)

LIDTDLHAVIKS----------KIL*SVH------------MQYIMSQLCRVFMYM
..|.||. .||.          . |   |             .|.|  ..| .||.
YMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMI-HIR-YMYQ