Gene AqueK100 (A.queenslandica)
AqueK100
Species: A.queenslandica
Alias: AqueK100
External Links:
Annotation:
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| AqueK100.AA | Protein | None | 288 | None | Fasta, JSON |
| AqueK100.kin_dom | Protein Kinase Domain | None | 221 | None | Fasta, JSON |
Protein domains of AqueK100.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | AqueK100.AA | CDK9 | 11-234 | 55 | 5.70000000001e-144 | 484.6 | In-house | 82-340 (340) | Show / Hide |
Range on Protein: 11-234 Range on HMM: 82-340/340 Sequence Identity: 55% (145 aa) ATPYNRDKG--SIYLVLDFCEHDLAGLLECKEIKFSLSEIKNIMQQLFNALAYIHGNNILHRDMKSCNILVTRKGELKLADFGLARALNKGTNQ---R-- ||.||| |. ..|||.||||||||||| ..||||..|| .||.| | | ||| | ||||||| |.|.|. | ||||||||||| |. | ATAYNRYKDRATFYLVFDFCEHDLAGLLSNMNVKFSLGHIKKMMQHLMNGLYYIHRNKILHRDMKAANVLITKDGILKLADFGLARAFSQPKNDAPNRPL YTNRVVTLWYRPPELFLGERNYGPPIDMWGAGCIMAEMWTRRPIMQGDTEQKQITLICQLCGSISPTEWAGVEKLEYYQKL------ELPQKENRKLKER ||||||||||||||| ||.|||||||||||||||||||||| |||||.|||.| .|| |||||| | | ..|..| ..|. |||. ||.|.| YTNRVVTLWYRPPELLLGDRNYGPPIDMWGAGCIMAEMWTRSPIMQGNTEQHQLQLISQLCGSITPDVWPNCENMELWNKMSSEPNSELPKGQKRKVKDR LRHFVE----------------------DPYALDLIDKLLMLDPRKRIDADSTLEHDFF .. .. |..|..|||||| .|| ||.|.| |.||.| MKNYMKFDAPDSKTDPFGKNVKQHDSATDQQACHLIDKLLNIDPKKRMDSDEALDHDWF |
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| Kinase | AqueK100.AA | CDK | 16-234 | 38 | 6.1e-105 | 336.7 | In-house | 86-284 (284) | Show / Hide |
Range on Protein: 16-234
Range on HMM: 86-284/284
Sequence Identity: 38% (92 aa)
RDK--GSIYLVLDFCEHDLAGLLECKEIKFSLSEIKNIMQQLFNALAYIHGNNILHRDMKSCNILVTRKGE-----LKLADFGLARALNK-----GTNQR
.|| ..|.| ....|||..... ||..|.|| ..|.|.| |.|.|||.| |||....|| ||.|||||||| . . |.
KDKHENKLYMVFEYMDHDLKKYMD----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRT
YTNRVVTLWYRPPELFLGERNYG--PPIDMWGAGCIMAEMWT---RRPIMQGDTEQKQITLICQLCGSISPTEWAGVEKLEYYQKLELPQKENRKLKERL
||..|||||||.||| ||...|. .|||||..|||.|||.| |.|...||.|. |. .|...||. .. | ||.|| .|
YTHEVVTLWYRAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY-----------------
RHFVEDPYALDLIDKLLMLDPRKRIDADSTLEHDFF
||..|.|..|| ||| |. |.|..|
----------DLLNKMLCYDPKKRISAEQALQHPYF
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| Kinase | AqueK100.AA | CRK7 | 10-234 | 40 | 5.1e-93 | 315.33 | In-house | 75-343 (343) | Show / Hide |
Range on Protein: 10-234 Range on HMM: 75-343/343 Sequence Identity: 40% (108 aa) SATPYNRDKGSIYLVLDFCEHDLAGLLECKEIK-FSLSEIKNIMQQLFNALAYIHGNNILHRDMKSCNILVTRKGELKLADFGLARALNKGT-NQRYTNR .| ...|||.|.| . |||.|||| ||.. ||....| .| || ..|.| .|.|||| | |||. .||.|.||||||| .|. . |||| DASEFKKHKGSFYMVFEYMDHDLMGLLESKEMHHFSHQQCKCFMKQLLEGMDYCHKKNFLHRDIKCSNILMNNQGEVKIADFGLARLYNSEEKRRPYTNR VVTLWYRPPELFLGERNY--------------------------------------GPPIDMWGAGCIMAEMWTRRPIMQGDTEQKQITLICQLCGSISP |.||||||||| ||| .| || ||||. |||..| |..|| || | .|. .| ..||| | VITLWYRPPELLLGEERYTEQHILKELIRNIKSIQLSLLISIYLKLTVQSSIFKKSGPEIDMWSCGCILGELFTKKPIFQGNNEMAQLEKIYKICGSPNP TEWAGVEKLEYYQKLELPQKENRKLKERLRH----FVEDPYALDLIDKLLMLDPRKRIDADSTLEHDFF | | || ... . .. ||.| | | .. .||| ||.| ||| ||. | .|.||.| NNWPEVMKLPWWNTMKPKRQYNRRLREEFYHHKKPVFMPKECLDLLDKMLCLDPKKRFTAEECLQHDWF |
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| Kinase | AqueK100.AA | CMGC | 16-234 | 21 | 1.4e-92 | 304.55 | In-house | 108-513 (513) | Show / Hide |
Range on Protein: 16-234
Range on HMM: 108-513/513
Sequence Identity: 21% (87 aa)
RDKG-----------------SIYLVLDFCEHDLAGLLECKE--------IKFSLSE------------IKNIM------QQLFNALA--YIHGNN--IL
..|. ..||| ....|||..... . ...| . ||..| .|....|. |.| .. |.
YHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCHSHWGNII
HRDMKSCNILVTRKGEL--------------------KLADFGLARALNKGTNQR--------------------YTNRVVTLWYRPPELFLGE------
|||.| |||.. ..|| |..||||||.... ... ||..|||.|||.||. ||
HRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLGWKHYTNH
---RNYGPPIDMWGAGCIMAEMWTR--------RPIMQGDTE-----------QKQITLICQLCGSIS---------------PTEWAGVEKLEYYQK--
..|..|||||..|||.|||.|. .|. .|..| . |. .|....|... . || .. || .|.|
NYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKLPWYNKFP
-----------------------LELPQKENRKLKERLRHFV---------------------------------EDPYALDLIDKLLMLDPRKRIDADS
. .|.. ...|. . .|| |.||..|.| .|| ||| |.
KKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPDKRITAEQ
TLEHDFF
|.|..|
ALQHPYF
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| Kinase | AqueK100.AA | CDC2 | 20-234 | 34 | 2.9e-72 | 221.22 | In-house | 74-301 (301) | Show / Hide |
Range on Protein: 20-234 Range on HMM: 74-301/301 Sequence Identity: 34% (79 aa) SIYLVLDFCEHDLAGLLE-CKEI--KFSLSEIKNIMQQLFNALAYIHGNNILHRDMKSCNILVTRKGELKLADFGLARALNKGTNQRYT--NRVVTLWYR ..|.| .....|| ... . ..... .|..| |. ..... | . |.||| | |||. .||..|.|||||||| . .. || ||||||| KLYMVFEYLDMDLKKYMDMSIPKNKHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRT-YTTEHEVVTLWYR PPELFLGERNYGPPIDMWGAGCIMAEM---WTRRPIMQGDTEQKQITLICQLCGSISPTEWAGVEKLEYYQKL--ELPQKENRKLKER----LRHFVEDP .||. ||.. | |.||| |||.||| |..|. .|| | |. | . |. . .| ||..| .|. ..... .|. .. . . || APEILLGCKRYSTPVDMWSIGCIFAEMFMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPDYKNTFPRWKPQDLSKICPNNQKKKNQSCLDP YALDLIDKLLMLDPRKRIDADSTLEHDFF ..||....| .|| ||| |.. |.| .| EGIDLLMQMLQYDPQKRISAKEALQHPYF |
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| Kinase | AqueK100.AA | PITSLRE | 17-234 | 39 | 4.8e-72 | 245.67 | In-house | 74-295 (295) | Show / Hide |
Range on Protein: 17-234 Range on HMM: 74-295/295 Sequence Identity: 39% (90 aa) DKGSIYLVLDFCEHDLAGLLECKE---IKFSLSEIKNIMQQLFNALAYIHGNNILHRDMKSCNILVTRKGELKLADFGLARALNKGTN-QRYTNRVVTLW .. .||.|... ||||..|.| .|...||| |||| .. .. | | |.||| | |.| . || ||..|||||| | . || ||||| NMDKIYMVMEYVEHDLKSLMENMKRRNQPFKPGEIKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLYSHKGILKICDFGLAREY--GSPIKPYTPCVVTLW YRPPELFLGERNYGPPIDMWGAGCIMAEMWTRRPIMQGDTEQKQITLICQLCGSISPTE--WAGVEKLEYYQKLE-LPQKENRKLKERLR--HFVEDPYA || ||| || . | .|.||| |||.||. | .|..||. | || | .. | ||| | |. .| ... .|. |..| . | . YRAPELLLGCKKYSTPVDMWSVGCIFAEFITMKPLFQGKSEIDQINCIFKEMG--TPTEKIWPGWTELPHWKMMNNFPHYPYNNLRKRFPAENHISD-TG LDLIDKLLMLDPRKRIDADSTLEHDFF .|| ..| ..| .|| |. | |..| FDLLNQMLTYNPKNRITASDALKHPWF |
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| Kinase | AqueK100.AA | MAPK | 21-234 | 31 | 9.5e-63 | 214.78 | In-house | 91-328 (328) | Show / Hide |
Range on Protein: 21-234 Range on HMM: 91-328/328 Sequence Identity: 31% (75 aa) IYLVLDFCEHDLAGLLECKEIKFSLSEIKNIMQQLFNA--LAYIHGNNILHRDMKSCNILVTRKGELKLADFGLARALNKGTNQRY-------------T ||.| ...|.|| .... . | |. .| |. .. | ||| |..||| | .||||. ..||..|||||| . ..... | IYIVMELMETDLHQIIKSQQ-PLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMT NRVVTLWYRPPELFLG--ERNYGPPIDMWGAGCIMAEMWT-RRPIMQGDTEQKQITLICQLCGSISPTEWAGVE-KLEYYQKLE----LPQKENRKLKER |.| ||| ||. |. ..| .||| .|||.||| | |.|. .|. . |..|| ...|. |. . .. .... .. ||.. . ... EYVATRWYRAPEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKM LRHFV--EDPYALDLIDKLLMLDPRKRIDADSTLEHDFF . . .| |.||..|.| .|| |||... |.| .| FPNANFNANPQAIDLLEKMLVFDPDKRITVEEALQHPYF |
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| Kinase | AqueK100.AA | CDK5 | 23-234 | 36 | 1.3e-62 | 196.42 | In-house | 75-287 (287) | Show / Hide |
Range on Protein: 23-234 Range on HMM: 75-287/287 Sequence Identity: 36% (79 aa) LVLDFCEHDLAGLLECKEIKFSLSEIKNIMQQLFNALAYIHGNNILHRDMKSCNILVTRKGELKLADFGLARALNKGTNQRYTNRVVTLWYRPPELFLGE || || || .. . . .. || .| || ||. | ...||||.| | |. ..||||||||||||| . |. ||||||||| .| LVFEFCDQDLKKYMDSCNGEMDMHIIKSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVRC-YSHEVVTLWYRPPDVLMGS RNYGPPIDMWGAGCIMAEMW-TRRPIMQGDTEQKQITLICQLCGSISPTEWAGVEKLEYYQ--KLELPQKENRK-LKERLRHFVEDPYALDLIDKLLMLD . | .|||| .|||.||| . || | .. | .| .. |. . .| .. || |. ..| . .. ... .. | .|| |.|... KHYSTSIDMWSCGCIFAEMANAGRPLFPGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPK--LDEKGMDLLQKMLQCN PRKRIDADSTLEHDFF | .||.|. |.| .| PNQRISAKAALHHPYF |
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| Kinase | AqueK100.AA | Pkinase | 16-234 | 30 | 4.9e-60 | 210.55 | Pfam | 70-293 (293) | Show / Hide |
Range on Protein: 16-234
Range on HMM: 70-293/293
Sequence Identity: 30% (72 aa)
RDKGSIYLVLDFCEH-----DLAGLLE-CKEIKF--SLSEIKNIMQQLFNALAYIHGNNILHRDMKSCNILVTRKGEL----KLADFGLARALNKGTNQR
.||..||.|...||. ||. ... .. .| | |.|..| |.. .|.|.| ..|.|||.|. |||. ..|.. |..|||||. .. |.
EDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-
YTNRVVTLWYRPPELFLGERNYGPPIDMWGAGCIMAEMWTRRPIMQGD----TEQKQITLICQLCGSISPTEWAGVEKLEYYQKLELPQKENRKLKERLR
.| ...|.||..||. .| . |||..|||..|||..|| ..||. .|. . |. .||. | . . .| |. . . . ....
MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H---F-HWTF
HFVEDPYALDLIDKLLMLDPRKRIDADSTLEHDFF
.. ..|.|...| .|| ||. |. |.|..|
-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
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| Kinase | AqueK100.AA | CDK10 | 20-234 | 39 | 2.9e-59 | 203.19 | In-house | 74-285 (285) | Show / Hide |
Range on Protein: 20-234 Range on HMM: 74-285/285 Sequence Identity: 39% (85 aa) SIYLVLDFCEHDLAGLLECKEIKFSLSEIKNIMQQLFNALAYIHGNNILHRDMKSCNILVTRKGELKLADFGLARALNKGTNQRYTNRVVTLWYRPPELF ||.||...|| ||| ||. |. ...| || |. .| |.| | ..|||.| |.|.| || .|.|||||||. . | ..|||||| ||| SIFLVMQYCEQDLASLLDNMPQPFTETQVKCIMLQMLRGLKYLHDNFMIHRDLKVSNLLMTDKGCIKVADFGLARMYGVPV-KPMTPKMVTLWYRAPELL LGERNYGPPIDMWGAGCIMAEMWTRRPIMQGDTEQKQITLICQLCGSISPTEWAGVEKLEYYQKLELPQKENRKLKERLRHFVEDPYALDLIDKLLMLDP || |. |||| .|||..|. .|.| | | .|| .| .| |. | . | | .| |. | .. ||.. . . |.. |.| .| LGCRTQTTAIDMWAVGCILGELLVHKPLMPGNSEIHQIDMIIDLLGTPSENIWPGFSDLPMVQNFTLKKQPYNNLKHKFHWLSQS--GRRLLNFLFMYNP RKRIDADSTLEHDFF .|| |. .|| .| KKRATAEECLESSYF |
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| Kinase | AqueK100.AA | CDK-DD1 | 23-191 | 40 | 5.7e-54 | 164.74 | In-house | 75-248 (379) | Show / Hide |
Range on Protein: 23-191 Range on HMM: 75-248/379 Sequence Identity: 40% (72 aa) LVLDFCEHDLAGLLECKEIKFSLSEIKNIMQQLFNALAYIHGNNILHRDMKSCNILVTRKGELKLADFGLARALNKGTNQRYTNRVVTLWYRPPELFLGE .|. . |||| ... . ||. ||. . || . .| . | ||| | | |.. .| ||..|||.. | .||.|||||||| .| MVFEYFEHDLWKFMSNHQCYMSLPCIKCFFHQLLEGINECHNQGIMHRDIKPANLLINNRGDLKITDFGFTTYYTKRSEKHFSHQVVSLWYRPPELLMGS RNYGPPIDMWGAGCIMAEMWTRRPIMQGDTEQKQITLICQLCGSISPTE--WAGVEKLE-YYQKLELP----QKEN ..||| |||| |||. || | . .. | || | ||| ||| ||| | || .| | | . .. | || CQYGPEIDMWSVGCILMEMITNFYMFAGSNEQQQLELICKLCG--CPTEKNWPGVSQLQGYNQYFHKQQQQQQNEN |
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| S_TKc | AqueK100.AA | S_TKc | 4-234 | 22 | 5e-41 | 143.53 | SMART | 14-231 (231) | Show / Hide |
Range on Protein: 4-234 Range on HMM: 14-231/231 Sequence Identity: 22% (62 aa) QVLLFLSAT--------------------------------PYNRDKGSIYLVLDFCEH---DLAGLLECKEIK-----FSLSEIKNIMQQLFNALAYIH .| . . .| ...|.|...|.. || ... . . |. ... .|.|...||.|.| KVYKCRHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCH GNNILHRDMKSCNILVTRKGELKLADFGLARALNKGTNQRYTNRVVTLWYRPPELFLGERNYGP-PIDMWGAGCIMAEMWTRRPIMQGDTEQKQITLICQ ..|.||| | |||... ..|..|||||| | | ..|.||..||.. ||. ..|.| |||..|| ...| . |. .. . SHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEMLCGYPPFP------QMQMMFK LCGSISPTEWAGVEKLEYYQKLELPQKENRKLKERLRHFVEDPYALDLIDKLLMLDPRKRIDADSTLE-------HDFF ..| .| |.|.|.|.| ||.||. | |. | .| KIG--------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | AqueK100.AA | CDK-DD1 | 192-234 | 41 | 7.9e-11 | 29.04 | In-house | 337-379 (379) | Show / Hide |
Range on Protein: 192-234 Range on HMM: 337-379/379 Sequence Identity: 41% (18 aa) RKLKERLRHFVEDPYALDLIDKLLMLDPRKRIDADSTLEHDFF .|| .. | | | |||| ..| |.| ||| . |.| .| KKLIDKFPHLVLLPSFLDLIERMLTLCPKKRINTKEALQHPWF |
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| Kinase | AqueK100.AA | Pkinase_Tyr | 16-100 | 27 | 1.8e-07 | 25.94 | Pfam | 75-166 (270) | Show / Hide |
Range on Protein: 16-100 Range on HMM: 75-166/270 Sequence Identity: 27% (25 aa) RDKGS--IYLVLDFCEH-DLAGLLECK---EIKFSLSEIKNIMQQLFNALAYIHGNNILHRDMKSCNILVTRKGELKLADFGLARAL-NKGT ..... ||.|. ...| || | . . ....... .. .| ....| . .|. ||| |.|||... | .||||||.. |... DQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDY |
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| TyrKc | AqueK100.AA | TyrKc | 1-167 | 13 | 0.000244 | -152.47 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 1-167
Range on HMM: 1-280/280
Sequence Identity: 13% (37 aa)
MHLQVLL-----------------------------------FLSAT-PYN----------RDK-------GSIYLVLDFCEH-DLAGLLECKEIKFSLS
.| | .. . . ... . ...|. ...| || | .. |....
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMK
EIKNIMQQLFNALAYIHGNNILHRDMKSCNILVTRKGELKLADFGLARALNKG-----TNQRYT-----NRV--VTLWYRPPELF---------------
. ... | . .|.| .|. ||| |.||.... | .||||.|.. . . |. .. . . .|| .
DLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFG
--------LGERNYGPPIDMWGAGCIMAEMWT------RRPIMQG---------DTEQKQITLIC------------QLCGSI
.|. | .| . . .|. |.|... .| || . | ... .
VCMWEIFTYGQQPYPGMIQQ---MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
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