Gene n518 (Tetrahymena)
n518
Species: Tetrahymena
Alias: n518, 3700.m01693, 518
External Links:
Annotation:
Group:
Other
Family:
Ciliate-B1
Sequence
Protein domains of n518.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | n518.AA | Ciliate-B1 | 114-389 | 43 | 3e-145 | 488.82 | In-house | 1-290 (290) | Show / Hide |
Range on Protein: 114-389 Range on HMM: 1-290/290 Sequence Identity: 43% (126 aa) LQLENVIGKGAVSEVFLGN-QQNSYLQREYEVCLKIKSVQDNDEKQGKLNHNVLRILDCLDFKANENKISCQSSRVNPANTYNNLIDYIQEKYIITEYCN |..||||.||.|.||.|. .||...|.|..|....|..||||..|.|.....|.|..||..|.|.||||||||...........|...|..|||.|||. YQQNNVIGQGAISQVFYGQFCQNQQCQQEVAVKKITKQTQDNDKQQNKYYQQELEIIQCLIKKMNNNKISCQSSPCDHICNIYDVIQCQQQYYIIMEYCE KSSLYDYLTDKGFSLQLTEVLDTSMQIAQGLKFLHDQKIMHRDLKPENIFVHEVN--------QDKYLFKIGDFGIGKQFQEEGIEQSFVGTINYMSPEV ...||.|............|||...|||.|...||..||.|||||||||..|..| |..|.|||.||||.|..||. ..||.|||||||.||. QGDLYNYIYNCHQNFTHDIVLDFCIQIAKGIQYLHKHKICHRDLKPENILIHKKNVPIYYNKQQNHYIFKITDFGISKMQQEY-MMQSCVGTINYMAPEI IN-RQQYSNQIDYWSLGCIIYEIYKGYQMFR--GYTEKEVEEKIKNFRS---QQHFVFSLNISLEN-IIHKCLVSSNQGGYQNIDQIINDIQ .| .|||....|.||.|||.|||....|.|. |.|..||...|.|| | || .. . .. |. .|| . .. . |||||... LNFNQQYDKKVDIWSFGCIMYEIITNEQLFCSLGNTQQEVANQIRNFQCCDYQCHFQNNIYQEIQQLIQKYCL-QPDPENRITIDQIIDRLM |
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| Kinase | n518.AA | Pkinase | 205-335 | 36 | 2.1e-43 | 154.58 | Pfam | 76-214 (293) | Show / Hide |
Range on Protein: 205-335 Range on HMM: 76-214/293 Sequence Identity: 36% (52 aa) YIITEYCNKS----SLYDYLT-DKGFSL--QLTEVLDTSMQIAQGLKFLHDQKIMHRDLKPENIFVHEVNQDKYLFKIGDFGIGKQ--FQEEGIEQSFVG |...|||.. .|.||.. ... .. . |. . ||..||...|...|.|||||||||.... .. . .||.|||. || . ..|.| YMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCG TINYMSPEVIN-RQQYSNQIDYWSLGCIIYEIYKGYQMFRG |..||.||||. .| |. .| ||.|||.|| . |. |.| TPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPG |
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| Kinase | n518.AA | S_TKc | 114-385 | 23 | 2.2e-38 | 134.76 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 114-385 Range on HMM: 1-231/231 Sequence Identity: 23% (68 aa) LQLENVIGKGAVSEVFLGNQQNSYLQREYEVCLKIKSVQDNDEKQGKLNHNVLRILDCLDFKANENKISCQSSRVNPANTYNNLIDYIQEKYIITEYCNK .. ..||||| ..|... . .| .|| . ...| ...| .| . . . .. .. |...|||. YEILRKIGKGAFGKVYKCRHKK----TGRIVAIKIIK------------EHIRREIQILKK-HHPNIVKLYDVFQD------------DHLYMVMEYCDG --SSLYDYLTDKGFS-----LQLTEVLDTSMQIAQGLKFLHDQKIMHRDLKPENIFVHEVNQDKYLFKIGDFGIGKQFQEEGIEQSFVGTINYMSPEVIN .|.||. ..| . .. ||...|...|...|.|||||||||.. | ||.|||. .|. .|.|| .||.|||. DLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL------TTFCGTPWYMAPEVL- RQQYSN-QIDYWSLGCIIYEIYKGYQMFRGYTEKEVEEKIKNFRSQQHFVFSLNISLENIIHKCLV------SSNQGGYQ-----NIDQII .|. .| ||.|||.|| . || |. ..... .||. .. ..| |||. . | .... . --GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | n518.AA | Ciliate-E2 | 114-371 | 17 | 4.9e-37 | 124.68 | In-house | 1-346 (365) | Show / Hide |
Range on Protein: 114-371
Range on HMM: 1-346/365
Sequence Identity: 17% (67 aa)
LQLENVIGKGAVSEVFLG----NQQNSYLQREYEVC--------------LKIKSVQDNDEKQGKLNHNVLRILDCLDFKANENKISCQSSRVNPANTYN
. ..||.|. . |... .|... ..... .|... |. .| | ...| ..| . |
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINC-F--------------------YK
-----------------NLIDYIQ--EK---YIITEYCNKSSLYDYLTDKGFS----------LQLTEVLDTSMQIAQ---------------GLKFLHD
..... | . |...|||. .|.||. .. . . . |... . ||.| .|..||
KINEKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHS
QK-IMHRDLKPENIFVHEVNQDKYLFKIGDFGIGKQFQEEGIEQS--------------------------------FVGTINYMSPEVINRQQ------
.. |.|||.|||||.. || |||. |..... .... ..|| .||.||..|...
KNNIIHRDIKPENILF---------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQK
---YSNQIDYWSLGCIIYEIYKGYQMFRGYTEKEVEEKIKNFRSQQHFVF--------------SLNISLE--NIIHK----CLV
|. ..|.||||.|.|| |. | ...||. . . . ...|.| ..| | .|.
QKGYDYKCDIWSLGVILYEMLFGKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQ
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| Kinase | n518.AA | ULK | 197-326 | 30 | 2.5e-36 | 124.36 | In-house | 83-249 (329) | Show / Hide |
Range on Protein: 197-326 Range on HMM: 83-249/329 Sequence Identity: 30% (51 aa) LIDYIQEK-----YIITEYCNKSSLYDYLTDKG---------FSLQLTEVLDTSMQIAQGLKFLHDQKIMHRDLKPENIFVHE---------VNQDKYLF |.|. ... |||.|||| | .|. .. | |.. .||..|.|.||...|.|||.||.|| .|. |.. .. . LYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHP-NGVL KIGDFGIGKQFQEE----GIEQSFV------GTINYMSPEVIN----RQQYSNQ-IDYWSLGCIIYEI ||.||| .|..... .....| || ||.|.... ...|.. | ||||||.||. KIADFGFAKHVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEM |
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| Kinase | n518.AA | Ciliate-E2-Unclassified | 116-371 | 20 | 4.2e-35 | 119.22 | In-house | 3-334 (352) | Show / Hide |
Range on Protein: 116-371
Range on HMM: 3-334/352
Sequence Identity: 20% (73 aa)
LENVIGKGAVSEVFLGNQQNSYLQ---------REYEVCLK------------IKSVQ-DNDEKQGKLNHNVLRILDCLDFKANENKISCQSSRVNPANT
. .||.|. ..|.. . . ... ..| .... ... . ....| . ||| |. . .|
IIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRK-------------------Y-NKIMQQILLNHPHPF
YNNLIDYIQEK---YIITEYCNKSSLYDYLTDKGF----------------SLQLTEVL-----DTSMQIAQGLKFLHDQK-IMHRDLKPENIFVHEVNQ
..... | | ||..|||. .| .|...... .. ... . || |||..|| .. | |||.|||||.... ..
IVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGK
DKYLFKIGDFGIGKQFQE----------------EGIEQSFVGTINYM----SPEVINRQQYSNQ----IDYWSLGCIIYEIYKGYQMFRGYTEKE----
.| || |||| |. |. . . ..|.||.||| .|||. .|.|... .|.||||.|.||. || | ......
-NYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQL
------------VEEKIKNFRSQ----------QHFVFSLNISLENIIHKCLV
....||. | .| .. ......|.|.
ITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLK
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| Kinase | n518.AA | NEK | 205-326 | 38 | 6e-35 | 120.69 | In-house | 82-217 (286) | Show / Hide |
Range on Protein: 205-326 Range on HMM: 82-217/286 Sequence Identity: 38% (52 aa) YIITEYCN-KSSLYDY---LTDK---GFSLQLTEVLDTSMQIAQGLKFLHDQ-----KIMHRDLKPENIFVHEVNQDKYLFKIGDFGIGKQFQEEGIEQS .|. |||. . ||. . . | .. ...| |.. .||..||. ||.|||.|| ||| | | . ||||||| |... . .. CIVMEYCEGGGDLYQKIKSIKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAY --FVGTINYMSPEVINRQQYSNQIDYWSLGCIIYEI .||| ||||||.. . |.| | |||||..||. TTQVGTPYYMSPEVCQNKPYNNKSDIWSLGCVLYEM |
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| Kinase | n518.AA | CAMK | 196-324 | 20 | 3.8e-34 | 106.89 | In-house | 102-325 (425) | Show / Hide |
Range on Protein: 196-324
Range on HMM: 102-325/425
Sequence Identity: 20% (47 aa)
NLIDYIQ----------------------EKYIIT---EYCNKS----SLYDYLTDKGF--------------SLQLTEVLDTSMQIAQGLKFLHDQKIM
.|..... . |... ||| |.||....| .. |. ||.......|...|.
KLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIV
HRDLKPENIFVHEVNQDK-------------YLFKIGDFGIGKQFQEEGIEQ------------------------SFVGTINYMS-PEVINRQQ-----
||||||||| . . | |. . || ||| ..|.. . |.|| ||. |||.|...
HRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQ
---------YSNQIDYWSLGCIIY
|. ..| ||.|.| |
NATDEEKPYYGPKCDMWSCGVILY
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| Kinase | n518.AA | ULK | 197-368 | 26 | 4.4e-34 | 118.35 | In-house | 80-295 (324) | Show / Hide |
Range on Protein: 197-368 Range on HMM: 80-295/324 Sequence Identity: 26% (59 aa) LIDYIQEK-----YIITEYCNKSSLYDYLTDKG--------FSLQLTEVLDTSMQIAQGLKFLHDQKIMHRDLKPENIFVHE---------VNQDKYLFK |.|. ... |||.|||| | .|. .. | |.. .||..|.|.||...|.|||.||.|| .|. |.. .. .| LYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHP-NGVLK IGDFGIGKQFQEEG----IEQSFV------GTINYMSPEVIN----RQQYSNQ-IDYWSLGCIIYEIYKGY-----QMFRGYTEKEVEEKIKN------F |.||| .|...... . |..| || ||.|.... ...|.. | ||||||.||. |. . |. . .. ... |.| . IADFGFAKHVDNNNMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLY-IQKLINNGKEQQIY RSQQHFVFSLNISLENIIHK .| . | ... ...| . IKNQPIQFPKPP-KDPKISP |
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| Kinase | n518.AA | CAMK-Unique | 205-346 | 25 | 8.8e-34 | 108.75 | In-house | 111-314 (363) | Show / Hide |
Range on Protein: 205-346 Range on HMM: 111-314/363 Sequence Identity: 25% (51 aa) YIITEYCNKSSLYDYLTD-----------------KGFSLQLTE----VLDTSMQIAQGLKFLHDQKIMHRDLKPENIFVHEVNQD------------KY ||..|||.. |.|.. . | ...| .. . .... ....|.|.| |||||.||| | . .| . YIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHHRDFPYDWSNW LFKIGDFGIGKQFQEEGIEQ---SFVGTINYMSP--------------EVINRQQYSNQI----DYWSLGCIIYEIYKGYQMFRGYTEK--------EVE |. |||. ..... . ...||. ||.| ||||.| |. | | |||| | |. |. | . .|. | . HIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDCECEDRDYENHDKEIF EKIK |.|. ECIC |
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| Kinase | n518.AA | TKL | 205-327 | 24 | 2.4e-33 | 117.09 | In-house | 114-283 (364) | Show / Hide |
Range on Protein: 205-327 Range on HMM: 114-283/364 Sequence Identity: 24% (43 aa) YIITEYCNKSSLYDYLTDKGFSLQLTEVLDTSMQIAQGLKFLHDQK--------IMHRDLKPENIFVHEVNQ----------DKYLFKIGDFGIGKQFQE .|..||| . ||..||. . .. ...||.|. .|| .. | |||||..||.|.| .. . . ||.|||. . ... CIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQ EG--------------------IEQSFVGTINYMSPEVINRQ----------------QYSNQIDYWSLGCIIYEIY .| . .||...|.|||.. | .|| ..| .| | ...||. SGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEIL |
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| Kinase | n518.AA | STE | 205-325 | 28 | 1.5e-31 | 108.68 | In-house | 113-260 (359) | Show / Hide |
Range on Protein: 205-325 Range on HMM: 113-260/359 Sequence Identity: 28% (45 aa) YIITEYCNKSSLYDYLT---DKGFSLQ----------LTEVLDTSMQIAQG-LKFLHDQKIMHRDLKPENIFVHEVNQDKYLFKIGDFGIGKQFQEEGIE .|. ||.. || | . .|..|. ... || .| |..||...|.|||.|| ||.. |. |||. .|..... . WICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL---------VKLCDFGVCGQLTDSMAN Q-----------------SFVGTINYMSPEVINR------QQYSNQIDYWSLGCIIYE . .|||| .|.||||.. ..|. . | ||||| | | IQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIE |
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| Kinase | n518.AA | Pkinase_Tyr | 205-327 | 29 | 1.3e-13 | 46.75 | Pfam | 83-208 (270) | Show / Hide |
Range on Protein: 205-327 Range on HMM: 83-208/270 Sequence Identity: 29% (39 aa) YIITEYCNKSSLYDYLTDK---GFSLQLTEVLDTSMQIAQGLKFLHDQKIMHRDLKPENIFVHEVNQDKYLFKIGDFGIGKQFQEEGIEQSFVGT----- ||..||. . .|.||| .. . .| . . |. ..|||.|. .|..... |||| |. |.| . ||.||| . .... . ... YIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE----NNVVKICDFGLARDIYNDDYY-YRKRGGGKLP INYMSPEVINRQQYSNQIDYWSLGCIIYEIY | |.||.|| .. . | || | ..||. IKWMAPECINYGKFTTKSDVWSFGVLMWEIF |
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| Kinase | n518.AA | TyrKc | 114-388 | 21 | 6.5e-11 | -46.19 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 114-388
Range on HMM: 1-280/280
Sequence Identity: 21% (67 aa)
LQLENVIGKGAVSEVFLGNQQNSYLQREYEVCLKIKSVQDNDEKQ---------GKL--NH-NVLRIL-DCLDFKANENKISCQSSRVNPANTYNNLIDY
..|. ..| || ||..| . . .|..... .. || .| |..|.. |.. . | |
ITLGKKLGEGAFGEVYKGTWK--------IQVA-VKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN--------------------FMY
IQEKYIITEYCNKSSLYDYLTDKGFSLQLTEVLDTSMQIAQGLKFLHDQKIMHRDLKPENIFVHEVNQDKYLFKIGDFGIGKQFQEE------GIEQSF-
|. .|..||. . .| ||| ... |.. . |. . |||.| .||.... |||| |. |.| . ||.||| . .. . .
IEPLMIVMEYMPHGDLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQGESKDYYRKK
---VGT----INYMSPEVINRQQYSNQIDYWSLGCIIYEIY-KGYQMFRG-----YTEKEVEEKIKNFRSQQHFVF-------SLNISLENIIHKCLVS-
| | |.||.|| .. . | || | ..||. | | | . .|| |..|. . . .|. .|
EHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHED
SNQGGYQNIDQIINDI
.. . .|. ..
PEDR--PTFSEIHECF
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| Kinase | n518.AA | CAMK | 119-131 | 30 | 0.042742 | 1.74 | In-house | 1-13 (425) | Show / Hide |
Range on Protein: 119-131 Range on HMM: 1-13/425 Sequence Identity: 30% (4 aa) VIGKGAVSEVFLG ..|.|. ..|.|. TLGRGSFGKVKLC |
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| Kinase | n518.AA | TKL | 120-157 | 23 | 0.172881 | 1.14 | In-house | 1-42 (364) | Show / Hide |
Range on Protein: 120-157 Range on HMM: 1-42/364 Sequence Identity: 23% (10 aa) IGKGAVSEVFLGNQQNSYLQRE-----YEVCLKIKSVQDNDEK ||.|. .||. |. .. .. ..| |. .....||. IGSGGFGEVYKGKWRGWGG-KCPSDTGKDVAVKKFKSHNDDEF |
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| Kinase | n518.AA | ULK | 114-135 | 28 | 0.249347 | 0.55 | In-house | 1-25 (324) | Show / Hide |
Range on Protein: 114-135 Range on HMM: 1-25/324 Sequence Identity: 28% (7 aa) LQLENVIGKGAVS-EVFLG--NQQN .| ...|||. |. | ...| YCLNHCLGKGSFGVKVYKGRNKKTN |
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| Kinase | n518.AA | ULK | 114-135 | 25 | 0.322214 | 0.11 | In-house | 1-24 (329) | Show / Hide |
Range on Protein: 114-135 Range on HMM: 1-24/329 Sequence Identity: 25% (6 aa) LQLENVIGKGAVSEVFLG--NQQN .| ...|||. |. | .... YCLNHCLGKGSFGKVYKGRNKKTK |
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| Kinase | n518.AA | Pkinase | 114-158 | 15 | 4.385331 | 1.38 | Pfam | 1-41 (293) | Show / Hide |
Range on Protein: 114-158 Range on HMM: 1-41/293 Sequence Identity: 15% (7 aa) LQLENVIGKGAVSEVFLGNQQNSYLQREYEVCLKIKSVQDNDEKQ .... .||.|. ..|... ... .|..|| ......... YHIGRKIGSGSFGCVYKCHHKGTGK----IVAVKIIKKRHEKSWK |
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