Gene ILK (Sea Urchin)

ILK

Species: Sea Urchin
Alias: SPU_025428, ILK, Spk310
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: ILK

Sequence

Name Sequence Type Origin Length Description Download
ILK.AA Protein None 448 None Fasta, JSON
ILK.kin_dom Protein Kinase Domain None 245 None Fasta, JSON

Protein domain

Protein domains of ILK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Ank ILK.AA Ank 99-131 33 1.6e-09 38.59 Pfam 1-33 (33) Show / Hide 
Range on Protein: 99-131
Range on HMM: 1-33/33
Sequence Identity: 33% (11 aa)

HGNTPLHYACFWNYEQICQDLINNGALVALSNK
.|.||||.||..........|...|| | . ..
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank ILK.AA Ank 33-65 42 3.8e-09 37.25 Pfam 1-33 (33) Show / Hide 
Range on Protein: 33-65
Range on HMM: 1-33/33
Sequence Identity: 42% (14 aa)

HGFSAMHWACKEGRTNIVDMLISRGAKINATNM
.||.. |.||. |.|..| ||...|| .||.. 
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank ILK.AA Ank 66-98 45 4.9e-08 33.25 Pfam 1-33 (33) Show / Hide 
Range on Protein: 66-98
Range on HMM: 1-33/33
Sequence Identity: 45% (15 aa)

GDDTALHLAAAHGHRDIVLKLIQHRADINAMNE
  .|.||||. .|| ..|  |.|| ||.|| . 
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Kinase ILK.AA ILK 191-441 72 6.5e-228 763.44 In-house 1-253 (253) Show / Hide 
Range on Protein: 191-441
Range on HMM: 1-253/253
Sequence Identity: 72% (183 aa)

VKLQSKINSSPTGDMWKGIWQGTAVMAKVLKVTNVTSRISREFGEEFPRLRIFSHPNIHPVLGCVNQP--PNLVVLSETLQHGSLFHVLHEASGIVVDHG
..|..|||.|..|.||.|.|||....||.|||...|.||||.|.||||||||||||||.|||||.|||  ||||..|....||||.||||||.|.|||||
LNLHTKINESHSGEMWRGRWQGNDIVAKILKVRQWTTRISRDFNEEFPRLRIFSHPNICPVLGCCNQPPAPNLVIISQWMPHGSLYHVLHEATGVVVDHG

QMVSFALDIARGMSFLHAMDPLIPRYYLNSKNIMIDEELTAKINMGDTRFSFQNRAKFFNPAWMAPEALQKSPEEMNARSADMWSFAILIWELVTREVPF
|||||||||||||||||.|||.||||||||...||||..||.||||||.||||.|.....||||||||||..||.||.||.|||||||||||||||||||
QMVSFALDIARGMSFLHSMDPMIPRYYLNSHHVMIDEDMTARINMGDTKFSFQCRGRMYQPAWMAPEALQRKPEDMNWRSCDMWSFAILIWELVTREVPF

AGMSSMEVGMKIVGEGLRIDVPPGSSPHMSKLIKICMNEDSTKRPRFDMIMPI
|..|.||.||||..||||...|||.||||.||.|||||||..|||.||||.||
ADWSPMECGMKIALEGLRVHIPPGISPHMCKLMKICMNEDPGKRPKFDMIIPI
Kinase ILK.AA MLK 191-442 32 5.9e-128 431.4 In-house 1-291 (291) Show / Hide 
Range on Protein: 191-442
Range on HMM: 1-291/291
Sequence Identity: 32% (96 aa)

VKLQSKINSSPTGDMWKGIWQGTAVMAKVLKVTNVTSRI---------SREFGEEFPRLRIFSHPN----IHPVLGCVNQPPN-LVVLSETLQHGSLFHV
 ... .|.|.. |..||| |... ..||...| .|..||         ...| .|...|||.||||    |....|. .|||. .....| ...|||..|
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

LHEASG------------IVVDHGQMVSFALDIARGMSFLHAMDP-LIPRYYLNSKNIMIDE------ELTAKINMGDTRFSFQNR-----AKFFNPAWM
||.|..            .|.||......||..||||..||.|.| .|....|.|.||.|||      ..|.||....| ......      . ...|||
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMMSNAGTYAWM

APEALQKSPEEMNARSADMWSFAILIWELVTREVPFA-GMSSMEVGMKIVGEGLRIDVPPGSSPHMSKLIKICMNEDSTKRPRFDMIMPIL
|||..|....|.. ...|.||.....||..|||||.. ....|....... .|||  .|.. ..|..||.|.|.|.|. ||| |..|...|
APEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase ILK.AA TKL 197-442 24 1.2e-65 224.41 In-house 1-364 (364) Show / Hide 
Range on Protein: 197-442
Range on HMM: 1-364/364
Sequence Identity: 24% (92 aa)

INSSPTGDMWKGIWQG----------TAVMAKVLKVTN-------------------------VTSRISREFGEEFPRLRIFSHPNIHPVLGCVNQPPN-
| |   |  .||.|.|          . |  |..|..|                          .|..  .. ||   .. ..|||| . .|....||. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------LVVLSETLQHGSLFHVLHEASGIVVDHGQMVSFALDIARGMSFLHAMD------PLIPRYYLNSKNIMIDEELT--------------
            |    |  ..|||.|.||        . |....||||||||..||.|.      | |    |.||||..|| .|              
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWC

AKIN-MGDTRFSFQNRA-----------------------KFFNPAWMAPEALQKSPEEMNA-------------RSADMWSFAILIWELVTREVPFA--
.||  .|  || .|.                         .  .|.|||||.|.....  ..              ..|..||.|..||..||..|..  
CKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDY

GMSSMEVG-------MKIVGEGLRIDVP------------PGSSPHMSKLIKICMNEDSTKRPRFDMIMPIL
....|...       |... .|||  .|            |   |.|.||.. |...| .||| |. |. .|
PYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase ILK.AA TKL-Unique 193-442 27 1.4e-32 112.31 In-house 1-290 (290) Show / Hide 
Range on Protein: 193-442
Range on HMM: 1-290/290
Sequence Identity: 27% (79 aa)

LQSKINSSPTGDMWKGIWQGTAVMAKVLKV-TNVTSRISREFGEEFPRLRIFS-HPNI-HPVLGCVN---QPPNLVVLSETLQHGSLFHVLHE-------
  .|| ..  |   ||.| |. |  |....   . .....|| .|   .  .  |||| | . .|.    .|||.   .| ...|||  |||        
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN

-ASGIVVDHGQMVSFALDIARGMSFLHAMDPLIPRYYLNSKNIMIDEE-----LTAKI-NMGDTRFSFQNRAKFFN-------------PAWMAPEALQK
 .. .  .  |.|..|.|||.|| .||  .| |    | |.|. .|..     . .||   |  .|. .. ....|             . ||||| |  
NNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRM

SPEEMNARSADMWSFAILIWELVTREV------PFAGMSSMEVGMKIVG--EGLRIDVPPGSSPHMSKLIKICMNEDSTKRPRFDMIMPIL
.  ..  ...| .||.|  ||..||..      |. ||.. ..  ..    |..|  .|.   .  ..||. | . |...|| || |   |
NF-CQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase ILK.AA TKL-ciliate2 191-443 27 1.2e-27 88.88 In-house 1-273 (273) Show / Hide 
Range on Protein: 191-443
Range on HMM: 1-273/273
Sequence Identity: 27% (75 aa)

VKLQSKINSSPTGDMWKGIWQGTAVMAKVLKVTNVTSRISREFGEEFPRLRIFSHPNIHPVLGCVNQPPNLVVLSETLQHGSLFHVLHEASGIVVDHGQM
...| ||     | ..|  |  . |  |  |.     .  |.| .|   .    ||||   ||   . ||  .. |  |.|||. .| . . . .     
LEIQNKITEGGYGIIYKAKWREIVVAVKKFKMDHDNQQQIRDFVNECHAMEALRHPNIVMFLGACTKIPNFCIIMEYCQRGSLWSLLQNQD-VRLTWEDR

VSFALDIARGMSFLHAMDPLIPRYYLN--------------------SKNIMIDEELTAKI-NMGDTRFSFQNR---AKFFNPAWMAPEALQKSPEEMNA
   |||||||. .||. .| |    |                     | |...|. .  |.   | ||   |     .|     ||||| ..     .  
RRIALDIARGVHYLHSSNPPIIHRDLKRQIKHKEKNLINIITLIKINSLNVLVDDNFRCKLTDFGWTRVKPQDNYMTNKIGTYQWMAPEVIK---AFYYT

RSADMWSFAILIWELVTREVPFAGMSSMEVGMKIVGEGLRIDVPPGSSPHMSKLIKICMNEDSTKRPRFDMIMPILE
  ||..|..|..||.  || |. ...   |  |.. . ||  .|    | .. |.. | ...   || |. |.  ||
EKADVFSYSIILWEIASREPPYRNKKGDVVAEKVMCNNLRPTIPKNCPPQFADLMQRCWDNNQNLRPSFNEIIKELE
Kinase ILK.AA Dicty4-Unclassified 207-442 27 1.5e-27 91.42 In-house 17-263 (263) Show / Hide 
Range on Protein: 207-442
Range on HMM: 17-263/263
Sequence Identity: 27% (70 aa)

KGIWQGTAVMAKVLKVTNVTSR--ISREFGEEFPRLRIFSHPNIHPVLGCVNQP----PNLVVLSETLQHGSLFHVLH-----EASGIVVDHGQMVSFAL
||.| |  |  | .       |  .  .|  |   |   .|||   . |    |      ...  | .  | || | |         |  |    . .|.
KGNWKGKDVAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPSEQQQPIKLDDTLIIKYAF

DIARGMSFLHAMDPLIPRYYLNSKNIMIDEELTAKI-NMG---DTRFSFQNRAKFFNPAWMAPEALQKSPEEMNARSADMWSFAILIWELVTREVPFAGM
|||.|| .||  . .| |  . | ||..|    .||  .|    . | |   .    |.| .|| |     |     .| .|.|.. .||.| . |. . 
DIAQGMQHLHTRN-FIHR-DIKSSNILMDKHFNIKIADFGISRVIDFNFNMTTIAGTPKWESPECLM---HESYNQKSDVYSYAMMLYELATGDEPYQEI

S-SMEVGMKIVGEGLRIDVPPGSSPHMSKLIKICMNEDSTKRPRFDMIMPIL
   |...  .   .||  .|    . ..|||| |. .|  ||| .. |   |
QSIMNAARSVCDKKLRPKIPDNCDNFWKKLIKWCWHNDPNKRPTMNQIIQYL
Kinase ILK.AA DRK 349-444 35 4.9e-24 78.31 In-house 166-258 (258) Show / Hide 
Range on Protein: 349-444
Range on HMM: 166-258/258
Sequence Identity: 35% (34 aa)

PAWMAPEALQKSPEEMNARSADMWSFAILIWELVTREVPFAGMSSMEVGMKIVGEGLRIDVPPGSSPHMSKLIKICMNEDSTKRPRFDMIMPILER
| | ||| |    ..     || .||||  ||.|||. |..||  . | . .  .|.|  .|.  .|   .|.. | ||| . || .. ....|| 
PCWTAPEVLR---NQRYTEKADVYSFAIVLWECVTRQDPYFGMPTFQVVFSVGRHGMRPPMPQWCPPKYIQLMNDCWNEDPQHRPSMQECLERLEA
Kinase ILK.AA MLK 350-442 35 4e-21 66.36 In-house 191-280 (280) Show / Hide 
Range on Protein: 350-442
Range on HMM: 191-280/280
Sequence Identity: 35% (33 aa)

AWMAPEALQKSPEEMNARSADMWSFAILIWELVTREVPFAGMSSMEVGMKIVGEGLRIDVPPGSSPHMSKLIKICMNEDSTKRPRFDMIMPIL
||||||....|   .  .. | ||. .| |||.|.|||. |.  . |   .   .|   .|       .||.. | | |  ||| |  |.  |
AWMAPEVIKES---TWSKGSDVWSYGVLLWELLTGEVPYRGIDPLAVAYGVAMNKLTLPIPSTCPEPWAKLMQDCWNQDPHKRPKFSEILQQL
Kinase ILK.AA Dicty4 349-444 33 1.5e-19 61.99 In-house 181-277 (277) Show / Hide 
Range on Protein: 349-444
Range on HMM: 181-277/277
Sequence Identity: 33% (33 aa)

PAWMAPEALQKSPEEMNARSADMWSFAILIWELVTREVPFA--GMSSMEVGMKIVGEGLRIDVPPGSSPHMSKLIKICMNEDSTKRPRFDMIMPI--LER
|.||||| ...  .. |  .||  ||.|. ||..||. |..  .|. |...  .. ..||  .|.  .|  ..||. | ..| ..|| |  | ..  || 
PCWMAPEVMMH--QPYNE-KADVYSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase ILK.AA DRK 191-331 32 1.1e-17 56.54 In-house 1-141 (258) Show / Hide 
Range on Protein: 191-331
Range on HMM: 1-141/258
Sequence Identity: 32% (46 aa)

VKLQSKINSSPTGDMWKGIWQGTAVMAKVLKVTNVT-SRISREFGEEFPRLRIFSHPNIHPVLGCVNQPPNLVVLSETLQHGSLFHVLHEASGIVVDHGQ
.| .  |     |. . | | || |  | |.  |.    .  ||  |   .    ||||   .|  | ||   .  | .  |||  .||. | |  | . 
IKIGNRIGRGNYGEVFRGTWRGTQVAVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDES-IEMDWPL

MVSFALDIARGMSFLHAMDPLIPRYYLNSKNIMIDEELTAKI
| . ..|.|.|| .||  .| |    | | |  .||    |.
MKQMMFDCAKGMIYLHCCNPIIIHRDLKSHNLLVDEHWQVKV
Kinase ILK.AA Pkinase_Tyr 351-442 34 1.2e-15 53.56 Pfam 180-270 (270) Show / Hide 
Range on Protein: 351-442
Range on HMM: 180-270/270
Sequence Identity: 34% (32 aa)

WMAPEALQKSPEEMNARSADMWSFAILIWELVTRE-VP-FAGMSSMEVGMKIVGEGLRIDVPPGSSPHMSKLIKICMNEDSTKRPRFDMIMPIL
|||||... .         | ||| .|.||..|.   | ..|||  ||  .|  .| | . |.. .. . .|.| |...|  .||.|  |  .|
WMAPECINYGK---FTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase ILK.AA TK 351-442 22 1.8e-15 47.57 In-house 351-486 (486) Show / Hide 
Range on Protein: 351-442
Range on HMM: 351-486/486
Sequence Identity: 22% (31 aa)

WMAPEALQKSP------EEMNARSADMWSFAILIWELVTRE-VPFAG-MSS---------MEVGMKIV-------------GEGLRIDVPPGSS------
|||||.|..        .       |.||| .|.||..|.  .|..| ||.          ||  ...             |...|   ||. .      
WMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYR

--------PHMSKLIKICMNEDSTKRPRFDMIMPIL
        . .  |.. | ..|  .||.|. .   |
MHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase ILK.AA TyrKc 191-442 23 2.8e-15 24.32 SMART 1-280 (280) Show / Hide 
Range on Protein: 191-442
Range on HMM: 1-280/280
Sequence Identity: 23% (71 aa)

VKLQSKINSSPTGDMWKGIWQGTAVMAKVLKVTNVTSRISREFGEEFPRLRIF--SHPNIHPVLGCVNQP-------PNLVVLSETLQHGSLFHVLHEAS
..|  |. .   |  .||.|  . |  |.||         ..| .|   .. .  .||||   .|.. |.       . | .. |   ||.| . |..  
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

GIVVDHGQMVSFALDIARGMSFLHAMDPLIPRYYLNSK---------NIMIDEELTAKI-------NMGDT--------RFSFQN--RAKF-FNPAWMAP
.  . . ...||...||.||..|| .           .         |....|..|.||       . .|           . .    .|. .   ||||
PK-LCMKDLLSFCWQIACGMEYLHSK-----------NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAP

EALQKSPEEMNARSA------DMWSFAILIWELVTR-EVPFAG-----MSSMEVGMKIVGEGLRIDVPPG--------SSPHMSKLIKICMNEDSTKRPR
|..         .        | ||| ...||. |. . |  |     ||  || .. | .| | . ||          .. | ...| | .||  .||.
ECI---------NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEV-IEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPT

FDMIMPIL
|  |  ..
FSEIHECF
Kinase ILK.AA TK 191-307 12 2.3e-12 36.96 In-house 1-253 (486) Show / Hide 
Range on Protein: 191-307
Range on HMM: 1-253/486
Sequence Identity: 12% (32 aa)

VKLQSKINSSPTG---DMWKGIWQG---------------------------TAVMAKVLKVT-NVTSRISRE--------------FGEEFPRLR--IF
..|  |. .   |   . .||.|.|                           | |  |.|| . . ...  ..              . ||   ..  ..
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

SHPNIHPVLGCVNQP------------PNLVVLSETLQHGS----LFHVLHEASGI--------------------------------------------
 ||||   .|.. |.            . . .. |  .||.    | . |.. ..                                             
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

------------------------------VVDHGQMVSFALDIARGMSFLHAM
                               ..  |.. ....||.||..||..
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSK
Kinase ILK.AA S_TKc 191-442 19 6.2e-12 -1.88 SMART 1-231 (231) Show / Hide 
Range on Protein: 191-442
Range on HMM: 1-231/231
Sequence Identity: 19% (54 aa)

VKLQSKINSSPTGDMWKGIWQG--TAVMAKVLKVTNVTSRISREFGEEFPRLRIFSHPNIHPVLGCVNQPPNLVVLSETLQH--GSLFHVLHEASG----
 ..  || .   |  .|... .    |  |..|         . .  |   |.   ||||   ...     .| .  | . .  |.||.....  .    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

IVVDHGQMVSFALDIARGMSFLHAMDPLI-----PRYYLNSKNIMIDEELTAKI-NMGDTRFSFQNRAKFFNPAWMAPEALQKSPEEMNAR-SADMWSFA
 . .  .  ...  |.... ..| .   |     |       ||..||  . ||   |  |.    .     | .|||| |         . ..|.||. 
FPFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPE------NILLDE--HIKICDFGLARQL---TTFCGTPWYMAPEVL------GYGKCKCDWWSCG

ILIWELVTREVPFAGMSSMEVGMKIVGEGLRIDVPPGSSPHMSKLIKICMNEDSTKRPRFDMIM---------PIL
....|..... ||     |.. .|..|           || .  .|. |.. | .|||    ..         | .
CILYEMLCGYPPFP---QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase ILK.AA Pkinase 349-433 24 1.1e-08 31.75 Pfam 175-282 (293) Show / Hide 
Range on Protein: 349-433
Range on HMM: 175-282/293
Sequence Identity: 24% (27 aa)

PAWMAPEALQKSPEEMNARSADMWSFAILIWELVTREVPFAGM------SSMEVGMKIVGEGLRIDVPPGSS-------------------PHMSKLIKI
| .|||| ..    ..  ...||||. ....|..... || |       . |..  .| |  |. | |  .|                   . . ..|| 
PWYMAPEVIR--GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKW

CMNEDSTKRP
| . | .|||
CLCKDPKKRP
Kinase ILK.AA Dicty4 207-331 28 1.3e-08 24.99 In-house 17-155 (277) Show / Hide 
Range on Protein: 207-331
Range on HMM: 17-155/277
Sequence Identity: 28% (39 aa)

KGIWQGTAVMAKVLKVTNVT--SRISREFGEEFPRLRIFSHPNIHPVLGCVN----QPPNLVVLSETLQHGSLFHVLHE-----ASGIVVDHGQMVS---
||.| |..|  |.|. .|..  . .  ||  |   .   .||||   .|  .    .|. ..  .| .  |.|. .||       . |  | . . .   
KGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQSIKLDWPLIKRAMR

FALDIARGMSFLHAMDPLIPRYYLNSKNIMIDEELTAKI
 |.|.||||  ||. .| |    | | |...|. ...|.
MAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKV
Kinase ILK.AA Pkinase_Tyr 206-307 21 7.1e-07 23.91 Pfam 16-130 (270) Show / Hide 
Range on Protein: 206-307
Range on HMM: 16-130/270
Sequence Identity: 21% (25 aa)

WKGIWQ------GTAVMAKVLKVTNVTSRI--SREFGEEFPRLRIF-SHPNIHPVLGCVN--QPP-NLVVLSETLQHGSLFHVLHEA--SGIVVDHGQMV
.||.|       .. |  |.||  . ...   ...| .|   .. . .||||   .|..   . | .. .  |  .||.| . |..   ..  ... ...
YKGTWKGDPDNTKIPVAVKMLKE-GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLL

SFALDIARGMSFLHAM
.....||.||..|...
QMCWQIAKGMEYLESK
Kinase ILK.AA MLK 191-326 27 2e-06 17.16 In-house 1-139 (280) Show / Hide 
Range on Protein: 191-326
Range on HMM: 1-139/280
Sequence Identity: 27% (39 aa)

VKLQSKINSSPTGDMWKGIWQGTAVMAKVLKVTNVTSRISR-EFGEEFPR----LRIFSHPNIHPVLGCVNQPPNLVVLSETLQHGSLFHVLHEASGIVV
.|..  | .   |  ... |.|  |  |  . .      .  |  |.  .    .   .||||   .|   ..|.|  . |  . |||  |.  .    .
LKIKEIIGNGGFGKVYRAQWKGEEVAVKAHRQDPEQDMQQTDEQAEQVRQEARLFWMLKHPNIIALRGVCLEDPHLCLVMEYCRGGSLNRVCAGK---RI

DHGQMVSFALDIARGMSFLHAMD--PLIPRYYLNSKNIMIDEE
  . .|  |  ||||| .||     |.| |  | |.||.| |.
PPHVLVNWAVQIARGMNYLHNEAPVPIIHR-DLKSSNILILEK
Kinase ILK.AA Pkinase 206-307 19 2e-06 24.2 Pfam 16-127 (293) Show / Hide 
Range on Protein: 206-307
Range on HMM: 16-127/293
Sequence Identity: 19% (22 aa)

WKGIWQGTA--VMAKVLKVTNVTSRISREFGE--EFPRLRIFSHPNIHPVLGCVNQPPNLVVLSETLQHG----SLFHVLH-EASGIV-VDHGQMVSFAL
.|....||   |  |..|. .  |   ..     |   .. ..||||   ....  .... .  | ...|    .||.... ...| .  .  .  ....
YKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMY

DIARGMSFLHAM
 |.||. ..|.|
QILRGLEYCHSM