Gene LRRKd (Sea Urchin)

LRRKd

Species: Sea Urchin
Alias: LRRKd, Spk079, SPU_023309
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: TKL
Family: LRRK

Sequence

Name Sequence Type Origin Length Description Download
LRRKd.AA Protein None 1119 None Fasta, JSON
LRRKd.kin_dom Protein Kinase Domain None 322 None Fasta, JSON

Protein domain

Protein domains of LRRKd.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
COR LRRKd.AA COR 1-385 16 2.2e-17 52.63 In-house 22-434 (434) Show / Hide 
Range on Protein: 1-385
Range on HMM: 22-434/434
Sequence Identity: 16% (76 aa)

VPQPYFNLKKRISEEVEVRQKADPPILPIMTKTELADDIVKLIPDS------GLRTPIELQEAILFLHEIGSIVHFT--DHLNGLNDLYFIDPVWLACTL
||| .. .|. . |. . .. .  .  | |...|....  .  | .       .  . ||. .. .||. |.|.||   ||  .|.|....|| |..  .
VPQSWWKCKQKLEEMRKWMNRH--NEKPWMSWKEFCQICQEHGPPKRLRHQNIIIDEDELHTVAMYLHDLGHIIHFKIWDHDPMLKDFVVLDPQWFCQMM

QRVTALPIGS-----LKGGK-VHVETLRELSKKS----------SIEEDKFEQYLQLLARFEIVVPISHHW----------YLVPARLPRDNPGVM-LSP
 ..             ..|. .... | .. ...            .    |....|. .||. .||.  |          ||.|..|| |.|.   .. 
YHIFNHKESRCFHKLHNKGIFFTHQDLEKIWNPPCRHNPHMNWRRYPDHDHEYLVELMEKFELCYPIDPDWTHFWHQETTTYLIPQLLPDDRPQHWEWWQ

HNT---DDAPFHYLRRIYKM------PYLPPGFWIRLVSRLIADLQMRDKKKKISSAGNERNLGSSKRLTDDEMFPFQRKSSISEAISFHQTESIYWREG
 .     ..   ||||.|..      ..||.||| |.  ||   ... . |                                  .  . ..|. ||| |
WPQWETNEHDCRYLRRHYHYCMDHHHMFLPAGFWPRFQVRLH-HFIHDMFKC---------------------------------FYERSCCEWMYWRNG

IFFRHNTG---QILVRSMVFPSTDKSPGVDILISCQEG-----HFSAMGCVVDQIEGLIKDWY--PGLCTSIHESIQPKVQRLVPCPICVIHGPDDFEPV
... .. .   ..|| . .     .  . .| .. ..      .   .. . . |... ..|.  |||     .    ..  ..||| |          .
MVLKWEGHNKNEALVKCDN-----HDNKIYITVRGCQDCWIDMCCQLWQIIRQHIQHIHNSWWPWPGLQYQCQHW---VCREWIPCPHC----------I

TEDLP-HCY--T--VEELAQTYVRGETHITACANSKE------------------------KPI-TISV
.....  |.  .   .....  ..|.   .  .. ..                        ..|  || 
QDHWDTCCDICYYQYDWCIRAEEMGM--DSYPCPKCDQYCDAFEMMCCYQHHWHYSHDQNGQWIQRISD
Kinase LRRKd.AA LRRK 409-727 34 7.6e-164 550.61 In-house 1-351 (351) Show / Hide 
Range on Protein: 409-727
Range on HMM: 1-351/351
Sequence Identity: 34% (124 aa)

MVSGQSLGQGGFG-EVFRAKFRGETVAAKTMLPSRLLKNRMFSSASEGYASCASTSSSTSNRTGESTSTEND---------------------SLEAAML
.......|.|||| .|.|||.||..|....|....|... |...|...|..|...  .. ||... |.. ||                     .......
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPY-MYQGARNSYDMCQWVAIKKWNRDPM-TID-NDCNNSNNNNNLNNNNSEQVEDMDQNHEDC

MESFHKLRNEVAIMAKLDHPYIVNLVGVSIRHLCFAMDYAPLGDLRSYLFAEHQSARPHFVKRNIVLEPVLSRMLTYKISLQVASAVGYLHRKD--IIYC
...|...|.||.|| .|.||.||.|.|..|..||..|.|||.||| ..|....|... ||.|      ...|.||..||.||.|....|||...  ||..
CRAFREFRHEVWIMSHLNHPNIVSLKGFCIHPLCMVMEYAPHGDLYHFLHNKKQDGF-HFMK------AHISWMLKLKIALQIAKGMEYLHSHNPPIIHR

DLKTDNILLFSSD-------VNEDVNIKLIDYGISK--KYDLMG-AMGMAGTPGFCAPEILQG---KTFDEKVDWFSYGMFLYHLMTGLVPYYDQHS---
|||..||||.||.       .|..|..|..|.|||   ....|| |.|. |.||..||||...   ....||||..|.||.|..|.|......|.|.   
DLKSPNILLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFD

----RIEIELAVNEGRKPTFNFHEYTMPPKQVFPALGALMESCWQNKPGERPHGETTLQLLSE
    ...||....||..||...| | .||.|... . .|...|||..| .||| .. .. ||.
HMQWMEQIEDKIIEGLRPTIPQH-Y-CPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase LRRKd.AA TKL 415-725 20 6.7e-75 255.15 In-house 1-364 (364) Show / Hide 
Range on Protein: 415-725
Range on HMM: 1-364/364
Sequence Identity: 20% (85 aa)

LGQGGFGEVFRAKFRG----------ETVAAKTMLP------------------SRLLKNRMFSSASEGYASCASTSSSTSNRTGESTSTENDSLEAAML
.|.||||||...|.||          ..|| |..                    .                                 |  . .|.. ..
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNY---------------------------------SD-M-QLNDPEA

MESFHKLRNEVAIMAKLDHPYIVNLVGVSIRH---------------LCFAMDYAPLGDLRSYLFAEHQSARPHFVKRNIVLEPVLSRMLTYKISLQVAS
.  . ....|. .| .|.|| || ..|....                ||. |.|.| |.|..||                         .. ...|..|.
SWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH----------------------WHQRCRWALDIAR

AVGYLHRKD--------IIYCDLKTDNILLFSS---------DVNEDVNIKLIDYGISKKYDLMG---------------------AMGMAGTPGFCAPE
.. ||| ..        ||..|||..|||...          ..|.|...|. |.|.|.  . .|                      |   |||...|||
GMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPE

ILQGK----------------TFDEKVDWFSYGMFLYHLMTGLVPYYDQHSR---------IEIELAVNEGRKPTFNFHEYT----MPPKQVFPALGALM
.|.|.                ...||.| .|.|. |. ..|. .||||....         .........|..|.   .  .    .|.... | .  ||
VLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLM

ESCWQNKPGERPHGETTLQLL
. ||. .| .||  .. |. |
QDCWDHDPEKRPSFQEILKRL
Kinase LRRKd.AA AGC 409-672 17 1.4e-47 119.96 In-house 1-323 (395) Show / Hide 
Range on Protein: 409-672
Range on HMM: 1-323/395
Sequence Identity: 17% (68 aa)

MVSGQSLGQGGFGEVFRAKFR--------GETVAAKTMLPSR-LLKNR--MFSSA-SE------GYASCASTSSSTSNRTGESTSTENDSLEAAMLMESF
      .|.|.||.|. .. .        |.  | | .  ..  ....  |   . .|      ||                                  
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGY----------------------------------

HKLRNEVAIMAKLD----------HPYIVN-LVGVSIR--H--LCFAMDYAP--------LGDLRSYLFAEHQSARPHFVKRNIVLEPVLSRMLTYKISL
  ...|  |..|..          ||.||. |        |  |.| |.|.|         |.. ..|   ..        |    | ...   .  .  
--VWEERNILEKCNHTHNHPIKSHHPFIVKILHYSFQDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGR--------R---KEGRFDEERARFYAA

Q-------VASAVGYLHR-KDIIYCD-LKTDNILLFSSDVNEDVNIKLIDYGISKKYDLMG---------------------------------------
.       ...|. |||. ..||. | || .|||| .       .||| | | .|.    |                                       
EMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDED-----GHIKLTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNM

-------------AMGMAG--TPGFCAPEILQGKTFDEKVDWFS--YGMFLYHLMTGLVPYYDQH---------SRIEI
             .  . |  || . |||||     .  .|| |  .| ..| ..||. |.|..          .. |.
SQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEM
Kinase LRRKd.AA Pkinase 409-716 19 3.3e-47 167.94 Pfam 1-282 (293) Show / Hide 
Range on Protein: 409-716
Range on HMM: 1-282/293
Sequence Identity: 19% (66 aa)

MVSGQSLGQGGFGEVFRAKFRGET--VAAKTMLPSRLLKNR------MFSSASEGYASCASTSSSTSNRTGESTSTENDSLEAAMLMESFHKLRNEVAIM
 . |. .|.|.||.|.... .|.   || |..  ..  ..                                                      .|..||
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL----------------------------------------------SEIQIM

AKLDHPYIVNLVGVSI--RHLCFAMDYAPLG----DLRSYLFAEHQSARPHFVKRNIVLEPVL--SRMLTYKISLQVASAVGYLHRKDIIYCDLKTDNIL
..|.||.|| | ..    .|... |.|.. |    || .|. .                . ..  |     .. .|..... |.|.. ||..||| .|||
KRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST--------------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENIL

LFSSDVNEDVNIKLIDYGISKK--YDLMGAMGMAGTPGFCAPEILQ-GKTFDEKVDWFSYGMFLYHLMTGLVPYYDQ---HSRIEIELAVNEGRKPTFNF
. . .....  .|..| |..|.  |   .... .|||...|||... |.  . |||..|.|  || ...|  |....   .. ..    ... ..| . |
IDNNGHIDA-CVKICDFGLAKQFDY-NNSMTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHF

HEYTMPPKQVF---------------PALGALMESCWQNKPGERP
....  ..  |               ...  ....|.. .| .||
DWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRP
Kinase LRRKd.AA S_TKc 409-730 21 1.3e-42 148.75 SMART 1-231 (231) Show / Hide 
Range on Protein: 409-730
Range on HMM: 1-231/231
Sequence Identity: 21% (71 aa)

MVSGQSLGQGGFGEVFRAKFRG--ETVAAKTMLPSRLLKNRMFSSASEGYASCASTSSSTSNRTGESTSTENDSLEAAMLMESFHKLRNEVAIMAKLDHP
   .. .|.|.||.|.... ..  . || | .                                                     ..|.|..|. | .||
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------------------------------------------------EHIRREIQILKK-HHP

YIVNLVGVSI-RHLCFAMDYAPL--GDLRSYLFAEHQSARPHFVKRNIVLEP-VLSRMLTYKISLQVASAVGYLHRKDIIYCDLKTDNILLFSSDVNEDV
.||.| .|    ||.. |.|..   |||..|.           .||.    . ...   . ..  |...|. |.|.. ||..||| .|||| .       
NIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYI-----------KKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-------

NIKLIDYGISKKYDLMGAMGMAGTPGFCAPEILQGKTFDE-KVDWFSYGMFLYHLMTGLVPYYDQHSRIEIELAVNEGRKPTFNFHEYTMPPKQVFPALG
.||..| |.....     . . ||| ..|||.|    ..  |.|| | |  || ...|  |..  .    ... .                     | . 
HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG--------------------SPEAK

ALMESCWQNKPGERPHGETTLQ----LLSEPSF
 ... |.|  | .||     ||      . | |
DFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase LRRKd.AA Ciliate-E2 409-730 18 2.5e-37 125.69 In-house 1-365 (365) Show / Hide 
Range on Protein: 409-730
Range on HMM: 1-365/365
Sequence Identity: 18% (80 aa)

MVSGQSLGQGGFGEVFRA-------------------------KFRGETVAAKTMLPSRLLKNRMFSSAS-----EGYASCASTSSSTSNRTGESTSTEN
    . .|||.|| |...                         |. .  .| |.| .. .    .  .       .                        
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCF------------------------

DSLEAAMLMESFHKLRNEVAIMAKLDHPYIVNLVGVSI----RHLCFAMDYAPLGDLRSYL------FAEHQSARPHFVKRNIVLEPVLSRMLTYKIS--
           . |. ||  |. .|.||.|.... . .     .. . |.|.  |||..|.      . ....            .    ..  ..|.  
-----------YKKI-NEKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIE------------K-D-KYFTEKEIKYI

-LQVAS---------------AVGYLHRKD-IIYCDLKTDNILLFSSDVNEDVNIKLIDYGISKKYDLM-------GAMG--------------------
  |...               |. ||| |  ||. |.| .|||.          ||.|| |.|||||           ..                    
MKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQ

------MAGTPGFCAPEILQGKT---------FDEKVDWFSYGMFLYHLMTGLVPYYDQHSRIEIELAVNEGRKPTFNFHEYTMP----------PKQVF
       .||||. |||||.||           |.|.|..| |. || ...|  |.          .  ..  |  |.. |.. .          .|.. 
QNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF----------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWS

PALGALMES----CWQNKPGERPHGETTLQLLSEPSF
.    |.      . | .| .|.      |.|  | |
QECKDLIKKFGKRMLQKDPEKRIT--GWEQILNHPWF
Kinase LRRKd.AA Ciliate-E2-Unclassified 499-730 21 3.7e-28 94.76 In-house 74-352 (352) Show / Hide 
Range on Protein: 499-730
Range on HMM: 74-352/352
Sequence Identity: 21% (66 aa)

IMAKLDHPYIVNLVGVSI--RHLCFAMDYAPLGDLRSYL----------------------FAEHQSA---RPHFVKRNIVLEPVLSRMLTYKISLQVAS
|.  ..||.||... .     .... |.|.. |||. |.                      | | |..                        ..  |. .
ILLNHPHPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKA-------------------KFYFAQILQ

AVGYLHRKD-IIYCDLKTDNILLFSSDVNEDVNIKLIDYGISKKYDL-----------------MGAMGMAGTPGFC----APEILQGKTFD----EKVD
.  |||.|  ||. |.| .|||. ..      .||.||.||||||.                  . .  ..|||..     |||.|||.  |    .|.|
GLEYLHHKNNIIHRDIKPENILFDNNGK--NYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCD

WFSYGMFLYHLMTGLVPYYDQHSRI---------------EIELAVNEGRKPTFNFHE----YTMPPKQ---VFPALGALMESCWQNKPGERPHGETTLQ
..| |. || ...|  |.||. . .               ...   ...    ..| .    .. .|..   .      |. .. ...|..|.   |  |
IWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFIN----DLLQKMLKKNPNKRI---TFEQ

LLSEPSF
.|  | |
ILNHPWF
Kinase LRRKd.AA TK 409-725 15 9.2e-28 89.52 In-house 1-486 (486) Show / Hide 
Range on Protein: 409-725
Range on HMM: 1-486/486
Sequence Identity: 15% (80 aa)

MVSGQSLGQGGFG---EVFRAKFRG---------------------------ETVAAKTMLPSRLLKNRMFSS------ASEGYASCASTSSSTSNRTGE
 . |. ||.| ||   ||.... ||                           ..|| |.. .      ..|        . .|                 
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRD-GG-----------------

STSTENDSLEAAMLMESFHKLRNEVAIMA--KLDHPYIVNLVGVSIRH--------------LCFAMDYAPLGD----LRSYLFAEHQSARPHFVKRNIV
               | | .. .| ..|   ...|| ||.|.||. ..              ..  | |.|.||    ||.|| . .  ....  .   .
---------------EDFLEEAEEMKMMCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQ

LEPV----------------------------------------LSRMLTYK-------------------ISLQVASAVGYLHRKDI------IYCDLK
 ...                                        |.    .                    ...|.|..  |||.| .      .  || 
HNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLA

TDNILLFSSDV------NEDVNIKLIDYGIS--------------KKYDLMGAMGMAGTPGF-----------------------CAPEILQGKT-----
. |.|.....|      .    .|. |.| |              . |  ..  |... .                         .||| |....     
ARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPM-WPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAE

----FDEKVDWFSYGMFLYHLMT-GLVPYYDQHSR---------IEIELAVNEGRKPTFN--FHE-----YTMPPKQVFP--------------ALGAL-
    | .| | .|.| ... ..| | .||| ..|           |.   . .|... .   . .     . ||. .  |              .. .. 
KYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRL-CRSGL-NEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDL

MESCWQNKPGERPHGETTLQLL
| .||. .| .||  .. .. |
MQQCWHYDPEDRPTFSQLHEQL
Kinase LRRKd.AA MLK 488-725 26 6.3e-24 79.97 In-house 50-291 (291) Show / Hide 
Range on Protein: 488-725
Range on HMM: 50-291/291
Sequence Identity: 26% (67 aa)

ESFHKLRNEVAIMAKLD-HPYIVNLVGVSIRH---LCFAMDYAPLGDLRSYLFAE--HQSARPHFVKRNIVLEPVLSRMLTYKISLQVASAVGYLHRKD-
. | .  ....|. ..  ||.|. ..||....   .|  | |.. | | ..| ..  . ... |  | | .   | .  .  ...||.|... ||| .. 
WDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNVLHGARSKWMDANHNQK-NDR---VYDHDHAMNWALQCARGMHYLHSMAP

--IIYCDLKTDNILLF---SSDVNEDVNIKLIDYGISKKYDLM-G-AMGMAGTPGFCAPEIL---QGKTFDEKVDWFSYGMFLYHLMTGLVPYY-DQHSR
  ||  |||  |||.    . | ....  |  | |.|..   |    |..|||. . |||..   .. ...||.| .|.|. |. ..|. |||  .. . 
KPIIHRDLKSHNILIDEICH-DMHHGT-LKICDFGTSRDWHQMCTNMMSNAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPM

IEIELAVNEGRKPTFNFHEYTMPPKQVFPALGALMESCWQNKPGERPHGETTLQLL
  .  ....|  |.   ...| |.      .  ||. ||. .|..||     .| |
AIAWWVAYNGLRPP---IPSTCPEH-----WKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase LRRKd.AA Dicty4 575-663 32 1e-21 69.35 In-house 127-217 (277) Show / Hide 
Range on Protein: 575-663
Range on HMM: 127-217/277
Sequence Identity: 32% (31 aa)

YLHRKD--IIYCDLKTDNILLFSSDVNEDVNIKLIDYGISK----KYDLMG-AMGMAGTPGFCAPEILQGKTFDEKVDWFSYGMFLYHLMTGLVPY
.||  .  ||  |||..|.|     | .. ..|  | |.|.      |.   .|...|||.  |||..... ..||.| .|.|. |. . |.  ||
WLHCCNPVIIHRDLKSHNLL-----VDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKADVYSFGIVLWEILTRQEPY
Kinase LRRKd.AA CAMK 568-665 27 2e-19 58.57 In-house 187-336 (425) Show / Hide 
Range on Protein: 568-665
Range on HMM: 187-336/425
Sequence Identity: 27% (41 aa)

QVASAVGYLHRKDIIYCDLKTDNILLFSSDVNED------------VNIKLIDYGISKKYDLMG-------------------------AMGMAGTPGFC
|..||| |.| ..|. .||| .|||| ... ..|             |||.|| | ..|.|                               . |||...
QICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYM

A-PEILQGKT--------------FDEKVDWFSYGMFLYHLMTGLVPYYD
| ||.|.||.               ..|.|  | |  || . .|  |.|.
AAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYG
Kinase LRRKd.AA TKL-Unique 563-663 27 5.1e-18 60.27 In-house 113-234 (290) Show / Hide 
Range on Protein: 563-663
Range on HMM: 113-234/290
Sequence Identity: 27% (33 aa)

YKISLQVASAVGYLHRKD--IIYCDLKTDNILLFSSDVNEDVNIKLIDYGISKKYD--LMGAMGMA---------GTPGFCAPEILQG--KTFDEKVDWF
.|. ...|..  |||...  || .|||. |.|. .      .|||..| |.||  .  . .  ..          |..   |||.| .  ....||.| .
VKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQYSEKSDVY

SYGMFLYHLMTGLV------PY
|.|. |. . |. .      ||
SFGIVLWEIATRKITKTYKKPY
Kinase LRRKd.AA TyrKc 409-725 20 1.5e-17 61.04 SMART 1-280 (280) Show / Hide 
Range on Protein: 409-725
Range on HMM: 1-280/280
Sequence Identity: 20% (73 aa)

MVSGQSLGQGGFGEVFRAKFRGETVAAKTMLPSRLLKNRMFSSASEGYASCASTSSSTSNRTGESTSTENDSLEAAMLMESFHKLRNEVAIMAKL--DHP
 . |. || | ||||.... . ..|| |.. ..                                                   ...|  || ||  .||
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-----------------------------------------------REDFMREARIMCKLGGHHP

YIVNLVGVSI---------RHLCFAMDYAPLGDLRSYL-FAEHQSARPHFVKRNIVLEPVLSRMLTYKISLQVASAVGYLHRKDIIYCDLKTDNILLFSS
 ||.|.|| .           |.  | |.|.|||..||   ...                |.     ....|.|.   |||.| .|  || . |.|. . 
NIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK----------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGEN

DVNEDVNIKLIDYGISKKYDLM------GAMGMA----GTPG-----FCAPEILQGKTFDEKVDWFSYGMFLYHLMT-GLVPYYDQ----HSRIEIELAV
       .|  | | |.. .        . . ..    |. .      .||| .. ..| .| | .|.|  .. ..| |  ||...     | .|.   |
H-----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYV

NEGRKPTFNFHEYTMPPKQ----VFPALGALMESCWQNKPGERPHGETTLQLL
 .|. .    . |   |        ...  .|..||. .| .||  ..  ...
KQGYRMPQPPNDY---P-MSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase LRRKd.AA Pkinase_Tyr 487-582 25 2e-12 42.73 Pfam 41-133 (270) Show / Hide 
Range on Protein: 487-582
Range on HMM: 41-133/270
Sequence Identity: 25% (27 aa)

MES---FHKLRNEVAIMAKL-DHPYIVNLVGVSI---RH--LCFAMDYAPLGDLRSYLFAEHQSARPHFVKRNIVLEPVLSRMLTYKISLQVASAVGYLH
|..     .. .|..|| .| .|| ||.|.|| .   ..  ..  | |.|.|||..|| .                .. |.     ....|.|..  ||.
MHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHR------------EDKQPLTMKDLLQMCWQIAKGMEYLE

RKDII
.| .|
SKNCI
Kinase LRRKd.AA CAMK 414-543 16 3.2e-11 31.68 In-house 1-183 (425) Show / Hide 
Range on Protein: 414-543
Range on HMM: 1-183/425
Sequence Identity: 16% (33 aa)

SLGQGGFGEVFRAKFRGET--------------VAAKTMLPSRLLKNRMFSSASEGYASCASTSSSTSNRTGESTSTENDSLEAAM-----LMESFHKLR
 ||.|.||.|.... .  |              ||.| .  ..| ..   ..      .               ..   |  .. .       .. ...|
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQN-QDY-S---N---------------CY-KIDKSKCKHRYCWRRPKDRKNVR

NEVAIMAK-------LDHPYIVNLVGV--------------SIRH--------LCFAM---DYAPLG----DLRSYL--------------------FAE
.|..|| |       |||| |..|  |              . ..        ... |   .|.. |    || .|.                    | |
REIEIMKKLQGIGNKLDHPNIIKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTE

HQSAR
.. .|
REARR
Kinase LRRKd.AA TKL-Unique 492-535 35 9.8e-10 30.69 In-house 41-91 (290) Show / Hide 
Range on Protein: 492-535
Range on HMM: 41-91/290
Sequence Identity: 35% (18 aa)

KLRNEVAIMAKLD-HPYIVNLVGVSI------RHLCFAMDYAPLGDLRSYL
...||| .| ||. || || ..|...       ..|. |.| |.| |...|
EFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVL
Kinase LRRKd.AA Dicty4 409-436 42 4.7e-07 19.75 In-house 1-28 (277) Show / Hide 
Range on Protein: 409-436
Range on HMM: 1-28/277
Sequence Identity: 42% (12 aa)

MVSGQSLGQGGFGEVFRAKFRGETVAAK
 . .| .|.|.||||.... ||  || |
INIEQRIGKGSFGEVYKGTWRGKEVAVK
Kinase LRRKd.AA MLK 409-437 27 4e-06 17.4 In-house 1-29 (291) Show / Hide 
Range on Protein: 409-437
Range on HMM: 1-29/291
Sequence Identity: 27% (8 aa)

MVSGQSLGQGGFGEVFRAKFRGETVAAKT
    . .| |.||.|.....|.... ||.
IQFHEWIGSGSFGKVWKGRWRNKDIVAKI
Kinase LRRKd.AA TKL-Unique 411-437 40 8e-06 16.67 In-house 1-27 (290) Show / Hide 
Range on Protein: 411-437
Range on HMM: 1-27/290
Sequence Identity: 40% (11 aa)

SGQSLGQGGFGEVFRAKFRGETVAAKT
 . ..|.||.|.|...|.||. || |.
FWNKIGEGGYGQVYKGKWRGYPVAIKQ
Kinase LRRKd.AA Dicty4 493-513 47 0.000697 9.03 In-house 45-65 (277) Show / Hide 
Range on Protein: 493-513
Range on HMM: 45-65/277
Sequence Identity: 47% (10 aa)

LRNEVAIMAKLDHPYIVNLVG
.|.||.||.|. || |. . |
FRKEVHIMCKIRHPNICLFMG
Kinase LRRKd.AA Pkinase_Tyr 409-441 28 0.003037 11.61 Pfam 1-39 (270) Show / Hide 
Range on Protein: 409-441
Range on HMM: 1-39/270
Sequence Identity: 28% (11 aa)

MVSGQSLGQGGFGEVFRAKFR------GETVAAKTMLPS
 . |. ||.| ||||.... .      . .|| |.. ..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEG
Kinase LRRKd.AA Ciliate-E2-Unclassified 410-427 38 0.076079 2.21 In-house 2-19 (352) Show / Hide 
Range on Protein: 410-427
Range on HMM: 2-19/352
Sequence Identity: 38% (7 aa)

VSGQSLGQGGFGEVFRAK
  .. .||||||.|....
KIIKQIGQGGFGKVYKCQ
Kinase LRRKd.AA Dicty4 693-716 33 0.085729 1.96 In-house 241-264 (277) Show / Hide 
Range on Protein: 693-716
Range on HMM: 241-264/277
Sequence Identity: 33% (8 aa)

PKQVFPALGALMESCWQNKPGERP
|... | . .|.. || . |  ||
PDWCPPSWKHLIQWCWDHDPQHRP
Kinase LRRKd.AA Pkinase_Tyr 630-680 27 0.288926 4.91 Pfam 181-233 (270) Show / Hide 
Range on Protein: 630-680
Range on HMM: 181-233/270
Sequence Identity: 27% (15 aa)

CAPEILQGKTFDEKVDWFSYGMFLYHLMT-GLVP-YYDQHSRIEIELAV-NEGR
.||| .. . | .| |  |.|  .. ..| |  | |..  |  |.  ..  .|.
MAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGM-SNEEVYEYIYEDGY
Kinase LRRKd.AA Pkinase_Tyr 703-716 50 0.374099 4.53 Pfam 248-261 (270) Show / Hide 
Range on Protein: 703-716
Range on HMM: 248-261/270
Sequence Identity: 50% (7 aa)

LMESCWQNKPGERP
|| .||. .| .||
LMKQCWHYDPEDRP