Gene TK5 (Sea Urchin)
TK5
Sequence
Protein domains of TK5.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | TK5.AA | TK-Unique | 34-164 | 35 | 9.1e-49 | 166.29 | In-house | 1-153 (294) | Show / Hide |
Range on Protein: 34-164 Range on HMM: 1-153/294 Sequence Identity: 35% (54 aa) FTRLGSIGRVDFGGVWKGELR------SKQSQVDVDIRQIPDQVTKSKNVSEAVKVLSELPDHPNVVKCMGYCQ---EQGSILYEFISGGTLLTHLQTTG .. . .||. || ||.||.. .||..| | .... . |. .. ....||.||||.|.|.|.|. |. |..|....|.|...|.|.. LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR -VQSQP-TYGNLK------PERVR---IDEGSLLNLAWQIAKGMQYLAS--KK ...|. |||||| |...| |....|.. |||||.||.|||| || PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKK |
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| Kinase | TK5.AA | TK-Unique | 166-247 | 36 | 5.6e-25 | 83.15 | In-house | 199-294 (294) | Show / Hide |
Range on Protein: 166-247 Range on HMM: 199-294/294 Sequence Identity: 36% (35 aa) PTRWSSPETMV--TGDQ-STEGDNWSF----------GARPYPKMTFDTVQKEVANGYQMPRPRHC-GQEVYSVMSGCWEKEATRRSNFDQILKSL | || .|| . .| .|..| ||| ||.|||.| . ..... .|| ||.| || .|.|..|. || .|.. |..|.||.. | PIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL |
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| Kinase | TK5.AA | TK | 34-164 | 14 | 1.1e-22 | 72.18 | In-house | 1-254 (486) | Show / Hide |
Range on Protein: 34-164
Range on HMM: 1-254/486
Sequence Identity: 14% (38 aa)
FTRLGSIGRVDFG---GVWKGELRSK-----------------------QSQVDVDIRQIPDQVTKSKN-VSE-----------------AVKVLSE-LP
| . .|. || |.|||.|.. . ...| . .. . . |.. . . |.... |
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG
DHPNVVKCMGYCQEQG--------------SILYEFISGGT----LLTHLQTTGV---QSQPTYGNLKPERVR---------------------------
.|||.|.. |.| ... |. |. ..| |...|.. ..|....|... ...
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY
-------------------------------IDEGSLLNLAWQIAKGMQYLASKK
.. || .||||.||.||.||.
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKN
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| Kinase | TK5.AA | Pkinase_Tyr | 34-164 | 24 | 2.8e-18 | 62.51 | Pfam | 1-131 (270) | Show / Hide |
Range on Protein: 34-164
Range on HMM: 1-131/270
Sequence Identity: 24% (35 aa)
FTRLGSIGRVDFGGVWKGELR--SKQSQVDVDIRQIPDQVTKS----KNVSEAVKVLSELPDHPNVVKCMGYCQ-EQGS----ILYEFISGGTLLTHLQT
| . .|. || |.||... .. ...| . .... ... . . .|....|..|||.|...| | .... | |. .| ||..|..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK
TGVQSQPTYGNLKPERVRIDEGSLLNLAWQIAKGMQYLASKK
... ... ||. .|||||||.||.||.
HR-----------EDKQPLTMKDLLQMCWQIAKGMEYLESKN
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| Kinase | TK5.AA | Src | 166-247 | 34 | 5.5e-18 | 57.66 | In-house | 163-255 (255) | Show / Hide |
Range on Protein: 166-247 Range on HMM: 163-255/255 Sequence Identity: 34% (32 aa) PTRWSSPETMVTGDQSTEGDNWSF----------GARPYPKMTFDTVQKEVANGYQMPRPRHCGQEVYS-VMSGCWEKEATRRSNFDQILKSL | .| || | .. | ||| | ||| || | ..| .|| ||.|..| .|.| .| ||.|.. .| |. . . | PIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL |
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| Kinase | TK5.AA | Pkinase_Tyr | 188-247 | 33 | 3.5e-17 | 58.8 | Pfam | 209-270 (270) | Show / Hide |
Range on Protein: 188-247 Range on HMM: 209-270/270 Sequence Identity: 33% (21 aa) SFGARP-YPKMTFDTVQKEV-ANGYQMPRPRHCGQEVYSVMSGCWEKEATRRSNFDQILKSL ..|. | || |. | . . .||.||.|..| .|.|..| ||.... .| | .|. | TYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL |
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| Kinase | TK5.AA | TKL | 40-160 | 20 | 3.6e-17 | 58.37 | In-house | 1-148 (364) | Show / Hide |
Range on Protein: 40-160
Range on HMM: 1-148/364
Sequence Identity: 20% (34 aa)
IGRVDFGGVWKGELR-------SKQSQVDVDIRQIPDQV-------------------------TKSKNVSEAVKVL-SEL-PDHPNVVKCMGYCQEQG-
||. || |.||..| | .. || . ... . . |.. . .... . . .|||.|..||||.. .
IGSGGFGEVYKGKWRGWGGKCPS-DTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPC
--------------SILYEFISGGTLLTHLQTTGVQSQPTYGNLKPERVRIDEGSLLNLAWQIAKGMQYL
| .|...||.|| .|. ....| .||.||.||
GCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH---------------------WHQRCRWALDIARGMNYL
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| Kinase | TK5.AA | UTK | 187-247 | 34 | 6.5e-17 | 54.41 | In-house | 234-296 (296) | Show / Hide |
Range on Protein: 187-247 Range on HMM: 234-296/296 Sequence Identity: 34% (22 aa) WSFGARPYPKMTFDTVQKEVANG--YQMPRPRHCGQEVYSVMSGCWEKEATRRSNFDQILKSL |..|..||| |. . | ..| || |.||.|..|. .|| .| ||... .| .|..... . WTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM |
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| Kinase | TK5.AA | Src-Echino1 | 164-247 | 31 | 1.2e-16 | 53.9 | In-house | 158-252 (252) | Show / Hide |
Range on Protein: 164-247 Range on HMM: 158-252/252 Sequence Identity: 31% (30 aa) KKPTRWSSPETMVTGDQSTEGDNWSF----------GARPYPKMTFDTVQKEVANGYQMPRPRHCGQEVYSV-MSGCWEKEATRRSNFDQILKSL | | .| .|| . | | ||| | |||.|. | ..|..||.||.. || .| . | || |.. .| |. . . . KLPIKWTAPEAALYGRFTIKSDVWSFGILMTEMVTFGRYPYPGMMNREVLDQVDRGYRMPKMHHCPDSLYMMCMMKCWHKDPQQRPTFEFLHDFF |
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| Kinase | TK5.AA | Csk | 187-247 | 39 | 1.5e-16 | 52.98 | In-house | 191-251 (251) | Show / Hide |
Range on Protein: 187-247 Range on HMM: 191-251/251 Sequence Identity: 39% (24 aa) WSFGARPYPKMTFDTVQKEVANGYQMPRPRHCGQEVYSVMSGCWEKEATRRSNFDQILKSL .||| |||.. | | | ||.| | | .|| ||. ||. .. .| | |... | YSFGRVPYPRIPLKDVVKHVEKGYRMEAPEGCPPHVYKVMKQCWHLNPAKRPTFRQVREQL |
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| Kinase | TK5.AA | TK | 187-247 | 20 | 1.6e-16 | 51.14 | In-house | 388-486 (486) | Show / Hide |
Range on Protein: 187-247 Range on HMM: 388-486/486 Sequence Identity: 20% (20 aa) WSFGARPYPK-MTF---------DTVQKEVANG--------------YQMPRPRHCG--------------QEVYSVMSGCWEKEATRRSNFDQILKSL ...|. ||. |. . | . . .| ..||.| || .|.| .| ||.... .| .|.|... | FTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL |
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| Kinase | TK5.AA | TyrKc | 34-247 | 21 | 5.1e-16 | 36.24 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 34-247 Range on HMM: 1-280/280 Sequence Identity: 21% (66 aa) FTRLGSIGRVDFGGVWKGELRSKQSQVDVDIRQIPDQVTKSKNVSEAVKVLSEL-PDHPNVVKCMGYCQ---------EQGSILYEFISGGTLLTHLQTT | . .|. || |.||... ..| . . . . . .....| ..|||.|.. |.| |. |. |. ..| |. .|. . ITLGKKLGEGAFGEVYKGTWK-----IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH GVQSQPTYGNLKPERVRIDEGSLLNLAWQIAKGMQYLASK---------------------------------------------------KK---PTRW . . . ||. .||||.||.||.|| .| | || RPK--------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRW SSPETMVTGDQSTEGDNWSFG----------ARPYPK-----MTFDTVQKEVANGYQMPRPRH--------CGQEVYSVMSGCWEKEATRRSNFDQILKS .||.. .| .|. | |||| . ||| |. . | . | .|| ||.| . | .|.|..|. ||. .. | .| .| . MAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHEC L . F |
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| Kinase | TK5.AA | Fer | 156-248 | 32 | 1.1e-15 | 49.98 | In-house | 168-283 (283) | Show / Hide |
Range on Protein: 156-248 Range on HMM: 168-283/283 Sequence Identity: 32% (38 aa) GMQYL---ASKKKPTRWSSPETMVTGDQSTEGDNWSF----------GARPYPK----MTFDTV----QKE-VANGYQMPRPRHCGQEVYSVMS-GCWEK |..|. ...| |.|| .|||. || |.. | ||| || ||| |. .| .| . .|| || | |. |....| ||.| GYDYKMKEKACKVPIRWLAPETWQTGIYSPKTDVWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQK EATRRSNFDQILKSLE . | ....| . |. DPEDRPTMKEICQKLK |
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| Kinase | TK5.AA | Tie | 188-247 | 38 | 1.4e-14 | 40.17 | In-house | 208-267 (267) | Show / Hide |
Range on Protein: 188-247 Range on HMM: 208-267/267 Sequence Identity: 38% (23 aa) SFGARPYPKMTFDTVQKEVANGYQMPRPRHCGQEVYSVMSGCWEKEATRRSNFDQILKSL |.| || || . . . ||.| .|| | ||| .| || . | | ||. .| SLGGTPYCGMTCAELYEKLPQGYRMEQPRNCDDEVYDLMRQCWRDRPYERPPFAQIAVQL |
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| Kinase | TK5.AA | MLK | 34-167 | 24 | 1.6e-13 | 43.41 | In-house | 1-147 (291) | Show / Hide |
Range on Protein: 34-167 Range on HMM: 1-147/291 Sequence Identity: 24% (37 aa) FTRLGSIGRVDFGGVWKGELRSKQ-SQVDVDIRQIP-------DQVTKSKNVSEAVKVLSELPDHPN----VVKCMGYCQEQGS---ILYEFISGGTLLT .. . || || ||||. | | .. |..... | . .... . .. |. | .||| ... .| |..... |. |...|| | . IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRIL-SHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN HLQTTGVQSQPTYGNLKPERVRIDEGSLLNLAWQIAKGMQYLASKKKPT | . .. . | | ...| ....| | |.|.||.|| |..... VLHGARSKWMDANHNQK-NDRVYDHDHAMNWALQCARGMHYLHSMAPKP |
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| Kinase | TK5.AA | S_TKc | 34-250 | 15 | 6e-09 | -45.66 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 34-250
Range on HMM: 1-231/231
Sequence Identity: 15% (42 aa)
FTRLGSIGRVDFGGVWKGELRSKQSQVDVDIRQIPDQVTKSKNVSEAVKVLSELPDHPNVVKCMGYCQ-EQGSILYEFISG--GTLLTHLQTTGVQSQPT
.. | ||. || |.|. .. .. | | .|. ... ...|.. .|||.||. ...| . . |...| |.|..... | .
YEILRKIGKGAFGKVYKCRHKK--TGRIVAIKIIK------EHIRREIQILKK--HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRH----
YGNLKPERVRIDEGSLLNLAWQIAKGMQYLASKKK--------------------------------PTRWSSPETMVTGDQST-EGDNWSFG-------
. |....| ...||.....|. |.. . .|| . .. . | ||.|
-----GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDEHIKICDFGLARQLTTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEML
--ARPYPKMTFDTVQKEVANGYQMPRPRHCGQEVYSVMSGCWEKEATRRSNFDQILK------SLEMI
|.| . ... | . .|. . ...|..|. ..| ..|. . . .
CGYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | TK5.AA | Tie | 44-164 | 24 | 3.3e-08 | 20.39 | In-house | 3-134 (267) | Show / Hide |
Range on Protein: 44-164 Range on HMM: 3-134/267 Sequence Identity: 24% (33 aa) DFGGVWKGELRSKQSQVDVDIRQIPDQVTKS--KNVSEAVKVLSELPDHPNVVKCMGYCQEQGSILY---EFISGGTLLTHLQTTGV-QSQPTYGNLKPE || | | .. ...| |... . . . . |. . |||.. .| |...| .|| |. | || | | . | . . NFGQVMKAMIKKDGLKMEVAIKMMKEYASEDDHRDFMGELEVMCKVGHHPNIINLVGACEHRG-YLYVAIEYAPYGNLLDFLRKSRVIETDPAFAREHTT RVRIDEGS------LLNLAWQIAKGMQYLASKK |.... | .|. | .|.|||||. |. RFKVNVASTLSSQQILHFAADVARGMQYLSQKQ |
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| Kinase | TK5.AA | UTK | 34-164 | 20 | 6.2e-08 | 23.23 | In-house | 1-138 (296) | Show / Hide |
Range on Protein: 34-164 Range on HMM: 1-138/296 Sequence Identity: 20% (30 aa) FTRLGSIGRVDFGGVWKGELRSKQSQVDVDIRQIPDQVTKSKNVSEAV---KVLSEL--------PD-HPNVVKCMGYCQEQGS--ILYEFISGGTLLTH .. .|. || | |.... .. .... ... ..... | ... | .. ||||.. |.| .. |..|. ..| |.. VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY LQ----TTGVQSQPTYGNLKPERVRIDEGSLLNLAWQIAKGMQYLASKK |. |.. .... .. ..| ||.|| |||||.|.. LRRHRPTPP-----------ACPHWLTLHQRLCMAWDIARGMQYLHSCG |
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| Kinase | TK5.AA | Pkinase | 34-160 | 18 | 2e-07 | 27.31 | Pfam | 1-124 (293) | Show / Hide |
Range on Protein: 34-160
Range on HMM: 1-124/293
Sequence Identity: 18% (26 aa)
FTRLGSIGRVDFGGVWKGELRSKQSQVDVDIRQIPDQVTKSKNVSEA-----VKVLSELPDHPNVVKCMGYCQEQGSIL--YEFISGG----TLLTHLQT
..... ||. || |.|. .. . | . .|. . .||. .. .... .| .|||.|.. ..... ..| |. || | ....|
YHIGRKIGSGSFGCVYKCHHKGTGK--IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST
TGVQSQPTYGNLKPERVRI--DEGSLLNLAWQIAKGMQYL
.. .. .| . . ..||..|..|.
-------------WRHGCFYFSEWECKFYMYQILRGLEYC
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| Kinase | TK5.AA | TKL | 175-247 | 17 | 2e-06 | 18.82 | In-house | 282-364 (364) | Show / Hide |
Range on Protein: 175-247 Range on HMM: 282-364/364 Sequence Identity: 17% (17 aa) MVTGDQSTEGDNWSFGARPYPKMTFDTVQ---------KEVAN-GYQMPRP------------RHCGQEVYSVMSGCWEKEATRRSNFDQILKSL ..|. . || .. ..... . |.. |.. |.| .| ... . | ||. ... | .|..||| | ILTRCR------------PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL |
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| Kinase | TK5.AA | Src | 34-164 | 21 | 1.2e-05 | 15.12 | In-house | 1-117 (255) | Show / Hide |
Range on Protein: 34-164 Range on HMM: 1-117/255 Sequence Identity: 21% (28 aa) FTRLGSIGRVDFGGVWKGELRSKQSQVDVDIRQIPDQVTKSKNVSEAVKVLSELPDHPNVVKCMGYCQEQ--GSILYEFISGGTLLTHLQTTGVQSQPTY .... .|. || ||.| . ...| . . . . . ... .| .|...|. | . | |. | | ||. |. IKLCRKLGQGQFGEVWMGYWNG---NTKVAVKTLKPGTMSPEAFLQEAQIMKKL-RHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKK--------- GNLKPERVRIDEGSLLNLAWQIAKGMQYLASKK ..| .. |. .|.|.|.||.|| |.. ---DGEGRHLHLPQLIDMAAQVAEGMAYLESMN |
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| Kinase | TK5.AA | MLK | 226-247 | 36 | 1.9e-05 | 15.01 | In-house | 270-291 (291) | Show / Hide |
Range on Protein: 226-247 Range on HMM: 270-291/291 Sequence Identity: 36% (8 aa) MSGCWEKEATRRSNFDQILKSL |. ||. .. .| .|.||.. | MKQCWNQDPHKRPSFRQIVQHL |
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| Kinase | TK5.AA | Csk | 34-164 | 27 | 0.000221 | 10.91 | In-house | 1-117 (251) | Show / Hide |
Range on Protein: 34-164
Range on HMM: 1-117/251
Sequence Identity: 27% (37 aa)
FTRLGSIGRVDFGGVWKGELRSKQSQVDVDIRQIPDQ--VTKSKNVSEAVKVLSELPDHPNVVKCMGYCQEQG---SILYEFISGGTLLTHLQTTGVQSQ
. . .|| || | ||.. . | . .| . .. . . || .| .| ||| |. .| .|. .| |..| | |. | . |
LHLGECIGHGEFGDVMQGEYQNRK----VAVKCIKCDGNGMAQAFLAEA-SVMTQL-RHPNLVQLIGVILHQKNHLYIVMEYMSKGNLVDYLRSRG----
PTYGNLKPERVRIDEGSLLNLAWQIAKGMQYLASKK
| | || | ...|| || .||
---------RHVITRRQLLKFAMDVCEGMCYLEQKK
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| Kinase | TK5.AA | Fer | 89-124 | 42 | 0.00023 | 10.9 | In-house | 67-104 (283) | Show / Hide |
Range on Protein: 89-124 Range on HMM: 67-104/283 Sequence Identity: 42% (16 aa) DHPNVVKCMGYCQEQGS--ILYEFISGGTLLTHLQTTG |||||||. |.|. . |. ||..|| |...|.... DHPNVVKFYGVCVDEQPIMIVMEFCNGGSLDSYLKKNK |
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| Kinase | TK5.AA | Pkinase | 220-247 | 23 | 0.050343 | 8.24 | Pfam | 264-293 (293) | Show / Hide |
Range on Protein: 220-247 Range on HMM: 264-293/293 Sequence Identity: 23% (7 aa) QEVYSVMSGCWEKEATRRSNFDQILKS--L .| .....|..| ..| ...|||.. . EECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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