Gene FGFR (Sea Urchin)

FGFR

Species: Sea Urchin
Alias: SPU_020677, FGFR, Spk268
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: TK
Family: FGFR

Sequence

Name Sequence Type Origin Length Description Download
FGFR.AA Protein None 905 None Fasta, JSON
FGFR.kin_dom Protein Kinase Domain None 274 None Fasta, JSON

Protein domain

Protein domains of FGFR.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
I-set FGFR.AA I-set 102-167 30 6.6e-10 36.14 Pfam 15-83 (92) Show / Hide 
Range on Protein: 102-167
Range on HMM: 15-83/92
Sequence Identity: 30% (21 aa)

GFEHKIPCPVKADPRPYTRWLKNGTDLTPNDPDDNVSFTK---TSIVFKRLRFSDAGLYTCVASNFFGQ
|   .  | |. || |   |.|.| .|.|..   ......   ..  ...   .|.| |||||.| ||.
GETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGE
IG FGFR.AA IG 94-178 16 2.4e-09 38.28 SMART 1-58 (58) Show / Hide 
Range on Protein: 94-178
Range on HMM: 1-58/58
Sequence Identity: 16% (15 aa)

KGLVEKSLGFEHKIPCPVKADPRPYTRWLKNGTDLTPNDPDDNVSFTKTSIVFKRLRFSDA---GLYTCVASNFFGQPIH-VNFTLIVV
 . |. ..|   ...| |.     . .|.                     ... .....|.   | |.|.|.   ||     ..||.| 
PP-VTVKEGETVTLTC-VS-----QIWWY---------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
IGc2 FGFR.AA IGc2 100-166 26 3.5e-07 31.09 SMART 1-56 (56) Show / Hide 
Range on Protein: 100-166
Range on HMM: 1-56/56
Sequence Identity: 26% (18 aa)

SLGFEHKIPCPVKADPRPYTRWLKNGTDLTPNDPDDNVSFTKTSIVFKRLRFSDAGLYTCVASNFFG
  |    ..||. ..| |  .|.| |. |           .. .  .|. ...|.|.|||.|.|  |
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP----------WNWTLTIKNVTPEDSGYYTCYARNPWG
V-set FGFR.AA V-set 136-178 27 0.006567 11.86 Pfam 87-128 (128) Show / Hide 
Range on Protein: 136-178
Range on HMM: 87-128/128
Sequence Identity: 27% (12 aa)

NVSFTKTSIVFKRLRFSDAGLYTCVASNFFGQPIHVNFTLIVV
| | .. |.  . |. || | |.|...|. .  .  . |  .|
NPSKNDFSLTISNLQPSDSGTYYCAVWNC-NEDYFGHGTRLTV
I-set FGFR.AA I-set 235-308 30 7.4e-14 49.53 Pfam 18-92 (92) Show / Hide 
Range on Protein: 235-308
Range on HMM: 18-92/92
Sequence Identity: 30% (25 aa)

VRLECGARGTPTPNITWIKDGVQKWKINVIRP----TRVEEKG---FVLIIRRAIVRDTGKYTCIVSNQYGTIEHTYDVKI
.|.|| ..|.|.| ..| ||| .      .||     .. ..|     |.|...  .|.|||||...| .|. | |  ...
ARFECQVTGDPPPQVSWFKDGQP------LRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV
IGc2 FGFR.AA IGc2 230-298 28 3.7e-10 41.01 SMART 1-56 (56) Show / Hide 
Range on Protein: 230-298
Range on HMM: 1-56/56
Sequence Identity: 28% (20 aa)

PSNTKVRLECGARGTPTPNITWIKDGVQKWKINVIRPTRVEEKGFVLIIRRAIVRDTGKYTCIVSNQYG
 . . |.|.|.|.| |.|||.|.|      ...         ..  | |... . | |.|||...|  |
HEGQSVTLTCPATGNPDPNIHWYK----GQPLP---------WNWTLTIKNVTPEDSGYYTCYARNPWG
IG FGFR.AA IG 224-309 14 7.2e-09 36.71 SMART 1-58 (58) Show / Hide 
Range on Protein: 224-309
Range on HMM: 1-58/58
Sequence Identity: 14% (13 aa)

EPEKPLPSNTKVRLECGARGTPTPNITWIKDGVQKWKINVIRPTRVEEKGFVLIIRRAIVRDT---GKYTCIVSNQYGTIEH--TYDVKIR
 |         |.|.| .      .|.|                        |.| .. . |.   | |.| ..  .|...   .  ....
PP-VTVKEGETVTLTC-VS-----QIWWY-----------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
V-set FGFR.AA V-set 274-308 27 1.248675 4.0 Pfam 93-128 (128) Show / Hide 
Range on Protein: 274-308
Range on HMM: 93-128/128
Sequence Identity: 27% (10 aa)

FVLIIRRAIVRDTGKYTCIVSNQ-YGTIEHTYDVKI
| | |. . . |.| |.| |.|  ... .| . . .
FSLTISNLQPSDSGTYYCAVWNCNEDYFGHGTRLTV
IG FGFR.AA IG 321-452 15 5.5e-10 40.42 SMART 1-58 (58) Show / Hide 
Range on Protein: 321-452
Range on HMM: 1-58/58
Sequence Identity: 15% (21 aa)

MKNVTATVGSNTSFVCRVVSDLTPHFAWMRFNGTNNTKQRLTDIDDHISILQQRWVEEPMLTCDEFLDVFYQNQSKRMLECLHLIQLETQGGMEEANQLK
 . ||. .|.. .. | |      .. |.                                                                     | 
PP-VTVKEGETVTLTC-VS-----QIWWY---------------------------------------------------------------------LT

LYNVQYEDE---GPYLCVAGNFYGMSWE--GAYLDVV
. |||.||.   | | |.|   .|. |   |..| | 
I-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
IGc2 FGFR.AA IGc2 327-441 13 0.004463 4.4 SMART 1-56 (56) Show / Hide 
Range on Protein: 327-441
Range on HMM: 1-56/56
Sequence Identity: 13% (16 aa)

TVGSNTSFVCRVVSDLTPHFAWMRFNGTNNTKQRLTDIDDHISILQQRWVEEPMLTCDEFLDVFYQNQSKRMLECLHLIQLETQGGMEEANQLKLYNVQY
  | . .. |..  . .| . | .  |.                                                              . |.. ||..
HEGQSVTLTCPATGNPDPNIHWYK--GQPLP---------------------------------------------------------WNWTLTIKNVTP

EDEGPYLCVAGNFYG
||.| | |.| |  |
EDSGYYTCYARNPWG
I-set FGFR.AA I-set 419-451 48 0.015272 11.14 Pfam 60-92 (92) Show / Hide 
Range on Protein: 419-451
Range on HMM: 60-92/92
Sequence Identity: 48% (16 aa)

LKLYNVQYEDEGPYLCVAGNFYGMSWEGAYLDV
|  .||| .||| | ||| | .| ..  | | |
LTISNVQPDDEGKYTCVATNSFGEAECTAELTV
V-set FGFR.AA V-set 418-452 25 0.882423 4.52 Pfam 94-128 (128) Show / Hide 
Range on Protein: 418-452
Range on HMM: 94-128/128
Sequence Identity: 25% (9 aa)

QLKLYNVQYEDEGPYLCVAGNFYGMSWEGAYLDVV
.|.. |.| .|.| | |.. |.. ..... .  .|
SLTISNLQPSDSGTYYCAVWNCNEDYFGHGTRLTV
Kinase FGFR.AA FGFR 572-845 65 1.5e-225 755.63 In-house 1-293 (293) Show / Hide 
Range on Protein: 572-845
Range on HMM: 1-293/293
Sequence Identity: 65% (192 aa)

LTVGKTIGEGAFGKVVIGEAVGIVCQ--EKTSTVAVKMLKANAMDREFSDLISELAMMKMIGKNPNIINLLGCCTQEGPPYVIVEFAHHGNLRDFLRSRR
||.||..|||.||.|...||.||.|.  ||..||||||||.|..|...|||.||..|||||||..||||||||||||||.|||||..||||||||||.||
LTLGKMLGEGCFGQVWMAEAKGIDCDRPEKEITVAVKMLKMNHTDKDLSDLVSEMEMMKMIGKHKNIINLLGCCTQEGPLYVIVEYCHHGNLRDFLRARR

PPE-EYEKSIL-------LTTSQT--------LTNKDLMSMAYQVARGMDFLASKKCIHRDLAARNVLVTEDFEMKICDFGLARDIHYIDFYRKTTDGRL
||. .|.|..        ....|.        ||.|||.|.||||||||..|||.|||||||||||||||.|..|||||||||||||.||.|||||.|||
PPGMDYKKDSQEYTDYKPRKPEQQDDIELIPNLTQKDLVSCAYQVARGMEYLASRKCIHRDLAARNVLVTDDYVMKICDFGLARDIHCIDYYRKTTNGRL

PVKWMAPEALFDRMFTTQSDVWSFGILLWEIMTLGGTPYPSVP-VEQMFDYLRSGKRLEKPQNTSLEIYHILCECWRTSPGQRPTFCELVEDL
|.|||||||||||..|.||||||.|.|||||||.||.|||..| ||....||..|.|.|||.|.|.||||..|.||...|.|||||..|||.|
PIKWMAPEALFDRVYTHQSDVWSYGVLLWEIMTYGGQPYPHIPSVEELYKYLKEGHRMEKPHNCSQEIYHMMCQCWHFKPCQRPTFKQLVEYL
Kinase FGFR.AA Pkinase_Tyr 572-845 47 1.1e-149 507.56 Pfam 1-270 (270) Show / Hide 
Range on Protein: 572-845
Range on HMM: 1-270/270
Sequence Identity: 47% (134 aa)

LTVGKTIGEGAFGKVVIGEAVGIVCQEKTSTVAVKMLKANAMDRE--FSDLISELAMMKMIGKNPNIINLLGCCT-QEGP--PYVIVEFAHHGNLRDFLR
.| ||..||||||.|. |.. |   .... .||||||| .||...    |...|...|| .|..|||..|.|.|| |..|  .|...|.. ||.|.|.||
ITFGKKLGEGAFGEVYKGTWKG-DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

SRRPPEEYEKSILLTTSQTLTNKDLMSMAYQVARGMDFLASKKCIHRDLAARNVLVTEDFEMKICDFGLARDIHYIDFY-RKTTDGRLPVKWMAPEALFD
..|           .  | || ||| .|..|.|.||..|.||.||||||||||.||||.. .|||||||||||.  | | ||...|.||.||||||....
KHR-----------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINY

RMFTTQSDVWSFGILLWEIMTLGGTP-YPSVPVEQMFDYL-RSGKRLEKPQNTSLEIYHILCECWRTSPGQRPTFCELVEDL
. |||.|||||||.|.|||.|.|..| || .. |....|. ..| |...|.|.. |||.....||.  | .|||| |..|.|
GKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase FGFR.AA TyrKc 572-845 39 2.6e-138 466.72 SMART 1-280 (280) Show / Hide 
Range on Protein: 572-845
Range on HMM: 1-280/280
Sequence Identity: 39% (122 aa)

LTVGKTIGEGAFGKVVIGEAVGIVCQEKTSTVAVKMLKANAMDREFSDLISELAMMKMIG-KNPNIINLLGCCTQE-------GPPYVIVEFAHHGNLRD
.| ||..||||||.|. |..          .|||||||..|      |...|. .|...| ..|||..|.|.|||.       .|.....|.. ||.|.|
ITLGKKLGEGAFGEVYKGTWK--------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

FLRSRRPPEEYEKSILLTTSQTLTNKDLMSMAYQVARGMDFLASKKCIHRDLAARNVLVTEDFEMKICDFGLARDIHYI-------DFYRKTT--DGR--
.||..||               |..||| |...|.|.||..|.||.||||||||||.||.|.. .||.||||.|||.         | |||..  .|.  
YLRKHRPK--------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTM

LPVKWMAPEALFDRMFTTQSDVWSFGILLWEIMTLGGTPYPS-----VPVEQMFDYLRSGKRLEKPQN--------TSLEIYHILCECWRTSPGQRPTFC
||..|||||......|||.|||||||...|||.|.|..|||      .. .... |...|.|...|.|         . |.| |  .||.  | .|||| 
LPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFS

ELVEDL
|..|..
EIHECF
Kinase FGFR.AA TK 572-845 26 8.49999999999e-126 423.98 In-house 1-486 (486) Show / Hide 
Range on Protein: 572-845
Range on HMM: 1-486/486
Sequence Identity: 26% (129 aa)

LTVGKTIGEGAFG---KVVIGEAVGIVC--------------------QEKTSTVAVKMLK--ANAMDREFSD--------------LISELAMMKM-IG
.|.||..|||.||   .|  ||. |.                       ... .|||||||  ... ..|| |              . .|..||.. .|
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

KNPNIINLLGCCTQE------------GPPYVIVEFAHHGN----LRDFLRSRRPPEEYEKSILL-----------------------------------
. |||..|.|.|||.            .|.....|...||.    |||.||..||..  | .                                      
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

------TTSQTLTNKDLMS-------------------MAYQVARGMDFLASKKC------IHRDLAARNVLVTEDFE-----------MKICDFG----
      . ...|| ||| .                   |..|.|.|| .|.||.|      .||||||||.||.|.              ||.|||    
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQ

----LARDIHYIDFYRKTT------------------------DGRLPVKWMAPEALFDRM---------FTTQSDVWSFGILLWEIMTLG-GTPYPSVP
    |||||.. | |....                        .|.||..|||||.|.||          |||.|||||||.|.|||.|.| ...|. ..
GSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMS

V---------EQMFDYLRSG--------------KRLEKPQNTS--------------LEIYHILCECWRTSPGQRPTFCELVEDL
          .....|||.|               |...|.. .               |.| ....||.  | .|||| .|.| |
NQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase FGFR.AA TK-Unique 572-845 44 5.8e-118 398.19 In-house 1-294 (294) Show / Hide 
Range on Protein: 572-845
Range on HMM: 1-294/294
Sequence Identity: 44% (131 aa)

LTVGKTIGEGAFGKVVIGEAVGIV-CQEKTSTVAVKMLKANAMDREFSDLISELAMMKMIGKNPNIINLLGCCTQEG-PPYVIVEFAHHGNLRDFLRSRR
|.||..||||||| |  ||..||   ..|.. |||||||.|| | . .|. .|..||| .|. |||...|||||  . |.. | |... |||...||..|
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

PP--EEYEKSILLT--------TSQT--LTNKDLMSMAYQVARGMDFLAS--KKCIHRDLAARNVLVTEDFEMKICDFGLARDIHYIDFYRKT-TDGRLP
|.  . . .   |         . .|  .. ||| . |.|.|.|| .|||  ||..||||.|||||.|||.. ||||||.|||..    | .. . ||.|
PAMRQHQ-TYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIP

VKWMAPEALF--DRMF-TTQSDVWSFGILLWEIMTLGGTPYPSVPVEQMFDYLRSGKRLEKPQNT-SLEIYHILCECWRTSPGQRPTFCELVEDL
..|||||.|   ..|. ||.|||||||.|.|||.|||..|||..| ... . .| |.|...|..  | |.| .. .||. .| .||.| ...  |
IRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase FGFR.AA Ret 572-847 41 8.70000000001e-106 357.74 In-house 1-293 (293) Show / Hide 
Range on Protein: 572-847
Range on HMM: 1-293/293
Sequence Identity: 41% (123 aa)

LTVGKTIGEGAFGKVVIGEAVGIVCQEKTSTVAVKMLKAN-AMDREFSDLISELAMMKMIGKNPNIINLLGCCTQEG--PPYVIVEFAHHGNLRDFLRSR
|  ..| ||| ||.|| . |  |       |||||||| | |   |. || ||. . | .   |..| |.| |.|..  |. .|||..  | || |||  
LQLDDTLGEGHFGQVVKAQAFHIRGHPGYTTVAVKMLKRNTANSSEYHDLLSEFQLLKQVNH-PHVIKLYGACIQDDPFPTCLIVEYCKYGCLREFLRLS

RPP--------EEYEKSILLTTS--QTLT-----NKDLMSMAYQVARGMDFLASKKCIHRDLAARNVLVTEDFEMKICDFGLARDIHYIDFYRKTTDGRL
|             . ||.        ..      |...| | |. .|| .|.. | .||||||||||| |   .|| |||| ||.   | | |   .|.
RKIGPYYEYSIGNRNCSIVDHPDGKDVINRFDIGMKMIISFAWQICKGMHYLSEMKLVHRDLAARNVLVAEGRICKISDFGLTRDVYEDDSYVKRSKDRI

PVKWMAPEALFDRMFTTQSDVWSFGILLWEIMTLGGTPYPSVPVEQMFDYLRSGKRLEKPQNTSLEIYHILCECWRTSPGQRPTFCELVEDLDR
||||||.|.|.|  .||.|||||||.|.||| |.|. ||| .| |  .  |. | | . | | | |.| |.  ||.  |  || |  .  |. .
PVKWMAIESLYDHVYTTKSDVWSFGVLCWEIVTMGANPYPGIPPERLWQLLKTGYRMDRPENCSEEMYRIMRQCWKQEPDKRPVFKFISKDFEK
Kinase FGFR.AA RTKB 572-845 41 2.1e-98 332.33 In-house 1-264 (264) Show / Hide 
Range on Protein: 572-845
Range on HMM: 1-264/264
Sequence Identity: 41% (114 aa)

LTVGKTIGEGAFGKVVIGEAVGIVCQEKTSTVAVKMLKANAMDREFSDLISELAMMKMIGKNPNIINLLGCCTQEGPPYVIVEFAHHGNLRDFLRSRRPP
.  |.  |.|||| |  .  |    . ..  .|.| ||. |  .|  |  ||...|| .|  ||.| ..| | |. |. . ||.. .|||||.|| .| .
VWLGEKLGNGAFGEVFQA-WVRNRHMNTEQSCAAKVLKPGASYEERQDFCSEMTVMKELGWHPNVIGIIGHCLQDEPYILLVELCELGNLRDYLRMCRAS

EEYEKSILLTTSQTLTNKDLMSMAYQVARGMDFLASKKCIHRDLAARNVLVTEDFEMKICDFGLARDIHYIDFYRKTTDGRLPVKWMAPEALFDRMFTTQ
..         .|.|  . |.. . |.|.|| || ... |||||.||||||. ... ||||||.|| |   ..|..|.. |||.|||||| . .| .||.
QH--------NPQSLKQAQLVDFCHQIACGMAFLHQHNVIHRDLCARNVLVDQQLHCKICDFGMAREIDH-ECYETTCT-RLPIKWMAPESWAHRIYTTK

S-DVWSFGILLWEIMTLGGTPYPSVPVEQMFDYLRSGKRLEKPQNTSLEIYHILCECWRTSPGQRPTFCELVEDL
| ||||||.  ||| .||||||.  .. ..|..|.|| ||.||.  . ...||.  ||   . .||.| |||. .
SGDVWSFGVTMWEIFSLGGTPYQQYRNGDIFYWLESGHRLPKPRQMPQAADHIMQMCWQMEAQHRPDFDELVDAF
Kinase FGFR.AA InsR 572-847 40 5.4e-96 322.93 In-house 1-278 (278) Show / Hide 
Range on Protein: 572-847
Range on HMM: 1-278/278
Sequence Identity: 40% (112 aa)

LTVGKTIGEGAFGKVVIGEAVGIVCQEKTS--TVAVKMLKANAMDREFSDLISELAMMKMIGKNPNIINLLGCCTQEGPPYVIVEFAHHGNLRDFLRSRR
.. ..  |.|.||.|  | | |||  |.     .|.| ...|| .||  .  .|   || . .  ....||| |..  | ||. |.  .|.|...|||||
IVLIRECGQGSFGMVYEGIAKGIVPDEEWRFGRCAIKTVNENASMRERIEFLNEASVMKEF-NCHHVVRLLGVCSRGQPMYVVMEMMTYGDLKSYLRSRR

PPEEYEKSILLTTSQTLTNKDLMSMAYQVARGMDFLASKKCIHRDLAARNVLVTEDFEMKICDFGLARDIHYIDFYRKTTDGRLPVKWMAPEALFDRMFT
| ||     .    .  .  ....|| ... || .||.|| .|||||.|| .| .||  || |||..||| . | ||| . | ||| ||||| | |  ||
PEEEFNNPGCNRNQHVPCLDQMHQMAAEICDGMAYLAAKKFVHRDLACRNCMVNHDFTVKIGDFGMTRDIYEHDYYRKGGKGMLPVRWMAPESLKDGVFT

TQSDVWSFGILLWEIMTLGGTPYPSVPVEQMFDYL-RSGKRLEKPQNTSLEIYHILCECWRTSPGQRPTFCELVEDLDR
|.|||||||..|||. |||  ||     ||  .|  . |. |..| | .   . .   ||. .|  |||| .... |  
THSDVWSFGVVLWEMVTLGEQPYQGLSNEQVLKYIGMDGNVLRPPENCPEYWQELMMMCWQYQPKMRPTFLDIIHYLCD
Kinase FGFR.AA UTK 572-845 33 1.2e-93 317.44 In-house 1-296 (296) Show / Hide 
Range on Protein: 572-845
Range on HMM: 1-296/296
Sequence Identity: 33% (100 aa)

LTVGKTIGEGAFGKVVIGEAVGIVCQEKTSTVAVKMLKANAMDREFSD----LISELA---MMKMIGKNPNIINLLGCCTQEGPPYVIVEFAHHGNLRDF
.  |...|.|||| |  .... .  ..... |||| ... |... ...    .. | .   |||.    ||...|.| ||||.|.....|..  |.||..
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LRSRRPPEEYEKSILLTTSQTLTNKDLMSMAYQVARGMDFLASKKCIHRDLAARNVLVTED-------FEMKICDFG---LARDIH---------YIDFY
||. ||  .            ||. ....||...|||| .|.|....||||||||.||...          ||.|||   ..|...         . . |
LRRHRPTPP-------ACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYY

RKTTDGRLPVKWMAPEALFDR-MFTTQSDVWSFGILLWEIMTLGGTPYPSVPVEQMFDYLRSG--KRLEKPQNTSLEIYHILCECWRTSPGQRPTFCELV
... ..|.|..||||||| ..  |||.|||||||...|||.| | .|||    .| .  .. |   |...|.  ....| .. .||...|  ||.| .||
MAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLV

EDL
. .
QQM
Kinase FGFR.AA VEGFR 684-845 55 1.5e-91 310.41 In-house 168-332 (332) Show / Hide 
Range on Protein: 684-845
Range on HMM: 168-332/332
Sequence Identity: 55% (91 aa)

QTLTNKDLMSMAYQVARGMDFLASKKCIHRDLAARNVLVTEDFEMKICDFGLARD-IHYIDFYRKTTD-GRLPVKWMAPEALFDRMFTTQSDVWSFGILL
. ||..|| . ..||||||.||||.|||||||||||.|..|.   |||||||||. |   . | . .| |||| ||||||..||. .||.|||||.|..|
DPLTMEDLICYSFQVARGMEFLASRKCIHRDLAARNILLCENNVVKICDFGLARHGIYKDPDYVRKGDQGRLPIKWMAPESIFDKVYTTYSDVWSYGVFL

WEIMTLGGTPYPSVP-VEQMFDYLRSGKRLEKPQNTSLEIYHILCECWRTSPGQRPTFCELVEDL
||| .||| ||| |   |  .  |..| |...|  .  |||||  .||.. | .||.| |||| |
WEIFSLGGSPYPGVQIDEEFCNRLKDGYRMRAPDYCTPEIYHIMLDCWHKEPEERPHFSELVEHL
Kinase FGFR.AA Src 572-845 38 5.5e-85 288.65 In-house 1-255 (255) Show / Hide 
Range on Protein: 572-845
Range on HMM: 1-255/255
Sequence Identity: 38% (107 aa)

LTVGKTIGEGAFGKVVIGEAVGIVCQEKTSTVAVKMLKANAMDREFSDLISELAMMKMIGKNPNIINLLGCCTQEGPPYVIVEFAHHGNLRDFLRSRRPP
..  . .|.| || |  |   | .       |||| ||.  |. |  ..  |   ||   . .....|.  |.|| | | . |.  ||.| |.|.     
IKLCRKLGQGQFGEVWMGYWNGNT------KVAVKTLKPGTMSPE--AFLQEAQIMKKL-RHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKK----

EEYEKSILLTTSQTLTNKDLMSMAYQVARGMDFLASKKCIHRDLAARNVLVTEDFEMKICDFGLARDIHYI-DFYRKTTDGRLPVKWMAPEALFDRMFTT
         .. ..|  ..| .|| |||.||..| |.. |||||||||||| |.   |..|||||| |    | |   .. ..|.||.||||.  . ||.
--------DGEGRHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTI

QSDVWSFGILLWEIMTLGGTPYPSVPVEQMFDYLRSGKRLEKPQNTSLEIYH-ILCECWRTSPGQRPTFCELVEDL
 ||||||||||.||.| | .|||    .. .. .  | |. .|.|   |.|. |...||. .| |||||  | . |
KSDVWSFGILLTEIVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase FGFR.AA PDGFR 683-845 55 1.9e-82 264.43 In-house 195-358 (358) Show / Hide 
Range on Protein: 683-845
Range on HMM: 195-358/358
Sequence Identity: 55% (91 aa)

SQTLTNKDLMSMAYQVARGMDFLASKKCIHRDLAARNVLVTEDFEMKICDFGLARDIHYIDFYRKTTDGRLPVKWMAPEALFDRMFTTQSDVWSFGILLW
|. || .||.. .||||.||.||||| |.||||||||||...    |||||||||||     |      |||||||||| .||  .||||||||.|||||
SNVLTYWDLLCFSYQVAKGMEFLASKNCVHRDLAARNVLLCHGKVVKICDFGLARDIMNDSNYVVKGNARLPVKWMAPESIFDCVYTTQSDVWSYGILLW

EIMTLGGTPYPSVPVEQMF-DYLRSGKRLEKPQNTSLEIYHILCECWRTSPGQRPTFCELVEDL
|| .|||.||| .||.. |    ..| | ..|.  . ||| |  .||   | .|||| .|.. |
EIFSLGGNPYPGMPVDSKFYKMIKEGYRMAQPFHAPEEIYEIMQKCWDFDPEKRPTFQQLCQFL
Kinase FGFR.AA S_TKc 572-849 24 2.2e-49 171.31 SMART 1-231 (231) Show / Hide 
Range on Protein: 572-849
Range on HMM: 1-231/231
Sequence Identity: 24% (69 aa)

LTVGKTIGEGAFGKVVIGEAVGIVCQEKTSTVAVKMLKANAMDREFSDLISELAMMKMIGKNPNIINLLGCCTQEGPPYVIVEFAHH--GNLRDFLRSRR
 .....||.||||||  .  ..         ||.|..|         ....|....|.  . |||..|....   .  |.. |.. .  |.|.|....|.
YEILRKIGKGAFGKVYKCRHKK-----TGRIVAIKIIK--------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRG

PPEEYEKSILLTTSQTLTNKDLMSMAYQVARGMDFLASKKCIHRDLAARNVLVTEDFEMKICDFGLARDIHYIDFYRKTTDGRLPVKWMAPEALFDRMFT
..  .         . ..  .  ...||........ |.. |||||   |.|..|  . ||||||||| .         |       .|||| |    ..
RHGLR---------FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYG

T-QSDVWSFGILLWEIMTLGGTPYPSVPVEQMFDYLRSGKRLEKPQNTSLEIYHILCECWRTSPGQRPTFCELVE-----DLDRII
.  .|.||.|..|.| .. | .|.|   ...||. ..           | |  .... |..  | .|||  |. .      ..  .
KCKCDWWSCGCILYEMLC-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase FGFR.AA Pkinase 572-845 21 2.5e-44 157.79 Pfam 1-293 (293) Show / Hide 
Range on Protein: 572-845
Range on HMM: 1-293/293
Sequence Identity: 21% (68 aa)

LTVGKTIGEGAFGKVVIGEAVGIVCQEKTSTVAVKMLKANAMDREFSDLI---SELAMMKMIGKNPNIINLLGCCTQEGPPYVIVEFAHHG----NLRDF
...|..||.|.||.| ..  .|  .     .|||| .|    . ..       ||...||.. . |||. |..... .. .|.. |.. .|     | |.
YHIGRKIGSGSFGCVYKCHHKGTGK-----IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDY

LRSRRPPEEYEKSILLTTSQTL--TNKDLMSMAYQVARGMDFLASKKCIHRDLAARNVLVTEDFEM----KICDFGLARDIHYIDFYRKTTDGRLPVKWM
..                . ..  . ... ...||..||.... |...|||||   |.|. .. .     ||||||||. .  .  .. .|.      .|
IST-------------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYM

APEALF-DRMFTTQSDVWSFGILLWEIMTLGGTPYPSV------PVEQMFDYLRSGKRLEKPQNTS--------------------LEIYHILCECWRTS
||| .  ... .. .|.||.|..|.| .. | .|.|.          ||..  ....  .  ....                     |  .... |..  
APEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKD

PGQRPTFCELVED--L
| .|||. .....  .
PKKRPTAEQILQHPWF
Kinase FGFR.AA VEGFR 572-669 49 1.3e-40 141.29 In-house 1-101 (332) Show / Hide 
Range on Protein: 572-669
Range on HMM: 1-101/332
Sequence Identity: 49% (50 aa)

LTVGKTIGEGAFGKVVIGEAVGIVCQEKTSTVAVKMLKANAMDREFSDLISELAMMKMIGKNPNIINLLGCCT---QEGPPYVIVEFAHHGNLRDFLRSR
|  || .|.||||.|. ..|.||   | . ||||||||..|   |   | ||| |.. ||.  |  |.|||||   | ||  ||||.  .||| ..||. 
LKLGKMLGRGAFGQVHEASAFGIRKMETCTTVAVKMLKEGATASEHRALMSELKMLIHIGHHLNVVNFLGCCTKNIQKGPLMVIVEYCCFGNLSNYLRTK

R
|
R
Kinase FGFR.AA PDGFR 572-669 46 1.9e-32 101.23 In-house 1-98 (358) Show / Hide 
Range on Protein: 572-669
Range on HMM: 1-98/358
Sequence Identity: 46% (46 aa)

LTVGKTIGEGAFGKVVIGEAVGIVCQEKTSTVAVKMLKANAMDREFSDLISELAMMKMIGKNPNIINLLGCCTQEGPPYVIVEFAHHGNLRDFLRSRR
|  ||| | ||||||| . | |.   . . .|||||||  |   |   | ||| .|   |.  ||.|||| ||  || |.| |.   | | ..|...|
LQFGKTLGSGAFGKVVEATAYGLSKSQAVMKVAVKMLKPTAHSSEKEALMSELKIMSHLGQHMNIVNLLGACTHGGPIYIITEYCCYGDLLNYLHRKR