Gene Abl (Sea Urchin)

Abl

Species: Sea Urchin
Alias: Spk253, Abl, SPU_023952
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: TK
Family: Abl

Sequence

Name Sequence Type Origin Length Description Download
Abl.AA Protein None 1016 None Fasta, JSON
Abl.kin_dom Protein Kinase Domain None 252 None Fasta, JSON

Protein domain

Protein domains of Abl.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
SH3 Abl.AA SH3 75-133 25 2.7e-17 64.72 SMART 1-58 (58) Show / Hide 
Range on Protein: 75-133
Range on HMM: 1-58/58
Sequence Identity: 25% (15 aa)

DLFVVLYDFNGGVENQLTVRKGDHVRILGYNKGGEWCEAKKLKNGKTGWVPVTYVTPFN
  ...|||...  .. |...||| ...|  . ...|..... ..|..||.| .||.. .
PYVRALYDYQAQNPDELSFKKGDIITVLEKD-DDGWWKGRCNRTGQEGWFPSNYVEEID
SH3_1 Abl.AA SH3_1 78-126 26 3.6e-14 50.79 Pfam 1-49 (49) Show / Hide 
Range on Protein: 78-126
Range on HMM: 1-49/49
Sequence Identity: 26% (13 aa)

VVLYDFNGGVENQLTVRKGDHVRILGYNKGGEWCEAKKLKNGKTGWVPV
|.|||...  .. |. .||| . ..  .....|.... . .|..||.|.
VALYDYQAQQPDELSFKKGDIIHVIEKSDDWDWWKGRCNNTGQEGWFPS
SH3_2 Abl.AA SH3_2 76-132 20 1e-08 33.45 Pfam 1-68 (68) Show / Hide 
Range on Protein: 76-132
Range on HMM: 1-68/68
Sequence Identity: 20% (14 aa)

LFVVLYDFNG-GVENQ-----LTVRKGDHVRIL--GYNKGGEWCEA-KKLKNGKT--GWVPVTYVTPF
...|. |...   .|      |...||| ....  |  . ..|...  ....|..  ||.| ..| . 
YYRVHCDYVPATYCNENHEPQLHFKKGDVIKVIDNGDKDWDNWWWCWETIWGGRRMRGWFPSQWVEEC
SH2 Abl.AA SH2 140-215 49 2.6e-41 123.09 Pfam 1-81 (81) Show / Hide 
Range on Protein: 140-215
Range on HMM: 1-81/81
Sequence Identity: 49% (40 aa)

WYHGPISRNAAEYLLSS--GIDGSFLVRDSESSPGHRSISLRFDG---RVYHYRISSGSDGKVFVTTESKFSTIAELVHHH
||||.|||. || || .  . ||.||||.|||.||. ..|.|.||   ||.|||| .  .|....|.. ||....|||.|.
WYHGKISRQEAERLLMNPGNPDGTFLVRESESTPGDYTLSVRDDGPGDRVKHYRIQRTDNGGYYITGRHKFCSLQELVEHY
SH2 Abl.AA SH2 138-221 46 1.4e-34 122.11 SMART 1-87 (87) Show / Hide 
Range on Protein: 138-221
Range on HMM: 1-87/87
Sequence Identity: 46% (41 aa)

HSWYHGPISRNAAEYLLSS--GIDGSFLVRDSESSPGHRSISLRFDGRVYHYRISSGSDGKVFVTT--ESKFSTIAELVHHHCKQSDG
. ||||.|||  || || .  . ||.||||||||.||. ..|.|..|.|.|||| .  |||.....  . ||... |||.|. . ..|
QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWKGKVKHYRIRRNDDGKYYIDETWRRKFPSL-ELVNHYQHNPLG
Kinase Abl.AA Abl 255-506 77 1.1e-198 666.39 In-house 1-252 (252) Show / Hide 
Range on Protein: 255-506
Range on HMM: 1-252/252
Sequence Identity: 77% (196 aa)

ISMKNKLGGGQYGEVYEAIWKKHNKIVAVKTLREENMRVDEFLREAAVMKNVKHPNLVQLLGVCTREPPFYIVTEFMPYGNLLEYLRDNDETSLPAVTLL
|.||.||||||||||||..||.|...||||||.|..|.|.|||.|||.||..||||||||||||||||||||.||||.|||||.|||..|...||||.||
IMMKHKLGGGQYGEVYEGVWKRHDCTVAVKTLKEDTMEVHEFLKEAAIMKEMKHPNLVQLLGVCTREPPFYIITEFMCYGNLLDYLRECDREELPAVVLL

YMATQVAFGMSYLEKNSFIHRDLAARNCLLGEHHLLKVADFGLARMVQGEIYTAQAGAKFPIKWTAPESLAYYKFSSKSDVWAFGILLWEIATYGCSPYP
|||||.|.|||||||..||||||||||||.||||..||||||||||.....|||.|||||||||||||||||.||||||||||||.|||||||||.||||
YMATQIASGMSYLEKRHFIHRDLAARNCLVGEHHIVKVADFGLARMMKDDTYTAHAGAKFPIKWTAPESLAYNKFSSKSDVWAFGVLLWEIATYGMSPYP

GVDLQHVYGKLEQGYRMERPEGCPTDVYKLMHKCWEWRHTDRPSFTEIHEEM
|.||.|||.|||.|||||||||||..||.||..||.|.|||||||.|||..|
GIDLSHVYHKLEKGYRMERPEGCPPKVYELMRQCWQWSHTDRPSFKEIHHAM
Kinase Abl.AA Pkinase_Tyr 255-506 48 6.30000000001e-144 488.08 Pfam 1-270 (270) Show / Hide 
Range on Protein: 255-506
Range on HMM: 1-270/270
Sequence Identity: 48% (132 aa)

ISMKNKLGGGQYGEVYEAIWK----KHNKIVAVKTLREENMRV----DEFLREAAVMKNV-KHPNLVQLLGVCT-REPP--FYIVTEFMPYGNLLEYLRD
|..  ||| |..||||...||    ...  ||||.|.|  |      ..|.|||..||.  .|||.|.|.|||| .. |   |||.|.||.|.||.|||.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

N--DETSLPAVTLLYMATQVAFGMSYLEKNSFIHRDLAARNCLLGEHHLLKVADFGLARMV-QGEIY-TAQAGAKFPIKWTAPESLAYYKFSSKSDVWAF
.  |. .|.  .|| |..|.| ||.||| . .|||||||||||..| .  |..|||||| .   . | ... |.|.||||.|||...|.||..|||||.|
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSF

GILLWEIATYGCSP-YPGVDLQHVYGKL-EQGYRMERPEGCPTDVYKLMHKCWEWRHTDRPSFTEIHEEM
|.|.||| ||| .| |||.. . || .. |.||||..||.|| ..|.|| .||..   |||.|.||||..
GVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase Abl.AA TyrKc 255-506 42 4.90000000001e-139 469.11 SMART 1-280 (280) Show / Hide 
Range on Protein: 255-506
Range on HMM: 1-280/280
Sequence Identity: 42% (122 aa)

ISMKNKLGGGQYGEVYEAIWKKHNKIVAVKTLREENMRVDEFLREAAVMKNV--KHPNLVQLLGVCTRE-------PPFYIVTEFMPYGNLLEYLRDNDE
|... ||| |..||||...||     ||||.|.|.   . .|.||| .|...  .|||.|.|.|||| .       .| .||.|.||.|.|..|||.. .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

TSLPAVTLLYMATQVAFGMSYLEKNSFIHRDLAARNCLLGEHHLLKVADFGLARMVQGE--------IYTAQA--GAK--FPIKWTAPESLAYYKFSSKS
. |.  .||....|.| ||.||... .|||||||||||.|| |  |..||||.| .  .         |...   |.|  .||.|.|||.. |.||..||
K-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKS

DVWAFGILLWEIATYGCSPYPG-----VDLQHVYGKLEQGYRMERPEG--------CPTDVYKLMHKCWEWRHTDRPSFTEIHEEM
|||.||...||| ||| .||||     .. |.|. ...|||||..|.         ||...|..| .||.    |||.|.||||..
DVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase Abl.AA SFK-Src 255-510 50 3.3e-136 406.43 In-house 1-259 (259) Show / Hide 
Range on Protein: 255-510
Range on HMM: 1-259/259
Sequence Identity: 50% (130 aa)

ISMKNKLGGGQYGEVYEAIWKKHNKIVAVKTLREENMRVDEFLREAAVMKNVKHPNLVQLLGVCTREPPFYIVTEFMPYGNLLEYLRDNDETSLPAVTLL
| .. ||| ||.|.|.   | .    ||||||.   |  .|||.||.|||  .||||.||  |||   | ||.|| | || || ||..    ||   .| 
IRLEKKLGSGQFGDVWKGRWNNTTE-VAVKTLKPGAMSAEEFLQEAQVMKKLRHPNLIQLYAVCTDGEPIYIITELMKYGSLLDYLHEPHGRSLRMPQLV

YMATQVAFGMSYLEKNSFIHRDLAARNCLLGEHHLLKVADFGLARMV-QGEI-YTAQAGAKFPIKWTAPESLAYYKFSSKSDVWAFGILLWEIATYGCSP
 || ||| || ||| . |.|||||||| | |.    ||.|||..|.. | .. |||. ||||||||||||   . .|| |||||.||||. || |||  |
DMAAQVAHGMAYLEAQNFVHRDLAARNVLVGDNNVCKVGDFGMSRVLAQDDEGYTAHEGAKFPIKWTAPEAMNMNRFSIKSDVWSFGILMMEIVTYGRIP

YPGVDLQHVYGKLEQ--GYRMERPEGCPTDVYKLMHKCWEWRHTDRPSFTEIHEEMNNMF
|||   . |  ....  ||||. | .||   ||.|  ||  .  ||| |      | . |
YPGMTNMEVLQQVDRPEGYRMPCPPNCPDEYYKIMFDCWQHEPDDRPTFESLKWQMEDFF
Kinase Abl.AA SFK-Abl 255-506 53 2.9e-135 444.03 In-house 1-251 (251) Show / Hide 
Range on Protein: 255-506
Range on HMM: 1-251/251
Sequence Identity: 53% (135 aa)

ISMKNKLGGGQYGEVYEAIWKKHNKIVAVKTLREENMRVDEFLREAAVMKNVKHPNLVQLLGVCTREPPFYIVTEFMPYGNLLEYLR-DNDETSLPAVTL
| .   ||.|||||||  ||   |. ||.|| ..| |   .|..|| .||  .|||||.|.|||||| | |||.|||.|||||.||. .     .  | .
IILGHRLGEGQYGEVYKGIW--NNHRVAIKTIKDESMETKDFMKEAHIMKRMQHPNLVRLIGVCTREGPMYIVQEFMNYGNLLDYLQSPQSRIQIDHVSM

LYMATQVAFGMSYLEKNSFIHRDLAARNCLLGEHHLLKVADFGLARMVQGEIYTAQAGAKFPIKWTAPESLAYYKFSSKSDVWAFGILLWEIATYGCSPY
.. | |.| ||| ||   |||||||||||| |.    ||||||.||.|   .|.|  | |.||||||||||.|  |. |||||.||| ||||||||  ||
MHCAQQIADGMSFLEEQHFIHRDLAARNCLVGDNLQIKVADFGMARFVDSDFYEARIGTKMPIKWTAPESLCYDIFTIKSDVWSFGITLWEIATYGDVPY

PGVDLQHVYGKLEQGYRMERPEGCPTDVYKLMHKCWEWRHTDRPSFTEIHEEM
||..   |  .|. |||| ||..|| ..|  |  ||.     |||| .    .
PGIHHRDVINQLMMGYRMQRPQDCPMEIYNIMTQCWDVNPDERPSFHDLQHQL
Kinase Abl.AA Src 255-506 50 9.3e-134 450.67 In-house 1-255 (255) Show / Hide 
Range on Protein: 255-506
Range on HMM: 1-255/255
Sequence Identity: 50% (129 aa)

ISMKNKLGGGQYGEVYEAIWKKHNKIVAVKTLREENMRVDEFLREAAVMKNVKHPNLVQLLGVCTREPPFYIVTEFMPYGNLLEYLR-DNDETSLPAVTL
| .. ||| ||.|||....|... | ||||||.. .| .. ||.|| .||...|..||||. ||..| |.|||||.|  |.||.||. | .. .|.  .|
IKLCRKLGQGQFGEVWMGYWNGNTK-VAVKTLKPGTMSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRHLHLPQL

LYMATQVAFGMSYLEKNSFIHRDLAARNCLLGEHHLLKVADFGLARMVQ--GEIYTAQAGAKFPIKWTAPESLAYYKFSSKSDVWAFGILLWEIATYGCS
..||.||| ||.|||.. .||||||||| | ||. . |||||||||...   ..|.|. |||||||||||| . | .|. ||||| |||||.|| |||  
IDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGRV

PYPGVDLQHVYGKLEQGYRMERPEGCPTDVYK-LMHKCWEWRHTDRPSFTEIHEEM
|||| . . |  ..|.|||| .|..||  .|. .| .||. .  .|| |  ... .
PYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase Abl.AA TK 255-506 25 3.9e-121 408.05 In-house 1-486 (486) Show / Hide 
Range on Protein: 255-506
Range on HMM: 1-486/486
Sequence Identity: 25% (126 aa)

ISMKNKLGGGQYG---EVYEAIWKKHNK-------------------------IVAVKTLREE-NMRVDE--------------FLREAAVMKNVK----
| . .||| ||.|   |||...|. .|.                          ||||.|.|. .|  .|              ||.||..||  .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPNLVQLLGVCTRE------------PPFYIVTEFMPYGN----LLEYLRDNDET--------------------------------------------
 |||.|.|.||||..            .|..||.|.||.|.    |..|||.....                                            
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

------------------------------SLPAVTLLYMATQVAFGMSYLEKN------SFIHRDLAARNCLLGEHHL-----------LKVADFG---
                               |.  .|| |. |.| ||.||...       |.||||||||||.||..             |.||||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LARMV-QGEIYTAQA------------------------GAKFPIKWTAPESLA---------YYKFSSKSDVWAFGILLWEIATYG-CSPYPGV
     ||| . ... |...                         |.|.||.|.|||.|.         | ||..|||||.||.|.||| |||   .|.|.
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

DL---------QHVYGKLEQG--------------YRMERPEGCP--------------TDVYKLMHKCWEWRHTDRPSFTEIHEEM
.          | |. .|..|              .||..|..||              ...| || .||..   |||.|...||..
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase Abl.AA Src-Unclassified 255-510 41 1.5e-117 396.81 In-house 1-284 (284) Show / Hide 
Range on Protein: 255-510
Range on HMM: 1-284/284
Sequence Identity: 41% (119 aa)

ISMKNKLGGGQYGEVYEAIWKKHNKI-VAVKTLREE---NMRVDEFL--------REAAVMKNVKHPNLVQLLGVCTREPPFYIVTEFMPYGNLLEYLRD
.  . ||| || |||. ..|.  .|. |||||.|.     |    ||        .||..||  .|.|||.|..||..| |.||.||.|  | || .|| 
VHLLRKLGRGQFGEVWYGKWR--GKVDVAVKTMRPGHSETMSPEAFLHVKILNFCQEAQIMKKCRHQNLVHLYAVCSQEEPYYIITEYMINGSLLQWLRE

NDETSLPAVTL------------LYMATQVAFGMSYLEKNSFIHRDLAARNCLLGEHH-----LLKVADFGLA--RMVQGEIYTAQAGAKFPIKWTAPES
 . . |.   .             ..|.||| || ||| .  .|||||||| | |.       . ||.|||||  . .| ..| .  ||.||.||.||| 
GGGQYLHIQDMSEETGRKNVLIGVDIAAQVASGMMYLESKKYVHRDLAARNVLIGHNNSNGVPVVKVCDFGLARKKLMQDDNYCMRTGAMFPWKWMAPEC

LAYYKFSSKSDVWAFGILLWEIATYGCSPYPGVDLQHVYGKLEQGYRMERP--EGCPTDVYK-LMHKCWEWRHTDRPSFTEIHEEMNNMF
  | .|| ||||| .|||||||.|.|  |||| . . |   .| |||| .|  ..||  .|  .| |||  .   || |    .  .. |
FIYGNFSIKSDVWSYGILLWEIMTKGQTPYPGMHNREVLEHVERGYRMPKPTNHYCPDYIYEDIMKKCWHKDPQRRPTF----DTLYHYF
Kinase Abl.AA Tec 255-508 42 1.3e-110 373.75 In-house 1-254 (254) Show / Hide 
Range on Protein: 255-508
Range on HMM: 1-254/254
Sequence Identity: 42% (109 aa)

ISMKNKLGGGQYGEVYEAIWKKHNKIVAVKTLREENMRVDEFLREAAVMKNVKHPNLVQLLGVCTREPPFYIVTEFMPYGNLLEYLRDNDETSLPAV-TL
. .   || ||.| |  . |.  .  ||.|...|  |  ..|. || ||..  ||.|||| |||. . | |||||.|  | ||.||| .  .   ..  |
LTFMKELGSGQFGVVHLGKWRH-QYDVAIKMIKEGSMSEEDFIEEAKVMMKLSHPKLVQLYGVCSQQRPIYIVTEYMEHGCLLNYLREHKHHFQKNMAIL

LYMATQVAFGMSYLEKNSFIHRDLAARNCLLGEHHLLKVADFGLARMVQGEIYTAQAGAKFPIKWTAPESLAYYKFSSKSDVWAFGILLWEIATYGCSPY
|.|  .| .|| |||...|||||||||||| |. .  ||.|||..| |    ||   |.|||.|| .|| . | ..||||||||||.| ||. . |  ||
LEMCQDVCEGMAYLERHCFIHRDLAARNCLVGDQCVVKVSDFGMTRYVLDDQYTSSVGTKFPVKWCPPEVFHYSRYSSKSDVWAFGVLMWEVFSCGKMPY

PGVDLQHVYGKLEQGYRMERPEGCPTDVYKLMHKCWEWRHTDRPSFTEIHEEMNN
.  .   |  .  ||.|..||. |.. .|. | .||. .  .||.| .  ... .
ENMSNSEVVEHVSQGHRLYRPHLCSMHIYQIMYHCWHEKPEERPTFQQLLRQITE
Kinase Abl.AA Frk 255-510 49 8.4e-104 351.16 In-house 1-260 (260) Show / Hide 
Range on Protein: 255-510
Range on HMM: 1-260/260
Sequence Identity: 49% (129 aa)

ISMKNKLGGGQYGEVYEAIWKKHNKIVAVKTLREENMRVDEFLREAAVMKNVKHPNLVQLLGVCTREPPFYIVTEFMPYGNLLEYLR--DNDETSLPAVT
| .  .|| ||.|||.|  |   .  ||||||.   |  ..||||| .||...|| |.||  |||.| | ||.|| |  | |.|||.  ..   ..   .
IQLIRRLGSGQFGEVWEGLWNN-TTPVAVKTLKPGTMDPNDFLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKGRQCQMQQ

LLYMATQVAFGMSYLEKNSFIHRDLAARNCLLGEHHLLKVADFGLAR--MVQGE-IYTAQAGAKFPIKWTAPESLAYYKFSSKSDVWAFGILLWEIATYG
|. || ||| || |||.  .||||||||| |.|||  .|.|||||||  |.. | || .. ||.|||||||||   | ||. |||||.||||| || |||
LVDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGILLTEIITYG

CSPYPGVDLQHVYGKLEQGYRMERPEGCPTDVYKLMHKCWEWRHTDRPSFTEIHEEMNNMF
  ||||.  ..|   ...|||| .| .||  .|..| .||.     || |  ..  ... |
RMPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase Abl.AA UTK 255-506 37 3.2e-103 349.24 In-house 1-296 (296) Show / Hide 
Range on Protein: 255-506
Range on HMM: 1-296/296
Sequence Identity: 37% (110 aa)

ISMKNKLGGGQYGEVYEAIWKKHN-----KIVAVKTLREENM-RVD-----EFLREAA---VMKNVK-HPNLVQLLGVCTREPPFYIVTEFMPYGNLLEY
.   ..|| |..|||..| ... .      .||||..... . . .     .|..||.   .||... |||...|.||||.| |..||||.|. |.|. |
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LRDNDE------TSLPAVTLLYMATQVAFGMSYLEKNSFIHRDLAARNCLLGEHH-------LLKVADFG---LARMVQ----------GEIYTAQAGAK
||.. .      ..|   ..|.|| ..| ||.||.   |.||||||||||...|.       . |.||||   ..|.|.           . |.||   .
LRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDR

FPIKWTAPESLAYY-KFSSKSDVWAFGILLWEIATYGCSPYPGVDLQHVYGKLEQG--YRMERPEGCPTDVYKLMHKCWEWRHTDRPSFTEIHEEM
 ||.|.|||.|..  .|..|||||.||...||| |.|  ||||   . |   .. |  |||..|..|| .||.|||.||.    .||.| .. ..|
WPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase Abl.AA Csk 255-506 46 7.79999999999e-102 344.62 In-house 1-251 (251) Show / Hide 
Range on Protein: 255-506
Range on HMM: 1-251/251
Sequence Identity: 46% (118 aa)

ISMKNKLGGGQYGEVYEAIWKKHNKIVAVKTLREE-NMRVDEFLREAAVMKNVKHPNLVQLLGVCTREP-PFYIVTEFMPYGNLLEYLRDNDETSLPAVT
. .  . | | .| |   ...  |. |||| .... |  .. || ||.||   .|||||||.||   ..   |||.|.|  |||..|||   .. .    
LHLGECIGHGEFGDVMQGEYQ--NRKVAVKCIKCDGNGMAQAFLAEASVMTQLRHPNLVQLIGVILHQKNHLYIVMEYMSKGNLVDYLRSRGRHVITRRQ

LLYMATQVAFGMSYLEKNSFIHRDLAARNCLLGEHHLLKVADFGLARMVQGEIYTAQ--AGAKFPIKWTAPESLAYYKFSSKSDVWAFGILLWEIATYGC
||  |  |. || |||.. |.|||||||| |. |    || |||||.    | ..    .. |||||||||| |   |||.||||| ||||||||  .| 
LLKFAMDVCEGMCYLEQKKFVHRDLAARNILVSEDCVAKVSDFGLAKE---ECSQQDDSTSGKFPIKWTAPEALRHKKFSTKSDVWSFGILLWEIYSFGR

SPYPGVDLQHVYGKLEQGYRMERPEGCPTDVYKLMHKCWEWRHTDRPSFTEIHEEM
 ||| . |. |  . | ||||| |||||  |||.| .||.    .||.| .. | .
VPYPRIPLKDVVKHVEKGYRMEAPEGCPPHVYKVMKQCWHLNPAKRPTFRQVREQL
Kinase Abl.AA S_TKc 255-510 25 1.7e-57 198.22 SMART 1-231 (231) Show / Hide 
Range on Protein: 255-510
Range on HMM: 1-231/231
Sequence Identity: 25% (67 aa)

ISMKNKLGGGQYGEVYEAIWKKHNKIVAVKTLREENMRVDEFLREAAVMKNVKHPNLVQLLGVCTREPPFYIVTEFMPY--GNLLEYLRDNDE----TSL
  . .|.| | .|.|| ...|| ..|||.| ..      . ..|| ...|. .|||.|.|..|.     .|.|.|...   |.|..|....        .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

PAVTLLYMATQVAFGMSYLEKNSFIHRDLAARNCLLGEHHLLKVADFGLARMVQGEIYTAQAGAKFPIKWTAPESLAYYKFSS-KSDVWAFGILLWEIAT
|  .  ... |.. .. |. .. .|||||   | || |   .|..|||||| .                . ||| |   ...  |.|.|..|..|.| ..
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC

YGCSPYPGVDLQHVYGKLEQGYRMERPEGCPTDVYKLMHKCWEWRHTDRPSFTEIHE-----EMNNMF
 |. |.|  ..| .. |.            . ..  .. ||...  ..||.  |. .      .   |
-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase Abl.AA Pkinase 255-506 22 3e-50 178.07 Pfam 1-293 (293) Show / Hide 
Range on Protein: 255-506
Range on HMM: 1-293/293
Sequence Identity: 22% (66 aa)

ISMKNKLGGGQYGEVYEAIWKKHNKIVAVKTLREENMRVDE---FLR--EAAVMKNVKHPNLVQLLGVCTREPPFYIVTEFMPYG----NLLEYLRDNDE
.  . |.| | .|.||....|. .||||||... .. . ..    .|  |...||...||| |.|........  |.|.|... |     | .|..  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

TSL--PAVTLLYMATQVAFGMSYLEKNSFIHRDLAARNCLLGEHHLL----KVADFGLAR---MVQGEIYTAQAGAKFPIKWTAPESLA-YYKFSSKSDV
...  .  ..  ...|.. |. |. ....|||||   |.|. ..  .    |..|||||.      .. .|  .|  .   . ||| .  . . ..|.|.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPW---YMAPEVIRGGQYYGPKVDM

WAFGILLWEIATYGCSPYPGV-------DLQHVYGKLEQGYRMERPEGCP-------------------TDVYKLMHKCWEWRHTDRPSFTEIHEE--M
|..|..|.| .. |  |.||        ..| .. ...  .. ..|. |.                    .  ... .|...  ..||....| .   .
WSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
FABD Abl.AA FABD 887-1016 18 0.000673 -6.61 SMART 1-153 (153) Show / Hide 
Range on Protein: 887-1016
Range on HMM: 1-153/153
Sequence Identity: 18% (29 aa)

LRADKRGSVRKRG---------ISPIKNDSSV---GQGGKAEVLQMAEMLYAQTN---MLVQNGEYSKYSSELC---SELDNFFKQCTRHVDS--VMVKA
  .  . ..||           |  .  ...    .. .|  .|  .| |         |  . | .  .. .      . .  . |   .|.  .    
PQIMHKVALRKTRTQLTIYATPIAKLTQPAERIPSDKISKDMILECTECLCSAFHNLFNLATHSEQMVSHQQWLQMSDKGHQLHNYCMGYADCGIMQMHN

RFSFREILNSLESNTTLLRVRWSSAS---SSELERIIKDLHANVYVIRGIVQR
 | ||| .. || .   ||.  .||    | . .. .  ||  |  |  .|||
KFQFRELVTRLENQNRQLRFCSTSAGSRNSPNNNQDFMNLHSCVKEISDVVQR