Gene NEK2 (Sea Urchin)

NEK2

Species: Sea Urchin
Alias: SPU_005277, NEK2, Spk177
External Links: Sea Urchin Project Link ,
Annotation:

Classification

Group: Other
Family: NEK
Subfamily: NEK2

Sequence

Name Sequence Type Origin Length Description Download
NEK2.AA Protein None 453 None Fasta, JSON
NEK2.kin_dom Protein Kinase Domain None 263 None Fasta, JSON

Protein domain

Protein domains of NEK2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase NEK2.AA NEK2 8-270 56 5.4e-216 723.86 In-house 1-319 (319) Show / Hide 
Range on Protein: 8-270
Range on HMM: 1-319/319
Sequence Identity: 56% (180 aa)

YDILYTIGSGSYGKCRKVRRKSDGKILVSKEIDYGTMGEVEKQMLVSEVNLLRELKHEFIVRYYDRIVDRATSTIYIIMEYCEGGDLGSLISKCKKDRKF
|..|||||.||.|.||||||||||||||.|||.||.|.|.|.||||||.|.||.|||..||||||.|.||..||.||.|||||||||...|.||.|.|..
YEVLYTIGNGSFGRCRKVRRKSDGKILVWKEICYGHMQEKECQMLVSECNILRQLKHPNIVRYYDWIIDRQNSTLYIVMEYCEGGDLSQMIKKCRKERQY

LEESFAWKIFQQLTIALQECHR----------------RGKG-RAILHRDLKPANVFLDADHN-------------------------------------
.||.|.|.|..||..||||||.                |..| ..|||||.||||.|||.|||                                     
MEEEFIWRIMFQLCTALQECHNGVELPTLTTIYDRMKPRIDGKHTILHRDIKPANIFLDYDHNDYNINEQVDGHEEVNSNYYRDHRVNSGKRGSPMDYSQ

--VKLGDFGLARVLQHDTSFAKTFVGTPYYMSPEQMNRLSYNDKSDIWSLGCLLYELCSLSPPFTATNQAALAVKIKGGHFRRLPVQYSSDLNEIVSSML
  ||||||||||.|.||||||.||||||||||||||....||.||||||.|||.||.|.|.|||.|||||.|..|||.|||||.|.|||..||||...|.
VVVKLGDFGLARMLNHDTSFAHTFVGTPYYMSPEQMHGQKYNEKSDIWSVGCLIYEMCALHPPFQATNQAQLQEKIKQGHFRRIPYQYSRHLNEIIHFMI

KVKPSSRPSIDELLADPRL
.|....||||.|.|..|..
NVDHYHRPSIEEILQHPQI
Kinase NEK2.AA NEK 8-270 46 7.2e-154 517.48 In-house 1-286 (286) Show / Hide 
Range on Protein: 8-270
Range on HMM: 1-286/286
Sequence Identity: 46% (134 aa)

YDILYTIGSGSYGKCRKVRRKSDGKI-----LVSKEIDYGTMGEVEKQMLV-SEVNLLRELKHEFIVRYYDRIVDRATSTIYIIMEYCE-GGDLGSL---
|.|. .||.||.||. |||||||||.     .| |.|..| | | |||... .||..|..|||. ||.|||.....  ....|.||||| ||||  .   
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

ISKCKKDRKFLEESFAWKIFQQLTIALQECHRRGKG--RAILHRDLKPANVFLDADHN----VKLGDFGLARVLQHDTSFAKT-FVGTPYYMSPEQMNRL
| |.|. .|..||.  |..|.|. .||...| |  |  | |||||.||.|.||....|    ||.||||...||.|.|..|.| .||||||||||...  
IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRK-GPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNK

SYNDKSDIWSLGCLLYELCSLSP--PFTAT--NQAALAVKIKGG-HFRRLPVQ--YSSDLNEIVSSMLKVKPSSRPSIDELLADPRL
.|| |||||||||.|||.|.|.|  || |.  |. .|..||. | .. ..| .  ||.||....|.||.. |..|||....|..| .
PYNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase NEK2.AA NEK1 8-270 41 2.4e-93 316.45 In-house 1-276 (276) Show / Hide 
Range on Protein: 8-270
Range on HMM: 1-276/276
Sequence Identity: 41% (115 aa)

YDILYTIGSGSYGKCRKVRRKSDGKILVSKEIDYGTMGEVEKQMLVSEVNLLRELKHEFIVRYYDRIVDRATSTIYIIMEYCEGGDLGSLISKCKKDRKF
|... .||.||.||  .|..|.||. .| |||    |.| |..  . ||..|. .||. ||.|..  . .     ||.||||.||||   | . |   | 
YHYIKQIGEGSFGKAWLVKHKEDGQHYVIKEINVMKMQEKEREESMNEVAILAKMKHPNIVKYKESFEENGCGILYIVMEYCDGGDLMQKINRQKRKGKL

LEESFAWKIFQQLTIALQECHRRGKGRAILHRDLKPANVFLD--ADH---------------NVKLGDFGLARVLQHDTSFAKTFVGTPYYMSPEQMNRL
  |      | |. .||.  |     | |||||.|. |.||    .                 ||||||| ||.|.| ...|.| .||||| |||  . .
FSEDQIMHWFCQICLALNHIHD----RKILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGIARMLNHTMEYACTCIGTPYYLSPEICQNK

SYNDKSDIWSLGCLLYELCSLSPPFTATNQAALAVKIKGGHFRRLPVQYSSDLNEIVSSMLKVKPSSRPSIDELLADPRL
 || ||||||||| ||||| |. || | |  .|  ||  |..  .|  || .| . ||.|.|. |..|||.  .|  | .
PYNNKSDIWSLGCVLYELCTLKHPFEANNWKNLVLKICQGTYPPIPPHYSYELQSLVSQMFKRNPRHRPSVNQILERPFI
Kinase NEK2.AA S_TKc 8-270 33 2.4e-90 307.35 SMART 1-231 (231) Show / Hide 
Range on Protein: 8-270
Range on HMM: 1-231/231
Sequence Identity: 33% (92 aa)

YDILYTIGSGSYGKCRKVRRKSDGKILVSKEIDYGTMGEVEKQMLVSEVNLLRELKHEFIVRYYDRIVDRATSTIYIIMEYCEG--GDLGSLISKCKKDR
|.|| .||.|..||..|.| |..|.|   |.|.         ... .|...|.. .|..||..|| ..|   . .|..||||.|  ||| ..| |... .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG

KF--LEESFAWKIFQQLTIALQECHRRGKGRAILHRDLKPANVFLDADHNVKLGDFGLARVLQHDTSFAKTFVGTPYYMSPEQMNRLSYND-KSDIWSLG
.   . |  |.....|.  ||. ||..|    |.||||||.|..||   ..|..||||||.|       .||.|||.||.|| .   .|.  |.|.||.|
LRFPFPE-HARFYMYQICCALEYCHSHG----IIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCG

CLLYELCSLSPPFTATNQAALAVKIKGGHFRRLPVQYSSDLNEIVSSMLKVKPSSRPSIDELLA-------DPRL
|.|||...  |||   .....  ||.           |... .... .|.. |. ||.. |.|.       .| .
CILYEMLCGYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase NEK2.AA NEK8 8-270 34 1e-81 233.06 In-house 1-278 (278) Show / Hide 
Range on Protein: 8-270
Range on HMM: 1-278/278
Sequence Identity: 34% (98 aa)

YDILYTIGSGSYGKCRKVRRKSDG--KILVSKEIDYGTMGEVEKQMLVSEVNLLRELKHEFIVRYYDRIVDRATSTIYIIMEYCEGGDLGSLISKCKKDR
|    ..| |. | |   |||.|.  .  . |.|.   | | | ||  .|...|  | |  |. |||   .    |  | |||..|| |  .|..  .. 
YERIRVVGRGAFGICWLYRRKEDQSHHLVIWKQINMHRMSEKERQMAQNEIQVLSMLQHPNIISYYDHFME--DNTLMIEMEYADGGTLYQMIQH-QQNK

KFLEES----------------FAWKIFQQLTIALQECHRRGKGRAILHRDLKPANVFLDAD-HNVKLGDFGLARVLQHDTSFA--KTFVGTPYYMSPEQ
.|.||                      |.|  .|.   |  .    |||||||..|.|.. .   ||.||||.. ..  ... .  || |||||||||| 
LFEEERQLKQVNHCFNIYFNEQMILWYFFQMCSAVHHMHQHN----ILHRDLKTQNIFMTRHRMVVKIGDFGISKIMNTKYHMQTTKTVVGTPYYMSPEM

MNRLSYNDKSDIWSLGCLLYELCSLSPPFTATNQAALAVKIKGG-HFRRLPVQYSSDLNEIVSSMLKVKPSSRPSIDELLADPRL
    .|| |||.|.||| |||.|.|   | |.|. || .||  .  .  .. .||...   |.. |.. |  ||| ....|.| .
CEGKPYNQKSDMWALGCVLYEMCCLKRAFEASNLPALVWKIMQCRAYEPISDHYSNEMRMLVHNCLQQDPEQRPSASQIMAMPLC
Kinase NEK2.AA Pkinase 8-270 29 3.5e-72 250.9 Pfam 1-293 (293) Show / Hide 
Range on Protein: 8-270
Range on HMM: 1-293/293
Sequence Identity: 29% (90 aa)

YDILYTIGSGSYGKCRKVRRKSDGKILVSKEIDYGTMGEVEKQMLVS--EVNLLRELKHEFIVRYYDRIVDRATSTIYIIMEYCEGG----DLGSLISKC
| |. .|||||.|...| ..|..||| . |.|.. .  . ..| ..   |. ....|.|..|||.||   |   . ||..|||||||    || ..||  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYIST-

KKDRKFL--EESFAWKIFQQLTIALQECHRRGKGRAILHRDLKPANVFLDADHNV----KLGDFGLARVL-QHDTSFAKTFVGTPYYMSPEQMN-RLSYN
 .... .  .|  . ... |.  .|. ||..     |.||||||.|...| . ..    |..|||||...     | ..||.|||.||.||  . .  | 
-WRHGCFYFSEWECKFYMYQILRGLEYCHSM----GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYG

DKSDIWSLGCLLYELCSLSPPFTAT------NQAALAVKIKGGHFRRLPVQYS--------------------SDLNEIVSSMLKVKPSSRPSIDELLAD
 |.|.||.||.|||...  |||         .| .. ..|.|. ...   . .                    ... ......|...|..||.....| .
PKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQH

PRL
| .
PWF
Kinase NEK2.AA NEK4 8-270 39 1.9e-69 237.07 In-house 1-257 (257) Show / Hide 
Range on Protein: 8-270
Range on HMM: 1-257/257
Sequence Identity: 39% (104 aa)

YDILYTIGSGSYGKCRKVRRKSDGKILVSKEIDYGTMGEVEKQMLVSEVNLLRELKHEFIVRYYDRIVDRATSTIYIIMEYCEGGDLGSLISKCKKDRKF
|...  .| ||||    || . |.|  | | ..       |..    |..||  |||  || | .          ||.| .||||||     . |   .|
YCHMKVVGKGSYGEVWLVRHRRDKKQYVMKKMFLKNASRRERKAAEHEAQLLSQLKHPNIVEYKESWEIENGQFLYIVMGFCEGGDLYRKLKQQKN--QF

LEESFAWKIFQQLTIALQECHRRGKGRAILHRDLKPANVFLDADHNVKLGDFGLARVLQHDTSFAKTFVGTPYYMSPEQMNRLSYNDKSDIWSLGCLLYE
|||.     | |  .|||  |.    . |||||||  |.||     .|.||||..|||.    .||| .|||||||||      |. ||||||||| .||
LEEYQVVEWFVQIAMALQYMHE----KHILHRDLKTQNIFLTKKNIIKIGDFGISRVLNNHCDMAKTMIGTPYYMSPECFGNRPYDYKSDIWSLGCCVYE

LCSLSPPFTATNQAALAVKIKGGHFRRLPVQYSSDLNEIVSSMLKVKPSSRPSIDELLADPRL
.  |   | | .   |  .|  |.   .| .|| || ..|  ||. .|  |||| ...  | .
MITLKHAFDAKDMNSLIYQIIQGQPPPMPPNYSQDLQNLVYQMLEKQPTKRPSIFDIFQMPYI
Kinase NEK2.AA STE 8-270 21 6e-69 235.38 In-house 1-359 (359) Show / Hide 
Range on Protein: 8-270
Range on HMM: 1-359/359
Sequence Identity: 21% (81 aa)

YDILYTIGSGSYGKCRKVRRKS---------------DGKILVSKEIDYGTMG---------------EVEKQMLVSEVNLLRELK--HEFIVRYYDRIV
....  ||.|..|.  | ...                 |.|   |.... .                 . |.| .  |........  |..||.||.  .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

-----DRATSTIYIIMEYCEGGDLGSLIS---KCKKDRK-------FLEESFAWKIFQQLTIA-LQECHRRGKGRAILHRDLKPANVFLDADHNVKLGDF
     . . ....|.|||..|| | ..|    .|.|. .       ...||   .| .|.  . |.  |. .    | |||.||||..|     ||| ||
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH----IIHRDIKPANILL-----VKLCDF

GLARVLQH---------------DTS-FAKTFVGTPYYMSPEQMNR------LSYNDKSDIWSLGCLLYELCSLSPPFTATNQA-ALAVKIKG-------
|..  |..               ...   .|||||| .|.|| ...        |. |.|||||||.. |..   ||.   .   |.  ....       
GVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQF

-------GHFRRLPV-------------------QYSSDLNEIVSSMLKVKPSSRPSIDELLA--DPRL
       |.  .||                    ..|..... ..  |.  |. ||. ..||    | .
EQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase NEK2.AA Ciliate-E2 8-270 21 1.1e-63 217.51 In-house 1-365 (365) Show / Hide 
Range on Protein: 8-270
Range on HMM: 1-365/365
Sequence Identity: 21% (84 aa)

YDILYTIGSGSYG-----KCRKVRR------------------KSDGKILVSKEIDYG---TMGEVEKQM---------LVSEVNLLRELKHEFIVRYYD
|...  ||.|..|     | .||..                  | ..||   | .       .  ....|         .  | |.|..|.| .|...|.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKI-NEKNILEQLNHPNIIKMYE

RIVDRATSTIYIIMEYCEGGDLGSLISKCKKDRKFL-------EESFAWKIFQQLT---------------IALQECHRRGKGRAILHRDLKPANVFLDA
   .  ...||..||||.|||| ..| ..|| |..         |  . .|..|..                ||...| ...   |.|||.|| |...  
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNN---IIHRDIKPENILF--

DHNVKLGDFGLAR---------------VLQHDTS-----------------FAKTFVGTPYYMSPEQMNRLS---------YNDKSDIWSLGCLLYELC
   .|. ||||..                .  . .                  ..|..|||.||.||  |. .         |. |.||||||..|||..
---IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEML

SLSPPFTATNQAALAVKIKGGHFRRL-----------------PVQYSSDLNEIVSS----MLKVKPSSRPS-IDELLADPRL
.  |||          .|| . ..                   . . | .   . .     ||...|. |.. ....|  | .
FGKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase NEK2.AA ULK 8-270 27 2.6e-63 216.64 In-house 1-329 (329) Show / Hide 
Range on Protein: 8-270
Range on HMM: 1-329/329
Sequence Identity: 27% (93 aa)

YDILYTIGSGSYGKCRKVR-RKSD---GKILVSKEIDYGTMGEVEKQ--------MLVSEVNLLRELK----HEF----IVRYYD-RIVDRATSTIYIIM
| .   .|.||.||  | |  |..   ... . | ||  .| . ...        .| .|. ....||    |..    ||..||    .     |||||
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNH-NNIYIIM

EYCEGGDLGSLISKCKK------DRKFLEESFAWKIFQQLTIALQECHRRGKGRAILHRDLKPANVFLDADHN------------VKLGDFGLARVLQHD
|||.|||| ..|.| ||        |.|.|. | ..|.|.  ...| | ..    | |||.||.|. .. .              .|..|||.|.... |
EYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHN----IIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDND

---TSFAKTFV------GTPYYMSPEQMNRL----SYNDK-SDIWSLGCLLYELCSLSPPFTATNQAALAVKIKGGHFR--------------RLP----
      ..|.|      |||.||.|.  ...     |.|. .|||||||..||.    ||| |     .  .|.   ..              . |    
NMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGN

-VQYSSDLNEIVSSMLKVKPSSRPSIDELLADPRL
 .| |... .. . ||..... | |..||.. | .
DPQISPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase NEK2.AA Ciliate-E2-Unclassified 8-270 23 2.3e-62 213.5 In-house 1-352 (352) Show / Hide 
Range on Protein: 8-270
Range on HMM: 1-352/352
Sequence Identity: 23% (84 aa)

YDILYTIGSGSYGKCRKVRRKSDGKI------LVSKEIDYGTMGE----------VEKQMLVSEVN--------LLRELKHEFIVRYYDRIVDRATSTIY
| |...||.|..|| .|...|.....       ......   . .          .....  . ..        .|. ..|.|||....  ... . .||
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKK-YHQRKYNKIMQQILLNHPHPFIVKMFY--CFQDKQNIY

IIMEYCEGGDLGSLISKCKK-------------DRKFLEESFAW-----KIFQQLTIALQECHRRGKGRAILHRDLKPANVFLDADH---NVKLGDFGLA
|.|||||||||   |.|.||              || ..|  |      ..| |.  .|. .|. .    |.|||.|| |...| ..   ..|. |||..
IVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKN---NIIHRDIKPENILFDNNGKNYYIKIIDFGIS

RVLQHD---------------TSFAKTFVGTPYYM----SPEQMNRLSYNDK----SDIWSLGCLLYELCSLSPPFTATNQAA----------------L
. .| .                  ..||.|||.||    .|| . .  |...    .||||||..|||..   .|| ..|.                  |
KKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQL

AVKIKGGHFRRLP-------VQYSSDLNEIVS----SMLKVKPSSRPSIDELLADPRL
  .|| . .   .        . |    ....    .|||..|..|......|  | .
YQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase NEK2.AA ULK 8-270 27 1.1e-60 207.9 In-house 1-324 (324) Show / Hide 
Range on Protein: 8-270
Range on HMM: 1-324/324
Sequence Identity: 27% (90 aa)

YDILYTIGSGSYG-KCRKVR-RKSD--GKILVSKEIDYGTMGEVEKQ--------MLVSEVNLLRELK---HEF--IVRYYDRIVDRATSTIYIIMEYCE
| .   .|.||.| |  | |  |..  ...   | ||   | . ...        .| .|......||   |..  ||..||   .     ||||||||.
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

GGDLGSLISKCKK-----DRKFLEESFAWKIFQQLTIALQECHRRGKGRAILHRDLKPANVFLDADHN------------VKLGDFGLARVLQHDT---S
|||| ..| | ||       |.|.|. | ..|.|.  ...| | ..    | |||.||.|  .  .              .|..|||.|.... ..    
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHN----IIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQ

FAKTFV------GTPYYMSPEQMNRL----SYNDK-SDIWSLGCLLYELCSLSPP----FTATN------------QAALAVKIKGGHFRRLP--VQYSS
  .|.|      |||.||.|.  ...     |.|. .|||||||..||.   ..|    |. ..            |  . .| .   |.  |  .. |.
MCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSWFNDQYLYIQKLINNGKEQ-QIYIKNQPIQFPKPPKDPKISP

DLNEIVSSMLKVKPSSRPSIDELLADPRL
.. .. . ||..... | |..|... | .
ECKDLIRRMLQYDEKDRISWEEIFNHPWF
Kinase NEK2.AA TyrKc 8-268 20 1.2e-16 46.65 SMART 1-280 (280) Show / Hide 
Range on Protein: 8-268
Range on HMM: 1-280/280
Sequence Identity: 20% (62 aa)

YDILYTIGSGSYGKCRKVRRKSDGKILV----SKEIDYGTMGEVEKQMLVSEVNLLREL--KHEFIVRYYDRIVDRAT-----STIYIIMEYCEGGDLGS
   . ..|.| .|. .| . |    | |     ||          .... .| .....|  .|. ||| |  ...          ..|.|||...||| .
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA--------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

LISKCKKDRKFLEESFAWKIFQQLTIALQ--------ECHRRGKGRAILHRDLKPANVFLDADHNVKLGDFGLARVLQHD-------TSFAKTF-VGTP-
 . |....          .  . | ...|        . .       . ||||   |. ....| || .||||.| . .|           |.   |.  
YLRKHRPK---------LCMKDLLSFCWQIACGMEYLHSK------NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKT

----YYMSPEQMNRLSYNDKSDIWSLGCLLYELCSL-SPPFTA-----TNQAALAVKIKGGHFRRLPVQ--------YSSDLNEIVSSMLKVKPSSRPSI
      |.|| .|   .. |||.|| | ...|....  .|         . . .  ..| |. .. |           .... .| ..  . .|..||. 
MLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTF

DELLADP
 |.  . 
SEIHECF
Kinase NEK2.AA Pkinase_Tyr 48-94 31 2e-06 22.58 Pfam 44-94 (270) Show / Hide 
Range on Protein: 48-94
Range on HMM: 44-94/270
Sequence Identity: 31% (16 aa)

E--KQMLVSEVNLLREL-KHEFIVRYYDRIV-DRATSTIYIIMEYCEGGDL
.  .... .|......| .|. |||.|  .. ..  . |||.|||...|||
QNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDL
Kinase NEK2.AA Pkinase_Tyr 182-211 40 4.3e-05 17.86 Pfam 181-210 (270) Show / Hide 
Range on Protein: 182-211
Range on HMM: 181-210/270
Sequence Identity: 40% (12 aa)

MSPEQMNRLSYNDKSDIWSLGCLLYELCSL
|.|| .|   .. |||.|| | |..|....
MAPECINYGKFTTKSDVWSFGVLMWEIFTY
Kinase NEK2.AA Pkinase_Tyr 136-168 42 0.000177 15.79 Pfam 132-164 (270) Show / Hide 
Range on Protein: 136-168
Range on HMM: 132-164/270
Sequence Identity: 42% (14 aa)

ILHRDLKPANVFLDADHNVKLGDFGLARVLQHD
. ||||   |. .. .. || .|||||| ...|
CIHRDLAARNCLVTENNVVKICDFGLARDIYND