Gene ERK7 (Sea Urchin)
ERK7
Sequence
Protein domains of ERK7.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | ERK7.AA | ERK7 | 1-235 | 66 | 1.5e-155 | 523.06 | In-house | 57-292 (292) | Show / Hide |
Range on Protein: 1-235 Range on HMM: 57-292/292 Sequence Identity: 66% (158 aa) DHKNIVKLLNVMRAENDKDIYLVFEYMDTDLHAVIKKGGILKDIHKRYIMYQLINATMYMHSGNVIHRDQKPSNILLDTECFVKVADFGLARSITQIDAV .| ||..|.||.||.||.|||||||.|.|||||||.|| |||||||.||||||..|. |||||||||||.||||||||.||.|||.||||||||.|.... CHPNIIRLINVIRADNDRDIYLVFEFMETDLHAVIRKGNILKDIHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDFGLARSIAQQEEY LSEDNPALTEYVATRWYRAPEILLASKRYTKGVDMWSVGCIIGELLKGKPMFPGSSTFNQLERIMAIIDPPTKKDIEAIQSDYXXX---XXXXRHRQSIE .|.||.|||||||||||||||||.|.||||||||||.|||.||.|.|||||||.||.||.|.|. .| ||..|||||.|.| ..|.... -DEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMWSIGCILGEMLRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMNQQKRKTLD EVLPXGAPADAIDLVRKLLHFNPDKRLTAKQALSHPYV ...| ... |||||...|| |||.|||||.|||.|||| QMMP-QCCDDAIDLLKRLLVFNPKKRLTAEQALQHPYV |
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Kinase | ERK7.AA | MAPK | 1-235 | 43 | 6.4e-126 | 424.62 | In-house | 63-328 (328) | Show / Hide |
Range on Protein: 1-235 Range on HMM: 63-328/328 Sequence Identity: 43% (116 aa) DHKNIVKLLNVMRAE-----ND----KDIYLVFEYMDTDLHAVIKKGGILKDIHKRYIMYQLINA--TMYMHSGNVIHRDQKPSNILLDTECFVKVADFG .|.||.|||.....| |. .|||.|.|.|.||||..|| . .| |.|..|.|||.... |.||.|||||| ||||||....| .|..||| HHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMETDLHQIIKSQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFG LARSITQI-DAVLSEDNP------ALTEYVATRWYRAPEILLA--SKRYTKGVDMWSVGCIIGELLK-GKPMFPGSSTFNQLERIMAIIDPPTKKDIEAI ||||| . ..|.| .||||||||||||||.| ...|||.||||||||| .|.|. .||.|||... .|...||... |.. .|. | LARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAPEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCI Q-S----DYXXXX--XXXRHRQSIEEVLPX---GAPADAIDLVRKLLHFNPDKRLTAKQALSHPYV . | .| . ... |...| .| .||||. |.|.|.||||.|...||.|||. CMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANPQAIDLLEKMLVFDPDKRITVEEALQHPYF |
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Kinase | ERK7.AA | CMGC | 1-235 | 24 | 2.4e-103 | 340.54 | In-house | 96-513 (513) | Show / Hide |
Range on Protein: 1-235 Range on HMM: 96-513/513 Sequence Identity: 24% (103 aa) DHKNIVKLLNVMRAEN---------------DKDIYLVFEYMDTDLHAVIKKGG---------ILKDIH------------KRYIM------YQLINATM .|.|||||... . .| ....||||||||.||. .||. |.. | ..|.| ||.... HHNNIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLK --YMHSGN--VIHRDQKPSNILLDTECFV--------------------KVADFGLARSITQIDAVLSEDNP--------------ALTEYVATRWYRAP |.|| . .|||| ||.|||.. .| . |..||||||.. . . . ...| ..|.||.||||||| LKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAP EILLASKRYT---------KGVDMWSVGCIIGELLKG--------KPMFP-----------GSSTFNQLERIMAIIDPPT---------------KKDIE |||| .|.|| ...||||||||..|.. | ||.|| |.|. .||..|. .. .|| .... EILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWP AIQSDYXXXX---------------------------XXXRHRQSIEEVLPX----------------------------------GAPADAIDLVRKLL . . . ......... | .. .||||. |.| NMIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKML HFNPDKRLTAKQALSHPYV ...||||.||.|||.||| QYDPDKRITAEQALQHPYF |
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Kinase | ERK7.AA | CDK | 2-235 | 35 | 5.9e-79 | 252.21 | In-house | 66-284 (284) | Show / Hide |
Range on Protein: 2-235 Range on HMM: 66-284/284 Sequence Identity: 35% (92 aa) HKNIVKLLNVMRAEN---------DKDIYLVFEYMDTDLHAVIKKGGILKDIHKRYIMYQLINATMYMHSGNVIHRDQKPSNILLDTECF-----VKVAD |.|||||. | .| .. .|.||||||.|| ... . .|.||... |.|| ...||| ||.|||.. .|.|| HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEYMDHDLKKYMD---------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIAD FGLARSITQ--IDAVLSED-NPALTEYVATRWYRAPEILLASKRYT--KGVDMWSVGCIIGELLK---GKPMFPGSSTFNQLERIMAIIDPPTKKDIEAI ||||| | . | ..| | |.||||||.|| ||.|. ..||||||||..|.. .||.|||.| .||..| |. || .. . FGLARAFGIPHQ---MS-EPNRTYTHEVVTLWYRAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGV QS--DYXXXXXXXRHRQSIEEVLPXGAPADAIDLVRKLLHFNPDKRLTAKQALSHPYV . || || |.| ..|.||..|.|||.||| TKLPDY--------------------------DLLNKMLCYDPKKRISAEQALQHPYF |
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Kinase | ERK7.AA | ERK | 2-182 | 46 | 9.6e-79 | 267.92 | In-house | 63-248 (307) | Show / Hide |
Range on Protein: 2-182 Range on HMM: 63-248/307 Sequence Identity: 46% (86 aa) HKNIVKLLNVMRAE---NDKDIYLVFEYMDTDLHAVIKKGGILKDIHKRYIMYQLINATMYMHSGNVIHRDQKPSNILLDTECFVKVADFGLARSIT-QI |.||..|...|. . . .|||.|.|.|.|||| .|. | | | | |||.... |.|| |||||| ||||||. | |..|||||| . . HENIICLFDIMMPNSPEQYNDIYCVEELMETDLHQIINSQQELSDDHCQYFMYQILCGLKYIHSANVIHRDLKPSNILVNSNCDLKICDFGLARCFDASY DAVLSEDNPALTEYVATRWYRAPEILLASKRYTKGVDMWSVGCIIGELLKGKPMFPGSSTFNQLERIMAIIDPP-TKKDIEAIQSD . .. .. .||||||||||||||.| . ||| .|.||.|||. |.|..||.||| .. .|..|| .|| | .. |.. |.|. QENHECNQNFMTEYVATRWYRAPEIMLSWQKYTKAMDIWSCGCIFAEMLGRKPLFPGKDYVHQINRIFQIIGTPHSEEDLQYICSE |
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Kinase | ERK7.AA | p38 | 1-235 | 39 | 2.2e-71 | 243.23 | In-house | 59-289 (289) | Show / Hide |
Range on Protein: 1-235 Range on HMM: 59-289/289 Sequence Identity: 39% (95 aa) DHKNIVKLLNVMRA-----ENDKDIYLVFEYMDTDLHAVIKKGGILKDIHKRYIMYQLINATMYMHSGNVIHRDQKPSNILLDTECFVKVADFGLARSIT .| |...||.| .. .|.|.| . |..||. ..| | | | ... ||.. . | || ..|||| ||||| . .| ... |||||| RHENVICLLDVFTPPAHSMNDFQDVYMVTHFMGADLNNIMKCQR-LSDDHIQFLVYQILRGLKYIHSAGIIHRDLKPSNIAVNEDCELRILDFGLAR--- QIDAVLSEDNPALTEYVATRWYRAPEILLASKRYTKGVDMWSVGCIIGELLKGKPMFPGSSTFNQLERIMAIIDPPTKKDIEAIQSDYXX---XXXXXRH . .|.||||||||||||.| .||. ||.||||||. ||. |.. |||. .||.|||... |.. .. |||. . -------HCDDEMTGYVATRWYRAPEIMLNWMHYTQTVDIWSVGCIMAELITGRTLFPGDDHIDQLQRIMKVCGTPDEEFWQKIQSEEARNYIQSYPQMP RQSIEEVLPXGAPADAIDLVRKLLHFNPDKRLTAKQALSHPYV |. ..|.. || |||| |.|. ||||.||..|..||| RRDFHHVFM-GANPQAIDLLEKMLELDPDKRITAEEAMQHPYF |
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Kinase | ERK7.AA | Pkinase | 1-235 | 30 | 2.8e-71 | 247.92 | Pfam | 58-293 (293) | Show / Hide |
Range on Protein: 1-235 Range on HMM: 58-293/293 Sequence Identity: 30% (78 aa) DHKNIVKLLNVMRAENDKDIYLVFEYMDT-----DLHAVIK--KGGIL--KDIHKRYIMYQLINATMYMHSGNVIHRDQKPSNILLDTECFV----KVAD .|.|||.|. ... ...||.|.||.. ||...|. ..| . . . . .|||.. . |.|| ..|||| ||.|||.| .. . |..| NHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICD FGLARSITQIDAVLSEDNPALTEYVATRWYRAPEILLASKRYTKGVDMWSVGCIIGELLKGKPMFPGS----STFNQLERIMAIIDPPTKKDIEAIQSDY ||||. . |. .| .. |.||.|||... .. |.. |||||.|||. |.| |.| |||. . .|...| | .||.. |.. | . FGLAKQFD------Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSIS XXXXXXXRHRQSIEEVLPXGAPADAIDLVRKLLHFNPDKRLTAKQALSHPYV .... .. ...|.....|...| ||.||.|.| ||.. YFF-FRH-W-HF-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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Kinase | ERK7.AA | RCK | 2-235 | 35 | 5.8e-71 | 224.32 | In-house | 57-298 (298) | Show / Hide |
Range on Protein: 2-235 Range on HMM: 57-298/298 Sequence Identity: 35% (90 aa) HKNIVKLLNVMRAENDKDIYLVFEYMDTDLHAVIKK---GGI-LKDIH--KRYIMYQLINATMYMHSGNVIHRDQKPSNILLDT---------ECFVKVA |.||.||. | | ... |.||||||..| .| .. | . . ||||.. . .||. . ||| || ||.. .|.| HPNIIKLKEVIRDNDTYQLYFVFEYMDMNLYQMMKDFKERRKYLPENQRSIKNIMYQILQGLAHMHKHGFFHRDLKPENIMCTGSQQYFEDQDQDHIKIA DFGLARSITQIDAVLSEDNPALTEYVATRWYRAPEILLASKRYTKGVDMWSVGCIIGELLKGKPMFPGSSTFNQLERIMAIIDPPTKKD-IEAI-QSDYX ||||.|.| ...| |.|| ||||||||.|| . |.. .|.|.||||. || .|.||||| |. | .. |.||| ... .. DFGLCREI--------RSKPPYTDYVSTRWYRAPECLLRCTYYNSPMDIWAVGCIMYELYMLRPLFPGSSEIDQIFKICKVMGTPNKKDWPDGYKLASQM XXXXXXRHRQSIEEVLPXGAPADAIDLVRKLLHFNPDKRLTAKQALSHPYV . .......| .. |.|.|..|.| .|.|| ||.||| ||| NFNFPQCKGMPLKQLIPN-CSQDCIELMEKMLQWDPQKRITAQQALQHPYF |
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Kinase | ERK7.AA | ERK1 | 2-235 | 42 | 4.6e-67 | 229.11 | In-house | 56-289 (289) | Show / Hide |
Range on Protein: 2-235 Range on HMM: 56-289/289 Sequence Identity: 42% (101 aa) HKNIVKLLNVMRA---ENDKDIYLVFEYMDTDLHAVIKKGGILKDIHKRYIMYQLINATMYMHSGNVIHRDQKPSNILLDTECFVKVADFGLARSITQID | ||... ...|| |. .|.|.| . |.||| ..| . | | | .||.. |.|| ||.||| ||||.|| | | .|. |||||| |. . HENIINIQDIIRADTIEQMRDVYIVQCLMETDLYKLLKTQHLSND-HICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLAR-IADPE AVLSEDNPALTEYVATRWYRAPEILLASKRYTKGVDMWSVGCIIGELLKGKPMFPGSSTFNQLERIMAIIDPPTKKDIEAIQSDYXXXXXX---XRHRQS . |||||||||||||||.| || ||| .|.||||||. |.| .|.||| || |.... | ..|.. | . . ... H---DHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGVLGSPSQDDLNCIINEKARNYLQSLPHKPKVP IEEVLPXGAPADAIDLVRKLLHFNPDKRLTAKQALSHPYV ... | .| . |.||. |.| |||.||.| .|| |||. WARLFP-KADSKALDLLDKMLTFNPHKRITVEEALAHPYL |
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Kinase | ERK7.AA | ERK5 | 18-235 | 40 | 1.8e-64 | 220.52 | In-house | 77-295 (295) | Show / Hide |
Range on Protein: 18-235 Range on HMM: 77-295/295 Sequence Identity: 40% (90 aa) KDIYLVFEYMDTDLHAVIKKGGILKDIHKRYIMYQLINATMYMHSGNVIHRDQKPSNILLDTECFVKVADFGLARSITQIDAVLSEDNPALTEYVATRWY ||.| ||. |. ||| .| . | || .||.. |||| .||||| ||||.| | .|. |||.|| .. . . . .||||||||| KDVYVVFDLMESDLHQIIHSNQPFTLEHIRYFLYQILRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTFSP--DKHQMFMTEYVATRWY RAPEILLASKRYTKGVDMWSVGCIIGELLKGKPMFPGSSTFNQLERIMAIIDPPTKKDIEAIQSDYXXXXXXX----RHRQSIEEVLPXGAPADAIDLVR ||||....|. ||. .|.||||||.||.. . |||| .||. || .. | . |.|. .| | . .|.| | .| |.||. RAPELMFSSHDYTQAIDVWSVGCIFGEMIARRQMFPGKNYIHQLQLIMMVLGMPPPHMIQAVSADHVYNYFQKNFPNRQPKDWEKVYP-KADRQALDLLA KLLHFNPDKRLTAKQALSHPYV ..| | | .|.|. .|| ||.. RMLRFEPSERITVNKALQHPFL |
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Kinase | ERK7.AA | S_TKc | 1-235 | 29 | 1.1e-43 | 152.33 | SMART | 19-231 (231) | Show / Hide |
Range on Protein: 1-235 Range on HMM: 19-231/231 Sequence Identity: 29% (83 aa) DHKN---------------------------IVKLLNVMRAENDKDIYLVFEYMDT---DLHAVIKKGGI------LKDIHKRYIMYQLINATMYMHSGN ||. ||||. |.. ...|.|.||.|. ||. .||| | . | |..|||...| |.|| . RHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHG VIHRDQKPSNILLDTECFVKVADFGLARSITQIDAVLSEDNPALTEYVATRWYRAPEILLASKRYTK-GVDMWSVGCIIGELLKGKPMFPGSSTFNQLER .|||| ||.|||||. .|..|||||| . | .. |.||.|||.| |.| .|.||.|||. |.| |.| || |... IIHRDLKPENILLDE--HIKICDFGLARQL--------------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEMLCGYPPFP------QMQM IMAIIDPPTKKDIEAIQSDYXXXXXXXRHRQSIEEVLPXGAPADAIDLVRKLLHFNPDKRLTAKQALS-------HPYV .. .| . .|.|..||.|...|.||.|| .|| ||.. MFKKIG-----------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | ERK7.AA | MAPK-Unclassified | 108-235 | 30 | 1.1e-34 | 121.52 | In-house | 405-575 (575) | Show / Hide |
Range on Protein: 108-235 Range on HMM: 405-575/575 Sequence Identity: 30% (52 aa) LTEYVATRWYRAPEILLASKRYTKGVDMWSVGCIIGELLKG-----------KPMFPGSS--------------------TFNQLERIMAIIDPPTKKDI .|.||.|||||||||.| .. |.. ||.||.||| .|.. .|.|||.. |. | | . |. MTQYVVTRWYRAPEIMLSMHEYDTQVDIWSIGCIFAEMMQMYDRHNPTFSDHRPLFPGQDCFPITPDRNNDVDQGGFPHSHQDQIKMIFDYLGMPPEEDC EAIQSDYXXXXXXXRHRQSIEEVL---PXGAP---------ADAIDLVRKLLHFNPDKRLTAKQALSHPYV |..| . .. . || ..||.| |.| ||| || || |||.|||. NFITCDSARKYIQSFKCKTPVHFTDLMFCKAPGDDQIVRGNCECIDFVQKMLQFNPWKRITADQALEHPYF |
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Kinase | ERK7.AA | MAPK-Unclassified | 2-94 | 37 | 3.2e-31 | 109.9 | In-house | 58-159 (575) | Show / Hide |
Range on Protein: 2-94 Range on HMM: 58-159/575 Sequence Identity: 37% (38 aa) HKNIVKLLNVMRAENDKD-----IYLVFEYMDT---DLHAVIKKGG-ILKDIHKRYIMYQLINATMYMHSGNVIHRDQKPSNILLDTECFVKVADFGLAR | ||... .. ... .. ||.| .|| | ||| .|| . ..| .|..||. . |.|| ..|||| ||||.|.. | |...|||..| HPNIIQIQDIFYNKELHNQEFDDIYIVMDYMQTSLFDLHQIIKSNQDHWCHQHIQYFFYQILRGLKYLHSACIIHRDLKPSNLLINQDCSVRICDFGMSR SI || SI |
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Kinase | ERK7.AA | ERK | 204-235 | 50 | 4.1e-15 | 52.87 | In-house | 274-307 (307) | Show / Hide |
Range on Protein: 204-235 Range on HMM: 274-307/307 Sequence Identity: 50% (17 aa) AP--ADAIDLVRKLLHFNPDKRLTAKQALSHPYV |. .|||| .|.|.|.||||.|....|.||| ANCNPQAIDLLEKMLVFDPDKRITVEECLEHPYF |
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Kinase | ERK7.AA | TyrKc | 1-183 | 16 | 3.5e-07 | -106.58 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 1-183 Range on HMM: 1-280/280 Sequence Identity: 16% (48 aa) D-------------------------------------------------HKNIVKLLNVMRAE-----NDKDIYLVFEYMDT-DLHAVIKKGGI-LKDI |.|||.|. | . . .. ...|.|||. ||. ..| . |. ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMK HKRYIMYQLINATMYMHSGNVIHRDQKPSNILLDTECFVKVADFGLARSITQI---DAVLSEDNPA----LTEY-VATRWYRAPEILLASKRYTKGVDMW .. ....| . | || |.|||| |.|.. . ||..||||.| |. . .. . . . . ||. ||| . ...| | | DLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG-ESKDYYRKKEHKGGKTMLPIRWM-APECI-NYGKFTTKSDVW SVGCII------GELLKGKP---MFPGSSTFNQLERIMAIIDPPT---------------------KK------DIEAIQSDY | | . |. . | . . ...... . || . ..| .. SFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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Kinase | ERK7.AA | Pkinase_Tyr | 74-94 | 52 | 7.1e-05 | 17.14 | Pfam | 141-161 (270) | Show / Hide |
Range on Protein: 74-94 Range on HMM: 141-161/270 Sequence Identity: 52% (11 aa) NILLDTECFVKVADFGLARSI |.|.. . .||..|||||| | NCLVTENNVVKICDFGLARDI |
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Kinase | ERK7.AA | Pkinase_Tyr | 1-69 | 32 | 0.008422 | 10.11 | Pfam | 62-136 (270) | Show / Hide |
Range on Protein: 1-69 Range on HMM: 62-136/270 Sequence Identity: 32% (24 aa) DHKNIVKLLNVMRAENDK-DIYLVFEYMDT-DLHAVIKK----GGILKDIHKRYIMYQLINATMYMHSGNVIHRD .|.|||.|. | . . ||.|.||| ||. .| .. |. .. . .| .. | .| | |||| HHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRD |