Gene 17822 (Tetrahymena)

17822

Species: Tetrahymena
Alias: 304, PreTt17822, 146.m00123, TTHERM_00840070, 3743.m00052, 17822
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: WNK

Sequence

Name Sequence Type Origin Length Description Download
17822.AA Protein None 2253 None Fasta, JSON
17822.kin_dom Protein Kinase Domain None 174 None Fasta, JSON
17822.NA RNA None 6762 None Fasta, JSON

Protein domain

Protein domains of 17822.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 17822.AA WNK 111-277 59 5e-131 425.55 In-house 93-261 (261) Show / Hide 
Range on Protein: 111-277
Range on HMM: 93-261/261
Sequence Identity: 59% (100 aa)

LKKIKKPRLKIIKQWCKQILSGLQYLHEQEPHPIIHRDIKCENIFVNTVNNEIRIGDLGLALTLK-SDFTTSVLGTPEFMAPEIYEEKYGTAVDIYAFGM
||  || . |. ..||.|||.||..||...||||||||.||.|||.........|||||||.||| |.|..||.|||||||||.|||.|...||.|||||
LKRFKKMKPKVLRSWCRQILKGLHFLHTRQPHPIIHRDLKCDNIFITGTTGSVKIGDLGLAVTLKNSSFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGM

CLLEMATLQIPYRECTSAAQVYKKVSQGLLPNSLQLIQNDSLKQFILKCIQRSE-NRPSAAQLLQDDFF
|.|||||...||.||..|||.|.||.||..|||.|.|||...|..|.|||.... .|||..|||..|||
CMLEMATSEYPYSECQNAAQIYRKVTQGIKPNSFQKIQNPEVKEIIEKCIRHNKEERPSIQQLLNHDFF
Kinase 17822.AA STE11 127-277 30 2.7e-41 143.51 In-house 123-303 (303) Show / Hide 
Range on Protein: 127-277
Range on HMM: 123-303/303
Sequence Identity: 30% (57 aa)

KQILSGLQYLHEQEPHPIIHRDIKCENIFVNTVNNEIRIGDLGLALTLKSDFTT------------SVLGTPE--------FMAPEIYE-EK---YGTAV
||||.||||||..    ||||||| .||.... .| ....| | |  |... |.            |. |||         .||||..  |.   ||...
KQILEGLQYLHSHG---IIHRDIKGANILLDSDGNVCKLADFGCAKRLAWICTCTHNMNMTQNHCKSMTGTPYNSMMGTPMWMAPEVIKQEGRDGYGRKA

DIYAFGMCLLEMATLQIPYRECTS--AAQVYKKVSQ-GLLPNSLQLIQN-----DSLKQFILKCIQRSEN-RPSAAQLLQDDFF
|| ..| . .|||| . |. ....  .|. .| ... .  |.  . ..      . ...|...| ..  . ||.|.||||. |.
DIWSLGCTVIEMATGKPPWHNYDHNHMAAMFKIGMGHKPHPPIPEHMSPISWISEECRDFLRHCFEHDPKKRPTANQLLQHPFI
Kinase 17822.AA STE 106-277 24 1.1e-40 141.43 In-house 119-359 (359) Show / Hide 
Range on Protein: 106-277
Range on HMM: 119-359/359
Sequence Identity: 24% (61 aa)

LSGGSLKKIKK---PR---------------LKIIKQWCKQILSG-LQYLHEQEPHPIIHRDIKCENIFVNTVNNEIRIGDLGLALTLKSD---------
..|||| .| |    .                ..|.  |.||| | |.|||..    |||||||. ||..      . . | |..  | ..         
MDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL------VKLCDFGVCGQLTDSMANIQSNNI

---------FTTSVLGTPEFMAPEIYEE-------KYGTAVDIYAFGMCLLEMATLQIPYRECTSA-AQVYKKVSQGLLP----------NSLQLIQN--
          .... ||| .||||. .        .|.| .||. .| ...|||| . |. . .   |  ..  ...  .          .. .| ..  
IDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLS

-------------------DSLKQFILKCIQRSEN-RPSAAQLLQ--DDFF
                   ...|.|| || |.  | ||.| |||.    |.
QNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 17822.AA Pkinase 122-277 27 2.6e-37 132.99 Pfam 110-293 (293) Show / Hide 
Range on Protein: 122-277
Range on HMM: 110-293/293
Sequence Identity: 27% (52 aa)

IKQWCKQILSGLQYLHEQEPHPIIHRDIKCENIFVNTVNNE---IRIGDLGLAL---TLKSDFTTSVLGTPEFMAPEI--YEEKYGTAVDIYAFGMCLLE
.| ...|||.||.|.|..    |||||.| |||...  ..    ..|.| |||    . ..  .|.. |||..||||.    ..||..||....|  | |
CKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYE

MATLQIPYREC-----TSAAQVYKKVSQGLLPNSLQLIQN-------------------DSLKQFILKCIQRSEN-RPSAAQLLQDDFF
|.. . |....      .  |..... .. |. . .   .                   ...|.|| .|...  . ||.|.|.||...|
MLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 17822.AA Ciliate-E2 106-277 21 4.2e-36 121.41 In-house 116-365 (365) Show / Hide 
Range on Protein: 106-277
Range on HMM: 116-365/365
Sequence Identity: 21% (60 aa)

LSGGSLKK-IK--------------KPRLKIIKQWCKQILS---------------GLQYLHEQEPHPIIHRDIKCENIFVNTVNNEIRIGDLGLALTLK
..||.|.. ||              .. .| ||.  ||||.               .|.|||.. .  ||||||| |||..      | | |.||.  ..
CQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNN--IIHRDIKPENILF------IKIIDFGLSKKYD

SD---------------------------------FTTSVLGTPEFMAPEIYEEK----------YGTAVDIYAFGMCLLEMATLQIPYRECTSAAQVYK
 |                                  . ...|||..|||||.. |          |....||...|..| || . . |.           
DDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF-----------

KVSQGLLPNSLQLIQN----------------------------DSLKQFILK----CIQRS-ENRPS-AAQLLQDDFF
          .| |..                            .. |..| |    ..|.  |.|.. . |.|.  .|
----------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 17822.AA Ciliate-E2-Unclassified 120-277 23 2.1e-35 120.28 In-house 138-352 (352) Show / Hide 
Range on Protein: 120-277
Range on HMM: 138-352/352
Sequence Identity: 23% (51 aa)

KIIK-----QWCKQILSGLQYLHEQEPHPIIHRDIKCENIFVNTVNN--EIRIGDLGLAL-----------------TLKSDFTTSVLGTPEFM----AP
. .|     ....|||.||.|||..    |||||||.|||...  ..  .|.| |.|..                   .|.. .... |||..|    ||
QQAKYKKAKFYFAQILQGLEYLHHKN--NIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAP

EIYEE-KYG----TAVDIYAFGMCLLEMATLQIPYR--ECTS-------------AAQVYKKVSQGLLPNSLQL------IQNDSLKQFIL----KCIQ-
|.... .|.     ..||...|..| || . . |.    |..               |.|..  |. . .. .       . ... | ||     |... 
EVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKK

RSENRPSAAQLLQDDFF
. ..|... |.|.  .|
NPNKRITFEQILNHPWF
S_TKc 17822.AA S_TKc 65-277 27 6.9e-35 123.15 SMART 1-231 (231) Show / Hide 
Range on Protein: 65-277
Range on HMM: 1-231/231
Sequence Identity: 27% (71 aa)

IKFNEELGFGAYKTVYKGYDNDSGCEIAW-------------------NVIKLQRLPQ--------QCLSG--GSLKK-IKKPR---------LKIIKQW
 .. ...| ||. .|||......| . |                    |..||    |         ...|  |.|.. ||| .            .. .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFY

CKQILSGLQYLHEQEPHPIIHRDIKCENIFVNTVNNEIRIGDLGLALTLKSDFTTSVLGTPEFMAPEIYEEKYGT-AVDIYAFGMCLLEMATLQIPYREC
..||...|.|.|.   | |||||.| |||....   .| |.| |||  |     |.. |||..||||.   .||. ..|....| .| ||.. . |..  
MYQICCALEYCHS---HGIIHRDLKPENILLDE---HIKICDFGLARQL-----TTFCGTPWYMAPEVL--GYGKCKCDWWSCGCILYEMLCGYPPFP--

TSAAQVYKKVSQGLLPNSLQLIQNDSLKQFILKCIQ-RSENRPSAAQLLQ-------DDFF
   ....||.              ...|.|| || |   |.||.| ..||       . .|
-QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 17822.AA TKL 107-273 22 1.1e-34 121.59 In-house 121-362 (364) Show / Hide 
Range on Protein: 107-273
Range on HMM: 121-362/364
Sequence Identity: 22% (54 aa)

SGGS-LKKIKKPRLKIIKQWCKQILSGLQYLHEQEP-----HPIIHRDIKCENIFVNTVNNE-------------IRIGDLGLALTLKSDF---------
.||| |  .    .  . .|...| .|..||| ..|      ||||||.| .||.|.  ..              . |.|.||. ... ..         
PGGSLLHYLH---WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTM

------------TTSVLGTPEFMAPEIYE-----------------EKYGTAVDIYAFGMCLLEMATLQIPYRECTSAAQV---------YKKVSQGLLP
            | .. ||| .||||. .                 ..| ...|.|.||..| |..| ..||..  .  ..         .. .. || |
MESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRP

NSL---------QLIQND--SLKQFILKCIQR-SENRPSAAQLLQ
            .   .   |.|. . .| .   |.|||. ..|.
PIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILK
Kinase 17822.AA ASK 122-277 35 2.4e-28 91.26 In-house 96-254 (254) Show / Hide 
Range on Protein: 122-277
Range on HMM: 96-254/254
Sequence Identity: 35% (58 aa)

IKQWCKQILSGLQYLHEQEPHPIIHRDIKCENIFVNTVNNEIRIGDLGLALTLK--SDFTTSVLGTPEFMAPEIYEE---KYGTAVDIYAFGMCLLEMAT
.. . |||| ||.||||..   |.||||| .|. |||    ..| | | .  |      | .  ||  .||||. ..    || . ||..||  ..||||
MNFYTKQILEGLKYLHENQ---IVHRDIKGDNVLVNTYSGVVKISDFGTCKRLAGINPCTETFTGTLQYMAPEVIDQGQRGYGKPADIWSFGCTMVEMAT

LQIPYRECTSAAQVYKKVSQGLLPNSLQLIQNDSLKQFILKCIQRS-ENRPSAAQLLQDDFF
 . |. |  ..     ||        .     .  |.|||.| . . ..|.||..||||.| 
GKPPFHELGEPQAAMFKVGMYKKHPEIPEELSAECKNFILRCFEPDPCKRASAQDLLQDPFL
Kinase 17822.AA NEK 120-277 29 3.5e-28 96.59 In-house 114-286 (286) Show / Hide 
Range on Protein: 120-277
Range on HMM: 114-286/286
Sequence Identity: 29% (53 aa)

KIIKQWCKQILSGLQYLHEQEPH---PIIHRDIKCENIFVNTVNNE---IRIGDLGLALTLKSD--FTTS-VLGTPEFMAPEIY-EEKYGTAVDIYAFGM
..|  |. |....|.|.|..       |.|||||. ||| .  ||.   ..|||.|..  |...  . .. . ||| .|.||.  ...|.  .|| ..| 
EQIWDWFIQMCLALKYMHDRK-GPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNKPYNNKSDIWSLGC

CLLEMATLQI--PYRECT--SAAQVYKKVSQGLLPNSLQLIQND-----SLKQFILKCIQRS-ENRPSAAQLLQDDFF
.| ||.||.   |  | .  .  . |.|. .|      . |.        |...| ...|.. |.|||. |.|.. | 
VLYEMCTLKPKHPF-EAWDMNMPSLYMKIMKG---PQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase 17822.AA CAMK 123-277 18 1.1e-27 85.75 In-house 182-425 (425) Show / Hide 
Range on Protein: 123-277
Range on HMM: 182-425/425
Sequence Identity: 18% (46 aa)

KQWCKQILSGLQYLHEQEPHPIIHRDIKCENIFVNTVN----------------NEIRIGDLGLALTLKS-------------------------DFTTS
... .||.|...|.|..  . |.|||.|.||| ... |                | | | | |.|  ...                         .  . 
RRYFRQICSAVHYCHSH--N-IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKT

VLGTPEFMA-PEIYEEK---------------YGTAVDIYAFGMCLLEMATLQIPYRECT------------SAAQVYKKVSQGLLPNSLQLIQN-----
. ||||.|| ||. . |               || ..|. . |  |  | .   |... .            .  . ..|. .|        . .     
FCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNY

-----------------DSLKQFILKCIQR-SENRPSAAQLLQDDFF
                 .. |..| |. |.  |.|....| |.. ..
GPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 17822.AA ULK 120-277 24 1.2e-24 83.06 In-house 130-329 (329) Show / Hide 
Range on Protein: 120-277
Range on HMM: 130-329/329
Sequence Identity: 24% (49 aa)

KIIKQWCKQILSGLQYLHEQEPHPIIHRDIKCENIFVNT-V----------NNEIRIGDLGLALTLKSD-----FTTSVL------GTPEFMAPEIYEEK
....| .||||.|...||.   | ||||||| .|| ..  .          |. . |.| |.| .. .|      ... .      ||| .|||.| ...
QEAIQFFKQILNGFKELHK---HNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQ

-----YGTA-VDIYAFGMCLLEMATLQIPYRECTSAAQV----YKKVSQGLLPN----SLQLIQN---------DSLKQFILKCIQRSEN-RPSAAQLLQ
     |... .||. .|. . || . . |....    |.    .| . ... ..    . .|  .         . .|..| ...|. |. | |  .|..
GEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDLIRRMLQYDEKDRISWEELFN

DDFF
  .|
HPWF
Kinase 17822.AA WNK 65-104 42 8.4e-24 73.68 In-house 1-40 (261) Show / Hide 
Range on Protein: 65-104
Range on HMM: 1-40/261
Sequence Identity: 42% (17 aa)

IKFNEELGFGAYKTVYKGYDNDSGCEIAWNVIKLQRLPQQ
.||.||.|.|..||||.|.|.....|.||.....|.|...
MKFDEEVGRGSFKTVYRGLDTETWVEVAWCELQDQKLSKN
Kinase 17822.AA TyrKc 65-276 21 2.4e-13 -7.02 SMART 1-280 (280) Show / Hide 
Range on Protein: 65-276
Range on HMM: 1-280/280
Sequence Identity: 21% (62 aa)

IKFNEELGFGAYKTVYKGYDNDSGCEIAWNVIK-------------LQRL------------------------PQQCL-----SGGSLKK-IKKPR---
|.....|| ||. .||||  .    . |  ..|             . .|                        .. ..     ..|.||. ..|.|   
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKL

-LKIIKQWCKQILSGLQYLHEQEPHPIIHRDIKCENIFVNTVNNEIRIGDLGLALTLKSD-------FTTSVLG--TPEF------MAPEIYEEK-YGTA
 .|   ..| || .| .|||..   ..||||. . |. |.  .  ..|.| ||.  ...|        . .. .     .      ||||   .. . |.
CMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTK

VDIYAFGMCLLEMATL-QIPYREC----TSAAQVYKKVSQGLLPNSLQL-------IQNDSLKQFILKCIQR-SENRPSAAQLLQDDF
 |...|| |. |. |. | || .      |...|...| ||  .   .        .  | . | ...| ..  |.||. ...  ..|
SDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-HECF
Kinase 17822.AA Pkinase_Tyr 124-237 32 4.7e-09 31.28 Pfam 115-232 (270) Show / Hide 
Range on Protein: 124-237
Range on HMM: 115-232/270
Sequence Identity: 32% (40 aa)

QWCKQILSGLQYLHEQEPHPIIHRDIKCENIFVNTVNNEIRIGDLGLALTL-KSDFT-TSVLGTPEF----MAPE-IYEEKYGTAVDIYAFGMCLLEMAT
|.| || .|..||...    .||||. . |. |.  || ..|.| ||| .. . |   ..  |.. .    |||| | . |. |. |...|| .. |. |
QMCWQIAKGMEYLESKN---CIHRDLAARNCLVTE-NNVVKICDFGLARDIYNDDYYYRKRGGGK-LPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFT

L-QIP-YRECTSAAQVYKKV-SQG
. ..| | .. | ..||...  .|
YGEQPTYPGM-SNEEVYEYIYEDG
Kinase 17822.AA Ciliate-E2 65-104 27 0.000168 11.35 In-house 1-38 (365) Show / Hide 
Range on Protein: 65-104
Range on HMM: 1-38/365
Sequence Identity: 27% (11 aa)

IKFNEELGFGAYKTVYKGYDNDSGCEIAWNVIKLQRLPQQ
.||.. .|.|.. .|||. .   ....| ..|. | . |.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQ-QR
Kinase 17822.AA STE 65-92 23 0.00225 7.92 In-house 1-43 (359) Show / Hide 
Range on Protein: 65-92
Range on HMM: 1-43/359
Sequence Identity: 23% (10 aa)

IKFNEELGFGAYKTVYKGYDND---------------SGCEIA
 .. |..| ||. ||||.....               .|. .|
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMA
Kinase 17822.AA ULK 65-88 33 0.007163 5.96 In-house 1-24 (329) Show / Hide 
Range on Protein: 65-88
Range on HMM: 1-24/329
Sequence Identity: 33% (8 aa)

IKFNEELGFGAYKTVYKGYDNDSG
.  |..|| |.. .||||......
YCLNHCLGKGSFGKVYKGRNKKTK
Kinase 17822.AA ASK 71-92 45 0.033615 2.9 In-house 2-23 (254) Show / Hide 
Range on Protein: 71-92
Range on HMM: 2-23/254
Sequence Identity: 45% (10 aa)

LGFGAYKTVYKGYDNDSGCEIA
|| |.| .|| | | .    ||
LGKGTYGIVYAGRDMHTQVRIA
Kinase 17822.AA Pkinase 65-92 25 0.06575 7.83 Pfam 1-28 (293) Show / Hide 
Range on Protein: 65-92
Range on HMM: 1-28/293
Sequence Identity: 25% (7 aa)

IKFNEELGFGAYKTVYKGYDNDSGCEIA
... . .| |.. .|||... ..|.. |
YHIGRKIGSGSFGCVYKCHHKGTGKIVA
Kinase 17822.AA STE11 71-92 45 0.21324 1.17 In-house 7-28 (303) Show / Hide 
Range on Protein: 71-92
Range on HMM: 7-28/303
Sequence Identity: 45% (10 aa)

LGFGAYKTVYKGYDNDSGCEIA
.| ||. ||||... | | ..|
IGKGAFGTVYKCMNVDTGELMA
Kinase 17822.AA Pkinase_Tyr 65-83 52 0.834438 3.35 Pfam 1-19 (270) Show / Hide 
Range on Protein: 65-83
Range on HMM: 1-19/270
Sequence Identity: 52% (10 aa)

IKFNEELGFGAYKTVYKGY
|.|...|| ||. .||||.
ITFGKKLGEGAFGEVYKGT