Gene 9457 (Tetrahymena)

9457

Species: Tetrahymena
Alias: TTHERM_00128930, PreTt09457, 9457, 535, 9.m00478, 3699.m00186
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: ULK
Subfamily: ULK

Sequence

Name Sequence Type Origin Length Description Download
9457.AA Protein None 597 None Fasta, JSON
9457.kin_dom Protein Kinase Domain None 255 None Fasta, JSON
9457.NA RNA None 1794 None Fasta, JSON

Protein domain

Protein domains of 9457.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 9457.AA ULK 12-266 33 9.90000000001e-112 377.5 In-house 1-329 (329) Show / Hide 
Range on Protein: 12-266
Range on HMM: 1-329/329
Sequence Identity: 33% (109 aa)

IVLNKPIGKGNQATVYESYRKDN----LQIVAAKVFDLTQNGQTNQARN-------LQRQVKILTTLK--------HPYILECFDIKQTQ--KNQYFFLE
..||. .|||  ..||. . |..     ..||.|. |. .  | |. ..       |.. .||. .||        ||.| . .|...|.  .| |...|
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

YCDGGDLEKYLK----------EKQFITESECLDLFKQIVSAFQMLEKKNIVHRDLKPANILLKNGQ-------------LKIADFGFAKEIQDD-----
||.|||||.|.|          ||....|.|..  ||||...|..| |.||.|||.||.|||..|||             |||||||||| ...|     
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

VQNTIV------GSPIFMCPQALDGTG---HYDLKKGDVWSAGVCLYLMLYGIYPFYASNVQNLI-----QTLKQ----------QQLVFRD--DLYKRS
.  | |      |.|..|.|| | | |   .|. .| |.|| |. .| |||| .||||.  . ..     . ...          |.| |..  . ...|
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQIS

DAVKDLLSHMLEKEESKRYTWDQVASHKCL
. .|||.. ||...|..| .|... .|...
PECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 9457.AA ULK 12-266 33 2.4e-111 376.21 In-house 1-324 (324) Show / Hide 
Range on Protein: 12-266
Range on HMM: 1-324/324
Sequence Identity: 33% (108 aa)

IVLNKPIGKGNQA-TVYESYRKDN---LQIVAAKVFDLT-QNGQTNQAR------NLQRQVKILTTLK---HPY--ILECFDIKQTQ--KNQYFFLEYCD
..||. .|||  . .||. . |..    |.||.|. |.  .| . |..       .|.. ..|. .||   ||.  | . .|...|.  .| |...|||.
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

GGDLEKYLK---------EKQFITESECLDLFKQIVSAFQMLEKKNIVHRDLKPANILLKNGQ-------------LKIADFGFAKEIQD-----DVQNT
|||||.|.|         ||....|.|..  ||||...|..| |.||.|||.||.|||..|||             |||||||||| ...     ..  |
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

IV------GSPIFMCPQALDGTG---HYDLKKGDVWSAGVCLYLMLYGIYPFYASNVQNLIQ--------------TLKQQQLVFRD--DLYKRSDAVKD
.|      |.|..|.|| | | |   .|. .| |.|| |. .| |||| |||...  .....              . |.|.. |..  . .|.|. .||
CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKD

LLSHMLEKEESKRYTWDQVASHKCL
|.. ||...|..| .|... .|...
LIRRMLQYDEKDRISWEEIFNHPWF
Kinase 9457.AA Ciliate-E2c 12-266 32 1.6e-103 350.24 In-house 1-310 (310) Show / Hide 
Range on Protein: 12-266
Range on HMM: 1-310/310
Sequence Identity: 32% (100 aa)

IVLNKPIGKGNQATVYESYRKD------NL---------QIVAAKVFDLTQNGQTNQARNLQRQVKILTTLKHPYILECFDIKQTQKNQYFFLEYCDGGD
|  |.. |.|....||  |.        |           . ..|..|. .. .... . . |.. .. ...||.|... | ||| |. |...||| ||.
IDRNNILGSGSYGKVYKAYYCEDYQNEINNVQMNQLFAIKMTCLKNKDIHMINEKDIKESIIREINMMKHMNHPHIIKFYDAKQTDKHIYLIMEYCNGGT

LEKYLKEKQFITESECLDLFKQIVSAFQMLEKK-NIVHRDLKPANILLKNGQLKIADFGFAKEIQDDVQN------TIVGSPIFMCPQALDGTGHYDLKK
||.|...|  ..| .||..|.||.|||. | |. || |||.||.|||..||..|||||||.|..|||  .      |..|.|..| ||.| | . |...|
LEQYIYHKPKPNEKQCLYYFSQIISAFKYLHKEKNIFHRDIKPENILIHNGMIKIADFGFSKICQDDNIQNTQGFNTCCGTPMYMAPQILEG-KNYYTEK

GDVWSAGVCLYLMLYGIYPFY------------------ASNVQNLIQTLK---------------QQQLVFRDD-LYKRSDAVKDLLSHMLEKEESKRY
 |.||.||.|| ||.  .|..                  .. .. |.|  .               .|.. | .. . ..|  ||.|.  ||...|.|| 
SDIWSLGVTLYYMLCYKLPWESIQEYDSHNICNHCYPWWQNTMKHLKQHIWEYFNPQASAAGVSPITQNIHFPENYEQNISQEVKQLIHKMLQVDEEKRI

TWDQVASHKCL
 ||... | |.
DWDEIFNHECI
Kinase 9457.AA Ciliate-E2 12-266 26 1.9e-80 273.55 In-house 1-365 (365) Show / Hide 
Range on Protein: 12-266
Range on HMM: 1-365/365
Sequence Identity: 26% (99 aa)

IVLNKPIGKGNQA-----TVYESYR------------------KDNLQIVAAKVFDLTQNGQTNQARNLQRQVK----------ILTTLKHPYILECFDI
. ..| ||.||..     .|..  .                  |.. .|.| |..   |  |..|  .. |...          || .|.||.|..... 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

KQ--TQKNQYFFLEYCDGGDLEKYLKEKQF-----------ITESECLDLFKQIVS---------------AFQMLEKKN-IVHRDLKPANILLKNGQLK
 |  ...| |. .|||.||||..|.|...            .|| |.....|||..               |.. | .|| |.|||.|| |||.    .|
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----IK

IADFGFAKEIQDD---------------------------------VQNTIVGSPIFMCPQALDGTG-------HYDLKKGDVWSAGVCLYLMLYGIYPF
|.|||..|...||                                 ..|||.|.| .|.|. | | .       ..  .| |.||.||.|| ||.| .||
IIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF

YASNVQNLIQTLKQQQLVFRDDLY---------------KRSDAVKDLLSH----MLEKEESKRYT-WDQVASHKCL
        .|  ||... |.   .               | |. .|||..     ||.|...||.| |.|.  |. .
--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 9457.AA S_TKc 12-266 29 4.2e-75 256.74 SMART 1-231 (231) Show / Hide 
Range on Protein: 12-266
Range on HMM: 1-231/231
Sequence Identity: 29% (80 aa)

IVLNKPIGKGNQATVYESYRKDNLQIVAAKVFDLTQNGQTNQARNLQRQVKILTTLKHPYILECFDIKQTQKNQYFFLEYCDG--GDLEKYLKEKQF---
  . ..||||  ..||  . |.  .||| |. .          ....| ..||   .||.|  ..|. |. .. |...|||||  ||| .|.|...    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---ITESECLDLFKQIVSAFQMLEKKNIVHRDLKPANILLKNGQLKIADFGFAKEIQDDVQNTIVGSPIFMCPQALDGTGHYDLKKGDVWSAGVCLYLML
   ..| ..  ...||..| . . ...|.||||||.|||| . ..||.|||.|...     .|..|.| .| |  |    .|. .| |.|| |..|| ||
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL-----TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEML

YGIYPFYASNVQNLIQTLKQQQLVFRDDLYKRSDAVKDLLSHMLEKEESKRYTWDQVAS-------HKCL
.|  ||.  ..| ... ..             |. .||.....|.|. .||.|  ..         |  .
CGYPPFP--QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 9457.AA Ciliate-E2-Unclassified 12-266 25 2.3e-72 246.73 In-house 1-352 (352) Show / Hide 
Range on Protein: 12-266
Range on HMM: 1-352/352
Sequence Identity: 25% (92 aa)

IVLNKPIGKGNQATVYESYRKDNLQIV-----AAKVFDLTQNGQTN-----------QARNLQRQVK--------ILTTLKHPYILECFDIKQTQKNQYF
  ..| ||.|....||. ..|..   .     . |. .  |. . |           . ..   ...        ||  ..||.|. .|...|...| |.
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKK-YHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI

FLEYCDGGDLEKYLKEK-----------------QFITESECL-----DLFKQIVSAFQMLEKKN-IVHRDLKPANILLKNG----QLKIADFGFAKEIQ
 .|||.||||..|.|..                 . .|| ...     ..|.||..... | .|| |.|||.|| |||..|.    ..||.|||..|..|
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ

-----------------DDVQNTIVGSPIFM----CPQALDGTGHYDL--KKGDVWSAGVCLYLMLYGIYPFYASNVQN----------------LIQTL
                 .. ..|..|.|..|     |  |.| ....   .| |.|| ||.|| ||.| ||||. |                   |.|  
QNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNI

KQQQLVFRDDL-----YKRSDAVKDLLS----HMLEKEESKRYTWDQVASHKCL
||... |.        .. |. .||...     ||.|  .||.|..|.  |  .
KQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 9457.AA CAMK 17-266 22 1e-69 223.6 In-house 1-425 (425) Show / Hide 
Range on Protein: 17-266
Range on HMM: 1-425/425
Sequence Identity: 22% (94 aa)

PIGKGNQATVYESYRKDNL------------QIVAAKVFDLTQNG-------------------------QTNQARNLQRQVKILTT-------LKHPYI
 .|.|. ..|.. ..| .             | ||.|. | ..                           . .  .|..| ..|. .       |.|| |
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

LECFDIKQ------------TQKN--------QYFFL---EYCDGG----DLEKYLKEK---------------QFITESECLDLFKQIVSAFQMLEKKN
. .... .            | ..         |...   |||.||    ||  |..|.                 .||.|.  .|.||.|| . . ..|
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IVHRDLKPANILL-KN-----------------GQLKIADFGFAKEIQ-------------------------DDVQNTIVGSPIFMC-PQALDGTG---
|||||||| |||| .|                 ...||.|||||....                         ..  .| .|.| .|. |  | | |   
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

---------HYDLKKGDVWSAGVCLYLMLYGIYPFYAS-------------NVQNLIQTLKQQQLVFRDDLYK-------------RSDA--------VK
          |. .| |.||.|| || || | .|||..             | ..| .  .. .  | ..  .              ||         .|
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

DLLSHMLEKEESKRYTWDQVASHKCL
||...||... .||.| .|. .|. .
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 9457.AA CAMKL 11-266 28 5.8e-66 209.45 In-house 1-297 (297) Show / Hide 
Range on Protein: 11-266
Range on HMM: 1-297/297
Sequence Identity: 28% (85 aa)

YIVLNKPIGKGNQATVYESYR-KDNLQIVAAKVFDLTQNG-QTNQARN-----------LQRQVKILTTLK---HPYILECFDIKQTQKN------QYFF
|...   .|||. ..|      . . . || |. |       ..  .|           ..| ..|.  |.   || |   ... .|...       | .
YRIGK-TLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLV

LEYCDGGD--LEKYLKEKQF----ITESECLDLFKQIVSAFQMLEKKNIVHRDLKPANILLK-NG--QLKIADFGFAKEIQ------DDVQNTIVGSPIF
.|||.||.  |  |....      ..|.|.  .|.||||| . . ...|||||.|| ||||  ||  ..||.||||. ...      ..  .|  ||| .
MEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPY

MCPQALDG-TGHYDLKKGDVWSAGVCLYLMLYGIYPFYASNV------QNLIQTLKQQQLVFRD-DLYKRSDAVKDLLSHMLEKEESKRYTWDQVASHKC
|.|  . |   .|| .| |.||.|| || |..| .|| . ..       .    .|. .. ...   |. |  ..||...||..  .||.| .|. .|. 
MAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPW

L
.
M
Kinase 9457.AA Pkinase 12-266 27 3e-56 198.0 Pfam 1-293 (293) Show / Hide 
Range on Protein: 12-266
Range on HMM: 1-293/293
Sequence Identity: 27% (81 aa)

IVLNKPIGKGNQATVYESYRKDNLQIVAAKVFDLTQNGQTNQARNLQ-RQVKILTTLKHPYILECFDIKQTQKNQYFFLEYCDGG----DLEKYLK--EK
... ..||.|. ..||. ..|.. .||| |....  .    . ...  . ..|.  |.||.|....|. .. .. |. .|||.||    ||  |..  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

QFI--TESECLDLFKQIVSAFQMLEKKNIVHRDLKPANILLK-NGQL----KIADFGFAK---EIQDDVQNTIVGSPIFMCPQALDGTGHYDLKKGDVWS
  .  .| || . ..||... . . ...|.||||||.|||.. ||..    ||.|||.||   .  .   .|..|.| .| |  .  .| |. .| |.||
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR-GGQYYGPKVDMWS

AGVCLYLMLYGIYPFYAS----NVQNLIQTLKQQQL--VFRDDLYKRS-------------------DAVKDLLSHMLEKEESKRYTWDQVASHKCL
.|. || || |  ||. .    |  . .| ...     . .|  ...|                   .. ||... .|.|  .||.|..|.  |. .
CGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 9457.AA Ciliate-E2a 11-266 30 3.4e-49 142.98 In-house 1-275 (275) Show / Hide 
Range on Protein: 11-266
Range on HMM: 1-275/275
Sequence Identity: 30% (85 aa)

YIVLNKPIGKGNQATVYESYRKDNLQIVAAKVFDLTQNGQTNQARNLQRQVKILTTLKHPYILECFDIKQTQKNQYFFLEYCDGGDLEKYLKEKQFITES
| .. | ||||| . ||   .|.. .  |.|.|.   . |... ..... ..|. .|.|| |.  ... .. .| |. .|||.||.|....|... ..| 
YKFI-KKIGKGNFGSVYLAQHKQTGKQFAMKKFIKKMYQQKKGKEYFMNEINIMRQLDHPNIIKLYEVYEDENNYYLVMEYCEGGELYDKIKQCKRFFEE

--ECLDLFKQIVS-AFQMLEKKNIVHRDLKPANILLK----NG----QLKIADFGFAKEIQDDVQN---TIVGSPIFMC------PQALDGTGHYDLKKG
  |  |. .|. . ... . ..||.|||||| |||.|    |.    ..||.|||.|. |..| ..   ...|.| ..       .. | ..  || .| 
IQEICDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKIIDFGLATFIDKDEKKYMFQKCGTPGYVAPEVLNNKEVLKHKQ-YD-TKC

DVWSAGVCLYLMLYGIYPFYASNVQNLIQTLKQQQLVFRDDL-YKR-SDAVKDLLSHMLEKEESKRYTWDQVASHKCL
|.||.|| .|..|.|  ||.. ...  .|  |. .. | .   ..  |.. |||.. ||||  .||.|  |   |.  
DMWSCGVIFYILLCGKPPFKGKTYNEILQQNKKCKIDFNCPECWEKCSKECKDLMKKMLEKDPKKRITAQQALNHPWF
Kinase 9457.AA MARK 11-209 37 1.2e-48 157.2 In-house 1-206 (262) Show / Hide 
Range on Protein: 11-209
Range on HMM: 1-206/262
Sequence Identity: 37% (78 aa)

YIVLNKPIGKGNQATVYESYRKDNLQIVAAKVFDLTQNGQTNQARNLQRQVKILTTLKHPYILECFDIKQ--TQKN-QYFFLEYCDGGDLEKYLKEK--Q
| .| | ||.|. |.|.    |   . || |. . ..    .. .|..| ..|.  |.||.| ..|.. .  | ..  |. .||. ||.|  |.|..   
YKML-KTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNG

FITESECLDLFKQIVSAFQMLEKKNIVHRDLKPANILL-KNG--QLKIADFGFAKEIQDDV-QNTIVGSPIFMCPQALDGTGHYDLKKGDVWSAGVCLYL
 ..|.|.  .|.||||| . . .|||||||.|| |||. .||  . ||.||||. .|. .   ||  |.| .|.|. . .   || .| |.|| || || 
RLHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQKLNTFCGTPPYMAPEIFLKKP-YDGPKVDIWSLGVVLYF

MLYGIYPF
|. | .||
MVCGYFPF
Kinase 9457.AA CAMK-Unique 12-266 18 6.6e-47 152.77 In-house 1-363 (363) Show / Hide 
Range on Protein: 12-266
Range on HMM: 1-363/363
Sequence Identity: 18% (67 aa)

IVLNKPIGKGNQATVYESYRKDNLQIVAAKVFDLTQNGQTNQARN-----------------LQRQVKILTTLKHPYILECFDI----KQTQK-------
. ....||.||   |||   . .  . | |.. .   |   |  .                 | | . |. ...|| |.. .|.    ... |       
YKMHRIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLI

--------NQYFFLEYCDGGDLEKYLKE--------------------KQFITE--SECLDLFKQIVSAFQMLEKKNIVHRDLKPANILLKNG-------
        . | ..|||.|||| ... .                    ..  .|  .. . .. ...||   . ...|||||||. ||....        
IKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHH

----------QLKIADFGFAKEIQDDVQN----TIVGSPIFMCP--------------QALDGTGHYDLKKG---DVWSAGVCLYLMLYGIYPFYASNVQ
           .|..||| .....    .    |..|.|..| |              . ... . || . .   | || || .|.|| |. ||....  
RDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQC-YDQQCSPASDIWSLGVIMYYMLCGCPPFDCECED

--------NLIQTLKQQQL-VFRDDLYKR----SDAVKDLLSHMLEKEESKRYTWDQVASHKCL
        ....  .. ..  |. . . .    |.. ||..   .. . ..| .  .  .|  .
RDYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI
Kinase 9457.AA Pkinase_Tyr 12-162 30 3.3e-15 52.14 Pfam 1-164 (270) Show / Hide 
Range on Protein: 12-162
Range on HMM: 1-164/270
Sequence Identity: 30% (51 aa)

IVLNKPIGKGNQATVYESYRK----DNLQIVAAKVFDLTQNGQTNQ--ARNLQRQVKILTTL-KHPYILECFDIKQ-TQKN--QYFFLEYCDGGDLEKYL
|...| .|.|.  .||. . |    .. . || |.    ..    |   . . | .||...| .|| |. .  .    ..    |  .||. .||| .||
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML--KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

KE----KQFITESECLDLFKQIVSAFQMLEKKNIVHRDLKPANILLK-NGQLKIADFGFAKEIQDD
..    || .| .. |.   || .. . || ||..||||   |.|.. |.. ||.||| |. |..|
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYND
Kinase 9457.AA TyrKc 12-266 24 5.2e-15 20.03 SMART 1-280 (280) Show / Hide 
Range on Protein: 12-266
Range on HMM: 1-280/280
Sequence Identity: 24% (71 aa)

IVLNKPIGKGNQATVYESYRKDNLQIVAAKVFDLTQNGQTNQARNLQRQVKILTTL--KHPYILECFDIKQTQ-------KNQYFFLEYCDGGDLEKYLK
|.|.| .| |.  .||.   |   . || |.            . . |  .|.. |  .|| |. .. .  .|       .  .  .||...||| .||.
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

EKQ-FITESECLDLFKQIVSAFQMLEKKNIVHRDLKPANILLKNGQ-LKIADFGFAKEIQDD-------VQNTI----VG---SPIF-MCPQALDGTGHY
...  .. .. |.   || .  . |..||..||||   |.|.....  ||.||| ...| ||          .      |    ||  | | ..  .| .
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-NYGKF

DLKKGDVWSAGVCLY-LMLYGIYPFYA-----SNVQNLIQTLKQQQLVFRDDLYK------RSDAVKDLLSHMLEKEESKRYTWDQVASHKCL
   | |||| |||.. .. ||  | .       . | .|. .||     . . .        .|.. .. .   . . ..| |  ..  |.|.
T-TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase 9457.AA MARK 236-266 19 0.013795 4.47 In-house 232-262 (262) Show / Hide 
Range on Protein: 236-266
Range on HMM: 232-262/262
Sequence Identity: 19% (6 aa)

SDAVKDLLSHMLEKEESKRYTWDQVASHKCL
|.  ..|.. .|    ..| | ... .|. .
SKECRNLIQRLLTVNPEERPTIEEIMKHPWM