Gene 21109 (Tetrahymena)
21109
Sequence
Protein domains of 21109.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 21109.AA | ULK | 48-311 | 37 | 1.4e-124 | 420.21 | In-house | 1-324 (324) | Show / Hide |
Range on Protein: 48-311 Range on HMM: 1-324/324 Sequence Identity: 37% (123 aa) YITKQNLGKGAFG-SVFIAYRLTKEGKKNGKFAAKVIQLTTLND--KE------IIQLTREIEILKTIR---HDN--IVKMEHVTRTK--NNLYLFLEYI |. .. ||||.|| |. .. ... .| ..|.|.|.. .|. .| . .| .||.|.|.. | | |||. ....|. ||.|...|| YCLNHCLGKGSFGVKVYKGRNKKTNT-QNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYC KDGDLSKYLE---------NKRRLSQEETVFFFRQIVNGFKELYKRNIIHRDIKPENILLEKKENHK---------RLLISDFGFARVVNQDQMNKQIEQ .|||..|.. .|.|||..|.. ||.||.||||||.|.|||||||||.|||. .. .. .| |.|||||..|. ..|..|. | NGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQ TPV------GSLKYMAPQILG----IINFS-CKCDVWSLGVMIYELLYGYPP---WMDDTYQ----RLLNR-------ILSQPLTFP---ENVQIIPELK | | |. ||||||| .... |||.||||...||.|||..| | ... .|.| | ||. || ....| ||.| TCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECK ELLRRMMTIDEEQRISWDEIFLHPLM .|.|||...||..||||.||| ||.. DLIRRMLQYDEKDRISWEEIFNHPWF |
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| Kinase | 21109.AA | ULK | 48-311 | 38 | 3.9e-124 | 418.69 | In-house | 1-329 (329) | Show / Hide |
Range on Protein: 48-311 Range on HMM: 1-329/329 Sequence Identity: 38% (126 aa) YITKQNLGKGAFGSVFIAYRLTKEGK-KNGKFAAKVIQLTTLNDKE--------IIQLTREIEILKTIR----HDN----IVKMEHVTRTK--NNLYLFL |. .. ||||.|| |. .. .. . .| |.|.|.|.. ..| |. . .|..||.|.|.. | | |||. ....|. ||.|... YCLNHCLGKGSFGKVYKGRNKKTK-DYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIM EYIKDGDLSKYLE----------NKRRLSQEETVFFFRQIVNGFKELYKRNIIHRDIKPENILLEKKENHK---------RLLISDFGFARVVNQDQMNK || .|||..|.. .|.|||..|.. ||.||.||||||.|.|||||||||.|||. .. .. .| |.|||||..|. |.|.. EYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQ QIEQTPV------GSLKYMAPQILG----IINFS-CKCDVWSLGVMIYELLYGYPP---WMDDTYQ-----RLLNR-------ILSQPLTFP---ENVQI |...| | |. ||||||| .... |||.||||...||.|||.|| | ... .|.| | .||| || ...|| QMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQI IPELKELLRRMMTIDEEQRISWDEIFLHPLM ||.|.|.|||...||..||||.|.| ||.. SPECKDLIRRMLQYDEKDRISWEELFNHPWF |
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| Kinase | 21109.AA | S_TKc | 48-311 | 30 | 2.4e-83 | 284.11 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 48-311
Range on HMM: 1-231/231
Sequence Identity: 30% (85 aa)
YITKQNLGKGAFGSVFIAYRLTKEGKKNGKFAAKVIQLTTLNDKEIIQLTREIEILKTIRHDNIVKMEHVTRTKNNLYLFLEYIKD--GDLSKYLENKRR
| . .||||||.|. .. . ..| |.| ... |||.||| .|.||||. | .. ..||...||. ||| .|.....|
YEILRKIGKGAFGKVYKCRHKK----TGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGR
------LSQEETVFFFRQIVNGFKELYKRNIIHRDIKPENILLEKKENHKRLLISDFGFARVVNQDQMNKQIEQTPVGSLKYMAPQILGIINFSC-KCDV
.. .. |...||... . . ...|||||.||||||| . .. |.|||.||.. | .|.. |||| .| ... |||.
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL----------TTFCGTPWYMAPEVL---GYGKCKCDW
WSLGVMIYELLYGYPPWMDDTYQRLLNRILSQPLTFPENVQIIPELKELLRRMMTIDEEQRISWDEIFL-------HPLM
||.|...||.|.||||. ..|.....|. ||.|...|.... | |.|.. |.. || .
WSCGCILYEMLCGYPPFP--QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | 21109.AA | CAMK | 53-311 | 22 | 1.1e-80 | 259.53 | In-house | 1-425 (425) | Show / Hide |
Range on Protein: 53-311
Range on HMM: 1-425/425
Sequence Identity: 22% (95 aa)
NLGKGAFGSVFIAYRLTKEGKKN--------GKFAAKVIQLTTLN--------------------------DKEIIQLTREIEILKT-------IRHDNI
||.|.|| |. ... ||.. |.|.|.| . | .| .. |||||.|. ..| ||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI
VKMEHVTR------------TKNN--------LYLFL---EYIKDG----DLSKYLENK---------------RRLSQEETVFFFRQIVNGFKELYKRN
.|. .| | .. .|... ||. | || |. . .|.. .|. ..||||. . . . ..|
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN
IIHRDIKPENILLEKKENHK--------------RLLISDFGFARVVNQDQMNK--------------------QIEQTPVGSLKYMA-PQILGI-----
|.|||.||||||| ...... . |.|||||....... |. | .|..|.. ||| | .|
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN
--------INF-SCKCDVWSLGVMIYELLYGYPPWMDD-------------TYQRLLNRILSQPLT-FPENVQIIP---------------------ELK
. . |||.||.||. | .| ||||. .| ....|. .|.. . |. . .|. | |
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK
ELLRRMMTIDEEQRISWDEIFLHPLM
|.|.|.. | |.|.. ... || |
DLIRKMLQVDPEKRMTIEQCLNHPWM
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| Kinase | 21109.AA | Ciliate-E2 | 48-311 | 23 | 7.7e-79 | 268.24 | In-house | 1-365 (365) | Show / Hide |
Range on Protein: 48-311
Range on HMM: 1-365/365
Sequence Identity: 23% (91 aa)
YITKQNLGKGAFGSVFIAYRLTKEGKKN--------------GKFAAKVIQLTTLNDKEIIQLTREIEILKTIR----------------HDNIVKMEHV
|. . .|.|.||||. . . . ... |...| . . ... ..|.|. .|| |...|. |.||.|| .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC
TR--TKNNLYLFLEYIKDGDLSKYLENKR-----------RLSQEETVFFFRQIVN---------------GFKELYKRN-IIHRDIKPENILLEKKENH
..||.|| .||.. ||| .|..|.. ... .| ....||.. ....| ..| ||||||||||||.
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------
KRLLISDFGFARVVNQD-------QMNKQIEQTP----------------------VGSLKYMAPQILGIIN---------FSCKCDVWSLGVMIYELLY
. |.|||... ...| |..| . . .|.. ||||.||. . . |||.|||||..||.|.
--IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLF
GYPPWMDDTYQRLLNRILSQPLTFP----------------ENVQIIPELKELLRR----MMTIDEEQRIS-WDEIFLHPLM
|.||. .. |. ... || .. .. .| | |... |. |.|.||. |..|. || .
GKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
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| Kinase | 21109.AA | AGC | 48-311 | 21 | 2.7e-78 | 201.18 | In-house | 1-395 (395) | Show / Hide |
Range on Protein: 48-311 Range on HMM: 1-395/395 Sequence Identity: 21% (86 aa) YITKQNLGKGAFGSVFIAYRLTKE-GKKNGKF-AAKVIQLTT---LNDK-EIIQLTRE------------IEILKTIR----------HDNIVK-MEHVT . . .|||.|| |. . . ... .| .||. | ||.. . ...| .. . .| .||.... |..||| . . FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF RTKNN--LYLFLEYIK----------DGDLSKYLE---NKRRLSQEETVFFFRQ-------IVNGFKELYK-RNIIHRD-IKPENILLEKKENHKRLLIS .|.. ||. .||.. ...| .| ...|.. |.. |.. . || .. | . ..||||| .||||||| .. . .. QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDED---GHIKLT DFGFARVVNQDQ----------------------------------------------MNK--QIEQTPVG--SLKYMAPQILGIINFSCKCDVWS--LG |||.. ....|. . | . .| .| . |||| || . || || || DFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTR-KKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLG VMIYELLYGYPPWMDDT----------YQRLLNRIL------SQPLTFPEN--------VQIIPELKELLRRMMTIDEEQRIS----------WDEIFLH ...||.|.|||| .|. . ..|. .....|| . ... ||.| |...... | |.|. .|| | CLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNH PLM | PWF |
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| Kinase | 21109.AA | Pkinase | 48-311 | 26 | 7.5e-75 | 259.77 | Pfam | 1-293 (293) | Show / Hide |
Range on Protein: 48-311 Range on HMM: 1-293/293 Sequence Identity: 26% (79 aa) YITKQNLGKGAFGSVFIAYRLTKEGKKNGKFAAKVIQLTTLNDKEIIQLTR--EIEILKTIRHDNIVKMEHVTRTKNNLYLFLEYIKDG----DLSKYLE | ... .|.|.||.|..... . ..| |.| . . .... ....| ||.|.| ..|.|||.. .. ..|...|. .|| | ||. |.. YHIGRKIGSGSFGCVYKCHHKGTGK----IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIS --NKRRL--SQEETVFFFRQIVNGFKELYKRNIIHRDIKPENILLEKKENHK--RLLISDFGFARVVNQDQMNKQIEQTPVGSLKYMAPQILG-IINFSC ..... | .| |...||. | . .....|||||.||||||. ...| .. |.|||.|.... |.. .|..|.. |||| .. . TWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGP KCDVWSLGVMIYELLYGYPPWMDD------TYQRLLNRILSQPLTFPENVQII-------------------PELKELLRRMMTIDEEQRISWDEIFLHP |.|.||.|...||.| |.||. .. . . ...||.. || |.. . .|.|...... . | ..|.....|. || KVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHP LM . WF |
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| Kinase | 21109.AA | Ciliate-E2c | 49-311 | 33 | 1.3e-68 | 234.26 | In-house | 1-310 (310) | Show / Hide |
Range on Protein: 49-311
Range on HMM: 1-310/310
Sequence Identity: 33% (106 aa)
ITKQN-LGKGAFGSVFIAYRLT-----KEG-KKNGKFAAKVIQLTTL-----NDKEII-QLTREIEILKTIRHDNIVKMEHVTRTKNNLYLFLEYIKDGD
| . | ||.| .|.|. ||. . ... . | || | ..| . |.|.| . |||...|. | .|.|. |....||..|| .|.
IDRNNILGSGSYGKVYKAYYCEDYQNEINNVQMNQLFAIKMTCLKNKDIHMINEKDIKESIIREINMMKHMNHPHIIKFYDAKQTDKHIYLIMEYCNGGT
LSKYLENKRRLSQEETVFFFRQIVNGFKELYKR-NIIHRDIKPENILLEKKENHKRLLISDFGFARVVNQDQMNKQIEQ---TPVGSLKYMAPQILGIIN
| .|...| ... .. .. | ||...||.|.| ||.||||||||||. . . . | ||||.. .. | |.|. | | .|. ||||||| .|
LEQYIYHKPKPNEKQCLYYFSQIISAFKYLHKEKNIFHRDIKPENILIHNGM----IKIADFGFSKICQDD--NIQNTQGFNTCCGTPMYMAPQILEGKN
FSC-KCDVWSLGVMIYELLYGYPPWM------------------DDTYQRLLNRIL---------------SQPLTFPEN--VQIIPELKELLRRMMTID
| |.|||||. |. |. .|| ..| . | | |...|||| . | .|.|.|...| |
YYTEKSDIWSLGVTLYYMLCYKLPWESIQEYDSHNICNHCYPWWQNTMKHLKQHIWEYFNPQASAAGVSPITQNIHFPENYEQNISQEVKQLIHKMLQVD
EEQRISWDEIFLHPLM
|| ||.||||| |..
EEKRIDWDEIFNHECI
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| Kinase | 21109.AA | CAMKL | 48-311 | 29 | 9.1e-68 | 215.29 | In-house | 1-297 (297) | Show / Hide |
Range on Protein: 48-311 Range on HMM: 1-297/297 Sequence Identity: 29% (91 aa) YITKQNLGKGAFGSVFIAYR-LTKEGKKNGKFAAKVIQLTTLNDKEIIQ-------------LTREIEILKTIR---HDNIVKMEHVTRTKNN------L |. . ||||.|| | | .| . | | |.| ........ ..|||.|.| .. | ||.|. .| |... . YRIGKTLGKGSFGKVKLATHIRTT----GEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKI YLFLEYIKDGD--LSKYLENK----RRLSQEETVFFFRQIVNGFKELYKRNIIHRDIKPENILLEKKENHKRLLISDFGFARVVN-Q-DQMNKQIEQTPV ||..||. |. | |.... .|.. .|. ..||||| . . . ...|.||||||||||| .. |. . |.||||. . .. .. . | YLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNN-NIKIIDFGFSNMYRPCIFGPGQKLK-TFC GSLKYMAPQILGI--INFS-CKCDVWSLGVMIYELLYGYPPWMDDTYQ-------RLLNRILSQPLTFPENVQIIPELKELLRRMMTIDEEQRISWDEIF ||. |||| |. . | |.||.||. | ...|| |. ||||. .|...| .. .| ... ... |.|.|.. . |.|.. ..| GSPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIM LHPLM || | NHPWM |
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| Kinase | 21109.AA | Ciliate-E2-Unclassified | 48-311 | 24 | 2.7e-63 | 216.58 | In-house | 1-352 (352) | Show / Hide |
Range on Protein: 48-311 Range on HMM: 1-352/352 Sequence Identity: 24% (88 aa) YITKQNLGKGAFGSVFIAYRLTKEGKK-----NGKFAAKVIQLTTLNDKEIIQLTREIE----------------ILKTIRHDNIVKMEHVTRTKNNLYL |. . .|.|.||.|. ... . .. . |. . .. .| ||.. |.. ||. . | .||||... ..|.|.|. YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI FLEYIKDGDLSKYLENK-----------------RRLSQEETV-----FFFRQIVNGFKELYKRN-IIHRDIKPENILLEKKENHKRLLISDFGFAR--- .||...|||..|.... .... .... |.|.||..|.. | . | ||||||||||||. .. . .. |.|||... VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ VVNQDQMNK----------QIEQTPVGSLKYM----APQILGIINFS----CKCDVWSLGVMIYELLYGYPPWMDDTYQR----------------LLNR |... .. |. .| .|.. || || .|. | . |||.||||| .||.|.||.| | .. |.. QNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQN ILSQPLTFP--EN----VQIIPELKELLR----RMMTIDEEQRISWDEIFLHPLM |. ... || .. .. || |.... .|. . ..||....|. ||.. IKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF |
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| Kinase | 21109.AA | CAMK-Unique | 48-311 | 20 | 1.7e-58 | 191.6 | In-house | 1-363 (363) | Show / Hide |
Range on Protein: 48-311
Range on HMM: 1-363/363
Sequence Identity: 20% (76 aa)
YITKQNLGKGAFGSVFIAYRLTKEGKKNGKFAAKVIQL-TTLNDKEIIQ-----------------LTREIEILKTIRHDNIVKMEHV----TRTKN---
|.. . .|.|.|| |... ...| .| |.| |.... | |.| ..| |.||..|.|. | ||.| ... ...
YKMHRIIGHGNFGHVYEC--MDRETGK--KWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPL
------------NLYLFLEYIKDGDLSKYLEN--------------------KRRLSQ--EETVFFFRQIVNGFKELYKRNIIHRDIKPENILLEKKEN-
..|...||. .|||.... ....| .| | ..... . . . .|.|||.|.|||.. . ..
CDLIIKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKD
------------HKRLLISDFGFARVVNQDQMNKQIEQTPVGSLKYMAP--------------QILGIINFSCKC----DVWSLGVMIYELLYGYPPWMD
... ..||| .. .|. .|. . || .|.. |||| .... ...| | |||||. |..| |.||
NNHHRDFPYDWSNWHIKLCDFGLCCHYNHNKMCH-MMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDC
DTYQ--------RLLNRILSQPL-TFPENVQII-----PELKELLRRMMTIDEEQRISWDEIFLHPLM
.. ... .|.. . .|.. . . .|.| .. . ||.| .|.| |. |.
ECEDRDYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI
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| Kinase | 21109.AA | RSK | 51-311 | 29 | 5.5e-58 | 198.97 | In-house | 1-278 (278) | Show / Hide |
Range on Protein: 51-311 Range on HMM: 1-278/278 Sequence Identity: 29% (83 aa) KQNLGKGAFGSVFIAYRLTKEGKKNGKFAAKVIQLTTLNDKEI-IQLTR-EIEILKTIR-HDNIVKMEHVTRTKNNLYLFLEYIKDGDLSKYLENKRR-- . ||.|..|.||. . | . ... .| ||.. .. .. . |. |..||.... | .||. .. .|. ||| .||.. |.| . |..... LKVLGQGGYGKVFLCRKCTHH-DTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFG -LSQEETVFFFRQIVNGFKELYKRNIIHRDIKPENILLEKKENH-KRLLISDFGFARVVNQDQMNKQIEQTPVGSLKYMAPQILG---IIN-FSCKCDVW .| .| | ...|| . | .. |||||.||||||.. .. . .. ..||||.. . ..| .|..... |||| .| . . ||.| CFSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDES-NEGHIKLTDFGFCKQF--RCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWW SLGVMIYELLYGYPPWMD---DTYQRLLNRILSQP--LTFPENVQIIPELKELLRRMMTIDEEQRIS-----WDEIFLHPLM |||| .||.| |.|| .. . ...||.. ||.|.. . .| |.|.|.|.. |...|.. .|| || . SLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF |
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| Kinase | 21109.AA | Pkinase_Tyr | 48-255 | 26 | 1.7e-23 | 80.17 | Pfam | 1-216 (270) | Show / Hide |
Range on Protein: 48-255 Range on HMM: 1-216/270 Sequence Identity: 26% (61 aa) YITKQNLGKGAFGSVFIAYRLTKEGKKNGKFAAKVIQLTTLNDKE--IIQLTREIEILKTI-RHDNIVKMEHVTR-TKNN--LYLFLEYIKDGDLSKYLE . . ||.||||.|. .. ...... . | |.. . ... . . ||..|.|.. .|.|||.. | . .|. .|| . ||| .|| ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR N----KRRLSQEETVFFFRQIVNGFKELYKRNIIHRDIKPENILLEKKENHKRLLISDFGFARVVNQDQMN-KQIEQTPVGSLKYMAP-----QILGIIN . |..|. .. . . .|| .| | .|.||||. |.|... . |.||| || . | .. . .. | ||| . KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE---NNVVKICDFGLARDIYNDDYYYRKRGGGK-LPIKWMAPECINYGK----- FSCKCDVWSLGVMIYELLY-GYPP-W |. | |||| || ..|.. | | . FTTKSDVWSFGVLMWEIFTYGEQPTY |
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| Kinase | 21109.AA | TyrKc | 48-311 | 24 | 1.5e-17 | 61.21 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 48-311 Range on HMM: 1-280/280 Sequence Identity: 24% (73 aa) YITKQNLGKGAFGSVFIAYRLTKEGKKNGKFAAKVIQLTTLNDKEIIQLTREIEILKTI--RHDNIVKMEHVTRTK-------NNLYLFLEYIKDGDLSK .. || |||| |. . . | |... . . . ||..|.. . .|.|||.. | ... |.. .|| . ||| . ITLGKKLGEGAFGEVYKGTWK-------IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD YLENKRR-LSQEETVFFFRQIVNGFKELYKRNIIHRDIKPENILLEKKENHKRLLISDFGFARVVNQD-------QMNKQIE--QTP-VGSLKYMAPQIL || ..|. |. .. . | || .| | ..|.||||. |.|. .. . ||||| .| . | .. .. | .. . .. ||| . YLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI GIIN-FSCKCDVWSLGVMIYELL-YGYPPWMD-----DTYQRLLNRILSQ-PLTFPEN------VQIIPELKELLRRMMTIDEEQRISWDEIFLHPLM . |. | |||| ||...|.. || .|. . . |...... . . |.| | .|. .. .. | |.| . || | .. -NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF |
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