Gene 18780 (Tetrahymena)

18780

Species: Tetrahymena
Alias: TTHERM_00237360, 469, 20.m00244, 3706.m00011, 18780, PreTt18780
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: ULK
Subfamily: ULK

Sequence

Name Sequence Type Origin Length Description Download
18780.AA Protein None 531 None Fasta, JSON
18780.kin_dom Protein Kinase Domain None 255 None Fasta, JSON
18780.NA RNA None 1596 None Fasta, JSON

Protein domain

Protein domains of 18780.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 18780.AA ULK 13-267 32 1.4e-104 353.79 In-house 1-324 (324) Show / Hide 
Range on Protein: 13-267
Range on HMM: 1-324/324
Sequence Identity: 32% (105 aa)

LQGKTELGKGAFA-IVYPG--KDTH-KNKLVAIKKID--AIKNKDYL-------DKIDQECQLHQSLLH-----NCHVLEFIDNFSEE--NYIYIITELC
 . . .||||.|.  || |  |.|. .|..||.|.||   ...| ..       .....| |. . | .     . |. ...| | .   |.||||.|.|
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNH-HIVKLYDWFETSNHNNIYIIMEYC

EFGDLDSFVNRF-------ENRTLPEDVAKLFTNQILLGFIALYDLDIIHRDMKLQNILINKNF------------ECKIADFGLAKSCQE------IGH
. |||... ..        |...|.|. |. |  ||. || .|..  |||||.|.|||||....             .||||||.||....      . .
NGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQ

TYA------GTPLTMAPEVLFGL----EYN-KKCDVWSFGCIVYAMTHGRYP----FFPTGHNKRQELEDM-------VRDRRLEFIN----PQISKECK
|.       ||||.|||..| |.    .|. .|||.||.||| | |  |.||    | .. ..  |.| ..       .... ..| .    |.||.|||
TCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSWFNDQYLY-IQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECK

QFIDKMLKVNPEERIDLFGLFNEPWL
..| .||......||.   .|| ||.
DLIRRMLQYDEKDRISWEEIFNHPWF
Kinase 18780.AA ULK 13-267 32 4.7e-104 351.98 In-house 1-329 (329) Show / Hide 
Range on Protein: 13-267
Range on HMM: 1-329/329
Sequence Identity: 32% (108 aa)

LQGKTELGKGAFAIVYPG--KDTH--KNKLVAIKKID----AIKNKDY-----LDKIDQECQLHQSLL-------HNCHVLEFIDNFSEE--NYIYIITE
 . . .||||.|. || |  |.|.  .|..||.|.||     .||...     .. ...|... . |        |.... ...| | .   |.||||.|
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

LCEFGDLDSFVN---RF-----ENRTLPEDVAKLFTNQILLGFIALYDLDIIHRDMKLQNILINKNF------------ECKIADFGLAKSCQE------
.|. |||... .   ..     |...|.|. |. |  ||| || .|..  |||||.|.|||||....             .||||||.||....      
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

IGHTYA------GTPLTMAPEVLFGL----EYN-KKCDVWSFGCIVYAMTHGRYPFFPTGHNKRQ-----ELEDM-------VRDRRLEFI----NPQIS
. .|.       ||||.|||..| |.    .|. .|||.||.||| | |  |..||.    |. .     .| .        .... |.|     .||||
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQIS

KECKQFIDKMLKVNPEERIDLFGLFNEPWL
.|||..| .||......||.   ||| ||.
PECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 18780.AA S_TKc 13-267 30 8.8e-74 252.34 SMART 1-231 (231) Show / Hide 
Range on Protein: 13-267
Range on HMM: 1-231/231
Sequence Identity: 30% (83 aa)

LQGKTELGKGAFAIVYPGKDTHKNKLVAIKKIDAIKNKDYLDKIDQECQLHQSLLHNCHVLEFIDNFSEENYIYIITELCEF--GDLDSFVNRFENRT--
 .   ..|||||. || ..... ...||||.|.        ..| .| |....  |  ..  ..| | . ...|...|.|.   ||| ..  .   .   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--LPEDVAKLFTNQILLGFIALYDLDIIHRDMKLQNILINKNFECKIADFGLAKSCQEIGHTYAGTPLTMAPEVLFGLEYNK-KCDVWSFGCIVYAMTHG
  .|| .|. .. ||...   . .. ||||| | .|||...  . ||.|||||.      .|. |||  ||||||    |.| |||.||.|||.| |  |
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCG

RYPFFPTGHNKRQELEDMVRDRRLEFINPQISKECKQFIDKMLKVNPEERIDLFGLFN-------EPWL
. ||        |.. ....           |.|.|.||.|.|...||.|.    ...        ||.
YPPFP-----QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 18780.AA CAMK 18-267 20 2.8e-70 225.41 In-house 1-425 (425) Show / Hide 
Range on Protein: 18-267
Range on HMM: 1-425/425
Sequence Identity: 20% (87 aa)

ELGKGAFAIVYPGKDTHKN------------KLVAIKKIDAIKNKD---------------------------YLDKIDQECQLHQSL------LHNCHV
.||.|.|..|. ..... .            . |||| ||  | ||                            .... .| .....|      |.  ..
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

LEFID---------------NFSE-----ENYIYIIT---ELCEFG----DLDSFVNRFEN-------------RTLPEDVAKLFTNQILLGFIALYDLD
. ...               . |      ....|...   |.|. |    || ... . ..             . ..|. |. .  ||. .   . ...
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IIHRDMKLQNILINKN-----------------FECKIADFGLAKSCQEIG--------------------------HTYAGTPLTMA-PEVLFG-----
|.||| |. |||...|                 .  ||.|||.|. ...                            .|. |||  || |||| |     
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

---------LEYNKKCDVWSFGCIVYAMTHGRYPFF-PTGHNKR---------QELEDMVRDRRLEFINPQ---------------ISKE--------CK
           |..|||.|| |.| |.|  |..||  ... . .         .||  ...  . .|. |.               ||.|        ||
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

QFIDKMLKVNPEERIDLFGLFNEPWL
..| |||.|.||.|. .    | ||.
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 18780.AA Pkinase 13-267 28 4.5e-69 240.58 Pfam 1-293 (293) Show / Hide 
Range on Protein: 13-267
Range on HMM: 1-293/293
Sequence Identity: 28% (86 aa)

LQGKTELGKGAFAIVYPGKDTHKNKLVAIKKIDAIKNKDYLDKIDQ---ECQLHQSLLHNCHVLEFIDNFSEENYIYIITELCEFG----DLDSFVNRFE
.. .  .|.|.|. || ...   .|.||.|.|.  ..|.  |...    |.|....| . .......| | ....||...|.|| |    || ... . .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

NRTL--PEDVAKLFTNQILLGFIALYDLDIIHRDMKLQNILINKNFEC----KIADFGLA----KSCQEIGHTYAGTPLTMAPEVLF-GLEYNKKCDVWS
....  .|...| .  ||| |   ...  |||||.|..||||..| ..    ||.|||||       ..  .|..|||  |||||.  | .| .|.|.||
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

FGCIVYAMTHGRYPFFPT----GHNKRQELEDMVRDRRLEFINPQIS--------------------KECKQFIDKMLKVNPEERIDLFGLFNEPWL
.|||.| |  || ||       . .  ... .......|.|  |. .                    .|||.||...|...|..|.    ... ||.
CGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 18780.AA Ciliate-E2 19-267 23 1.9e-65 223.62 In-house 7-365 (365) Show / Hide 
Range on Protein: 19-267
Range on HMM: 7-365/365
Sequence Identity: 23% (87 aa)

LGKGAFAIVYPGKDTHKNKLVAIK-----------------KIDAIKNK-----DYLDKIDQEC--------QLHQ-----SLLHNCHVLEFIDNFS--E
.|.|.|..|| .|.  ..|..|||                 || |.|..      .. ......        .. .     ..| . ....... |    
IGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKI-NEKNILEQLNHPNIIKMYECFQEKD

ENYIYIITELCEFGDLDSFVN-----RFENRT----LPEDVAKLFTNQILL---------------GFIALYDLD-IIHRDMKLQNILINKNFECKIADF
.|.||...|.|. ||| .. .     |.....    . |  .| .. |||                ..  |     ||||| |..|||.     .||.||
DNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDF

GLAKSCQ----------------------------------EIGHTYAGTPLTMAPEVLFGLE---------YNKKCDVWSFGCIVYAMTHGRYPFFPTG
||.| ..                                  .. .|..|||  ||||.| | .         |..|||.||.|.| | |  |..||    
GLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF----

HNKRQELEDMVRDRRLEFINP-----------------QISKECKQFIDK----MLKVNPEERID-LFGLFNEPWL
       ..   .  ..| .|                 ..|.|||..| |    ||...||.||.    ..| ||.
-------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 18780.AA AGC 13-267 19 4.5e-60 152.99 In-house 1-395 (395) Show / Hide 
Range on Protein: 13-267
Range on HMM: 1-395/395
Sequence Identity: 19% (77 aa)

LQGKTELGKGAFAIVYPGKDTH------KNKLVAIKKID---AIKNKD--YLDKIDQECQLHQSLLHN-------CHVLEFIDN----------------
 . .. .|||.|  ||  .. .       .|. |.|...    |. |.   ....  |.   |    .        ..|| ...                
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHW-KQ----DQGYVWEERNILEKCNHTHNHPIKSHHPFIVKI

----FSEENY--IYIITELCE--------FGDLDSFVNRF---ENRTLPEDVAKLFTNQ-------ILLGFIALYD-LDIIHRD-MKLQNILINKNFECK
    |  ...  .|.. |...         |....|   .    .....|..|. .. .       |.|..  | . ..||||| .|. |||....  .|
LHYSFQDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIK

IADFGLAKSCQEIG-----------------------------------------------------HTYAG--TPLTMAPEVLFGLEYNKKCDVWS--F
..||||.|     |                                                     .|  |  ||  ||||.|    |.| || ||  .
LTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGL

GCIVYAMTHGRYPFFPTGHN-------KRQELEDMVRDR------RLEFIN---------PQISKECKQFIDKMLKVNPEERID----------LFGLFN
||. | |  |. ||.    .        . |. . ....      ...| .         ...|.|.| .| |.|...||.|.              . |
GCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKN

EPWL
 || 
HPWF
Kinase 18780.AA Ciliate-E2-Unclassified 12-267 25 1.6e-58 200.72 In-house 1-352 (352) Show / Hide 
Range on Protein: 12-267
Range on HMM: 1-352/352
Sequence Identity: 25% (90 aa)

YLQGKTELGKGAFAIVYPGKD-THKNKLVAIKKIDAIKNKDYLDKID--------QECQLHQ---------------SLLHNCHVLEFIDNFSEENYIYI
|  .|. .|.|.|..||  ..  .| .. |.| .  |.... . .          .| . ..               . . . ... ... |  ...|||
YKIIKQ-IGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI

ITELCEFGDLDSFVNRFEN---------------RTLPEDVAK-----LFTNQILLGF-IALYDLDIIHRDMKLQNILINKN---FECKIADFGLAK---
..|.|| |||  . . ...               . ..|  ||      .. |||.|.    . ..||||| |..|||...|   ...||.|||..|   
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ

SC---------------QEIGHTYAGTPLTM----APEVLFGLEYN----KKCDVWSFGCIVYAMTHGRYPFFPTGHNK-------------RQELEDMV
..               |.. .| .||| .|    ||||| | .|.    .|||.||.|.| |.|  |.|||. .  ..             |..|..  
QNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNI

RDRRLEFIN-------PQISKECKQFID----KMLKVNPEERIDLFGLFNEPWL
 .. ..| .        ..|.|.| ||     ||||.||..||..  ..| ||.
KQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 18780.AA CAMKL 12-267 29 1.1e-50 159.84 In-house 1-297 (297) Show / Hide 
Range on Protein: 12-267
Range on HMM: 1-297/297
Sequence Identity: 29% (89 aa)

YLQGKTELGKGAFAIVYPGKDTHK-NKLVAIKKID--AIKNKDYLDK------------IDQECQLHQSLL---HNCHVLEFIDNFSEENY------IYI
|  || .||||.|. |  ....   .. |||| ||   |.|... .|            | .| |....|    |  ..  . . .  ...      ||.
YRIGK-TLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHP-NIIKLYEVIETPEHDIETKKIYL

ITELCEFGD--LDSFVNRFENRT--LPEDVAKLFTNQILLGFIALYDLDIIHRDMKLQNILINKNF--ECKIADFGLAKSCQEI----GH---TYAGTPL
..|.|. |.  |  .. . ..|   .||. |. .  ||. .   . ...|.||| |. |||. .|     ||.|||..  ....    |.   |  |.| 
VMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPP

TMAPEVLFG--LEYN-KKCDVWSFGCIVYAMTHGRYPF-FPT----GHNKRQELEDMVRDRRLEF-INPQISKECKQFIDKMLKVNPEERIDLFGLFNEP
 ||||.. |   .|. .| |.|| | | |||  |..||  .|    | .   .|. ...    .. | ...| .|...| |||.||||.|. .  . | |
YMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHP

WL
|.
WM
Kinase 18780.AA STE 13-267 19 8.3e-50 171.78 In-house 1-359 (359) Show / Hide 
Range on Protein: 13-267
Range on HMM: 1-359/359
Sequence Identity: 19% (72 aa)

LQGKTELGKGAFAIVYPGKDT------HKNKL---------VAIKKID----------------AIKNKDYLDKIDQECQLHQSLLH-NCHVLEFIDNFS
..|  ..|||||  || ...       .....         .|||...                 .||.. ...| .| .... . |   .. .... . 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

EE-------NYIYIITELCEFGDLDSFVNR-----FENR-------TLPEDVAKLFTNQILLGFIALYD-LDIIHRDMKLQNILINKNFECKIADFGLAK
 |       ....|. |... | ||.....     ...        ..||.. . .. ||| |. ..   . ||||| | .|||.     .|..|||...
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

SCQEIGH-------------------TYAGTPLTMAPEVLFG------LEYNKKCDVWSFGCIVYAMTHGRYPFFP-TGHNKRQELEDMVRDRR------
. ....                    | .|||  |||||. .       .|. |||.||.|| .  |  |..|..  . .    .  .. .  .      
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

------LEFINP------------------QISKECKQFIDKMLKVNPEERIDLFGLFN--EPWL
        . ..                  . |.|.|.||.| |. .|..| .   | .   |..
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 18780.AA SAK 14-267 35 3.5e-47 158.61 In-house 2-254 (254) Show / Hide 
Range on Protein: 14-267
Range on HMM: 2-254/254
Sequence Identity: 35% (91 aa)

QGKTELGKGAFAIVYPGKDTHKNKLVAIKKID--AIKNKDYLDKIDQECQLHQSLLHNCHVLEFIDNFSEENYIYIITELCEFGDLDSFVNRFENRTLPE
| .  ||||.|| ||  |  |  . |||| ||  ....    ... .| ..|  | |   .||    | ..||.|.. |.|. |..  ....   |   |
QVQHLLGKGGFACVYRAKCIHTHQEVAIKMIDKKLMQKTGMVQRVRNEVEIHCQLKHPS-ILELYNYFEDNNYVYLVLEMCHNGEMHRYMKH-RMRPFTE

DVAKLFTNQILLGFIALYDLDIIHRDMKLQNILINKNFECKIADFGLA---KSCQEIGHTYAGTPLTMAPEVLFGLEYNKKCDVWSFGCIVYAMTHGRYP
. |. | .||. |.. |   .|.|||. | |||. .. .|||||||||   |  .|   |  |||  ..||.        . |||| ||..| .  || |
EEARHFMHQIVIGMLYLHSHGIMHRDLTLSNILLTRDMHCKIADFGLATQLKMPHEKHYTMCGTPNYISPEIATRTAHGLQSDVWSLGCMLYTLLIGRPP

FFPTGHNKRQELEDMVRDRRLEFINPQ-ISKECKQFIDKMLKVNPEERIDLFGLFNEPWL
|       .. |  ..     |.| |  .| | .  |.|||. ||.||| |      |..
F--DTDAVKNTLNKVM---MAEYIMPAHLSMEAQDLIHKMLRKNPHERITLSTVLCHPFM
Kinase 18780.AA PLK 12-209 35 1.4e-39 126.63 In-house 1-202 (258) Show / Hide 
Range on Protein: 12-209
Range on HMM: 1-202/258
Sequence Identity: 35% (72 aa)

YLQGKTELGKGAFAIVYPGKDTHKNKLVAIKKID--AIKNKDYLDKIDQECQLHQSLLHNCHVLEFIDNFSEENYIYIITELCEFGDLDSFVNRFENRTL
| .|.  ||||.|| .|  .| | .. .||| ..   .. .   .|..|| ..| .| |  ....|.. |  ....||  |.|. ..|    .|   ..|
YERGHF-LGKGGFAKCYEMTDIHTKQVYAIKVVPKSLMQKPHQREKMKQEIEIHRQLHHP-NIVKFHHFFEDHENVYIVLEYCHNRSLMHYHKRR-AKRL

PEDVAKLFTNQILLGFIALYDLDIIHRDMKLQNILINKNFECKIADFGLAKSCQEIGH---TYAGTPLTMAPEVLFGLE--YNKKCDVWSFGCIVYAMTH
 |. .. .. ||  |   | .  |||||.|| |...|.| ..||.|||||  .   |.   |  |||   ||||| | .  .  . |.||.|||.|..  
TEPEVRYYMYQIVQGLKYLHQHRIIHRDLKLGNLFLNDNMHVKIGDFGLATRLEYDGERKKTMCGTPNYIAPEVLDGNKQGHSYEVDCWSLGCIMYTLLI

GRYPF
|. ||
GKPPF
Kinase 18780.AA TyrKc 13-259 21 2.6e-16 40.96 SMART 1-280 (280) Show / Hide 
Range on Protein: 13-259
Range on HMM: 1-280/280
Sequence Identity: 21% (63 aa)

LQGKTELGKGAFAIVYPGKDTHKNKLVAIKKIDAIKNKDYLDKIDQECQLHQSL-LHNCHVLEFIDNFSEE-------NYIYIITELCEFGDLDSFVNRF
.. . .|| ||| .|| |. .     ||.|.. . .    .  . .| ..  .|  |. ... ..   ...         ..|..|... |||...  . 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

ENRTLPEDVAKLFTNQILLGFIALYDLDIIHRDMKLQNILINKNFECKIADFGLAKSCQEI------GHTYA-----GTP--LT---MAPEVLFGLEYNK
... |. .    |  ||  |   | .  .||||    |.|...|. .||.||||..   .       . .|      |.   |    ||||...  ... 
RPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTT

KCDVWSFGCIVY-AMTHGRYPFFP-TG--HNKRQELEDMVRDRRLEFINP-------QISKECKQFIDKMLKVNPEER------IDLF
| ||||||   .  .| |  |    .    . .. .|.  . .|..             ..|  | . .  . .||.|      ...|
KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 18780.AA Pkinase_Tyr 133-196 35 2.7e-11 38.9 Pfam 132-201 (270) Show / Hide 
Range on Protein: 133-196
Range on HMM: 132-201/270
Sequence Identity: 35% (25 aa)

IIHRDMKLQNILINKNFECKIADFGLAKSCQEIGHT-YAGTPLT-----MAPEVLFGLEYNKKCDVWSFG
.||||    |.|...|. .||.|||||.  .. .   ....        ||||...  ... | ||||||
CIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFG
Kinase 18780.AA PLK 233-267 37 1.4e-07 20.87 In-house 224-258 (258) Show / Hide 
Range on Protein: 233-267
Range on HMM: 224-258/258
Sequence Identity: 37% (13 aa)

NPQISKECKQFIDKMLKVNPEERIDLFGLFNEPWL
...||.| |..|.|||. ||.||. .  ... |..
HCPISDEAKDLIQKMLNWNPDERPTIDQILQHPFF
Kinase 18780.AA Pkinase_Tyr 83-100 44 0.004097 11.17 Pfam 80-97 (270) Show / Hide 
Range on Protein: 83-100
Range on HMM: 80-97/270
Sequence Identity: 44% (8 aa)

NYIYIITELCEFGDLDSF
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NQIYIVMEYMPHGDLLDY
Kinase 18780.AA Pkinase_Tyr 13-44 30 1.467082 2.52 Pfam 1-36 (270) Show / Hide 
Range on Protein: 13-44
Range on HMM: 1-36/270
Sequence Identity: 30% (11 aa)

LQGKTELGKGAFAIVYPGKDT----HKNKLVAIKKI
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ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML