Gene 13838 (Tetrahymena)

13838

Species: Tetrahymena
Alias: PreTt13838, 862, 13838, 17.m00445, TTHERM_00213560
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: ULK
Subfamily: ULK

Sequence

Name Sequence Type Origin Length Description Download
13838.AA Protein None 562 None Fasta, JSON
13838.kin_dom Protein Kinase Domain None 257 None Fasta, JSON
13838.NA RNA None 1689 None Fasta, JSON

Protein domain

Protein domains of 13838.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 13838.AA ULK 12-268 31 1.8e-119 403.18 In-house 1-324 (324) Show / Hide 
Range on Protein: 12-268
Range on HMM: 1-324/324
Sequence Identity: 31% (103 aa)

LIDKEVLGKGAFA-TVVKGLDLKN---NQHIACKIVSKQKLKENPTLDN------LFAQEIQLQRQLK---SPY--IIQLYKVYSVD--NYYMLMMEYCE
 . ...||||.|. .| || . |.   ||..|||...|.|..... ...      |. .|||....||   .|.  |..||...  .  |.. ..||||.
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

GGDLEKYLQKNGP---------IPEQKAIGFLMQVLAGLREIHSHSIIHRDLKPQNIFIKGNQ-------------LKIGDFGCARTAFIDSL--NVGKT
|||||.|..||..         ..||.||.|..| ..|..|.|.| |||||.||||| |. .|             |||.||| |.. . ...  .. .|
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

TV------GSSYFKAPEIIEGL----EYG-FEVDIFSLGVLLYKMLFNSYPFEGQSVQEIYKK--------------MQSVSIDFKK--NGVVISNQMID
.|      |. .. ||.|..|.    .|. ...||.|||...| ||...|||...  .. |..              ..   |.|.|  ....||....|
CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKD

FLQRLLKFDRNDRITWLQVYQHPVI
...|.|..|..|||.| ....||..
LIRRMLQYDEKDRISWEEIFNHPWF
Kinase 13838.AA ULK 12-268 31 8.10000000001e-117 394.39 In-house 1-329 (329) Show / Hide 
Range on Protein: 12-268
Range on HMM: 1-329/329
Sequence Identity: 31% (103 aa)

LIDKEVLGKGAFATVVKGLDLKN----NQHIACKIVSKQKLKENPTLDN------LFAQEIQLQRQLK----SPY----IIQLYKVYSVD--NYYMLMME
 . ...||||.|..| || . |.    |. .|||...|||..... ...      |. .||.....||    ...    |..||...  .  |.. ..||
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

YCEGGDLEKYLQKNGP----------IPEQKAIGFLMQVLAGLREIHSHSIIHRDLKPQNIFIKGNQ-------------LKIGDFGCARTAFID--SLN
||.|||||.|..||..          ..||.|| |..| |.|..|.|.| |||||.||||| |. .|             |||.||| |..   |  . .
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

VGKTTV------GSSYFKAPEIIEGL----EYG-FEVDIFSLGVLLYKMLFNSYPFEGQSVQEIY-----KK----------MQSVSIDFKK--NGVVIS
. .|.|      |. .. ||.|..|.    .|. ...||.|||...| ||.. .||...  .. |     |           ...  ..|.|  |...||
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQIS

NQMIDFLQRLLKFDRNDRITWLQVYQHPVI
....|...|.|..|..|||.| ....||..
PECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 13838.AA S_TKc 12-268 30 1.3e-80 275.05 SMART 1-231 (231) Show / Hide 
Range on Protein: 12-268
Range on HMM: 1-231/231
Sequence Identity: 30% (84 aa)

LIDKEVLGKGAFATVVKGLDLKNNQHIACKIVSKQKLKENPTLDNLFAQEIQLQRQLKSPYIIQLYKVYSVDNYYMLMMEYCEG--GDLEKYLQKNGP--
    ...|||||..| |. . | ... |.||..           . . .|||. .. . |.|..|| |.   ... . ||||.|  ||| .|..|.|.  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----IPEQKAIGFLMQVLAGLREIHSHSIIHRDLKPQNIFIKGNQLKIGDFGCARTAFIDSLNVGKTTVGSSYFKAPEIIEGLEYGF-EVDIFSLGVLLY
    .||  |  .. |.. .|  .||| ||||||||.||..   ..||.||| ||          .| .|. .. |||..    ||. ..|. |.|..||
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

KMLFNSYPFEGQSVQEIYKKMQSVSIDFKKNGVVISNQMIDFLQRLLKFDRNDRITWLQVYQ-------HPVI
 ||    ||.   .|...||.              | ...||....|..| ..|.|  .. |       || .
EMLCGYPPFP--QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 13838.AA CAMK 17-268 22 2e-77 248.88 In-house 1-425 (425) Show / Hide 
Range on Protein: 17-268
Range on HMM: 1-425/425
Sequence Identity: 22% (94 aa)

VLGKGAFATVVKGLDLKNN------------QHIACKIVSKQKLKE------------------------NPTLDNLFAQEIQLQRQ-------LKSPYI
.||.|.|..| .. . ...            |. |.||..|.|||.                        .|     . .||.. ..       |. | |
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IQLYKVYS--------------------VDNYYMLM--MEYCEGG----DLEKYLQKNGP---------------IPEQKAIGFLMQVLAGLREIHSHSI
|.|| ||                      ...|| |  ||||.||    ||  |....|.               ..|. |  .  |.. ... .||| |
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

IHRDLKPQNIFIKGN------------------QLKIGDFGCARTAFIDSLNV----------------------GKTTVGSSYFKA-PEIIEG------
.|||||| || .  |                  ..|| ||| |.  . .. |                        || .|. .. | ||...|      
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

--------LEYGFEVDIFSLGVLLYKMLFNSYPFEGQ-------------SVQEIYKKMQSVSIDFKKN-------------GVVISNQ--------MID
          ||...|. |.||.|| ||   .||.|              . .|...| ..   ||                   ||..         .|
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

FLQRLLKFDRNDRITWLQVYQHPVI
.....|. | ..|.|  |. .|| .
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 13838.AA Pkinase 12-268 29 6.3e-72 250.07 Pfam 1-293 (293) Show / Hide 
Range on Protein: 12-268
Range on HMM: 1-293/293
Sequence Identity: 29% (87 aa)

LIDKEVLGKGAFATVVKGLDLKNNQHIACKIVSKQKLKENPTLDNLFA-QEIQLQRQLKSPYIIQLYKVYSVDNYYMLMMEYCEGG----DLEKYLQ--K
.  ....|.|.|..| |. . ....  |.||..|.. |..  . ...  .|||. . |..|.|..|| ..  .... . |||||||    ||  |..  .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSW-KDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

NGPI--PEQKAIGFLMQVLAGLREIHSHSIIHRDLKPQNIFIK-GNQL----KIGDFGCARTAFIDSLNVGKTT-VGSSYFKAPEIIE-GLEYGFEVDIF
.|..  .|. .. .. |.| ||  .||..||||||||.||.|.  ...    ||.|||.|. .     |.  || .|.... |||.|  | .|| .||..
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMW

SLGVLLYKMLFNSYPFEGQ------SVQEIYKKMQSVSIDFK-------------------KNGVVISNQMIDFLQRLLKFDRNDRITWLQVYQHPVI
|.|..|| ||.   || |.      . ......  .  ..|                    .. . .|  ..||. ..|..| ..|.|. |. ||| .
SCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 13838.AA Ciliate-E2 12-268 22 1e-69 237.92 In-house 1-365 (365) Show / Hide 
Range on Protein: 12-268
Range on HMM: 1-365/365
Sequence Identity: 22% (86 aa)

LIDKEVLGKGAFATVVKGLDLKN-----------------------NQHIACKIVSKQKLKENPTLDNLFA---------QEIQLQRQLKSPYIIQLYKV
 .  ...|.|.|..| |. . |.                       .. .| ||..|.....    ....          .| ....||..|.||..| .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

YS--VDNYYMLMMEYCEGGDLEKYLQKN-----------GPIPEQKAIGFLMQVLA---------------GLREIHSHS-IIHRDLKPQNIFIKGNQLK
.    ||.. | ||||.||||..|...|           ... |.... .  |.|                .|...||   |||||.||.||..    .|
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----IK

IGDFGCAR---------------TAFIDSL----------------NVGKTTVGSSYFKAPEIIEGLE---------YGFEVDIFSLGVLLYKMLFNSYP
| ||| ..                 ...                  |. .|..|. ...||||..| .         |....||.||||.|| |||. .|
IIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

FEGQSVQEIYKKMQSVSIDFKKN---------------GVVISNQMIDFLQR----LLKFDRNDRIT-WLQVYQHPVI
|        ... .   ||| ..                  .|....|....    .|. | . ||| | |. .|| .
F--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 13838.AA CAMKL 11-268 28 1.7e-65 207.91 In-house 1-297 (297) Show / Hide 
Range on Protein: 11-268
Range on HMM: 1-297/297
Sequence Identity: 28% (86 aa)

FLIDKEVLGKGAFATVVKGLD-LKNNQHIACKIVSKQKLKENPTLDNLFAQ-----------EIQLQRQLK---SPYIIQLYKVYSVDNY------YMLM
. | | .||||.|..|  ... . .... | ||. |.|....|  .. .             |||....|.    | ||.|| |.  ...      . | 
YRIGK-TLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLV

MEYCEGGD--LEKYLQKN----GPIPEQKAIGFLMQVLAGLREIHSHSIIHRDLKPQNIFIKGNQ---LKIGDFGCARTAF---IDSLNVGKTTVGSSYF
||||.||.  |  |..|.    |..||  |  .  |.....  .||| |.|||.|| || .  |.   .|| ||| .       . . .  ||  ||  .
MEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPY

KAPEIIEG--L-EYGFEVDIFSLGVLLYKMLFNSYPFE-------GQSVQEIYKKMQSVSIDFKKNGVVISNQMIDFLQRLLKFDRNDRITWLQVYQHPV
 ||||..|     .|..||| |.||.|| |..  .||.       |.. .  ..... .   .    . .| . .|.....|. . ..|.|  |. .|| 
MAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPW

I
 
M
Kinase 13838.AA Ciliate-E2-Unclassified 13-268 22 1.7e-60 207.3 In-house 2-352 (352) Show / Hide 
Range on Protein: 13-268
Range on HMM: 2-352/352
Sequence Identity: 22% (81 aa)

IDKEVLGKGAFATVVKGLDLKNNQHI-----ACKIVSKQKLKENPTLDNLFAQEIQLQRQ------------------LKSPYIIQLYKVYSVDNYYMLM
.  ...|.|.|..| |  . |..  .     ..|| .. ... .    ..  ........                  ...|.|. .. .   ...  . 
KIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

MEYCEGGDLEKYLQKNGP-----------------IPEQKAI-----GFLMQVLAGLREIHSHS-IIHRDLKPQNIFIKGN----QLKIGDFGCAR----
|||||||||..|..|..                  ..||.|.      .. |.| ||  .|.   |||||.||.||... |    ..|| ||| ..    
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ

-----------TAFIDSLNVGKTTVGSSYFK----APEIIEGLEYG----FEVDIFSLGVLLYKMLFNSYPFEGQSVQE----------------IYKKM
           ...... .  .|..|. ...    |||...| .|.    ...||.||||.|| |||. |||....  .                .|.. 
NNNCDTNQQQKMQIWKQ-QMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNI

QSVSIDFKKNG-----VVISNQMIDFLQ----RLLKFDRNDRITWLQVYQHPVI
.   |.|.|         .|.. .||..    ..|| . | |||. |. .|| .
KQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 13838.AA Ciliate-E2a 11-268 32 3.5e-58 169.88 In-house 1-275 (275) Show / Hide 
Range on Protein: 11-268
Range on HMM: 1-275/275
Sequence Identity: 32% (90 aa)

FLIDKEVLGKGAFATVVKGLDLKNNQHIACKIVSKQKLKENPTLDNLFAQEIQLQRQLKSPYIIQLYKVYSVDNYYMLMMEYCEGGDLEKYLQKNGPIPE
. . | ..|||.|. |..   ...... | |...| |. .. . .  | .||.. |||. | ||.|| ||  .|.| | |||||||.|........ . |
YKFIK-KIGKGNFGSVYLAQHKQTGKQFAMKKFIK-KMYQQKKGKEYFMNEINIMRQLDHPNIIKLYEVYEDENNYYLVMEYCEGGELYDKIKQCKRFFE

Q-KAIGFLMQVLA--GLREIHSHSIIHRDLKPQNIFIK---GN-----QLKIGDFGCARTAFIDSLNVGKTTVGSSYFKAPEIIEGLE------YGFEVD
  . |  .|| |   ||  .|.  |.||||||.||..|    |     ..|| ||| |. .  |. .. .. .|. .. |||..   |      |.  .|
EIQEICDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKIIDFGLATFIDKDEKKYMFQKCGTPGYVAPEVLNNKEVLKHKQYDTKCD

IFSLGVLLYKMLFNSYPFEGQSVQEIYKKMQSVSIDFKKNG--VVISNQMIDFLQRLLKFDRNDRITWLQVYQHPVI
..|.|| .| .|. . ||.|....|| ..     |||  .     .|.. .|.....|. | . |||  | ..||  
MWSCGVIFYILLCGKPPFKGKTYNEILQQNKKCKIDFNCPECWEKCSKECKDLMKKMLEKDPKKRITAQQALNHPWF
Kinase 13838.AA STE 12-268 20 6e-52 178.91 In-house 1-359 (359) Show / Hide 
Range on Protein: 12-268
Range on HMM: 1-359/359
Sequence Identity: 20% (74 aa)

LIDKEVLGKGAFATVVKGLDL------KNNQH---------IACKIVSKQK-------------LKENPTLDNLFAQEIQLQRQLK--SPYIIQLYKVYS
. . |..||||| ||.|...       |...          .| |......              . |..  . . .||.. ....  .|.|.. |  | 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

VD-------NYYMLMMEYCEGGDLEKYLQKN--------------GPIPEQKAIGFLMQVLAG-LREIHSHSIIHRDLKPQNIFIKGNQLKIGDFGCART
..       ..  . |||..|| |.. ....              ...||.  . .. |.| | |  .||| |||||.||.||..     |. |||..  
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL----VKLCDFGVCGQ

AFI---------------DSLNVGKTTVGSSYFKAPEIIEG------LEYGFEVDIFSLGVLLYKMLFNSYPF-EGQSVQEIYKKMQS------------
                  ..    .| ||.  . |||.|..       .|.. .|| ||| ..  |.   .|. ...  . .. ....            
LTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCI

---VSIDFKKNGV----------------VISNQMIDFLQRLLKFDRNDRITWLQVYQ--HPVI
    .  .. .                    |  ..||... |. | |.| |  |  .  || |
VNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 13838.AA CAMK-Unique 12-268 21 1.6e-47 154.83 In-house 1-363 (363) Show / Hide 
Range on Protein: 12-268
Range on HMM: 1-363/363
Sequence Identity: 21% (78 aa)

LIDKEVLGKGAFATVVKGLDLKNNQHIACKIVSK-----QKLKEN-----------PTLDNLFAQEIQLQRQLKSPYIIQLYKV----YSVDN-------
 .  ...|.|.|  | ...| ..    |||.| |      |.|..             .|. .  |.|. . .. | ||.|| .    .  ..       
YKMHRIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLI

--------YYMLMMEYCEGGDLEKYLQK--------------------NGPIPE--QKAIGFLMQVLAGLREIHSHSIIHRDLKPQNIFIKGN-------
        |. . ||||.|||| ...||                    .|.  |    ..    ..|  .   || .|.|||||. || .. .       
IKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHH

----------QLKIGDFGCARTAFIDSLN-VGKTTVGSSYFKAP--------------EIIEGLEYGFEV----DIFSLGVLLYKMLFNSYPFEGQSVQ-
           .|. ||| ..       . . .|..|.....||              |.|..  |.  .    || ||||..| ||. . ||....   
RDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDCECEDR

-------EIYKKMQSVSI---DFKKNGVV--ISNQMIDFLQRLLKFDRNDRITWLQVYQHPVI
       ||...  .  .   | |....   ||.. .||...... | . |..  . ..|. |
DYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI
Kinase 13838.AA PLK-Unclassified 13-155 27 1.2e-30 108.16 In-house 2-151 (264) Show / Hide 
Range on Protein: 13-155
Range on HMM: 2-151/264
Sequence Identity: 27% (42 aa)

IDKEVLGKGAFATVVKGLDLKNNQHIACKIVSKQKLKENPTLDNLFAQEIQLQRQLKSPYIIQLYKVYSVDNYYMLMMEYCEGGDLEKYLQKN-------
.  . ||||.|| ...  ...... .| ||. |. |. | .   |  .||... .|. . | . ...   . .  ...|||..|.|  |. .        
HRGHFLGKGGFAKCYQVKNIETKKIYAAKIIPKSSLTKNRARQKLI-SEIKIHKSLHHKNIVKFEHCFEDHENVYILLEYCPNGTLMEYIKRRNFQLFEK

GPIPEQKAIGFLMQVLAGLREIHSHSIIHRDLKPQNIFI-KGNQLKIGDFG
  . |  .  ...|.. .|  .|...|||||||. |||.   ...||.|||
KRLTEYEVKCYTYQIVQALKYLHQNRIIHRDLKLGNIFLNDNMEVKICDFG
Kinase 13838.AA Pkinase_Tyr 12-159 29 5.4e-20 68.33 Pfam 1-160 (270) Show / Hide 
Range on Protein: 12-159
Range on HMM: 1-160/270
Sequence Identity: 29% (47 aa)

LIDKEVLGKGAFATVVKGLDL----KNNQHIACKIVSKQKLKEN-PTLDNLFAQEIQLQRQL-KSPYIIQLYKVYS-VDNY--YMLMMEYCEGGDLEKYL
..  ..||.||| .|.||       ..... | |.. |..  .    .   | .|... .|| . | |..|| | .  .    ... |||...||| .||
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQN-CREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

QK----NGPIPEQKAIGFLMQVLAGLREIHSHSIIHRDLKPQNIFIK-GNQLKIGDFGCART
.|    ..|.. .  ... .|. .|.   .|. .|||||   |. .. .|. ||.||| ||.
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARD
Kinase 13838.AA TyrKc 12-266 23 3.7e-17 54.71 SMART 1-280 (280) Show / Hide 
Range on Protein: 12-266
Range on HMM: 1-280/280
Sequence Identity: 23% (69 aa)

LIDKEVLGKGAFATVVKGLDLKNNQHIACKIVSKQKLKENPTLDNLFAQEIQLQRQL--KSPYIIQLYKVYSVD-------NYYMLMMEYCEGGDLEKYL
.  ...|| ||| .|.||      .  | | . . .          | .|... ..|  . | |..|| | . .         .|. |||...||| .||
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

QKNGP-IPEQKAIGFLMQVLAGLREIHSHSIIHRDLKPQNIFIKGNQ-LKIGDFGCARTAFID-------SLNVGKTTVGSS-----YFKAPEIIEGLEY
.|..| .. .. . |  |. .| . .||. .|||||   |. .. |.  ||.||| .|    |       .  . |.. |.         ||| |   ..
RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

GFEVDIFSLGVLLYKML-FNSYPFEG-----QSVQEIYKKMQSVSIDFKKNG------VVISNQMIDFLQRLLKFDRNDRITWLQVYQHP
 .. |..| ||... .. .   | .|      | ||.... ..     .         |  .  | .  ..  ..| .|| |  ....  
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 13838.AA PLK-Unclassified 179-268 33 6.7e-14 48.11 In-house 174-264 (264) Show / Hide 
Range on Protein: 179-268
Range on HMM: 174-264/264
Sequence Identity: 33% (31 aa)

APEIIEGLE--YGFEVDIFSLGVLLYKMLFNSYPFEGQSVQEIYKKMQSVSIDFKKNGVVISNQMIDFLQRLLKFDRNDRITWLQVYQHPVI
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APEILDGKHQGHSYEVDCWSFGCILYTLLIGKPPFETKDVKQTYKKIKCNQYSFPEP-CHISDNAKDLIQHILNWNPDQRPTIDQIMMHPFY
Kinase 13838.AA Pkinase_Tyr 179-202 37 5.871096 0.48 Pfam 182-205 (270) Show / Hide 
Range on Protein: 179-202
Range on HMM: 182-205/270
Sequence Identity: 37% (9 aa)

APEIIEGLEYGFEVDIFSLGVLLY
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APECINYGKFTTKSDVWSFGVLMW