Gene 26810 (Tetrahymena)

26810

Species: Tetrahymena
Alias: 1165, n.26810, 26810, PreTt26810, 11.m00507, TTHERM_00146030
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: NEK

Sequence

Name Sequence Type Origin Length Description Download
26810.AA Protein None 928 None Fasta, JSON
26810.kin_dom Protein Kinase Domain None 250 None Fasta, JSON
26810.NA RNA None 1647 None Fasta, JSON

Protein domain

Protein domains of 26810.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 26810.AA NEK 18-267 41 5.70000000001e-135 454.7 In-house 1-279 (286) Show / Hide 
Range on Protein: 18-267
Range on HMM: 1-279/286
Sequence Identity: 41% (117 aa)

YEKVKLLGSGNQGKAYLCKHAQTNQQ-----FVIKQIQLSCMSDQEIQKQY-KEVSILKSLSHPNIIKYQDSFLFKK-NYLCIVMDYAE-GGDLEQR---
||..| .|.|..||.|.... .....     .|.|.|....||..| |. . .|| |||.| ||||.|| |||. .. |.|||||.|.| ||||.|.   
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

IIQAQKANTLFDCKTILKWFTQLCSAVRFIHNQ-----KIIHRDIKNSNIFLDSNDN----ILLGDFGISKKLQNPKDKAST-IIGTPYFMAPEICNQQP
| . ......|. ..|..||.|.|.|....|..     ||.||||| .||||..|.|    . .||||||| |.. .|.|.|  .||||.|.||.|...|
IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNKP

YTNKVDIWAIGIVLFRLVYL--KYPFEGF--EIFHLMLAISRG-QLK-FPQT--PSSPLKNLIQKLLQNDPNKRPSIEQ
|.||.|||..| ||. .. |  | |||.    . .|.. | .| | .  |..   |. |.|||...|| || .|||..|
YNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQ
Kinase 26810.AA NEK1 18-267 40 2e-102 346.58 In-house 1-269 (276) Show / Hide 
Range on Protein: 18-267
Range on HMM: 1-269/276
Sequence Identity: 40% (109 aa)

YEKVKLLGSGNQGKAYLCKHAQTNQQFVIKQIQLSCMSDQEIQKQYKEVSILKSLSHPNIIKYQDSFLFKKN-YLCIVMDYAEGGDLEQRIIQAQKANTL
|.. | .|.|. |||.| ||   .|..||| |....|...|...  .|| ||. . ||||.||..||    .  | |||.|..|||| |.| ..   . |
YHYIKQIGEGSFGKAWLVKHKEDGQHYVIKEINVMKMQEKEREESMNEVAILAKMKHPNIVKYKESFEENGCGILYIVMEYCDGGDLMQKINRQKRKGKL

FDCKTILKWFTQLCSAVRFIHNQKIIHRDIKNSNIFLD--SND---------------NILLGDFGISKKLQNPKDKASTIIGTPYFMAPEICNQQPYTN
|   .|. ||.|.| |. .|| .||.||||| .||||   .|.                . ||||||.. |... . |.| |||||   ||||. .||.|
FSEDQIMHWFCQICLALNHIHDRKILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGIARMLNHTMEYACTCIGTPYYLSPEICQNKPYNN

KVDIWAIGIVLFRLVYLKYPFEGFEIFHLMLAISRGQL-KFPQTPSSPLKNLIQKLLQNDPNKRPSIEQ
| |||. | ||  |. || |||.    .| | | .|   . |...|  |..|. .... .|  |||. |
KSDIWSLGCVLYELCTLKHPFEANNWKNLVLKICQGTYPPIPPHYSYELQSLVSQMFKRNPRHRPSVNQ
Kinase 26810.AA NEK8 18-267 35 3.5e-81 231.51 In-house 1-271 (278) Show / Hide 
Range on Protein: 18-267
Range on HMM: 1-271/278
Sequence Identity: 35% (97 aa)

YEKVKLLGSGNQGKAYLCKHAQTN--QQFVIKQIQLSCMSDQEIQKQYKEVSILKSLSHPNIIKYQDSFLFKKNYLCIVMDYAEGGDLEQRIIQAQKANT
||..  .| |  | . |.     .  .. ..||| .. ||  | |    |...|. | ||||| | |.|. . | | |.| ||.|| |.| .|| |..  
YERIRVVGRGAFGICWLYRRKEDQSHHLVIWKQINMHRMSEKERQMAQNEIQVLSMLQHPNIISYYDHFM-EDNTLMIEMEYADGGTLYQ-MIQHQQNKL

LFDCK----------------TILKWFTQLCSAVRFIHNQKIIHRDIKNSNIFLDSN-DNILLGDFGISKKLQNPKDKAST---IIGTPYFMAPEICNQQ
... .                .||  |.| ||||...|   | |||.|  |||..     . .|||||||.. | | ...|   ..|||| | ||.|  .
FEEERQLKQVNHCFNIYFNEQMILWYFFQMCSAVHHMHQHNILHRDLKTQNIFMTRHRMVVKIGDFGISKIM-NTKYHMQTTKTVVGTPYYMSPEMCEGK

PYTNKVDIWAIGIVLFRLVYLKYPFEGFEIFHLMLAISRG--QLKFPQTPSSPLKNLIQKLLQNDPNKRPSIEQ
|| .| |.||.| ||. .  ||  ||.     | . | ..  .   .   |. .. |.  .|| || .|||  |
PYNQKSDMWALGCVLYEMCCLKRAFEASNLPALVWKIMQCRAYEPISDHYSNEMRMLVHNCLQQDPEQRPSASQ
Kinase 26810.AA S_TKc 18-274 30 5e-81 276.41 SMART 1-231 (231) Show / Hide 
Range on Protein: 18-274
Range on HMM: 1-231/231
Sequence Identity: 30% (81 aa)

YEKVKLLGSGNQGKAYLCKHAQTNQQFVIKQIQLSCMSDQEIQKQYKEVSILKSLSHPNIIKYQDSFLFKKNYLCIVMDYAEG--GDLEQRIIQAQK--A
||.....|.|  || |.|.|  |.... ||.|          .. ..|..|||.  ||||.|. |.|    ..|..||.|..|  ||| ..| . ..   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

NTLFDCKTILKWFTQLCSAVRFIHNQKIIHRDIKNSNIFLDSNDNILLGDFGISKKLQNPKDKASTIIGTPYFMAPEICNQQPYTN-KVDIWAIGIVLFR
.  |.  .. ... |.|.|. ..|...|||||.| .||.||.  .| ..|||....|       .|..|||..||||..   .|.  |.|.|..|..|. 
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE

LVYLKYPFEGFEIFHLMLAISRGQLKFPQTPSSPLKNLIQKLLQNDPNKRPSIEQTRL-------NSCR
... . ||.  ... ..  |           |...|..|.|.|| ||.|||.. .              
MLCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 26810.AA Pkinase 18-267 28 1.4e-79 275.48 Pfam 1-286 (293) Show / Hide 
Range on Protein: 18-267
Range on HMM: 1-286/293
Sequence Identity: 28% (82 aa)

YEKVKLLGSGNQGKAYLCKHAQTNQQFVIKQIQLSCMSDQEIQKQYK--EVSILKSLSHPNIIKYQDSFLFKKNYLCIVMDYAEGG----DLEQRII-QA
|.... .|||. |. |.|.|  |......|.| ..  .... |   .  |..|.|.|.||||... |.|   |.....||.|.|||    ||  .|  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDYISTWR

QKANTLFDCKTILKWFTQLCSAVRFIHNQKIIHRDIKNSNIFLDSNDNI----LLGDFGISKKL-QNPKDKASTIIGTPYFMAPEICN-QQPYTNKVDIW
... . |. ... ....|..... ..|...|||||.| .||..|.|..|     ..|||..|..   ..  ..|. |||..||||... .|.|. |||.|
HGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMW

AIGIVLFRLVYLKYPFEGF------EIFHLMLAISRGQLKFPQTPS---------------------SPLKNLIQKLLQNDPNKRPSIEQ
..|..|. ..  . || |       .  ...  | ...|.|.   .                     ...| .| ..|. ||.|||..||
SCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQ
Kinase 26810.AA Ciliate-E2 18-267 26 3.8e-76 259.29 In-house 1-358 (365) Show / Hide 
Range on Protein: 18-267
Range on HMM: 1-358/365
Sequence Identity: 26% (97 aa)

YEKVKLLGSGNQGKAYLCKHAQTNQQF------------------VIKQIQLSCMSDQEIQKQYKEVSILK----------------SLSHPNIIKYQDS
|...|..|.||.|. |.||. ....||                   ||.. . .|. ..|. . .| .|..                .|.||||||. ..
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FLF-KKNYLCIVMDYAEGGDLEQRIIQA-QKANTL------FDCKTILKWFTQLCS---------------AVRFIHNQK-IIHRDIKNSNIFLDSNDNI
|   ..|.. .||.|..||||...|..  .| |        |..| |.. ..|...               |....|... ||||||| .||..     |
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

LLGDFGISKKLQNP----------K---------------------DKASTIIGTPYFMAPEICN---------QQPYTNKVDIWAIGIVLFRLVYLKYP
 . |||.|||....          |                     . . ||.|||..||||| |         |..|. |.|||..|..|..... |.|
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

FEGFEIFHLMLAISRGQLKFP------------------QTPSSPLKNLIQK----LLQNDPNKRPS-IEQ
|        .  |  ....||                  .  |   |.||.|    .|| ||.||.. .||
F--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQ
Kinase 26810.AA CAMK 23-267 22 5.1e-76 244.27 In-house 1-418 (425) Show / Hide 
Range on Protein: 23-267
Range on HMM: 1-418/425
Sequence Identity: 22% (93 aa)

LLGSGNQGKAYLCKHAQTN------------QQFVIKQIQLSCMS--------------------------DQEIQKQYKEVSILKSLS-------HPNI
 ||.|. || .||.| .|.            |.. || |  . ..                          ..  .. ..|..|.|.|.       ||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IKYQDSFL------------FKKN-------YLCIVM---DYAEGGDL--E-QRIIQAQKAN------------TLFDCKTILKWFTQLCSAVRFIHNQK
||  . .             . ..       ....||   .|..||.|  .    |.... .              |. .   ..| |.||||...|...
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IIHRDIKNSNIFLDSND-----------------NILLGDFGISKKLQN-----------------------PKDKASTIIGTPYFMA-PEICNQ-----
|.|||.|  || ||.|.                 || . ||| ..|..                        . .| .|  |||..|| ||. |.     
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

---------QPYTNKVDIWAIGIVLFRLVYLKYPFEGF-------------EIFHLMLAISRGQLKFPQTPSSP------------------------LK
         ..|. |.|.|..|..|. ..  ..||.|              ..  |.  | .|.  ||  . ||                         |
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

NLIQKLLQNDPNKRPSIEQ
.||.|.|| ||.||..|||
DLIRKMLQVDPEKRMTIEQ
Kinase 26810.AA CAMKL 18-274 31 2.1e-74 236.79 In-house 1-297 (297) Show / Hide 
Range on Protein: 18-274
Range on HMM: 1-297/297
Sequence Identity: 31% (94 aa)

YEKVKLLGSGNQGKAYLCKH-AQTNQQFVIKQIQLSCMS-DQEIQKQ------------YKEVSILKSLS---HPNIIKYQDSFLFKKN-----YLCIVM
|. .| || |. ||  |..|   |...  || |  . .. |. ..|             ..|..|.|.|.   ||||||  . .  ...     ....||
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

DYAEGGD--LEQRIIQAQKANTLFDCKTILKWFTQLCSAVRFIHNQKIIHRDIKNSNIFLDSND--NILLGDFGISKKLQN----PKDKASTIIGTPYFM
 |..||.  | ..|..  . .  .. .   . |.|..||| ..|...|.|||||  || ||.|.  || . ||| | . ..    | .| .|  |.| .|
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM

APEICNQ--QPYT-NKVDIWAIGIVLFRLVYLKYPFEGF--------EIFHLMLAISRGQLKFP--QTPSSPLKNLIQKLLQNDPNKRPSIEQTRLNSCR
||||..   .||   |||||..|..|. .|. ..||..          |  |.. | .|  ..|    .| ....||.|.|| .|.|||.|.| .     
APEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase 26810.AA Ciliate-E2-Unclassified 18-267 26 2.2e-68 233.52 In-house 1-345 (352) Show / Hide 
Range on Protein: 18-267
Range on HMM: 1-345/352
Sequence Identity: 26% (90 aa)

YEKVKLLGSGNQGKAYLCKHAQTNQQFVIKQIQLSCMSDQEIQKQY--------KEVSILK--------------SLSHPNIIKYQDSFLF-KKNYLCIV
|...| .|.|..|| |.|.| ... |. ....  . ...   |...        ||. ..|               |.||..... . . | .|....||
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

MDYAEGGDLEQRII-------------QAQKANTLFDCKTIL-----KWFTQLCSAVRFIHNQK-IIHRDIKNSNIFLDSND---NILLGDFGISKKLQN
|.|.|||||.| |              . .| .  |... ..     ..| |....  ..| .. ||||||| .||..|.|    .| . |||||||.|.
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ

P---------------KDKASTIIGTPYFM----APEICNQQPYTNK----VDIWAIGIVLFRLVYLKYPFEGFEIFH----------------LMLAIS
.               .....|..|||..|    |||.  .| | ..    .|||. |..|. ... .|||..                     |   | 
NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIK

RGQLKFPQTP-------SSPLK-----NLIQKLLQNDPNKRPSIEQ
 ....||  |       .||       .|.||.|...||||...||
QKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQ
Kinase 26810.AA NEK4 18-265 37 2.6e-67 229.91 In-house 1-248 (257) Show / Hide 
Range on Protein: 18-265
Range on HMM: 1-248/257
Sequence Identity: 37% (94 aa)

YEKVKLLGSGNQGKAYLCKHAQTNQQFVIKQIQLSCMSDQEIQKQYKEVSILKSLSHPNIIKYQDSFLFKKN-YLCIVMDYAEGGDLEQRIIQAQKANTL
|. .|  | |  |  .| .| .   |.|.| ..|   | .| .   .|. .|  | ||||..| .|.    . .|.||| . ||||| ..  . || | .
YCHMKVVGKGSYGEVWLVRHRRDKKQYVMKKMFLKNASRRERKAAEHEAQLLSQLKHPNIVEYKESWEIENGQFLYIVMGFCEGGDLYRK-LKQQK-NQF

FDCKTILKWFTQLCSAVRFIHNQKIIHRDIKNSNIFLDSNDNILLGDFGISKKLQNPKDKASTIIGTPYFMAPEICNQQPYTNKVDIWAIGIVLFRLVYL
 . . .. || |   |  ..| ..|.||| |  ||||     | .||||||. |.|  | |.|.|||||.| ||.   .||  | |||..|  .. .. |
LEEYQVVEWFVQIAMALQYMHEKHILHRDLKTQNIFLTKKNIIKIGDFGISRVLNNHCDMAKTMIGTPYYMSPECFGNRPYDYKSDIWSLGCCVYEMITL

KYPFEGFEIFHLMLAISRGQLK-FPQTPSSPLKNLIQKLLQNDPNKRPSI
|  |.  ..  |.  |  ||.   |.  |  |.||. ..|.  |.|||||
KHAFDAKDMNSLIYQIIQGQPPPMPPNYSQDLQNLVYQMLEKQPTKRPSI
Kinase 26810.AA ULK 18-267 26 2.2e-61 210.27 In-house 1-322 (329) Show / Hide 
Range on Protein: 18-267
Range on HMM: 1-322/329
Sequence Identity: 26% (87 aa)

YEKVKLLGSGNQGKAYLCKHAQT----NQQFVIKQIQLSCMSDQE--------IQKQYKEVSILKSLS--------HPNIIKYQDSFLFKK-NYLCIVMD
|.. . ||.|  || |  .. .|    |.....|.|... |. ..        .|   .|. |.| |         ||||.|. | |  .. |.. |.|.
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

YAEGGDLEQRIIQAQK------ANTLFDCKTILKWFTQLCSAVRFIHNQKIIHRDIKNSNIFLDSNDN------------ILLGDFGISKKLQNP---KD
| .|||||| | . .|       .  .  . ... | |.... ...| ..||||||| .|| .. ..             . ..||| .|...|.   ..
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

KASTII------GTPYFMAPEICN----QQPYTNK-VDIWAIGIVLFRLVYLKYPFEGFEIFHLM------L---------AISRGQLKFP-----QTPS
 . |        |||..|||.| .    |.||... .||| .|.... ..| |.||..  .. .       |         .|   .|.||     .. |
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQIS

SPLKNLIQKLLQNDPNKRPSIEQ
. .|.||...|| |...| |.|.
PECKDLIRRMLQYDEKDRISWEE
Kinase 26810.AA ULK 18-267 27 9.3e-61 208.16 In-house 1-317 (324) Show / Hide 
Range on Protein: 18-267
Range on HMM: 1-317/324
Sequence Identity: 27% (87 aa)

YEKVKLLGSGNQG-KAYLCKHAQT---NQQFVIKQIQLSCMSDQEIQ--------KQYKEVSILKSLS---HPN--IIKYQDSFLFKK-NYLCIVMDYAE
|.. . ||.|  | | |  .. .|   ||.. .|.|... |.... .        .. .|..|.| |    |||  |.|. | |  .  |...|.|.| .
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

GGDLEQRIIQAQK-----ANTLFDCKTILKWFTQLCSAVRFIHNQKIIHRDIKNSNIFLDSNDN------------ILLGDFGISKKLQNP---KDKAST
|||||| | . .|      .  .  . ... | |.|.. ...|...||||||| .|| .  ..             . ..||| .|...|.   ...  |
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

II------GTPYFMAPEICN----QQPYTNK-VDIWAIGIVLFRLVYLKYPFEG--FEIFHL-----------MLAISRGQLKFP-----QTPSSPLKNL
.       |||..|||.| .    |.||... .||| .|.... ..| ||||..   . ..            .. |   ...||     .  |. .|.|
CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSWFNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKDL

IQKLLQNDPNKRPSIEQ
|...|| |...| |.|.
IRRMLQYDEKDRISWEE
Kinase 26810.AA TyrKc 18-278 19 3e-16 39.98 SMART 1-280 (280) Show / Hide 
Range on Protein: 18-278
Range on HMM: 1-280/280
Sequence Identity: 19% (57 aa)

YEKVKLLGSGNQGKAYLCKHAQTNQQFVIKQIQLSCMSDQEIQKQYKEVSILKSL--SHPNIIKYQDSFLFKK------NYLCIVMDYAEGGDLEQRIIQ
 .. | ||.|. |. |...     .|  .| .. ..     ..  ..| .|...|  .||||..     . ..        |.||| |...||| ...  
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

AQKANTLFDCKTILKWFTQLCSAVRFIHNQKIIHRDIKNSNIFLDSNDNILLGDFGISKKLQNP-------KDKAS--TIIGT---PYF-MAPEICNQQP
 ..    .  |. |.. .| ..  ...| ...||||.   |. ...|  .  .||| |... .        . . .  .  |    |.  ||||  |   
HRPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

YTNKVDIWAIGIVLFRLVYL-KYPFEG-----FEIFHLMLAISRG-QLKFPQT--------PSSPLKNLIQKLLQNDPNKRPSIEQTRLNSCRQTRL
.| | |.|. |.... .  . . | .|      . ....  . .|  .. |.          .. . .....  . ||..||. ..         ..
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI------HECF
Kinase 26810.AA Pkinase_Tyr 18-172 21 9.5e-12 40.42 Pfam 1-163 (270) Show / Hide 
Range on Protein: 18-172
Range on HMM: 1-163/270
Sequence Identity: 21% (36 aa)

YEKVKLLGSGNQGKAYLCKHA----QTNQQFVIKQIQLSCMSDQE--IQKQYKEVSILKSL-SHPNIIKYQDSFLFKKNY--LCIVMDYAEGGDLEQRII
 .. | ||.|. |. |...      .|...  .| .     ....  ...  .|..|.|.| .||||...    . ..    ..||| |...|||     
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

QAQKANTLFDCKTILKWFTQLCSAVRFIHNQKIIHRDIKNSNIFLDSNDNILLGDFGISKKLQN
.    .  .. |..|.. .| ...  . .....||||.   |. ...|  .  .||| .. ..|
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYN