Gene 19380 (Tetrahymena)

19380

Species: Tetrahymena
Alias: 593, 28.m00339, 19380, 3691.m00156, TTHERM_00301840, PreTt19380
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: NEK

Sequence

Name Sequence Type Origin Length Description Download
19380.AA Protein None 776 None Fasta, JSON
19380.kin_dom Protein Kinase Domain None 259 None Fasta, JSON
19380.NA RNA None 2331 None Fasta, JSON

Protein domain

Protein domains of 19380.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 19380.AA NEK 195-453 45 1.1e-157 530.16 In-house 1-286 (286) Show / Hide 
Range on Protein: 195-453
Range on HMM: 1-286/286
Sequence Identity: 45% (131 aa)

FEILSKLGEGSFSTVYRVRRGKDGKE-----YALKRIKMMKLNEKERENAV-NEVRFLASINCRNIISYKQAIYDEGVNQLCVIMEYAE-GGDLARI---
.||. |.|.|||..||.||| .|||.     |..|.|.|....|||..||. |||| |..... ||..|. ....|. |.|| .|||.| ||||..    
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

IRHASKAGKYIEEDMIWSYAIQMTIGIKALHDL-----NILHRDLKAANVFLDKYQTR---AMLGDLNVSKKLQVNG--LLYT-QTGTPYYASPEVWKDK
| .  ..|||.||..|| . ||| ...| .||      .|||||.| .|.||.|  ..   . .||...| |.. ..  ..|| |.|||||.||||...|
IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGIS-KVLNHTTDMAYTTQVGTPYYMSPEVCQNK

PYNNKSDIWSLGCVIYEMCAL--KPPFKGK--DMEDLFKKVQRG-VYDPIPSH--FSKELNLFIAQLLRVNPEQRPNCDEILKFSVI
||||||||||||||.||||.|  |.||...  .|. |..|...|  |.|||||  .|..|. .| |.|...|||||.|..||... |
PYNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase 19380.AA NEK1 195-453 39 2.7e-89 302.95 In-house 1-276 (276) Show / Hide 
Range on Protein: 195-453
Range on HMM: 1-276/276
Sequence Identity: 39% (110 aa)

FEILSKLGEGSFSTVYRVRRGKDGKEYALKRIKMMKLNEKERENAVNEVRFLASINCRNIISYKQAIYDEGVNQLCVIMEYAEGGDLARIIRHASKAGKY
.......|||||  .. |..  ||..|..| |. ||  |||||...|||  ||     ||..|| .   .|   |  .|||..||||.. |  .   || 
YHYIKQIGEGSFGKAWLVKHKEDGQHYVIKEINVMKMQEKEREESMNEVAILAKMKHPNIVKYKESFEENGCGILYIVMEYCDGGDLMQKINRQKRKGKL

IEEDMIWSYAIQMTIGIKALHDLNILHRDLKAANVFLD--KYQT--------------RAMLGDLNVSKKLQVNGLLYTQT--GTPYYASPEVWKDKPYN
. ||.| .. .|. .. .  || .|||||.|. |.||   |                  . |||  ... |. . ..| .|  ||||| ||| .  ||||
FSEDQIMHWFCQICLALNHIHDRKILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGIARMLN-HTMEYACTCIGTPYYLSPEICQNKPYN

NKSDIWSLGCVIYEMCALKPPFKGKDMEDLFKKVQRGVYDPIPSHFSKELNLFIAQLLRVNPEQRPNCDEILKFSVI
||||||||||| || |.|| || .. .  |  |. .| | |||.|.|.||   ..|....||. ||    ||.   |
NKSDIWSLGCVLYELCTLKHPFEANNWKNLVLKICQGTYPPIPPHYSYELQSLVSQMFKRNPRHRPSVNQILERPFI
Kinase 19380.AA S_TKc 195-453 30 1e-86 295.33 SMART 1-231 (231) Show / Hide 
Range on Protein: 195-453
Range on HMM: 1-231/231
Sequence Identity: 30% (83 aa)

FEILSKLGEGSFSTVYRVRRGKDGKEYALKRIKMMKLNEKERENAVNEVRFLASINCRNIISYKQAIYDEGVNQLCVIMEYAEG--GDLARIIRHASKAG
.||| |.|.|.|..||..|  |.|...|.|.||         |.. .|.. | . .. ||. .. ...|   . |...|||..|  ||| ..|..  . |
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG

KY--IEEDMIWSYAIQMTIGIKALHDLNILHRDLKAANVFLDKYQTRAMLGDLNVSKKLQVNGLLYTQTGTPYYASPEVWKDKPYNN-KSDIWSLGCVIY
..  . | ....|. |.  ... .|...|.||||| .|..||.   . ...|  ....|      .|. |||.| .|||    .|.  |.|.||.||..|
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

EMCALKPPFKGKDMEDLFKKVQRGVYDPIPSHFSKELNLFIAQLLRVNPEQRPNCDEILK-------FSVI
||.. .|||   .|. .|||.            |.|.  || ..|...||.|| . |.|.          .
EMLCGYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 19380.AA NEK8 213-453 36 3.5e-72 205.34 In-house 19-278 (278) Show / Hide 
Range on Protein: 213-453
Range on HMM: 19-278/278
Sequence Identity: 36% (95 aa)

RRGKDG--KEYALKRIKMMKLNEKERENAVNEVRFLASINCRNIISYKQAIYDEGVNQLCVIMEYAEGGDLARIIRHASKAGKYIEED------------
||  |.  .   .| | |  . ||||  | ||.. |. ..  |||||     ..  |.|   ||||.|| |...| |  .. .  ||             
RRKEDQSHHLVIWKQINMHRMSEKERQMAQNEIQVLSMLQHPNIISYYDHFMED--NTLMIEMEYADGGTLYQMIQHQ-QNKLFEEERQLKQVNHCFNIY

----MIWSYAIQMTIGIKALHDLNILHRDLKAANVFLDKYQTRAMLGDLNVSKKLQVNGLLYT---QTGTPYYASPEVWKDKPYNNKSDIWSLGCVIYEM
    ||  | .|| ...  .|. |||||||| .|.|... ..   .||   ||..    . .|     ||||| |||  . ||||.|||.|.||||.|||
FNEQMILWYFFQMCSAVHHMHQHNILHRDLKTQNIFMTRHRMVVKIGDFGISKIMNTKYHMQTTKTVVGTPYYMSPEMCEGKPYNQKSDMWALGCVLYEM

CALKPPFKGKDMEDLFKKVQRG-VYDPIPSHFSKELNLFIAQLLRVNPEQRPNCDEILKFSVI
| ||  | .     |  |  ..  | ||..| |.|.   . ..| . |||||  ..|..   .
CCLKRAFEASNLPALVWKIMQCRAYEPISDHYSNEMRMLVHNCLQQDPEQRPSASQIMAMPLC
Kinase 19380.AA Pkinase 195-453 25 4.8e-72 250.47 Pfam 1-293 (293) Show / Hide 
Range on Protein: 195-453
Range on HMM: 1-293/293
Sequence Identity: 25% (78 aa)

FEILSKLGEGSFSTVYRVRRGKDGKEYALKRIKMMKLNEKERENAVN--EVRFLASINCRNIISYKQAIYDEGVNQLCVIMEYAEGG----DLARIIRHA
..|..|.|.|||..||. .. ..||..|.|.||  . ..........  |.. ....|. ||. .. . .|   . ....|||.|||    ||...|.  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYIST-

SKAGKYI--EEDMIWSYAIQMTIGIKALHDLNILHRDLKAANVFLDKYQTRA----MLGDLNVSKK--LQVNGLLYTQTGTPYYASPEVWK-DKPYNNKS
 .... .  .|. . .|. |.  |.. .|. .|.||||| .|...|  .        ..|  ..|.  .  |. ..| .|||.|..||| . ...|  |.
-WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKV

DIWSLGCVIYEMCALKPPFKGK----DMEDLFKKVQRGVYDPIPSHFS-----------------------KELNLFIAQLLRVNPEQRPNCDEILKFSV
|.||.||..|||.  .|||.|.    .  |  ....|  . |......                       .|.  ||  .|...|..||....||.   
DMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPW

I
.
F
Kinase 19380.AA CAMK 200-449 19 3.6e-66 211.94 In-house 1-421 (425) Show / Hide 
Range on Protein: 200-449
Range on HMM: 1-421/425
Sequence Identity: 19% (80 aa)

KLGEGSFSTVYRVRRGKDG------------KEYALKRIKMMKLN--------------------------EKERENAVNEVRFLAS-------INCRNI
.||.|||..|..... ...            ...| | |.  ||                           .| |.|  .|.. . .       .. .||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

ISYKQAIYDEG-----------------VNQLCVIM---EYAEGG----D-LARIIRHASKAG----------KYIEEDMIWSYAIQMTIGIKALHDLNI
|.  ... |.                   .... .|   ||..||    | . .|..| ..            ....|.    |  |.  ... .|..||
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

LHRDLKAANVFLDKYQ----------------TRAMLGDLNVSKKLQV------------------------NGLLYTQTGTPYYAS-PEVWKD------
 |||||  |. ||.                      . |   ..|..                         . ...|. |||.|.. ||| .       
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

--------KPYNNKSDIWSLGCVIYEMCALKPPFKGK-------------DMEDLFKKVQRGVYDPIPSHFSK-----------------------ELNL
        ..|. |.|.||.|.. | |   .||| |.             ....||.|...| || .|..||.                       |   
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

FIAQLLRVNPEQRPNCDEILK
.| ..|.|.||.|......|.
LIRKMLQVDPEKRMTIEQCLN
Kinase 19380.AA STE 195-453 24 5.5e-65 222.21 In-house 1-359 (359) Show / Hide 
Range on Protein: 195-453
Range on HMM: 1-359/359
Sequence Identity: 24% (91 aa)

FEILSKLGEGSFSTVYRVRRGK---------------DGKEYALKRIKMMKLN---------------EKERENAVNEVRFLASIN--CRNIISYKQAIY
.|...|.|.|.| |||. .. |                |. .| |.... . |               ..|...  .|....   |  . ||. |  . .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

DEG-----VNQLCVIMEYAEGGDLARIIRHASKAGK----------YIEEDMIWSYAIQMTIG-IKALHDLNILHRDLKAANVFLDKYQTRAMLGDLNVS
.||      ..|...||| .|| |  ||.|  . ||          ...|. |  .. |   |  . ||...| |||.|.||..|      . | |  |.
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL------VKLCDFGVC

KKLQ-----------------VNGLLYTQTGTPYYASPEVWK------DKPYNNKSDIWSLGCVIYEMCALKPPF-KGKDMEDLFKKVQR----------
..|.                   .  .| .||| . .||| .      ||.|. |.|||||||.| ||.  |||. ....|. .| . .           
GQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQL

----GVYDPIPS-------------------HFSKELNLFIAQLLRVNPEQRPNCDEILK--FSVI
    |   |.|.                   ..|.|.. ||.. |. .|..||. .. ||   . |
CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 19380.AA NEK4 195-453 34 9.9e-65 221.36 In-house 1-257 (257) Show / Hide 
Range on Protein: 195-453
Range on HMM: 1-257/257
Sequence Identity: 34% (89 aa)

FEILSKLGEGSFSTVYRVRRGKDGKEYALKRIKMMKLNEKERENAVNEVRFLASINCRNIISYKQAIYDEGVNQLCVIMEYAEGGDLARIIRHASKAGKY
....   | ||.  |. ||  .|.| | .|.... .   .||  |  |.. |      ||..||     |    |...| . ||||| |  .   . .. 
YCHMKVVGKGSYGEVWLVRHRRDKKQYVMKKMFLKNASRRERKAAEHEAQLLSQLKHPNIVEYKESWEIENGQFLYIVMGFCEGGDLYRKLKQ--QKNQF

IEEDMIWSYAIQMTIGIKALHDLNILHRDLKAANVFLDKYQTRAMLGDLNVSKKLQ-VNGLLYTQTGTPYYASPEVWKDKPYNNKSDIWSLGCVIYEMCA
.||  .    .|  ..   .|. .|||||||  |.|| |      .||. .|. |.    .  |  ||||| |||..  .||. ||||||||| .|||  
LEEYQVVEWFVQIAMALQYMHEKHILHRDLKTQNIFLTKKNI-IKIGDFGISRVLNNHCDMAKTMIGTPYYMSPECFGNRPYDYKSDIWSLGCCVYEMIT

LKPPFKGKDMEDLFKKVQRGVYDPIPSHFSKELNLFIAQLLRVNPEQRPNCDEILKFSVI
||  |  |||  |  ..  |   |.|  .|..|   . |.|   |..||   .|..   |
LKHAFDAKDMNSLIYQIIQGQPPPMPPNYSQDLQNLVYQMLEKQPTKRPSIFDIFQMPYI
Kinase 19380.AA NEK6 195-444 36 9e-59 191.96 In-house 1-252 (252) Show / Hide 
Range on Protein: 195-444
Range on HMM: 1-252/252
Sequence Identity: 36% (93 aa)

FEILSKLGEGSFSTVYRVRRGKDGKEYALKRIKMMKL-NEKERENAVNEVRFLASINCRNIISYKQAIYDEGVNQLCVIMEYAEGGDLARIIRHASKAGK
|.|  |.| | || ||| .   |.|. |||....  .  .| |.  . |.  | ..|  |.| | ..  ..  |.| ...| |. ||..|.|.|  | ..
FQIEKKIGKGQFSEVYRAQCLWDDKHVALKKVQIFEMMDAKARQDCIKEIDLLKQLNHPNVIKYYASFIEN--NELNIVLELADAGDMSRMIKHFKKQKR

YIEEDMIWSYAIQMTIGIKALHDLNILHRDLKAANVFLDKYQTRAMLGDLNVSKKLQVNGL-LYTQTGTPYYASPEVWKDKPYNNKSDIWSLGCVIYEMC
 | |  || | .|..  .. .|   ..|||.| ||||.   .    |||| . .    .        ||||| |||  ... || |||||||||..||| 
LIPERTIWKYFVQLCSALEHMHSKRVMHRDIKPANVFITA-NGIVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMA

ALKPPFKGKDME--DLFKKVQRGVYDPIPS-HFSKELNLFIAQLLRVNPEQRPNC
||. || |  |    | ||...  | |.|. |.|..|   ..  .  .||.||. 
ALQSPFYGDKMNLYSLCKKIEQCDYPPLPADHYSEQLRQLVCMCIHPDPEWRPDI
Kinase 19380.AA Ciliate-E2 195-453 21 1e-55 189.76 In-house 1-365 (365) Show / Hide 
Range on Protein: 195-453
Range on HMM: 1-365/365
Sequence Identity: 21% (80 aa)

FEILSKLGEGSFSTVYRVRR-----------------------GKDGKEYALKRIKMMKLNEKERENAVN-EVR----------FLASINCRNIISYKQA
.... |.|.|.|..||....                       . ..|.||.|..|  .......|. .. |..           | ..|. ||| .. .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

IYDEGVNQLCVIMEYAEGGDLARIIRHASK--------AGKYIEEDMIWSYAIQMT---------------IGIKALHDLN-ILHRDLKAANVFLDKYQT
 ...  | .  .|||..||||  .|.. .|        . ||. |  |  .  | .                ... ||  | |.|||.|  |...     
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

RAMLGDLNVSKKLQVN--------------------------------GLLYTQTGTPYYASPEVWKDKP---------YNNKSDIWSLGCVIYEMCALK
   . |.  |||.. .                                 . .|. |||.| .||. . |.         |. |.||||||...|||.  |
-IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGK

PPFKGKDMEDLFKKVQRGVYD-P----------------IPSHFSKELNLFIAQ----LLRVNPEQRPN-CDEILKFSVI
|||        ... . . .| |                .. . |.|   .| .    .| ..||.|..  ..||.   .
PPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 19380.AA ULK 195-453 25 1.4e-54 187.61 In-house 1-324 (324) Show / Hide 
Range on Protein: 195-453
Range on HMM: 1-324/324
Sequence Identity: 25% (82 aa)

FEILSKLGEGSFS-TVYRVRRGKD---GKEYALKRIKMMKLNEKERE--------NAVNEVRFLASIN------CRNIISYKQAIYDEGVNQLCVIMEYA
...  .||.|||  .||. |  |.   .. .| | | . |.|.|. |        .  ||.. .  ..      . .|. ..   ..   | .. |||| 
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNH-HIVKLYDWFETSNHNNIYIIMEYC

EGGDLARIIRHASK-----AGKYIEEDMIWSYAIQMTIGIKALHDLNILHRDLKAANVFLDKYQTR-----------AMLGDLNVSKKLQVNG----LLY
.||||  .|    |      .|...|. . .. .|   | |.||. || |||.| .|  . . |.            . ..|   .|... |.    ...
NGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQ

TQT------GTPYYASPEVWK----DKPYNNK-SDIWSLGCVIYEMCALKPPFKGKDMEDLF----KKVQRG------VYD-----PIPS---HFSKELN
|.       |||.| .|....     |||... .|||||||..|||   |.||..   .|..    | .. |      ...     |.|.   ..|.|. 
TCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECK

LFIAQLLRVNPEQRPNCDEILKFSVI
 .| ..| .....| . .||..  ..
DLIRRMLQYDEKDRISWEEIFNHPWF
Kinase 19380.AA NEK2 360-453 46 2.7e-47 157.24 In-house 226-319 (319) Show / Hide 
Range on Protein: 360-453
Range on HMM: 226-319/319
Sequence Identity: 46% (44 aa)

GTPYYASPEVWKDKPYNNKSDIWSLGCVIYEMCALKPPFKGKDMEDLFKKVQRGVYDPIPSHFSKELNLFIAQLLRVNPEQRPNCDEILKFSVI
||||| |||. .. .|| ||||||.||.|||||||.|||...    |  |.. | ...||.  |..||  |.  . |....||. .|||. . |
GTPYYMSPEQMHGQKYNEKSDIWSVGCLIYEMCALHPPFQATNQAQLQEKIKQGHFRRIPYQYSRHLNEIIHFMINVDHYHRPSIEEILQHPQI
Kinase 19380.AA NEK2 195-332 33 5.9e-33 108.23 In-house 1-159 (319) Show / Hide 
Range on Protein: 195-332
Range on HMM: 1-159/319
Sequence Identity: 33% (54 aa)

FEILSKLGEGSFSTVYRVRRGKDGKEYALKRIKMMKLNEKERENAVNEVRFLASINCRNIISYKQAIYDEGVNQLCVIMEYAEGGDLARIIRHASKAGKY
 |.|  .|.||| ... |||  |||  . | |.  ...|||.   |.|.  |      ||. |   | |.    | ..||| |||||. .| .. |  .|
YEVLYTIGNGSFGRCRKVRRKSDGKILVWKEICYGHMQEKECQMLVSECNILRQLKHPNIVRYYDWIIDRQNSTLYIVMEYCEGGDLSQMIKKCRKERQY

IEEDMIWSYAIQMTIGIKALHD------------------LN---ILHRDLKAANVFLD
.||  ||    |...  .  |                    .   |||||.| ||.|||
MEEEFIWRIMFQLCTALQECHNGVELPTLTTIYDRMKPRIDGKHTILHRDIKPANIFLD
Kinase 19380.AA TyrKc 195-451 22 4.4e-17 53.55 SMART 1-280 (280) Show / Hide 
Range on Protein: 195-451
Range on HMM: 1-280/280
Sequence Identity: 22% (65 aa)

FEILSKLGEGSFSTVYRVRRGKDGKEYALKRIKMMKLNEKERENAVNEVRFLASI--NCRNIISYKQAIYDEG-----VNQLCVIMEYAEGGDLARIIRH
 . . ||||| | .||. .      . | | .|  .     ||   .| | . ..  .  ||.    .. ..|     . .|...|||...|||   .| 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

ASKAGKYIEEDMIWSYAIQMTIGIKALHDLNILHRDLKAANVFLDKYQTRAMLGDLNVSKKLQVN------GLLYTQT---GTP-----YYASPEVWKDK
  .    .  .   |...|   |   ||. |. |||| | |. ... . ..  .|   |...         .  |...   |.         .||.....
HRPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG

PYNNKSDIWSLGCVIYEMCAL-KPPFKG-----KDMEDLFKKVQRGVYDPIPSH--------FSKELNLFIAQLLRVNPEQRPNCDEILKFS
 .. |||.|| | ...|.. . ..|  |     .. ......|..| . |.| .         ..|.   . |  . .||.||.  || .. 
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 19380.AA Pkinase_Tyr 195-333 25 2.9e-07 25.2 Pfam 1-146 (270) Show / Hide 
Range on Protein: 195-333
Range on HMM: 1-146/270
Sequence Identity: 25% (37 aa)

FEILSKLGEGSFSTVYRVRRG----KDGKEYALKRIKMMKLNEKE--RENAVNEVRFLASI-NCRNIISYKQAIYDEGVN-QLCVIMEYAEGGDLARIIR
 ... |||||.| .||. .      ... . | | .|  .  ...  ||   .|.. . .. .. ||...  ...|.|   |....|||...|||    |
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE-GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

HA-SKAGKYIEEDMIWSYAIQMTIGIKALHDLNILHRDLKAANVFLDK
   .  ..   .| . ....|   |   |.. |. |||| | |. ...
KHREDKQPLTMKD-LLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE
Kinase 19380.AA Pkinase_Tyr 366-413 25 2e-05 19.03 Pfam 182-232 (270) Show / Hide 
Range on Protein: 366-413
Range on HMM: 182-232/270
Sequence Identity: 25% (13 aa)

SPEVWKDKPYNNKSDIWSLGCVIYEMCAL-KPP-FKGKDMEDLFKKV-QRG
.||..... .. |||.|| | ...|.. . . | ..| . |...... ..|
APECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDG