Gene 4439 (Tetrahymena)

4439

Species: Tetrahymena
Alias: 128.m00117, PreTt04439, TTHERM_00773480, 3676.m00042, 684, 4439
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-E2
Subfamily: Ciliate-E2-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
4439.AA Protein None 726 None Fasta, JSON
4439.kin_dom Protein Kinase Domain None 255 None Fasta, JSON
4439.NA RNA None 2181 None Fasta, JSON

Protein domain

Protein domains of 4439.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 4439.AA AGC 345-599 26 1.2e-118 307.98 In-house 1-395 (395) Show / Hide 
Range on Protein: 345-599
Range on HMM: 1-395/395
Sequence Identity: 26% (107 aa)

FTYQYVIGKGGFGKVWRVEHK------KNQKPYAMKEMSKSK-IITKR--SVNSVMSE------------RHLLSQLK----------NPFLVN-MNYAF
|    |||||.||||. |..|       ..| |||| ..|.. |. |.   |  .|.|            |. |....          .||.|. . |.|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QDRDN--LYLVMDLVS---------GG-DLRFHI-G--RHRRFRENQTTCIMV-----------ALEYLHT-RNVIHRD-IKPENLVLDTDGYVKVTDLG
|| |.  ||.||....         || .| .|. |  . .|| |...  ..            ||||||  ...|||| .||||..|| ||..| || |
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

VARV--------------------------------------WKPEN--------------SQDTSG--TPGYMAPEVMCRQNHGIAVDYFA--VGVIAY
 . .                                      |. .|               .   |  || |||||.     .| |.|. .  .|.. |
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

EFMMGRRPYLGRN----------RKEIRDQILAKQ-VQIKKHEIP----------DGWSIEAADFINRMIQRKPMNRLGVN-------GPEEVKQHPWL
|.. |. |. | |          ..|. ..|.  . .. .| ..|          . .| || |.|...... | .||| .       | ||.|.||| 
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase 4439.AA Ciliate-E2-Unclassified 345-599 29 1.1e-110 374.0 In-house 1-352 (352) Show / Hide 
Range on Protein: 345-599
Range on HMM: 1-352/352
Sequence Identity: 29% (103 aa)

FTYQYVIGKGGFGKVWRVEHKKNQKPYAMKEMSKSKIITKRSVNSV---------MSERH-------------LLSQLKNPFLVNMNYAFQDRDNLYLVM
.. ...||.||||||....|||... ||||.|.|..|. .......         | ..              .|.....||.|.| |.|||..|.|.||
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM

DLVSGGDLRFHIG----------------RH-RRFRENQTT---------CIMVALEYLHTRN-VIHRDIKPENLVLDTDG---YVKVTDLGVAR-----
... ||||...|                 .. ..| |.|.          .| ..|||||  | .|||||||||...| .|   |.|..|.| ..     
EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQN

------------VWKPENSQDTSGTPGYM----APEVMCRQNHG----IAVDYFAVGVIAYEFMMGRRPYLGRNRKE----------------IRDQILA
            .||........|||.||    ||||...||..    ...|....|||.||...|..|. ..|...                ....|..
NNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQ

KQVQIKKHE---IPDGWSIEAADFINRMIQRKPMNRLGVN-GPEEVKQHPWL
|..|..|..   ||..|| ||.||||...|... .... . ..|....|||.
KNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 4439.AA Ciliate-E2 345-599 24 8.2e-92 311.32 In-house 1-365 (365) Show / Hide 
Range on Protein: 345-599
Range on HMM: 1-365/365
Sequence Identity: 24% (95 aa)

FTYQYVIGKGGFGKVWRVEHKKNQ-----------------------KPYAMKEMSKSKIITKRSVNSVM----------SERHLLSQLKNPFLVNMNYA
.  . .||.|.||.|......|.|                       | |||| |.|..|. . .....|           |. .|.||..|....| ..
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FQ--DRDNLYLVMDLVSGGDLRFHIG------------------RHRRFRENQTT------------CIMVALEYLHTRN-VIHRDIKPENLVLDTDGYV
||  |..|.||||....||||. .|                   .....   | .            ||..|||||| .| .|||||||||...     .
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KVTDLGVAR---------------VWKPENSQDT-------------------SGTPGYMAPEVMCRQN---------HGIAVDYFAVGVIAYEFMMGRR
|..|.| ..                |... ..||                    |||||||||.  ...         .. ..|....||| ||...|..
KIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP

PYLGRNRKEIRDQILAKQVQIKKHE-------------IPDGWSIEAADFINR----MIQRKPMNRLGVNGPEEVKQHPWL
|.         .||. ..... . |             ... || |. |.|..    |.|..| .|..  |.|....|||.
PF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRIT--GWEQILNHPWF
Kinase 4439.AA SGK 345-599 36 1.1e-90 280.3 In-house 1-283 (283) Show / Hide 
Range on Protein: 345-599
Range on HMM: 1-283/283
Sequence Identity: 36% (104 aa)

FTYQYVIGKGGFGKVWRVEHKKN------------------QKPYAMKEMSKSKII-------TKRSVNSVMSER-HLLSQLKNPFLVNMNYAFQDRDNL
| .  |||||.||||  |.||.                   .| ||||  .|  ||        | ... .|.||  .|. .| ||.||  ||||  . |
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

YLVMDLVSGGDLRFHIGRHRRFRENQ----TTCIMVALEYLHTRNVIHRDIKPENLVLDTDGYVKVTDLGVAR--VWKPENSQDTSGTPGYMAPEVMCRQ
|.||| | ||.. .|. | ..| | .    .  |  ||||||  ..|.|| ||||..|| .|... || | .   . . .      ||| |.||||.  |
YFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVLRKQ

NHGIAVDYFAVGVIAYEFMMGRRPYLGRNRKEIRDQILAKQVQIKKHEIPDGWSIEAADFINRMIQRKPMNRLGVN-GPEEVKQHPWL
 |. .|| .  | . ||.|.|  |.  ||...  |.|. .  ||..     . | .| | |.   |. | .||| . . .|.|.||. 
PHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPP-----QMSNDAWDLIQGLLQKDPKKRLGTKRDFMEIKNHPFF
Kinase 4439.AA Akt 345-599 38 2.5e-85 272.7 In-house 1-264 (264) Show / Hide 
Range on Protein: 345-599
Range on HMM: 1-264/264
Sequence Identity: 38% (102 aa)

FTYQYVIGKGGFGKVWRVEHKKNQKPY-AMKEMSKSKIITKRSVNSVMSERHLLSQLKNPFLVNMNYAFQDRDNLYLVMDLVSGGDLRFHIGRHRRFREN
|.. .|.||| ||||  |. |..|| | |||  .|..|| |. |  .. || .|   ..||.||..|.||. |.||.||| ..||.| .|. | ||| |.
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSED

QTTC----IMVALEYLHTRNVIHRD-IKPENLVLDTDGYVKVTDLGVAR--VWKP-ENSQDTSGTPGYMAPEVMCRQNHGIAVDYFA-VGVIAYEFMMGR
.. .    |. |.|.|| .|.| ||  ||||...| ||....|| | ..  . |  .  .   ||| |.|||.   . |. |||  . .|.. ||.| ||
RARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGR

RPYLGRNRKEIRDQILAKQVQIKKHEIPDGWSIEAADFINRMIQRKPMNRLG--VNGPEEVKQHPWL
 |.  .....  ..|. ..|....    | .| |. |.|... .. | .|||   |. .|.|.|||.
PPFYNQDHHQMFKKIKNQPVKFPDK---DWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase 4439.AA S_TKc 345-599 31 1.6e-80 274.7 SMART 1-231 (231) Show / Hide 
Range on Protein: 345-599
Range on HMM: 1-231/231
Sequence Identity: 31% (85 aa)

FTYQYVIGKGGFGKVWRVEHKKNQKPYAMKEMSKSKIITKRSVNSVMSERHLLSQLKNPFLVNMNYAFQDRDNLYLVMDLVSG--GDLRFHIGRHRR---
..   .||||.||||... ||| .. .|.|...          .....|. .|.. . |..|.. ..||| |.||.||....|  |||. .| ...|   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---FRENQTTCIMV----ALEYLHTRNVIHRDIKPENLVLDTDGYVKVTDLGVARVWKPENSQDTSGTPGYMAPEVMCRQNHGI-AVDYFAVGVIAYEFM
   | | .. ..|     ||||.| ...||||.||||. ||.   .|..| |.||.          ||| ||||||.    .|  ..|  ..|.| ||..
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEML

MGRRPYLGRNRKEIRDQILAKQVQIKKHEIPDGWSIEAADFINRMIQRKPMNRLGVNGPEE----VKQHPWL
 |. |.   . ... ..|.               | || |||... |. | .|...    .    .|.|||.
CGYPPFP--QMQMMFKKIG---------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 4439.AA AktR 345-599 35 1e-73 251.24 In-house 1-268 (268) Show / Hide 
Range on Protein: 345-599
Range on HMM: 1-268/268
Sequence Identity: 35% (97 aa)

FTYQYVIGKGGFGKVWRVEHK-KNQKPYAMKEMSKSKIITKRSVNSVMSERHLLS-QLKNPFLVNMNYAFQDRDNLYLVMDLVSGGDLRFHIGRHRRFRE
|..  ..|||.||||  |..| .||| ||||  .|.||| ..    .  ||  .  . ..||.|.. |.||....|...|. . ||.| .|. . ..| |
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

NQTTCIMVA----LEYLHTR-NVIHRDIKPENLVLDTDGYVKVTDLGVAR---VW-KPENSQDTSGTPGYMAPEVMCR-QNHGIAVDYFAVGVIAYEFMM
.|.  ...     ||||| . |.| ||.||||..|| ||.|| || | ..   .  . |  .   ||| |||||.  . . |. .||. |.|.  || ..
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVT

GRRPYLGRNRKEIRDQILAKQ-VQIKKHEIPDGWSIEAADFIN-RMIQRKPMNRLG--VNGPEEVKQHPWL
|  |    |.... . |. || ....... .   | .. |.|. .  .. | .|||   ||.||.| ||| 
GCPPFYHKNQNQMFQKIKIKQQNKFPYPSYF---SSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase 4439.AA RSK 350-599 35 3.8e-72 245.99 In-house 3-278 (278) Show / Hide 
Range on Protein: 350-599
Range on HMM: 3-278/278
Sequence Identity: 35% (98 aa)

VIGKGGFGKVW---RVEHKKNQKPYAMKEMSKSKIITK-RSVNSVMSERHLLSQLK-NPFLVNMNYAFQDRDNLYLVMDLVSGGDLRFHIGRHRR---FR
| |.||.|||    ...|..... ||||  .|.||... ...  .| ||  |.  .  ||.|. .||||. . |||.|....||.|  |. ....   | 
VLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGCFS

ENQTTCIM----VALEYLHTRNVIHRDIKPENLVLDT---DGYVKVTDLGVARVWKPENSQDTS---GTPGYMAPEVMC---RQN-HGIAVDYFAVGVIA
|.    .|    .|.|.||.. .||||.|||| ..|    .| .|.|| | ..  .....| |    .|  |||||.     .|. |. |.|..  ||. 
EDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGVLM

YEFMMGRRPYLG---RNRKEIRDQILAKQ--VQIKKHEIPDGWSIEAADFINRMIQRKPMNRLG--VNGPEEVKQHPWL
||  .|..|. |    ||||| ..|. ..  .   ......  | || |.|..| .| | .|||   .. ||.|||||.
YEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSL---TMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase 4439.AA CAMK 350-599 19 2.2e-68 219.2 In-house 1-425 (425) Show / Hide 
Range on Protein: 350-599
Range on HMM: 1-425/425
Sequence Identity: 19% (82 aa)

VIGKGGFGKVWRVEHKKNQ------------KPYAMKEMSKSKII-------------------------TKRSVNSVMSERHLLSQ-------LKNPFL
..|.|.|||| ...||...            . .|.| ..|.|.                          . ..  .|..| .....       |. | .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VNMNYAFQD-------------------RDNLYLVM---DLVSGGDL----------RFH----------IGRHRRFRENQ----TTCIMVALEYLHTRN
...  ...|                   ....|.||   ...|||.|          . .          . ...|| | .       |  |..|.| .|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIV-ERGRFTEREARRYFRQICSAVHYCHSHN

VIHRDIKPENLVLDTDG----------------Y-VKVTDLGVARVWKPEN-------------------------SQDTSGTPGYMA-PEVMCRQN---
..|||.||||. ||...                . .|..| | |.. .| .                          ..  |||.||| |||  ..    
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

-----------HGIAVDYFAVGVIAYEFMMGRRPYLGRNRKEIR--------DQILAKQVQIKKHE-IPDGWSI-----------------------EAA
           .| ..|  ..||| |    |. |. | ...||.        |. | ....  | . .|. .|.                       |. 
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

DFINRMIQRKPMNRLGVNGPEEVKQHPWL
|.|..| |. | .|. .   |....|||.
DLIRKMLQVDPEKRMTI---EQCLNHPWM
Kinase 4439.AA Pkinase 345-599 28 1.5e-67 235.52 Pfam 1-293 (293) Show / Hide 
Range on Protein: 345-599
Range on HMM: 1-293/293
Sequence Identity: 28% (86 aa)

FTYQYVIGKGGFGKVWRVEHKKNQKPYAMKEMSKSKIITKRSVNSVM-SERHLLSQLKNPFLVNMNYAFQDRDNLYLVMDLVSGG----DLRFHIG--RH
..   .||.|.||.|..  ||...| .|.|...|...  .  .. .  || ...  |. |. | . ..|.|.|..|.||... ||    ||  .|   ||
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

RRF--RENQTTCIMV----ALEYLHTRNVIHRDIKPENLVLDTDGYV----KVTDLGVAR---VWKPENSQDTSGTPGYMAPEVMC-RQNHGIAVDYFAV
..|   |..  ..|     .|||.| ...||||.||||. .| .|..    |..| |.|.     . .  ..  |||.||||||   .| .| .|| ...
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GVIAYEFMMGRRPYLGR------NRKEIRDQILAKQVQIKKHEIPD----------------GWSIEAADFINRMIQRKPMNRLGVNGPEEVKQHPWL
|.| ||.. || |. |.      . ... ..|. ...     .  .                 || |. |||.......|  |..   .|...||||.
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT---AEQILQHPWF
Kinase 4439.AA MAST 345-488 35 1.2e-46 140.15 In-house 1-151 (337) Show / Hide 
Range on Protein: 345-488
Range on HMM: 1-151/337
Sequence Identity: 35% (53 aa)

FTYQYVIGKGGFGKVWRVEHKKNQKPYAMKEMSKSKIITKRSVNSVMSERHLLSQLKNPFLVNMNYAFQD--RDNLYLVMDLVSGGDLRFHIGRHR-RFR
|    .|.||..|.|. |.|||  . .||| . .. .| |  |..|..||  |....||| |.| |.||   .. |..||. ..|||  ...     .. 
FEFIKCISKGAYGAVYLVKHKKTNDRFAMKVINCQDTIDKNQVDQVFVERNILTMYQNPFVVKMFYSFQTPCKKYLCMVMEYMEGGDCASLLRMYGNCMP

ENQTTCIM----VALEYLHTRNVIHRDIKPENLVLDTDGYVKVTDLGVARV
|. .  ..     .|||||    .|||.||.|...|..| .| || | . |
EWMAKMYIAETVLCLEYLHSYGIVHRDLKPDNMLIDSNGHIKLTDFGLSKV
Kinase 4439.AA MAST 345-482 38 1.5e-44 141.37 In-house 1-142 (334) Show / Hide 
Range on Protein: 345-482
Range on HMM: 1-142/334
Sequence Identity: 38% (55 aa)

FTYQYVIGKGGFGKVWRVEHKKNQKPYAMKEMSKSKIITKRSVNSVMSERHLLSQLKNPFLVNMNYAFQDRDNLYLVMDLVSGGDLRFHIGRHRRFRENQ
|.   .|.||..|||. |.|||  . .||| . ||  | |  |..|..||  |....||| |.| |.|| ...|..||. ..|||. ...    .| |. 
FEFIKPISKGAYGKVYLVKHKKTNDRFAMKVIKKSDMINKNMVDQVQVERNILAMYQNPFVVKMFYSFQTKNYLCMVMEYMEGGDCASLLHMYGYFDEWM

TTCIM----VALEYLHTRNVIHRDIKPENLVLDTDGYVKVTD
.  ..     .|||||    .|||.||.|...|..| .| ||
AKMYIAETVLCLEYLHSHGIVHRDLKPDNMLIDSNGHIKLTD
Kinase 4439.AA MAST 499-599 40 1.1e-28 89.29 In-house 226-334 (334) Show / Hide 
Range on Protein: 499-599
Range on HMM: 226-334/334
Sequence Identity: 40% (45 aa)

GTPGYMAPEVMCRQN-HGIAVDYFAVGVIAYEFMMGRRPYLGRNRKEIRDQILAKQVQIKK-HEIPDG--------WSIEAADFINRMIQRKPMNRLGVN
|||.|.||||  .|  ||..||....|.| |||. |  |  . .. || ..|| .        |.|.|         | || | |..  |  |  ||| |
GTPDYIAPEVILGQGTHGKPVDWWSMGIIMYEFLVGCPPFNDDTPEEIFQNILNRNC---NEIEWPEGGDINDDEAMSPEAQDLIEKLLQPDPRKRLGAN

-GPEEVKQHPWL
 | .|||||| .
NGADEVKQHPFF
Kinase 4439.AA MAST 499-599 38 1.2e-27 81.03 In-house 230-337 (337) Show / Hide 
Range on Protein: 499-599
Range on HMM: 230-337/337
Sequence Identity: 38% (43 aa)

GTPGYMAPEVMCRQN-HGIAVDYFAVGVIAYEFMMGRRPYLGRNRKE-IRDQILAKQVQIKKHEIPDG--------WSIEAADFINRMIQRKPMNRLGVN
||| |.||||  .|  .| .||....|.| |||  |  |  | .. | | ..|. ..  |   | |..         | || | |..  |  |  ||| |
GTPDYIAPEVILGQGTYGKPVDWWSMGIIMYEFLVGCPPFNGDTPEEMIFQNIINHDREI---EWPEEGDPNDDDCMSPEAQDLIKKLLQPNPKKRLGAN

GPEEVKQHPWL
| .|.||||  
GADEIKQHPFF
Kinase 4439.AA TyrKc 345-593 19 5.1e-14 3.93 SMART 1-280 (280) Show / Hide 
Range on Protein: 345-593
Range on HMM: 1-280/280
Sequence Identity: 19% (56 aa)

FTYQYVIGKGGFGKVWRVEHKKNQKPYAMKEMSKSKIITKRSVNSVMSERHLLSQL--KNPFLVNMNYAFQDR-------DNLYLVMDLVSGGDLRFHIG
 |   ..| | ||.|.. . |    . | | . ...      .   |.|  ....|  ..| .|..  .  .        . |..|| ....|||. .. 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

RHRR-FRENQTTCIMV----ALEYLHTRNVIHRDIKPENLVLDTDGYVKVTDLGVARVWKPE------NSQDTS----GTPG-----YMAPEVMCRQNHG
.||. .   .   ...      |||| .|.||||.   |  .. .. ||..| | .| .. .       .  ..    |. .      ||||..      
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

IAVDYFAVGVIAYE-FMMGRRPYLG-----RNRKEIRDQILAKQVQIKKHE--------IPDGWSIEAADFINR-MIQRKPMNRLGVNGPEEV
.. | .. ||  .| |  |  || |      . .|.. .. .     . ..         ||       .  ..   .|  .. .     |. 
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI----HECF
Kinase 4439.AA Pkinase_Tyr 345-487 24 2.7e-09 32.13 Pfam 1-159 (270) Show / Hide 
Range on Protein: 345-487
Range on HMM: 1-159/270
Sequence Identity: 24% (39 aa)

FTYQYVIGKGGFGKVWRVEHK----KNQKPYAMKEMSKSKIITKRS--VNSVMSERHLLSQL-KNPFLVNMNYAFQ-DRDN--LYLVMDLVSGGDLRFHI
 |   ..|.| ||.|.. . |    ... | | | . |    ...     . |.|  ...|| ..| .|..  .   ...   .|.|| .. .|||. . 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KE-GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

GRH----RRFRENQTTCIMV----ALEYLHTRNVIHRDIKPENLVLDTDGYVKVTDLGVAR
 .|    ...   .  .. .    ..|||. .| ||||.   |  .. .. ||..| | ||
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLAR