Gene 21621 (Tetrahymena)

21621

Species: Tetrahymena
Alias: TTHERM_00412030, 21621, 3714.m00134, PreTt21621, 406, 44.m00288
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: CAMKK
Subfamily: CAMKK-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
21621.AA Protein None 885 None Fasta, JSON
21621.kin_dom Protein Kinase Domain None 369 None Fasta, JSON
21621.NA RNA None 2658 None Fasta, JSON

Protein domain

Protein domains of 21621.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 21621.AA CAMKK-Unclassified 183-519 38 1.4e-211 696.05 In-house 2-392 (392) Show / Hide 
Range on Protein: 183-519
Range on HMM: 2-392/392
Sequence Identity: 38% (150 aa)

TLL--LGQGTFAKVKLAISSTTQ---KQSQLLKKTYTVINSEGKQVIKNAFQNLMR----------EISIMKLIWHPNAIKLYEIIQNRQNDKIYL--VM
..|  ||.|.|.|||||....|.   .|.|...|.........|..|.|.... |.          ||.|||..||||..||||.|....|||||.  ||
EFLDKLGRGSFGKVKLATRRYTTDDGVQKQFAIKVFKKQKLKKKKFIYNDNAFTMKMKNRLHLVQQEIAIMKKLWHPNICKLYEVIDDPDNDKIYMGQVM

EYASQGQLMDWDSKMNIFTRNN----YLFATNLTSPRSEFSLLNSQQSN-------------------------HQTYLQSPSLISIPQQQSISQYQKAC
||...||.|.||........|.    |.|.|........|. ....|..                         |..||...........|.......||
EYCQMGQIMSWDYWKQDYQPNDGEIEYFFQTQTEYKPDQFCCQYYNQNGKLHNRQNQKICLFSNQILEMKPYKMHEQYLKKYFRQCCKGLQYMHNFNQAC

LDIKSNIDEEDSVDEEQIRMIFRDIKPQNILISKCGM-----VKLSDFGISTIVGDEEEN-LQNQDGTYHFQPPEFFAKEVKTQNNSNYSFLPGTFNPLR
..|...|.|.|..|..| ..|.||||||||||.....     .|..|||||.|...|... |.|..|||.|..|||..||........||||||||||||
SYIIIYINEFDKIDHFQ-DIIHRDIKPQNILIDHEDNDKGEHFKIADFGISVIMEHEQQKKLKNNAGTYCFMAPEFWSKENFKYDYNDYSFLPGTFNPLR

KTYRIERICRLKQADVWALGVTLYALVYKRLPFYHNNLQQLFH-LIEKGNLVFPS--KPKISPGLQNLIQGMLEKDFEKRLTLEDIQKNFWV
|||||||||..|.||.|.||||.|..||..|||.|.|||.||| .|......||.  .|..|.....|||.|..|...||.|........|.
KTYRIERICFYKKADIWSLGVTFYCMVYHSLPFWHKNLQELFHQMICQKEINFPPQYHPHCSHEFKDLIQKMCDKNPKKRITIDQMLVHPWF
Kinase 21621.AA CAMKK 183-519 33 1e-176 565.87 In-house 2-396 (396) Show / Hide 
Range on Protein: 183-519
Range on HMM: 2-396/396
Sequence Identity: 33% (139 aa)

TLL--LGQGTFAKVKLAISSTTQKQSQLLKKTYTV----INSEGKQVIK-------------------NAFQNLMREISIMKLIWHPNAIKLYEIIQNRQ
.|.  .|||.|.|||||...... |..  .|....    .. ..||..                    |.|... .||.|||...||| .||||.|...|
ELMKEIGQGQFGKVKLAYNEYDT-QKHYAIKIFNKKYVFKKLKKKQQFYRDPPKRMTNMNQNGEMQMMNPFDCVYQEIAIMKKCNHPNIVKLYEVIDDPQ

NDKIYLV-MEYASQGQLMDWDSKMNIFTRNNYLFATNLTS----PRSEFSLLNSQQSN---------------HQTYLQSPSLISIPQQQSISQYQKACL
|||||.| |||...||.|.|.........|.....|.|.|    ....||....|||.               |..|.... ...|.... . .|||||.
NDKIYMVQMEYCERGQIMWWPYWKQDYQPNWPYQYTELYSNRQYQNKDFSIMSEQQSISEFINQVVKQDQYFIHEDYAWKYFRDCIKGLEYLHNYQKACS

DIKSNIDEEDSVDEEQIRMIFRDIKPQNILISKCG---MVKLSDFGISTIVGDEEENLQN-----------QDGTYHFQPPEFFAKEVKTQNNSNYSFLP
.|...|.|.. .|..| ..|.||||||||||...|   .||..|||.|.|.......|.|           ..||..|..||.. || ...|...|    
YIIIYINEFI-IDHFQ-DIIHRDIKPQNILIDEEGCGEHVKIADFGVSHIFEGQDQTLSNCESCFQRELNKTAGTPAFMAPELCSKENQKENYNGY----

GTFNPLRKTYRIERICRLKQADVWALGVTLYALVYKRLPFYHNNLQQLFH---LIEKGNLVFPS-----------KPKISPGLQNLIQGMLEKDFEKRLT
       | ||...|.. |.||.||||||||..|....||.||||.||.|    |.. ...||.            |.||..|..||..||||...||.|
-------K-YRFRFIYCGKAADIWALGVTLYCFVFGKCPFWHNNLMQLHHNYMKIKNDPIKFPENKEMLNNVSIYCPEISEDLKDLIKRMLEKNPTKRIT

LEDIQKNFWV
...|....||
IPQIKVHPWV
Kinase 21621.AA Ciliate-E2 180-519 18 2.6e-49 167.44 In-house 1-365 (365) Show / Hide 
Range on Protein: 180-519
Range on HMM: 1-365/365
Sequence Identity: 18% (85 aa)

KDETLLLGQGTFAKVKLAISSTTQKQSQLLKKTYTVINSEG-------------KQVIKNAFQNLMREISIMKLIW----------------HPNAIKLY
 .   ..|||.|..|...    .|||... ... . . . .             |...||  .....||.||. |                 ||| ||.|
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQ-QRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMY

EIIQNRQNDKIYLVMEYASQGQLMD-----WDSKMNIFTRNNYLFATNLTSPRSEFSLLNSQQSNHQTYLQSPSLISIPQQQSISQYQKACLDIKSNIDE
|  |. ....|||||||...| |.|     . .. ....                                                          . .
ECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIE----------------------------------------------------------K-D

EDSVDEEQIR---------------------------------MIFRDIKPQNILISKCGMVKLSDFGISTIVGDEEE-----NLQN-------------
  . .|..|.                                  | |||||.|||.     .|..|||.|... |...     ....             
-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPG

-------------QDGTYHFQPPEFFA-KEVKTQNNSNYSFLPGTFNPLRKTYRIERICRLKQADVWALGVTLYALVYKRLPFYHNNLQQLFHLIEKGNL
             . ||.....|| .  |.  .|                    ...    ...|.|.|||.|| ......||        .  |.....
YMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQ--------------------QKQKGYDYKCDIWSLGVILYEMLFGKPPF--------QQQIKQCKI

VFP----------------SKPKISPGLQNLIQG----MLEKDFEKRLT-LEDIQKNFWV
 ||                |. |.|.  ..||.     ||.|| |||.|  |.| .. | 
DFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 21621.AA CAMK 359-519 19 5.7e-41 129.28 In-house 203-425 (425) Show / Hide 
Range on Protein: 359-519
Range on HMM: 203-425/425
Sequence Identity: 19% (47 aa)

RDIKPQNILISKC-----------------GMVKLSDFGISTIVGD-----------------------EEENLQNQDGTYHFQP-PEFFAKEVKTQNNS
||.|| |||...                  . .|..||| .... .                       | . .. . || .. . || . .. . ..  
RDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQ-

NYSFLPGTFNPLRKTYRIERICRLKQADVWALGVTLYALVYKRLPFYHN-------------NLQQLFHLIEKGNLVFPSKP------------------
| .               |.    ...|.|..|| ||...  ..|||.              |...||. | ||.  ||...                  
N-A-T-----------DEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISD

----KISPGLQNLIQGMLEKDFEKRLTLEDIQKNFWV
    ..|.  ..||..||..| |||.|.|.. .  |.
EFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 21621.AA Ciliate-E2-Unclassified 357-519 24 2.9e-31 105.68 In-house 166-352 (352) Show / Hide 
Range on Protein: 357-519
Range on HMM: 166-352/352
Sequence Identity: 24% (51 aa)

IFRDIKPQNILISKCG---MVKLSDFGISTIVGDE---------------EENLQNQDGTYHFQ----PPEFFAKEVKTQNNSNYSFLPGTFNPLRKTYR
| |||||.|||... |    .|..|||||   ..                ..... . ||. ..    .|| . ..   .  .                 
IHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKA-----------------

IERICRLKQADVWALGVTLYALVYKRLPFYHNNLQQ----------------LFHLIEKGNLVFPSKP------KISPGLQNLIQ----GMLEKDFEKRL
       ...|.|.||| ||.... ..||| ||  |                |.  | ..|. ||. |      ..||  ...|.     ||.|. .||.
-------YKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRI

TLEDIQKNFWV
|.|.| .  | 
TFEQILNHPWF
Kinase 21621.AA Meta 444-519 38 2.3e-29 81.92 In-house 210-287 (287) Show / Hide 
Range on Protein: 444-519
Range on HMM: 210-287/287
Sequence Identity: 38% (30 aa)

ADVWALGVTLYALVYKRLPFYH--NNLQQLFHLIEKGNLVFPSKPKISPGLQNLIQGMLEKDFEKRLTLEDIQKNFWV
.||||.|||||..|. . ||    | .  |.  |    ..|| .|.||  |. .| .||.|. |.|... .|    ||
LDVWAMGVTLYCFVFGQCPFIDKTNYIMCLHDKIKNHPVMFPEQPEISEDLKDCIKRMLDKNPEHRIMIPEIKTHPWV
Kinase 21621.AA Pkinase 359-519 20 2.7e-28 101.13 Pfam 132-293 (293) Show / Hide 
Range on Protein: 359-519
Range on HMM: 132-293/293
Sequence Identity: 20% (40 aa)

RDIKPQNILISKCGMV----KLSDFGISTIV-GDEEENLQNQDGTYHFQPPEFFAKEVKTQNNSNYSFLPGTFNPLRKTYRIERICRLKQADVWALGVTL
||.||.||||.. | .    |..|||..  .     . ..   ||... .||                              ..    . .|.|..|..|
RDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR---------------------------GGQYYGPKVDMWSCGCIL

YALVYKRLPFYHN------NLQQLFHLIEKGNLVFPSKPKIS-------------------PGLQNLIQGMLEKDFEKRLTLEDIQKNFWV
| .. .|.||..       . .|.. .| .. | |..  ..|                   . .. .| ..|.|| .||.| |.| .  |.
YEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 21621.AA CAMKL 442-519 26 1.8e-27 84.58 In-house 215-297 (297) Show / Hide 
Range on Protein: 442-519
Range on HMM: 215-297/297
Sequence Identity: 26% (23 aa)

KQADVWALGVTLYALVYKRLPFY-------HNNLQQLFHLIEKGNLVFPSKP-KISPGLQNLIQGMLEKDFEKRLTLEDIQKNFWV
...|.|..||.|||.|. .|||         .. . ........   .| .. ..|  ...||..||... ||| |...| .  |.
PKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase 21621.AA CAMKL 186-276 35 5.7e-27 82.99 In-house 7-113 (297) Show / Hide 
Range on Protein: 186-276
Range on HMM: 7-113/297
Sequence Identity: 35% (40 aa)

LGQGTFAKVKLAIS-STTQKQSQLLKKTYTV--INSEGKQVIKNAFQN-----------LMREISIMKLIW---HPNAIKLYEIIQNRQN----DKIYLV
||.|.|.|||||.  .||       .. . .  |. .... . .. .|           . |||.|||..    ||| |||||.|.....    .|||||
LGKGSFGKVKLATHIRTT-------GEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLV

MEYASQGQ--LMDW
|||.| |   |.|.
MEYCSGGEMDLFDY
Kinase 21621.AA CAMK 185-276 24 1e-23 72.68 In-house 1-154 (425) Show / Hide 
Range on Protein: 185-276
Range on HMM: 1-154/425
Sequence Identity: 24% (38 aa)

LLGQGTFAKVKLAISS-TTQKQ---------SQLLKKTYTV----------------INSEGKQ-----VIKNAFQNLMREISIMKL-------IWHPNA
 ||.|.|.||||.|   ||.|.          .   | .                  |. ....     .  .  .|..|||.|||.       . ||| 
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IKLYEIIQNRQ-----------------NDKIYLVM---EYASQG----QLMDW
|||||......                 ....|.||   ||.| |     | |.
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDY
Kinase 21621.AA ULK 442-519 28 9e-23 76.38 In-house 235-329 (329) Show / Hide 
Range on Protein: 442-519
Range on HMM: 235-329/329
Sequence Identity: 28% (27 aa)

KQADVWALGVTLYALVYKRLPFYHNNLQQLF-----HL----------IEKGNLVFP---SKPKISPGLQNLIQGMLEKDFEKRLTLEDIQKNFWV
. .|.| ||. .| ..| . ||| .  ....      |          |.| .| ||   ..|.||| ...||..||..| ..| . |.. ...|.
YKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 21621.AA ULK 442-519 26 1.6e-22 76.8 In-house 231-324 (324) Show / Hide 
Range on Protein: 442-519
Range on HMM: 231-324/324
Sequence Identity: 26% (25 aa)

KQADVWALGVTLYALVYKRLPFYHNNLQQLFH--------------LIEKGNLVFP---SKPKISPGLQNLIQGMLEKDFEKRLTLEDIQKNFWV
. .|.| ||. .| ..| . ||. .  .....              .|.. .. ||   . ||||| ...||..||..| ..| . |.| ...|.
YKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKDLIRRMLQYDEKDRISWEEIFNHPWF
Kinase 21621.AA S_TKc 180-519 19 8.4e-20 73.02 SMART 1-231 (231) Show / Hide 
Range on Protein: 180-519
Range on HMM: 1-231/231
Sequence Identity: 19% (69 aa)

KDETLLLGQGTFAKVKLAISSTTQKQSQLLKKTYTVINSEGKQVIKNAFQNLMREISIMKLIWHPNAIKLYEIIQNRQNDKIYLVMEYASQ--GQLMDWD
 .   ..|.|.|.||....   |...   .|.                 ....|||.|.|   ||| .|||...|.   |..|.||||...  | |.|  
YEILRKIGKGAFGKVYKCRHKKTGRIV-AIKIIK---------------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYI

SKMNI------FTRNNYLFATNLTSPRSEFSLLNSQQSNHQTYLQSPSLISIPQQQSISQYQKACLDIKSNIDEEDSVDEEQIRMIFRDIKPQNILISKC
 |..       |.     | .          ...  .  |                                         . . | ||.||.|||... 
KKRGRHGLRFPFPE-HARFYM--------YQICCALEYCH-----------------------------------------SHGIIHRDLKPENILLDE-

GMVKLSDFGISTIVGDEEENLQNQDGTYHFQPPEFFAKEVKTQNNSNYSFLPGTFNPLRKTYRIERICRLKQADVWALGVTLYALVYKRLPFYHNNLQQL
  .|..|||.....         . || .. .|| .                                  . .|.|..|..|| ... . ||.  ..|..
-HIKICDFGLARQL-------TTFCGTPWYMAPEVL------------------------------GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMM

FHLIEKGNLVFPSKPKISPGLQNLIQGMLEKDFEKRLTLEDIQK-------NFWV
|..|             || . ..|...|.|| |||.|  .. .         |.
FKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 21621.AA MARK 221-276 45 1.6e-19 60.6 In-house 35-92 (262) Show / Hide 
Range on Protein: 221-276
Range on HMM: 35-92/262
Sequence Identity: 45% (27 aa)

KQVIK-NAFQNLMREISIMKLIWHPNAIKLYEIIQ--NRQNDKIYLVMEYASQGQLMDW
..  . ....|.||||.|||.. ||| |||...|.  ..|. .|||.||||| | |.|.
FKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQH-QIYLIMEYASGGELYDY
Kinase 21621.AA MARK 444-519 34 3.5e-18 56.21 In-house 187-262 (262) Show / Hide 
Range on Protein: 444-519
Range on HMM: 187-262/262
Sequence Identity: 34% (27 aa)

ADVWALGVTLYALVYKRLPFYHNN--LQQLFHLIEKGNLVFPSKPKISPGLQNLIQGMLEKDFEKRLTLEDIQKNFWV
.|.|.||| ||..|  ..||   .  . .|.  | .|.  .|..  .|....|||| .|  . |.| |.|.| |  |.
VDIWSLGVVLYFMVCGYFPFDGDTQDYKELYKKILRGKYDIPCH--VSKECRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase 21621.AA Meta 220-274 34 9e-14 36.08 In-house 58-112 (287) Show / Hide 
Range on Protein: 220-274
Range on HMM: 58-112/287
Sequence Identity: 34% (19 aa)

GKQVIKNAFQNLMREISIMKLIWHPNAIKLYEIIQNRQNDKIYLVMEYASQGQLM
|  . .|...   .|| |.|   ||| .||.|..   . | .|.|.||  .|  |
GCIQPRNPLDRVYQEIAILKKLDHPNVVKLVEVLDDPNEDYLYMVFEYVEKGPVM
Kinase 21621.AA ULK 186-275 29 9.6e-13 40.89 In-house 7-109 (329) Show / Hide 
Range on Protein: 186-275
Range on HMM: 7-109/329
Sequence Identity: 29% (31 aa)

LGQGTFAKVKLAISSTTQKQSQLLKKTYTVINSEGKQVIKNAFQN-------LMREISIMKLIW--------HPNAIKLYEIIQNRQNDKIYLVMEYASQ
||.|.|.||  ..   |. . .  .|    . .  |. .||  |.       |..|| ||| .         ||| .|||.. .. ... ||..|||  .
LGKGSFGKVYKGRNKKTK-D-YVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIMEYCNG

GQLMD
| |..
GDLEQ
Kinase 21621.AA Ciliate-E2-Unclassified 186-276 23 2.4e-11 35.63 In-house 7-111 (352) Show / Hide 
Range on Protein: 186-276
Range on HMM: 7-111/352
Sequence Identity: 23% (25 aa)

LGQGTFAKVKLAISSTTQKQSQLLKKTYTVINSEGKQV--IKNAFQNLMREISIMK--------------LIWHPNAIKLYEIIQNRQNDKIYLVMEYAS
.||| |.||.... . .. | . .|    ...   ||.   .  . | | |. ..|              |. ||. ...... . .. ..||.||||. 
IGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVMEYCE

QGQLMDW
.| |...
GGDLWQY
Kinase 21621.AA CAMKL 359-405 33 2.9e-11 32.07 In-house 151-203 (297) Show / Hide 
Range on Protein: 359-405
Range on HMM: 151-203/297
Sequence Identity: 33% (18 aa)

RDIKPQNILISKCG--MVKLSDFGISTIVGD----EEENLQNQDGTYHFQPPE
||||| |||... |   .|..||| |..  .    ... |  . |......||
RDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYMAPE
Kinase 21621.AA Pkinase 186-284 28 1.4e-09 34.97 Pfam 7-106 (293) Show / Hide 
Range on Protein: 186-284
Range on HMM: 7-106/293
Sequence Identity: 28% (31 aa)

LGQGTFAKVKLAISSTTQKQSQLLKKTYTVINSEGKQVIKNAFQNLMR--EISIMKLIWHPNAIKLYEIIQNRQNDKIYLVMEYASQG----QLMDWDS-
.|.|.|..|....   |.|       .. |   . .   ..  |.. |  ||.||| . ||| ..||.. ..  .|.||.||||.  |     |.|. | 
IGSGSFGCVYKCHHKGTGK-------IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYIST

-KMNIF--T
 . . |  .
WRHGCFYFS
Kinase 21621.AA ULK 357-405 28 2.3e-09 28.95 In-house 152-221 (329) Show / Hide 
Range on Protein: 357-405
Range on HMM: 152-221/329
Sequence Identity: 28% (20 aa)

IFRDIKPQNILISKC------------GMVKLSDFGISTIVGDE---EENLQNQD------GTYHFQPPE
| ||||||||||..             | .|..||| .  | ..   .. .. .       ||  .  |.
IHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQ
Kinase 21621.AA TyrKc 180-517 15 4.7e-09 -76.24 SMART 1-280 (280) Show / Hide 
Range on Protein: 180-517
Range on HMM: 1-280/280
Sequence Identity: 15% (58 aa)

KDETLLLGQGTFAKVKLAISSTTQKQSQLLKKTYTV---INSEGKQVIKNAFQNLMREISIMKLI--WHPNAIKLYEIIQNRQN-----DKIYLVMEYAS
      || | | .| ... .            ..|      |..       . .|||..||. .   ||| ..|| ..   .      . ...||||..
ITLGKKLGEGAFGEVYKGTWK------------IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMP

QGQLMDWDSKMNIFTRNNYLFATNLTSPRSEFSLLNSQQSNHQTYLQSPSLISIPQQQSISQ---------YQKACLDIKSNIDEEDSVDEEQIRMIFRD
 | | |   |                                         .. ..  |..           .|                    . | ||
HGDLKDYLRKHRPK-------------------------------------LCMKDLLSFCWQIACGMEYLHSK--------------------NCIHRD

IKPQNILISKCGMVKLSDFGISTIVGDE-------EENLQ----NQD--GTYHFQPPEFFAKEVKTQNNSNYSFLPGTFNPLRKTYRIERICRLKQADVW
.   |.|... . || |||| |  ..|.       .   .    . .    .   .|| .       | . ...                     . |||
LAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-------NYGKFTT---------------------KSDVW

ALGVTLY-ALVYKRLPFYH-----NNLQQLFHLIEKGNLVFPSKP-------KISPGLQNLIQGMLEKDFEKRLTLEDIQKNF
. ||...  . |   | .       . |........|.   . .          .. . ....   . | |.| | ..| . |
SFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 21621.AA ULK 357-393 36 6.1e-09 27.93 In-house 148-196 (324) Show / Hide 
Range on Protein: 357-393
Range on HMM: 148-196/324
Sequence Identity: 36% (18 aa)

IFRDIKPQNILISK------------CGMVKLSDFGISTIVGDEEENLQ
| ||||||||||..             | .|..||| . .| ..... |
IHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQ
Kinase 21621.AA ULK 186-271 28 6.4e-09 27.84 In-house 7-102 (324) Show / Hide 
Range on Protein: 186-271
Range on HMM: 7-102/324
Sequence Identity: 28% (29 aa)

LGQGTFA-KVKLAISSTTQKQSQLLKKTYTV--INSEGKQVIKNA------FQNLMREISIMKLIW---HPN--AIKLYEIIQNRQNDKIYLVMEYASQG
||.|.|. ||  ..   |..     .. . .  |.  . . .||        |.|..||.||| .    |||   .|||.. .. ... ||..|||  .|
LGKGSFGVKVYKGRNKKTNT----QNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCNGG
Kinase 21621.AA MARK 359-385 51 5.3e-08 22.44 In-house 128-156 (262) Show / Hide 
Range on Protein: 359-385
Range on HMM: 128-156/262
Sequence Identity: 51% (15 aa)

RDIKPQNILISKCG--MVKLSDFGISTIV
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RDIKPENILIDENGNHNIKIIDFGFSICI
Kinase 21621.AA Meta 357-382 57 1.3e-07 17.97 In-house 145-170 (287) Show / Hide 
Range on Protein: 357-382
Range on HMM: 145-170/287
Sequence Identity: 57% (15 aa)

IFRDIKPQNILISKCGMVKLSDFGIS
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IHRDIKPSNLLLNDDGHVKIADFGVS
Kinase 21621.AA MARK 186-205 45 0.000325 9.87 In-house 7-26 (262) Show / Hide 
Range on Protein: 186-205
Range on HMM: 7-26/262
Sequence Identity: 45% (9 aa)

LGQGTFAKVKLAISSTTQKQ
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IGHGSYAKVKLACHKHTGRK
Kinase 21621.AA Pkinase_Tyr 229-271 41 0.000369 14.71 Pfam 48-92 (270) Show / Hide 
Range on Protein: 229-271
Range on HMM: 48-92/270
Sequence Identity: 41% (19 aa)

QNLMREISIMKLI-WHPNAIKLYEIIQ-NRQ-NDKIYLVMEYASQG
. .|||..||| .  ||| ..|| ..   .. | .||.||||.  |
EDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN-QIYIVMEYMPHG
Kinase 21621.AA Pkinase_Tyr 365-398 22 0.562528 3.93 Pfam 141-174 (270) Show / Hide 
Range on Protein: 365-398
Range on HMM: 141-174/270
Sequence Identity: 22% (8 aa)

NILISKCGMVKLSDFGISTIVGDEEENL-QNQDGT
|.|... . || .||| .  .  ....  . ..|.
NCLVTENNVVKICDFGLARDI-YNDDYYYRKRGGG
Kinase 21621.AA Pkinase_Tyr 443-454 41 4.236632 0.96 Pfam 194-205 (270) Show / Hide 
Range on Protein: 443-454
Range on HMM: 194-205/270
Sequence Identity: 41% (5 aa)

QADVWALGVTLY
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KSDVWSFGVLMW