Gene 25157 (Tetrahymena)

25157

Species: Tetrahymena
Alias: 171.m00066, PreTt25157, TTHERM_00941510, 25157, 860
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Aur

Sequence

Name Sequence Type Origin Length Description Download
25157.AA Protein None 1378 None Fasta, JSON
25157.kin_dom Protein Kinase Domain None 253 None Fasta, JSON
25157.NA RNA None 4137 None Fasta, JSON

Protein domain

Protein domains of 25157.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 25157.AA Aur 1102-1354 48 7.79999999999e-209 557.56 In-house 1-257 (257) Show / Hide 
Range on Protein: 1102-1354
Range on HMM: 1-257/257
Sequence Identity: 48% (125 aa)

FKVGKKLGHGKFADVYVAVDKHTGFRVALKQIRKETIKEFNLYQDILNEIKVQGILSHPNIIKLYGFFIDNDSIYLIQELAIGKELFTELKSTIYKKFTE
|..||.||.||| .|| | .|.|.|..|||...||.||........ .|||.|  |.||||.|.||.|.|.. ||||.| | |.||..||.. ..|.|.|
FEIGKPLGKGKFGNVYLARHKKTHFIFALKVMFKEQIKKYCMEHQLRREIKIQSHLNHPNILKMYGYFHDDQRIYLILEYAPGGELYKELQKQPNKRFDE

NITAFYVRQVIEALIYMHSKNVVHRDLKPENIMVH--NGLLKICDFGYAAIVQKNKMRSTFCGTLDYVSPEMVQGKSYDFSVDVWSVGILTYELLIGHAP
...|.|..|...||.|.||||..|||.|||||...  || .||||||.... ..|..|.||||||||..||||.|...|..||.|..|.|.|||. |..|
QRAAKYMYQICNALDYCHSKNIIHRDIKPENILLDQCNGNIKICDFGWSVHCPNNNRRMTFCGTLDYMPPEMVEGQMHDHKVDIWCLGVLCYELCHGCPP

FAA-KSHDATFDQIL-NGELRFSGPISFEAGDFISRILEREPNSRMNLTQALQHPFI
|.. ..|| |.|.|. .....|. .||.|| |.||.||...|..||.| |...||.|
FESNENHDETYDRIKNKVDIQFPSHISKEAKDLISKILQHDPKQRMTLDQIMNHPWI
Kinase 25157.AA CAMK 1107-1354 23 8.8e-102 328.78 In-house 1-425 (425) Show / Hide 
Range on Protein: 1107-1354
Range on HMM: 1-425/425
Sequence Identity: 23% (99 aa)

KLGHGKFADVYVAVDKHTG------------FRVALKQIRKETIKEFN-------------------------LYQDILNEIKVQGILS-------HPNI
.||.| |. |. ...|.|.             .|| | | |. .|. .                           . ...||..   |.       ||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IKLYGFFID-------------------NDSIYLIQ---ELAIGKELFTELKSTIYKK-----------------FTENITAFYVRQVIEALIYMHSKNV
|||| .. |                   .. .|..    |.. | ||| .| . | ..                 |||  ...|.||...|. |.||.|.
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

VHRDLKPENIMV-HN-----------------GLLKICDFGYAAIVQK------------------------NKMRSTFCGTLDYVS-PEMVQGKS----
||||||||||.. .|                 . .||.||| |.....                        ... .|||||. |.. ||...||.    
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

----------YDFSVDVWSVGILTYELLIGHAPFAAK-------------SHDATFDQILNGELRFSGP----------------ISFE--------AGD
          |....|.||.|...| .| |. || ..             .   .| .|..|. .|  |                || |        . |
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

FISRILEREPNSRMNLTQALQHPFI
.|...|...|. ||...|.|.||..
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 25157.AA AGC 1102-1354 22 4.6e-99 256.14 In-house 1-395 (395) Show / Hide 
Range on Protein: 1102-1354
Range on HMM: 1-395/395
Sequence Identity: 22% (91 aa)

FKVGKKLGHGKFADVYVAVDKH------TGFRVALKQIRKET---IKEFNLYQDILNE------------IKVQGILS----------HPNIIK-LYGFF
|.. | .| | |  || . .|.      ||   |.| ..|..   ||. |  . ...|             ..   ..          ||.|.| |.  |
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

IDNDS--IYLIQELAI---------GK-ELFTELKST-IYKKFTENITAFYVRQ-------VIEALIYMHS-KNVVHRD-LKPENIMVHN-GLLKICDFG
 |.|   .|.. |...         |  |||. |.    ...|.|. . ||  .       .. || |.|| ....||| ||||||.  . | .|..|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

YAAIVQ---------------------------------------------------KNKMRSTFCG--TLDYVSPEMVQGKSYDFSVDVWS--VGILTY
 . ..                                                    |... .||||  | .|..||..    |....| ||  .|.| |
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

ELLIGHAPFAAKS----------HDATFDQIL------NGELRFSGP----------ISFEAGDFISRILEREPNSRMN----------LTQALQHPFI
|.|.|. || ...          .. .|..|.      | ...|  |          .| || |.|.. |...|. |              .  .||. 
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase 25157.AA S_TKc 1102-1354 34 2.3e-97 330.69 SMART 1-231 (231) Show / Hide 
Range on Protein: 1102-1354
Range on HMM: 1-231/231
Sequence Identity: 34% (93 aa)

FKVGKKLGHGKFADVYVAVDKHTGFRVALKQIRKETIKEFNLYQDILNEIKVQGILSHPNIIKLYGFFIDNDSIYLIQELAIG--KELFTELKSTIYKK-
.....|.|.| |. || ...|.|| .||.|.|.          ..|..||..     ||||.|||..| | |..|.. |.. |   .||. .|.  ... 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---FTENITAFYVRQVIEALIYMHSKNVVHRDLKPENIMVHNGLLKICDFGYAAIVQKNKMRSTFCGTLDYVSPEMVQGKSYDF-SVDVWSVGILTYELL
   |.|  ..||..|...|| |.||....|||||||||.. .  .|||||| |...      .|||||..|..||..   .|.. ..|.||.|.. ||.|
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEML

IGHAPFAAKSHDATFDQILNGELRFSGPISFEAGDFISRILEREPNSRMNLTQALQ-------HPFI
 |  ||    ....|..|.          | || |||...|...|. |.   .|||       ||..
CGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 25157.AA Pkinase 1102-1354 33 1.7e-92 318.4 Pfam 1-293 (293) Show / Hide 
Range on Protein: 1102-1354
Range on HMM: 1-293/293
Sequence Identity: 33% (99 aa)

FKVGKKLGHGKFADVYVAVDKHTGFRVALKQIRKETIKEFNLYQDIL-NEIKVQGILSHPNIIKLYGFFIDNDSIYLIQELAIGK----ELFTELK---S
...|.|.| | |. || ...| || .||.|.|.|...|.  ...... .||..   |.||||..||..| |.|.||...|.. |     .||. ..   .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

TIYKKFTENITAFYVRQVIEALIYMHSKNVVHRDLKPENIMVH-NGLL----KICDFGYAAI--VQKNKMRSTFCGTLDYVSPEMVQ-GKSYDFSVDVWS
. .  |.|.   ||..|....| |.||....|||||||||... || .    |||||| |.     .|   .|||||..|..|| .. |. |. .||.||
GCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

VGILTYELLIGHAPFAAK------SHDATFDQILNGELRFSGPIS---------------------FEAGDFISRILEREPNSRMNLTQALQHPFI
.|.. ||.| |. ||  .      .... ...|. ..|.|. | .                      |. |||...|.. |..| . .|.||||..
CGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 25157.AA CAMKL 1102-1354 30 3.7e-87 278.18 In-house 1-297 (297) Show / Hide 
Range on Protein: 1102-1354
Range on HMM: 1-297/297
Sequence Identity: 30% (92 aa)

FKVGKKLGHGKFADVYVAVD-KHTGFRVALKQIRKETIK-EFNLYQD-----------ILNEIKVQGILS---HPNIIKLYGFFIDNDS------IYLIQ
...|| ||.| |. |  |.. ..|| .|| | | |. |. . .  .            |  ||. .  |.   ||||||||  . . .       |||. 
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

ELAIGKE--LFTELKSTIYKK--FTENITAFYVRQVIEALIYMHSKNVVHRDLKPENIMVH-NG--LLKICDFGYAAIVQK-----NKMRSTFCGTLDYV
|.. | |  ||  ...  ...  ..|. . .| ||...|. |.||...||||.|||||..  ||   .||.||| ... ..     ... .||||.. | 
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM

SPEMVQG--KSYD-FSVDVWSVGILTYELLIGHAPFAAK--------SHDATFDQILNGELRFS--GPISFEAGDFISRILEREPNSRMNLTQALQHPFI
.||..||  |.|| . ||.|| |.. | .. |. || .          .   . .|  |  ..     .| .. |.|...|.. |. |... | ..||. 
APEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase 25157.AA CAMK1 1102-1354 35 3.9e-87 253.33 In-house 1-276 (276) Show / Hide 
Range on Protein: 1102-1354
Range on HMM: 1-276/276
Sequence Identity: 35% (100 aa)

FKVGKKLGHGKFADVYVAVDKHT---GFRVALKQIR-KETIKEFNLY--QDILNEIKVQG---ILSHPNIIKLYGFFIDNDSIYLIQELAIGKELF---T
...||..| | |..|| ...| |   |  .|.| |  |. .|. .    . ..||| .      ..||||||.| .. ... .||..||  | |||    
YEFGKEIGRGAFSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFDRIV

ELKSTIYKKFTENITAFYVRQVIEALIYMHSKNVVHRDLKPENIMVHNG----LLK--ICDFGYAAIVQKNK-MRSTFCGTLDYVSPEMVQG---KSYDF
| .     ..||.  .  ..|...|. |||||..|||||||||.   .      .|  |.||| . |.  .  . .| |||..|| ||.. .   | || 
EKG-----NYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVLECKKDKPYDK

SVDVWSVGILTYELLIGHAPFAAKS-HDATFDQILNGELRFSGP----ISFE-AGDFISRILEREPNSRMNLTQALQHPFI
..|.||.|. || || |. || ... ..  |..|...|..|  |    || . | |||.  || .|. | . .|.|.||.|
ACDMWSIGVITYILLCGYPPFYDENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI
Kinase 25157.AA Ciliate-E2 1102-1354 25 7.8e-85 288.15 In-house 1-365 (365) Show / Hide 
Range on Protein: 1102-1354
Range on HMM: 1-365/365
Sequence Identity: 25% (95 aa)

FKVGKKLGHGKFADVYVAVDKHTG-----------------------FRVALKQIRKETIKEFNLYQDILNEIK----------VQGILSHPNIIKLYGF
.|. ||.| | |..|| . .. ..                       . .|.|...|  |....  ..|..||.          .. .|.||||||.| .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FI--DNDSIYLIQELAIGKELFTELK----------------STIYKK-FTENITA-------FYVRQVIEALIYMHSKN-VVHRDLKPENIMVHNGLLK
|.  |...|||. |.. |..||  .|                .    | ... |.        ||....|.|| |.|||| ..|||.|||||..    .|
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----IK

ICDFGYAAIVQKN--------------------------------KMRSTFCGTLDYVSPEMVQGKS---------YDFSVDVWSVGILTYELLIGHAPF
|.|||.. .....                                 |  |.|||. |..||...||.         ||...|.||.|.. ||.| |  ||
IIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF

AAKSHDATFDQILNGELRFSGP------------------ISFEAGDFISR----ILEREPNSRMN-LTQALQHPFI
        ..||......|. |                  .| |. |.|..    .|...|. |..   |.|.||..
--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 25157.AA MARK 1102-1354 35 6.4e-84 274.2 In-house 1-262 (262) Show / Hide 
Range on Protein: 1102-1354
Range on HMM: 1-262/262
Sequence Identity: 35% (93 aa)

FKVGKKLGHGKFADVYVAVDKHTGFRVALKQIRKETIKEFNLYQDILNEIKVQGILSHPNIIKLYGFFI--DNDS-IYLIQELAIGKELFTELKSTIYKK
.|..| .||| .| |..|..|||| .||.| . |. . ...  . .  ||..   |.|||||||.  .   ..   |||| |.| |.||.  .|.    .
YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGR

FTENITAFYVRQVIEALIYMHSKNVVHRDLKPENIMV-HNG--LLKICDFGYAAIVQKNKMRSTFCGTLDYVSPEMVQGKSYD-FSVDVWSVGILTYELL
 .|. .  . ||...|. |.||||.||||.|||||.. .||    ||.|||...... ... .|||||. | .||....| || . ||.|| |.. | ..
LHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVLYFMV

IGHAPFAAKS--HDATFDQILNGELRFSGPISFEAGDFISRILEREPNSRMNLTQALQHPFI
 |. || ...      . .||.|. ..   .| |. ..|.|.|   |. |. ... ..||..
CGYFPFDGDTQDYKELYKKILRGKYDIPCHVSKECRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase 25157.AA CAMK-Unique 1102-1354 26 6.4e-77 253.42 In-house 1-363 (363) Show / Hide 
Range on Protein: 1102-1354
Range on HMM: 1-363/363
Sequence Identity: 26% (95 aa)

FKVGKKLGHGKFADVYVAVDKHTGFRVALKQIRKETIKEFNLYQ-----------------DILNEIKVQGILSHPNIIKLYGF----FIDND-------
 | .. .||| |  || . |..||   | | ..|.| ..  ..|                    .|. .   ..||||||||..    | | .       
YKMHRIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLI

--------SIYLIQELAIGKELFTELKS------------------TIYKKFTE--NITAFYVRQVIEALIYMHSKNVVHRDLKPENIMVHNG-------
         .|...|.. |..|| .. .                   .  .|.|  . |.|..... .|. ||||...||||||.||||| .        
IKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHH

----------LLKICDFGYAAIVQKNKMRS---TFCGTLDYVSP--------------EMVQGKSYDFSV----DVWSVGILTYELLIGHAPFAAKSHD-
           .|.|||| .. .. |||..   |.|||..|..|              |.. .  ||  .    | || | ..|..| |  ||.. . | 
RDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDCECEDR

-------ATFDQILNGEL-RF-----SGP--ISFEAGDFISRILEREPNSRMNLTQALQHPFI
        .|. |. |.. .|     .||  || || ||. . ....|..| .. ..|.|..|
DYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI
Kinase 25157.AA Ciliate-E2-Unclassified 1102-1354 25 1.8e-73 250.39 In-house 1-352 (352) Show / Hide 
Range on Protein: 1102-1354
Range on HMM: 1-352/352
Sequence Identity: 25% (89 aa)

FKVGKKLGHGKFADVYVAVDKHTGFRV------ALKQIRKETIKEFNLYQDILNEIKVQGI----------------LSHPNIIKLYGFFIDNDS--IYL
.|..|..|.| |..|| ...| ..  .        .||.|  .....  . ..... .. .                |.||...... |....|   ||.
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI

IQELAIGKELFTELKSTIY---------------KKFTENITA-----FYVRQVIEALIYMHSKN-VVHRDLKPENIMVHNG----LLKICDFGYAAIVQ
. |.. |..|.  .|.                  |.|||. ..     || .|....| |.|.|| ..|||.|||||...|.     .||.||| .   |
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ

KN----------------KMRSTFCGTLDYV----SPEMVQGKSYD----FSVDVWSVGILTYELLIGHAPFAAKSHDA----------------TFDQI
.|                .| .|||||. |     .||. ||. ||    ...|.||.|.. ||.| |  || ... .                  ...|
QNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNI

LNGELRFSG--------PISFEAGDFIS----RILEREPNSRMNLTQALQHPFI
..... |.          .|.|| |||.    ..|.  ||.|... |.|.||..
KQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 25157.AA RSK 1102-1354 29 3.9e-73 249.3 In-house 1-278 (278) Show / Hide 
Range on Protein: 1102-1354
Range on HMM: 1-278/278
Sequence Identity: 29% (83 aa)

FKVGKKLGHGKFADVYVAVDKHTGFRVALKQIRKETIKEFNL-YQDILNEIKVQGILS-HPNIIKLYGFFIDNDSIYLIQELAIGKELFTELKSTIYK-K
 ||  ..| ||.  .   ... ||   | |...| .|.  .    . . |...      ||.|..|.  | ... .||| |.  | |||| |.   ..  
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FTENITAFYVRQVIEALIYMHSKNVVHRDLKPENIMVHN----GLLKICDFGYAAI-VQK-NKMRSTFCGTLDYVSPEMVQ---GKS-YDFSVDVWSVGI
|.|.  .|| .... |. ..|.. ..|||||||||. ..    | .|..||| . . . . |..  |||.|..|. |||.    ... .| ..|.|| |.
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

LTYELLIGHAPFAA---KSHDATFDQILNGELRFSGP----ISFEAGDFISRILEREPNSRMN-----LTQALQHPFI
| ||.| |. ||..   .... ....|..|.. ...|    .| || |.|.. |.|.|. | .     . . .|||..
LMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase 25157.AA TyrKc 1102-1354 21 4.2e-16 37.7 SMART 1-280 (280) Show / Hide 
Range on Protein: 1102-1354
Range on HMM: 1-280/280
Sequence Identity: 21% (63 aa)

FKVGKKLGHGKFADVYVAVDKHTGFRVALKQIRKETIKEFNLYQDILNEIKVQGIL--SHPNIIKLYGFFIDN-------DSIYLIQELAIGKELFTELK
 . |||||.| |  || .. |     || | .....       .|...|...   |  .||||..|||  ..        . .... |.. .  |   |.
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

STIYKKFTENITAFYVRQVIEALIYMHSKNVVHRDLKPENIMVHNGL-LKICDFGYAAIVQKN--------KMRSTF--CGT----LDYVSPEMVQGKSY
..  | ..      .  |. .   | ||||..||||   |..|....  ||.||| .  .             |..   .|     .   .||  . . .
KHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

DFSVDVWSVGILTYELL-IGHAPFAA-----KSHDATFDQILNGELRFSGPI---------SFEAGDFISRILEREPNSRMNLTQALQHPFI
 .  |||| |.. .|..  |  |        .| .  . .. .|. .   |          . |  . ...  ...|..| . ..   | ..
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase 25157.AA Pkinase_Tyr 1102-1182 32 1.9e-12 42.81 Pfam 1-89 (270) Show / Hide 
Range on Protein: 1102-1182
Range on HMM: 1-89/270
Sequence Identity: 32% (29 aa)

FKVGKKLGHGKFADVYVAVDK----HTGFRVALKQIRKETIKE-FNLYQDILNEIKVQGIL-SHPNIIKLYGFFI-DNDS--IYLIQELA
 . |||||.| | .|| .. |     |.  || | ..  . .|   . .| ..|.|.   | .||||..|||  . . ..  ||.. |..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQN-CREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYM
Kinase 25157.AA Pkinase_Tyr 1207-1246 43 3.8e-05 18.06 Pfam 116-156 (270) Show / Hide 
Range on Protein: 1207-1246
Range on HMM: 116-156/270
Sequence Identity: 43% (18 aa)

YVRQVIEALIYMHSKNVVHRDLKPENIMVH-NGLLKICDFG
. .|. ... | .||| .||||   |..|. |.  ||||||
MCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFG