Gene 5825 (Tetrahymena)

5825

Species: Tetrahymena
Alias: PreTt05825, 5825, 3733.m00092, TTHERM_00579320, 328, 78.m00197
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: CMGC
Family: GSK

Sequence

Name Sequence Type Origin Length Description Download
5825.AA Protein None 449 None Fasta, JSON
5825.NA RNA None 1350 None Fasta, JSON
5825.kin_dom Protein Kinase Domain None 287 None Fasta, JSON

Protein domain

Protein domains of 5825.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 5825.AA GSK 49-335 52 1.8e-212 656.03 In-house 1-328 (328) Show / Hide 
Range on Protein: 49-335
Range on HMM: 1-328/328
Sequence Identity: 52% (172 aa)

ITLDKIIGNGTFGVVYLAKMN----DTQEQ----VAIKKVFQDKRYK-NREFEIIKSL---NHQNLIKLKQAYYTTQNNNPD-EVYLN-IVMEYVPETLS
.. .| ||.|.||||| |.||    .|.|.    ||||||.|||||| |||..|.| |   .|.|...||...|. .... . .||.| .||||.|.||.
YEEMKVIGHGSFGVVYQAYMNSPSNETKEIWLGPVAIKKVWQDKRYKCNRELQIMKMLGKLDHPNIVRLKYFFYMHYEKKDENHVYCNCLVMEYMPQTLY

KVIRTYRKSKQPFPPLLLKVFSYQMFRALAYLKGIGICHRDIKPQNILCDQKTMQLKICDFGSAKKLIK--GEPNVSYICSRYYRAPELIFGAEQYTTAI
.||| |.|.||..| ...|...|||||.|||| ..|||||||||||||.|..|..||||||||||.|..  .|||.||||||||||||||||...||..|
QVIRHYVKNKQQMPIIHIKLYMYQMFRGLAYLHSHGICHRDIKPQNILVDPDTGVLKICDFGSAKQLEPNKNEPNISYICSRYYRAPELIFGCTNYTCQI

DTWSIGTVIAEMILGEPLFPGENAVEQLVEIIKILGTPTKEQVQKMNPQHNQFNFP-----SIKPTSWTK-------------------IFAKQKPDP-M
|.||.|.|.|||..|.|||||...| |||||||.||||||||.|.|||....|.||      |||..|.|                   .| ....|. .
DVWSCGCVMAEMLKGQPLFPGDSSVDQLVEIIKMLGTPTKEQIQSMNPSYPEFKFPYWSFQQIKPHPWQKNDTKYEYQTYYHKKYRTVYMFKWCHTDMQD

LIDLISRLLVFVPTDRPTPLETLLHPYF
.|||||..||. |. |..||| ..||.|
WIDLISKCLVYDPKKRLSPLEACAHPFF
Kinase 5825.AA CMGC 49-335 22 2.7e-121 400.63 In-house 1-513 (513) Show / Hide 
Range on Protein: 49-335
Range on HMM: 1-513/513
Sequence Identity: 22% (115 aa)

ITLDKIIGNGTFGVVYLAKM--------------NDTQEQVAIKKVFQDKRYKN----------------REFEIIKSLN-----------------HQN
 . .| || ||.|||| ..               ..|.|.|||||..... |..                || .| | ||                 | |
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

LIKLKQAYYTTQNNNPDEV----------YLNIVMEYVPETLSKVIRTYRK-----SKQPFPPLL------------LKVFS------YQMFRALA--YL
..||.  .|. .......           .|..|.||.. .| ..|. ...      ..|...               | |.      ||..|.|.  |.
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

KGIG--ICHRDIKPQNILCDQKT-------------------MQLKICDFGSAKKLIKG----------------------EPNVSYICSRYYRAPELIF
   .  |.|||.||.||| ....                   ..|||||||.|... .                       .|. .|...|.|||||...
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILL

GAEQYT---------TAIDTWSIGTVIAEMILG--------EPLFPGENA-----------VEQLVEIIKILGTPT---------------KEQVQKMNP
|...||         |.|| ||.| ..|||..|        .|||||..            ..|| .|.|.|||||               .|.  .|..
GWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIK

QHNQFN---------------------------FPSIKPTSWTKIFAKQK---------------------------------PDPMLIDLISRLLVFVP
  . ..                           || ..| .|...| ...                                  || .|||....|.. |
LPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDP

TDRPTPLETLLHPYF
..|.|. . | ||||
DKRITAEQALQHPYF
Kinase 5825.AA Pkinase 49-335 29 9.9e-89 305.88 Pfam 1-293 (293) Show / Hide 
Range on Protein: 49-335
Range on HMM: 1-293/293
Sequence Identity: 29% (91 aa)

ITLDKIIGNGTFGVVYLAKMNDTQEQVAIKKVFQDKRYKNR--------EFEIIKSLNHQNLIKLKQAYYTTQNNNPDEVYLNIVMEYVPETLSKVIRTY
... ..|| |.||.||...  .|...||.|..  ... ..         | .| |.||| | ..|. ....     .|..|  .||||.. .|. |.  .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-----KDHIY--MVMEYCEGGLY-VMDLF

----RKSKQPF--PPLLLKVFSYQMFRALAYLKGIGICHRDIKPQNILCDQKTMQL----KICDFGSAKK--LIKGEPNVSYICSRYYRAPELIFGAEQY
    .... .|  ..  .| . ||..|.|.|.   ||.|||.||.|||.| .....    ||||||.||.  . ... . .. ....|.|||.| |.. |
DYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYY

TTAIDTWSIGTVIAEMILGEPLFPGE----NAVEQLVEIIKILGTPTKEQVQKMNPQHNQFNFPSIKPTSWTKIFAKQKPDPMLIDLISRLLVFVPTDRP
....| ||.| ...||..|.|.|||.    | ..|.. | .|.|.|.... .. ..  . | |.  . .  .. |   . .. ..|.|...| . |..||
GPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-HF-HWTF--HNWSEECKDFIKWCLCKDPKKRP

TPLETLLHPYF
|. . | ||.|
TAEQILQHPWF
Kinase 5825.AA S_TKc 49-335 28 1e-88 301.99 SMART 1-231 (231) Show / Hide 
Range on Protein: 49-335
Range on HMM: 1-231/231
Sequence Identity: 28% (85 aa)

ITLDKIIGNGTFGVVYLAKMNDTQEQVAIKKVFQDKRYKNREFEIIKSLNHQNLIKLKQAYYTTQNNNPDEVYLNIVMEYVPE---TLSKVIRTYRKSK-
 .. ..|| |.||.||... ..|...||||..    .   || .| |. .| |..||. ....         .| .||||..    .| ..|. ... . 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---EHIRREIQILKK-HHPNIVKLYDVFQD--------DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

-QPFPPLLLKVFSYQMFRALAYLKGIGICHRDIKPQNILCDQKTMQLKICDFGSAKKLIKGEPNVSYICSRYYRAPELIFGAEQYTT-AIDTWSIGTVIA
 .|||.   . . ||...||.|.   ||.|||.||.|||.|.   ..||||||.|..|       ... ...|.|||..    .|.. ..| ||.| ...
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILY

EMILGEPLFPGENAVEQLVEIIKILGTPTKEQVQKMNPQHNQFNFPSIKPTSWTKIFAKQKPDPMLIDLISRLLVFVPTDRPTPLETLL-------HPYF
||. |.|.||      |. ...|..|                                    .| ..|.|...|.. |..|||  | |        ||.|
EMLCGYPPFP------QMQMMFKKIG------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 5825.AA CDK 50-335 30 5e-71 226.45 In-house 2-284 (284) Show / Hide 
Range on Protein: 50-335
Range on HMM: 2-284/284
Sequence Identity: 30% (98 aa)

TLDKIIGNGTFGVVYLAKMNDTQ-----EQVAIKKVF--------QDKRYKN---REFEIIKSLNHQNLIKLKQAYYTT---QNNNPD--EVYLNIVMEY
   . || ||.|||| |.  .|.     . ||.||.          .        ||  . | | |.| .||.  ..|     ||  |  |  | .|.||
EKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNN-KDKHENKLYMVFEY

VPETLSKVIRTYRKSKQPFPPLLLKVFSYQMFRALAYLKGIGICHRDIKPQNILCDQKT----MQLKICDFGSAKKL-I------KGEPNVSYICSRYYR
..  |.|...              | . .|. |.|.|.   .| |||.|||||| . .     ..||| ||| |..  |      .  .  . .  . ||
MDHDLKKYMD-------------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYR

APELIFGAEQYT--TAIDTWSIGTVIAEMIL---GEPLFPGENAVEQLVEIIKILGTPTKEQ---VQKMNPQHNQFNFPSIKPTSWTKIFAKQKPDPMLI
|||| .|...|.  |.|| ||.| ..|||..   ..|||||..  .||  |..|.|||| ..   | |.                               
APELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY----------------------------

DLISRLLVFVPTDRPTPLETLLHPYF
||....|.. |. | .  . | ||||
DLLNKMLCYDPKKRISAEQALQHPYF
Kinase 5825.AA MAPK 49-335 31 1.2e-65 224.44 In-house 1-328 (328) Show / Hide 
Range on Protein: 49-335
Range on HMM: 1-328/328
Sequence Identity: 31% (104 aa)

ITLDKIIGNGTFGVVYLAKMND------TQEQVAIKKV---FQDKRYKN---REFEIIKSL-NHQNLIKLKQAYYTTQ---NNNP---DEVYLNIVMEYV
 ...| || | .|||  |. .       ....|||||.   ||.. .     ||  . . . .| | |||.  .. ..   .|..   ...|  ||||. 
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIY--IVMELM

PETLSKVIRTYRKSKQPFPPLLLKVFSYQMFRA--LAYLKGIGICHRDIKPQNILCDQKTMQLKICDFGSAKKLIKG--EPNV-------------SYIC
   | ..|.. .    |      . | ||. |.  | |.   .. |||.|| |||...    ||||||| | ..     ...               |. 
ETDLHQIIKSQQ----PLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCD-LKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVA

SRYYRAPELIFG--AEQYTTAIDTWSIGTVIAEMIL-GEPLFPGENAVEQLVEIIKILGTPTKEQVQKMN-PQHN-----QFN-FPSIKPTSWTKIFAKQ
 |.|||||....  .  ||.|.| ||.|   |||.  . |||||.. ..|.  |...||||..| .|..  ..|      ... .|  .. .|.|.| . 
TRWYRAPEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNA

K--PDPMLIDLISRLLVFVPTDRPTPLETLLHPYF
    .|. |||....||| | .| |  | | ||||
NFNANPQAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase 5825.AA CDC2 53-335 33 9.9e-64 194.54 In-house 5-301 (301) Show / Hide 
Range on Protein: 53-335
Range on HMM: 5-301/301
Sequence Identity: 33% (103 aa)

KIIGNGTFGVVYLAKMNDTQEQVAIKKVFQDKRYKN--------REFEIIKSLN-HQNLIKLKQAYYTTQNNNPDEVYLNIVMEYVPETLSKVIRTYRKS
. || ||.|||| .| ..|...||.||.  .             ||  ..| |. |.|..||.  ..           | .| ||.   | |  . . ..
EKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ--------NKLYMVFEYLDMDLKKYMDMSIPK

KQPFPPLLLKVFSYQMFRALAYLKGIGICHRDIKPQNILCDQKTMQLKICDFGSAKKLIKGEPNVSYICS-----RYYRAPELIFGAEQYTTAIDTWSIG
....|| |.| . ||. ......   .| |||.|||||| | |   .|| ||| |.    | |   |        . |||||. .|...|.|..| ||||
NKHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGN-IKIADFGLARAF--GIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIG

TVIAEM---ILGEPLFPGENAVEQLVEIIKILGTPTKEQVQKMNPQH-NQFNFPSIKPTSWTKIFAK-------QKPDPMLIDLISRLLVFVPTDRPTPL
 ..|||   .  .|||.|.   .||  | .|||||. .  . .      .  ||  ||.  .||. .          ||  |||....|.  | .| .  
CIFAEMFMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPDYKNTFPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRISAK

ETLLHPYF
| | ||||
EALQHPYF
Kinase 5825.AA CDK-Unclassified 51-274 32 7.3e-58 188.88 In-house 3-262 (324) Show / Hide 
Range on Protein: 51-274
Range on HMM: 3-262/324
Sequence Identity: 32% (88 aa)

LDKIIGNGTFGVVYLAKMNDTQEQVAIKKVFQDK-------------RYK---NREFEIIKSLNHQNLIKLKQAYYTTQNNN--PDEVYLN----IVMEY
 ....| |||| |..|   .|| .|||||..                . |   .||  . . .|| |.||. . .|        |    |.    .||||
MQCKYGEGTFGCVCKAIDFQTQKHVAIKKIMVNNKKGNKCKHILPLLNSKITDQREISCLQNCNHMNIIKFMDMHYDHDRCSKNPYYDNLHPSFYMVMEY

VPETLSKVIRTYRKSKQPFPPLL---LKVFSYQMFRALAYLKGIGICHRDIKPQNILCDQKT-----MQLKICDFGSAKKLI----------KGEPNVSY
.| |.. .    |       .|     . |  ||.  .|||   .| |||||||||. . ..     | ||| |||.| .              .|. .|
MPYTWYNQLHNNRY------NLSMCQIRNFMHQMLEGIAYLHCNKIMHRDIKPQNIMITNNNSTVSPM-LKIADFGQACFYMNCPPNLNYQTPADPMQQY

---ICSRYYRAPELIFGAEQYTTAIDTWSIGTVIAEMILGEPLFPGENAVEQLVEIIKILGTPTKEQ
   .  | |||||| ||  .|.|..| ||.| ..||.. | |.|.| . .||.  |.|.||||. ..
STQVSTRWYRAPELLFGSKCYDTGVDIWSFGCIYAEWFQGKPIFQGRTEIEQMHHIFKMLGTPCEDM
Kinase 5825.AA RCK 50-335 29 1.2e-57 181.39 In-house 2-298 (298) Show / Hide 
Range on Protein: 50-335
Range on HMM: 2-298/298
Sequence Identity: 29% (91 aa)

TLDKIIGNGTFGVVYLAKMNDTQEQVAIKKVFQDKRYKN-------REFEIIKSLN-HQNLIKLKQAYYTTQNNNPDEVYLNIVMEYVPETLSKVIRTYR
.. | .| ||.|.| .|.  .|.| |||||    .....       ||   .. || | |.||||   .   . .     | .|.||. . |.. .... 
QIIKQLGDGTYGCVMKAQNKETGEIVAIKKMK--QKFYSWEECMNLREIKSLRKLNPHPNIIKLKEVIRDNDTYQ-----LYFVFEYMDMNLYQMMKDFK

KSKQPFPPLL--LKVFSYQMFRALAYLKGIGICHRDIKPQNILCDQK--------TMQLKICDFGSAKKLIKGEPNVSYICSRYYRAPELIFGAEQYTTA
......|     .|   || . .||..   |. |||.|| ||.|  .        .  .||.|||...      |.  |. .|.|||||..  . .|.. 
ERRKYLPENQRSIKNIMYQILQGLAHMHKHGFFHRDLKPENIMCTGSQQYFEDQDQDHIKIADFGLCREIRSKPPYTDYVSTRWYRAPECLLRCTYYNSP

IDTWSIGTVIAEMILGEPLFPGENAVEQLVEIIKILGTPTKEQVQKMN--PQHNQFNFPSIKPTSWTKIFAKQKPDPMLIDLISRLLVFVPTDRPTPLET
.| |..| ...|     ||||| . . |. .|.|..|||.|.   .     .. .||||. |...  ...  . .|  .|.|.  .|   |  |.|. . 
MDIWAVGCIMYELYMLRPLFPGSSEIDQIFKICKVMGTPNKKDWPDGYKLASQMNFNFPQCKGMPLKQLIPNCSQD--CIELMEKMLQWDPQKRITAQQA

LLHPYF
| ||||
LQHPYF
Kinase 5825.AA ERK 50-335 32 1e-51 178.16 In-house 2-307 (307) Show / Hide 
Range on Protein: 50-335
Range on HMM: 2-307/307
Sequence Identity: 32% (103 aa)

TLDKIIGNGTFGVVYLAKMND-----TQEQVAIKKV---FQDKRYKN---REFEIIKSLN-HQNLIKLKQAYYTTQNNNPDEVYLNIVMEYVPETLSKVI
 . | || |..|||  |. .      |.. |||||.   | ...| .   ||  . . .. | |.|.|.     .. .. ...|  .| |.    | ..|
QIIKQIGHGAYGVVCSAIDKEYCFDETGQKVAIKKIENAFDHPIYCKRTLREIKLLRHFKGHENIICLFDIMMPNSPEQYNDIY--CVEELMETDLHQII

RTYRKSKQPFPPLLLKVFSYQMFRALAYLKGIGICHRDIKPQNILCDQKTMQLKICDFGSAK----KLIKGEPNV------SYICSRYYRAPELIFGAEQ
    .|.|.  .   . | ||. ..| |.   .. |||.|| |||.  .  .||||||| |     .  ...  .       |. .|.|||||..  .. 
----NSQQELSDDHCQYFMYQILCGLKYIHSANVIHRDLKPSNILVN-SNCDLKICDFGLARCFDASYQENHE-CNQNFMTEYVATRWYRAPEIMLSWQK

YTTAIDTWSIGTVIAEMILGEPLFPGENAVEQLVEIIKILGTP-TKEQVQKM-NPQHNQF--NFPS--IKPTSWTKIFAKQKPDPMLIDLISRLLVFVPT
||.|.| ||.|  .|||. . |||||.. |.|. .|..|.||| ..|..|.  ...  ..  |.|   ..| .| .|| .    |  |||....||| |.
YTKAMDIWSCGCIFAEMLGRKPLFPGKDYVHQINRIFQIIGTPHSEEDLQYICSENAWKYIKNLPNPVRPPKPWENIFPNANCNPQAIDLLEKMLVFDPD

DRPTPLETLLHPYF
.| |  | | ||||
KRITVEECLEHPYF
Kinase 5825.AA CAMK 54-238 19 5e-49 155.72 In-house 1-321 (425) Show / Hide 
Range on Protein: 54-238
Range on HMM: 1-321/425
Sequence Identity: 19% (62 aa)

IIGNGTFGVVYLAKMNDTQ------------EQVAIKKVF--------------------------------QDKRYKNREFEIIKS-------LNHQNL
..| |.||.|.|..   |.            ..|||| .                                 .|..   || || |.       |.| |.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IKLKQAYYTTQN--------NNPD-----EVYLNIVM---EYVPET------LSKVI-RTYRKSK---------QPFPPLLLKVFSYQMFRALAYLKGIG
||| ..| ....        .  .     . .. .||   ||..        ..... ....  .           |.    . .  |.  |..|.   .
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

ICHRDIKPQNILCDQKT----------------MQLKICDFGSAKKLIKGEPNV------------------------SYICSRYYRA-PELIFG-----
|.|||.|| |||.|..                  ..||.||| |.|...|| |                          .  . .| | ||.. |     
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

--------AEQYTTAIDTWSIG
         . |. ..| ||.|
MQNATDEEKPYYGPKCDMWSCG
Kinase 5825.AA DYRK 143-335 30 4.1e-45 156.2 In-house 95-320 (320) Show / Hide 
Range on Protein: 143-335
Range on HMM: 95-320/320
Sequence Identity: 30% (70 aa)

SKQPF-PPLLLKVFSYQMFRALAYLKGI-GICHRDIKPQNILCDQ--KTMQLKICDFGSAKKLIKGEPNVSYICSRYYRAPELIFGAEQYTTAIDTWSIG
..|.| .  | ..| .|.. .| .|.    | | |.|| ||.  |  .  ..|..||||.    .     .|| ||.||||| | |  .| .||| || |
HFQGFFSLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENIMLKQPRNKSTIKVIDFGSSCFEHQ--RIYTYIQSRFYRAPEVILGC-PYCYAIDMWSLG

TVIAEMILGEPLFPGENAVEQLVEIIKILGTPTKEQVQK--------------------------------MNPQHNQFNFPSIKPTSWT--KIFAKQKP
 ..||. .|.||||||| ..||  |. .|| |.|. ..|                                . ..|.  .  ...| . .  . . . . 
CILAELFTGWPLFPGENEYDQLACIMEVLGMPPKWMIDKGRCRRKHKFFDCFMYCECDEWTKQNKITDHYMTPKCHPTKR-GQRRPPGRRNWDPRHQ-CD

DPMLIDLISRLLVFVPTDRPTPLETLLHPYF
| ...|.| ..|.. |. |.|| . | || |
DHQFKDFIKKCLQWDPHKRITPSQALQHPWF
Kinase 5825.AA Pkinase_Tyr 49-196 30 7.3e-16 54.35 Pfam 1-156 (270) Show / Hide 
Range on Protein: 49-196
Range on HMM: 1-156/270
Sequence Identity: 30% (49 aa)

ITLDKIIGNGTFGVVYLAKMN----DTQEQVAIKKVFQDKRYKN-------REFEIIKSL-NHQNLIKLKQAYY-TTQNNNPDEVYLNIVMEYVPE-TLS
||..| .| | ||.||.....    .|. .||.|.. ..   ..       || .| |.| .|.|...|  . .   . |     .. |||||.|   | 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN-----QIYIVMEYMPHGDLL

KVIRTYRKSKQPFPPLLLKVFSYQMFRALAYLKGIGICHRDIKPQNILCDQKTMQLKICDFG
.  |. | .|||...  |  ...|  ....||  ... |||.   |.| .  ... ||||||
DYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE-NNVVKICDFG
Kinase 5825.AA TyrKc 49-335 24 9.3e-14 -0.27 SMART 1-280 (280) Show / Hide 
Range on Protein: 49-335
Range on HMM: 1-280/280
Sequence Identity: 24% (78 aa)

ITLDKIIGNGTFGVVYLAKMNDTQEQVAIKKVFQDKRYKN--REFEIIKSL--NHQNLIKLKQAYYTTQNNNPDEV----YLNIVMEYVPE-TLSKVIRT
|||.|..|.| ||.||.....   .|||.|..  |.  .   || .| ..|  .|.|...|  .  . . |          | |||||.|   | . .| 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN----FMYIEPLMIVMEYMPHGDLKDYLRK

YRKSKQPFPPLLLKVFSYQMFRALAYLKGIGICHRDIKPQNILCDQKTMQLKICDFGSAKKLIKG----EPNVSYI-----CSR-----YYRAPELIFGA
.|.    ...  |  |..|  .  .||   .. |||.   |.| . .  . ||.||| ....  .    |    |      ...        ||| |   
HRPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI--N

EQ-YTTAIDTWSIGTVIAEMI-LGEPLFPGE----NAVEQLVEIIKILGTPTKEQV----QKMNPQHNQFNFPSIKPTSWTKIFAKQKPDPMLIDLISRL
.  .||. | || | .. |.  .|..  ||.       ....| .|  . . . .                            |    || |   .... 
YGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS----------------------F-VCCPDEMYQ-IMKQC

LVFVPTDRPTPLETLLHPYF
  . | ||||  |   | .|
WHEDPEDRPTFSEI--HECF
Kinase 5825.AA CAMK 304-335 20 3e-07 18.65 In-house 367-425 (425) Show / Hide 
Range on Protein: 304-335
Range on HMM: 367-425/425
Sequence Identity: 20% (12 aa)

PDPM---------------------------LIDLISRLLVFVPTDRPTPLETLLHPYF
|.|.                            .|||...|.  |..|.|  . | || .
PPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 5825.AA DYRK 49-78 40 4.5e-05 15.2 In-house 1-30 (320) Show / Hide 
Range on Protein: 49-78
Range on HMM: 1-30/320
Sequence Identity: 40% (12 aa)

ITLDKIIGNGTFGVVYLAKMNDTQEQVAIK
 . ...|| |.|| |  .. . |.| ||||
YEILEYIGKGSFGQVVKCWDHKTNEMVAIK
Kinase 5825.AA CDK-Unclassified 309-335 25 0.004403 5.83 In-house 298-324 (324) Show / Hide 
Range on Protein: 309-335
Range on HMM: 298-324/324
Sequence Identity: 25% (7 aa)

IDLISRLLVFVPTDRPTPLETLLHPYF
..... .... |  |..  | | ||.|
NNCEFQMVMYQPYNRWKCMEILQHPWF