Gene 19923 (Tetrahymena)

19923

Species: Tetrahymena
Alias: 19923, 3830.m00576, 117, 68.m00212, PreTt19923, TTHERM_00532670
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: CMGC
Family: GSK

Sequence

Name Sequence Type Origin Length Description Download
19923.AA Protein None 399 None Fasta, JSON
19923.kin_dom Protein Kinase Domain None 266 None Fasta, JSON
19923.NA RNA None 1200 None Fasta, JSON

Protein domain

Protein domains of 19923.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 19923.AA GSK 50-332 51 1e-204 631.92 In-house 1-328 (328) Show / Hide 
Range on Protein: 50-332
Range on HMM: 1-328/328
Sequence Identity: 51% (171 aa)

IQGDNIVGNGTFG----ATIN----ETGET----VAIKKVFQDRRYK-NRELQIMKEIG--NHPNVISLRNYFYIYADDKQE-DVYLN-IIMDYIPETLY
.. .. .|.|.||    |..|    ||.|.    ||||||.||.||| ||||||||..|  .|||...|...|| ....|.| .||.| ..|.|.|.|||
YEEMKVIGHGSFGVVYQAYMNSPSNETKEIWLGPVAIKKVWQDKRYKCNRELQIMKMLGKLDHPNIVRLKYFFYMHYEKKDENHVYCNCLVMEYMPQTLY

RMIKYFAKKSKGNFPNILLKLYSYQLMRSLAYIQGLGICHRDIKPTNVLVDPRNHALKMCDFGSAKKLNP--SETNISYICSRYYRAPELMFMATQYTNS
..|....| .| ..|.|..|||.||..|.|||....||||||||| |.||||... ||.|||||||.| |  .|.|||||||||||||||.|..|.||..
QVIRHYVK-NKQQMPIIHIKLYMYQMFRGLAYLHSHGICHRDIKPQNILVDPDTGVLKICDFGSAKQLEPNKNEPNISYICSRYYRAPELIFGCTNYTCQ

IDVWSVGCVIAEMVLGDPIFAGESSVDQLIEIIKILGTPTLQQH--MNPDHQPTQMP-----KIKPTPWSK-------------------VFKNCKVDP-
|||||.|||.|||..| |.|.|.||||||.||||.||||| .|.  |||... ...|     .|||.||.|                   .||.|. |. 
IDVWSCGCVMAEMLKGQPLFPGDSSVDQLVEIIKMLGTPTKEQIQSMNPSYPEFKFPYWSFQQIKPHPWQKNDTKYEYQTYYHKKYRTVYMFKWCHTDMQ

LAIDLISKVLVYSPQLRLKPLEALAHPFF
 .||||||.||| |. ||.||||.|||||
DWIDLISKCLVYDPKKRLSPLEACAHPFF
Kinase 19923.AA CMGC 50-332 21 4.3e-110 363.12 In-house 1-513 (513) Show / Hide 
Range on Protein: 50-332
Range on HMM: 1-513/513
Sequence Identity: 21% (110 aa)

IQGDNIVGNGTFGATIN------------------ETGETVAIKKVFQDRRYKN----------------RELQIMKEIG----------------NHPN
 . .. .| ||.|                      ||.| |||||....  |..                ||..|.|..                 .|.|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

VISLRNYFYIYADDKQEDV----------YLNIIMDYIPETLYRMIKYFAKK-----------------------SKGNFPNILLKLYSYQLMRSLA--Y
...|...||   .|..|.           .|.....|.. .||..||   ..                       .. .|.. . . |.||. |.|.  |
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKY

IQGLG--ICHRDIKPTNVLVDPRN-------------------HALKMCDFGSAKKLNP----------------------SETNISYICSRYYRAPELM
.   .  |.|||.|| |.|.....                     || ||||.|....|                      .... .|...|.|||||..
CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEIL

FMATQYT---------NSIDVWSVGCVIAEMVLG--------DPIFAGESS-----------VDQLIEIIKILGTPT---------------LQQHMN--
. ...||          .||.|||||..|||..|        .|.| |.|.           .||| .|.|.|||||                .. .|  
LGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMI

--PDHQP--------------TQ-----------MPKIKPTPWSKVFKNCK---------------------------------VDPLAIDLISKVLVYS
  |....              .             |...| ||...|.. .                                  ||.||||..| |.| 
KLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYD

PQLRLKPLEALAHPFF
|. |... .||.||.|
PDKRITAEQALQHPYF
Kinase 19923.AA S_TKc 50-332 27 5e-67 229.9 SMART 1-231 (231) Show / Hide 
Range on Protein: 50-332
Range on HMM: 1-231/231
Sequence Identity: 27% (82 aa)

IQGDNIVGNGTFG----ATINETGETVAIKKVFQDRRYKNRELQIMKEIGNHPNVISLRNYFYIYADDKQEDVYLNIIMDYIPE---TLYRMIKYFAK-K
 .  ...| |.||    .. ..||. ||||..    .   ||.||.|.  .|||.. |  .|.          .| ..|.|..    .|...||   . .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---EHIRREIQILKK--HHPNIVKLYDVFQD--------DHLYMVMEYCDGDLGDLFDYIKKRGRHG

SKGNFPNILLKLYSYQLMRSLAYIQGLGICHRDIKPTNVLVDPRNHALKMCDFGSAKKLNPSETNISYICSRYYRAPELMFMATQYTN-SIDVWSVGCVI
 .  ||    . | ||. . |.|.  .||.|||.|| |.|.|     .| ||||.|..|       ... ...|.|||..    .|.  ..|.||.||..
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCIL

AEMVLGDPIFAGESSVDQLIEIIKILGTPTLQQHMNPDHQPTQMPKIKPTPWSKVFKNCKVDPLAIDLISKVLVYSPQLRLKPLEALA-------HPFF
.||. | | |       |. ...|..|                                  .| |.|.|.| |.. |. |.   |||.       ||.|
YEMLCGYPPFP------QMQMMFKKIG----------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 19923.AA CDK 51-332 27 9e-63 199.59 In-house 2-284 (284) Show / Hide 
Range on Protein: 51-332
Range on HMM: 2-284/284
Sequence Identity: 27% (90 aa)

QGDNIVGNGTFG----ATINETG-----ETVAIKKVFQDR--------RYKN---RELQIMKEIGNHPNVISLRNYFYIYADDKQE----DVYLNIIMDY
.  . .| ||.|    |   .||     . ||.||.  .                ||  ..||.  |||...|.  ..  ..|..     .  | ....|
EKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL--HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

IPETLYRMIKYFAKKSKGNFPNILLKLYSYQLMRSLAYIQGLGICHRDIKPTNVLVDPRNH----ALKMCDFGSAKKLN-------PSETNISYICSRYY
..  |.  ..               | | .||.| |.|.   .| |||.|| | |.. . .     ||  ||| |.. .       |. |  . .  . |
MDHDLKKYMD--------------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWY

RAPELMFMATQYT--NSIDVWSVGCVIAEMVL---GDPIFAGESSVDQLIEIIKILGTPTLQQHM----NPDHQPTQMPKIKPTPWSKVFKNCKVDPLAI
||||| . ...|.   .||.|||||..|||..   . |.| |.|  |||  |..|.|||| ..       ||.                           
RAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY---------------------------

DLISKVLVYSPQLRLKPLEALAHPFF
||..| |.| |. |..  .|| ||.|
DLLNKMLCYDPKKRISAEQALQHPYF
Kinase 19923.AA Pkinase 50-332 26 1.8e-60 211.97 Pfam 1-293 (293) Show / Hide 
Range on Protein: 50-332
Range on HMM: 1-293/293
Sequence Identity: 26% (83 aa)

IQGDNIVGNGTFG----ATINETGETVAIKKVFQDRRYKNR--------ELQIMKEIGNHPNVISLRNYFYIYADDKQEDVYLNIIMDYIPETLYRMIKY
..   ..| |.||    ..   ||..||.|..  ... ..         |.||||.. ||||.. |. .|.        . .. ..|.| . .||  .  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED-------KDHIYMVMEYCEGGLY-VMDL

F----AKKSKGNF--PNILLKLYSYQLMRSLAYIQGLGICHRDIKPTNVLVDPRNHA---LKMCDFGSAKK--LNPSETNISYICSRYYRAPELMFMATQ
|    . ...|.|  .   .| | ||. | |.|.   ||.|||.|| |.|.| ..|    .| ||||.||.  . ... . .. ....|.|||.   .. 
FDYIST-WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQY

YTNSIDVWSVGCVIAEMVLGDPIFAGE----SSVDQLIEIIKILGTPTLQQHMNPDHQPTQMPKIKPTPWSKVFKNCKVDPLAIDLISKVLVYSPQLRLK
|. ..|.||.||...||..| |.| |.    . .||.  | .|.|.|.  .  ...  .. . .. . .    ..  .... ..|.|.. | . |. |. 
YGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRH-W-HF-HWTF-HNWSEECKDFIKWCLCKDPKKRPT

PLEALAHPFF
. ..| ||.|
AEQILQHPWF
Kinase 19923.AA CDC2 56-332 31 5.5e-59 179.68 In-house 7-301 (301) Show / Hide 
Range on Protein: 56-332
Range on HMM: 7-301/301
Sequence Identity: 31% (95 aa)

VGNGTFG----ATINETGETVAIKKVFQDRRYKN--------RELQIMKEIGNHPNVISLRNYFYIYADDKQEDVYLNIIMDYIPETLYRMIK-YFAKKS
.| ||.|    .  ..|.. ||.||.  ..            ||. ..||. .|||...|.  ...          | .. .|.   | .  . .. |. 
IGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ--------NKLYMVFEYLDMDLKKYMDMSIPKN-

KGNFPNILLKLYSYQLMRSLAYIQGLGICHRDIKPTNVLVDPRNHALKMCDFGSAKKLN-PSETNI--SYICSRYYRAPELMFMATQYTNSIDVWSVGCV
  ..| .|.| | ||. . ...    .| |||.|| | |.| .. ..|  ||| |.  . |. |      .  . |||||... . .|. ..|.||.||.
-KHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILID-KKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCI

IAEM---VLGDPIFAGESSVDQLIEIIKILGTPTLQQHMNPDHQP---TQMPKIKPTPWSKVFKN-------CKVDPLAIDLISKVLVYSPQLRLKPLEA
.|||   |   |.|.|.|  |||  | .|||||. |  .. .  |   .  |. ||.  ||...|         .|| .|||... |.| || |..  ||
FAEMFMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPDYKNTFPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRISAKEA

LAHPFF
|.||.|
LQHPYF
Kinase 19923.AA MAPK 67-332 31 3.8e-56 192.61 In-house 28-328 (328) Show / Hide 
Range on Protein: 67-332
Range on HMM: 28-328/328
Sequence Identity: 31% (97 aa)

ETGETVAIKKV---FQDRRYKN---RELQIMKEIGNHPNVISLRNYFYI------YADDKQEDVYLNIIMDYIPETLYRMIK-YFAKKSKGNFPNILLKL
..|..|||||.   ||.  .     ||. .......|.|.|.|.. |.       .  .. .|.|  |.|..    |.. ||            ..  . 
KCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIY--IVMELMETDLHQIIKSQQ------PLSDDHIQY

YSYQLMRS--LAYIQGLGICHRDIKPTNVLVDPRNHALKMCDFGSAKKLNPSETNI---------------SYICSRYYRAPELMFM--ATQYTNSIDVW
  ||. |   | ||   .. |||.|| |.||.  |  ||.|||| | .. |... .                |.  |.|||||.|.   .. || ..|.|
FMYQILRGLKLKYIHSANVIHRDLKPSNILVN-ENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAPEIMLNWIWMHYTKAVDMW

SVGCVIAEMVL-GDPIFAGESSVDQLIEIIKILGTPTLQQHMNPD--HQP----TQM---PKIKPTPWSKVFKNCK--VDPLAIDLISKVLVYSPQLRLK
||||  |||.  . |.| |....||.  |...||||. .   .    . .     ..   || .. ||.|.|.|    ..|.||||..| || .|. |. 
SVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANPQAIDLLEKMLVFDPDKRIT

PLEALAHPFF
  |||.||.|
VEEALQHPYF
Kinase 19923.AA CK2 86-332 29 1.6e-54 160.84 In-house 44-288 (288) Show / Hide 
Range on Protein: 86-332
Range on HMM: 44-288/288
Sequence Identity: 29% (77 aa)

RELQIMKEIGNHPNVISLRNYFYIYADDKQEDVYLNIIMDYIPETLYRMIKYFAKKSKGNFPNILLKLYSYQLMRSLAYIQGLGICHRDIKPTNVLVDPR
||..|....  .||.| |    |    |..  |   .. .|. .| .| . .        .    .. | ..|.. | |    || |||.|| |...|..
REIKILENLNGGPNIIKL----YDIVKDPYSKVP-ALVFEYVNNTDFRQLYQ-------TLTDYDIRYYMFELLKALDYCHSMGIMHRDVKPHNIMIDHE

NHALKMCDFGSAKKLNPSETNISYICSRYYRAPELMFMATQYTNSIDVWSVGCVIAEMVLG-DPIFAGESSVDQLIEIIKILGTPTLQQHMN------PD
.  |.. | | |    | . .   . ||||..|||.    .|  |.|.||.||..| |..  .| | |... |||..|.|.|||  | . ..      ..
KRKLRLIDWGLAEFYHPGQDYNVRVASRYYKGPELLVDYQYYDYSLDMWSLGCMFASMIFKKEPFFHGHDNYDQLVKIVKVLGTEDLYKYLDKYGIHLDP

HQPTQMPKIKPTPWSKVFKN---CKVDPLAIDLISKVLVYSPQLRLKPLEALAHPFF
..   | . |  ||..  ..     ..| |||...| |.| .| |. . ||. ||.|
QFHDIMQQHKKKPWERFIHQENKHLAHPEAIDFLDKMLRYDHQERITAKEAMEHPYF
Kinase 19923.AA ERK 156-332 37 2.5e-53 183.49 In-house 115-307 (307) Show / Hide 
Range on Protein: 156-332
Range on HMM: 115-307/307
Sequence Identity: 37% (73 aa)

YQLMRSLAYIQGLGICHRDIKPTNVLVDPRNHALKMCDFGSAKKLNPSETNI---------SYICSRYYRAPELMFMATQYTNSIDVWSVGCVIAEMVLG
||. . | ||   .. |||.|| |.||   |  || |||| | ....|  ..          |. .|.|||||.|  .. || ..|.||.|| .|||. .
YQILCGLKYIHSANVIHRDLKPSNILVN-SNCDLKICDFGLARCFDASYQENHECNQNFMTEYVATRWYRAPEIMLSWQKYTKAMDIWSCGCIFAEMLGR

DPIFAGESSVDQLIEIIKILGTP----TLQQHMNPDHQP--TQMPK--IKPTPWSKVFKNCKVDPLAIDLISKVLVYSPQLRLKPLEALAHPFF
.|.| |...|.|. .|..|.|||    .||.  ... .   ...|.  ..| ||...|.|  . |.||||..| ||  |. |.   |.|.||.|
KPLFPGKDYVHQINRIFQIIGTPHSEEDLQYICSENAWKYIKNLPNPVRPPKPWENIFPNANCNPQAIDLLEKMLVFDPDKRITVEECLEHPYF
Kinase 19923.AA RCK 56-332 30 1.9e-49 154.89 In-house 7-298 (298) Show / Hide 
Range on Protein: 56-332
Range on HMM: 7-298/298
Sequence Identity: 30% (91 aa)

VGNGTFG----ATINETGETVAIKKVFQDRRYKN-------RELQIMKEIGNHPNVISLRNYFYIYADDKQEDVYLNIIMDYIPETLYRMIKYFAKKSKG
.| ||.|    |   |||| |||||    .....       ||.. .. .  |||.| |.  ...     ...  | ... |  . || |.| |.. .. 
LGDGTYGCVMKAQNKETGEIVAIKKMK--QKFYSWEECMNLREIKSLRKLNPHPNIIKLKEVIRD-----NDTYQLYFVFEYMDMNLYQMMKDFKE-RRK

NFPNIL--LKLYSYQLMRSLAYIQGLGICHRDIKPTNVLVDPR--------NHALKMCDFGSAKKLNPSETNISYICSRYYRAPELMFMATQYTNSIDVW
 .| .   .| . ||.  .||..   |. |||.|| | .. .         .  .| .|||...       .  |. .|.|||||.   .|.|.  .|.|
YLPENQRSIKNIMYQILQGLAHMHKHGFFHRDLKPENIMCTGSQQYFEDQDQDHIKIADFGLCREIRSKPPYTDYVSTRWYRAPECLLRCTYYNSPMDIW

SVGCVIAEMVLGDPIFAGESSVDQLIEIIKILGTPTLQQHMNPDHQPTQM----PKIKPTPWSKVFKNCKVDPLAIDLISKVLVYSPQLRLKPLEALAHP
.|||...|     | |.| | .||. .|.|..|||. .       . .||    |. |..| .... ||  |  .|.|. | | . || |  . .|| ||
AVGCIMYELYMLRPLFPGSSEIDQIFKICKVMGTPNKKDWPDGYKLASQMNFNFPQCKGMPLKQLIPNCSQD--CIELMEKMLQWDPQKRITAQQALQHP

FF
.|
YF
Kinase 19923.AA ERK7 48-332 30 1.4e-46 157.17 In-house 1-292 (292) Show / Hide 
Range on Protein: 48-332
Range on HMM: 1-292/292
Sequence Identity: 30% (95 aa)

YSIQGDNIVGNGTFG----ATINETGETVAIKKVFQDRRYKN------RELQIMKEIGNHPNVISLRNYFYIYADDKQEDVYLNIIMDYIPETLYRMIKY
| |.    .| | .|    |.   |...||.||.|   | .       ||  ...|...|||.|.| |   .   |   |.||  . ..    |   |. 
YEIR--KRLGKGAYGIVWKAYDKRTKQVVALKKIFDAFRNQTDAQRTFREIMFLQEFHCHPNIIRLIN---VIRADNDRDIYL--VFEFMETDLHAVIR-

FAKKSKGN-FPNILLKLYSYQLMRSLAYIQGLGICHRDIKPTNVLVDPRNHALKMCDFGSAKKLNPSE-------TNISYICSRYYRAPELMFMATQYTN
     |||   .|  .   |||.| . |.    . |||.|| |.|.|  .  .|.|||| |  .   |           |.  | ||||| .  ...|| 
-----KGNILKDIHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLD-SECMVKVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTK

SIDVWSVGCVIAEMVLGDPIFAGESSVDQLIEIIKILGTPTLQ--QHMNPDHQPT---QMPKIKPTPWSKVFKNCKVDPLAIDLISKVLVYSPQLRLKPL
 .| ||.||...||. | |.|.| | ..|.  |..... || .  . ....   .   ||.. |. . ......|  |  ||||. . ||. |. ||   
GVDMWSIGCILGEMLRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMPQCCDD--AIDLLKRLLVFNPKKRLTAE

EALAHPFF
.||.||. 
QALQHPYV
Kinase 19923.AA CDKL 150-332 33 2.8e-44 149.28 In-house 99-286 (286) Show / Hide 
Range on Protein: 150-332
Range on HMM: 99-286/286
Sequence Identity: 33% (64 aa)

LLKLYSYQLMRSLAYIQGLGICHRDIKPTNVLVDPRNHALKMCDFGSAKKLN-PSETNISYICSRYYRAPELMFMATQYTNSIDVWSVGCVIAEMVLGDP
... | .|.......     . |||||| | |. |.|  .|.|||| |. |. |.|    |   | ||||||.   |||  ..|.|..|||.|||. | |
VVRKYMWQILKAINFCHKHNCIHRDIKPENILITPKNGQVKLCDFGFARMLAKPGEIYTDYVATRWYRAPELLVGDTQYGKPVDIWAIGCVMAEMIDGQP

IFAGESSVDQLIEIIKILGTPTLQQH----MNPDHQPTQMPKIKPTPWSKVFKNCKVD-PLAIDLISKVLVYSPQLRLKPLEALAHPFF
.. |.| .|||  |.| ||. . ...    .||     ..|.|. .. .   .  ..  ..|.|.. | |  .|  |.   ... ||.|
LWPGQSDIDQLYHIQKCLGPLIPRHQEIFSKNPFFHGMKFPEIE-HMEPLEKRYPNKSNKKALDFMKKCLHMDPDERMTCEQLMHHPYF
Kinase 19923.AA TyrKc 50-332 20 2.5e-10 -55.53 SMART 1-280 (280) Show / Hide 
Range on Protein: 50-332
Range on HMM: 1-280/280
Sequence Identity: 20% (64 aa)

IQGDNIVGNGTFG----ATINETGETVAIKKVFQDRRYKN--RELQIMKEIG-NHPNVISLRNYFYIYADDKQ-----EDVYLNIIMDYIPETLYRMIKY
|. . . |.| ||    .| .   ..||.|..  |   .   ||..||...| .|||.. |   . .  ...      | ..  |.| | |   .   | 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRL---YGVCTQQGRNFMYIEPLM--IVMEYMP---HGDLKD

FAKKSKGNFPNILLKLYSYQLMRSLAYIQGLGICHRDIKPTNVLVDPRNHALKMCDFGSAKKLNPS--------ETNISY-ICSR-----YYRAPELMFM
. .|.......  |  ...|  .  .|.   .. |||.   |.||. ..   | .||| ....               .   ...        ||| . .
YLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-N

ATQYTNSIDVWSVGCVIAEMV-LGDPIFAGE----SSVDQLIEIIKILGTPTLQQH---MNPDHQPTQMPKIKPTPWSKVFKNCKVDPLAIDLISKVLVY
   .|   |||| | .. |.  .|..   |.     | ...|| .|  . .   ..   |                    |  |  | .   ....   .
YGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS-------------------F-VCCPDEMYQ-IMKQCWHE

SPQLRLKPLEALAHPFF
 |  |    |   | .|
DPEDRPTFSEI--HECF
Kinase 19923.AA ERK 48-120 27 0.000238 12.33 In-house 1-86 (307) Show / Hide 
Range on Protein: 48-120
Range on HMM: 1-86/307
Sequence Identity: 27% (24 aa)

YSIQGDNIVGNGTFG----ATINE-----TGETVAIKKV---FQDRRYKN---RELQIMKEIGNHPNVISLRNYFYIYADDKQEDVYL
|.|   . .| |..|    |. .|     ||..|||||.   | ...| .   ||. ...    |.|.|.|.. .     .. .|.|.
YQII--KQIGHGAYGVVCSAIDKEYCFDETGQKVAIKKIENAFDHPIYCKRTLREIKLLRHFKGHENIICLFDIMMPNSPEQYNDIYC