Gene 10580 (Tetrahymena)

10580

Species: Tetrahymena
Alias: 10580, 12, PreTt10580, 92.m00122, TTHERM_00641110
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: CMGC
Family: DYRK
Subfamily: DyrkP

Sequence

Name Sequence Type Origin Length Description Download
10580.AA Protein None 536 None Fasta, JSON
10580.NA RNA None 1611 None Fasta, JSON
10580.kin_dom Protein Kinase Domain None 323 None Fasta, JSON

Protein domain

Protein domains of 10580.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 10580.AA DyrkP 205-527 87 4.5e-289 963.88 In-house 1-323 (323) Show / Hide 
Range on Protein: 205-527
Range on HMM: 1-323/323
Sequence Identity: 87% (284 aa)

YQIMEYLGSAAFSKAIQCQDKQTGQMLCMKIIENNKDYFDQSIDEIKLLKYINYNGDVDEKNVLKVYDYFYHKEHLFIVTELLKDNLYEFYKFNRENETQ
|||||||||||||||||||||||.||.||||||||||||||||||||||.||||||||||||||..||||||||||||.|||||||||||||||||||.|
YQIMEYLGSAAFSKAIQCQDKQTNQMMCMKIIENNKDYFDQSIDEIKLLRYINYNGDVDEKNVLRYYDYFYHKEHLFIITELLKDNLYEFYKFNRENEQQ

PYFTLGRLQKITQQILIGLDYIHSLRLIHCDLKPENILMKSYSKCQVKIIDFGSSCFIHDHLSSYVQSRSYRAPEVILGCKYDYKIDMWSLGCILAELWT
.|||.||||||||||||.||||||||||||||||||||||||.||||||||||||||||||||||||||||||||||.||||||.|||||||||||||||
RYFTVGRLQKITQQILIALDYIHSLRLIHCDLKPENILMKSYPKCQVKIIDFGSSCFIHDHLSSYVQSRSYRAPEVIIGCKYDYRIDMWSLGCILAELWT

GNVLFQNDTVQGLLARVIGIIGPIPEWMFQEGRLVNNFFTNKRLLYQDVFEEGEPSQNINDTSDMPGRRQKSGKIQILVPKKSNLRARLKTDDLMFLDFV
||||||||..|||||||||||||.||||.||||||.||||.|||||.|||||...||||||..||...|||.|||||||||.|||||||.|||.||.|||
GNVLFQNDNIQGLLARVIGIIGPFPEWMMQEGRLVQNFFTRKRLLYMDVFEEADQSQNINDQQDMQRQRQKTGKIQILVPKHSNLRARLRTDDHMFIDFV

KSLLQIDRTRRPSAKEALQHPWL
...||||.||||.|||||||||.
RQCLQIDFTRRPTAKEALQHPWF
Kinase 10580.AA DYRK 205-527 43 1.6e-169 569.47 In-house 1-320 (320) Show / Hide 
Range on Protein: 205-527
Range on HMM: 1-320/320
Sequence Identity: 43% (142 aa)

YQIMEYLGSAAFSKAIQCQDKQTGQMLCMKIIENNKDYFDQSIDEIKLLKYINYNGDVDEKNVLKVYDYFYHKEHLFIVTELLKDNLYEFYKFNRENETQ
|.|.||.|.  |.. ..|.|..|..|...|||.|||....|...|||.|.|.|.... |...... ||||||..||.||.|||  |||||.|.|....  
YEILEYIGKGSFGQVVKCWDHKTNEMVAIKIIRNNKRFHRQAQIEIKILEYLNQQDPDDKYHCVHMYDYFYHRNHLCIVFELLSMNLYEFLKNNHFQGF-

PYFTLGRLQKITQQILIGLDYIHSL-RLIHCDLKPENILMKSY-SKCQVKIIDFGSSCFIHDHLSSYVQSRSYRAPEVILGCKYDYKIDMWSLGCILAEL
  |.| . .|..|||| .|...|.. ..||||||||||..|.  .|...|.||||||||.|.....|.||| ||||||||||.|.|.|||||||||||||
--FSLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENIMLKQPRNKSTIKVIDFGSSCFEHQRIYTYIQSRFYRAPEVILGCPYCYAIDMWSLGCILAEL

WTGNVLFQNDTVQGLLARVIGIIGPIPEWMFQEG--RLVNNFFTNKRLLYQDVFEEGEPSQNINDTSDMPGRRQKSGKIQILVPKKSNLRARLKTDDLMF
.||..||.... . .||... ..|..|.||...|  | ...||..   .......| . ...|.|....| . .... .|...|...|. .|...||..|
FTGWPLFPGENEYDQLACIMEVLGMPPKWMIDKGRCRRKHKFFDC---FMYCECDEWTKQNKITDHYMTPKCHPTKR-GQRRPPGRRNWDPRHQCDDHQF

LDFVKSLLQIDRTRRPSAKEALQHPWL
.||.| .||.| ..|.....||||||.
KDFIKKCLQWDPHKRITPSQALQHPWF
Kinase 10580.AA CMGC 205-527 21 4.7e-108 356.3 In-house 1-513 (513) Show / Hide 
Range on Protein: 205-527
Range on HMM: 1-513/513
Sequence Identity: 21% (114 aa)

YQIMEYLGSAAFSKAIQCQDKQTG--------------QMLCMKIIENNKDYFDQSI-------------DEIKLLKYINYNGDVDE-----------KN
|.|....|. ....  .|.||.|.              ..  .|.| |.. | .|               .|||.||..|.|.|  .           .|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDP-NWQRRDDPDNKHHN

-VLKVYDYFYHKE-----------------HLFIVTELLKDNLYEFYKFNREN----------------------ETQPYFTLGRLQKITQQILIGLD--
 ..| ||.||||.                 ||..|.|..  .||.. | |. .                      ..  ||..   . ...||| ||.  
NIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLK

YIHSLR--LIHCDLKPENILMKS------------------YSKCQVKIIDFGSSCFIHDH------------------------LSSYVQSRSYRAPEV
|.|| .   ||.||||||||. .                  ... ..||.|||.....|.|                        ...||..| |||||.
YCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEI

ILGCK----------YDYKIDMWSLGCILAELWTG--------NVLFQNDTV-----------QGLLARVIGIIGPIPEWMFQEGRLVN--------NFF
.||.|          |...|||||.|||.||..||          ||. ..            .  |.. . ..|... ||.| |. ..        ...
LLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPT-WMIQKGK-RHFNFCKHEEEWP

TNKRLLYQDVFEEGEPSQNINDTSDMPGRRQKSGKI-----QILVPKKSNLRARLKT--------------------------------DDLMFLDFVKS
. . |.. . | .....|  . |....   ..  ..     ..  .. .||  ....                                .|  ..|..| 
NMIKLPWYNKFPKKWNWQ--TMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKK

LLQIDRTRRPSAKEALQHPWL
.||.| ..|..|..|||||..
MLQYDPDKRITAEQALQHPYF
Kinase 10580.AA DYRK2 205-527 35 1.6e-83 271.46 In-house 1-318 (318) Show / Hide 
Range on Protein: 205-527
Range on HMM: 1-318/318
Sequence Identity: 35% (116 aa)

YQIMEYLGSAAFSKAIQCQDKQTGQMLCMKIIENNKDYFDQSIDEIKLLKYINYNGDVDEKNVLKVYDYFYHKEHLFIVTELLKDNLYEFYKFNRENETQ
| | | .|.  |   . | |. |.|... |.| | | .  |   ||. |..|  .      |. .  ||||   |..|..|||  ||||. | |  .   
YEILEVIGKGSFGQVVKCYDHKTKQHVAIKMIRNKKRFHNQAYEEIRILHHIRRQDKDNTMNCVHMLDYFYFRNHHCITFELLSMNLYEYIKKNHFQG--

PYFTLGRLQKITQQILIGLDYIHSLRLIHCDLKPENILMKSYSKCQVKIIDFGSSCFIHD-HLSSYVQSRSYRAPEVILGCKYDYKIDMWSLGCILAELW
  |.|    . ...|| .|.  |  ..||||||||||| |.  .  .|.|||||||| |  ..  |.||| |||||||||.||.  |||||.|||.||| 
--FSLQLVRRFAHSILQCLRFLHKNNIIHCDLKPENILLKQWNRSGIKVIDFGSSCFEHQYRIYTYIQSRFYRAPEVILGGKYGMAIDMWSFGCIMAELY

TGNVLFQNDTVQGLLARVIGIIGPIPEWMFQEG-----RLVNNFFTNKRLLYQDVFEEGEPSQNINDTSDMPGRRQKSGKIQILVPKKSNLRARLK-TDD
||  ||  .  .  .|  . ..|  |. .|.       .  ..||. .       ||    . .  .. ..|. ...... .. .|  ... . || ..|
TGYPLFPGENENDQFACMMEVLGMPPKKFFDTWFYIHCFRRKYFFNSH------CFEWYC-TFMTDHSMEIPKHYKNRHG-KRRPPGSKSWKSVLKGCED

LMFLDFVKSLLQIDRTRRPSAKEALQHPWL
  |.||.|  .. | . | ....||.|||.
ENFIDFIKRCFEWDPSERMTPSQALKHPWI
Kinase 10580.AA S_TKc 205-527 25 2.6e-79 270.73 SMART 1-231 (231) Show / Hide 
Range on Protein: 205-527
Range on HMM: 1-231/231
Sequence Identity: 25% (84 aa)

YQIMEYLGSAAFSKAIQCQDKQTGQMLCMKIIENNKDYFDQSIDEIKLLKYINYNGDVDEKNVLKVYDYFYHKEHLFIVTELLKD---NLYEFYKFNREN
|.|.. .|. ||.|  .|..| ||.   .|||       .. . ||..||        . .|. | ||.|.. .||..|.|..     .|... | .. .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-------HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH

ETQPYFTLGRLQKITQQILIGLDYIHSLRLIHCDLKPENILMKSYSKCQVKIIDFGSSCFIHDHLSSYVQSRSYRAPEVILGCKYDY-KIDMWSLGCILA
 .. .|.  . .....||. .|.|.||.. ||.||||||||. .    ..||.|||.....    .... .. |.||||.   .|.. |.|.||.||||.
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

ELWTGNVLFQNDTVQGLLARVIGIIGPIPEWMFQEGRLVNNFFTNKRLLYQDVFEEGEPSQNINDTSDMPGRRQKSGKIQILVPKKSNLRARLKTDDLMF
|. .|  .|.    . .. ..||                                                                         .  .
EMLCGYPPFP---QMQMMFKKIG-------------------------------------------------------------------------SPEA

LDFVKSLLQIDRTRRPSAKEALQ-------HPWL
.||.. .|| | ..||.| ||||       |||.
KDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 10580.AA Pkinase 205-527 25 6.7e-64 223.39 Pfam 1-293 (293) Show / Hide 
Range on Protein: 205-527
Range on HMM: 1-293/293
Sequence Identity: 25% (88 aa)

YQIMEYLGSAAFSKAIQCQDKQTGQMLCMKIIENNKDYFDQSID-----EIKLLKYINYNGDVDEKNVLKVYDYFYHKEHLFIVTELLKDNLYEFYKFN-
|.| . .|| .|..  .|..| ||.. ..|||.  ..  .. .      ||...| .|       .|... ||.|. | |. .|.|..   ||       
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN------HPNIVRLYDWFEDKDHIYMVMEYCEGGLY-VMDLFD

---RENETQPYF--TLGRLQKITQQILIGLDYIHSLRLIHCDLKPENILMKSYSKCQV----KIIDFGSSC---FIHDHLSSYVQSRSYRAPEVIL-GCK
   .  . .  |  .   ....  ||| ||.|.|| . ||.||||||||..  .....    ||.|||...     ........ .. |.|||||. | .
YIST--WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID--NNGHIDACVKICDFGLAKQFDY-NNSMTTFCGTPWYMAPEVIRGGQY

YDYKIDMWSLGCILAELWTGNVLFQND----TVQGLLARVIGIIGPIPEWMFQEGRLVNNFFTNKRLLYQDVFEEGEPSQNINDTSDMPGRRQKSGKIQI
|..|.||||.||||.|. .|. .|...    .    ....  | ||.... ... . . .||  ..                                  
YGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H------------------------------

LVPKKSNLRARLKTDDLMFLDFVKSLLQIDRTRRPSAKEALQHPWL
       .. . .  .  ..||.|..|. | ..||.|...|||||.
-----F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 10580.AA DYRK1 205-444 35 2e-56 193.8 In-house 1-238 (321) Show / Hide 
Range on Protein: 205-444
Range on HMM: 1-238/321
Sequence Identity: 35% (86 aa)

YQIMEYLGSAAFSKAIQCQDKQTGQMLCMKIIENNKDYFDQSIDEIKLLKYINYNGDVDEKNVLKVYDYFYHKEHLFIVTELLKDNLYEFYKFNRENETQ
|.|   .|  .| . ..  |.|. ..  .||| | | ...|   ||.||  .| .   .. .....   | ...|| .|.|||  |||.  .    |   
YEIDSLIGKGSFGQVVKAYDHQEQEYVAIKIIKNKKPFYNQAQIEIRLLELMNKHDKEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLR----NTHF

PYFTLGRLQKITQQILIGLDYIHS--LRLIHCDLKPENILMKSYSKCQVKIIDFGSSCFIHDHLSSYVQSRSYRAPEVILGCKYDYKIDMWSLGCILAEL
    |   .|. ||..  | .. .  | .|||||||||||.    . ..|||||||||   . .  |.||| ||.|||.|| .|| .|||||||||| |.
RGVSLNLTRKFAQQMCTALLFMSTPELDIIHCDLKPENILLCNPKRSAIKIIDFGSSCQLGQRIYQYIQSRFYRSPEVLLGIEYDMAIDMWSLGCILVEM

WTGNVLFQNDTVQGLLARVIGIIGPIPEWMFQEGRLVNNFFT
 ||  ||     .  . ... ..|  |. | ...     .|.
HTGEPLFSGSNEVDQMNKIVEVLGMPPKHMIDQAPKAHKYFE
Kinase 10580.AA YAK 205-449 38 4.9e-56 188.71 In-house 1-243 (347) Show / Hide 
Range on Protein: 205-449
Range on HMM: 1-243/347
Sequence Identity: 38% (95 aa)

YQIMEYLGSAAFSKAIQCQDKQTGQMLCMKIIENNKDYFDQSIDEIKLLKYINYNGDVDEKN----VLKVYDYFYHKEHLFIVTELLKDNLYEFYKFNRE
| .   ||   |   . ||   |  ..  |.| |   || |.. ||..|.  |   | ..||    .|. ||.| || |. .| |.|  ||||. | |. 
YIVLDMLGQGTFGQVVKCQNCDTNELFAVKVIKNRQAYFQQAKNEIQILRVLNQQHDPNNKNYQKHILRMYDFFVHKNHFCLVFEMLSNNLYEYLKQNKF

NETQPYFTLGRLQKITQQILIGLDYIHSLRLIHCDLKPENILMKSYSKCQVKIIDFGSSCFIHDHLSSYVQSRSYRAPEVILGCKYDYKIDMWSLGCILA
      |     .  | ||| |.    . ..||||||||||. .   |  .|||||||||     .  |.|.| ||.||.|..  |   |||||||||.|
CG----FSFQLIRQWTKQILDGMCVLENKQIIHCDLKPENIMLCKPNKPEIKIIDFGSSCQEKKMVYTYIQQRHYRSPEIIVWMIYCTSIDMWSLGCIVA

ELWTGNVLFQNDTVQGLLARVIGIIGPIPEWMFQEGRLVNNFFTNKRLL
||  |  .|        . |.| . |  | ||   ||  | .|  ....
ELFLGLPIFPGNSEYNQIKRIIDMLGYPPSWMIDQGRFKNKYF--HCHD
Kinase 10580.AA HIPK 205-411 39 1.7e-53 166.56 In-house 1-205 (329) Show / Hide 
Range on Protein: 205-411
Range on HMM: 1-205/329
Sequence Identity: 39% (82 aa)

YQIMEYLGSAAFSKAIQCQDKQTGQMLCMKIIENNKDYFDQSIDEIKLLKYINYNGDVDEKNVLKVYDYFYHKEHLFIVTELLKDNLYEFYKFNRENETQ
| ..|.||   | . . |  . |. |  .||. |.  |  |   |...|. .  . . || .... |..| ||.| ..| |.|  |||.| |   .|.  
YEVLEFLGRGTFGQVVKCWKRGTNEMVAIKILKNHPYYARQGQIEVSILHCLS-QENADEYHFVRAYECFHHKNHTCLVFEMLEQNLYDFQK---QNKFM

PYFTLGRLQKITQQILIGLDYIHSLRLIHCDLKPENILMKSYSKC--QVKIIDFGS-SCFIHDHLSSYVQSRSYRAPEVILGCKYDYKIDMWSLGCILAE
|   |  .  |.||.|  |  . .| ||| |||||||..   ..|   ||.||||| | . .   . |.||| |||||.||| ..  ..|||||||..||
P-LPLKHIRPILQQVLTALMKLKELGLIHADLKPENIMLVDPTRCPYRVKVIDFGSASHVSKVVCNTYLQSRYYRAPEIILGLPFCENHDMWSLGCVIAE

LWTGNVLFQN
|  |  |. .
LFLGWPLYPG
Kinase 10580.AA CAMK 210-399 19 5.5e-39 122.78 In-house 1-324 (425) Show / Hide 
Range on Protein: 210-399
Range on HMM: 1-324/425
Sequence Identity: 19% (62 aa)

YLGSAAFSKAIQCQDKQTG------------QMLCMKIIENNK---------------------------DYFDQS--IDEIKLLKYINYNGD-VDEKNV
 ||. .|.|   |..|.|.            |   .|||. .|                           . .|.     ||...| .. .|  .| .|.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

LKVYDYFYH-------------------KEHLFIVT---ELLKDN-----LYEFYKFNRENETQ---------PYFTLGRLQKITQQILIGLDYIHSLRL
.| |...                     ..|...|.   |.         |... . .. .  .          .||    ... .||. ...|.||.  
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

IHCDLKPENILMKSYSK---------------CQVKIIDFGSSCFIHDH--------------------------LSSYVQSRSYRA-PEVILGCK----
.|.||||||||. . ..               ...|||||| .... .                           .. .. . .| | |||..|..    
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

----------YDYKIDMWSLGCIL
          |..|.||||.|.||
QNATDEEKPYYGPKCDMWSCGVIL
Kinase 10580.AA PRP4 316-453 40 2.9e-32 113.51 In-house 112-250 (320) Show / Hide 
Range on Protein: 316-453
Range on HMM: 112-250/320
Sequence Identity: 40% (57 aa)

TQQILIGLDYIHSLRLIHCDLKPENILMKSYSKCQVKIIDFGSSCFIHDH-LSSYVQSRSYRAPEVILGCKYDYKIDMWSLGCILAELWTGNVLFQNDTV
.||... |  .  .  .| |.|| |||  . ||   |..||||   ||.  .  | .|| |||||.|.| .||| ||||| || |.||.|| ..|   | 
AQQLFLALKHLKKCNILHADIKPDNILV-NESKNTLKMCDFGSASHIHENEITPYLVSRFYRAPEIIIGHPYDYQIDMWSVGCTLYELYTGKIMFPGKTN

QGLLARVIGIIGPIPEWMFQEGRLVNNFF-TNKRLLYQDV
   |  .  . | .|  | . | .. |.|  |  ..|| |
NHMLKLFMDYKGKMPNKMIRKGQFKDNHFDQNCNFMYQEV
Kinase 10580.AA CLK 205-345 31 2.6e-30 87.51 In-house 1-149 (350) Show / Hide 
Range on Protein: 205-345
Range on HMM: 1-149/350
Sequence Identity: 31% (47 aa)

YQIMEYLGSAAFSKAIQCQDKQTG-QMLCMKIIENNKDYFDQSIDEIK-LLKYINYNGDVDEKNV---LKVYDYFYH-KEHLFIVTELLKDNLYEFYKFN
| |.  ||. .|.|  .|.| . | .    |||.| . | ...  ||.  .| || ..| . |.    .| .|.| . . |  ||.||.  ..|.| | |
YEIVCTLGEGTFGKVVECWDHKNGKKYVALKIIRNVEKYREAAWVEINQIMKKINEKHDPNNKYWEHCWKMNDWFDYGHGHICIVFELYGLSIYDFMKSN

R---ENETQPYFTLGRLQKITQQILIGLDYIHSLRLIHCDLKPENILMKS
.    |. .||  .   .... |..  .   |...|.| |||||||.  .
NSKMPNKYIPY-PIDHIRHMAYQLCEAVKFLHDMKLTHTDLKPENICFVD
Kinase 10580.AA CLK 349-450 44 2.1e-27 78.62 In-house 184-292 (350) Show / Hide 
Range on Protein: 349-450
Range on HMM: 184-292/350
Sequence Identity: 44% (48 aa)

CQVKIIDFGSSC---FIHDHLSSYVQSRSYRAPEVILGCKYDYKIDMWSLGCILAELWTGNVLFQNDTVQGLLARVIGIIG-PIPEWMFQEGR---LVNN
. ...|||||     | | | |  |..| |||||||||. . .. | || |||| || ||  |||       ||    | | ||| || |  |       
THICVIDFGSATKIRFDHEHHSTIVSTRHYRAPEVILGLGWSQPCDVWSIGCILFELYTGFTLFQTHDNREHLAMMERIMGMPIPQWMIQRTRRFKVKQK

FFTNKRLLY
.| . ||..
YFYHNRLDW
Kinase 10580.AA CAMK 502-527 34 7.5e-12 33.75 In-house 400-425 (425) Show / Hide 
Range on Protein: 502-527
Range on HMM: 400-425/425
Sequence Identity: 34% (9 aa)

DFVKSLLQIDRTRRPSAKEALQHPWL
|.....|| | ..|......|.|||.
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 10580.AA PRP4 205-296 28 5.2e-10 32.9 In-house 1-95 (320) Show / Hide 
Range on Protein: 205-296
Range on HMM: 1-95/320
Sequence Identity: 28% (27 aa)

YQIMEYLGSAAFSKAIQCQDKQTGQ-MLCMKIIENNKDYFDQSIDEIKLLKYINYN--GDVDEKNVLKVYDYFYHKEHLFIVTELLKDNLYEFYK
|... | |.  ||  ..|.|.  |. |   ||| ||    .    |.  |. .| .     | . ... .. |.|. |. .| | .  || |  |
YRVYGYCGQGVFSNVCRCRDQTRGNEMVAIKIIRNNEIMHKTGLRELEILQKLNDAPTDKNDKFHCVRMFRHFNHRQHMCLVFECMSMNLREVLK
Kinase 10580.AA TyrKc 205-527 18 4.3e-09 -75.71 SMART 1-280 (280) Show / Hide 
Range on Protein: 205-527
Range on HMM: 1-280/280
Sequence Identity: 18% (65 aa)

YQIMEYLGSAAFSKAIQCQDKQTGQMLCMKIIENNKDYFDQSIDEIKLLKYI-NYNGDVDEKNVLKVYDYFYHK-------EHLFIVTELLKD-NLYEFY
 .  . ||. || .  ... |   ..   | . ...      ..|..... .   .     .|... | .  ..       | |.||.|. .  .| .. 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHH-----PNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

KFNRENETQPYFTLGRLQKITQQILIGLDYIHSLRLIHCDLKPENILMKSYSKCQVKIIDFGSSCFIHDH------LSSYVQSR--SYR--------APE
. .|..     ...  | ..  ||  | .|.|| ..|| ||   |.| .  .. .||| ||| | .|.|.       . |...   . .        |||
RKHRPK-----LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVG--ENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPE

VILGCKYDYKIDMWSLGCILAELWT-GNVLFQN-----DTVQGLLARVIGI-IGPIPEW---MFQEGRLVNNFFTNKRLLYQDVFEEGEPSQNINDTSDM
.|  .|.  | | || |  . |. | |     .      . | ....|      |.|.    |                                     
CINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS------------------------------------

PGRRQKSGKIQILVPKKSNLRARLKTDDLMFLDFVKSLLQIDRTRRPSAKEALQHPWL
                 .         | |.    |.  . |   ||. .|   |  .
-----------------F-----VCCPDEMYQ-IMKQCWHEDPEDRPTFSEI--HECF
Kinase 10580.AA CLK 500-527 35 1.3e-07 18.11 In-house 323-350 (350) Show / Hide 
Range on Protein: 500-527
Range on HMM: 323-350/350
Sequence Identity: 35% (10 aa)

FLDFVKSLLQIDRTRRPSAKEALQHPWL
. | .. .| .| ..|...|.|||||. 
LFDLIRKMLEYDPSKRITCKDALQHPFF
Kinase 10580.AA YAK 499-527 37 2.8e-05 13.46 In-house 319-347 (347) Show / Hide 
Range on Protein: 499-527
Range on HMM: 319-347/347
Sequence Identity: 37% (11 aa)

MFLDFVKSLLQIDRTRRPSAKEALQHPWL
.|.||.  ||| .   | ..  | ||| .
CFIDFINQLLQLNPRERWKPMQAMQHPFI
Kinase 10580.AA DYRK1 496-527 40 0.000477 9.55 In-house 290-321 (321) Show / Hide 
Range on Protein: 496-527
Range on HMM: 290-321/321
Sequence Identity: 40% (13 aa)

DDLMFLDFVKSLLQIDRTRRPSAKEALQHPWL
| | | | .| .|| |  .| .  .||||...
DYLKFKDLIKRMLQYDPKQRITPYYALQHSFF
Kinase 10580.AA PRP4 500-527 35 0.000985 9.64 In-house 293-320 (320) Show / Hide 
Range on Protein: 500-527
Range on HMM: 293-320/320
Sequence Identity: 35% (10 aa)

FLDFVKSLLQIDRTRRPSAKEALQHPWL
| |.   .|. |  .| .  |||.|| .
FKDLLDKCLMLDPKKRITCNEALKHPFI
Kinase 10580.AA HIPK 494-527 32 0.002551 5.76 In-house 296-329 (329) Show / Hide 
Range on Protein: 494-527
Range on HMM: 296-329/329
Sequence Identity: 32% (11 aa)

KTDDLMFLDFVKSLLQIDRTRRPSAKEALQHPWL
| |   | .  | .. .|  .| .  |||.||. 
KIDRREFVHVLKKMCTWDAHKRITPCEALNHPFV