Gene 25907 (Tetrahymena)

25907

Species: Tetrahymena
Alias: 618, TTHERM_00286770, PreTt25907, 25907, 3688.m00054, 26.m00259
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: CMGC
Family: CDK
Subfamily: CDC2

Sequence

Name Sequence Type Origin Length Description Download
25907.AA Protein None 307 None Fasta, JSON
25907.kin_dom Protein Kinase Domain None 293 None Fasta, JSON
25907.NA RNA None 924 None Fasta, JSON

Protein domain

Protein domains of 25907.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 25907.AA CDC2 11-303 50 2.7e-198 615.68 In-house 1-301 (301) Show / Hide 
Range on Protein: 11-303
Range on HMM: 1-301/301
Sequence Identity: 50% (153 aa)

YVQLEKLGEGTYGVVFKAQDMQTQQLVAIKQIRIDPNEDE-GVPSTTLREISILKKLK-HKNIVKLLDVYVFPEAQKVSLVFEYYPQDLRGYLKQLQQKN
| ..||.||||||||.|..||||.|.||.|.||.. .... |||||..||||.||.|| |.||||| ||..    .|. .||||. .||. |......||
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ---NKLYMVFEYLDMDLKKYMDMSIPKN

QKEIPLSFYQNQFRQIIEGVDYCHSQGILHRDLKPQNILVSSTGEIKIADFGLARAFNYPLKELT--KDIVTLWYRSTELLLGESQYDIAIDMWSVGCIL
 |..|........ ||..||..||...|.||||||||||....|.||||||||||||..|....|  ...||||||..|.|||...|....||||.|||.
-KHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIF

AEF---VTFKPLFMGDSQIDQLFKIFQFSGTPNGVIWPNVKKYIDFKQTFPKFLPSNTLRIDPR------FKEQIRNEGIELIESLLQIVPEKRLNSDEA
||.   ||.||||.|||.||||||||.. ||||  .||.|... |.|.|||.. |... .| |.      . .....|||.|....||. |.||....||
AEMFMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPDYKNTFPRWKPQDLSKICPNNQKKKNQ-SCLDPEGIDLLMQMLQYDPQKRISAKEA

LKAPFF
|. |.|
LQHPYF
Kinase 25907.AA CDK 11-303 42 1.6e-158 510.94 In-house 1-284 (284) Show / Hide 
Range on Protein: 11-303
Range on HMM: 1-284/284
Sequence Identity: 42% (139 aa)

YVQLEKLGEGTYGVVFKAQDMQTQ-----QLVAIKQIRIDPN----EDEGVPSTTLREISILKKLKHKNIVKLLDVYVFPE---------AQKVSLVFEY
| .|||.||||||||.||.|.||.     |.||.|.||.. .    |.||.|.|..||||.||.| |.|||||.||..  .           |...||||
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

YPQDLRGYLKQLQQKNQKEIPLSFYQNQFRQIIEGVDYCHSQGILHRDLKPQNILVSSTGE-----IKIADFGLARAFNY------PLKELTKDIVTLWY
 ..|| .|..               .. ..|...|..||||..|.||||||||||....||     .|||||||||||.       |....|. .|||||
MDHDLKKYMD--------------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWY

RSTELLLGESQYD--IAIDMWSVGCILAEFVT---FKPLFMGDSQIDQLFKIFQFSGTPNGVIWPNVKKYIDFKQTFPKFLPSNTLRIDPRFKEQIRNEG
|. |||||...|.   .|||||||||.||..|    ||||.||| ||||||||.. |||.  .||.|.|. |.                           
RAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY---------------------------

IELIESLLQIVPEKRLNSDEALKAPFF
 .|....|.  |.||.....||. |.|
-DLLNKMLCYDPKKRISAEQALQHPYF
Kinase 25907.AA CMGC 11-303 25 7.29999999999e-132 435.99 In-house 1-513 (513) Show / Hide 
Range on Protein: 11-303
Range on HMM: 1-513/513
Sequence Identity: 25% (132 aa)

YVQLEKLGEGTYGVVFKAQD--------------MQTQQLVAIKQIRIDPNEDEG---------VPSTTLREISILKKLK-----------------HKN
|  ..|.||||||||.|..|              ..|...|||| |. .. ..|.         .|...||||.|||.|.                 |.|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IVKLLDVYVFPE---------------AQKVSLVFEYYPQDLRGYLKQLQQK-----------------------NQKEIPLSFYQNQFRQIIEGVD--Y
||||.|......                ... ||||| ..|| .|.|. |..                       | | ...   .  ..||..|..  |
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKY

CHSQG--ILHRDLKPQNILVSST--------------------GEIKIADFGLARAFNYP---------------------LKELTKDIVTLWYRSTELL
|||..  |.||||||.|||....                    |..||.||||||... .                     .. .| ..||.|||. |.|
CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEIL

LGESQYD---------IAIDMWSVGCILAEFVT--------FKPLFMGDSQ-----------IDQLFKIFQFSGTPN---------------GVIWPNVK
|| ..|.          .|||||||||.|| .|         |||| |.|            ||||||||.  |||.                 .|||..
LGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMI

KYIDFKQ--------------T------------FPKFLPSNTLRIDPRFKE-------------------------------QIRNEGIELIESLLQIV
|. ....              .            ||.. | .  .. |....                               ..  ..|.|.. .||. 
KLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYD

PEKRLNSDEALKAPFF
|.||.  ..||. |.|
PDKRITAEQALQHPYF
Kinase 25907.AA CDK5 11-303 42 2.3e-120 382.2 In-house 1-287 (287) Show / Hide 
Range on Protein: 11-303
Range on HMM: 1-287/287
Sequence Identity: 42% (127 aa)

YVQLEKLGEGTYGVVFKAQDMQTQQLVAIKQIRIDPNEDEGVPSTTLREISILKKLKHKNIVKLLDVYVFPEAQKVSLVFEYYPQDLRGYLKQLQQKNQK
| ..||.||||||.|.||.. .|. .||.|..|.| .|||||||| .|||..|| ||||||| | || .  | .|  ||||.  |||. |. ...     
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLD-SEDEGVPSTAIREICLLKELKHKNIVRLHDV-IHSE-KKLTLVFEFCDQDLKKYMDSCNG----

EIPLSFYQNQFRQIIEGVDYCHSQGILHRDLKPQNILVSSTGEIKIADFGLARAFNYPLKELTKDIVTLWYRSTELLLGESQYDIAIDMWSVGCILAEFV
|. .   .    |   |. .||.. .||||||||| |..  || | |||||||||  | .  .  .||||||    |.|  .|   |||||.|||.|| .
EMDMHIIKSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVRCYSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAEMA

-TFKPLFMGDSQIDQLFKIFQFSGTPNGVIWPNVKKYIDFK---QTFPKFLPSNTLRIDPRFKEQIRNEGIELIESLLQIVPEKRLNSDEALKAPFF
 . .||| | .. |||..||.  |||.   || . |  |.|   | .|.. .  ..   .  ..    .| .| . .||. |..|.  ..||. |.|
NAGRPLFPGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQ--QIVPK-LDEKGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase 25907.AA PITSLRE 11-303 40 5.2e-99 335.23 In-house 1-295 (295) Show / Hide 
Range on Protein: 11-303
Range on HMM: 1-295/295
Sequence Identity: 40% (121 aa)

YVQLEKLGEGTYGVVFKAQDMQTQQLVAIKQIRID-PNEDEGVPSTTLREIS-ILKKLKHKNIVKLLDVYVFPEAQKVSLVFEYYPQDLRGYLKQLQQKN
.. | . .|||||||..|.| .|   ||.| . ..   | || | | ||||. ||. |.| |||... . .     |. .|.||   ||.. .   ...|
FQCLNRIHEGTYGVVYRAKDKRTDEIVALKRLKMERQKEKEGFPITSLREINMILMALQHPNIVNVKEIVMGSNMDKIYMVMEYVEHDLKSLMENMKRRN

QKEIPLSFYQNQFRQIIEGVDYCHSQGILHRDLKPQNILVSSTGEIKIADFGLARAFNYPLKELTKDIVTLWYRSTELLLGESQYDIAIDMWSVGCILAE
 ..  ..       |   ||.. |.  |.|||||  |.| |  |  ||.|||||| . .|.| .|. .||||||. |||||   |  ..||||||||.||
-QPFKPGEIKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLYSHKGILKICDFGLAREYGSPIKPYTPCVVTLWYRAPELLLGCKKYSTPVDMWSVGCIFAE

FVTFKPLFMGDSQIDQLFKIFQFSGTPNGVIWPNVKKYIDFKQTF-PKFLPSNTLRIDPRFK--EQIRNEGIELIESLLQIVPEKRLNSDEALKAPFF
|.| |||| |.| |||. .||.  |||.  ||| ...   .| .   .  | |.||   ||.  . |   | .|   .|   |..|.. ..||| |.|
FITMKPLFQGKSEIDQINCIFKEMGTPTEKIWPGWTELPHWKMMNNFPHYPYNNLRK--RFPAENHISDTGFDLLNQMLTYNPKNRITASDALKHPWF
Kinase 25907.AA S_TKc 11-303 31 9.6e-94 318.66 SMART 1-231 (231) Show / Hide 
Range on Protein: 11-303
Range on HMM: 1-231/231
Sequence Identity: 31% (96 aa)

YVQLEKLGEGTYGVVFKAQDMQTQQLVAIKQIRIDPNEDEGVPSTTLREISILKKLKHKNIVKLLDVYVFPEAQKVSLVFEYYPQ---DLRGYLKQLQQ-
|  |.|.|.|..|.|.|...  |...||||.|.           ...|||.|||| .|.|||||.||..    ... .|.|| ..   ||. |.|. .  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRH

KNQKEIPLSFYQNQFRQIIEGVDYCHSQGILHRDLKPQNILVSSTGEIKIADFGLARAFNYPLKELTKDIVTLWYRSTELLLGESQYDI-AIDMWSVGCI
.... .|    .  ..||.....||||.||.||||||.|||...  .|||.|||||| .       |  ..|.||.. |.|    .|.  ..|.||.|||
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCI

LAEFVTFKPLFMGDSQIDQLFKIFQFSGTPNGVIWPNVKKYIDFKQTFPKFLPSNTLRIDPRFKEQIRNEGIELIESLLQIVPEKRLNSDEALK------
|.|... .|.|    |....||.                                              |....|. .||  ||||.   |||.      
LYEMLCGYPPFP---QMQMMFKKIG------------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIK

-APFF
  |.|
CHPWF
Kinase 25907.AA PCTAIRE 11-303 41 2.4e-92 313.07 In-house 1-291 (291) Show / Hide 
Range on Protein: 11-303
Range on HMM: 1-291/291
Sequence Identity: 41% (125 aa)

YVQLEKLGEGTYGVVFKAQDMQTQQLVAIKQIRIDPNEDEGVPSTTLREISILKKLKHKNIVKLLDVYVFPEAQKVSLVFEYYPQDLRGYLKQLQQK-NQ
|..|.|||||||  |.| .   |  ||| | || .   .|| | |  ||.| || ||| ||| | |. .. . |   |||||  .||. |. .  .  | 
YIKLDKLGEGTYATVYKCRSKLTDNLVALKEIRLE--HEEGAPCTAIREVSLLKDLKHANIVTLHDI-IHTHHQ-LTLVFEYMDMDLKQYMDDCGNIMNM

KEIPLSFYQNQFRQIIEGVDYCHSQGILHRDLKPQNILVSSTGEIKIADFGLARAFNYPLKELTKDIVTLWYRSTELLLGESQYDIAIDMWSVGCILAEF
... |  .     |.  | .||| . |||||||||| |.   || | ||||||||   | |   ...||||||. . |.| ..|   |||| ||||..| 
HNVKLFLF-----QLLRGLAYCHRRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSHEVVTLWYRPPDVLMGSTDYSTQIDMWGVGCIFYEM

VTFKPLFMGDS------QIDQLFKIFQFSGTPNGVIWPNVKKYIDFKQ-TFPKFLPSNTLRIDPRFKEQIRNEGIELIESLLQIVPEKRLNSDEALKAPF
 | .||| |          |||  ||.. |||    || ||   .|..  ||....   .   ||.  .|  ....|...|||  ...|.  ..|.| |.
CTGRPLFPGSTDSHYPGVKDQLHMIFRILGTPDEKTWPGVKSNEEFRTYNFPRYREQPLINHAPRLD-KILKQCQDLLTMLLQYESKNRVSAEKAMKHPY

F
|
F
Kinase 25907.AA PFTAIRE 11-303 39 6.6e-86 291.7 In-house 1-287 (287) Show / Hide 
Range on Protein: 11-303
Range on HMM: 1-287/287
Sequence Identity: 39% (118 aa)

YVQLEKLGEGTYGVVFKAQDMQTQQLVAIKQIRIDPNEDEGVPSTTLREISILKKLKHKNIVKLLDVYVFPEAQKVSLVFEYYPQDLRGYLKQLQQK-NQ
|..|||||||.|  |.|.    .||.|| | ||.  ...||.| |  || | || ||| ||| | |.    |    ..||||   ||  |. .     . 
YEKLEKLGEGSYATVYKGISCINQQFVALKEIRL--QQEEGTPFTAIREASLLKNLKHANIVCLHDIIHTKET--LTFVFEYVHTDLCQYMDKHPGGMHP

KEIPLSFYQNQFRQIIEGVDYCHSQGILHRDLKPQNILVSSTGEIKIADFGLARAFNYPLKELTKDIVTLWYRSTELLLGESQYDIAIDMWSVGCILAEF
. . |  .     | . |  ||| . .||||||||| |.| .|| | ||||||||   | .   . .||||||    |||   |   .||| ||||. | 
NNVRLFLF-----QLLRGLSYCHQRRVLHRDLKPQNLLISHCGELKLADFGLARAKSVPSHTYSHEVVTLWYRPPDVLLGSTEYSTHLDMWGVGCIFVEM

VTFKPLFMGD-SQIDQLFKIFQFSGTPNGVIWPNVKKYIDFKQTFPK--FLPSNTLRIDPRFKEQIR--NEGIELIESLLQIVPEKRLNSDEALKAPFF
.. .|.| |     ||| |||.  |||.   || | .   .|    .  |  .  |.   .  ..|   ... .|.  .||. |..|.  .||.. |.|
MWGQPAFPGMKDITDQLEKIFKVLGTPTEDTWPGVCHLPNYKPHWFRGRFYKPKKLC---HQWPRIYYIPHAEDLMMKMLQCEPRDRVSAQEAMQHPYF
Kinase 25907.AA CDK4 11-303 39 1.9e-84 286.88 In-house 1-290 (290) Show / Hide 
Range on Protein: 11-303
Range on HMM: 1-290/290
Sequence Identity: 39% (119 aa)

YVQLEKLGEGTYGVVFKAQDMQTQQLVAIKQIRIDPNED-EGVPSTTLREISILKKLK---HKNIVKLLDVYVFPEAQK----VSLVFEYYPQDLRGYLK
|...  .||| || |..| |..| . || ||.||  .|.  |.|  |.||||....|.   | |||||.||  . .       . .|||   .||. || 
YQCVAEIGEGAYGTVYRARDLHTGHFVALKQVRIPIGEEGGGMPMSTIREISVMRHLCQFEHPNIVKLMDVCHVMDTDRAEMKITMVFEHCDWDLHTYLD

QLQQKNQKEIPLSFYQNQFRQIIEGVDYCHSQGILHRDLKPQNILVSSTGEIKIADFGLARAFNYPLKELTKDIVTLWYRSTELLLGESQYDIAIDMWSV
.. .     .|    .   .|.. |||. ||  | |||||||||||.| |..|.||||||| . .  . ||  .||||||. | ||  | |   .|||||
KCPP---PGMPPCTIKHMMHQLLRGVDFLHSHRIIHRDLKPQNILVTSDGHVKLADFGLARIYSFQMA-LTPVVVTLWYRAPEVLL-QSYYNTPVDMWSV

GCILAEFVTFKPLFMGDSQIDQLFKIFQFSGTPNGVIWP--NVKKYIDFKQTFPKFLPSNTLRIDPRFKEQIRNEGIELIESLLQIVPEKRLNSDEALKA
||| ||    .||| | |  ||| |||   |.| .  ||   .     |.|. |. . .        |  .. . |..|..  |   ..||.   ..|. 
GCIFAEMYCRRPLFCGQSEKDQLHKIFDVMGLPPEDDWPRDVSLPWDHFPQRHPRPFKD--------FCPHMCKQGDDLLQKMLCYNHHKRMSAYQCLQH

PFF
|.|
PYF
Kinase 25907.AA Pkinase 11-303 30 1.1e-83 289.14 Pfam 1-293 (293) Show / Hide 
Range on Protein: 11-303
Range on HMM: 1-293/293
Sequence Identity: 30% (96 aa)

YVQLEKLGEGTYGVVFKAQDMQTQQLVAIKQIRIDPNEDEGVPSTTLR--EISILKKLKHKNIVKLLDVYVFPEAQKVSLVFEYYPQ-----DLRGYLKQ
|. ..|.|.|..|.|.|...  |...||.|.|. . .|..... | .|  ||.|.|.|.|.|||.|.|..     ... .|.|| .      ||  |.. 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYIST

LQQKNQKEI--PLSFYQNQFRQIIEGVDYCHSQGILHRDLKPQNILVSSTGEI----KIADFGLARAF-NYPLKELTKDIVTLWYRSTELLLGESQYDIA
   .... .  .    .. ..||..|..||||.||.||||||.|||....|.|    ||.|||||. | . .   .|   .|.||.. |...| . |. .
---WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPK

IDMWSVGCILAEFVTFKPLFMGD----SQIDQLFKIFQFSGTPNGVIWPNVKKYIDFKQTFPKFLPSNTLRIDPRFKEQIRNEGIELIESLLQIVPEKRL
.||||.||||.|... .|.| |.    . .||...|..  |.|.   ||.     .|. ...   .     . ....  .  |....|...|.  |.||.
VDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H-----F-HWTFHNWSEECKDFIKWCLCKDPKKRP

NSDEALKAPFF
. ...|. |.|
TAEQILQHPWF
Kinase 25907.AA CRK7 11-303 35 6.9e-82 278.36 In-house 1-343 (343) Show / Hide 
Range on Protein: 11-303
Range on HMM: 1-343/343
Sequence Identity: 35% (122 aa)

YVQLEKLGEGTYGVVFKAQDMQTQQLVAIKQIRIDPNE---DEGVPSTTLREISILKKLKHKNIVKLLDVYVFP------EAQK--VSLVFEYYPQDLRG
|  ..  |||||| | ||.. .| ..|| | .| | ||    || | |  ||| ||. |.|.|||.| .. .          .|  . .||||   || |
YEMIMQIGEGTYGQVYKAKNKHTGEMVALKKVRMD-NEKIKKEGFPITAIREIKILRQLNHQNIVNLKEIVTDKQDASEFKKHKGSFYMVFEYMDHDLMG

YLKQLQQKNQKEIPLSFYQNQFRQIIEGVDYCHSQGILHRDLKPQNILVSSTGEIKIADFGLARAFNYPL--KELTKDIVTLWYRSTELLLGESQY----
    |. |  ... ..     ..|. ||.|||| ...||||.|  |||.   ||.||||||||| .|     . .|  ..|||||  |||||| .|    
L---LESKEMHHFSHQQCKCFMKQLLEGMDYCHKKNFLHRDIKCSNILMNNQGEVKIADFGLARLYNSEEKRRPYTNRVITLWYRPPELLLGEERYTEQH

----------------------------------DIAIDMWSVGCILAEFVTFKPLFMGDSQIDQLFKIFQFSGTPNGVIWPNVKKYIDFKQTFPKFLPS
                                    .|||||.||||.|  | ||.| |   ..|| ||..  |.||   ||.| |   ..   ||    
ILKELIRNIKSIQLSLLISIYLKLTVQSSIFKKSGPEIDMWSCGCILGELFTKKPIFQGNNEMAQLEKIYKICGSPNPNNWPEVMKLPWWNTMKPKRQYN

NTLRIDPRFKEQ---IRNEGIELIESLLQIVPEKRLNSDEALKAPFF
  || .   ...   .  |   |   .|   |.||    |.|  ..|
RRLREEFYHHKKPVFMPKECLDLLDKMLCLDPKKRFTAEECLQHDWF
Kinase 25907.AA CDK7 123-303 41 7.2e-70 185.1 In-house 110-288 (288) Show / Hide 
Range on Protein: 123-303
Range on HMM: 110-288/288
Sequence Identity: 41% (75 aa)

QIIEGVDYCHSQGILHRDLKPQNILVSSTGEIKIADFGLARAFNYPLKELTKDIVTLWYRSTELLLGESQYDIAIDMWSVGCILAEFVTFKPLFMGDSQI
..  |. |||   |||||||| | |... |..|||||||||..  | . .|  .|| |||. ||| |  .|  ..||||||||.||     | . ||| |
MTLQGLEYCHRNWILHRDLKPNNLLMNENGQLKIADFGLARFYGSPNRIYTHQVVTRWYRAPELLFGARHYGTGVDMWSVGCIFAELMLRVPYLPGDSDI

DQLFKIFQFSGTPNGVIWPNVKKYIDFKQTFPKFLPSNTLRIDPRFKEQIRNEGIELIESLLQIVPEKRLNSDEALKAPFF
||| .|||  |||.   |||. .  |. . | .| .      . .|     .. ..|.. ..   | ||.   ..|| |.|
DQLTRIFQTLGTPTEEEWPNMCCMMDYIK-FKDFPGYSRTPLRHIFT-AASDDLLDLMCGMWTMNPCKRWTCTQCLKMPYF
Kinase 25907.AA CDK7 11-97 36 4.6e-35 90.5 In-house 1-88 (288) Show / Hide 
Range on Protein: 11-97
Range on HMM: 1-88/288
Sequence Identity: 36% (33 aa)

YVQLEKLGEGTYGVVFKAQDMQTQQLVAIKQIR---IDPNEDEGVPSTTLREISILKKLKHKNIVKLLDVYVFPEAQKVSLVFEYYPQDL
|  ....|||....|.||.| || | |||| |.   .    . |.  | .||| ||. ..| |.. |.|  .|     ..|||.. . ||
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKIKKLGHRSEAKDGINRTAIREIKILQEMQHDNVIGLID--IFMHKSNIQLVFDFMDWDL
Kinase 25907.AA TyrKc 11-303 22 1.1e-13 -1.41 SMART 1-280 (280) Show / Hide 
Range on Protein: 11-303
Range on HMM: 1-280/280
Sequence Identity: 22% (74 aa)

YVQLEKLGEGTYGVVFKAQDMQTQQLVAIKQIRIDPNEDEGVPSTTLREISILKKL--KHKNIVKLLDVYVFP-----EAQKVSLVFEYYPQ-DLRGYLK
 . ..||||| .|.|.|..     . ||.| .. |           .||..|..||  .|.|||.|. | . .     ... . .|.|| |  ||. ||.
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

QLQQKNQKEIPLSFYQNQFRQIIEGVDYCHSQGILHRDLKPQNILVSSTGEIKIADFGLARAF-----------NYPLKE--LTKDIVTLWYRSTELLLG
  . |    ....   .   || .| .| ||... ||||   |.||.. . .||.||||.|.             |  ||   .|. . .   . | .  
KHRPK----LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-N

ESQYDIAIDMWSVGCILAEFVTF-KPLF-------MGDSQIDQLFKIFQFSGTPNGVIWPNVKKYIDFKQTFPKFLPSNTLRIDPRFKEQIRNEGIELIE
.. . .. | || |  . |  |. ..         | .... .. |       |  .  | .                        |      |  ....
YGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-P-MS-----------------------F-VCCPDEMYQIMK

SLLQIVPEKRLNSDEALKAPFF
.  .  ||.| .  |     .|
QCWHEDPEDRPTFSEI--HECF
Kinase 25907.AA Pkinase_Tyr 11-103 30 3.1e-12 42.04 Pfam 1-100 (270) Show / Hide 
Range on Protein: 11-103
Range on HMM: 1-100/270
Sequence Identity: 30% (33 aa)

YVQLEKLGEGTYGVVFKAQDM----QTQQLVAIKQIRIDPNEDEGVPSTT------LREISILKKL-KHKNIVKLLDVYVFPEAQK--VSLVFEYYPQ-D
 . ..||||| .|.|.|.       .|.. ||.| ..      ||  .        .||..|.|.| .|.|||.|. | . .. .   . .|.|| |  |
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLK------EGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCT-DQGEPNQIYIVMEYMPHGD

LRGYLKQ
|. ||..
LLDYLRK
Kinase 25907.AA Pkinase_Tyr 126-164 46 5.4e-08 27.69 Pfam 122-160 (270) Show / Hide 
Range on Protein: 126-164
Range on HMM: 122-160/270
Sequence Identity: 46% (18 aa)

EGVDYCHSQGILHRDLKPQNILVSSTGEIKIADFGLARA
.| .| .|... ||||   |.||.... .||.||||||.
KGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARD