Gene 22277 (Tetrahymena)

22277

Species: Tetrahymena
Alias: 18.m00303, 3701.m00063, 1134, TTHERM_00218500, 22277, PreTt22277
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Atypical
Family: HisK

Sequence

Name Sequence Type Origin Length Description Download
22277.AA Protein None 1331 None Fasta, JSON
22277.kin_dom Protein Kinase Domain None 110 None Fasta, JSON
22277.NA RNA None 3996 None Fasta, JSON

Protein domain

Protein domains of 22277.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
HisKA 22277.AA HisKA 421-486 23 1.7e-09 38.8 SMART 1-89 (89) Show / Hide 
Range on Protein: 421-486
Range on HMM: 1-89/89
Sequence Identity: 23% (21 aa)

FKDKVIDSITHNLKTPLNGILLSCQTLQM-----------NLKQSEN------------LEILEHIYQNSFILLNMINDILDYSRFLKD
 |.. . .. | |.|||..|.. ...||.           .|   ..             |.|| |.. .  ....|||.||.||    
AKRQFLANMSHELRTPLTAIRGYAELLQDWYYKQRYHHWTDLDPEQRLPMLRREFNCEYREYLETIQREADRMQRLINDLLDLSRIEAG
HisKA 22277.AA HisKA 421-486 30 1.7e-09 36.07 Pfam 1-69 (69) Show / Hide 
Range on Protein: 421-486
Range on HMM: 1-69/69
Sequence Identity: 30% (21 aa)

FKDKVIDSITHNLKTPLNGILLSCQTLQM-NLKQSEN--LEILEHIYQNSFILLNMINDILDYSRFLKD
 | . . .. | |.|||..|.. ...||.   . .|    |.|| |.. .  ....|||.||.||    
AKRQFLANMSHELRTPLTAIRGYAELLQDYTDLDPEQMRREYLETIQREAQRMQRLINDLLDFSRIEAG
Kinase 22277.AA HisK 532-641 26 3e-43 149.99 In-house 1-164 (164) Show / Hide 
Range on Protein: 532-641
Range on HMM: 1-164/164
Sequence Identity: 26% (43 aa)

TDKNRLIQVLLQFLTNSIKFTQKG------YVKLKVSKY---------------------------KNAFKFTIEDTGQGMSKQQIERLGNLFM------
.|.||. |.|. ...|..||||||      |.|.||...                           || ......||| ||...|.. . ..|       
SDPNRIKQILINLISNALKFTQKGGIPFQGYIKIKVEQINTQNNIKYNSIFIQKIQENMVQEQLQQKNLIQISVQDTGCGMPEEQQKKIFKMFGNIDDQH

--------QPHKSY-QHGVGLGFIMCKHLLDKMSSE------NNLTVVSEENKGTTVIFFIRSD
        . .|.. |||.||| ..|..|  ....|      ....|.||..||.| .|.|. .
QMIKKTFNHQNKKNNQHGCGLGLTICNNLAKGLGPEHNQNGNRGIQVQSEVGKGSTFSFYIYNN
Kinase 22277.AA HATPase_c 532-641 25 7e-24 85.34 Pfam 1-120 (120) Show / Hide 
Range on Protein: 532-641
Range on HMM: 1-120/120
Sequence Identity: 25% (31 aa)

TDKNRLIQVLLQFLTNSIKFTQK-GYVKLKVSKYKNAFKFTIEDTGQGMSK------QQIERLGNLFMQPHK---SYQHG--VGLGFIMCKHLLDKMSSE
.| .|| ||.. ...|.||.|.. | ....|.. ..   .|.||.| |...      ..|.|.   | . ..   .   |   |||. .|. .....  .
GDPDRLHQVVWNLVDNAIKHTPEGGHITVRVHRDDDHVRITVEDNGPGIPPEMHSIAEDIPRIFEPFYRTDPDSRRKYGGGLTGLGLYICRRIVEQHGGT

NNLTVVSEENKGTTVIFFIRSD
  ..| ||...|||..| .  .
--IWVESEPGGGTTFTFTLPLE
Kinase 22277.AA HATPase_c 532-642 21 3.4e-19 71.0 SMART 1-130 (130) Show / Hide 
Range on Protein: 532-642
Range on HMM: 1-130/130
Sequence Identity: 21% (31 aa)

TDKNRLIQVLLQFLTNSIKFTQK--------------GYVKLKVSKYKNAFKFTIEDTGQGMSK------QQIERLGNLFMQPHK-----------SYQH
.| .|| |||.  |.|.||.|..              | ....|.       .|.||.| |...      ..|.|.   | .  .           .   
GDPDRLRQVLWNLLDNAIKHTPEGHADPDLHDGKPGGGRITVRVH------RITVEDNGPGIPPEMHKSIEDIPRIFEPFYRTDDSPSRMCPDSRSRKYG

G--VGLGFIMCKHLLDKMSSENNLTVVSEENKGTTVIFFIRSDH
|   |||.  || . ...  .  ..|       ||..| ..  .
GGLTGLGLSICKRIVEQHGGT--IWVE------TTFTFTLPLER
REC 22277.AA REC 1210-1327 28 4.8e-34 120.33 SMART 1-150 (150) Show / Hide 
Range on Protein: 1210-1327
Range on HMM: 1-150/150
Sequence Identity: 28% (46 aa)

QKILIVDDN----PFNILCLQ------TLLKKFNFL-------KTYEAHDGK-------EAVEKVQKE-------------HFDLILMDVNMP-------
 .||||||.    | .   |.       ||.| ..           || ||.       ||.|..|..             ..|||.||..||       
MRILIVDDDPAMAPVIREMLRNYTVIQRLLEKEGYENKMWMVEVVDEA-DGETLMNEIWEALELLQEHRDKKEDATTDQSEPPDLIIMDIMMPGDPFEDG

VMDGLEATARIKEMLRNNIIEPTKIFIVTAFGDSLDKQKALKIGADAHICKPMTLATLYNEL
 |||.|.. ||.           .| ..||..|  |...||. |||. |.|| ..  |   .
GMDGIELCRRIR-----------PIIMLTAHDDEEDRVRALEAGADDYITKPFDPEELLARI
Response_reg 22277.AA Response_reg 1212-1328 40 2.2e-29 107.79 Pfam 1-115 (115) Show / Hide 
Range on Protein: 1212-1328
Range on HMM: 1-115/115
Sequence Identity: 40% (48 aa)

ILIVDDNPFNILCLQTLLK-KFNFLKTYEAHDGKEAVEKVQKEHFDLILMDVNMPVMDGLEATARI-KEML-RNNIIEPTKIFIVTAFGDSLDKQKALKI
.|||||.| .   |...|. |  . .. || ||.||.|..|..|.|||.||.||| |||||...|| ..    .     |.| ..||.||  |...||. 
VLIVDDHPLMREGLRQILEQKEGYEVVAEADDGEEALEWWQEHHPDLIIMDINMPGMDGLELCRRIRRQHPHPQ-----TPIIMCTAHGDEDDAVEALQA

GADAHICKPMTLATLYNELK
||. .| ||  .. |.....
GANDYITKPFDPDELHAAIR