Gene 4011 (Tetrahymena)

4011

Species: Tetrahymena
Alias: TTHERM_00825470, 4011, 3683.m00041, 643, PreTt04011, 142.m00108
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: AGC
Family: RSK
Subfamily: RSK-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
4011.AA Protein None 786 None Fasta, JSON
4011.NA RNA None 2361 None Fasta, JSON
4011.kin_dom Protein Kinase Domain None 259 None Fasta, JSON

Protein domain

Protein domains of 4011.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Ank 4011.AA Ank 70-102 39 4.5e-09 36.99 Pfam 1-33 (33) Show / Hide 
Range on Protein: 70-102
Range on HMM: 1-33/33
Sequence Identity: 39% (13 aa)

NQVTPLMIAAEQGSEEIVILLLKAGAEIDMQDE
.  |||..|.. |..|.| .||..||....|| 
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank 4011.AA Ank 103-136 23 3.1e-05 23.13 Pfam 1-33 (33) Show / Hide 
Range on Protein: 103-136
Range on HMM: 1-33/33
Sequence Identity: 23% (8 aa)

NGNTALHIACMLSKSAIIDIFLNRFKPDISIKNK
.|.|.||.||.     ..  .|.    |. ....
DGFTPLHLACRCGHTEVVKMLLQ-HGADVNAQDD
Ank 4011.AA Ank 37-69 27 0.000524 18.71 Pfam 1-33 (33) Show / Hide 
Range on Protein: 37-69
Range on HMM: 1-33/33
Sequence Identity: 27% (9 aa)

TGWAPIHFACLNCNIQLVNKLIVNEANINQETN
 |. | | ||.. ... |  |. . |..|  ..
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Kinase 4011.AA AGC 457-715 33 3.4e-179 468.13 In-house 1-395 (395) Show / Hide 
Range on Protein: 457-715
Range on HMM: 1-395/395
Sequence Identity: 33% (134 aa)

FIIHSMLGKGSFGDVYLVQKK------DNLQYYAMKVLQKSK---MMKSNVIKYALTE------------RNVLSLSN----------HPFIVK-LNYSF
| .. ..|||||| ||||.||      |. .|||||||.|..   ..| | .....||            ||.|.. |          |||||| | |||
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QTEEK--LFLILDFAA---------GG-DMGKLLQ---KVKVLSENDARIYLSE-------ILLSLEYLHK-KDIIFRD-LKPDNIVIDSEGHALLTDFG
|....  |.......          || ..   ||   | ....|. ||.|..|       |.| |||||. ..|| || |||.||..|..||  |||||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LSKEGVLDYTEG-------------------------------------------------AKSFCG--SIAYLAPEMLKRRGHGKAVDWY--LFGVVMY
|.|||. |.. |                                                 ...|||  .  |.|||.|    .|||.||.  ..|..||
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

EMLTGNPPYYANT----------KEDLFNNIQ------NAPLALP----------SYLSQEAKSLLTALLERNPEMRLGCGRND-----ANEIKNHPFF
||||| ||.|...          ....|..|.      | .. .|          ...|.|||.|.. ||...|| |||||.||     |.||||||.|
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase 4011.AA RSK-Unclassified 457-715 49 6.8e-170 538.31 In-house 1-283 (283) Show / Hide 
Range on Protein: 457-715
Range on HMM: 1-283/283
Sequence Identity: 49% (141 aa)

FIIHSMLGKGSFGDVYLVQKKDNLQYYAMKVLQKSKMMKSNVIKYALTERNVLSLSNHPFIVKLNYSFQTEEKLFLILDFAAGGDMGKLLQ--KVKVLSE
|| | ..|.|.|| ||||.|||  | ||||||.|.||.. | |||..||.|.....||||||.|..||||. .|.|....  |||... ||  | | ..|
FIKHRLIGQGDFGKVYLVRKKDTQQIYAMKVLHKHKMIRHNKIKYVMTEQNIMATTNHPFIVTLYHSFQTQDYLYLCMEYCMGGDFFRHLQTRKEKCFCE

NDARIYLSEILLSLEYLHKKDIIFRDLKPDNIVIDSEGHALLTDFGLSKEG--------------------VLDYTEGAKSFCGSIAYLAPEMLKRRGHG
.|.|.|.||. . ||||||.|.|.||||||||| . |||. ||||.||...                    ..|   ...||||. .||||||..| ||.
DDVRFYASEVTAALEYLHKRDFIYRDLKPDNIVLHQEGHVMLTDFDLSIQAKDSKKPVMKGSAQSTYVDTKICDHGFRTNSFCGTEEYLAPEMIRRCGHT

KAVDWYLFGVVMYEMLTGNPPYYANTKEDLFNNIQNAPLALP--SYLSQEAKSLLTALLERNPEMRLGCGRNDANEIKNHPFF
|||||.. |.|||||| | ||||.| |. .|.||  ... .|  ||.|.....|. .||.|||  ||||.. ||..|| ||||
KAVDWWTLGIVMYEMLFGCPPYYGNNKNETFYNIEKNHVKFPHDSYISNNCRDLIKKLLQRNPAKRLGCKMGDADDIKRHPFF
Kinase 4011.AA RSK 457-715 41 1.1e-154 520.13 In-house 1-271 (271) Show / Hide 
Range on Protein: 457-715
Range on HMM: 1-271/271
Sequence Identity: 41% (114 aa)

FIIHSMLGKGSFGDVYLVQKK---DNLQYYAMKVLQKSKMMKSNVIKYALTERNVLSLSNHPFIVKLNYSFQTEEKLFLILDFAAGGDMGKLLQKVKVLS
...|...|.|||..||...|.   |. |.||||...|..   .    .. .||..|. ..|||||||.|.||.|.|...|.||..|||... |.|.|..|
YELHECIGQGSFSKVYVCKKCQHKDTNQHYAMKIIKKATRDVKDR-VCWEEERIILRYGHHPFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRLLKQKMFS

ENDARIYLSEILLSLEYLHKKDIIFRDLKPDNIVIDSE----GHALLTDFGLSKEGVLDYTEGAKSFCGSIAYLAPEMLKRRGHGKAVDWYLFGVVMYEM
|.....|..||.|..||||...|..|||||.||..|.|    ||. ..|||..|. ..|.......||....|.|||.|||.||..|.||..|||.||||
EREVKFYMAEIALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKICDFGFAKQ-LRDENGMLMTFCYTANYMAPEVLKRQGHDQACDWWSFGVLMYEM

LTGNPPYYANTKEDLFNNIQNAPLAL-------PSYLSQEAKSLLTALLERNPEMRLGCGRNDANEIKNHPFF
|||..|..........|.||...|..       ....|.|||.||...|.|.|..|||.|.|....||.||.|
LTGCTPFQNKPRDTPMNIIQRIKLGMFSMTHGNWDFISDEAKDLLRMMLHRDPHNRLGAGPNGVEQIKQHPWF
Kinase 4011.AA Akt 457-715 49 6.2e-152 489.03 In-house 1-264 (264) Show / Hide 
Range on Protein: 457-715
Range on HMM: 1-264/264
Sequence Identity: 49% (130 aa)

FIIHSMLGKGSFGDVYLVQKKDNLQYY-AMKVLQKSKMMKSNVIKYALTERNVLSLSNHPFIVKLNYSFQTEEKLFLILDFAAGGDMGKLLQKVKVLSEN
| .  .||||||| |.||.|||. ..| |||||.|..  . | .....||||.|   ||||||.|.|||||..||....|.. ||.   .||. .. ||.
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSED

DARIYLSEILLSLEYLHKKDIIFRD-LKPDNIVIDSEGHALLTDFGLSKEGVLDYTEGAKSFCGSIAYLAPEMLKRRGHGKAVDWYL-FGVVMYEMLTGN
 || | .|| | .|.||.|.||.|| ||| ||..|..||  ||||||.||... ... .|.|||. .|||||.|.  ||.|||||.  .|.|||||..|.
RARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGR

PPYYANTKEDLFNNIQNAPLALP--SYLSQEAKSLLTALLERNPEMRLGCGRNDANEIKNHPFF
||.|.  .. .| .|.|.|.  |  ...|.|.|.|.. ||...|..||| | |||.|||.||.|
PPFYNQDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase 4011.AA RSK 460-715 46 2.7e-149 502.29 In-house 1-278 (278) Show / Hide 
Range on Protein: 460-715
Range on HMM: 1-278/278
Sequence Identity: 46% (129 aa)

HSMLGKGSFGDVYLVQKK---DNLQYYAMKVLQKSKMMKSNV-IKYALTERNVLSLSN-HPFIVKLNYSFQTEEKLFLILDFAAGGDMGKLLQKVKV---
...||.|..| |.|..|.   |. |.||||||.|.|...... .....||||.|.... |||||.|.|.||||.||.||...  ||.... ||| |    
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

LSENDARIYLSEILLSLEYLHKKDIIFRDLKPDNIVIDS---EGHALLTDFGLSKEGVLDYTEGAKSFCGSIAYLAPEMLK----RRGHGKAVDWYLFGV
.||..|..|..|| | .|.||...||.|||||.||. |.   |||  |||||..|....|... ...||..|.|.||||||    ..||.||.||. .||
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

VMYEMLTGNPPYYA---NTKEDLFNNIQNAP--LALP--SYLSQEAKSLLTALLERNPEMRLGCGRNDANEIKNHPFF
.|||||||.||...   |........||..   | .|  .|||||||.|....|.|.|..|||||..||.|||.||.|
LMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase 4011.AA SGK 457-715 43 9.69999999999e-145 450.18 In-house 1-283 (283) Show / Hide 
Range on Protein: 457-715
Range on HMM: 1-283/283
Sequence Identity: 43% (124 aa)

FIIHSMLGKGSFGDVYLVQKKDN------------------LQYYAMKVLQKSKMM-------KSNVIKYALTER-NVLSLSNHPFIVKLNYSFQTEEKL
|.. . .|||||| ||.|..||                    . ||||||||           | .  |. ..|| ..|.. .|||||.| |.|||..||
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

FLILDFAAGGDMGKLLQKVKVLSENDARIYLSEILLSLEYLHKKDIIFRDLKPDNIVIDSEGHALLTDFGLSKEGVLDYTEGAKSFCGSIAYLAPEMLKR
.. .|.. ||.|.  ||. | ..|  ||.| .|| . |||||..|||.|||||.||. |..||. ||||||.|||. . ... ..|||. .|||||.|. 
YFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKT-NDTTFTFCGTPEYLAPEVLRK

RGHGKAVDWYLFGVVMYEMLTGNPPYYANTKEDLFNNIQNAPLALPSYLSQEAKSLLTALLERNPEMRLGCGRNDANEIKNHPFF
..|...|||.. | |.|||..| ||.| . |. .. || | || .| . | .|..|.. ||...|. |||  ..|. ||||||||
QPHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLGT-KRDFMEIKNHPFF
Kinase 4011.AA AktR 457-715 48 1.8e-142 479.64 In-house 1-268 (268) Show / Hide 
Range on Protein: 457-715
Range on HMM: 1-268/268
Sequence Identity: 48% (131 aa)

FIIHSMLGKGSFGDVYLVQKK-DNLQYYAMKVLQKSKMMKSNVIKYALTERNVLS-LSNHPFIVKLNYSFQTEEKLFLILDFAAGGDMGKLLQKVKVLSE
| .. .|||| ||.||||||| || ..||||.. |.|. . | .....||||..  ..|||||||| |.|||.||||.|... .||..   |.| | .||
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

NDARIYLSEILLSLEYLHKK-DIIFRDLKPDNIVIDSEGHALLTDFGLSK-EGVLDYTEGAKSFCGSIAYLAPEMLKR-RGHGKAVDWYLFGVVMYEMLT
..||.| ..||| |||||.. .||.|||||.||..|..||  .||||||| ... .|.| |.||||. .|.||||...  ||.|.|||. ||.. |||.|
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVT

GNPPYYANTKEDLFNNIQNAP---LALPSYLSQEAKSLLT-ALLERNPEMRLGCGRNDANEIKNHPFF
|.|| |.. ....| .|.. .      |||.|...|.|..  || .||..||| ..|.. |||.||.|
GCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase 4011.AA p70 457-715 38 1.4e-101 343.8 In-house 1-299 (299) Show / Hide 
Range on Protein: 457-715
Range on HMM: 1-299/299
Sequence Identity: 38% (116 aa)

FIIHSMLGKGSFGDVYLVQKKD---NLQYYAMKVLQKSKMMKSNV-IKYAL-------------------------TERNVLSLSNHPFIVKLNYSFQTE
|     |||| .| |..| |     . ..||||||.| |   .      .                           |||.|.  .||||..| |.|||.
FELLKVLGKGGYGKVFQVRKVTGEDTGKIYAMKVLRKAKIVRNQKDTAHTREDEDKNDGNNNDNDDGLSKRLERTFAERNILEEVKHPFICDLHYAFQTN

EKLFLILDFAAGGDMGKLLQKVKVLSENDARIYLSEILLSLEYLHKKDIIFRDLKPDNIVIDSEGHALLTDFGLSKEGVLDYTEGAK------------S
.||.|||..  ||    .| .  .. |. |. ||||| ..||.||...||.|||||.|.  .. ||  ||||||.|| .    .||.            .
GKLYLILEYLHGGELFMHLERHGIWMEDTACFYLSEIICALEHLHQHGIIYRDLKPENCMLNQQGHVVLTDFGLCKESI---HDGAVDEEDPENVNATHT

FCGSIAYLAPEMLKRRGHGKAVDWYLFGVVMYEMLTGNPPYYANTKEDLFNNIQNAP--LALPSYLSQEAKSLLTALLERNPEMRLGCGRNDANEIKNHP
||| | | |||.| | ||..||||.  |. || |||| ||. . .. .  . |. .   |.|| ||..|.. |. .|| |.|  |.| | .|| .|. ||
FCGTIEYMAPEILMRCGHNHAVDWWSLGCLMYDMLTGGPPFTGENRKKTIDKILKGKQGLKLPPYLTHEMRDLIKKLLKRHPTQRWGAGPEDAADIQEHP

FF
||
FF
Kinase 4011.AA PKA 457-715 38 3.5e-100 339.11 In-house 1-263 (263) Show / Hide 
Range on Protein: 457-715
Range on HMM: 1-263/263
Sequence Identity: 38% (104 aa)

FIIHSMLGKGSFGDVYLVQKKDNLQYYAMKVLQKSKMMKSNVIKYALTERNVLSLSNHPFIV-KLNYSFQTEEKLFLILDFAAGGDMGKLLQKVKVLSEN
| |   ||.|||| |.|...|.. .|||||.| |..  . . .   ..|.|.|.. .||||| |. ..||.. .|........||.| . |.|.. .|. 
FEIIQTLGTGSFGRVMLCRHKHSGNYYAMKMLKKQEIVRLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYLRKSGRFSNP

DARIYLS-EILLSLEYLHKKDIIFRDLKPDNIVIDSEGHALLTDFGLSKEGVLDYTEGAKSFCGSIAYLAPEMLKRR-GHGKAVDWYLFGVVMYEMLTGN
.|..|   .| | |||||...|| ||||| || ||..||  .|||| .|. .   |   .. ||   |||||..... ||||.|||  .|.. ||||.| 
HAKFYAASQIVLALEYLHSQNIIYRDLKPENILIDKNGHIKITDFGFAKKVDD-RT---WTLCGTPEYLAPEIIQSKNGHGKSVDWWALGILIYEMLAGY

PPYYAN--TKEDLFNNIQNAPLALPSYLSQEA---KSLLTALLERNPEMRLGCGRNDANEIKNHPFF
|| |..  .. .... |.|. .  |..... |   |.|.  ||..... |.|. .|..| ||||..|
PPFYDHNRDPMQIYEKICNGKIKFPRHFDSDANYFKDLIKKLLQVDLTKRYGNMKNGVNDIKNHKWF
Kinase 4011.AA PKC 457-715 40 8.6e-100 324.16 In-house 1-262 (262) Show / Hide 
Range on Protein: 457-715
Range on HMM: 1-262/262
Sequence Identity: 40% (106 aa)

FIIHSMLGKGSFGDVYLVQKKDNLQYYAMKVLQKSKMMKSNVIKYALTERNVLSL-SNHPFIVKLNYSFQTEEKLFLILDFAAGGDMGKLLQKVKVLSEN
|  . .||||||| | |. .|.. .|||.||| |   ..   .  ..||. ||.| ..||| ..|  .|||...|| .. .  |||     |... ..| 
FNFLKVLGKGSFGKVMLAERKGTDEYYAIKVLKKDVIIQDDDVECTMTEKRVLALAWKHPFLTHLHCCFQTMDRLFFVMEYVNGGDLMFHIQQQRRFKEE

DARIYLSEILLSLEYLHKKDIIFRDLKPDNIVIDSEGHALLTDFGLSKEGVLDYTEGAKSFCGSIAYLAPEMLKRRGHGKAVDWYLFGVVMYEMLTGNPP
 || |  ||.. | .||.|.|| |||| ||. .|.|||  ..|||..||....  . ...|||   |.||| |.    ||.|||  ||| ||||. | .|
HARFYAAEIICALQFLHEKGIIYRDLKLDNVLLDHEGHIKIADFGMCKENMWNG-DTTSTFCGTPDYIAPEILQYQEYGKSVDWWAFGVLMYEMMAGQSP

YYANTKEDLFNNIQNAPLALPSYLSQEAKSLLTALLERNPEMRLGCGRND---ANEIKNHPFF
  . . ..||..| .     | .||.||.|........|||.||||.. .   ...|. ||||
FHGEDEDELFQSIMHDNPHYPRWLSKEAVSICKGFMTKNPEKRLGCHPQQEEGEQDIREHPFF
Kinase 4011.AA S_TKc 457-715 32 5.8e-91 309.41 SMART 1-231 (231) Show / Hide 
Range on Protein: 457-715
Range on HMM: 1-231/231
Sequence Identity: 32% (87 aa)

FIIHSMLGKGSFGDVYLVQKKDNLQYYAMKVLQKSKMMKSNVIKYALTERNVLSLSNHPFIVKLNYSFQTEEKLFLILDFAAG--GDMGKLLQKVKV---
. |.  .|||.|| ||....|.  ...|.|..           . .. |...|.  .||.|||| ..||. ..|....... |  ||. ....| .    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---LSENDARIYLSEILLSLEYLHKKDIIFRDLKPDNIVIDSEGHALLTDFGLSKEGVLDYTEGAKSFCGSIAYLAPEMLKRRGHGK-AVDWYLFGVVMY
   ..| .|| |. .|.. |||.|.. || |||||.|| .|.  |  ..||||...         ..|||.  |.|||.|   |.|| ..||. .|...|
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

EMLTGNPPYYANTKEDLFNNIQNAPLALPSYLSQEAKSLLTALLERNPEMRLGCGRNDANE--IKNHPFF
|||.| ||..  . . .|..|           |.|||...  .|...|| |...    ..|  ||.||.|
EMLCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 4011.AA Pkinase 457-715 26 6.8e-77 266.57 Pfam 1-293 (293) Show / Hide 
Range on Protein: 457-715
Range on HMM: 1-293/293
Sequence Identity: 26% (81 aa)

FIIHSMLGKGSFGDVYLVQKKDNLQYYAMKVLQKSKMMKSNVIKYAL-TERNVLSLSNHPFIVKLNYSFQTEEKLFLILDFAAGG----DMGKLLQ--KV
. |.. .|.|||| ||. ..|.. . .|.|.. |..  ..  .  .. .|  ..   |||.||.| ..|... .. ...... ||    |   ...  . 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

KVL--SENDARIYLSEILLSLEYLHKKDIIFRDLKPDNIVIDSEGHA----LLTDFGLSKEG-VLDYTEGAKSFCGSIAYLAPEMLK-RRGHGKAVDWYL
...  ||.... |. .||  |||.|.. || |||||.|| ||..||      ..||||.|      ..  ...|||.. |.||| .. ....|..||.. 
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS--MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

FGVVMYEMLTGNPPYYAN------TKEDLFNNIQNAPLALPSYLS---------------------QEAKSLLTALLERNPEMRLGCGRNDANEIKNHPF
.|...||||.|.||..        ..  ....|  .||  ... .                     .|.|.... .|...|. |..     | .|..||.
CGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT-----AEQILQHPW

F
|
F
Kinase 4011.AA TyrKc 457-715 22 1.1e-14 14.68 SMART 1-280 (280) Show / Hide 
Range on Protein: 457-715
Range on HMM: 1-280/280
Sequence Identity: 22% (66 aa)

FIIHSMLGKGSFGDVYLVQKKDNLQYYAMKVLQKSKMMKSNVIKYALTERNVLSLS--NHPFIVKLNYSFQTE-------EKLFLILDFAAGGDMGKLLQ
     .|| | || ||. . |   .  | |.|....      ..  . | ....    .|| ||.|     ..       | |.... ....||  . |.
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

KVKV-LSENDARIYLSEILLSLEYLHKKDIIFRDLKPDNIVIDSEGHALLTDFGLSKEGVLD--------YTEG----AKSFCGSIAYLAPEMLKRRGHG
| .  |.  |   .   |    ||||.| .| |||   |. .......  .|||||...  |        |        . .   |  .||| .. .   
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

KAVDWYLFGVVMYEMLT-GNPPYYA-----NTKEDLFNNIQNA-PLALPSY--------LSQEAKSLLTALLERNPEMRLGCGRNDANEIKNHPFF
 . | . |||.|.|..| | .||.       . .........   .  | .         ..|  .. .   ...||.|        .||  | .|
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRP-----TFSEI--HECF
Kinase 4011.AA Pkinase_Tyr 642-670 34 0.008537 10.09 Pfam 200-231 (270) Show / Hide 
Range on Protein: 642-670
Range on HMM: 200-231/270
Sequence Identity: 34% (11 aa)

FGVVMYEMLT-GNPP-YYANTKEDLFNNI-QN
|||.|.|..| |  | |.  . |.... | ..
FGVLMWEIFTYGEQPTYPGMSNEEVYEYIYED
Kinase 4011.AA Pkinase_Tyr 457-473 41 0.059268 7.24 Pfam 1-17 (270) Show / Hide 
Range on Protein: 457-473
Range on HMM: 1-17/270
Sequence Identity: 41% (7 aa)

FIIHSMLGKGSFGDVYL
 ..  .||.|.||.||.
ITFGKKLGEGAFGEVYK